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https://www.readbyqxmd.com/read/29753263/the-hirisplex-s-system-for-eye-hair-and-skin-colour-prediction-from-dna-introduction-and-forensic-developmental-validation
#1
Lakshmi Chaitanya, Krystal Breslin, Sofia Zuñiga, Laura Wirken, Ewelina Pośpiech, Magdalena Kukla-Bartoszek, Titia Sijen, Peter de Knijff, Fan Liu, Wojciech Branicki, Manfred Kayser, Susan Walsh
Forensic DNA Phenotyping (FDP), i.e. the prediction of human externally visible traits from DNA, has become a fast growing subfield within forensic genetics due to the intelligence information it can provide from DNA traces. FDP outcomes can help focus police investigations in search of unknown perpetrators, who are generally unidentifiable with standard DNA profiling. Therefore, we previously developed and forensically validated the IrisPlex DNA test system for eye colour prediction and the HIrisPlex system for combined eye and hair colour prediction from DNA traces...
April 12, 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29745890/pattern-of-muscle-involvement-in-inclusion-body-myositis-a-sonographic-study
#2
Jemima Albayda, Lisa Christopher-Stine, Clifton O Bingham Iii, Julie J Paik, Eleni Tiniakou, Seth Billings, O Manny Uy, Philippe Burlina
OBJECTIVES: Imaging plays a role in myositis assessment by detecting muscle changes indicative of pathology. This study was conducted to determine the ultrasonographic pattern of muscle involvement in patients with inclusion body myositis (IBM) through an assessment of muscle echointensity. METHODS: Sixty-two individuals were consecutively studied, 18 with IBM, 16 with polymyositis or dermatomyositis and 28 normal controls. Standardised scans were completed bilaterally for the deltoids, biceps, flexor digitorum profundus (FDP), flexor carpi ulnaris, rectus femoris, tibialis anterior and gastrocnemius assessing for muscle echointensity changes...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29744210/a-strain-gauge-analysis-comparing-4-unit-veneered-zirconium-dioxide-implant-borne-fixed-dental-prosthesis-on-engaging-and-non-engaging-abutments-before-and-after-torque-application
#3
Alyssa Epprecht, Marco Zeltner, Goran Benic, Mutlu Özcan
This study quantified the strain development after inserting implant-borne fixed dental prosthesis (FDP) to various implant-abutment joints. Two bone-level implants (∅ = 4.1 mm, RC, SLA 10 mm, Ti, Straumann) were inserted in polyurethane models (N = 3) in the area of tooth nos 44 and 47. Four-unit veneered zirconium dioxide FDPs (n = 2) were fabricated, one of which was fixed on engaging (E; RC Variobase, ∅ = 4.5 mm, H = 3.5 mm) and the other on non-engaging (NE) abutments (RC Variobase, ∅ = 4...
February 2018: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29739066/basic-evaluation-of-the-newly-developed-lias-auto-p-fdp-assay-and-the-influence-of-plasmin-%C3%AE-2-plasmin-inhibitor-complex-values-on-discrepancy-in-the-comparison-with-lias-auto-d-dimer-neo-assay
#4
Osamu Kumano, Masahiro Ieko, Yutaka Komiyama, Sumiyoshi Naito, Mika Yoshida, Nobuhiko Takahashi, Kazumasa Ohmura, Junki Hayasaki, Mineji Hayakawa
BACKGROUND: Laboratory determination of fibrin/fibrinogen degradation products (FDP) levels, along with that of the D-dimer, is important for assessing the fibrinolytic situation. Recently, we developed a new FDP reagent "Lias Auto P-FDP", which can detect various FDP fragments. The purpose of this study was to evaluate the basic performance of the newly developed Lias Auto P-FDP and compare it with Lias Auto D-Dimer Neo assay. METHODS: The within-run precision of Lias Auto P-FDP and Lias Auto D-Dimer was determined 20 times in low and high value controls...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29732741/an-enzyme-responsive-turn-on-fluorescence-polymeric-superamphiphile-as-a-potential-visualizable-phosphate-prodrug-delivery-vehicle
#5
Xi Yang, Shihong Shen, Li Guo, Jidong Tan, Henxin Lei, Jianghan Wu, Lei Zhao, Tao Xiong, Youshen Wu, Yilong Cheng, Yanfeng Zhang
The development of inexpensive and highly efficient enzyme-responsive polymers has significantly contributed to targeted drug delivery systems. Here, a superamphiphile with a capability of fluorescent dissociation sensing is designed. It is constructed with negatively charged adenosine 5'-triphosphate (ATP) and negatively charged fluorescein diphosphate (FDP), which are used as fluorescence detection, and a cationic diblock copolymer methoxy-poly(ethylene glycol)113 -b-poly(2-dimethyl-aminoethyl methacrylate)70 ...
May 7, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29728555/prosthetic-rehabilitation-using-a-telescopic-crown-constructed-with-computer-assisted-design-and-computer-assisted-manufacturing-a-case-report-with-a-2-year-follow-up
#6
Nasser M Al Ahmari
Aim and background: This case report describes a 74-year-old female patient whose teeth were rehabilitated using telescopic crowns (TCs) on abutments and fixed dental prostheses (FDPs) in the maxillary arch with the aid of computer-assisted design and computer-assisted manufacturing (CAD/CAM) technology. The mandibular arch was restored using casted removable dental prostheses (RDPs) and surveyed crowns. Case report: The treatment sequences were followed as recommended in the dental literature. First, existing defective restorations were eliminated, caries was removed, and excellent mouth preparation was performed...
April 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29725715/fermented-dairy-products-consumption-is-associated-with-attenuated-cortical-bone-loss-independently-of-total-calcium-protein-and-energy-intakes-in-healthy-postmenopausal-women
#7
E Biver, C Durosier-Izart, F Merminod, T Chevalley, B van Rietbergen, S L Ferrari, R Rizzoli
A longitudinal analysis of bone microstructure in postmenopausal women of the Geneva Retirees Cohort indicates that age-related cortical bone loss is attenuated at non-bearing bone sites in fermented dairy products consumers, not in milk or ripened cheese consumers, independently of total energy, calcium, or protein intakes. INTRODUCTION: Fermented dairy products (FDP), including yogurts, provide calcium, phosphorus, and proteins together with prebiotics and probiotics, all being potentially beneficial for bone...
May 3, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29707612/fracture-load-of-colored-and-non-colored-high-translucent-zirconia-three-unit-fixed-dental-prosthesis-frameworks
#8
Deyar Jallal Hadi Mahmood, Michael Braian, Abdul-Salam Khan, Armin Shabaz, Christel Larsson
Aim: The use of colored translucent zirconia may enable restorations of a more natural tooth-like appearance than previous opaque white zirconia. The shift from non-colored to colored zirconia may however entail a risk of reduced strength. The aim of the present study was to compare fracture load and fracture mode of fixed dental prostheses frameworks made of colored translucent zirconia to that of non-colored controls. Methods: A total of forty three-unit FDP frameworks were manufactured from two different high translucent zirconia materials (Zenostar, Wieland Dental, and DD cubeX2, Dental Direkt)...
2018: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/29682191/incidence-and-risk-factors-for-venous-thromboembolism-in-patients-with-pretreated-advanced-pancreatic-carcinoma
#9
Shunsuke Kondo, Mitsuhito Sasaki, Hiroko Hosoi, Yasunari Sakamoto, Chigusa Morizane, Hideki Ueno, Takuji Okusaka
Patients with pancreatic carcinoma are at an increased risk of venous thromboembolism (VTE), which is a major cause of morbidity and mortality in various types of cancer. The aim of this study was to determine the incidence and clinical significance of VTE in patients with pancreatic carcinoma, and to identify biomarkers for the detection of VTE in these patients. The eligibility criteria were chemo-naïve patients with primary pancreatic carcinoma, an Eastern Cooperative Oncology Group performance status of 0-2, and adequate organ function...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29613931/comparison-of-autograft-and-allograft-with-surface-modification-for-flexor-tendon-reconstruction-a-canine-in-vivo-model
#10
Zhuang Wei, Ramona L Reisdorf, Andrew R Thoreson, Gregory D Jay, Steven L Moran, Kai-Nan An, Peter C Amadio, Chunfeng Zhao
BACKGROUND: Flexor tendon injury is common, and tendon reconstruction is indicated clinically if the primary repair fails or cannot be performed immediately after tendon injury. The purpose of the current study was to compare clinically standard extrasynovial autologous graft (EAG) tendon and intrasynovial allogeneic graft (IAG) that had both undergone biolubricant surface modification in a canine in vivo model. METHODS: Twenty-four flexor digitorum profundus (FDP) tendons from the second and fifth digits of 12 dogs were used for this study...
April 4, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29575329/hunting-the-main-player-enabling-chlamydomonas-reinhardtii-growth-under-fluctuating-light
#11
Martina Jokel, Xenie Johnson, Gilles Peltier, Eva-Mari Aro, Yagut Allahverdiyeva
Photosynthetic organisms have evolved numerous photoprotective mechanisms and alternative electron sinks/pathways to fine-tune the photosynthetic apparatus under dynamic environmental conditions, such as varying carbon supply or fluctuations in light intensity. In cyanobacteria flavodiiron proteins (FDPs) protect the photosynthetic apparatus from photodamage under fluctuating light (FL). In Arabidopsis thaliana, which does not possess FDPs, the PGR5-related pathway enables FL photoprotection. The direct comparison of the pgr5, pgrl1 and flv knock-out mutants of Chlamydomonas reinhardtii grown under ambient air demonstrates that all three proteins contribute to the survival of cells under FL, but to varying extents...
March 25, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29569767/marginal-bone-loss-at-implants-with-different-surface-characteristics-a-20-year-follow-up-of-a-randomized-controlled-clinical-trial
#12
Mauro Donati, Annika Ekestubbe, Jan Lindhe, Jan L Wennström
OBJECTIVE: This report is a 20-year follow-up of a randomized controlled clinical trial evaluating the potential long-term effect of a modified implant surface on the preservation of the peri-implant marginal bone level. MATERIAL & METHODS: In each of 51 patients and for each fixed partial denture (FPD), by randomization at least one implant installed had a non-modified turned surface and one a modified and roughened surface (TiOblast® ). Clinical and radiological examinations were performed at various follow-up intervals...
March 23, 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29531134/two-phytoplasmas-elicit-different-responses-in-the-insect-vector-euscelidius-variegatus-kirschbaum
#13
Luciana Galetto, Simona Abbà, Marika Rossi, Marta Vallino, Massimo Pesando, Nathalie Arricau-Bouvery, Marie-Pierre Dubrana, Walter Chitarra, Mattia Pegoraro, Domenico Bosco, Cristina Marzachì
Phytoplasmas are plant pathogenic bacteria transmitted by hemipteran insects. The leafhopper Euscelidius variegatus is a natural vector of chrysanthemum yellows phytoplasma (CYp) and a laboratory vector of Flavescence dorée phytoplasma (FDp). The two phytoplasmas induce different effects on this species: CYp slightly improves, while FDp negatively affects insect fitness. To investigate the molecular bases of these different responses, RNA-seq analysis of E. variegatus infected with either CYp or FDp was performed...
March 12, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29526302/effect-of-number-of-pontics-and-impression-technique-on-the-accuracy-of-four-unit-monolithic-zirconia-fixed-dental-prostheses
#14
Woong Ki Kim, Sunjai Kim
STATEMENT OF PROBLEM: Because of their relatively small scanning area, intraoral scanners may result in less accurate fixed dental prostheses (FDPs) than do laboratory scanners. PURPOSE: The purpose of this in vitro study was to evaluate the accuracy of monolithic zirconia FDPs with different numbers of pontics fabricated with different impression techniques. MATERIAL AND METHODS: The mandibular right premolars and molars of an acrylic resin model were prepared to receive 4-unit FDPs...
March 8, 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29518875/-the-8-year-follow-up-study-for-clinical-diagnostic-potentials-of-frequency-doubling-technology-perimetry-for-perimetrically-normal-eyes-of-open-angle-glaucoma-patients-with-unilateral-visual-field-loss
#15
X Fan, L L Wu, G G Xiao, Z Z Ma, F Liu
Objective: To analyze potentials of frequency-doubling technology perimetry (FDP) for diagnosing open-angle glaucoma (OAG) in perimetrically normal eyes of OAG patients diagnosed with standard automated perimetry (SAP) and relating factors from abnormalities on FDP to visual field loss on SAP. Methods: A prospective cohort study. Sixty-eight eyes of 68 OAG patients visiting the ophthalmic clinic of Peking University Third Hospital during November 2003 and October 2007 [32 primary open-angle glaucoma patients and 36 normal tension glaucoma patients, 32 males and 36 females, with an average age of (59±13) years] with unilateral field loss detected by SAP (Octopus101 tG2 program) were examined with the FDP N-30 threshold program (Humphrey Instruments) at baseline...
March 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29513969/evaluation-of-anticoagulant-effect-of-sulfated-polysaccharide-sps-from-codium-dwarkense-borgesen-in-%C3%AE%C2%BA-carrageenan-induced-hypercoagulable-state-in-wistar-albino-rats
#16
Hiral N Golakiya, Viren N Naik, Hiren N Hirapara, Kalpanaben H Mody, Alpesh P Goswami, Chandrabhanu Tripathi
Our aim of the present study was to evaluate the anticoagulant effect of sulfated polysaccharides (SPS) from Codium dwarkense Bergesen in ic-carrageenan induced hypercoagulable state in Wistar albino rats. 48 Wistar albino rats of either sex were randomly divided into 6 groups - disease control, active control, treatment lowmand high dose and preventive low and high dose. K-Carrageenan (3 mg/kg) single dose intravenously was given in rat tail vein at pre-decided time to produce hypercoagulable state. Baseline, 24, 48 and 72 hours duration blood samples were collected for PT, INR, aPTT, platelet count and fibrinogen level, FDP and D-Dimer measurements...
May 2017: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/29511940/retrospective-analysis-on-the-clinical-outcomes-of-recombinant-human-soluble-thrombomodulin-for-disseminated-intravascular-coagulation-syndrome-associated-with-solid-tumors
#17
Kota Ouchi, Shin Takahashi, Sonoko Chikamatsu, Shukuei Ito, Yoshikazu Takahashi, Sadayuki Kawai, Akira Okita, Yuki Kasahara, Yoshinari Okada, Hiroo Imai, Keigo Komine, Ken Saijo, Masahiro Takahashi, Hidekazu Shirota, Masanobu Takahashi, Makio Gamoh, Chikashi Ishioka
BACKGROUND: Recombinant human soluble thrombomodulin (rTM) has been established and introduced in the clinic as a standard treatment for disseminated intravascular coagulation (DIC). However, the efficacy and safety of rTM for DIC associated with solid tumors (DIC-STs) have not been fully established. Here, we performed a retrospective analysis of the clinical outcomes of rTM for DIC-STs and considered a treatment strategy with rTM for DIC-STs. METHODS: Patients with DIC-STs between November 2009 and March 2016 in 2 cancer core hospitals were retrospectively analyzed...
March 7, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29505702/fibrinolytic-abnormality-associated-with-progression-of-pediatric-solid-tumor
#18
Takashi Ishihara, Keiji Nogami, Yasufumi Takeshita, Satoshi Ochi, Midori Shima
BACKGROUND: Thrombosis and hemorrhage are serious complications of pediatric solid tumor, and enhanced fibrinolysis associated with disseminated intravascular coagulation (DIC) is often observed. Fibrinolytic enzymes also play an important role in metastasis. Limited information is available, however, on the assessment of overall hemostatic function in children with malignant solid tumor. METHODS: We have investigated the comprehensive hemostatic potential in these circumstances using simultaneous thrombin/plasmin generation assay (T/P-GA)...
March 5, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29485009/oral-submucous-fibrosis-as-an-overhealing-wound-implications-in-malignant-transformation
#19
Mohit Sharma, Smitha Sammith Shetty, Raghu Radhakrishnan
BACKGROUND: Oral submucous fibrosis is an oral potentially malignant disorder with high incidence of malignant transformation and rising global prevalence. However, the genesis of oral submucous fibrosis is still unclear despite superfluity of literature. In the background of ineffective treatment, it is necessary to decode its onset and progression before designing customized treatment regimens. OBJECTIVE: The objective of this article is to decipher the pathogenesis of oral submucous fibrosis in order to identify novel drug targets...
February 26, 2018: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/29479876/role-of-the-fibrinogen-degradation-products-and-d-dimer-in-the-differential-diagnosis-of-pulmonary-tuberculosis-and-community-acquired-pneumonia
#20
Wang Min, Jiang Zi-Feng, Xu Jian-Lin, Fang Hao-Hui
BACKGROUND: Differential diagnosis between pulmonary tuberculosis (TB) and community acquired pneumonia (CAP) is often difficult. Pulmonary TB could induce a systemic hypercoagulable state. The present study aims to investigate whether fibrinogen degradation products (FDP) and D-dimer play a diagnostic role for pulmonary TB. METHODS: We retrospectively analyzed the clinical and laboratory characteristics of 192 patients with activated pulmonary TB and 110 patients with CAP...
January 1, 2018: Clinical Laboratory
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