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https://www.readbyqxmd.com/read/28074263/treatment-options-and-outcome-after-bony-avulsion-of-the-flexor-digitorum-profundus-tendon-a-review-of-29-cases
#1
Gabriel Halát, Lukas Negrin, Jochen Erhart, Robin Ristl, Stefan Hajdu, Patrick Platzer
INTRODUCTION: The objective of this retrospective review was to evaluate the functional and esthetic outcomes in patients with non- or minimally (<2 mm), and severely (>2 mm) displaced bony avulsions of the flexor digitorum profundus (FDP) tendon. MATERIALS AND METHODS: Between 1996 and 2010, 29 patients with a bony avulsion of the FDP tendon were treated. The displacement magnitude of the avulsed fragment determined, whether conservative or surgical treatment was performed...
January 10, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28072735/localized-type-volkmann-s-contracture-treated-with-tendon-transfer-and-tension-reduced-early-mobilization-a-case-report
#2
Yoshio Kaji, Osamu Nakamura, Konosuke Yamaguchi, Sachiko Tobiume, Tetsuji Yamamoto
RATIONALE: For localized type Volkmann's contracture, in which degeneration of the flexor digitorum profundus (FDP) muscle to one or two fingers and restriction of finger extension occur, dissection or excision of the affected muscle is usually recommended. However, these surgical procedures need relatively wide exposure of the muscle, because the FDP muscle is in the deep portion of the forearm. PATIENT CONCERNS: In this report, the case of a 35-year-old woman with localized type Volkmann's contracture is presented...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28069200/effects-of-low-intensity-ultrasound-on-the-growth-cell-membrane-permeability-and-ethanol-tolerance-of-saccharomyces-cerevisiae
#3
Chunhua Dai, Feng Xiong, Ronghai He, Weiwei Zhang, Haile Ma
Effects of low-intensity ultrasound (at different frequency, treatment time and power) on Saccharomyces cerevisiae in different growth phase were evaluated by the biomass in the paper. In addition, the cell membrane permeability and ethanol tolerance of sonicated Saccharomyces cerevisiae were also researched. The results revealed that the biomass of Saccharomyces cerevisiae increased by 127.03% under the optimum ultrasonic conditions such as frequency 28kHz, power 140W/L and ultrasonic time 1h when Saccharomyces cerevisiae cultured to the latent anaphase...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28057800/olefin-isomers-of-a-triazole-bisphosphonate-synergistically-inhibit-geranylgeranyl-diphosphate-synthase
#4
Cheryl Allen, Sandhya Kortagere, Huaxiang Tong, Robert A Matthiesen, Joseph I Metzger, David F Wiemer, Sarah A Holstein
The isoprenoid donor for protein geranylgeranylation reactions, geranylgeranyl diphosphate (GGDP), is the product of the enzyme GGDP synthase (GGDPS) which condenses farnesyl diphosphate (FDP) and isopentenyl pyrophosphate. GGDPS inhibition is of interest from a therapeutic perspective for multiple myeloma as we have shown that targeting Rab GTPase geranylgeranylation impairs monoclonal protein trafficking, leading to endoplasmic reticulum stress and apoptosis. We have reported a series of triazole bisphosphonate GGDPS inhibitors of which the most potent was a 3:1 mixture of homogeranyl (HG) and homoneryl (HN) isomers...
January 5, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28045196/mechanistic-studies-of-sesquiterpene-cyclases-based-on-their-carbon-isotope-ratios-at-natural-abundance
#5
Wenhua Tan, Stefan Bartram, Wilhelm Boland
During the process of terpene biosynthesis, C-C bond breaking and forming steps are subjected to kinetic carbon isotope effects, leading to distinct carbon isotopic signatures of the products. Accordingly, carbon isotopic signatures could be used to reveal the "biosynthetic history" of the produced terpenoids. Five known sesquiterpene cyclases, regulating three different pathways, representing simple to complex biosynthetic sequences, were heterologously expressed and used for in vitro assays with farnesyl diphosphate as substrate...
January 3, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28041822/effect-of-leukapheresis-on-blood-coagulation-in-patients-with-hyperleukocytic-acute-myeloid-leukemia
#6
Andry Van de Louw
INTRODUCTION: Leukapheresis has been proposed to reduce white blood cell (WBC) count in hyperleukocytic acute myeloid leukemia (AML). However, no survival benefit has been proven and leukapheresis can potentially affect coagulation and worsen bleeding and disseminated intravascular coagulation (DIC). We analyzed the effect of leukapheresis on coagulation tests in a cohort of hyperleukocytic AML patients. METHODS: Retrospective chart review of hyperleukocytic AML patients who underwent leukapheresis between 2003 and 2014...
December 29, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/27995653/influence-of-misfit-on-the-occurrence-of-veneering-porcelain-fractures-chipping-in-implant-supported-metal-ceramic-fixed-dental-prostheses-an-in%C3%A2-vitro-pilot-trial
#7
Nils Löfgren, Christel Larsson, Nikos Mattheos, Martin Janda
OBJECTIVE: Technical complications such as veneer fractures are more common in implant-supported than tooth-supported restorations. The underlying causes have not been fully identified. The aim of this study was to evaluate whether misfit between the restoration and the implant may affect the risk of veneer fractures. MATERIALS AND METHODS: Twenty standardized five-unit implant-supported metal-ceramic fixed dental prostheses (FDP)s were manufactured and fixed in acrylic blocks...
December 19, 2016: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/27975099/paradoxical-bleeding-and-thrombotic-episodes-of-dysprothrombinaemia-due-to-a-homozygous-arg382his-mutation
#8
Qiulan Ding, Likui Yang, Xiaoqing Zhao, Wenman Wu, Xuefeng Wang, Alireza R Rezaie
We have characterised the pathogenic basis of dysprothrombinaemia in a patient exhibiting paradoxical bleeding and thrombotic defects during pregnancy and postpartum. Genetic analysis revealed that the proband is homozygous for the prothrombin Arg382His mutation, possessing only ~1 % clotting activity. The proband experienced severe bleeding episodes during her pregnancy, which required treatment with prothrombin complex concentrates, and then pulmonary embolism and deep-vein thrombosis at 28 days postpartum, which required treatment with LMWH and fresh frozen plasma...
December 15, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27959540/unbiased-false-discovery-rate-estimation-for-shotgun-proteomics-based-on-the-target-decoy-approach
#9
Lev I Levitsky, Mark V Ivanov, Anna A Lobas, Mikhail V Gorshkov
Target-decoy approach (TDA) is the dominant strategy for false discovery rate (FDR) estimation in mass-spectrometry-based proteomics. One of its main applications is direct FDR estimation based on counting of decoy matches above a certain score threshold. The corresponding equations are widely employed for filtering of peptide or protein identifications. In this work we consider a probability model describing the filtering process and find that, when decoy counting is used for q value estimation and subsequent filtering, a correction has to be introduced into these common equations for TDA-based FDR estimation...
December 13, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27941590/traumatic-hemothorax-blood-contains-elevated-levels-of-microparticles-that-are-prothrombotic-but-inhibit-platelet-aggregation
#10
Thomas A Mitchell, Maryanne C Herzig, Chriselda G Fedyk, Marc A Salhanick, Aaron T Henderson, Bijaya K Parida, Nicolas J Prat, Daniel L Dent, Martin G Schwacha, Andrew P Cap
OBJECTIVES: Autotransfusion of shed blood from traumatic hemothorax is an attractive option for resuscitation of trauma patients in austere environments. However, previous analyses revealed that shed hemothorax (HX) blood is defibrinated, thrombocytopenic, and contains elevated levels of D-dimer. Mixing studies with normal pooled plasma demonstrated hypercoagulability, evoking concern for potentiation of acute traumatic coagulopathy. We hypothesized that induction of coagulopathic changes by shed HX blood may be due to increases in cellular microparticles (MP) and that these may also affect recipient platelet function...
December 9, 2016: Shock
https://www.readbyqxmd.com/read/27940211/fibrin-fibrinogen-degradation-products-fdp-at-hospital-admission-predict-neurological-outcomes-in-out-of-hospital-cardiac-arrest-patients
#11
Yuichi Ono, Mineji Hayakawa, Kunihiko Maekawa, Akira Kodate, Yoshihiro Sadamoto, Naoki Tominaga, Hiromoto Murakami, Tomonao Yoshida, Kenichi Katabami, Takeshi Wada, Hisako Sageshima, Atsushi Sawamura, Satoshi Gando
OBJECTIVE: This study aimed to test the hypothesis that coagulation, fibrinolytic markers and disseminated intravascular coagulation (DIC) score (International Society on Thrombosis and Haemostasis) at hospital admission of out-of-hospital cardiac arrest (OHCA) patients can predict neurological outcomes 1 month after cardiac arrest. METHODS: In this retrospective, observational analysis, data were collected from the Sapporo Utstein Registry and medical records at Hokkaido University Hospital...
February 2017: Resuscitation
https://www.readbyqxmd.com/read/27916594/application-of-abbreviated-protocol-of-magnetic-resonance-imaging-for-breast-cancer-screening-in-dense-breast-tissue
#12
Shuang-Qing Chen, Min Huang, Yu-Ying Shen, Chen-Lu Liu, Chuan-Xiao Xu
RATIONALE AND OBJECTIVES: The study aimed to evaluate the usefulness of an abbreviated protocol (AP) of magnetic resonance imaging (MRI) in comparison to a full diagnostic protocol (FDP) of MRI in the breast cancer screening with dense breast tissue. MATERIALS AND METHODS: There are 478 female participants with dense breast tissue and negative mammography results, who were imaged with MRI using AP and FDP. The AP and FDP images were analyzed separately, and the sensitivity and specificity of breast cancer detection were calculated...
December 1, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27916104/-preparation-and-application-of-monoclonal-antibodies-against-dr-region-of-na-k-atpase-%C3%AE-1-subunit
#13
Xiaofei Yan, Litao Wu, Xiaojuan DU, Jing Li, Fujun Zhang, Yan Han, Shemin Lyu, Dongmin Li
Objective To prepare monoclonal antibodies against DR region (897DVEDSYGQQWTYEQR911) of Na(+)-K(+)-ATPase α1 subunit and identify their properties. Methods BALB/c mice were immunized with DR-keyholelimpet hemocyanin (KLH). Splenocytes from the immunized mice were collected and subsequently fused with SP2/0 mouse myeloma cells. Positive hybridoma clones were obtained after cell fusion and selection. ELISA was used to detect DR antibody titer in the cell supernatants. DR region-specific monoclonal antibodies were analyzed by dot blotting, Western blotting and immunofluorescence assay...
December 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27880023/effect-of-cyclic-fatigue-tests-on-aging-and-their-translational-implications-for-survival-of-all-ceramic-tooth-borne-single-crowns-and-fixed-dental-prostheses
#14
REVIEW
Mutlu Özcan, Moritz Jonasch
PURPOSE: The objective of this systematic review was to elaborate the aging effect of cyclic fatigue tests on mechanical durability of all-ceramic single crowns and fixed dental prostheses (FDP). MATERIALS AND METHODS: Original scientific papers published in the MEDLINE (PubMed) database in English between 01/01/1950 and 12/31/2013 on cyclic loading on all-ceramics were included in this systematic review. The following MeSH terms, search terms, and their combinations were used: "in vitro," "stress mechanical," "crowns," "denture, partial, fixed," "dentistry," "fatigue," "all-ceramic," "zirconia," "fixed dental prosthesis," "FDP," "bridges," and "cyclic loading...
November 23, 2016: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/27869629/coagulation-profile-of-patients-with-adolescent-idiopathic-scoliosis-undergoing-posterior-spinal-fusion
#15
Patrick Bosch, Tanya S Kenkre, Joanne A Londino, Antonio Cassara, Charles Yang, Jonathan H Waters
BACKGROUND: Blood loss and transfusion requirements during posterior spinal fusion for adolescent idiopathic scoliosis remain a concern. The mechanism of bleeding in these patients is poorly characterized. Thromboelastography is a comprehensive test of a patient's coagulation system commonly used in cardiac surgical procedures. It has not been well studied for use in patients with adolescent idiopathic scoliosis. METHODS: A prospective, observational study of the coagulation profile of patients with adolescent idiopathic scoliosis undergoing posterior spinal fusion is presented...
October 19, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27859471/volumetric-changes-at-pontic-sites-with-or-without-soft-tissue-grafting-a-controlled-clinical-study-with-a-10-year-follow-up
#16
Stefan P Bienz, Irena Sailer, Ignacio Sanz-Martin, Ronald E Jung, Christoph H F Hämmerle, Daniel S Thoma
OBJECTIVE: to evaluate volumetric changes of soft tissues at pontic sites in patients treated with or without soft tissue grafting over an observation period of 10 years. MATERIALS AND METHODS: A total of 17 patients receiving a tooth-borne fixed dental prosthesis (FDP) were enrolled in this study. Nine patients received a subepithelial connective tissue graft at the pontic site (test). Eight patients continued without soft tissue grafting (control). Baseline impressions were taken after delivery of the final FDP and at 10 years...
November 17, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27853760/enzymatic-synthesis-of-natural-aristolochene-from-a-non-natural-substrate
#17
Juan A Faraldos, Daniel J Grundy, Oscar Cascon, Stefano Leoni, Marc W van der Kamp, Rudolf K Allemann
The sesquiterpene cyclase aristolochene synthase from Penicillium roquefortii (PR-AS) has evolved to catalyse with high specificity (92%) the conversion of farnesyl diphosphate (FDP) to the bicyclic hydrocarbon (+)-aristolochene, the natural precursor of several fungal toxins. Here we report that PR-AS converts the unnatural FDP isomer 7-methylene farnesyl diphosphate to (+)-aristolochene via the intermediate 7-methylene germacrene A. Within the confined space of the enzyme's active site, PR-AS stabilises the reactive conformers of germacrene A and 7-methylene germacrene A, respectively, which are protonated by the same active site acid (most likely HOPPi) to yield the shared natural bicyclic intermediate eudesmane cation, from which (+)-aristolochene is then generated...
November 17, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27849977/337-fdp-level-at-hospital-admission-predicts-neurologic-outcomes-in-out-of-hospital-cardiac-arrest
#18
Yu-Ichi Ono, Tomonao Yoshida, Mineji Hayakawa, Kunihiko Maekawa, Hiromoto Murakami, Kenichi Katabami, Atsushi Sawamura, Satoshi Gando
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27830875/oblique-cord-chorda-obliqua-of-the-forearm-and-muscle-associated-fibrous-tissues-at-and-around-the-elbow-joint-a-study-of-human-foetal-specimens
#19
Z W Jin, Y Jin, M Yamamoto, H Abe, G Murakami, T F Yan
In adults, the oblique cord or chorda obliqua separates the origins of the flexor pollicis longus (FPL) and flexor digitorum profundus (FDP) muscles from the supinator muscle and elbow joint. This study examined the topographic anatomy of the oblique cord and related muscles in foetuses. Semiserial sections of five mid-term foetuses of gestational age (GA) 14-16 weeks and 12 late-stage foetuses of GA 28-30 weeks were histologically examined and three forearms at GA 30 weeks were macroscopically evaluated. Late-stage foetuses showed a fascial structure between the supinator and FDP muscles...
2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27816011/sleep-alertness-and-alertness-management-among-commercial-airline-pilots-on-short-haul-and-long-haul-flights
#20
Mikael Sallinen, Maria Sihvola, Sampsa Puttonen, Kimmo Ketola, Antti Tuori, Mikko Härmä, Göran Kecklund, Torbjörn Åkerstedt
Airline pilots' sleep and on-duty alertness are important focus areas in commercial aviation. Until now, studies pertaining to this topic have mainly focused on specific characteristics of flights and thus a comprehensive picture of the matter is not well established. In addition, research knowledge of what airline pilots actually do to maintain their alertness while being on duty is scarce. To address these gaps in research knowledge, we conducted a field study on a representative sample of the airline pilots of a medium-sized airline...
January 2017: Accident; Analysis and Prevention
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