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Chemoembolization

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https://www.readbyqxmd.com/read/29342456/correlation-between-resection-margin-and-disease-recurrence-with-a-restricted-cubic-spline-model-in-patients-with-resected-hepatocellular-carcinoma
#1
Woohyung Lee, Ho-Seong Han, Soyeon Ahn, Yoo-Seok Yoon, Jai Young Cho, YoungRok Choi
BACKGROUND: The relationship between resection margin (RM) and recurrence of resected hepatocellular carcinoma (HCC) is unclear. METHODS: We reviewed clinical data for 419 patients with HCC. The oncologic outcomes were compared between 2 groups of patients classified according to the inflexion point of the restricted cubic spline plot. RESULTS: The patients were divided according to an RM of <1 cm (n = 233; narrow RM group) or ≥1 cm (n = 186; wide RM group)...
January 17, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29335858/effects-of-aidi-injection-with-western-medical-therapies-on-quality-of-life-for-patients-with-primary-liver-cancer-a-systematic-review-and-meta-analysis
#2
Li Liu, Jian Liang, Xin Deng
OBJECTIVE: To evaluate the effects of Aidi Injection (, AD) in combination with Western medical therapies (WMT) in patients with primary liver cancer (PLC). METHODS: Randomized controlled trials (RCTs) comparing AD plus WMT with WMT alone were retrieved from inception to March 2013 by retrieving the literature database thoroughly and systematically. The extracted data from included studies were analyzed and synthesized by Review Manager 5.2 software. The Cochrane risk of bias tool was used to assess the quality of included studies, and Begg's and Egger's tests were used to evaluate the potential presence of publication bias...
January 15, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29335649/hyaluronic-acid-based-nano-sized-drug-carrier-containing-gellan-gum-microspheres-as-potential-multifunctional-embolic-agent
#3
Ming Fang Hsu, Yen Sheng Tyan, Yu Chen Chien, Ming Wei Lee
The purpose of this study was to develop a gellan gum-based multifunctional embolic agent. Calibrated spherical gellan gum and nanoparticle-containing gellan gum microspheres were prepared via water-in oil emulsification method. Self-assembled nanoparticles composed of short-chain hyaluronic acid and polyethylenimine as the doxorubicin carrier were prepared. The short-chain hyaluronic acid/polyethylenimine/ doxorubicin (sHH/PH/Dox) with the mean size was 140 ± 8 nm. To examine sHH/PH/Dox nanoparticle uptake into cells, the results confirmed that sHH/PH nanoparticles as drug carrier can facilitate the transport of doxorubicin into HepG2 liver cancer cells...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334777/endovascular-implantation-of-125i-seed-combined-with-transcatheter-arterial-chemoembolization-for-unresectable-hepatocellular-carcinoma
#4
Houbin Sun, Minghui Zhang, Ruibao Liu, Yan Liu, Yingwen Hou, Changjun Wu
AIM: The purpose of this study was to evaluate the efficacy and safety of the endovascular implantation of 125I seed under ultrasound and x-ray guidance combined with transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT). PATIENTS & METHODS: The study included 134 pathologically proven or clinically confirmed primary HCC patients with PVTT in our hospital from January 2013 to June 2015...
January 16, 2018: Future Oncology
https://www.readbyqxmd.com/read/29333117/baseline-tumor-lipiodol-uptake-after-transarterial-chemoembolization-for-hepatocellular-carcinoma-identification-of-a-threshold-value-predicting-tumor-recurrence
#5
Yusuke Matsui, Masahiro Horikawa, Younes Jahangiri Noudeh, John A Kaufman, Kenneth J Kolbeck, Khashayar Farsad
Background: The aim of the study was to evaluate the association between baseline Lipiodol uptake in hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE) with early tumor recurrence, and to identify a threshold baseline uptake value predicting tumor response. Patients and methods: A single-institution retrospective database of HCC treated with Lipiodol-TACE was reviewed. Forty-six tumors in 30 patients treated with a Lipiodol-chemotherapy emulsion and no additional particle embolization were included...
December 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/29325292/-therapeutic-effect-of-transcatheter-arterial-chemoembolization-combined-with-ultrasound-guided-microwave-ablation-for-treatment-of-liver-cancer-in-special-sites
#6
A Liu, W Xu, H Xu, Y Wang, Y M Gu
Objective: To investigate the efficacy and clinical value of transcatheter arterial chemoembolization (TACE) combined with ultrasound-guided microwave ablation for the treatment of liver cancer in special sites. Methods: The patients with liver cancer in special sites (the liver cancer was adjacent to the gallbladder, dome of diaphragm, gastrointestinal tract, heart, great vessels, and portal vein, with the shortest distance from the tumor to the organ/lumen < 0.5 cm ) were enrolled as treatment group, and the patients with primary liver cancer in normal sites treated in our hospital during the same period were randomly enrolled as control group...
December 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29317950/a-biliobronchial-fistula-in-a-patient-with-hepatocellcular-carcinoma-treated-with-chemoembolization-diagnosed-by-hepatobiliary-iminodiacetic-acid-scan-and-managed-by-endoscopic-retrograde-cholangiopancreatography
#7
Yousef Nassar, Sven Hida, Seth Richter
A biliobronchial fistula is an abnormal communication between the biliary tract and the bronchial tree. It may be a rare complication after treatment of hepatocellular carcinoma with transcatheter arterial chemoembolization (TACE). We present a case of a 71-year-old man that developed a biliobronchial fistula as a complication of hepatocellular carcinoma treated with TACE. It was successfully diagnosed by hepatobiliary iminodiacetic acid (HIDA) scan and treated with endoscopic retrograde pancreatography.
December 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/29317375/does-doxorubicin-survive-thermal-ablation-results-of-an-ex-vivo-bench-top-study
#8
Joseph D Morrison, Collin K Schlager, Amanda E Lee, Richard B van Breemen, Ron C Gaba
PURPOSE: We aimed to test the hypothesis that doxorubicin (DOX) survives thermal ablative heating in an ex vivo model of combined transarterial chemoembolization (TACE) and thermal ablation. METHODS: Fresh porcine psoas major muscle (3 samples, 15×10×3 cm) was submerged in aqueous DOX solution (60 µg/mL, 0.1 M) for 24 hours to passively saturate tissue. DOX-infused tissue was then dried and treated with microwave ablation (MWA) using a 2.45 GHz antenna at 65 W for 2, 5, and 10 minutes...
January 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29314222/impact-of-clinically-evident-portal-hypertension-on-clinical-outcome-of-patients-with-hepatocellular-carcinoma-treated-by-transarterial-chemoembolization
#9
Nam Hee Kim, Taeheon Lee, Yong Kyun Cho, Byung Ik Kim, Hong Joo Kim
BACKGROUND AND AIM: To determine the impact of clinically evident portal hypertension (CEPH) on prognosis of hepatocellular carcinoma (HCC) patients with Child-Pugh A cirrhosis who underwent transarterial chemoembolization (TACE). METHODS: A retrospective data analysis was performed for a total of 388 treatment-naïve HCC patients with Child-Pugh A cirrhosis who underwent TACE as first-line treatment from January 2000 to June 2014. Cumulative occurrence rate of complete response (CR), progression free survival (PFS), and overall survival (OS) were compared between patients with CEPH and those without CEPH [esophageal/gastric varices or low platelet count (<100,000/mm3 ) associated with splenomegaly]...
January 3, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29311396/prognostic-ability-of-bclc-b-subclassification-in-patients-with-hepatocellular-carcinoma-undergoing-transarterial-chemoembolization
#10
Marco Biolato, Giulia Gallusi, Massimo Iavarone, Giuseppe Cabibbo, Simona Racco, Adriano De Santis, Cristina Della Corte, Marcello Maida, Adolfo Francesco Attili, Angelo Sangiovanni, Calogero Cammà, Giuseppe La Torre, Antonio Gasbarrini, Antonio Grieco
Prognostic ability of BCLC-B Subclassification in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization Background and aims. A subclassification system for intermediate hepatocellular carcinoma (HCC) was recently proposed to optimize treatment allocation. The aim of this study was to assess the prognostic ability of that substaging proposal. PATIENTS AND METHODS: This is a retrospective multicenter cohort study including patients with intermediate HCC treated with transarterial chemoembolization (TACE)...
December 27, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29311028/duodenal-invasion-of-hepatocellular-carcinoma-following-transarterial-chemoembolization
#11
I-Chang Lin, Chi-Ming Tai, Chao-Ming Tseng
No abstract text is available yet for this article.
December 30, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29305738/efficacy-of-125i-versus-non-125i-combined-with-transcatheter-arterial-chemoembolization-for-the-treatment-of-unresectable-hepatocellular-carcinoma-with-obstructive-jaundice
#12
REVIEW
Shuangxi Li, Xuewen He, Lei Dang, Fangyu Xu, Jin Fang, Fenqiang Li, Wenhui Wang
PURPOSE: To compare the therapeutic effects of 125I versus non-125I combined with transcatheter arterial chemoembolization (TACE) for the treatment of unresectable hepatocellular carcinoma (HCC) with obstructive jaundice. METHODS: A retrospective analysis was conducted using the records of 54 consecutive patients who were initially diagnosed with HCC with obstructive jaundice between May 2009 and July 2016. Twenty-one cases (group A) were treated with percutaneous transhepatic biliary drainage (PTBD) followed by 125I radioactive seed strip implantation through the PTBD tube...
January 5, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29300089/monodisperse-micro-shell-structured-gelatin-microparticles-for-temporary-chemoembolization
#13
Bohyun Kim, Sang Woo Han, Song-Ee Choi, DaBin Yim, Jong-Ho Kim, Hans M Wyss, Jin Woong Kim
Embolization is a nonsurgical, minimally invasive procedure that deliberately blocks a blood vessel. Although several embolic particles have been commercialized, their much wider applications have been hampered owing mainly to particle size variation and uncontrollable degradation kinetics. Herein we introduce a microfluidic approach to fabricate highly monodisperse gelatin microparticles (GMPs) with a micro-shell structure. For this purpose, we fabricate uniform gelatin emulsion precursors using a microfluidic technique and consecutively crosslink them by inbound diffusion of glutaraldehyde from the oil continuous phase to the suspending gelatin precursor droplets...
January 4, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29299366/bridging-therapy-effectiveness-in-the-treatment-of-hepatocellular-carcinoma-prior-to-orthotopic-liver-transplantation
#14
Maria M Rubinstein, Andreas Kaubisch, Milan Kinkhabwala, John Reinus, Qiang Liu, Jennifer W Chuy
Background: Orthotopic liver transplantation (OLT) is the most effective treatment for hepatocellular carcinoma (HCC) in patients with underlying cirrhosis and portal hypertension. Availability of OLT is limited by donor-organ shortages, which increase patient waiting time until OLT. A variety of bridging therapies (BT) have been used to halt tumor progression in patients on the OLT waiting list. Despite complete radiologic responses following BT, viable tumor is often present in explants...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29291026/can-kushen-injection-combined-with-tace-improve-therapeutic-efficacy-and-safety-in-patients-with-advanced-hcc-a-systematic-review-and-network-meta-analysis
#15
Yingshi Zhang, Fuhai Hui, Yue Yang, Haixiao Chu, Xiaochun Qin, Mingyi Zhao, Qingchun Zhao
Objective: To assess the comparative efficacy and safety of combination treatment with Compound Kushen Injection (CKI) and transarterial chemoembolization (TACE) in patients with advanced hepatocellular carcinoma (HCC) through a systematic review and network meta-analysis and to identify the best conditions for using CKI. Materials and Methods: We performed a network meta-analysis based on randomized controlled trials. We searched databases for studies published by August 2017...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29289495/mechanism-of-action-pharmacokinetics-efficacy-and-safety-of-transarterial-therapies-using-ethiodized-oil-preclinical-review-in-liver-cancer-models
#16
Ron C Gaba, Regina M Schwind, Sebastien Ballet
PURPOSE: To systematically review mechanism of action, pharmacokinetics (PKs), efficacy, and safety of ethiodized oil-based locoregional therapy (LRT) for liver cancer in preclinical models. MATERIALS AND METHODS: A MEDLINE search was performed from 1988 to 2016. Search terms included hepatocellular carcinoma (HCC), HCC, liver-cell carcinoma, liver, hepatic, hepatocarcinoma, transarterial or chemoembolization, TACE, animal, Lipiodol, Ethiodol, iodized oil, and/or poppy-seed oil...
December 28, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29285389/early-sorafenib-induction-after-transarterial-chemoembolization-for-unresectable-hepatocellular-carcinoma-can-sorafenib-after-tace-improve-loco-regional-control
#17
Tsutomu Tamai, Kotaro Kumagai, Haruka Sakae, Hiroka Onishi, Kazuaki Tabu, Eriko Tabu, Kaori Muromachi, Akiko Saishoji, Kohei Oda, Seiichi Mawatari, Akihiro Moriuchi, Kazuhiro Sakurai, Akio Ido
This prospective study aimed to estimate the efficacy of sorafenib therapy after transarterial chemoembolization (TACE) for unresectable hepatocellular carcinoma (HCC). Between July 2011 and March 2013, 17 patients were enrolled, 11 of whom received sorafenib therapy. Patients who previously received TACE for HCC and whose disease progressed within a six-month period were given 400-800 mg sorafenib orally, once or twice daily, within the 3 weeks after a second TACE (sorafenib after TACE group). The response to treatment, time to progression (TTP), overall survival (OS), and adverse events (AEs) were recorded...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29282010/survival-benefit-of-hepatic-resection-versus-transarterial-chemoembolization-for-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus-a-systematic-review-and-meta-analysis
#18
Xiu-Ping Zhang, Kang Wang, Nan Li, Cheng-Qian Zhong, Xu-Biao Wei, Yu-Qiang Cheng, Yu-Zhen Gao, Han Wang, Shu-Qun Cheng
BACKGROUND: No consensus treatment has been reached for hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). Hepatic resection (HR) and transarterial chemoembolization (TACE) have been recommended as effective options, but which is better remains unclear. This meta-analysis is to compare the effectiveness of HR and TACE for HCC with PVTT patients. METHODS: The PubMed, EMBASE, Cochrane Library, VIP, Wan Fang, and Sino Med databases were systematically searched for comparing HR and TACE treating PVTT...
December 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29278654/up-to-seven-criteria-as-a-useful-predictor-for-tumor-downstaging-to-within-milan-criteria-and-child-pugh-grade-deterioration-after-the-initial-conventional-tace
#19
Yutaka Yasui, Kaoru Tsuchiya, Masayuki Kurosaki, Takaya Takeguchi, Yuko Takeguchi, Mao Okada, Wan Wang, Yohei Kubota, Tomoyuki Goto, Yasuyuki Komiyama, Mayu Higuchi, Kenta Takaura, Tsuguru Hayashi, Hitomi Takada, Nobuharu Tamaki, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Yasuhiro Asahina, Nobuyuki Enomoto, Yoshiro Himeno, Namiki Izumi
AIMS: Intermediate-stage hepatocellular carcinoma varies widely in tumor burden and liver function. This study aimed to clarify the importance of subclassification by the up-to-seven criteria in both clinical course and liver function deterioration in such patients. METHODS: We retrospectively analyzed 224 patients with Child-Pugh grade A who underwent initial transarterial chemoembolization for hepatocellular carcinoma. Tumor downstaging to within Milan criteria within 1 year and liver function worsening as Child-Pugh grade deterioration from A to B were analyzed...
December 26, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29277779/angiographic-evaluation-of-vascular-damage-in-rat-liver-after-administration-of-epirubicin-or-miriplatin
#20
Shuichi Kishimoto, Hiroki Aoki, Ryosuke Suzuki, Mai Inoue, Shoji Fukushima
BACKGROUND: Maintaining the function of blood vessels is important for the control of hepatocellular carcinoma (HCC) during treatment with repeated transcatheter arterial chemoembolization (TACE). This study was designed to compare the vascular damage caused by miriplatin (MPT), which has been commonly used for TACE, with the damage caused by epirubicin (EPI). MATERIALS AND METHODS: We used the portal vein of healthy rats for the administration of the drug (MPT or EPI) and/or soybean oil as vehicle...
January 2018: Anticancer Research
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