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https://www.readbyqxmd.com/read/28228977/transient-hemi-lower-limb-ischemia-in-the-newborn-arterial-thrombosis-or-persistent-sciatic-artery
#1
Makiko Kirino, Masayuki Ochiai, Masako Ichiyama, Hirosuke Inoue, Takeshi Kusuda, Tadamune Kinjo, Masataka Ishimura, Shouichi Ohga
Neonatal thromboembolism occurs with various predispositions and triggers. Early diagnosis of the thrombosis is challenging and essential for the therapeutic interventions. We herein report two newborns who presented with transient hemi-lower limb ischemia due to (1) arterial thrombosis or (2) a persistent sciatic artery (PSA). The patient with arterial thrombosis showed elevations of fibrin degradation product and D-dimer and received antithrombin and heparin intravenously. The patient with PSA was immediately assessed by a contrast-enhanced computed tomography because of a transient ischemic episode with no evidence of hypercoagulability...
January 2017: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/28213823/long-term-resistance-exercise-induced-muscular-hypertrophy-is-associated-with-autophagy-modulation-in-rats
#2
Insu Kwon, Yongchul Jang, Joon-Yong Cho, Young C Jang, Youngil Lee
Elevation of anabolism and concurrent suppression of catabolism are critical metabolic adaptations for muscular hypertrophy in response to resistance exercise (RE). Here, we investigated if RE-induced muscular hypertrophy is acquired by modulating a critical catabolic process autophagy. Male Wistar Hannover rats (14 weeks old) were randomly assigned to either sedentary control (SC, n = 10) or resistance exercise (RE, n = 10). RE elicited significant hypertrophy of flexor digitorum profundus (FDP) muscles in parallel with enhancement in anabolic signaling pathways (phosphorylation of AKT, mTOR, and p70S6K)...
February 17, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28208883/fostering-educational-research-among-medical-teachers-evaluation-of-a-faculty-development-program-in-india
#3
Tripti K Srivastava, Lalitbhushan S Waghmare, Alka Rawekar, Ved Prakash Mishra
INTRODUCTION: Medical education can be enormously benefitted from research. Since clinicians/medical teachers are directly involved in teaching learning processes, they should participate in Educational Research (ER) practices to generate evidence and insights about teaching learning. Faculty Development Program (FDP) has a positive influence amongst health professionals and therefore can prove to be of consequence in instilling a strong educational research culture. AIM: Present study was undertaken to evaluate the efficacy of a Faculty Development Fellowship Program in Medical Education to foster educational research culture amongst medical teachers...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28205464/a-new-classification-scheme-for-closed-avulsion-injuries-of-the-flexor-digitorum-profundus-tendon
#4
Mokhtar Abdul Azeem, Yousef Marwan, Ahmed El Morshidy, Ali Esmaeel, Yehia Zakaria
BACKGROUND: Closed avulsion injury of the flexor digitorum profundus (FDP) tendon is a relatively common condition of the hand. Its present classification system seems to be deficient in including all possible patterns of injury, leading to improper selection of the best treatment method for the injury. We aim to provide a new classification scheme for this injury. METHODS: We developed a new classification scheme based on the possible pattern of FDP tendon injury...
March 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28195730/alternate-cyclization-cascade-initiated-by-substrate-isomer-in-multiproduct-terpene-synthase-from-medicago-truncatula
#5
Abith Vattekkatte, Stefan Garms, Wilhelm Boland
Promiscuity of terpene synthases results in the enormous diversity of terpenes found in nature. Multiproduct sesquiterpene synthase MtTPS5 isolated from Medicago truncatula generates 27 optically pure products from its natural substrate (2E,6E)-farnesyl diphosphate (FDP). In order to study the promiscuity of MtTPS5, (2Z,6E)-FDP an analogue of presumptive reaction intermediates from natural reaction cascade was utilized as a substrate. This stereoisomer induced a novel cyclization pathway leading to sesquiterpenes based on humulane, amorphene and himachalane skeletons...
February 14, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28188110/accuracy-and-mechanical-performance-of-passivated-and-conventional-fabricated-3-unit-fixed-dental-prosthesis-on-multi-unit-abutments
#6
Michael Stimmelmayr, Julian Groesser, Florian Beuer, Kurt Erdelt, Gerald Krennmair, Caroline Sachs, Daniel Edelhoff, Jan-Frederik Güth
PURPOSE: The aim of this study was to evaluate the fit and mechanical stability of conventional versus passive fitting 3-unit fixed dental prosthesis (FDP) screw-retained on implants. METHODS: Twenty acrylic models, each with two embedded implants, were fabricated and functioned as patient-models. Impressions were taken and 20 all-ceramic FDPs were pre-fabricated on the plaster casts. Respectively 10 FDPs were fixed on the plaster casts (group 1) and on the patient-models for passive fitting (group 2)...
February 7, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28182849/controlling-the-false-discoveries-in-lasso
#7
Hanwen Huang
The LASSO method estimates coefficients by minimizing the residual sum of squares plus a penalty term. The regularization parameter λ in LASSO controls the trade-off between data fitting and sparsity. We derive relationship between λ and the false discovery proportion (FDP) of LASSO estimator and show how to select λ so as to achieve a desired FDP. Our estimation is based on the asymptotic distribution of LASSO estimator in the limit of both sample size and dimension going to infinity with fixed ratio. We use a factor analysis model to describe the dependence structure of the design matrix...
February 9, 2017: Biometrics
https://www.readbyqxmd.com/read/28164666/validation-of-an-automated-immunoturbidimetric-assay-for-fibrinogen-fibrin-degradation-products-measurement-and-its-correlation-to-a-semi-quantitative-latex-agglutination-test
#8
Marta E Martinuzzo, Cecilia Ujhelly, Luis H Barrera, Maria A D Adamo, Marina S Lopez, Juan C Otaso, Jose Oyhamburu
BACKGROUND: Laboratory determination of fibrinogen/fibrin degradation product (FDP) levels is important as a hyperfibrinolytic state marker. The aim of the study was to verify the analytical performance of an automated immunoturbidimetric assay (AIMT) for FDP and its comparison to a latex agglutination semiquantitative (SLAT) test. METHODS: Total precision and accuracy was calculated following the EP 15-A2 protocol at two levels of controls. The protocol EP6 was performed for linearity...
November 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28160108/marginal-and-internal-fit-of-posterior-three-unit-fixed-zirconia-dental-prostheses-fabricated-with-two-different-cad-cam-systems-and-materials
#9
Joana Schönberger, Kurt-Jürgen Erdelt, Daniel Bäumer, Florian Beuer
OBJECTIVES: The purpose of this in vitro study was to compare the precision of fit of frameworks milled from semi-sintered regular zirconia and high-translucent (HT) zirconia blanks, fabricated with two different CAD/CAM systems. MATERIAL AND METHODS: Three-unit, posterior fixed dental prostheses (FDP) frameworks were fabricated for standardized dies (n = 11) with two different laboratory computer-aided design (CAD)/computer-aided manufacturing (CAM) systems (Cercon/Ceramill)...
February 4, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28155261/dietary-protein-content-and-tissue-type-control-13-c-discrimination-in-mammals-an-analytical-approach
#10
Erik A Hobbie
RATIONALE: Carbon isotope measurements on collagen and other tissues are used in modern and paleodiet studies, and relating these patterns to the dietary protein fraction (fdp ) and δ(13) C values of dietary protein and energy (lipids and carbohydrates) remains important for determining diets. METHODS: Carbon fluxes from dietary protein to tissues in feeding studies of mice, rats, and pigs were estimated to test how tissue δ(13) C values related to the δ(13) C values of dietary protein, dietary energy, fdp , or loge fdp ...
February 3, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28150188/customized-smartpeg-for-measurement-of-resonance-frequency-of-mini-dental-implants
#11
Jagjit Singh Dhaliwal, Rubens F Albuquerque, Ali Fakhry, Sukhbir Kaur, Jocelyne S Feine
BACKGROUND: One-piece narrow diameter implants (NDIs) have been recommended as "Single-tooth replacements in the anterior zones, single posterior, multiple-unit fixed dental prosthesis (FDP), edentulous jaws to be rehabilitated with FDP, and edentulous jaws rehabilitation with overdentures in situations with reduced mesiodistal space or reduced ridge width." (ITI consensus 2013). Since NDIs can be immediately loaded, it is important to be able to carry out stability testing. We developed and validated a customized SmartPeg for this type of implant to measure the Implant Stability Quotient (ISQ)...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28138893/systematic-development-of-an-abbreviated-protocol-for-screening-breast-magnetic-resonance-imaging
#12
David A Strahle, Dorothy R Pathak, Arlene Sierra, Sukamal Saha, Catherine Strahle, Kiran Devisetty
RATIONALE & OBJECTIVES: We sought to develop an abbreviated protocol (AP) for breast MRI that maximizes lesion detection by assessing each lesion not seen on mammography by each acquisition from a full diagnostic protocol (FDP). MATERIALS & METHODS: 671 asymptomatic women (mean 55.7 years, range 40-80) with a negative mammogram were prospectively enrolled in this IRB approved study. All lesions on MRI not visualized on mammography were analyzed, reported, and suspicious lesions biopsied...
January 30, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28114794/change-of-coagulation-after-novoseven%C3%A2-use-for-bleeding-during-cardiac-surgery
#13
Emi Tomita, Hajime Takase, Keiichi Tajima, Yoshihiro Suematsu
Objectives Recombinant activated factor VII has been used for the treatment of hemophilia, factor VII deficiency, and Glanzmann's thrombasthenia. Off-label uses have recently been increasing, and there are reports that recombinant activated factor VII is effective for the treatment of excessive bleeding during or after cardiovascular surgery. We retrospectively reviewed the effectiveness of recombinant activated factor VII and its influence on the coagulation system as a treatment for uncontrollable bleeding during cardiovascular surgery...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28094933/accurate-gas-phase-formation-enthalpies-of-alloys-and-refractories-decomposition-products
#14
Yury Minenkov, Valery V Sliznev, Luigi Cavallo
Accurate gas phase formation enthalpies, ΔHf, of metal oxides and halides are critical for the prediction of the stability of high temperature materials used in the aerospace and nuclear industries. Unfortunately, the experimental ΔHf values of these compounds in the most used databases, such as the NIST-JANAF database, are often reported with large inaccuracy, while some other ΔHf values clearly differ from the value predicted by CCSD(T) methods. To address this point, in this work we systematically predicted the ΔHf values of a series of these compounds having a group 4, 6, or 14 metal...
January 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28074263/treatment-options-and-outcome-after-bony-avulsion-of-the-flexor-digitorum-profundus-tendon-a-review-of-29-cases
#15
Gabriel Halát, Lukas Negrin, Jochen Erhart, Robin Ristl, Stefan Hajdu, Patrick Platzer
INTRODUCTION: The objective of this retrospective review was to evaluate the functional and esthetic outcomes in patients with non- or minimally (<2 mm), and severely (>2 mm) displaced bony avulsions of the flexor digitorum profundus (FDP) tendon. MATERIALS AND METHODS: Between 1996 and 2010, 29 patients with a bony avulsion of the FDP tendon were treated. The displacement magnitude of the avulsed fragment determined, whether conservative or surgical treatment was performed...
February 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28072735/localized-type-volkmann-s-contracture-treated-with-tendon-transfer-and-tension-reduced-early-mobilization-a-case-report
#16
Yoshio Kaji, Osamu Nakamura, Konosuke Yamaguchi, Sachiko Tobiume, Tetsuji Yamamoto
RATIONALE: For localized type Volkmann's contracture, in which degeneration of the flexor digitorum profundus (FDP) muscle to one or two fingers and restriction of finger extension occur, dissection or excision of the affected muscle is usually recommended. However, these surgical procedures need relatively wide exposure of the muscle, because the FDP muscle is in the deep portion of the forearm. PATIENT CONCERNS: In this report, the case of a 35-year-old woman with localized type Volkmann's contracture is presented...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28069200/effects-of-low-intensity-ultrasound-on-the-growth-cell-membrane-permeability-and-ethanol-tolerance-of-saccharomyces-cerevisiae
#17
Chunhua Dai, Feng Xiong, Ronghai He, Weiwei Zhang, Haile Ma
Effects of low-intensity ultrasound (at different frequency, treatment time and power) on Saccharomyces cerevisiae in different growth phase were evaluated by the biomass in the paper. In addition, the cell membrane permeability and ethanol tolerance of sonicated Saccharomyces cerevisiae were also researched. The results revealed that the biomass of Saccharomyces cerevisiae increased by 127.03% under the optimum ultrasonic conditions such as frequency 28kHz, power 140W/L and ultrasonic time 1h when Saccharomyces cerevisiae cultured to the latent anaphase...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28057800/olefin-isomers-of-a-triazole-bisphosphonate-synergistically-inhibit-geranylgeranyl-diphosphate-synthase
#18
Cheryl Allen, Sandhya Kortagere, Huaxiang Tong, Robert A Matthiesen, Joseph I Metzger, David F Wiemer, Sarah A Holstein
The isoprenoid donor for protein geranylgeranylation reactions, geranylgeranyl diphosphate (GGDP), is the product of the enzyme GGDP synthase (GGDPS) that condenses farnesyl diphosphate (FDP) and isopentenyl pyrophosphate. GGDPS inhibition is of interest from a therapeutic perspective for multiple myeloma because we have shown that targeting Rab GTPase geranylgeranylation impairs monoclonal protein trafficking, leading to endoplasmic reticulum stress and apoptosis. We reported a series of triazole bisphosphonate GGDPS inhibitors, of which the most potent was a 3:1 mixture of homogeranyl (HG) and homoneryl (HN) isomers...
March 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28045196/mechanistic-studies-of-sesquiterpene-cyclases-based-on-their-carbon-isotope-ratios-at-natural-abundance
#19
Wenhua Tan, Stefan Bartram, Wilhelm Boland
During the process of terpene biosynthesis, C-C bond breaking and forming steps are subjected to kinetic carbon isotope effects, leading to distinct carbon isotopic signatures of the products. Accordingly, carbon isotopic signatures could be used to reveal the "biosynthetic history" of the produced terpenoids. Five known sesquiterpene cyclases, regulating three different pathways, representing simple to complex biosynthetic sequences, were heterologously expressed and used for in vitro assays with farnesyl diphosphate as substrate...
January 3, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28041822/effect-of-leukapheresis-on-blood-coagulation-in-patients-with-hyperleukocytic-acute-myeloid-leukemia
#20
Andry Van de Louw
INTRODUCTION: Leukapheresis has been proposed to reduce white blood cell (WBC) count in hyperleukocytic acute myeloid leukemia (AML). However, no survival benefit has been proven and leukapheresis can potentially affect coagulation and worsen bleeding and disseminated intravascular coagulation (DIC). We analyzed the effect of leukapheresis on coagulation tests in a cohort of hyperleukocytic AML patients. METHODS: Retrospective chart review of hyperleukocytic AML patients who underwent leukapheresis between 2003 and 2014...
December 29, 2016: Transfusion and Apheresis Science
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