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macrophage polarization

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https://www.readbyqxmd.com/read/29690889/effect-of-colorectal-cancer-derived-extracellular-vesicles-on-the-immunophenotype-and-cytokine-secretion-profile-of-monocytes-and-macrophages
#1
Ineta Popēna, Artūrs Ābols, Līga Saulīte, Kārlis Pleiko, Elīna Zandberga, Kaspars Jēkabsons, Edgars Endzeliņš, Alicia Llorente, Aija Linē, Una Riekstiņa
BACKGROUND: Macrophages are one of the most important players in the tumor microenvironment. The polarization status of tumor associated macrophages into a pro-inflammatory type M1 or anti-inflammatory type M2 may influence cancer progression and patient survival. Extracellular vesicles (EVs) are membrane-bound vesicles containing different biomolecules that are involved in cell to cell signal transfer. Accumulating evidence suggests that cancer-derived EVs are taken up by macrophages and modulate their phenotype and cytokine profile...
April 24, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29689377/ambient-particulate-matter-activates-the-aryl-hydrocarbon-receptor-in-dendritic-cells-and-enhances-th17-polarization
#2
Alejandro R Castañeda, Kent E Pinkerton, Keith J Bein, Alfonso Magaña-Méndez, Houa T Yang, Paul Ashwood, Christoph F A Vogel
The objective of this study was to explore the role of the aryl hydrocarbon receptor (AhR) in ambient particulate matter (PM)-mediated activation of dendritic cells (DCs) and Th17-immune responses in vitro. To assess the potential role of the AhR in PM-mediated activation of DCs, co-stimulation, and cytokine expression, bone marrow (BM)-derived macrophages and DCs from C57BL6 wildtype or AhR knockout (AhR-/- ) mice were treated with PM. Th17 differentiation was assessed via co-cultures of wildtype or AhR-/- BMDCs with autologous naive T cells...
April 21, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29687414/m1-macrophages-but-not-m2-macrophages-are-characterized-by-upregulation-of-crp-expression-via-activation-of-nf%C3%AE%C2%BAb-a-possible-role-for-ox-ldl-in-macrophage-polarization
#3
Marielle Kaplan, Anna Shur, Yvgeny Tendler
Arterial macrophages comprise a heterogeneous population: pro-inflammatory (M1) and anti-inflammatory (M2). Since C-reactive protein (CRP) is produced by macrophages in atherosclerotic lesions, understanding of CRP regulation in macrophages could be crucial to decipher inflammatory patterns in atherogenesis. We aimed to analyze CRP expression in M1/M2 macrophages and to question whether it involves NFκB signaling pathway. Furthermore, we questioned whether oxidative stress affect macrophage phenotype and modulate macrophage CRP expression...
April 23, 2018: Inflammation
https://www.readbyqxmd.com/read/29686050/lysosomal-protein-lamtor1-controls-innate-immune-responses-via-nuclear-translocation-of-transcription-factor-eb
#4
Yoshitomo Hayama, Tetsuya Kimura, Yoshito Takeda, Shigeyuki Nada, Shohei Koyama, Hyota Takamatsu, Sujin Kang, Daisuke Ito, Yohei Maeda, Masayuki Nishide, Satoshi Nojima, Hana Sarashina-Kida, Takashi Hosokawa, Yuhei Kinehara, Yasuhiro Kato, Takeshi Nakatani, Yoshimitsu Nakanishi, Takeshi Tsuda, Taro Koba, Masato Okada, Atsushi Kumanogoh
Amino acid metabolism plays important roles in innate immune cells, including macrophages. Recently, we reported that a lysosomal adaptor protein, Lamtor1, which serves as the scaffold for amino acid-activated mechanistic target of rapamycin complex 1 (mTORC1), is critical for the polarization of M2 macrophages. However, little is known about how Lamtor1 affects the inflammatory responses that are triggered by the stimuli for TLRs. In this article, we show that Lamtor1 controls innate immune responses by regulating the phosphorylation and nuclear translocation of transcription factor EB (TFEB), which has been known as the master regulator for lysosome and autophagosome biogenesis...
April 23, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29684352/nrf2-activation-protects-against-intratracheal-lps-induced-mouse-murine-acute-respiratory-distress-syndrome-by-regulating-macrophage-polarization
#5
Juan Wei, Guannan Chen, Xuan Shi, Huanping Zhou, Meiyun Liu, Yuanli Chen, Di Feng, Pengcheng Zhang, Lingmin Wu, Xin Lv
The transcription factor nuclear factor E2-related factor 2 (Nrf2) is known to control the expression of antioxidant response elements and cytoprotective genes and modulate inflammatory response, helping to ameliorate damage in many diseases. Exactly how Nrf2 regulates innate inflammatory homeostasis remains unclear. In this study, we provide in vitro and in vivo evidence that Nrf2 plays a crucial role in macrophage polarization and acute respiratory distress syndrome (ARDS). We conducted in vitro experiments using a mouse alveolar macrophage cell line as well as primary cultures of macrophages in which cells were exposed to lipopolysaccharide (LPS) or interferon-γ in order to mimic ARDS, in the presence or absence of the Nrf2 activator tert-butylhydroquinone (tBHQ)...
April 20, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29683754/micrornas-in-idiopathic-pulmonary-fibrosis-new-research-progress-and-their-pathophysiological-implication
#6
Chenggui Miao, Youyi Xiong, Guoxue Zhang, Jun Chang
Many studies have shown that microRNAs (miRNAs) play important roles in the development of idiopathic pulmonary fibrosis (IPF). The purpose of this review is to systematically summarize the recent advance of miRNAs in the pathology of IPF, highlighting the new research progress and their pathophysiological implication. Recent studies have shown that miRNAs differentially expressed in blood and lung tissue from IPF patients are closely related to the occurrence of IPF disease, which may be IPF diagnostic markers and prognostic indicators...
April 23, 2018: Experimental Lung Research
https://www.readbyqxmd.com/read/29680681/hdac-inhibition-helps-post-mi-healing-by-modulating-macrophage-polarization
#7
Denise Kimbrough, Sabina H Wang, Lillianne H Wright, Santhosh K Mani, Harinath Kasiganesan, Mandy La Rue, Qi Cheng, Satish N Nadig, Carl Atkinson, Donald R Menick
AIMS: Following an acute myocardial infarction (MI) the extracellular matrix (ECM) undergoes remodeling in order to prevent dilation of the infarct area and maintain cardiac output. Excessive and prolonged inflammation following an MI exacerbates adverse ventricular remodeling. Macrophages are an integral part of the inflammatory response that contribute to this remodeling. Treatment with histone deacetylase (HDAC) inhibitors preserves LV function and myocardial remodeling in the post-MI heart...
April 19, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29677388/engulfment-of-hb-activated-platelets-differentiates-monocytes-into-pro-inflammatory-macrophages-in-pnh-patients
#8
Rashi Singhal, Sheetal Chawla, Harish Batra, Sameer Gupta, Amrita Ojha, Deepak K Rathore, Tulika Seth, Prasenjit Guchhait
The distinct response shown by different phenotypes of macrophages and monocytes under various clinical conditions have put the heterogeneity of these cells into focus of investigation for several diseases. Recently we have described that after engulfing Hb-activated platelets, classical monocytes differentiated into pro-inflammatory phenotypes, which were abundant in the circulation of PNH and SCD patients. Our current study shows that upon engulfment of Hb-activated platelets, monocytes differentiate into M1-macrophages under M1-polarization stimulus (GM-CSF, IFN-γ+LPS)...
April 20, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29674655/reduced-oxidative-capacity-in-macrophages-results-in-systemic-insulin-resistance
#9
Saet-Byel Jung, Min Jeong Choi, Dongryeol Ryu, Hyon-Seung Yi, Seong Eun Lee, Joon Young Chang, Hyo Kyun Chung, Yong Kyung Kim, Seul Gi Kang, Ju Hee Lee, Koon Soon Kim, Hyun Jin Kim, Cuk-Seong Kim, Chul-Ho Lee, Robert W Williams, Hail Kim, Heung Kyu Lee, Johan Auwerx, Minho Shong
Oxidative functions of adipose tissue macrophages control the polarization of M1-like and M2-like phenotypes, but whether reduced macrophage oxidative function causes systemic insulin resistance in vivo is not clear. Here, we show that mice with reduced mitochondrial oxidative phosphorylation (OxPhos) due to myeloid-specific deletion of CR6-interacting factor 1 (Crif1), an essential mitoribosomal factor involved in biogenesis of OxPhos subunits, have M1-like polarization of macrophages and systemic insulin resistance with adipose inflammation...
April 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29674498/microenvironmental-m1-tumor-associated-macrophage-polarization-influences-cancer-related-anemia-in-advanced-ovarian-cancer-key-role-of-interleukin-6
#10
Clelia Madeddu, Giulia Gramignano, Paraskevas Kotsonis, Ferdinando Coghe, Vinicio Atzeni, Mario Scartozzi, Antonio Macciò
No abstract text is available yet for this article.
April 19, 2018: Haematologica
https://www.readbyqxmd.com/read/29674474/genetic-deletion-of-il-interleukin-19-exacerbates-atherogenesis-in-il19-%C3%A3-ldlr-double-knockout-mice-by-dysregulation-of-mrna-stability-protein-hur-human-antigen-r
#11
Mitali Ray, Khatuna Gabunia, Christine N Vrakas, Allison B Herman, Farah Kako, Sheri E Kelemen, Laurel A Grisanti, Michael V Autieri
OBJECTIVE: To test the hypothesis that loss of IL (interleukin)-19 exacerbates atherosclerosis. APPROACH AND RESULTS: Il19 -/- mice were crossed into Ldlr -/- (low-density lipoprotein receptor knock out) mice. Double knockout (dKO) mice had increased plaque burden in aortic arch and root compared with Ldlr -/- controls after 14 weeks of high-fat diet (HFD). dKO mice injected with 10 ng/g per day rmIL-19 had significantly less plaque compared with controls. qRT-PCR and Western blot analysis revealed dKO mice had increased systemic and intraplaque polarization of T cells and macrophages to proinflammatory Th 1 and M1 phenotypes, and also significantly increased TNF (tumor necrosis factor)-α expression in spleen and aortic arch compared with Ldlr -/- controls...
April 19, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29670921/roles-of-macrophage-subtypes-in-bowel-anastomotic-healing-and-anastomotic-leakage
#12
REVIEW
Jinyao Shi, Zhouqiao Wu, Ziyu Li, Jiafu Ji
Macrophages play an important role in host defense, in addition to the powerful ability to phagocytose pathogens or foreign matters. They fulfill a variety of roles in immune regulation, wound healing, and tissue homeostasis preservation. Macrophages are characterized by high heterogeneity, which can polarize into at least two major extremes, M1-type macrophages (classical activation) which are normally derived from monocytes and M2-type macrophages (alternative activation) which are mostly those tissue-resident macrophages...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29670625/immunology-of-cryptococcal-infections-developing-a-rational-approach-to-patient-therapy
#13
REVIEW
Waleed Elsegeiny, Kieren A Marr, Peter R Williamson
Cryptococcal meningoencephalitis is responsible for upwards of 15% of HIV-related deaths worldwide and is currently the most common cause of non-viral meningitis in the US, affecting both previously healthy and people with immune suppression caused by cancer chemotherapy, transplantation, and biologic therapies. Despite a continued 30-50% attributable mortality, recommended therapeutic strategies have remained largely unchanged since the 1950s. Recent murine models and human studies examining the role of the immune system in both susceptibility to the infection as well as host damage have begun to influence patient care decisions...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29670609/enhanced-replication-of-virulent-newcastle-disease-virus-in-chicken-macrophages-is-due-to-polarized-activation-of-cells-by-inhibition-of-tlr7
#14
Pingze Zhang, Zhuang Ding, Xinxin Liu, Yanyu Chen, Junjiao Li, Zhi Tao, Yidong Fei, Cong Xue, Jing Qian, Xueli Wang, Qingmei Li, Tobias Stoeger, Jianjun Chen, Yuhai Bi, Renfu Yin
Newcastle disease (ND), caused by infections with virulent strains of Newcastle disease virus (NDV), is one of the most important infectious disease affecting wild, peridomestic, and domestic birds worldwide. Vaccines constructed from live, low-virulence (lentogenic) viruses are the most accepted prevention and control strategies for combating ND in poultry across the globe. Avian macrophages are one of the first cell lines of defense against microbial infection, responding to signals in the microenvironment...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29670256/deviations-of-the-immune-cell-landscape-between-healthy-liver-and-hepatocellular-carcinoma
#15
Nataliya Rohr-Udilova, Florian Klinglmüller, Rolf Schulte-Hermann, Judith Stift, Merima Herac, Martina Salzmann, Francesca Finotello, Gerald Timelthaler, Georg Oberhuber, Matthias Pinter, Thomas Reiberger, Erika Jensen-Jarolim, Robert Eferl, Michael Trauner
Tumor-infiltrating immune cells are highly relevant for prognosis and identification of immunotherapy targets in hepatocellular carcinoma (HCC). The recently developed CIBERSORT method allows immune cell profiling by deconvolution of gene expression microarray data. By applying CIBERSORT, we assessed the relative proportions of immune cells in 41 healthy human livers, 305 HCC samples and 82 HCC adjacent tissues. The obtained immune cell profiles provided enumeration and activation status of 22 immune cell subtypes...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29667418/granulatosides-d-e-and-other-polar-steroid-compounds-from-the-starfish-choriaster-granulatus-their-immunomodulatory-activity-and-cytotoxicity
#16
Natalia V Ivanchina, Alla A Kicha, Timofey V Malyarenko, Sofiya D Ermolaeva, Ekaterina A Yurchenko, Evgeny A Pislyagin, Chau Van Minh, Pavel S Dmitrenok
Two new steroid glycosides, granulatosides D (1) and E (2), belonging to the group of bi- and monoglycosides of polyhydroxysteroids, respectively, were isolated from the ethanolic extract of the starfish Choriaster granulatus along with thirteen previously known glycosides of polyhydroxysteroids (3-15) and one steroid heptaol (16). The structures of the new compounds were elucidated by extensive NMR and ESIMS techniques. Cytotoxic and immunomodulatory activities of compounds 1, 3-8, and 10-16 using murine splenocytes and peritoneal macrophages were studied...
April 18, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29666270/mk2-contributes-to-tumor-progression-by-promoting-m2-macrophage-polarization-and-tumor-angiogenesis
#17
Lucia Suarez-Lopez, Ganapathy Sriram, Yi Wen Kong, Sandra Morandell, Karl A Merrick, Yuliana Hernandez, Kevin M Haigis, Michael B Yaffe
Chronic inflammation is a major risk factor for colorectal cancer. The p38/MAPKAP Kinase 2 (MK2) kinase axis controls the synthesis of proinflammatory cytokines that mediate both chronic inflammation and tumor progression. Blockade of this pathway has been previously reported to suppress inflammation and to prevent colorectal tumorigenesis in a mouse model of inflammation-driven colorectal cancer, by mechanisms that are still unclear. Here, using whole-animal and tissue-specific MK2 KO mice, we show that MK2 activity in the myeloid compartment promotes tumor progression by supporting tumor neoangiogenesis in vivo...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29666185/hepatocyte-nuclear-receptor-shp-suppresses-inflammation-and-fibrosis-in-a-mouse-model-of-nonalcoholic-steatohepatitis
#18
An Zou, Nancy Magee, Fengyan Deng, Sarah Lehn, Cuncong Zhong, Yuxia Zhang
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide, ranging from nonalcoholic fatty liver (NAFL, steatosis without hepatocellular injury) to the more aggressive nonalcoholic steatohepatitis (NASH, steatosis with ballooning, inflammation, or fibrosis). Although many studies have greatly contributed to the elucidation of NAFLD pathogenesis, the disease progression from NAFL to NASH still remains incompletely understood. Nuclear receptor small heterodimer partner (Nr0b2, SHP) is a transcriptional regulator critical for the regulation of bile acid, glucose, and lipid metabolism...
April 17, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29666049/m1-and-m2-macrophages-differentially-regulate-hematopoietic-stem-cell-self-renewal-and-ex-vivo-expansion
#19
Yi Luo, Lijian Shao, Jianhui Chang, Wei Feng, Y Lucy Liu, Michele H Cottler-Fox, Peter D Emanuel, Martin Hauer-Jensen, Irwin D Bernstein, Lingbo Liu, Xing Chen, Jianfeng Zhou, Peter J Murray, Daohong Zhou
Uncovering the cellular and molecular mechanisms by which hematopoietic stem cell (HSC) self-renewal is regulated can lead to the development of new strategies for promoting ex vivo HSC expansion. Here, we report the discovery that alternative (M2)-polarized macrophages (M2-MΦs) promote, but classical (M1)-polarized macrophages (M1-MΦs) inhibit, the self-renewal and expansion of HSCs from mouse bone marrow (BM) in vitro. The opposite effects of M1-MΦs and M2-MΦs on mouse BM HSCs were attributed to their differential expression of nitric oxide synthase 2 (NOS2) and arginase 1 (Arg1), because genetic knockout of Nos2 and Arg1 or inhibition of these enzymes with a specific inhibitor abrogated the differential effects of M1-MΦs and M2-MΦs...
April 24, 2018: Blood Advances
https://www.readbyqxmd.com/read/29662760/macrophages-and-bone-inflammation
#20
REVIEW
Qiaoli Gu, Huilin Yang, Qin Shi
Bone metabolism is tightly regulated by the immune system. Accelerated bone destruction is observed in many bone diseases, such as rheumatoid arthritis, fracture, and particle-induced osteolysis. These pathological conditions are associated with inflammatory responses, suggesting the contribution of inflammation to bone destruction. Macrophages are heterogeneous immune cells and are polarized into the proinflammatory M1 and antiinflammatory M2 phenotypes in different microenvironments. The cytokines produced by macrophages depend on the macrophage activation and polarization...
July 2017: Journal of Orthopaedic Translation
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