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https://www.readbyqxmd.com/read/28550167/prediction-of-response-to-sorafenib-in-hepatocellular-carcinoma-a-marker-panel-by-multiple-reaction-monitoring-mass-spectrometry
#1
Hyunsoo Kim, Su Jong Yu, Injun Yeo, Young Youn Cho, Dong Hyeon Lee, Yuri Cho, Eun Ju Cho, Jeong-Hoon Lee, Yoon Jun Kim, Sungyoung Lee, Jongsoo Jun, Taesung Park, Jung-Hwan Yoon, Youngsoo Kim
Sorafenib is the only standard treatment for unresectable hepatocellular carcinoma (HCC), but it provides modest survival benefits over placebo, necessitating predictive biomarkers of the response to sorafenib. Serum samples were obtained from 115 consecutive patients with HCC before sorafenib treatment and analyzed by multiple reaction monitoring-mass spectrometry (MRM-MS) and ELISA to quantify candidate biomarkers. We verified a triple-marker panel to be predictive of the response to sorafenib by MRM-MS, comprising CD5 antigen-like (CD5L), immunoglobulin J (IGJ), and galectin-3-binding protein (LGALS3BP), in HCC patients...
May 26, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28548587/comparison-of-efficacy-between-tace-combined-with-apatinib-and-tace-alone-in-the-treatment-of-intermediate-and-advanced-hepatocellular-carcinoma-a-single-center-randomized-controlled-trial
#2
Wei Lu, Xin-Li Jin, Chao Yang, Peng Du, Fu-Qiang Jiang, Jun-Peng Ma, Jian Yang, Peng Xie, Zhe Zhang
OBJECTIVE: This study was designed to compare the clinical efficacy and safety of transcatheter arterial chemoembolization (TACE) combined with apatinib and TACE alone in the treatment of intermediate and advanced hepatocellular carcinoma (HCC). METHODS: From March 2015 to August 2015, a total of 44 patients with moderate and advanced HCC, who were admitted in the Navy General Hospital of China, were included into this study. These patients were randomly divided into two groups: group A and group B...
May 26, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28547649/hklc-triages-more-hepatocellular-carcinoma-patients-to-curative-therapies-compared-to-bclc-and-is-associated-with-better-survival
#3
Michael C Wallace, Yi Huang, David B Preen, George Garas, Leon A Adams, Gerry MacQuillan, Jonathan Tibballs, John Ferguson, Shaun Samuelson, Gary P Jeffrey
BACKGROUND AND AIMS: The Hong Kong Liver Cancer (HKLC) system proposes to triage hepatocellular carcinoma (HCC) patients to more aggressive treatment and may be associated with superior survival compared with the Barcelona Clinic Liver Cancer (BCLC) system. We aimed to identify the influence of adherence to HKLC or BCLC treatment recommendations on survival and time to progression. METHODS: We examined a prospectively enrolled cohort of 292 patients undergoing 532 treatment episodes from a single clinical center...
May 25, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28547124/erratum-to-unresectable-hepatocellular-carcinoma-radioembolization-versus-chemoembolization-a-systematic-review-and-meta-analysis
#4
Laila Lobo, Danny Yakoub, Omar Picado, Caroline Ripat, Fiorella Pendola, Rishika Sharma, Rana ElTawil, Deukwoo Kwon, Shree Venkat, Loraine Portelance, Raphael Yechieli
No abstract text is available yet for this article.
May 25, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28542038/hypoxia-as-a-target-for-drug-combination-therapy-of-liver-cancer
#5
Cressida Bowyer, Andrew L Lewis, Andrew W Lloyd, Gary J Phillips, Wendy M Macfarlane
Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer deaths worldwide. The standard of care for intermediate HCC is transarterial chemoembolization, which combines tumour embolization with locoregional delivery of the chemotherapeutic doxorubicin. Embolization therapies induce hypoxia, leading to the escape and proliferation of hypoxia-adapted cancer cells. The transcription factor that orchestrates responses to hypoxia is hypoxia-inducible factor 1 (HIF-1). The aim of this work is to show that targeting HIF-1 with combined drug therapy presents an opportunity for improving outcomes for HCC treatment...
May 24, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28540985/predictors-of-micrometastases-in-patients-with-barcelona-clinic-liver-cancer-classification-b-hepatocellular-carcinoma
#6
Suk Won Suh, Yoo Shin Choi
PURPOSE: Transarterial chemoembolization (TACE) is indicated for Barcelona Clinic Liver Cancer (BCLC) B hepatocellular carcinoma (HCC). Whether TACE provides any long-term survival benefits remains unclear. We aimed to investigate micrometastases predictors with which to identify patients who would benefit from surgical resection (SR). MATERIALS AND METHODS: First, we analyzed risk factors of micrometastases, microvascular invasion, and poor histologic grade in 38 patients with newly diagnosed resectable BCLC stage B HCC limited to one or two segments with well-preserved liver function and who underwent SR between January 2006 and December 2013...
July 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28539038/-hepatobronchial-fistula-and-lung-abscess-after-transarterial-chemoembolization
#7
Kwanjoo Lee, Jeong Eun Song, Hyang Sook Jeong, Do Young Kim
Transarterial chemoembolization (TACE) is a common treatment modality to locally manage hepatocellular carcinoma. Liver abscess and bile duct injury are common complications of TACE. However, hepatobronchial fistula is a rare complication. Herein, we report a case of lung abscess due to hepatobronchial fistula after TACE. A 67-year-old man, who had underwent TACE 6 months ago, presented cough and bile-colored sputum. He was diagnosed with lung abscess and hepatobronchial fistula. We performed endoscopic retrograde cholangiopancreatography; however, there was no improvement in his symptoms...
May 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28537756/chemoembolization-adopting-polyethylene-glycol-drug-eluting-embolics-loaded-with-doxorubicin-for-the-treatment-of-hepatocellular-carcinoma
#8
Camillo Aliberti, Riccardo Carandina, Donatella Sarti, Luca Mulazzani, Enrico Pizzirani, Stefano Guadagni, Giammaria Fiorentini
OBJECTIVE: The purpose of this study is to determine the efficacy and tolerability of transarterial chemoembolization (TACE) using polyethylene glycol (PEG) drug-elutable microspheres loaded with doxorubicin for treatment of hepatocellular carcinoma (HCC). SUBJECTS AND METHODS: Forty-two patients with unresectable HCC, as determined by a tumor board, were assigned to undergo TACE and were treated with PEG drug-elutable embolics loaded with doxorubicin. Patients were prospectively enrolled and included 32 (76%) men and 10 (24%) women...
May 24, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28535652/-analysis-of-clinical-prognosis-and-the-correlation-between-bile-duct-injury-after-transcatheter-arterial-chemoembolization-and-the-level-of-hepatic-arterial-embolization-in-patients-with-hepatocellular-carcinoma
#9
H Y Xu, X P Yu, R Feng, H J Hu, W W Xiao
Objective: To evaluate the correlation between bile duct injury after transcatheter arterial chemoembolization and the level of hepatic arterial embolization, and to analyze the clinical prognosis of hepatocellular carcinoma patients. Methods: From January18, 2012 to December18, 2014, 21 patients underwent TACE for HCC were retrospectively reviewed, including patients' clinical and pathological data. The clinical outcome and relevant factors for bile duct injury were analyzed. Results: A total of 21 patients were identified with bile duct injury at our single institution...
May 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28535604/use-of-transcatheter-contrast-enhanced-ultrasound-with-vessel-navigation-to-reduce-the-contrast-requirement-during-transarterial-chemoembolization-in-patients-with-renal-impairment
#10
https://www.readbyqxmd.com/read/28534375/effect-of-the-combination-treatment-of-high-intensity-focused-ultrasound-and-cryocare-knife-in-advanced-liver-cancer
#11
Yuan-Peng Zhai, Yan Wang
PURPOSE: To analyze the effect of the combination treatment of high-intensity focused ultrasound (HIFU) and cryocare knife in advanced liver cancer. METHODS: 74 patients with advanced liver cancer were divided into the observation group (40 cases) and the control group (34 cases). Patients in the control group were treated with simple transcatheter arterial chemoembolization (TACE), while those in the observation group were given the combination treatment of HIFU and cryocare knife...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28534347/recent-perspectives-of-management-of-breast-cancer-metastasis-an-update
#12
Qingzhong Tian, Yun Wang, Hao Guo, Guangwei Xie, Jin Li, Minkang Zhang, Qianjin Zhang, Qingliang Meng
Breast cancer is the leading cause of cancer related deaths in women and one of the most common cancers globally. The major obstacle in the management of breast cancer, especially at advanced stages, is metastasis. Metastasis in the advanced stages of breast cancer could decrease survival to approximately 5 years. The reasons could include lack of targeted receptors or chemotherapeutic agents for the management of advanced-stage breast cancer metastasis. The new emerging avenues for the management of this deadly pathological state include local manipulations like radiofrequency ablation (RFA), microwave thermotherapy, cryosurgery (cryotherapy), chemoembolization, radioembolization, breast surgery, or metastasectomy...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28533801/computed-tomography-guided-implantation-of-125-i-seeds-brachytherapy-for-recurrent-multiple-pulmonary-oligometastases-initial-experience-and-results
#13
Jie Li, Lijuan Zhang, Wenhuan Xu, Teng Wang, Leyuan Zhou, Qigen Xie, Weiguo Wang, Yanyan Hua
PURPOSE: To retrospectively evaluate the efficacy and safety of computed tomography (CT)-guided percutaneous interstitial brachytherapy using (125)I radioactive seeds for multiple pulmonary metastatic tumors. MATERIAL AND METHODS: Between September 2013 and December 2015, 22 patients with multiple pulmonary metastases, who after conventional chemotherapy and trans-arterial chemoembolization (TACE) therapy were considered unable to withstand stereotactic body radiation therapy (SBRT), received CT-guided (125)I brachytherapy...
April 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28532743/doxorubicin-drug-eluting-embolic-chemoembolization-of-hepatocellular-carcinoma-study-of-midterm-doxorubicin-delivery-in-resected-liver-specimens
#14
Hadrien D'inca, Olivier Piot, Marie-Danièle Diebold, Tullio Piardi, Claude Marcus, Frédéric Burde, Daniele Sommacale, Michel Manfait, Gérard Thiéfin
This study evaluated the midterm delivery of doxorubicin in liver specimens from patients (N = 4) with hepatocellular carcinoma treated with drug-eluting embolic (DEE) transarterial chemoembolization. The patients had surgical resection 57, 79, 80 and 105 days after doxorubicin DEE chemoembolization. Doxorubicin concentrations inside embolic particles and in surrounding tissues were assessed by infrared microspectroscopy and microspectrofluorimetry, respectively. Embolic particles still contained doxorubicin and provided sustained drug delivery within targeted tissues 80 days after chemoembolization...
June 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28526069/xlf-mediated-nhej-activity-in-hepatocellular-carcinoma-therapy-resistance
#15
Sitian Yang, Xiao Qi Wang
BACKGROUND: DNA repair pathways are used by cancer cells to overcome many standard anticancer treatments, causing therapy resistance. Here, we investigated the role of XRCC4-like factor (XLF), a core member of the non-homologous end joining (NHEJ) repair pathway, in chemoresistance in hepatocellular carcinoma (HCC). METHODS: qRT-PCR analysis and western blotting were performed to detect expression levels of genes and proteins related to NHEJ. NHEJ repair capacity was assessed in vitro (cell-free) and in vivo by monitoring the activity of the NHEJ pathway...
May 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28524831/a-case-series-of-liver-abscess-formation-after-transcatheter-arterial-chemoembolization-for-hepatic-tumors
#16
Wei Sun, Fei Xu, Xiao Li, Chen-Rui Li
BACKGROUND: Liver abscess is a serious complication following transcatheter arterial chemoembolization (TACE). Much attention has been paid to this condition as it may interfere with the treatment process and result in a poor prognosis of the patient. This study aimed to analyze the causes of liver abscess, a complication, after TACE for hepatic tumors and to summarize management approaches. METHODS: From June 2012 to June 2014, of 1480 consecutive patients who underwent TACE at our hospital, five patients developed liver abscess after TACE procedures for hepatic tumors...
June 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28516133/transcatheter-arterial-chemoembolization-of-hepatocellular-carcinoma-in-patients-with-celiac-axis-occlusion-using-pancreaticoduodenal-arcade-as-a-challenging-alternative-route
#17
Noha M Attia, Moustafa H M Othman
INTRODUCTION: Celiac axis occlusion is a challenging condition when catheterization of the hepatic artery is required for chemoembolization of hepatocellular carcinoma (HCC). As a result, the hepatic artery has to be catheterized through the pancreaticoduodenal arcades (PDA) and the gastroduodenal artery (GDA) from the superior mesenteric artery (SMA) which is a tortuous course with acute angles and small caliber branches. OBJECTIVE: To assess new techniques for facilitating catheterization of the tortuous PDA and the GDA to reach the proper hepatic artery (PHA) and tumor-feeding branches in patients with celiac axis occlusion undergoing chemoembolization of HCC...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/28514219/science-to-practice-killing-dormant-cells-is-targeting-autophagy-the-key-to-complete-tumor-response-in-transarterial-chemoembolization
#18
Lynn Jeanette Savic, Julius Chapiro, Jean-François Geschwind
In this issue of Radiology, Gade et al ( 1 ) describe a unique mechanism of hepatocellular carcinoma (HCC) cells for surviving ischemia induced by transarterial embolization (TAE)/transarterial chemoembolization (TACE) in a state of cell cycle arrest-a function that may serve as a defensive shield against conventional chemotherapeutic agents. This finding adds to our knowledge and establishes a previously poorly understood mechanism of chemoresistance in HCC. As the Achilles heel in terms of this process, a concurrent upregulation of autophagic flux as an adaptive response to TAE-like ischemia was found by the authors...
June 2017: Radiology
https://www.readbyqxmd.com/read/28509806/advances-in-management-of-hepatocellular-carcinoma
#19
Manon Allaire, Jean-Charles Nault
PURPOSE OF REVIEW: Hepatocellular carcinoma (HCC) is one of the leading causes of death by cancer worldwide due to a dismal prognosis. The aim of this review is to summarize the main advances in the pathophysiology and management of HCC. RECENT FINDINGS: Genomic analysis has recently delineated the key signaling pathways aberrantly deregulated in HCC (telomere maintenance, cell cycle gene, Wnt/β-catenin, epigenetic modifier, oxidative stress etc.). Major advances in the clinical care of patients with HCC are helping to refine the diagnosis algorithm and tumor staging...
May 15, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28508831/dual-phase-cone-beam-computed-tomography-in-detecting-3-cm-hepatocellular-carcinomas-during-transarterial-chemoembolization
#20
Xiaodong Wang, Hooman Yarmohammadi, Guang Cao, Xinqiang Ji, Jungang Hu, Hirad Yarmohammadi, Hui Chen, Xu Zhu, Renjie Yang, Stephen B Solomon
OBJECTIVE: The objective of this study was to evaluate the sensitivity of dual phase cone-beam computed tomography (CBCT) in detecting small (<3 cm in diameter) hepatocellular carcinoma (HCC) tumors during transarterial chemoembolization (TACE). MATERIALS AND METHODS: Twenty-two consecutive patients with unresectable small HCCs in whom TACE was performed were retrospectively evaluated. Contrast CT or contrast magnetic resonance imaging (MRI) was performed in all patients within 1 month prior to the procedure...
January 2017: Journal of Cancer Research and Therapeutics
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