keyword
https://read.qxmd.com/read/38538641/in-major-dysmood-disorder-physiosomatic-chronic-fatigue-and-fibromyalgia-symptoms-are-driven-by-immune-activation-and-increased-immune-associated-neurotoxicity
#21
JOURNAL ARTICLE
Michael Maes, Abbas F Almulla, Bo Zhou, Ali Abbas Abo Algon, Pimpayao Sodsai
Major depressive disorder (MDD) is accompanied by activated neuro-immune pathways, increased physiosomatic and chronic fatigue-fibromyalgia (FF) symptoms. The most severe MDD phenotype, namely major dysmood disorder (MDMD), is associated with adverse childhood experiences (ACEs) and negative life events (NLEs) which induce cytokines/chemokines/growth factors. To delineate the impact of ACE + NLEs on physiosomatic and FF symptoms in first episode (FE)-MDMD, and examine whether these effects are mediated by immune profiles...
March 28, 2024: Scientific Reports
https://read.qxmd.com/read/38538070/lentinan-inhibits-cell-invasion-via-m2-polarization-of-tumor-associated-macrophages-and-wnt-%C3%AE-catenin-signaling-in-non-small-cell-lung-cancer
#22
JOURNAL ARTICLE
Yan Yang, Yue Cheng, Yanfei Mu, Xianjun Tang, Xiaosong Mu
Non-small cell lung cancer (NSCLC) is an aggressive and devastating cancer due to its metastasis induced by increased invasion. Lentinan is a polysaccharide exerting antitumor roles in multiple cancers, including lung cancer. However, the influence of lentinan on cell invasion in NSCLC remains unclear. Cell invasion was detected by transwell analysis. Matrix metallopeptidase 9 (MMP9) levels were measured through immunofluorescence staining. The markers arginase-1 (Arg-1), CD206 and interleukin (IL)-10 (IL-10) of M2 macrophages, Wnt3a, and β-catenin levels were measured by western blot or enzyme linked immunosorbent assay...
March 2024: Chemical Biology & Drug Design
https://read.qxmd.com/read/38537405/unmasking-the-dynamics-of-mycoplasma-gallisepticum-deciphering-hd11-macrophage-polarization-for-innovative-infection-control-strategies
#23
JOURNAL ARTICLE
Tengfei Wang, Wenqing Zhao, Zhenping Qi, Shan Lv, Yufei Xiao, Yingjie Wang, Qiao Guo, Lulu Wang, Xiuli Peng
Mycoplasma gallisepticum (MG) is a highly contagious avian respiratory pathogen characterized by rapid spread, widespread distribution, and long-term persistence of infection. Previous studies have shown that chicken macrophage HD11 cells play a critical role in the replication and immunomodulation of MG. Macrophages are multifunctional immunomodulatory cells that polarize into different functions and morphologies in response to exogenous stimuli. However, the effect of MG infection on HD11 polarization is not well understood...
March 13, 2024: Poultry Science
https://read.qxmd.com/read/38536578/the-role-of-macrophages-in-lung-fibrosis-and-the-signaling-pathway
#24
REVIEW
Xingmei Wang, Jiaxu Zhou, Xinrui Li, Chang Liu, Lan Liu, Hong Cui
Lung fibrosis is a dysregulated repair process caused by excessive deposition of extracellular matrix that can severely affect respiratory function. Macrophages are a group of immune cells that have multiple functions and can perform a variety of roles. Lung fibrosis develops with the involvement of pro-inflammatory and pro-fibrotic factors secreted by macrophages. The balance between M1 and M2 macrophages has been proposed to play a role in determining the trend and severity of lung fibrosis. New avenues and concepts for preventing and treating lung fibrosis have emerged in recent years through research on mitochondria, Gab proteins, and exosomes...
March 27, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38536567/mir-374a-b-5p-suppresses-cell-growth-in-papillary-thyroid-carcinoma-through-blocking-exosomal-anxa1-induced-macrophage-m2-polarization
#25
JOURNAL ARTICLE
Sanbao Liu
Papillary thyroid carcinoma (PTC), comprising 85% of all thyroid cancers, is an epithelial malignancy. The potential for malignant transformation in normal cells by thyroid cancer cells via exosomal Annexin A1 (ANXA1) delivery is investigated in this study. Our aim is to determine the impact of PTC cells on macrophage polarization through exosomal ANXA1 secretion and its implications for tumor progression. Exosomes in PTC cells were examined using transmission electron microscopy, exosome labeling, and nanoparticle tracking analysis...
March 27, 2024: Biochemical Genetics
https://read.qxmd.com/read/38536097/macrophage-polarization-dynamics-in-biomaterials-implications-for-in-vitro-wound-healing
#26
JOURNAL ARTICLE
Pravin Shankar Giri, Subha Narayan Rath
The interaction between biomaterials and the immune system plays a pivotal role in determining the success or failure of implantable devices. Macrophages, as key orchestrators of immune responses, exhibit diverse reactions that influence tissue integration or lead to implant failure. This study focuses on unraveling the intricate relationship between macrophage phenotypes and biomaterials, specifically hydrogels, by employing THP-1 cells as a model. Through a comprehensive investigation using polysaccharide, polymer, and protein-based hydrogels, our research sheds light on how the properties of hydrogels influence macrophage polarization...
March 27, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38535999/m1-intestinal-macrophages-derived-exosomes-promote-colitis-progression-and-mucosal-barrier-injury
#27
JOURNAL ARTICLE
Rui Du, Sihan Chen, Chenyang Han, Zhongmei He, Hongyan Pei, Yang Yang
AIM: This work aimed to investigate the role of M1 intestinal macrophages-derived exosomes (M1-Exo) in colitis and its mechanism. METHODS: M1 polarization of intestinal macrophages was induced in vitro , and their exosomes were extracted and identified. Thereafter, the DSS-induced colitis mouse model was built. Each mouse was given intraperitoneal injection of exosomes, and then mouse weight and DAI were dynamically monitored. In addition, the levels of cytokines were detected by ELISA...
March 26, 2024: Aging
https://read.qxmd.com/read/38535472/anti-inflammatory-activity-of-cyanobacteria-pigment-extracts-physiological-free-radical-scavenging-and-modulation-of-inos-and-lox-activity
#28
JOURNAL ARTICLE
Lécia Rodrigues, Janaína Morone, Guilherme Scotta Hentschke, Vitor Vasconcelos, Graciliana Lopes
Cyanobacteria are among the oldest organisms colonizing Earth. Their great biodiversity and ability to biosynthesize secondary metabolites through a variety of routes makes them attractive resources for biotechnological applications and drug discovery. In this pioneer study, four filamentous cyanobacteria ( Cephalothrix lacustris LEGE 15493, Leptolyngbya boryana LEGE 15486, Nodosilinea nodulosa LEGE 06104 and Leptothoe sp. LEGE 11479) were explored for their anti-inflammatory potential in cell and cell-free in vitro bioassays, involving different inflammatory mediators and enzymes...
March 12, 2024: Marine Drugs
https://read.qxmd.com/read/38535449/the-role-of-sargahydroquinoic-acid-and-sargachromenol-in-the-anti-inflammatory-effect-of-sargassum-yezoense
#29
JOURNAL ARTICLE
Yena Park, Lei Cao, Suhyeon Baek, Seungjin Jeong, Hyun Jung Yun, Mi-Bo Kim, Sang Gil Lee
The anti-inflammatory effect of the ethanol extract of Sargassum yezoense and its fractions were investigated in this study. The ethanol extract exhibited a strong anti-inflammatory effect on lipopolysaccharide-stimulated RAW 264.7 macrophages and effectively suppressed the M1 polarization of murine bone-marrow-derived macrophages stimulated by lipopolysaccharides and IFN-γ (interferon-gamma). Through a liquid-liquid extraction process, five fractions (n-hexane, chloroform, ethyl acetate, butanol, and aqueous) were acquired...
February 26, 2024: Marine Drugs
https://read.qxmd.com/read/38533720/tumor-associated-macrophages-as-key-contributors-and-targets-in-current-and-future-therapies-for-melanoma
#30
REVIEW
Shabana Habib, Gabriel Osborn, Zena Willsmore, Min Waye Chew, Sophie Jakubow, Amanda Fitzpatrick, Yin Wu, Khushboo Sinha, Hawys Lloyd-Hughes, Jenny L C Geh, Alastair D MacKenzie-Ross, Sean Whittaker, Victoria Sanz-Moreno, Katie E Lacy, Sophia N Karagiannis, Rebecca Adams
INTRODUCTION: Despite the success of immunotherapies for melanoma in recent years, there remains a significant proportion of patients who do not yet derive benefit from available treatments. Immunotherapies currently licensed for clinical use target the adaptive immune system, focussing on Tcell interactions and functions. However, the most prevalent immune cells within the tumor microenvironment (TME) of melanoma are macrophages, a diverse immune cell subset displaying high plasticity, to which no current therapies are yet directly targeted...
March 27, 2024: Expert Review of Clinical Immunology
https://read.qxmd.com/read/38533538/cxcr4-targeted-macrophage-derived-biomimetic-hybrid-vesicle-nanoplatform-for-enhanced-cancer-therapy-through-codelivery-of-manganese-and-doxorubicin
#31
JOURNAL ARTICLE
Yeonwoo Jang, Young Seok Cho, April Kim, Xingwu Zhou, Yujin Kim, Ziye Wan, James J Moon, Hansoo Park
Immune-cell-derived membranes have garnered significant attention as innovative delivery modalities in cancer immunotherapy for their intrinsic immune-modulating functionalities and superior biocompatibilities. Integrating additional parental cell membranes or synthetic lipid vesicles into cellular vesicles can further potentiate their capacities to perform combinatorial pharmacological activities in activating antitumor immunity, thus providing insights into the potential of hybrid cellular vesicles as versatile delivery vehicles for cancer immunotherapy...
March 27, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38532231/determination-of-m1-m2-macrophage-polarization-in-ipsilateral-and-contralateral-rat-testis-tissue-following-unilateral-torsion-detorsion
#32
JOURNAL ARTICLE
Merve Kavak Balgetir, Nalan Kaya Tektemur, Ahmet Tektemur, Gaffari Türk, İbrahim Halil Güngör, Aslıhan Cakir Cihangiroglu, Ramazan Fazıl Akkoç, Tuncay Kuloglu, Durrin Ozlem Dabak
The present study investigates the changes in M1/M2 macrophage polarization resulting from unilateral testicular torsion in the bilateral testis. The study sample included 63 male Sprague-Dawley rats, which were randomly divided into nine groups (n = 7): Control, Sham (4 h (4 h), 24 h, 7 days (7d), 14d), and Torsion/Detorsion (T/D) (4 h, 24 h, 7d, 14d). Histopathological evaluations revealed no changes in the Sham groups, while T/D was noted to cause edema, vascular occlusion, disruption of seminiferous tubule epithelial organization, germ cell abnormalities and structural anomalies in the experimental rats, the severity and extent of which increased from 4 h to 14d after T/D...
March 26, 2024: Reproductive Sciences
https://read.qxmd.com/read/38531346/bioactive-nanofiber-hydrogel-composite-regulates-regenerative-microenvironment-for-skeletal-muscle-regeneration-after-volumetric-muscle-loss
#33
JOURNAL ARTICLE
Wei Yu, Xiangqi Zhang, Muge Gu, Jiayu Wang, Yihui Zhang, Wenkai Zhang, Wei-En Yuan
Volumetric muscle loss (VML) is a severe form of muscle trauma that exceeds the regenerative capacity of skeletal muscle tissue, leading to substantial functional impairment. The abnormal immune response and excessive reactive oxygen species (ROS) accumulation hinder muscle regeneration following VML. Here, we engineered an interfacial cross-linked hydrogel-poly(ε-caprolactone) nanofiber composite that incorporates both biophysical and biochemical cues to modulate the immune and ROS microenvironment for enhanced VML repair...
March 26, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38531306/pooled-crispr-screening-of-high-content-cellular-phenotypes-using-ghost-cytometry
#34
JOURNAL ARTICLE
Asako Tsubouchi, Yuri An, Yoko Kawamura, Yuichi Yanagihashi, Hirofumi Nakayama, Yuri Murata, Kazuki Teranishi, Soh Ishiguro, Hiroyuki Aburatani, Nozomu Yachie, Sadao Ota
Recent advancements in image-based pooled CRISPR screening have facilitated the mapping of diverse genotype-phenotype associations within mammalian cells. However, the rapid enrichment of cells based on morphological information continues to pose a challenge, constraining the capacity for large-scale gene perturbation screening across diverse high-content cellular phenotypes. In this study, we demonstrate the applicability of multimodal ghost cytometry-based cell sorting, including both fluorescent and label-free high-content phenotypes, for rapid pooled CRISPR screening within vast cell populations...
March 25, 2024: Cell Rep Methods
https://read.qxmd.com/read/38531198/mammary-tissue-derived-extracellular-matrix-hydrogels-reveal-the-role-of-irradiation-in-driving-a-pro-tumor-and-immunosuppressive-microenvironment
#35
JOURNAL ARTICLE
Tian Zhu, Steven M Alves, Arianna Adamo, Xiaona Wen, Kevin C Corn, Anastasia Shostak, Shereena Johnson, Nicholas D Shaub, Shannon E Martello, Benjamin C Hacker, Antonio D'Amore, Rizia Bardhan, Marjan Rafat
Radiation therapy (RT) is essential for triple negative breast cancer (TNBC) treatment. However, patients with TNBC continue to experience recurrence after RT. The role of the extracellular matrix (ECM) of irradiated breast tissue in tumor recurrence is still unknown. In this study, we evaluated the structure, molecular composition, and mechanical properties of irradiated murine mammary fat pads (MFPs) and developed ECM hydrogels from decellularized tissues (dECM) to assess the effects of RT-induced ECM changes on breast cancer cell behavior...
March 21, 2024: Biomaterials
https://read.qxmd.com/read/38530976/exosomes-derived-from-caerulein-stimulated-pancreatic-acinar-cells-mediate-peritoneal-macrophage-m1-polarization-and-pyroptosis-via-an-mir-24-3p-march3-nlrp3-axis-in-acute-pancreatitis
#36
JOURNAL ARTICLE
Xiao-Ju Su, Yan Chen, Qi-Chen Zhang, Xiao-Bo Peng, Ya-Ping Liu, Lei Wang, Yi-Qi Du
OBJECTIVES: Acute pancreatitis (AP) has a high incidence of hospitalizations, morbidity, and mortality worldwide. A growing number of studies on AP pathogenesis are based on caerulein-induced experimental model, which simulates human AP in vivo. It has been demonstrated that both pancreatic acinar cells and peritoneal macrophages are involved in pancreatic inflammation and damage. However, their connection has not been well understood. METHODS: A caerulein-induced AP model was established on the pancreatic acinar cell line AR42J...
March 27, 2024: Pancreas
https://read.qxmd.com/read/38530777/metformin-boosts-anti-tumor-immunity-and-improves-prognosis-in-upfront-resected-pancreatic-cancer-an-observational-study
#37
JOURNAL ARTICLE
Casper W F van Eijck, Disha Vadgama, Casper H J van Eijck, Johanna W Wilmink
BACKGROUND: Beyond demographic and immune factors, metabolic considerations, particularly metformin's recognized impact in oncology, warrant exploration in treating pancreatic cancer. This study aimed to investigate the influence of metformin on patient survival and its potential correlation with distinct immune profiles in PDAC tumors. METHODS: We included 82 upfront resected and 66 gemcitabine-based neoadjuvant chemoradiotherapy (nCRT)-treated patients from the PREOPANC randomized controlled trial (RCT)...
March 26, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38530238/the-human-mif-polymorphism-catt-7-enhances-pro-inflammatory-macrophage-polarization-in-a-clinically-relevant-model-of-allergic-airway-inflammation
#38
JOURNAL ARTICLE
Hazel Dunbar, Ian J Hawthorne, Eóin N McNamee, Michelle E Armstrong, Seamas C Donnelly, Karen English
High level expression of the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) has been associated with severe asthma. The role of MIF and its functional promotor polymorphism in innate immune training is currently unknown. Using novel humanized CATT7 MIF mice, this study is the first to investigate the effect of MIF on bone marrow-derived macrophage (BMDM) memory after house dust mite (HDM) challenge. CATT7 BMDMs demonstrated a significant primed increase in M1 markers following HDM and LPS stimulation, compared to naive mice...
March 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38528656/altered-placental-immune-cell-composition-and-gene-expression-with-isolated-fetal-spina-bifida
#39
JOURNAL ARTICLE
Marina White, Hasan Abdo, David Grynspan, Tim Van Mieghem, Kristin L Connor
PROBLEM: Fetal spina bifida (SB) is more common in pregnant people with folate deficiency or anomalies of folate metabolism. It is also known that fetuses with SB have a higher risk of low birthweight, a condition that is typically placental-mediated. We therefore hypothesized that fetal SB would associate with altered expression of key placental folate transporters and an increase in Hofbauer cells (HBCs), which are folate-dependent placental macrophages. METHOD OF STUDY: Folate receptor-α (FRα), proton coupled folate receptor (PCFT), and reduced folate carrier (RFC) protein localization and expression (immunohistochemistry) and HBC phenotypes (HBC abundance and folate receptor-β [FRβ] expression; RNA in situ hybridization) were assessed in placentae from fetuses with SB (cases; n = 12) and in term (n = 10) and gestational age (GA) - and maternal body mass index - matched (n = 12) controls without congenital anomalies...
March 2024: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/38526969/electroacupuncture-promotes-macrophage-microglial-m2-polarization-and-suppresses-inflammatory-pain-through-ampk
#40
JOURNAL ARTICLE
Fu-Bei Nan, Yi-Xiao Gu, Jun-Lu Wang, Shuang-Dong Chen
Inflammatory pain, the most prevalent disease globally, remains challenging to manage. Electroacupuncture emerges as an effective therapy, yet its underlying mechanisms are not fully understood. This study investigates whether adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK)-regulated silent information regulator 1 (SIRT1) contributes to electroacupuncture's antinociceptive effects by modulating macrophage/microglial polarization in the spinal dorsal horn of a mouse model of inflammatory pain...
March 20, 2024: Neuroreport
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