Huan Yang, Xiaoxiao Wu, Xiao Li, Wanqing Zang, Zhou Zhou, Yuan Zhou, Wenwen Cui, Yanbo Kou, Liang Wang, Ankang Hu, Lianlian Wu, Zhinan Yin, Quangang Chen, Ying Chen, Zhutao Huang, Yugang Wang, Bing Gu
Antibiotic-induced dysbiosis is a major risk factor for Clostridioides difficile infection (CDI), and fecal microbiota transplantation (FMT) is recommended for treating CDI. However, the underlying mechanisms remain unclear. Here, we show that Tritrichomonas musculis (T.mu), an integral member of the mouse gut commensal microbiota, reduces CDI-induced intestinal damage by inhibiting neutrophil recruitment and IL-1β secretion, while promoting Th1 cell differentiation and IFN-γ secretion, which in turn enhances goblet cell production and mucin secretion to protect the intestinal mucosa...
April 2, 2024: Nature Communications