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https://www.readbyqxmd.com/read/29145036/liver-immunotolerance-and-hepatocellular-carcinoma-patho-physiological-mechanisms-and-therapeutic-perspectives
#1
REVIEW
Gaël S Roth, Thomas Decaens
At the moment of the diagnosis of hepatocellular carcinoma (HCC), 70% of patients have only access to palliative treatments, with very few therapeutic options. Liver immunology is very specific, and liver immunotolerance is particularly developed because of the constant and massive influx of antigens. Deregulation of hepatic immunotolerance is implicated in chronic liver diseases development and particularly in liver carcinogenesis. For these reasons, HCC may be an excellent candidate for anticancer immunotherapies such as immune checkpoint inhibitors targeting CTLA-4 and PD-L1/PD-1...
November 13, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29137099/chemoembolization-for-hepatocellular-carcinoma-fed-by-right-internal-thoracic-artery
#2
Tao Shen, Zhongzhi Jia, Yuanquan Huang, Shaoqin Li, Guomin Jiang, Lihua Cheng
The purpose of the study was to evaluate the value of transarterial chemoembolization (TACE) via right internal thoracic artery (RITA) for patients with unresectable hepatocellular carcinoma (HCC).From January 2000 to June 2016, a retrospective study was conducted of all patients with unresectable HCC who underwent TACE via RITA across 3 medical centers. The technical success, serum alpha-fetoprotein (AFP) level changes, major complications, disease control rate, and survival were evaluated and analyzed.During the study peroid, in all, 21 patients (men 21; mean age 57...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29137051/neutrophil-to-lymphocyte-and-aspartate-to-alanine-aminotransferase-ratios-predict-hepatocellular-carcinoma-prognosis-after-transarterial-embolization
#3
Chang Liu, Bang-Sheng Jia, Bing-Wen Zou, Hua Du, Lu-Nan Yan, Jia-Yin Yang, Li Jiang, Tian-Fu Wen, Wu-Sheng Lu
The neutrophil-to-lymphocyte ratio (NLR) reflects the systematic inflammatory status, and the aspartate aminotransferase-to-alanine aminotransferase ratio (AAR) is a biomarker of liver fibrosis and cirrhosis. These values can be conveniently obtained from routine blood tests; however, their combined clinical utility has not been extensively studied in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE). This study aimed to investigate the prognostic value of NLR-AAR in patients with unresectable HCC undergoing TACE...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29133753/transcatheter-arterial-chemoembolization-combined-with-simultaneous-computed-tomography-guided-radiofrequency-ablation-for-large-hepatocellular-carcinomas
#4
Tai-Yang Zuo, Feng-Yong Liu, Mao-Qiang Wang, Xian-Xian Chen
BACKGROUND: Currently, the treatment of large hepatocellular carcinoma (HCC) is still a challenging problem. Transcatheter arterial chemoembolization (TACE) is the main treatment for intermediate end-stage HCC, while it is only a palliative and not a curative treatment due to the existence of residual tumors, and radiofrequency ablation (RFA) has limitations in complete ablation of large HCC. We hypothesized that TACE combined with simultaneous RFA (herein referred to as TACE + RFA) could improve the efficacy and survival of large HCC...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29133751/shanghai-score-a-prognostic-and-adjuvant-treatment-evaluating-system-constructed-for-chinese-patients-with-hepatocellular-carcinoma-after-curative-resection
#5
Hui-Chuan Sun, Lu Xie, Xin-Rong Yang, Wei Li, Jian Yu, Xiao-Dong Zhu, Yong Xia, Ti Zhang, Yang Xu, Bo Hu, Li-Ping Du, Ling-Yao Zeng, Jian Ouyang, Wei Zhang, Tian-Qiang Song, Qiang Li, Ying-Hong Shi, Jian Zhou, Shuang-Jian Qiu, Qian Liu, Yi-Xue Li, Zhao-You Tang, Yu Shyr, Feng Shen, Jia Fan
BACKGROUND: For Chinese patients with hepatocellular carcinoma (HCC), surgical resection is the most important treatment to achieve long-term survival for patients with an early-stage tumor, and yet the prognosis after surgery is diverse. We aimed to construct a scoring system (Shanghai Score) for individualized prognosis estimation and adjuvant treatment evaluation. METHODS: A multivariate Cox proportional hazards model was constructed based on 4166 HCC patients undergoing resection during 2001-2008 at Zhongshan Hospital...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29124894/combined-transcatheter-arterial-chemoembolization-and-radiofrequency-ablation-in-single-session-for-solitary-hepatocellular-carcinoma-larger-than-7%C3%A2-cm
#6
Jie-Yu Yan, Jin-Long Zhang, Mao-Qiang Wang, Kai Yuan, Yan-Hua Bai, Yan Wang, Hai-Nan Xin, Zhi-Jun Wang, Feng-Yong Liu, Feng Duan, Jin-Xin Fu
AIMS: To evaluate technical feasibility and treatment results of combined transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) in single-session for solitary hepatocellular carcinoma (HCC) larger than 7 cm in diameter. METHODS: Institutional review board approved this retrospective study. Written informed consent was obtained from all patients. Between June 2007 and July 2013, 87 patients (75 men, 12 women; mean age, 55.5 years ± 15...
November 10, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29116741/high-performance-plga-magnetic-microspheres-prepared-by-rotating-membrane-emulsification-for-transcatheter-arterial-embolization-and-magnetic-ablation-in-vx2-liver-tumors
#7
Yi-Jun Liang, Hui Yu, Guodong Feng, Linlin Zhuang, Wei Xi, Ming Ma, Jun Chen, Ning Gu, Yu Zhang
Interventional embolization is a popular minimally invasive vascular therapeutic technique and has been widely applied for hepatocellular carcinoma (HCC) therapy. However, harmful effects caused by transcatheter arterial chemoembolization (TACE) and radioembolization, such as the toxicity of chemotherapy or excessive radiation damage, are serious disadvantages and significantly reduce the therapeutic efficacy. Here, a synergistic therapeutic strategy combined transcatheter arterial embolization and magnetic ablation (TAEMA) by using PLGA-magnetic microspheres (MMs) has been successfully applied to orthotopic VX2 liver tumors of rabbits...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29113660/functional-hepatic-imaging-as-a-biomarker-of-primary-and-secondary-tumor-response-to-loco-regional-therapies
#8
REVIEW
H L Lewis, M A Ghasabeh, P Khoshpouri, I R Kamel, T M Pawlik
Objective criteria to measure tumor response are a key tenet for assessment of treatment efficacy when evaluating a therapeutic modality. Several response criteria have been proposed including the Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST (mRECIST), RECIST 1-1, and European Association for the Study of the Liver (EASL) guidelines. Response following loco-regional therapies (LRT) can be particularly difficult to assess as post-treatment changes may not always relate to changes in lesion size...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113030/recent-advances-in-transarterial-embolotherapies-in-the-treatment-of-hepatocellular-carcinoma
#9
Edward Wolfgang Lee, Sarah Khan
Management of hepatocellular carcinoma (HCC) can be maximized with the utilization of multiple treatment modalities including transplant, surgical resection and locoregional therapies including ablative therapies and transarterial embolotherapies. Although transplant and surgical resection offer the best clinical outcomes, a limited number of patients are amenable to these surgical treatment options due to the advanced disease at presentation. Transarterial embolotherapies including conventional transarterial chemoembolization (cTACE), bland transarterial embolization (TAE), drug-eluting beads transarterial chemoembolization (DEB-TACE) and selective internal radiation therapy (SIRT) with Yttrium 90 (90Y) have played an increasingly important role for these patients with unresectable HCC...
November 8, 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29110700/transcatheter-arterial-chemoembolization-plus-sorafenib-versus-transcatheter-arterial-chemoembolization-alone-to-treat-advanced-hepatocellular-carcinoma-a-meta-analysis
#10
Rong Cai, Rongfeng Song, Pengfei Pang, Yan Yan, Yifeng Liao, Cuiling Zhou, Shuncong Wang, Xiuling Zhou, Huaping Wang, Hongyu Zhang, Huanhuan Sun, Haiqing Ma
BACKGROUND: Many studies have combined sorafenib with transcatheter arterial chemoembolization (TACE) to treat patients with advanced hepatocellular carcinoma (HCC), but the results are disputable. Thus, we conducted this meta-analysis to assess the efficacy and safety of the combination treatment in patients with advanced HCC. METHODS: Clinical data were collected from a computer search of literature published from January 2009 to June 2016 in PubMed, Web of Science, the Cochrane Library, China National Knowledge Infrastructure (CNKI), Wan Fang and the China Science and Technology Journal Database (CSTJ)...
November 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29110217/aggressive-intrahepatic-therapies-for-synchronous-hepatocellular-carcinoma-with-pulmonary-metastasis
#11
Z Hu, P Huang, Z Zhou, W Li, J Xu, K Xu, J Wang, H Zhang
PURPOSE: Prognosis of synchronous hepatocellular carcinoma (HCC) patients with pulmonary metastasis (PM) was poor, while aggressive intrahepatic therapies remained controversial. This study aimed to investigate the significance of aggressive intrahepatic therapies for synchronous PM-HCC. METHODS: Synchronous PM-HCC patients were retrospectively enrolled from Sun Yat-sen Memorial Hospital of Sun Yat-sen University during January 2000 and December 2015. Univariate and multivariate analysis were performed to investigate the prognostic factors...
November 6, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29108656/hepatocellular-carcinoma-treatment-ablation-and-arterial-embolization
#12
J I Bilbao, M Páramo, J M Madrid, A Benito
Percutaneous and endovascular techniques take an important role in the therapeutic management of patients with hepatocarcinoma. Different techniques of percutaneous ablation, especially indicated in tumors up to 2cm diameter offer, at least, similar results to surgical resection. Taking advantage of double hepatic vascularization and exclusive tumor nutrition by the artery, several endovascular techniques of treating the tumor have been developed. Intra-arterial administration of embolizing particles, alone or charged with drug (chemoembolization), will produce ischemia and consequent necrosis with excellent results in selected patients...
November 3, 2017: Radiología
https://www.readbyqxmd.com/read/29108428/the-effect-of-transarterial-chemoembolization-in-combination-with-kang-ai-injection-on-patients-with-intermediate-stage-hepatocellular-carcinoma-a-prospective-study
#13
Yue-Meng Wan, Yu-Hua Li, Zhi-Yuan Xu, Hua-Mei Wu, Ying Xu, Mei Yang, Xi-Nan Wu
BACKGROUND: The outcome of patients with intermediate stage hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (TACE) remains poor. Search for a more effective therapy is still necessary. OBJECTIVE: This study aimed to investigate the effect of combining TACE with Kang'ai (KA) injection for treating patients with intermediate stage HCC. METHODS: A total of 89 patients with intermediate stage HCC were enrolled and divided into TACE +KA group (n = 48) receiving repeated TACE plus KA injection, and TACE group (n = 41) receiving repeated TACE alone...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29108379/postoperative-adjuvant-radiotherapy-is-associated-with-improved-survival-in-hepatocellular-carcinoma-with-microvascular-invasion
#14
Liming Wang, Weihu Wang, Xuesong Yao, Weiqi Rong, Fan Wu, Bo Chen, Mei Liu, Shengtao Lin, Yunhe Liu, Jianxiong Wu
Purpose: Limited studies have compared the efficacy of postoperative adjuvant therapies in HCC patients with microvascular invasion (MVI). In this study we assess the efficacy of postoperative adjuvant conservative therapy (CT), trans-catheter arterial chemoembolization (TACE) and radiotherapy (RT) in HCC patients with MVI. Results: Kaplan-Meier survival analysis revealed that patients in the RT group have significantly improved RFS (RT vs TACE: p = 0.011; RT vs CT: p < 0...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108363/the-degree-of-hepatic-arterial-blood-supply-of-portal-vein-tumor-thrombus-in-patients-with-hepatocellular-carcinoma-and-its-impact-on-overall-survival-after-transarterial-chemoembolization
#15
Juxian Sun, Jie Shi, Bin Huang, Fantian Cheng, Weixing Guo, Wan Yee Lau, Shuqun Cheng
Purpose: To investigate the degree of arterial blood supply of portal vein tumor thrombus (PVTT) in patients with hepatocellular carcinoma (HCC), and to evaluate its impact on overall survival after transarterial chemoembolization using lipiodol +/- gelatin sponge particles (TACE). Results: Of the 10 patients who underwent surgery, the number of patients with good/mild/poor staining of PVTT by methylene blue were 3, 4, and 3, respectively. The degrees of methylene blue staining in these patients correlated well with the degrees of accumulation of lipiodol in PVTT in these patients, i...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108296/comparison-of-two-transarterial-chemoembolization-regimens-in-patients-with-unresectable-hepatocellular-carcinoma-raltitrexed-plus-oxaliplatin-versus-5-fluorouracil-plus-oxaliplatin
#16
Wei Cui, Wenzhe Fan, Qun Zhang, Jia Wen, Yonghui Huang, Jianyong Yang, Jiaping Li, Yu Wang
Aims: To compare the safety and efficacy of TACE using raltitrexed, oxaliplatin and epirubicin with 5-fluorouracil, oxaliplatin and epirubicin for patients with unresectable hepatocelluar carcinoma. Results: Median overall survival (OS) was 7.4 months in the raltitrexed group [95% confidence interval (CI): 5.4, 9.4) and 5.8 months in the control group (95% CI: 5.2, 6.4; P = 0.177). The median progression-free survival (PFS) time was significantly higher in the raltitrexed group (3...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108283/combination-of-sorafenib-and-tace-inhibits-portal-vein-invasion-for-intermediate-stage-hcc-a-single-center-retrospective-controlled-study
#17
Qi Yao, Hongsen Zhang, Bin Xiong, Chuansheng Zheng
Purpose: This study aims to investigate the effect of sorafenib plus Transarterial Chemoembolization (TACE) treatment on inhibiting portal vein invasion in patients with intermediate stage HCC. Materials and Methods: The consecutive medical records of patients with HCC were retrospectively analyzed from October 2009 to February 2015. The propensity score matching method was applied into group matching. The Kaplan-Meier method and the Log-Rank Test was used to estimate the median survival time, median time to progression and median time to portal vein invasion...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108202/-clinical-effect-of-ultraselective-transcatheter-arterial-chemoembolization-in-treatment-of-hepatocellular-carcinoma-originating-from-the-caudate-lobe-an-analysis-of-13-cases
#18
H J Yuan, F Y Liu, X Li, Y Guan, T Y Zuo, M Q Wang
Objective: To investigate the clinical effect of ultraselective transcatheter arterial chemoembolization (TACE) in the treatment of hepatocellular carcinoma (HCC) originating from the caudate lobe. Methods: A retrospective analysis was performed for 13 patients with solitary HCC originating from the caudate lobe who were admitted to Department of Interventional Radiology in PLA General Hospital from March 2013 to December 2016. A 2.6-F microcatheter was used to perform ultraselective TACE, and the embolization material was ultra-liquefied iodinated oil...
October 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29104490/transarterial-chemoembolization-a-favorable-postoperative-management-to-improve-prognosis-of-hepatitis-b-virus-associated-intrahepatic-cholangiocarcinoma-after-surgical-resection
#19
Seogsong Jeong, Bo Zheng, Jian Wang, Jiachang Chi, Ying Tong, Lei Xia, Ning Xu, Jianjun Zhang, Xiaoni Kong, Jinyang Gu, Qiang Xia
Background: There is no information regarding transarterial chemoembolization (TACE) as a postoperative management after hepatic resection for patients with hepatitis B virus (HBV)-associated intrahepatic cholangiocarcinoma (ICC). Methods: Forty-two patients with pathological confirmation of HBV-associated ICC were enrolled. Prognostic impact of the clinicopathological factors as well as postoperative TACE were evaluated. Computed tomography findings of HBV-associated ICC were assessed. Results: Tumor size of larger than 5 cm (hazard ratio [HR], 5...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29098752/hemobilia-immediately-after-transcatheter-arterial-chemoembolization-using-drug-eluting-beads-for-hepatocellular-carcinoma-with-intrahepatic-bile-duct-invasion
#20
Maiko Nishi, Issei Saeki, Takahiro Yamasaki, Masaki Maeda, Takuro Hisanaga, Takuya Iwamoto, Toshihiko Matsumoto, Isao Hidaka, Tsuyoshi Ishikawa, Taro Takami, Isao Sakaida
Transcatheter arterial chemoembolization (TACE) is used as a palliative treatment for unresectable hepatocellular carcinoma (HCC) worldwide. Recently, a novel drug delivery-embolic agent, the drug-eluting bead (DEB), was introduced for TACE. There are a few reports of tumor hemorrhage after TACE using DEB (DEB-TACE) for HCC. However, there have not been any reports of hemobilia immediately after DEB-TACE for an HCC with intrahepatic bile duct invasion. Here, the first such case is reported. A 71-year-old woman was admitted to our hospital to undergo DEB-TACE for multiple HCCs with worsening left intrahepatic bile duct dilatation...
November 2, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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