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Alfred E Pinkney, Mark S Myers, Michael A Rutter
From the 1940s through 1977, at least 590,000kg of polychlorinated biphenyls (PCBs) were released into the Hudson River from General Electric manufacturing plants located in Hudson Falls and Fort Edward, New York. In 1984, the U.S. Environmental Protection Agency designated a nearly 322km reach as the Hudson River PCBs Superfund Site. Here we describe a Fish Health Assessment study, part of a Natural Resource Damage Assessment, that evaluated the prevalence of toxicopathic lesions in adult brown bullhead (Ameiurus nebulosus), smallmouth bass (Micropterus dolomieu), and yellow perch (Perca flavescens)...
October 14, 2016: Science of the Total Environment
José Ramón Corcuera-Flores, Julián López-Giménez, Julián López-Jiménez, Ana López-Giménez, Javier Silvestre-Rangil, Guillermo Machuca-Portillo
OBJECTIVES: To evaluate implant survival rate and marginal bone loss (MBL) after 4 years in patients with Down syndrome and cerebral palsy, compared with a healthy control group. MATERIAL AND METHODS: The case group comprises 102 implants in 19 patients (71 cerebral palsy, 21 Down syndrome), and the control group comprises 70 implants in 22 healthy patients. One implant per patient was selected (n = 41 implants) to take clustering effects into account. MBL was measured using two panoramic radiographs (after surgery and 4 years later)...
October 14, 2016: Clinical Oral Investigations
Célia V Romão, João B Vicente, Patrícia T Borges, Bruno L Victor, Pedro Lamosa, Elisio Silva, Luís Pereira, Tiago M Bandeiras, Cláudio M Soares, Maria A Carrondo, David Turner, Miguel Teixeira, Carlos Frazão
Flavodiiron proteins (FDPs) are present in organisms from all domains of life and have been described so far to be involved in the detoxification of oxygen or nitric oxide, acting as O2 and/or NO reductases. The Escherichia coli FDP, named flavorubredoxin (FlRd) is the most extensively studied FDP. Biochemical and in vivo studies revealed that FlRd is involved in NO detoxification, as part of the bacterial defense mechanisms against reactive nitrogen species. E. coli FlRd has a clear preference for NO as substrate in vitro, exhibiting a very low reactivity towards O2...
October 7, 2016: Journal of Molecular Biology
Evren Yaşar, Emre Adigüzel, Serdar Kesikburun, Itır Yenihayat, Bilge Yılmaz, Rıdvan Alaca, Arif Kenan Tan
OBJECTIVES: Here we aimed to investigate the feasibility of sonoelastography to show muscle stiffness in post-stroke spasticity, and the relationship between sonoelastography findings and clinical spasticity scores in the spastic forearm muscles. METHODS: This study was carried out in a university rehabilitation center. 26 stroke patients with forearm muscle spasticity (≥ 1+ using the Modified Ashworth Scale score and ≥1 using the Tardieu scale) were included...
September 28, 2016: British Journal of Radiology
Anna Gabriella Camacho Presotto, Cláudia Lopes Brilhante Bhering, Marcelo Ferraz Mesquita, Valentim Adelino Ricardo Barão
STATEMENT OF PROBLEM: Several studies have shown the superiority of computer-assisted design and computer-assisted manufacturing (CAD-CAM) technology compared with conventional casting. However, an advanced technology exists for casting procedures (the overcasting technique), which may serve as an acceptable and affordable alternative to CAD-CAM technology for fabricating 3-unit implant-supported fixed dental prostheses (FDPs). PURPOSE: The purpose of this in vitro study was to evaluate, using quantitative photoelastic analysis, the effect of the prosthetic framework fabrication method (CAD-CAM and overcasting) on the marginal fit and stress transmitted to implants...
September 22, 2016: Journal of Prosthetic Dentistry
Luciana Galetto, Dimitrios E Miliordos, Mattia Pegoraro, Dario Sacco, Flavio Veratti, Cristina Marzachì, Domenico Bosco
Flavescence dorée (FD) is a threat for wine production in the vineyard landscape of Piemonte, Langhe-Roero and Monferrato, Italy. Spread of the disease is dependent on complex interactions between insect, plant and phytoplasma. In the Piemonte region, wine production is based on local cultivars. The role of six local grapevine varieties as a source of inoculum for the vector Scaphoideus titanus was investigated. FD phytoplasma (FDP) load was compared among red and white varieties with different susceptibility to FD...
2016: International Journal of Molecular Sciences
Marco Guidi, Cesare Fusetti, Stefano Lucchina
Urothelial cell carcinoma (UCC) metastases to skeletal muscle are extremely rare and usually found in patients with advanced stage cancer. The most common sites of bladder cancer metastases are lymph nodes, lung, liver, and bones. Muscle is an unusual site of metastases from a distant primary cancer, due to several protective factors. We present a rare case of 76-year-old patient with metastases in the flexor digitorum superficialis (FDS) and flexor digitorum profundus (FDP) muscles, 2 years after a radical cystectomy for invasive UCC of the bladder...
2016: Case Reports in Urology
Benjamin Jacobs, Andrea Obi, Thomas Wakefield
OBJECTIVE: Venous thromboembolism (VTE) is a common disease with serious, often fatal sequelae. The optimal strategy for diagnosis of VTE remains unclear, although considerable progress has been made in this area. Several new biomarkers have showed promise for diagnosis of VTE, and more are under active investigation. We reviewed the literature for studies evaluating these diagnostic biomarkers. METHODS: We reviewed the English literature between 1990 and 2015, searching for papers evaluating diagnostic performance of biomarkers in VTE...
October 2016: Journal of Vascular Surgery. Venous and Lymphatic Disorders
Prabhat Kumar, Riyaz Charaniya, Anish Bahl, Anindya Ghosh, Juhi Dixit
Facial nerve palsy (FNP) is a common medical problem and can be unilateral or bilateral. Unilateral facial palsy has an incidence of 25 per 100,000 population and most of them are idiopathic. However, facial diplegia or bilateral facial nerve palsy (B-FNP) is rare with an incidence of just 1 per 5,000,000 population and only 20 percent cases are idiopathic. Facial diplegia is said to be simultaneous if the other side is affected within 30 days of involvement of first side. Guillain-Barre Syndrome (GBS) is a common cause of facial diplegia and almost half of these patients have facial nerve involvement during their illness...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Rosemary E McDowell, Mary K McGahon, Josy Augustine, Mei Chen, J Graham McGeown, Tim M Curtis
PURPOSE: We studied whether the accumulation of advanced lipoxidation end-products (ALEs) in the diabetic retina is linked to the impairment of lipid aldehyde detoxification mechanisms. METHODS: Retinas were collected from nondiabetic and diabetic rats and processed for conventional and quantitative RT-PCR (qRT-PCR), Western blotting, immunohistochemistry, and aldehyde dehydrogenase (ALDH) activity assays. The effect of the ALDH1a1 inhibitor, NCT-501, on ALE accumulation and cell viability in cultured Müller glia also was investigated...
September 1, 2016: Investigative Ophthalmology & Visual Science
Maj H Nicolaisen, Golnosh Bahrami, Lars Schropp, Flemming Isidor
PURPOSE: The aim of this study was to assess functional and esthetic satisfaction plus evaluate changes in oral health-related quality of life (OHRQoL) using the Oral Health Impact Profile (OHIP-14) after insertion of a metal-ceramic (MC-FDP) or a veneered zirconia all-ceramic (AC-FDP) posterior three-unit fixed dental prosthesis (FDP). Additionally, patients' and professionals' esthetic evaluations were compared. MATERIALS AND METHODS: A convenience sample of 34 patients was randomized to receive a MC-FDP (n = 17) or an AC-FDP (n = 17)...
September 2016: International Journal of Prosthodontics
Bhavik Mehta, Runa Daniel, Chris Phillips, Stephen Doyle, Gareth Elvidge, Dennis McNevin
Forensic DNA based intelligence, or Forensic DNA Phenotyping (FDP), utilises single nucleotide polymorphisms (SNPs) to infer the biogeographical ancestry (BGA) and externally visible characteristics (EVCs) of the donor of evidential material. SNaPshot(®) is a commonly employed forensic SNP genotyping technique which is limited to multiplexes of 30-40 SNPs in a single reaction and prone to PCR contamination. Massively parallel sequencing (MPS) has the ability to genotype hundreds of SNPs in multiple samples simultaneously by employing an oligonucleotide sample barcoding strategy...
September 8, 2016: Electrophoresis
Esben Boeskov Øzhayat, Peter Østergaard, Klaus Gotfredsen
OBJECTIVE: The aims of this study were to investigate and describe the Oral Health Related Quality of Life (OHRQoL) in a socially endangered group of people and to compare the OHRQoL to other patient groups. MATERIAL AND METHODS: About 294 socially endangered persons attending a volunteer clinic in Copenhagen Denmark filled in the OHIP-14 questionnaire. The group was compared in mean score and reported problems to a group of patients with tooth loss and about to have a removable dental prosthesis (RDP), a group with tooth loss about to have a fixed dental prosthesis (FDP) and a control group without tooth loss...
September 7, 2016: Acta Odontologica Scandinavica
Mian Chee Gor, Nitin Mantri, Edwin Pang
A Fragaria Discovery Panel (FDP; strawberry-specific SDA) containing 287 features was constructed by subtracting the pooled gDNA of nine non-angiosperm species from the pooled gDNA of five strawberry genotypes. This FDP was used for Bulk Segregant Analysis (BSA) to enable identification of molecular markers associated with day-neutrality. Analysis of hybridisation patterns of a short day (SD) DNA bulk and three day-neutral (DN) DNA bulks varying in flowering strength allowed identification of a novel feature, FaP2E11, closely linked to CYTOKININ OXIDASE 1 (CKX1) gene possibly involved in promoting flowering under non-inductive condition...
2016: Scientific Reports
Huan-Huan Qi, Jun Bao, Qi Zhang, Bo Ma, Gui-Ying Gu, Peng-Ling Zhang, Gang Ou-Yang, Zi-Mei Wu, Han-Jie Ying, Ping-Kai Ou-Yang
Strontium fructose 1,6-diphosphate (FDP-Sr) is a new strontium-containing compound. The primary aim of this study was to clarify whether the structure component of FDP-Sr, FDP could benefit the protective effect of Sr (II) against oxidative stress induced apoptosis, and meanwhile to further explore the important role of Wnt/β-catenin signaling in the anti-apoptosis effect of FDP-Sr in response to oxidative stress induced by H2O2 in an osteoblastic MC3T3-E1 cell line. Results showed that FDP-Sr could improve the osteoblastic differentiation under oxidative stress with induced cell proliferation and improved mineralization...
October 1, 2016: Bioorganic & Medicinal Chemistry Letters
Wolfgang Bömicke, Stefan Rues, Verena Hlavacek, Peter Rammelsberg, Marc Schmitter
OBJECTIVES: To compare ultimate fracture load (Fu ), load at first damage (F1d ), and fracture pattern for posterior fixed dental prostheses (FDPs) manufactured from translucent, yttria-stabilized zirconia polycrystal. METHODS: Premolar-size FDPs in 4 test groups (n = 16/group) were constructed as veneered complete crown-retained (group 1), monolithic complete crown-retained (group 2), monolithic partial veneer crown-retained (group 3), or monolithic resin-bonded (group 4) prostheses with minimum zirconia wall thickness (0...
August 26, 2016: Journal of Esthetic and Restorative Dentistry
Mustafa Gazi Uçar, Tolgay Tuyan İlhan, Rahime Merve Uçar, Pinar Karabağli, Çetin Çelik
OBJECTIVES: This study reviews occasions when cervical polyps removed in an outpatient setting proved not to be cervical polyps histologically. We aimed to identify any anatomical and/or clinical characteristics that predict 'incorrect diagnosis" in general practice. METHODS: A retrospective study of consecutive 345 patients who were initially diagnosed with cervical polyps based on a routine gynecological examination in an outpatient setting was included. After histopathological examination, the patients were divided into 2 groups: those with cervical (correct diagnosis, n = 307) and falsely diagnosed with cervical polyps (FDP, n = 38)...
October 2016: Journal of Lower Genital Tract Disease
Tai-Hua Yang, Szu-Ching Lu, Wei-Jr Lin, Kristin Zhao, Chunfeng Zhao, Kai-Nan An, I-Ming Jou, Pei-Yuan Lee, Li-Chieh Kuo, Fong-Chin Su
BACKGROUND: The flexor digitorum superficialis (FDS) and flexor digitorum profundus (FDP) are critical for finger flexion. Although research has recently focused on these tendons' coactivity, their contributions in different tasks remain unclear. This study created a novel simultaneous approach to investigate the coactivity between the tendons and to clarify their contributions in different tasks. METHODS: Ten human cadaveric hands were mounted on our custom frame with the FDS and FDP of the third finger looped through a mechanical pulley connected to a force transducer...
2016: PloS One
Kenichiro Uchida, Mitsuharu Hosono, Toshihiko Shibata, Daisuke Kaku, Tomonori Yamamoto, Takafumi Terada, Naoki Shinyama, Yasumitsu Mizobata
BACKGROUND: Mobile intra-aortic thrombus without atherosclerosis, aneurysm, or congenital coagulopathy is very rare, and there are few reports especially in young or middle-aged patients. Furthermore, there are presently no established guidelines or common strategies for the treatment of mobile intra-aortic thrombus. In this case report, we describe the first case of intra-aortic thrombus caused by secondary erythrocytosis and describe the recommended treatment strategy for intra-aortic thrombus...
2016: Journal of Medical Case Reports
Hiroyuki Koami, Yuichiro Sakamoto, Ryota Sakurai, Miho Ohta, Hisashi Imahase, Mayuko Yahata, Mitsuru Umeka, Toru Miike, Futoshi Nagashima, Takashi Iwamura, Kosuke Chris Yamada, Satoshi Inoue
The aim of this study is to evaluate the hematological differences between septic and traumatic disseminated intravascular coagulation (DIC) using the rotational thromboelastometry (ROTEM).This retrospective study includes all sepsis or severe trauma patients transported to our emergency department who underwent ROTEM from 2013 to 2014. All patients were divided into 2 groups based on the presence of DIC diagnosed by the Japanese Association for Acute Medicine (JAAM) DIC score. We statistically analyzed the demographics, clinical characteristics, laboratory data, ROTEM findings (EXTEM and FIBTEM), and outcome...
August 2016: Medicine (Baltimore)
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