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https://www.readbyqxmd.com/read/29161233/swimming-but-not-vitamin-e-ameliorates-prothrombotic-state-and-hypofibrinolysis-in-a-rat-model-of-nonalcoholic-fatty-liver-disease
#1
Hussein F Sakr, Amr M Abbas, Mohamed A Haidara
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is associated with a systemic procoagulant hypofibrinolysis state that is considered as a risk factor for microangiopathy and peripheral vascular diseases. Swimming exercise ameliorates the metabolic dysfunction in type 2 diabetes. Vitamin E is a natural antioxidant that reduces the risk of endothelial dysfunction in metabolic syndrome. The aim of the present study is to investigate the effect of combined swimming exercise with vitamin E on coagulation as well as blood fibrinolysis markers in rats with NAFLD...
November 21, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29153952/surveillance-of-the-safety-and-efficacy-of-recombinant-human-soluble-thrombomodulin-in-patients-with-obstetrical-disseminated-intravascular-coagulation
#2
Takao Kobayashi, Masahiro Kajiki, Katsuhito Nihashi, Goichi Honda
BACKGROUND: Recombinant human soluble thrombomodulin (TM-α) has been shown to be useful in the treatment of disseminated intravascular coagulation (DIC) in a heparin-controlled study, and has been available for clinical use in Japan since 2008. However, use of TM-α for obstetrical DIC has not yet been established, so efficacy and safety were analyzed in 117 obstetrical DIC patients identified from post-marketing surveillance. MATERIALS AND METHODS: From June 2010 to March 2012, the cases of 117 patients with obstetrical DIC treated with TM-α were registered...
September 18, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29153748/marginal-discrepancy-of-noble-metal-ceramic-fixed-dental-prosthesis-frameworks-fabricated-by-conventional-and-digital-technologies
#3
Ahmed Afify, Stephan Haney, Ronald Verrett, Michael Mansueto, James Cray, Russell Johnson
STATEMENT OF PROBLEM: Studies evaluating the marginal adaptation of available computer-aided design and computer-aided manufacturing (CAD-CAM) noble alloys for metal-ceramic prostheses are lacking. PURPOSE: The purpose of this in vitro study was to evaluate the vertical marginal adaptation of cast, milled, and direct metal laser sintered (DMLS) noble metal-ceramic 3-unit fixed partial denture (FDP) frameworks before and after fit adjustments. MATERIAL AND METHODS: Two typodont teeth were prepared for metal-ceramic FDP abutments...
November 15, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29143665/cardiopulmonary-and-inflammatory-biomarkers-in-heartworm-disease
#4
REVIEW
Elena Carretón, Rodrigo Morchón, José Alberto Montoya-Alonso
In heartworm disease, several biomarkers of cardiopulmonary injury and inflammatory activity have been studied during the recent years. D-dimer is a fibrin degradation product present after a clot is degraded, which has been reported to provide support for the diagnosis of pulmonary thromboembolism in heartworm disease. Furthermore, concentrations increment with increased disease severity and during the adulticide treatment. This increase in concentration has proved to be valuable. Cardiac biomarkers troponin I, myoglobin and NT-proBNP demonstrated presence of myocardial injury and heart failure, especially in chronic infections, which in some cases, slightly improve after the adulticide treatment...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29142970/cardiovascular-disease-biomarkers-and-supar-in-predicting-decline-in-renal-function-a-prospective-cohort-study
#5
Salim S Hayek, Yi-An Ko, Mosaab Awad, Hina Ahmed, Brandon Gray, Kareem Mohammed Hosny, Hiroshi Aida, Melissa J Tracy, Changli Wei, Sanja Sever, Jochen Reiser, Arshed A Quyyumi
Introduction: Soluble urokinase-type plasminogen activator receptor (suPAR) strongly predicts outcomes and incident chronic kidney disease (CKD) in patients with cardiovascular disease (CVD). Whether the association between suPAR and CKD is a reflection of its overall association with chronic inflammation and poor CVD outcomes is unclear. We examined whether CVD biomarkers, including high-sensitivity C-reactive protein (hs-CRP), fibrin-degradation products (FDPs), heat-shock protein 70 (HSP-70), and high-sensitivity troponin I (hs-TnI) were associated with a decline in kidney function in the Emory Cardiovascular Biobank cohort, in which suPAR levels were shown to be predictive of both incident CKD and CVD outcomes...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29142564/clinical-effects-of-ganglioside-and-fructose-1-6-diphosphate-on-neonatal-heart-and-brain-injuries-after-asphyxia
#6
Xiaojing Zhu, Hongya Li, Congmin Zhang
Objective: To study the clinical effect of ganglioside (GM) and fructose-1, 6-diphosphate (FDP) on neonatal heart and brain injuries after asphyxia. Methods: Ninety-one neonates with asphyxia neonatal heart and brain injuries were randomly divided into an observation group and a control group. Both groups were given symptomatic treatment as soon as possible. On this basis, the observation group was given 200 mL of 5% glucose injection and 20 mg of GM and 250 mg/kg·d FDP by intravenous infusion...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29134355/extracellular-contrast-agent-enhanced-mri-15-min-delayed-phase-may-improve-the-diagnostic-performance-for-hepatocellular-carcinoma-in-patients-with-chronic-liver-disease
#7
Si Eun Lee, Chansik An, Shin Hye Hwang, Jin-Young Choi, Kyunghwa Han, Myeong-Jin Kim
OBJECTIVES: To determine the value of a 15-min delayed phase in extracellular contrast agent (ECA)-enhanced magnetic resonance imaging (MRI) for evaluation of hepatocellular carcinoma (HCC) in patients with chronic liver disease. METHODS: Between 2014 and 2015, 103 patients with chronic liver disease underwent ECA-enhanced MRI; 133 lesions consisting of 107 HCCs, 23 benign lesions and three non-HCC malignancies were identified with pathological or clinical diagnosis...
November 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29132787/distal-biceps-brachii-tendon-transfer-for-re-establishing-extrinsic-finger-function-feasibility-study-in-cadavers
#8
Matthew D Welsch, Alexander D Mih, Brock D Reiter, Gregory A Merrell
PURPOSE: To determine the anatomic feasibility of transferring the biceps brachii tendon into either the extensor digitorum communis (EDC) or flexor digitorum profundus (FDP), determine the excursion imparted to EDC and FDP tendons after transfer, and compare the work capacity of the cadaver biceps to previously published data on the biceps as well as the recipient muscles by calculating the physiologic cross-sectional area (PCSA). METHODS: Four fresh-frozen cadaver shoulder-elbow-wrist specimens were used to measure tendon excursion that can be obtained with transfer of the distal biceps tendon into either the EDC or FDP...
November 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29115742/nucleophilic-water-capture-or-proton-loss-single-amino-acid-switch-converts-delta-cadinene-synthase-to-germacradien-4-ol-synthase
#9
Rudolf K Allemann, Marianna Loizzi, Veronica Gonzalez, David Miller
Delta-Cadinene synthase is a sesquiterpene cyclase that utilizes the universal achiral precursor farnesyl diphosphate (FDP) to generate predominantly the bicyclic sesquiterpene -cadinene and ~2% germacradien-4-ol, which is also generated from FDP by the cyclase germacradien-4-ol synthase. Here, the mechanism, by which sesquiterpene synthases discriminate between deprotonation and reaction with a nucleophilic water molecule was investigated by site directed mutagenesis of -cadinene synthase. When W279 in -cadinene synthase was replaced with various smaller amino acids the ratio of alcohol versus hydrocarbon product was directly proportional to the van der Waals volume of the amino acid side chain...
November 8, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29096812/a-test-in-context-d-dimer
#10
REVIEW
Jeffrey I Weitz, James C Fredenburgh, John W Eikelboom
D-dimer is a soluble fibrin degradation product that results from ordered breakdown of thrombi by the fibrinolytic system. Numerous studies have shown that D-dimer serves as a valuable marker of activation of coagulation and fibrinolysis. Consequently, D-dimer has been extensively investigated for the diagnosis of venous thromboembolism (VTE) and is used routinely for this indication. In addition, D-dimer has been evaluated for determining the optimal duration of anticoagulation in VTE patients, for diagnosing and monitoring disseminated intravascular coagulation, and as an aid in the identification of medical patients at high risk for VTE...
November 7, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29081445/load-bearing-capacity-of-novel-resin-based-fixed-dental-prosthesis-materials
#11
Isil Cekic-Nagas, Ferhan Egilmez, Gulfem Ergun, Pekka Kalevi Vallittu, Lippo Veli Juhana Lassila
To evaluate the influence of different materials on the load-bearing-capacity of inlay-retained fixed-dental-prosthesis (FDP). Ten types of FDPs were evaluated (n=7/group): Group PEEK: CAD-CAM polyetheretherketone (PEEK-TechnoMed), Group RC, made of discontinuous-fiber-composite (EverX Posterior); Group FRC1, made of discontinuous-fiber-composite (EverX Posterior) with two-bundles of continuous-unidirectional fiber-reinforced-composite (FRC) (Everstick C&B); Group FRC2, made of discontinuousfiber-composite (EverX Posterior) with two-bundles of continuous-unidirectional-FRC (Everstick C&B) covered by two-pieces of short-unidirectional-FRC (Everstick C&B) placed perpendicular to the main-framework; Group FB, CAD-CAM fiber-block (FibraComposite Bio-C); Group PMMA, CAD-CAM polymethyl methacrylate block (Temp basic); Group RP, resin-paste; Group FRP1, made of resin-paste (G-Fix) with two-bundles of continuous-unidirectional-FRC (Everstick C&B); Group FRP2, made of resin-paste (G-Fix) two-bundles of continuous-unidirectional-FRC covered by two-pieces of short unidirectional-FRC placed perpendicular to the mainframework and Group exp-FRC, experimental CAD-CAM FRC...
October 27, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/29079186/investigating-the-association-between-african-spontaneously-fermented-dairy-products-faecal-carriage-of-streptococcus-infantarius-subsp-infantarius-and-colorectal-adenocarcinoma-in-kenya
#12
Dasel W M Kaindi, Wambui Kogi-Makau, Godfrey N Lule, Bernd Kreikemeyer, Pierre Renault, Bassirou Bonfoh, Esther Schelling, Jakob Zinsstag, Christophe Lacroix, Leo Meile, Christoph Jans, Jan Hattendorf
Consumption of traditional fermented dairy products (tFDP) in Africa leads to the ingestion of up to 10(8)Streptococcus infantarius subspecies infantarius (Sii) per millilitre of spontaneously fermented milk. Sii is a member of the Streptococcus bovis/Streptococcus equinus complex (SBSEC) for which some members are associated particularly with colorectal cancer or endocarditis. The extent of health risks to tFDP consumers is largely unknown. A hospital-based unmatched case-control study was conducted at Kenyatta National Hospital, Nairobi (Kenya) on 80 cases and 193 controls that were selected exhaustively from patients attending colonoscopy at the hospital...
October 25, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29077164/macrophage-activation-syndrome-as-a-complication-of-juvenile-rheumatoid-arthritis
#13
Q An, M-W Jin, X-J An, S-M Xu, L Wang
OBJECTIVE: Juvenile rheumatoid arthritis (JRA), also known as juvenile idiopathic arthritis (JIA), is a rare autoimmune joint disorder of children. The concrete causes for the prevalence of the above pathological state are still unknown. In other words, it is an arthritis affecting mainly children and adolescents. Clinically, it has 3 different clinical subtypes. JRA patients are often noticed with some confirmed symptoms including coagulopathy, disseminated intravascular coagulation (DIC) with hepatosplenomegaly, fall in erythrocyte sedimentation rate and higher levels of liver enzymes leading to a life-threatening outcome...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29066680/-fresh-frozen-plasma-provides-endothelial-protection-when-administered-early-after-stem-cell-transplantation
#14
Osamu Imataki, Makiko Uemura
BACKGROUND: Veno-occlusive disease(VOD)is a fatal coagulopathy, which is caused by an endothelial disorder among patients who undergo hematopoietic stem cell transplantation(SCT). Some protective agents, such as administration of fresh frozen plasma(FFP), have been evaluated for both prophylactic and targeted therapy. PURPOSE: We evaluated the prophylactic efficacy of FFP for VOD in a retrospective study. METHODS: We surveyed patients who received SCT in our hospital between January 2011 and December 2011...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29062459/comparison-of-the-effects-of-spinal-epidural-and-general-anesthesia-on-coagulation-and-fibrinolysis-in-laparoscopic-cholecystectomy-a-randomized-controlled-trial-vsj-competition-2-nd-place
#15
Suleyman Demiryas, Turgut Donmez, Vuslat Muslu Erdem, Duygu Ayfer Erdem, Engin Hatipoglu, Sina Ferahman, Oguzhan Sunamak, Lale Yoldas Zengin, Ahmet Kocakusak
INTRODUCTION: Laparoscopic cholecystectomy (LC) is usually performed under general anesthesia. Recently, laparoscopic cholecystectomy under regional anesthesia has become popular, but this creates a serious risk of thromboembolism because of pneumoperitoneum, anesthesia technique, operative positioning, and patient-specific risk factors. AIM: This randomized controlled trial compares the effects of two different anesthesia techniques in laparoscopic cholecystectomy on coagulation and fibrinolysis...
September 2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29056863/estimation-of-the-false-discovery-proportion-with-unknown-dependence
#16
Jianqing Fan, Xu Han
Large-scale multiple testing with correlated test statistics arises frequently in many scientific research. Incorporating correlation information in approximating false discovery proportion has attracted increasing attention in recent years. When the covariance matrix of test statistics is known, Fan, Han & Gu (2012) provided an accurate approximation of False Discovery Proportion (FDP) under arbitrary dependence structure and some sparsity assumption. However, the covariance matrix is often unknown in many applications and such dependence information has to be estimated before approximating FDP...
September 2017: Journal of the Royal Statistical Society. Series B, Statistical Methodology
https://www.readbyqxmd.com/read/29056349/clinical-characteristics-of-spontaneous-isolated-visceral-artery-dissection
#17
Yoshihiro Tanaka, Tsuyoshi Yoshimuta, Keiichi Kimura, Kenji Iino, Yudai Tamura, Kenji Sakata, Kenshi Hayashi, Hirofumi Takemura, Masakazu Yamagishi, Masa-Aki Kawashiri
OBJECTIVE: Spontaneous isolated visceral artery dissection (SIVAD) involving the celiac artery or superior mesenteric artery is rare, but it can be fatal. Given its rare incidence, the clinical characteristics of SIVAD are not fully understood. Therefore, the aim of this study was to investigate the clinical characteristics and prognosis of SIVAD. METHODS: We retrospectively reviewed 39 consecutive patients diagnosed with SIVAD from January 2007 to December 2016...
October 19, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29040606/pinopode-score-around-the-time-of-implantation-is-predictive-of-successful-implantation-following-frozen-embryo-transfer-in-hormone-replacement-cycles
#18
X Y Jin, L J Zhao, D H Luo, L Liu, Y D Dai, X X Hu, Y Y Wang, X Lin, F Hong, T C Li, S Y Zhang
STUDY QUESTION: Is pinopode measurement of any prognostic value? SUMMARY ANSWER: Pinopode expression was significantly associated with the occurrence of pregnancy after frozen embryo transfer. WHAT IS KNOWN ALREADY: Pinopodes are expressed in the endometrium during the implantation period. Pinopode measurement has been proposed as a marker of endometrial receptivity. STUDY DESIGN, SIZE, DURATION: A prospective cohort study was conducted at the Center of Reproductive Medicine, Sir Run Run Shaw Hospital, between 2014 and 2016, recruiting 172 women with infertility and undergoing frozen embryo transfer following IVF treatment...
October 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29030123/results-and-complications-of-flexor-digitorum-superficialis-to-profundus-transfer-in-brain-injured-patients-a-review-of-26-patients
#19
E Peraut, L Taïeb, C Jourdan, F Coroian, I Laffont, M Chammas, B Coulet
INTRODUCTION: In hemiplegic patients with a spastic clenched fist deformity, one of the goals of surgery is to address the hygiene, nursing and appearance problems. Transfer of the flexor digitorum superficialis (FDS) to the flexor digitorum profundus (FDP), initially described by Braun and colleagues, opens the non-functional hand in these patients. The primary objective of our study was to confirm the effectiveness of this technique for correcting these deformities. The secondary objectives were to demonstrate potential functional gains and to identify potential complications...
October 10, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28981184/soluble-fibrin-going-for-six
#20
S J Montague
No abstract text is available yet for this article.
October 5, 2017: Journal of Thrombosis and Haemostasis: JTH
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