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Oesophageal cancer

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https://www.readbyqxmd.com/read/29244113/t1n0-oesophageal-cancer-patterns-of-care-and-outcomes-over-25-years
#1
Mohamed K Kamel, Benjamin Lee, Mohamed Rahouma, Sebron Harrison, Andrew B Nguyen, Jeffrey L Port, Nasser K Altorki, Brendon M Stiles
OBJECTIVES: Historically, surgical resection has been the mainstay of treatment for T1N0 oesophageal cancer (OC). More recently, oesophageal sparing endoscopic techniques have shown value for local control in a large institutional series. However, the effect of their utilization upon survival rates in large population series is largely unknown. METHODS: The surveillance, epidemiology, and end results (SEER) database was queried for T1N0M0-OC patients (1988-2013)...
December 13, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29243822/nrf2-promotes-oesophageal-cancer-cell-proliferation-via-metabolic-reprogramming-and-detoxification-of-reactive-oxygen-species
#2
Yuki Kitano, Yoshifumi Baba, Shigeki Nakagawa, Keisuke Miyake, Masaaki Iwatsuki, Takatsugu Ishimoto, Yo-Ichi Yamashita, Naoya Yoshida, Masayuki Watanabe, Mitsuyoshi Nakao, Hideo Baba
Cancer cells consume a large amount of energy and maintain high levels of anabolism to promote cell proliferation via metabolic reprogramming. Nuclear factor erythroid 2-related factor 2 (Nrf2; NFE2L2) is a master transcription regulator of stress responses and promotes metabolic reprogramming to support cell proliferation in various types of cancer. As oesophageal cancer is one of the most aggressive gastrointestinal cancers, we aimed to clarify the effect of Nrf2 on metabolic reprogramming in oesophageal cancer...
December 15, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/29243205/correction-to-a-phase-ii-study-evaluating-combined-neoadjuvant-cetuximab-and-chemotherapy-followed-by-chemoradiotherapy-and-concomitant-cetuximab-in-locoregional-oesophageal-cancer-patients
#3
Maria Alsina, Fernando Rivera, Francisco Javier Ramos, Maica Galán, Rafael López, Pilar García-Alfonso, José Enrique Alés-Martinez, Bernardo Queralt, Antonio Antón, Alfredo Carrato, Cristina Grávalos, Maria José Méndez-Vidal, Carlos López, Inmaculada Ruiz de Mena, Josep Tabernero, Jordi Giralt, Enrique Aranda
Errors were subsequently identified in the article and the following corrections should be noted.
December 14, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/29243145/the-first-consensus-statement-on-one-anastomosis-mini-gastric-bypass-oagb-mgb-using-a-modified-delphi-approach
#4
Kamal K Mahawar, Jacques Himpens, Scott A Shikora, Jean-Marc Chevallier, Mufazzal Lakdawala, Maurizio De Luca, Rudolf Weiner, Ali Khammas, Kuldeepak Singh Kular, Mario Musella, Gerhard Prager, Mohammad Khalid Mirza, Miguel Carbajo, Lilian Kow, Wei-Jei Lee, Peter K Small
BACKGROUND: An increasing number of surgeons worldwide are now performing one anastomosis/mini gastric bypass (OAGB/MGB). Lack of a published consensus amongst experts may be hindering progress and affecting outcomes. This paper reports results from the first modified Delphi consensus building exercise on this procedure. METHODS: A committee of 16 recognised opinion-makers in bariatric surgery with special interest in OAGB/MGB was constituted. The committee invited 101 OAGB/MGB experts from 39 countries to vote on 55 statements in areas of controversy or variation associated with this procedure...
December 14, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29237517/hypopharyngeal-cancer-associated-with-synchronous-oesophageal-cancer-risk-factors-and-benefits-of-image-enhanced-endoscopic-screening
#5
X-G Ni, Q-Q Zhang, J-Q Zhu, G-Q Wang
OBJECTIVES: To explore the risk factors associated with the occurrence of synchronous oesophageal cancer in patients with hypopharyngeal cancer, and to investigate the roles of image-enhanced endoscopic screening in the prediction and diagnosis of early oesophageal cancer. METHODS: The clinical characteristics of patients with hypopharyngeal cancer (n = 160) were analysed. All patients underwent laryngoscopic and gastroscopic examination using image-enhanced endoscopic techniques before treatment...
December 14, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29235564/influence-of-induction-chemotherapy-in-trimodality-therapy-eligible-oesophageal-cancer-patients-secondary-analysis-of-a-randomised-trial
#6
Yusuke Shimodaira, Rebecca S Slack, Kazuto Harada, Hsiang-Chun Chen, Tara Sagebiel, Manoop S Bhutani, Jeffrey H Lee, Brian Weston, Elena Elimova, Quan Lin, Fatemeh G Amlashi, Dilsa Mizrak Kaya, Mariela A Blum, Jack A Roth, Stephen G Swisher, Heath D Skinner, Wayne L Hofstetter, Jane E Rogers, Jaennette Mares, Irene Thomas, Dipen M Maru, Ritsuko Komaki, Garrett Walsh, Jaffer A Ajani
BACKGROUND: A randomised phase 2 trial of trimodality with or without induction chemotherapy (IC) in oesophageal cancer (EC) patients showed no advantage in overall survival (OS) or pathologic complete response rate. To identify subsets that might benefit from IC, a secondary analysis was done. METHODS: The trial had accrued 126 patients (NCT 00525915). Recursive partitioning and proportional hazards regression with interactions were performed. RESULTS: The median follow-up of surviving patients was 6...
December 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29235549/treatment-for-unresectable-or-metastatic-oesophageal-cancer-current-evidence-and-trends
#7
REVIEW
Peter S N van Rossum, Nadia Haj Mohammad, Frank P Vleggaar, Richard van Hillegersberg
Approximately half of the patients diagnosed with oesophageal cancer present with unresectable or metastatic disease. Treatment for these patients aims to control dysphagia and other cancer-related symptoms, improve quality of life and prolong survival. In the past 25 years, modestly improved outcomes have been achieved in the treatment of patients with inoperable non-metastatic cancer who are medically not fit for surgery or have unresectable, locally advanced disease. Concurrent chemoradiotherapy offers the best outcomes in these patients...
December 13, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29233813/a-case-of-isolated-bicuspid-pulmonary-valve
#8
Ramasamy Manivarmane, Rebecca Taylor, Rajdeep Khattar
We present a 73 years old woman who presented with pelvic cancer, ongoing sepsis and presumably a new diastolic murmur. Her transthoracic echocardiogram, as part of a sepsis screen, showed an abnormal pulmonary valve with moderate regurgitation. Trans-oesophageal echocardiography using 3D imaging showed a bicuspid pulmonary valve as the cause for the moderate regurgitation, but with no clear source of infection. Bicuspid pulmonary valve as an isolated clinical entity is a rare finding in clinical practice. Bicuspid pulmonary valves tend to be more commonly associated with other congenital cardiac anomalies...
December 12, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/29233736/fumonisin-b1-induces-oxidative-stress-in-oesophageal-sno-cancer-cells
#9
René B Khan, Alisa Phulukdaree, Anil A Chuturgoon
Fumonisin B1 (FB1) is a ubiquitous contaminant of maize that is epidemiologically linked to oesophageal cancer (OC) in South Africa. FB1-induced oxidative stress mediates toxicity in animals and human cell lines, but the effects relating to OC are limited. Given the species-specific effects of FB1, this study investigated FB1-mediated toxicity and oxidative stress in spindle-shaped N-cadherin (+) CD45 (-) osteoblastic (SNO) cells. Following exposure to FB1 (0-20 μM) for 48 h, mitochondrial membrane potential and intracellular reactive oxygen species (iROS) were measured (flow cytometry)...
December 9, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29228931/research-protocol-cisplatin-associated-ototoxicity-amongst-patients-receiving-cancer-chemotherapy-and-the-feasibility-of-an-audiological-monitoring-program
#10
J Paken, C D Govender, V Sewram
BACKGROUND: Cisplatin is an anti-cancer chemotherapy drug classified as an alkylating agent. It is used for the treatment of a variety of cancers such as cervical, breast, stomach, prostate, bladder and oesophageal, to name a few. However due to its expansive toxicity profile, patients receiving cisplatin can experience high frequency hearing loss, a side effect known as ototoxicity. The dearth of information on the extent and severity of cisplatin-associated ototoxicity in South Africa prevents the implementation of a context-specific audiological monitoring programme...
December 11, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29226326/retreg1-fam134b-a-new-player-in-human-diseases-15-years-after-the-discovery-in-cancer
#11
REVIEW
Farhadul Islam, Vinod Gopalan, Alfred King-Yin Lam
FAM134B (family with sequence similarity 134, member B) / RETREG1 and its functional roles are relatively new in human diseases. This review aimed to summarize various functions of FAM134B since our first discovery of the gene in 2001. The protein encoded by FAM134B is a reticulophagy receptor that regulates turnover of the endoplasmic reticulum (ER) by selective phagocytosis. Absence or non-functional expression of FAM134B protein impairs ER-turnover and thereby is involved in the pathogenesis of some human diseases...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29221240/composite-metrics-in-response-assessment-new-hope-in-oesophageal-cancer
#12
EDITORIAL
Janusz Włodarczyk, Jarosław Kużdżał
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221227/pet-guided-treatment-algorithms-in-oesophageal-cancer-the-promise-of-the-near-future
#13
EDITORIAL
Lioe-Fee de Geus-Oei, Marije Slingerland
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221150/comparison-of-gross-tumor-volume-of-primary-oesophageal-cancer-based-on-contrast-enhanced-three-dimensional-four-dimensional-and-cone-beam-computed-tomography
#14
Chao-Yue Hu, Jian-Bin Li, Jin-Zhi Wang, Wei Wang, Feng-Xiang Li, Yan-Luan Guo
Background: To explore motion information included in 3DCT, 4DCT and CBCT by comparing volumetric and positional differences of GTV. Results: Independent of tumor location, significant differences were observed among volumes [IGTV10 > (IGTVCBCT or IGTVMIP) > (GTV3D or GTV4D50)]. The underestimations or overestimations between IGTV10 and IGTVCBCT were larger than those between IGTV10 and IGTVMIP (p < 0.001-0.011; p < 0.001-0.023). For upper oesophageal tumors, GTV4D50/IGTVCBCT negatively correlated with motion vector (r = -0...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29218619/cervical-ultrasonography-has-no-additional-value-over-negative-18f-fdg-pet-ct-scans-for-diagnosing-cervical-lymph-node-metastases-in-patients-with-oesophageal-cancer
#15
Lucas Goense, Jihane Meziani, Peter S N van Rossum, Frank J Wessels, Marnix G E H Lam, Richard van Hillegersberg, Jelle P Ruurda
OBJECTIVES: To investigate the additional value of cervical ultrasonography over 18F-FDG PET/CT for diagnosing cervical lymph node metastases in patients with newly diagnosed oesophageal cancer. METHODS: Between January 2013 and January 2016, 163 patients with newly diagnosed oesophageal cancer underwent both cervical ultrasonography and 18F-FDG PET/CT at a tertiary referral centre in the Netherlands. Retrospective clinical data analysis was performed to assess the diagnostic value of cervical ultrasonography and 18F-FDG PET/CT for the detection of cervical lymph node metastases...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29216650/-have-multimodal-and-perioperative-therapeutic-strategies-changed-the-survival-after-oncological-oesophageal-surgery-in-the-last-two-decades-a-retrospective-cohort-analysis-over-23-years
#16
Philipp Lingohr, Julia Zender, Cornelius van Beekum, Jonas Dohmen, Hanno Matthaei, Nico Schaefer, Jörg C Kalff, Tim Oliver Vilz
Background Esophageal malignoma is among the most frequent causes for cancer-related deaths. The only definite curative therapy is esophagectomy embedded in various multimodal treatment regimens. The aim of this study was to evaluate long-term development after esophageal surgery in the last two decades in order to observe possible trends and their influence on short, medium and long term survival. Patients and Methods Cases of 301 patients who underwent esophagectomy between 1989 and 2012 were analysed retrospectively...
December 7, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29216556/influence-of-water-activity-and-temperature-on-growth-and-fumonisin-production-by-fusarium-proliferatum-strains-on-irradiated-wheat-grains
#17
Eugenia Cendoya, María Del Pilar Monge, Stella Maris Chiacchiera, María Cecilia Farnochi, María Laura Ramirez
Wheat is the most important cereal consumed by the Argentine population. In previous studies performed in durum and common wheat grains in this country it has been observed fumonisin contamination as well as high incidence of Fusarium proliferatum. Fumonisins are toxic fungal metabolites, and consumption of fumonisin-contaminated maize has been epidemiologically associated with oesophageal cancer and neural tube defects in some human populations. Using irradiated wheat-grains, the effects of abiotic factors, temperature (15, 25, and 30°C) and water activity (aW; 0...
December 4, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29212656/the-relevance-and-implications-of-signet-ring-cell-adenocarcinoma-of-the-oesophagus
#18
REVIEW
Christopher William Bleaney, Mickhaiel Barrow, Stephen Hayes, Yeng Ang
AIM: To review the current understanding of signet-ring type oesophageal adenocarcinoma including evidence for prognosis. METHODS: We conducted a literature search of nine healthcare literature databases for articles detailing the biology and clinical outcomes of signet-ring cell adenocarcinoma of the oesophagus. The impact of signet-ring cell morphology was analysed and detailed in written text and tabular format. Current understanding of the biology of signet-ring cell adenocarcinoma of the oesophagus was summarised...
December 6, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29211685/optimisation-of-sampling-parameters-for-standardised-exhaled-breath-sampling
#19
Sophie L F Doran, Andrea Romano, George B Hanna
The lack of standardisation of breath sampling is a major contributing factor to the poor repeatability of results and hence represents a barrier to the adoption of breath tests in clinical practice. On-line and bag breath sampling have advantages but do not suit multicentre clinical studies whereas storage and robust transport are essential for the conduct of wide-scale studies. Several devices have been developed to control sampling parameters and to concentrate volatile organic compounds (VOCs) onto thermal desorption (TD) tubes and subsequently transport those tubes for laboratory analysis...
December 6, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29209536/activating-her2-mutations-as-emerging-targets-in-multiple-solid-cancers
#20
REVIEW
Claire M Connell, Gary J Doherty
The epidermal growth factor receptor (EGFR) family of transmembrane receptor tyrosine kinases activates signalling pathways regulating cellular proliferation and survival. HER2 is a non-ligand-binding member of this family and exerts its activity through heterodimerisation with other EGFR family members. HER2 functional activation promotes oncogenesis, leading to the investigation of HER2-directed agents in cancers with HER2 alterations. This has been best characterised in the context of HER2 gene amplification in breast and gastro-oesophageal cancers, for which HER2-directed drugs form part of standard treatment regimens...
2017: ESMO Open
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