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https://www.readbyqxmd.com/read/28931012/cbta-toxin-of-escherichia-coli-inhibits-cell-division-and-cell-elongation-via-direct-and-independent-interactions-with-ftsz-and-mreb
#1
Danielle M Heller, Mrinalini Tavag, Ann Hochschild
The toxin components of toxin-antitoxin modules, found in bacterial plasmids, phages, and chromosomes, typically target a single macromolecule to interfere with an essential cellular process. An apparent exception is the chromosomally encoded toxin component of the E. coli CbtA/CbeA toxin-antitoxin module, which can inhibit both cell division and cell elongation. A small protein of only 124 amino acids, CbtA, was previously proposed to interact with both FtsZ, a tubulin homolog that is essential for cell division, and MreB, an actin homolog that is essential for cell elongation...
September 20, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28927497/decision-to-delivery-time-and-perinatal-complications-in-emergency-cesarean-section
#2
Günther Heller, Erik Bauer, Stefanie Schill, Teresa Thomas, Frank Louwen, Friedrich Wolff, Björn Misselwitz, Stephan Schmidt, Christof Veit
BACKGROUND: A decision-to-delivery interval (DDI) of no more than 20 minutes has long been considered a requirement for cesarean sections, even though there have hardly been any studies on this topic. We retrospectively investigated data relevant to DDI for emergency cesarean sections performed for the most common indications, namely, suspected and documented fetal asphyxia. METHODS: We analyzed data on emergency in-hospital cesarean sections in the period 2008-2015...
September 4, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28924729/dor-vs-toupet-fundoplication-after-laparoscopic-heller-myotomy-long-term-randomized-controlled-trial-evaluated-by-high-resolution-manometry
#3
Gonzalo Torres-Villalobos, Enrique Coss-Adame, Janette Furuzawa-Carballeda, Fernanda Romero-Hernández, Blanca Blancas-Breña, Samuel Torres-Landa, Axel Palacios-Ramírez, Edgar Alejandro-Medrano, Axel Hernández-Ávila, Athenea Flores-Najera, Lourdes Margarita Ávila Escobedo, Cecilia Ramírez Angulo, Angélica Rodríguez-Garcés, Miguel Ángel Valdovinos
BACKGROUND: Laparoscopic Heller myotomy (LHM) with partial fundoplication is an effective treatment for achalasia. However, the type of fundoplication is still a subject of debate. AIM: The aim of the study is to identify which partial fundoplication leads to better control of acid exposure, manometric parameters, and symptoms scores. METHODS: A randomized controlled trial was performed to compare Dor vs Toupet fundoplication after LHM. The preoperative diagnosis was made by high-resolution manometry (HRM), upper endoscopy, and barium esophagogram...
September 18, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28924200/controllable-moderate-heating-enhances-the-therapeutic-efficacy-of-irreversible-electroporation-for-pancreatic-cancer
#4
Chelsea M Edelblute, James Hornef, Niculina I Burcus, Thomas Norman, Stephen J Beebe, Karl Schoenbach, Richard Heller, Chunqi Jiang, Siqi Guo
Irreversible electroporation (IRE) as a non-thermal tumor ablation technology has been studied for the treatment of pancreatic carcinoma and has shown a significant survival benefit. We discovered that moderate heating (MH) at 43 °C for 1-2 minutes significantly enhanced ex vivo IRE tumor ablation of Pan02 cells by 5.67-fold at 750 V/cm and by 1.67-fold at 1500 V/cm. This amount of heating alone did not cause cell death. An integrated IRE system with controllable laser heating and tumor impedance monitoring was developed to treat mouse ectopic pancreatic cancer...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28919967/comparative-analysis-of-chromosomes-in-the-palaearctic-bush-crickets-of-tribe-pholidopterini-orthoptera-tettigoniinae
#5
Elżbieta Warchałowska-Śliwa, Beata Grzywacz, Klaus-Gerhard Heller, Dragan P Chobanov
The present study focused on the evolution of the karyotype in four genera of the tribe Pholidopterini: Eupholidoptera Mařan, 1953, Parapholidoptera Mařan, 1953, Pholidoptera Wesmaël, 1838, Uvarovistia Mařan, 1953. Chromosomes were analyzed using fluorescence in situ hybridization (FISH) with 18S rDNA and (TTAGG) n telomeric probes, and classical techniques, such as C-banding, silver impregnation and fluorochrome DAPI/CMA3 staining. Most species retained the ancestral diploid chromosome number 2n = 31 (male) or 32 (female), while some of the taxa, especially a group of species within genus Pholidoptera, evolved a reduced chromosome number 2n = 29...
2017: Comparative Cytogenetics
https://www.readbyqxmd.com/read/28919276/-focus-on-achalasia
#6
Marie-Anne Guillaumot, Maximilien Barret, Sarah Leblanc, Mahaut Leconte, Bertrand Dousset, Ammar Oudjit, Frédéric Prat, Stanislas Chaussade
The pathophysiology of achalasia is largely unknown, and involves the destruction of ganglion cell in the esophageal myenteric plexus. High-resolution esophageal manometry is the key investigation. Endoscopic pneumodilatation and laparoscopic Heller myotomy have comparable short-term success rates, around 90%. The main complication after pneumodilatation is esophageal perforation, occurring in about 1% of cases. Peroral endoscopic myotomy is a promising treatment modality, however with frequent post-procedural gastroesophageal reflux...
September 14, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28918990/long-term-metabolic-persistence-of-gram-positive-bacteria-on-health-care-relevant-plastic
#7
Loree C Heller, Chelsea M Edelblute
BACKGROUND: Health care-associated opportunistic pathogens Staphylococcus aureus and Enterococcus faecium persist on dry environments and can contribute to organism transmission through contact. These organisms can be monitored on surfaces by culture, molecular methods, or metabolic assays. This study was designed to determine the kinetics of bacterial persistence on acrylonitrile butadiene styrene, a plastic commonly used in the manufacture of bedrails. MATERIALS AND METHODS: Polymerase chain reaction for genomic DNA was used to confirm the presence of bacteria cells on this plastic irrespective of viability...
September 14, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28914670/endometrial-stromal-neoplasm-in-the-placenta-report-of-a-case-and-review-of-the-literature
#8
Debra S Heller, Fadi Hatem
Placental neoplasms involving the fetal membranes are exceptionally rare. In leiomyomas and endometrial stromal neoplasms, a uterine origin for nodules in the membranes is also a possibility. We present a case of an incidental endometrial stromal nodule found in the decidua of the free membranes and review the literature.
September 13, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28913543/devote-3-temporal-relationships-between-severe-hypoglycaemia-cardiovascular-outcomes-and-mortality
#9
Thomas R Pieber, Steven P Marso, Darren K McGuire, Bernard Zinman, Neil R Poulter, Scott S Emerson, Richard E Pratley, Vincent Woo, Simon Heller, Martin Lange, Kirstine Brown-Frandsen, Alan Moses, Jesper Barner Lekdorf, Lucine Lehmann, Kajsa Kvist, John B Buse
AIMS/HYPOTHESIS: The double-blind Trial Comparing Cardiovascular Safety of Insulin Degludec vs Insulin Glargine in Patients with Type 2 Diabetes at High Risk of Cardiovascular Events (DEVOTE) assessed the cardiovascular safety of insulin degludec. The incidence and rates of adjudicated severe hypoglycaemia, and all-cause mortality were also determined. This paper reports a secondary analysis investigating associations of severe hypoglycaemia with cardiovascular outcomes and mortality...
September 15, 2017: Diabetologia
https://www.readbyqxmd.com/read/28905682/management-of-post-traumatic-phlegmasia-cerulea-dolens-via-right-to-left-femoral-vein-to-femoral-vein-bypass-palma-procedure
#10
Anahita Dua, Jennifer Heller, Cheong Lee
Phlegmasia cerulea dolens (PCD) is a rare condition resulting from venous occlusion that impairs arterial flow. We report a rare case of post-traumatic PCD after ligation of the iliac vein with successful treatment by right-to-left femoral vein to femoral vein bypass using left great saphenous vein (Palma procedure). The clinical presentation, diagnostic process, and approach to management along with a literature review on the operative management of PCD are presented in this case report.
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28904979/the-russians-are-the-fastest-in-marathon-cross-country-skiing-the-engadin-ski-marathon
#11
Pantelis Theodoros Nikolaidis, Jan Heller, Beat Knechtle
It is well known that athletes from a specific region or country are dominating certain sports disciplines such as marathon running or Ironman triathlon; however, little relevant information exists on cross-country skiing. Therefore, the aim of the present study was to investigate the aspect of region and nationality in one of the largest cross-country skiing marathons in Europe, the "Engadin Ski Marathon." All athletes (n = 197,125) who finished the "Engadin Ski Marathon" between 1998 and 2016 were considered...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28903893/user-acceptance-of-computerized-cognitive-behavioral-therapy-for-depression-systematic-review
#12
Theresia Rost, Janine Stein, Margrit Löbner, Anette Kersting, Claudia Luck-Sikorski, Steffi G Riedel-Heller
BACKGROUND: Computerized cognitive behavioral therapy (cCBT) has been proven to be effective in depression care. Moreover, cCBT packages are becoming increasingly popular. A central aspect concerning the take-up and success of any treatment is its user acceptance. OBJECTIVE: The aim of this study was to update and expand on earlier work on user acceptance of cCBT for depression. METHODS: This paper systematically reviewed quantitative and qualitative studies regarding the user acceptance of cCBT for depression...
September 13, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28903646/communal-and-agentic-interpersonal-and-intergroup-motives-predict-preferences-for-status-versus-power
#13
Kenneth D Locke, Sonja Heller
Seven studies involving 1,343 participants showed how circumplex models of social motives can help explain individual differences in preferences for status (having others' admiration) versus power (controlling valuable resources). Studies 1 to 3 and 7 concerned interpersonal motives in workplace contexts, and found that stronger communal motives (to have mutual trust, support, and cooperation) predicted being more attracted to status (but not power) and achieving more workplace status, while stronger agentic motives (to be firm, decisive, and influential) predicted being more attracted to and achieving more workplace power, and experiencing a stronger connection between workplace power and job satisfaction...
January 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28902959/insight-into-the-activation-of-in-situ-generated-chiral-rh-i-catalysts-and-their-application-in-cyclotrimerizations
#14
Indre Thiel, Moritz Horstmann, Phillip Jungk, Sonja Keller, Fabian Fischer, Hans-Joachim Drexler, Detlef Heller, Marko Hapke
The generation of highly active chiral catalysts at mild temperatures for [2+2+2] cycloaddition reactions is a requirement for high conversions as well as selectivities with selected examples giving up to 96% ee in single cases. We herein report a detailed study on the generation of [Rh(diphosphine)(solvent)]+ complexes as catalysts for cyclotrimerizations, with single examples applying the ((Sc,Rp)-Duanphos) ligand giving up to 96% ee selectivity in single cases. Novel ammonia complexes of the type [Rh(diphosphine)(NH3)2]+ were also successfully tested for the generation of the highly reactive solvent complexes...
September 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28902413/frequent-genes-in-rare-diseases-panel-based-next-generation-sequencing-to-disclose-causal-mutations-in-hereditary-neuropathies
#15
Maike F Dohrn, Nicola Glöckle, Lejla Mulahasanovic, Corina Heller, Julia Mohr, Christine Bauer, Erik Riesch, Andrea Becker, Florian Battke, Konstanze Hörtnagel, Thorsten Hornemann, Saranya Suriyanarayanan, Markus Blankenburg, Jörg B Schulz, Kristl G Claeys, Burkhard Gess, Istvan Katona, Andreas Ferbert, Debora Vittore, Alexander Grimm, Stefan Wolking, Ludger Schöls, Holger Lerche, G Christoph Korenke, Dirk Fischer, Bertold Schrank, Urania Kotzaeridou, Gerhard Kurlemann, Bianca Dräger, Anja Schirmacher, Peter Young, Beate Schlotter-Weigel, Saskia Biskup
Hereditary neuropathies comprise a wide variety of chronic diseases associated to more than 80 genes identified to date. We herein examined 612 index patients with either a Charcot-Marie-Tooth phenotype, hereditary sensory neuropathy, familial amyloid neuropathy, or small fiber neuropathy using a customized multigene panel based on the next generation sequencing (NGS) technique. In 121 cases (19.8%), we identified at least one putative pathogenic mutation. Out of these, 54.4% showed an autosomal dominant, 33...
September 13, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28898580/self-assembled-cu-sn-s-nanotubes-with-high-de-lithiation-performance
#16
Jie Lin, Jin-Myoung Lim, Duck Hyun Youn, Kenta Kawashima, Jun-Hyuk Kim, Yang Liu, Hang Guo, Graeme Henkelman, Adam Heller, Charles Buddie Mullins
Through a gelation-solvothermal method without hetero-additives, Cu-Sn-S composites self-assemble to form nanotubes, sub-nanotubes and nanoparticles. The nanotubes with Cu3-4SnS4 core and Cu2SnS3 shell can tolerate long cycles of expansion/contraction upon lithiation/delithiation, retaining a charge capacity of 774 mAh g-1 after 200 cycles with a high initial coulombic efficiency of 82.5%. The importance of the Cu component for mitigation of the volume expansion and structural evolution upon lithiation is informed by density functional theory calculations...
September 12, 2017: ACS Nano
https://www.readbyqxmd.com/read/28898055/a-carbon-nanotube-optical-reporter-maps-endolysosomal-lipid-flux
#17
Prakrit V Jena, Daniel Roxbury, Thomas V Galassi, Leila Akkari, Christopher P Horoszko, David B Iaea, Januka Budhathoki-Uprety, Nina Pipalia, Abigail S Haka, Jackson D Harvey, Jeetain Mittal, Frederick R Maxfield, Johanna A Joyce, Daniel A Heller
Lipid accumulation within the lumen of endolysosomal vesicles is observed in various pathologies including atherosclerosis, liver disease, neurological disorders, lysosomal storage disorders, and cancer. Current methods cannot measure lipid flux specifically within the lysosomal lumen of live cells. We developed an optical reporter, composed of a photoluminescent carbon nanotube of a single chirality, that responds to lipid accumulation via modulation of the nanotube's optical band gap. The engineered nanomaterial, composed of short, single-stranded DNA and a single nanotube chirality, localizes exclusively to the lumen of endolysosomal organelles without adversely affecting cell viability or proliferation or organelle morphology, integrity, or function...
September 12, 2017: ACS Nano
https://www.readbyqxmd.com/read/28895963/small-angle-neutron-scattering-study-of-a-dense-microemulsion-system-formed-with-an-ionic-liquid
#18
T Kang, S Qian, G S Smith, C Do, W T Heller
Mixtures of water, octane and 1-octanol with 1-tetradecyl-3-methylimidazolium chloride (C14MIM·Cl), often referred to as a surface active ionic liquid (SAIL), form water-in-oil microemulsions that have potential application as extraction media for various metal ions. Here, we present a structural study by small-angle neutron scattering (SANS) of dense microemulsions formed by surfactant-rich mixtures of these four compounds to understand how the SAIL can be used to tune the structures and properties of the microemulsions...
September 12, 2017: Soft Matter
https://www.readbyqxmd.com/read/28895383/robotic-assisted-thoracoscopic-lung-surgery-anesthetic-impact-and-perioperative-experience
#19
Joshua A Heller, Fraiz Y Bhora, Benjamin J Heller, Edmond Cohen
Anesthesiologists and the perioperative team have a tremendous impact upon clinical outcomes in robotic-assisted thoracoscopic surgery. As anesthesiology is developing its role outside the operating room, the patient population benefits from an expanded focus on perioperative critical care and pain management. This review focuses upon the preoperative optimization, unique intraoperative considerations for surgeons and anesthesiologists, and postoperative management of patients undergoing robotic-assisted thoracoscopic surgery...
September 11, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28893459/placing-the-patient-at-the-centre-of-chronic-wound-care-a-qualitative-evidence-synthesis
#20
REVIEW
Naomi Fearns, Stephen Heller-Murphy, Joanna Kelly, Jenny Harbour
BACKGROUND: Chronic wounds are a major health burden and have a severe impact on well-being. This synthesis of qualitative studies was undertaken to inform a health technology assessment of antimicrobial wound dressings. It aimed to explore patients' experiences of chronic wounds and determine improvements for clinical practice. METHOD: Inclusion criteria included use of qualitative methods, and English language publication. Databases searched included MEDLINE (Ovid), MEDLINE in Process (Ovid), EMBASE (Ovid), CINAHL (EBSCOHost), and PsychInfo (EBSCOHost)...
September 5, 2017: Journal of Tissue Viability
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