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https://www.readbyqxmd.com/read/28944811/determining-the-composition-of-the-vacuum-liquid-interface-in-ionic-liquid-mixtures
#1
E J Smoll, M A Tesa-Serrate, S M Purcell, L D'Andrea, D W Bruce, J M Slattery, M L Costen, T K Minton, K G McKendrick
The vacuum-liquid interfaces of a number of ionic-liquid mixtures have been investigated using the combination of reactive-atom scattering with laser-induced fluorescence detection (RAS-LIF), selected surface tension measurements, and molecular dynamics (MD) simulations. The mixtures are based on the widespread 1-alkyl-3-methylimidazolium ([Cnmim](+)) cation, including mixed cations which differ in chain length or chemical functionality with a common anion; and different anions for a common cation. RAS-LIF results imply that the surface compositions exhibit a general form of non-stoichiometric behaviour that mimics the well-known Henry's and Raoult's laws at low and high mole fraction, respectively...
September 25, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28938643/serum-peptidome-profiling-for-the-diagnosis-of-colorectal-cancer-discovery-and-validation-in-two-independent-cohorts
#2
Hao Wang, Chenghua Luo, Shengtao Zhu, Honghong Fang, Qing Gao, Siqi Ge, Haixia Qu, Qingwei Ma, Hongwei Ren, Youxin Wang, Wei Wang
Colorectal cancer (CRC) is one of the most common malignant neoplasms worldwide. Except for the existing fecal occult blood test, colonoscopy and sigmoidoscopy, no widely accepted in vitro diagnostic methods have been available. To identify potential peptide biomarkers for CRC, serum samples from a discovery cohort (100 CRC patients and 100 healthy controls) and an independent validation cohort (91 CRC patients and 91 healthy controls) were collected. Peptides were fractionated by weak cation exchange magnetic beads (MB-WCX) and analysed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28922374/fractional-laser-exposure-induces-neutrophil-infiltration-n1-phenotype-into-the-tumor-and-stimulates-systemic-anti-tumor-immune-response
#3
Masayoshi Kawakubo, Shadmehr Demehri, Dieter Manstein
BACKGROUND: Ablative fractional photothermolysis (aFP) using a CO2 laser generates multiple small diameter tissue lesions within the irradiation field. aFP is commonly used for a wide variety of dermatological indications, including treatment of photodamaged skin and dyschromia, drug delivery and modification of scars due to acne, surgical procedures and burns. In this study we explore the utility of aFP for treating oncological indications, including induction of local tumor regression and inducing anti-tumor immunity, which is in marked contrast to current indications of aFP...
2017: PloS One
https://www.readbyqxmd.com/read/28919557/synergistic-effects-of-dendritic-cell-targeting-and-laser-microporation-on-enhancing-epicutaneous-skin-vaccination-efficacy
#4
Yoan Machado, Sanne Duinkerken, Veronika Hoepflinger, Melissa Mayr, Evgeniia Korotchenko, Almedina Kurtaj, Isabel Pablos, Markus Steiner, Angelika Stoecklinger, Joyce Lübbers, Maximillian Schmid, Uwe Ritter, Sandra Scheiblhofer, Michael Ablinger, Verena Wally, Sarah Hochmann, Anna M Raninger, Dirk Strunk, Yvette van Kooyk, Josef Thalhamer, Richard Weiss
Due to its unique immunological properties, the skin is an attractive target tissue for allergen-specific immunotherapy. In our current work, we combined a dendritic cell targeting approach with epicutaneous immunization using an ablative fractional laser to generate defined micropores in the upper layers of the skin. By coupling the major birch pollen allergen Bet v 1 to mannan from S. cerevisiae via mild periodate oxidation we generated hypoallergenic Bet-mannan neoglycoconjugates, which efficiently targeted CD14+ dendritic cells and Langerhans cells in human skin explants...
September 14, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28915288/successful-treatment-of-keloid-with-fractionated-carbon-dioxide-co2-laser-and-laser-assisted-drug-delivery-of-triamcinolone-acetonide-ointment-in-an-african-american-man
#5
Ekaterina Kraeva, Derek Ho, Jared Jagdeo
Keloids are fibrous growths that occur as a result of abnormal response to dermal injury. Keloids are cosmetically disfiguring and may impair function, often resulting in decreased patient quality-of-life. Treatment of keloids remains challenging, and rate of recurrence is high. We present a case of a 39-year-old African-American man (Fitzpatrick VI) with a 10-year history of keloid, who was successfully treated with eight sessions of fractionated carbon dioxide (CO2) laser immediately followed by laser-assisted drug delivery (LADD) of topical triamcinolone acetonide (TAC) ointment and review the medical literature on fractionated CO2 laser treatment of keloids...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28912936/combination-of-q-switched-nd-yag-and-fractional-erbium-yag-lasers-in-treatment-of-melasma-a-randomized-controlled-clinical-trial
#6
Shiva Alavi, Ehsan Abolhasani, Sharin Asadi, Mohammadali Nilforoushzadeh
Introduction: Ablative and nonablative lasers have been used to treat melasma. We aimed to assess and compare the combining Q-switched Nd:YAG laser (QSNYL) and fractional erbium:YAG laser (FEYL) with QSNYL alone in treatment of melasma. Methods: This randomized controlled clinical trial was performed in our Research Center during 2013-2014. Women with melasma and without a history of keloid formation, hypersensitivity to hydroquinone, or pigmentary changes due to laser therapy were randomly allocated to receive four sessions of either QSNYL-FEYL combination or QSNYL alone...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/28912721/physical-and-chemical-processes-and-the-morphofunctional-characteristics-of-human-erythrocytes-in-hyperglycaemia
#7
Victor V Revin, Natalia A Klenova, Natalia V Gromova, Igor P Grunyushkin, Ilia N Solomadin, Alexander Y Tychkov, Anastasia A Pestryakova, Anna V Sadykhova, Elvira S Revina, Ksenia V Prosnikova, Jean-Christophe Bourdon, Nikolai Zhelev
Background: This study examines the effect of graduated hyperglycaemia on the state and oxygen-binding ability of hemoglobin, the correlation of phospholipid fractions and their metabolites in the membrane, the activity of proteolytic enzymes and the morphofunctional state of erythrocytes. Methods: Conformational changes in the molecule of hemoglobin were determined by Raman spectroscopy. The structure of the erythrocytes was analyzed using laser interference microscopy (LIM). To determine the activity of NADN-methemoglobinreductase, we used the P...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28903553/monitoring-microbial-mineralization-using-reverse-stable-isotope-labelling-analysis-by-mid-infrared-laser-spectroscopy
#8
Xiyang Dong, Maik A Jochmann, Martin Elsner, Armin H Meyer, Leonard E Bäcker, Mona Rahmatullah, Daniel Schunk, Guido Lens, Rainer Udo Meckenstock
Assessing the biodegradation of organic compounds is a frequent question in environmental science. Here, we present a sensitive, inexpensive, and simple approach to monitor microbial mineralization using reverse stable isotope labelling analysis (RIL) of dissolved inorganic carbon (DIC). The medium for the biodegradation assay contains regular organic compounds and (13)C-labelled DIC with (13)C atom fractions (x((13)C)DIC) higher than natural abundance (typically 2-50%). The produced CO2 (x((13)C) ≈ 1.11%) gradually dilutes the initial x((13)C)DIC allowing to quantify microbial mineralization using mass-balance calculations...
September 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28902036/clinical-and-histological-evaluations-of-enlarged-facial-skin-pores-after-low-energy-level-treatments-with-fractional-carbon-dioxide-laser-in-korean-patients
#9
Hyuck Hoon Kwon, Sun Chul Choi, Won-Yong Lee, Jae Yoon Jung, Gyeong-Hun Park
BACKGROUND: Enlarged facial pores can be an early manifestation of skin aging and they are a common aesthetic concern for Asians. However, studies of improving the appearance of enlarged pores have been limited. OBJECTIVE: The authors aimed to study the application of CO2 fractional laser treatment in patients with enlarged facial pores. METHODS: A total of 32 patients with dilated facial pores completed 3 consecutive sessions of low energy level treatments with a fractional CO2 laser at 4-week intervals...
September 4, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28899809/estimation-of-drug-particle-size-in-intact-tablets-by-two-dimensional-x-ray-diffractometry
#10
Seema Thakral, Naveen K Thakral, Raj Suryanarayanan
The average grain size of a crystalline material can be determined from the γ-profile of Debye rings in two-dimensional X-ray diffraction (2D XRD) frames. Our objectives were to: (i) validate the method for organic powders and use it to determine the grain size in intact tablets, and (ii) demonstrate the pharmaceutical application of this technique by determining the grain size of the active pharmaceutical ingredient (API) in marketed formulations. Six sieve fractions of sucrose were prepared and the particle size distribution was confirmed by laser diffraction...
September 9, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28895756/early-treatment-using-fractional-co2-laser-before-skin-suture-during-scar-revision-surgery-in-asians
#11
Feiya Du, Yusheng Yu, Zhiqin Zhou, Liujia Wang, Shusen Zheng
Fractional CO2 laser is one of the most effective treatment options used to resurface scars; However, most previous studies have been performed on mature scars at least 2 months after surgery. Recent studies have emphasized the importance of early treatment to reduce scar formation. In the present study, we described our experience with fractional CO2 laser intervention before skin suture during scar revision surgery in Asians, and found the treatment was safe and effective.
September 12, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28894992/fractional-carbon-dioxide-laser-for-the-treatment-of-facial-atrophic-acne-scars-prospective-clinical-trial-with-short-and-long-term-evaluation
#12
Gonca Elcin, Basak Yalici-Armagan
The aim of this study was to evaluate the efficacy and safety of fractional carbon dioxide laser for the treatment of acne scars. Thirty-one participants, 15 female and 16 male, whose mean age was 34.84 ± 10.94 years, were included in this prospective study. The study took place between 2012 and 2016. Participants were evaluated with the "ECCA Grading Scale" before the first session, 3 months (short-term evaluation) and 3 years after the last session (long-term evaluation). Participants received two or three treatment sessions at 4-week intervals, with a 10,600 nm fractional carbon dioxide laser with pulse energies ranging between 100 and 160 mJ, 120 spot type, 75-100 spot/cm(2) density, and 30 W power...
September 11, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28894392/fractional-co2-laser-treatment-for-vulvovaginal-atrophy-symptoms-and-vaginal-rejuvenation-in-perimenopausal-women
#13
César Arroyo
BACKGROUND: This study investigated a novel fractional carbon dioxide (CO2) laser for treatment of symptoms associated with vulvovaginal atrophy (VVA) in perimenopausal women. METHODS: The study included 21 perimenopausal women (mean age 45±7 years) treated three times by CO2 laser resurfacing and coagulation of the vaginal canal tissue and mucosal tissue of the introitus. Vaginal health index (VHI) scores were computed by the investigator at baseline and follow-ups...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28891191/molecular-characterization-of-branched-polysaccharides-from-tremella-fuciformis-by-asymmetrical-flow-field-flow-fractionation-and-size-exclusion-chromatography
#14
Ding-Tao Wu, Yong Deng, Jing Zhao, Shao-Ping Li
To accurately characterize branched polysaccharides with high molecular weights from medicinal and edible mushrooms and identify the limitations of size exclusion chromatography, molecular characteristics of polysaccharides from Tremella fuciformis were determined and compared by asymmetrical flow field-flow fractionation coupled with multi-angle laser light scattering and refractive index detection, and size exclusion chromatography coupled with multi-angle laser light scattering and refractive index detection, respectively...
September 11, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28887223/efficacy-of-erythrosine-and-cyanidin-3-glucoside-mediated-photodynamic-therapy-on-porphyromonas-gingivalis-biofilms-using-green-light-laser
#15
Aroon Teerakapong, Teerasak Damrongrungruang, Sajee Sattayut, Noppawan Phumala Morales, Surada Tantananugool
BACKGROUND: The purpose of this in vitro study was to evaluate the efficacy of erythrosine and cyanidin-3-glucoside as photosensitizers in PDT for the elimination of Porphyromonas gingivalis (P. gingivalis) biofilms. METHODS: P. gingivalis biofilms were prepared from a chronic periodontitis subject. Erythrosine and cyanidin-3-glucoside were prepared and randomly allocated as follows: 110, 220, 330, and 440μM erythrosine; 101, 202, 303, and 404μM anthocyanin; and 440μM erythrosine+404μM cyanidin-3-glucoside...
September 5, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28881431/fractional-co2-laser-of-the-vagina-for-genitourinary-syndrome-of-menopause-is-the-out-of-pocket-cost-worth-the-outcome-of-treatment
#16
Patrick Lang, Jeffrey R Dell, Leonard Rosen, Peter Weiss, Mickey Karram
OBJECTIVES: The purpose of this study is to assess patient's satisfaction treatment outcomes and out-of-pocket expense for the fractional CO2 laser (SmartXide) in the treatment of genitourinary symptoms of menopause (GSM). MATERIALS AND METHODS: A multicenter retrospective cohort study of patients who completed a course of three vaginal treatments with the SmartXide(11) Fractional CO2 laser. Patients contacted via telephone and asked to participate in questionnaires to evaluate for adverse outcomes since last treatment, symptom severity before and after treatment, patient satisfaction with treatment, patient satisfaction with out-of-pocket expense, and sexual function...
September 7, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28880868/towards-assessing-cortical-bone-porosity-using-low-frequency-quantitative-acoustics-a-phantom-based-study
#17
Florian Vogl, Benjamin Bernet, Daniele Bolognesi, William R Taylor
PURPOSE: Cortical porosity is a key characteristic governing the structural properties and mechanical behaviour of bone, and its quantification is therefore critical for understanding and monitoring the development of various bone pathologies such as osteoporosis. Axial transmission quantitative acoustics has shown to be a promising technique for assessing bone health in a fast, non-invasive, and radiation-free manner. One major hurdle in bringing this approach to clinical application is the entanglement of the effects of individual characteristics (e...
2017: PloS One
https://www.readbyqxmd.com/read/28869630/deposition-of-phosphate-coatings-on-titanium-within-scaffold-structure
#18
Bartłomiej Trybuś, Andrzej Zieliński, Rene Beutner, Tomasz Seramak, Dieter Scharnweber
PURPOSE: Existing knowledge about the appearance, thickness, and chemical composition of phosphate coatings on titanium inside porous structures is insufficient. Such knowledge is important for the design and fabrication of porous implants. METHODS: Metallic scaffolds were fabricated by selective laser melting of 316L stainless steel powder. Phosphate coatings were deposited on Ti sensors placed either outside the scaffolds or in the holes in the scaffolds. The electrochemically-assisted cathodic deposition of phosphate coatings was performed under galvanostatic conditions in an electrolyte containing the calcium and phosphate ions...
2017: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/28866727/long-term-reliability-of-fractioned-co2-laser-as-a-treatment-for-vulvovaginal-atrophy-vva-symptoms
#19
Annalisa Pieralli, Claudia Bianchi, Manuela Longinotti, Serena Corioni, Noemi Auzzi, Angelamaria Becorpi, Maria Grazia Fallani, Giuseppe Cariti, Felice Petraglia
PURPOSE: The aim of this study was to evaluate long-term effects of the fractional CO2 laser for the treatment of vulvovaginal atrophy (VVA) symptoms. METHODS: Women presenting with VVA symptoms and meeting inclusion criterion were enrolled to fractioned CO2 laser therapy. Patient's satisfaction was measured on five-point Likert scale at 4 weeks and 6, 12, 18, 24 months after treatment by interview and clinical examination for vaginal livability. RESULTS: 184 patients constituted the final study group: 128 women were spontaneous menopause and 56 were oncological menopause...
September 2, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28866449/fractional-flow-reserve-in-below-the-knee-arteries-with-critical-limb-ischemia-and-validation-against-gold-standard-morphologic-functional-measures-and-long-term-clinical-outcomes
#20
Zoltán Ruzsa, Szilárd Róna, Gábor G Tóth, Péter Sótonyi, Olivier F Bertrand, Balázs Nemes, Béla Merkely, Kálmán Hüttl
INTRODUCTION: The aim of this study was to assess the applicability of fractional flow reserve measurement (FFR) in below-the-knee (BTK) arteries and to evaluate its correlation with non-invasive functional parameters before and after angioplasty. METHODS: We enrolled 39 patients with severe BTK arterial lesions. Inclusion criteria were critical limb ischemia (Rutherford 4-6) and angiographically proven arterial stenosis of the distal lower limb (percent diameter stenosis ≥70%)...
July 18, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
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