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https://www.readbyqxmd.com/read/28088111/psychometric-evaluation-of-the-generalized-anxiety-disorder-screener-gad-7-based-on-a-large-german-general-population-sample
#1
Andreas Hinz, Annette M Klein, Elmar Brähler, Heide Glaesmer, Tobias Luck, Steffi G Riedel-Heller, Kerstin Wirkner, Anja Hilbert
BACKGROUND: The Generalized Anxiety Disorder Scales GAD-7 and GAD-2 are instruments for the assessment of anxiety. The aims of this study are to test psychometric properties of these questionnaires, to provide normative values, and to investigate associations with sociodemographic factors, quality of life, psychological variables, and behavioral factors. METHODS: A German community sample (n=9721) with an age range of 18-80 years was surveyed using the GAD-7 and several other questionnaires...
December 18, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28077321/camkii%C3%AE-subtypes-differentially-regulate-infarct-formation-following-ex-vivo-myocardial-ischemia-reperfusion-through-nf-%C3%AE%C2%BAb-and-tnf-%C3%AE
#2
Charles B B Gray, Takeshi Suetomi, Sunny Xiang, Erik A Blackwood, Christopher C Glembotski, Shigeki Miyamoto, B Daan Westenbrink, Joan Heller Brown
Deletion of Ca(2+/)calmodulin-dependent protein kinase II delta (CaMKIIδ) has been shown to protect against in vivo ischemia/reperfusion (I/R) injury. It remains unclear which CaMKIIδ isoforms and downstream mechanisms are responsible for the salutary effects of CaMKIIδ gene deletion. In this study we sought to compare the roles of the CaMKIIδB and CaMKIIδC subtypes and the mechanisms by which they contribute to ex vivo I/R damage. WT, CaMKIIδKO, and mice expressing only CaMKIIδB or δC were subjected to ex vivo global ischemia for 25min followed by reperfusion...
January 7, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28074540/complications-of-percutaneous-liver-biopsy-with-klatskin-needles-a-36-year-single-centre-experience
#3
V Takyar, O Etzion, T Heller, D E Kleiner, Y Rotman, M G Ghany, N Fryzek, V H Williams, E Rivera, S Auh, T J Liang, J H Hoofnagle, C Koh
BACKGROUND: Liver biopsy is the gold standard in evaluating liver diseases but is susceptible to complications. Safety data on aspiration needle biopsies remain limited. AIM: To evaluate the safety of percutaneous liver biopsy performed with Klatskin needle. METHODS: Clinical and biochemical data were retrospectively retrieved from sequential subjects who underwent liver biopsy with Klatskin needle from 1978 to 2015. Subjects with complications underwent thorough chart reviews for hospital course...
January 10, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28073320/early-recovery-of-t-cell-function-predicts-improved-survival-after-t-cell-depleted-allogeneic-transplant
#4
Jenna D Goldberg, Junting Zheng, Ravin Ratan, Trudy N Small, Kuan-Chi Lai, Farid Boulad, Hugo Castro-Malaspina, Sergio A Giralt, Ann A Jakubowski, Nancy A Kernan, Richard J O'Reilly, Esperanza B Papadopoulos, James W Young, Marcel R M van den Brink, Glenn Heller, Miguel-Angel Perales
Infection, relapse, and GVHD can complicate allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although the effect of poor immune recovery on infection risk is well-established, there are limited data on the effect of immune reconstitution on relapse and survival, especially following T-cell depletion (TCD). To characterize the pattern of immune reconstitution in the first year after transplant and its effects on survival and relapse, we performed a retrospective study in 375 recipients of a myeloablative TCD allo-HSCT for hematologic malignancies...
January 10, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28068477/spatial-variability-and-uncertainty-of-water-use-impacts-from-us-feed-and-milk-production
#5
Andrew D Henderson, Anne Claire Asselin-Balençon, Martin C Heller, Lindsay Lessard, Samuel Vionnet, Olivier Jolliet
This paper addresses water use impacts of agriculture, developing a spatially-explicit approach tracing the location of water use and water scarcity related to feed production, transport, and livestock, tracking uncertainties and illustrating the approach with a case study on dairy production in the United States. This approach was developed as a step to bring spatially-variable production and impacts into a process-based Life Cycle Assessment (LCA) context. As water resources and demands are spatially variable, it is critical to take into account the location of activities to properly understand the impacts of water use, accounting for each of the main feeds for milk production...
January 9, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28063280/principles-of-protein-structural-ensemble-determination
#6
REVIEW
Massimiliano Bonomi, Gabriella T Heller, Carlo Camilloni, Michele Vendruscolo
The biological functions of protein molecules are intimately dependent on their conformational dynamics. This aspect is particularly evident for disordered proteins, which constitute perhaps one-third of the human proteome. Therefore, structural ensembles often offer more useful representations of proteins than individual conformations. Here, we describe how the well-established principles of protein structure determination should be extended to the case of protein structural ensembles determination. These principles concern primarily how to deal with conformationally heterogeneous states, and with experimental measurements that are averaged over such states and affected by a variety of errors...
January 4, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/28062993/the-discovery-of-caligus-macrurus-heller-1865-copepoda-caligidae-in-the-mediterranean-sea-and-the-recognition-of-sciaenophilus-van-beneden-1852-as-a-junior-synonym-of-caligus-m%C3%A3-ller-1785
#7
Argun Akif Özak, Alper Yanar, Geoffrey Allan Boxshall
The siphonostomatoid parasitic copepod Caligus macrurus Heller, 1865 is redescribed based on new material collected from the gill filaments and pharynx of tripletail Lobotes surinamensis Bloch (Lobotidae) caught in Iskenderun Bay, Turkey. Key diagnostic characters and newly observed taxonomic features are reported, supported by light and scanning electron microscopy observations. This is the first report of C. macrurus from Mediterranean waters. Caligus macrurus is also recognised as conspecific with the better known Caligus bennetti Causey, 1953, found on the same host, which becomes a junior subjective synonym of C...
January 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28061965/report-of-the-acr-s-economics-committee-on-value-based-payment-models
#8
Giles W Boland, Lucille Glenn, Shlomit Goldberg-Stein, Saurabh Jha, Mark Mangano, Samir Patel, Kurt A Schoppe, David Seidenwurm, John Lohnes, Ezequiel Silva, Richard Abramson, Daniel J Durand, Laura Pattie, Pamela Kassing, Richard E Heller
A major outcome of the current health care reform process is the move away from unrestricted fee-for-service payment models toward those that are based on the delivery of better patient value and outcomes. The authors' purpose, therefore, is to critically evaluate and define those components of the overall imaging enterprise that deliver meaningful value to both patients and referrers and to determine how these components might be measured and quantified. These metrics might then be used to lobby providers and payers for sustainable payment solutions for radiologists and radiology services...
January 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28058763/relationship-of-glycated-haemoglobin-and-reported-hypoglycaemia-to-cardiovascular-outcomes-in-patients-with-type-2-diabetes-and-recent-acute-coronary-syndromes-the-examine-trial
#9
Simon R Heller, Richard M Bergenstal, William B White, Stuart Kupfer, George L Bakris, William C Cushman, Cyrus R Mehta, Steven E Nissen, Craig A Wilson, Faiez Zannad, Yuyin Liu, Noah M Gourlie, Christopher P Cannon
AIMS: To investigate relationships between glycated haemoglobin (HbA1c) and reported hypoglycaemia and risk of major adverse cardiovascular (CV) events (MACE). METHODS: The EXAMINE trial randomized 5380 patients in 49 countries with type 2 diabetes (T2DM) and a recent acute coronary syndrome (ACS) to double-blind treatment with alogliptin or placebo in addition to standard of care. We used Cox proportional hazards models to analyze relationships among MACE, HbA1c levels and hypoglycaemia events...
January 6, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28052922/who-s-that-knocking-at-my-door-neural-bases-of-sound-source-identification
#10
Guillaume Lemaitre, John A Pyles, Andrea R Halpern, Nicole Navolio, Matthew Lehet, Laurie M Heller
When hearing knocking on a door, a listener typically identifies both the action (forceful and repeated impacts) and the object (a thick wooden board) causing the sound. The current work studied the neural bases of sound source identification by switching listeners' attention toward these different aspects of a set of simple sounds during functional magnetic resonance imaging scanning: participants either discriminated the action or the material that caused the sounds, or they simply discriminated meaningless scrambled versions of them...
January 3, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28052278/diagnosis-and-treatment-strategy-of-achalasia-subtypes-and-esophagogastric-junction-outflow-obstruction-based-on-high-resolution-manometry
#11
Eikichi Ihara, Kazumasa Muta, Keita Fukaura, Kazuhiko Nakamura
BACKGROUND: Based on Chicago Classification version 3.0, the disorders of esophagogastric junction outflow obstruction (EGJOO) include achalasia (types I, II and III) and EGJOO. Although no curative treatments are currently available for the treatment of the disorders of EGJOO, medical treatments, endoscopic pneumatic dilation (PD), laparoscopic Heller myotomy (LHM), and per-oral endoscopic myotomy (POEM) are usually the sought-after modes of treatment. Since the etiology and pathogenesis might vary depending on the types of EGJOO disorders, treatment strategies should be considered based on those subtypes...
2017: Digestion
https://www.readbyqxmd.com/read/28049219/-computer-based-therapies-a-supplement-in-modern-psychotherapy-pro
#12
Steffi G Riedel-Heller
No abstract text is available yet for this article.
January 2017: Psychiatrische Praxis
https://www.readbyqxmd.com/read/28049217/-the-most-cited-articles-in-volume-41-of-psychiatrische-praxis-congratulations
#13
Philipp Reimann, Steffi G Riedel-Heller
No abstract text is available yet for this article.
January 2017: Psychiatrische Praxis
https://www.readbyqxmd.com/read/28041809/mission-possible-successful-careers-in-adult-cardiothoracic-anesthesiology-what-i-wish-i-had-known-in-the-first-5-years-after-fellowship
#14
Madhav Swaminathan, Kathryn E Glas, Lori Heller, John G T Augoustides, William C Culp, Roman M Sniecinski
No abstract text is available yet for this article.
October 14, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28039638/effects-of-laparoscopic-myotomy-on-the-esophageal-motility-pattern-of-esophageal-achalasia-as-measured-by-high-resolution-manometry
#15
Renato Salvador, Edoardo Savarino, Elisa Pesenti, Lorenzo Spadotto, Guerrino Voltarel, Giovanni Capovilla, Francesco Cavallin, Loredana Nicoletti, Michele Valmasoni, Alberto Ruol, Stefano Merigliano, Mario Costantini
BACKGROUND: Esophageal achalasia can be classified on the grounds of three distinct manometric patterns that correlate well with final outcome after laparoscopic Heller-Dor myotomy (LHM). No analytical data are available, however, on the postoperative picture and its possible correlation with final outcome. The aims of this study were: (a) to investigate whether manometric patterns change after LHM for achalasia; (b) to ascertain whether postoperative patterns and/or changes can predict final outcome; and (c) to test the hypothesis that the three known patterns represent different stages in the evolution of the disease...
December 30, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/28039433/structural-characterization-of-nonactive-site-trka-selective-kinase-inhibitors
#16
Hua-Poo Su, Keith Rickert, Christine Burlein, Kartik Narayan, Marina Bukhtiyarova, Danielle M Hurzy, Craig A Stump, Xufang Zhang, John Reid, Alicja Krasowska-Zoladek, Srivanya Tummala, Jennifer M Shipman, Maria Kornienko, Peter A Lemaire, Daniel Krosky, Amanda Heller, Abdelghani Achab, Chad Chamberlin, Peter Saradjian, Berengere Sauvagnat, Xianshu Yang, Michael R Ziebell, Elliott Nickbarg, John M Sanders, Mark T Bilodeau, Steven S Carroll, Kevin J Lumb, Stephen M Soisson, Darrell A Henze, Andrew J Cooke
Current therapies for chronic pain can have insufficient efficacy and lead to side effects, necessitating research of novel targets against pain. Although originally identified as an oncogene, Tropomyosin-related kinase A (TrkA) is linked to pain and elevated levels of NGF (the ligand for TrkA) are associated with chronic pain. Antibodies that block TrkA interaction with its ligand, NGF, are in clinical trials for pain relief. Here, we describe the identification of TrkA-specific inhibitors and the structural basis for their selectivity over other Trk family kinases...
December 30, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28038321/barriers-beliefs-and-practice-patterns-for-breast-cancer-reconstruction-a-provincial-survey
#17
Christopher J Coroneos, Karina Roth-Albin, Ajit S Rai, Amrit S Rai, Sophocles H Voineskos, Melissa C Brouwers, Ronen Avram, Barbara Heller
BACKGROUND: The purpose of this study was to characterize beliefs and practice patterns for breast cancer reconstruction among physicians who treat patients with breast cancer, in order to delineate current clinical practice. This survey was administered prior to Cancer Care Ontario guideline publication. METHOD: Survey questions addressed four domains: survival, delayed or obscured recurrence detection, delayed adjuvant therapy, and aesthetics. The survey was administered to 1160 Ontario plastic and general surgeons and radiation and medical oncologists...
December 27, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28033541/rhodamine-b-conjugates-of-triterpenoic-acids-are-cytotoxic-mitocans-even-at-nanomolar-concentrations
#18
Sven Sommerwerk, Lucie Heller, Christoph Kerzig, Annemarie E Kramell, René Csuk
Triterpenoic acids 1-6 exhibited very low or no cytotoxicity at all, but their corresponding 2,3-di-O-acetyl-piperazinyl amides 13-18 showed low EC50 values for several human tumor cell lines. Their cytotoxicity, however, was also high for the non-malignant mouse fibroblasts NIH 3T3. A significant improvement was achieved by preparing the rhodamine B derivatives 19-24. While rhodamine B is not cytotoxic (up to a concentration of 30μM - cut-off of the assay), the triterpenoid piperazine-spacered rhodamine B derivatives were cytotoxic in nano-molar concentration...
December 23, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28032747/a-programmable-dna-double-write-material-synergy-of-photolithography-and-self-assembly-nanofabrication
#19
Youngjun Song, Tsukasa Takahashi, Sejung Kim, Yvonne C Heaney, John Warner, Shaochen Chen, Michael J Heller
We demonstrate a DNA double-write process that uses UV to pattern a uniquely designed DNA write material, which produces two distinct binding identities for hybridizing two different complementary DNA sequences. The process requires no modification to the DNA by chemical reagents and allows programmed DNA self-assembly and further UV patterning in the UV exposed and nonexposed areas. Multilayered DNA patterning with hybridization of fluorescently labeled complementary DNA sequences, biotin probe/fluorescent streptavidin complexes, and DNA patterns with 500 nm line widths were all demonstrated...
December 29, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28032520/differential-expression-of-sdf-1-receptor-cxcr4-in-molecularly-defined-forms-of-inherited-thrombocytopenias
#20
Juan P Salim, Ana C Glembotsky, Paola R Lev, Cecilia P Marin Oyarzún, Nora P Goette, Felisa C Molinas, Rosana F Marta, Paula G Heller
The SDF-1-CXCR4 axis plays an essential role in the regulation of platelet production, by directing megakaryocyte (MK) migration toward the vascular niche, thus allowing terminal maturation and proplatelet formation, and also regulates platelet function in an autocrine manner. Inherited thrombocytopenias (IT) comprise a spectrum of diverse clinical conditions caused by mutations in genes involved in platelet production and function. We assessed CXCR4 expression and SDF-1 levels in a panel of well-characterized forms of IT...
December 29, 2016: Platelets
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