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https://www.readbyqxmd.com/read/28087657/european-consensus-conference-on-faecal-microbiota-transplantation-in-clinical-practice
#1
Giovanni Cammarota, Gianluca Ianiro, Herbert Tilg, Mirjana Rajilić-Stojanović, Patrizia Kump, Reetta Satokari, Harry Sokol, Perttu Arkkila, Cristina Pintus, Ailsa Hart, Jonathan Segal, Marina Aloi, Luca Masucci, Antonio Molinaro, Franco Scaldaferri, Giovanni Gasbarrini, Antonio Lopez-Sanroman, Alexander Link, Pieter de Groot, Willem M de Vos, Christoph Högenauer, Peter Malfertheiner, Eero Mattila, Tomica Milosavljević, Max Nieuwdorp, Maurizio Sanguinetti, Magnus Simren, Antonio Gasbarrini
Faecal microbiota transplantation (FMT) is an important therapeutic option for Clostridium difficile infection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with the alteration of gut microbiota. Although the health community is assessing FMT with renewed interest and patients are becoming more aware, there are technical and logistical issues in establishing such a non-standardised treatment into the clinical practice with safety and proper governance...
January 13, 2017: Gut
https://www.readbyqxmd.com/read/28068651/comparison-of-alternative-coupling-methods-of-the-vibrant-soundbridge-floating-mass-transducer
#2
Susan Busch, Thomas Lenarz, Hannes Maier
The active middle ear implant Vibrant Soundbridge© provides a variety of coupling modalities of the floating mass transducer (FMT) to various structures of the ossicular chain and the round window. A retrospective analysis was performed on 125 subjects (n = 137 ears) (1) to compare the efficacy of the different FMT coupling modalities with increasing degree of hearing loss, (2) to compare the performance in speech outcome and the effective gain between the coupling types, and (3) to evaluate the risk of additional hearing loss of each coupling procedure...
January 10, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28059612/fecal-microbial-transplantation-as-a-therapeutic-option-in-patients-colonized-with-antibiotic-resistant-organisms
#3
Michael Laffin, Braden Millan, Karen L Madsen
Despite increasing interest in fecal microbiota transplantation (FMT), its full therapeutic potential has yet to be determined. Since its increase in popularity, FMT has been shown to be highly effective in the treatment of both Clostridium difficile infection (CDI) and its recurrent form. Interest in FMT now expands well beyond the treatment of CDI to other processes with known associations to the microbiota such as antibiotic resistant infections, inflammatory bowel disease (IBD), hepatic encephalopathy, neuropsychiatric disorders, and metabolic disease...
January 6, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28058011/fecal-microbial-transplant-for-the-treatment-of-pediatric-inflammatory-bowel-disease
#4
REVIEW
Alice Yuxin Wang, Jelena Popov, Nikhil Pai
The role of fecal microbial transplant (FMT) in the treatment of pediatric gastrointestinal disease has become increasingly popular among pediatric practitioners, patients, and parents. The success of FMT for the treatment of recurrent Clostridium difficile infection (RCDI) has bolstered interest in its potential application to other disease states, such as inflammatory bowel disease (IBD). FMT has particular interest in pediatrics, given the concerns of patients and parents about rates of adverse events with existing therapeutic options, and the greater cumulative medication burden associated with childhood-onset disease...
December 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28057560/predictors-of-failure-after-single-faecal-microbiota-transplantation-in-patients-with-recurrent-clostridium-difficile-infection-results-from-a-three-year-single-centre-cohort-study
#5
Gianluca Ianiro, Luca Valerio, Luca Masucci, Silvia Pecere, Stefano Bibbò, Gianluca Quaranta, Brunella Posteraro, Diego Currò, Maurizio Sanguinetti, Antonio Gasbarrini, Giovanni Cammarota
OBJECTIVES: Faecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridium difficile infection (CDI). Although a single faecal infusion is usually sufficient to eradicate CDI, a considerable rate of patients needs multiple infusions to be cured. The aim of this study was to identify predictors of failure after single faecal infusion in patients with recurrent CDI. METHODS: We included patients with recurrent CDI prospectively treated with FMT by colonoscopy...
January 2, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28042242/perceptions-of-fecal-microbiota-transplantation-for-clostridium-difficile-infection-factors-that-predict-acceptance
#6
Leslie Park, Anjali Mone, Jennifer C Price, Demetrios Tzimas, Jacqueline Hirsh, Michael A Poles, Lisa Malter, Lea Ann Chen
BACKGROUND: Despite the effectiveness of fecal microbiota transplantation (FMT) for treating recurrent Clostridium difficile (C. difficile) infection, some patients are reluctant to accept this therapy. Our study examined attitudes towards FMT and factors that contribute to patients' acceptance of this treatment. METHODS: We distributed patient surveys at a Veterans Affairs hospital, a public hospital, and an academic faculty practice. Multivariable logistic regression was performed, adjusting for factors associated with FMT acceptance on univariate analysis and prior experience with C...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28039159/gut-microbiota-differs-between-children-with-inflammatory-bowel-disease-and-healthy-siblings-in-taxonomic-and-functional-composition-a-metagenomic-analysis
#7
Rebecca Luise Knoll, Kristoffer Forslund, Jens Roat Kultima, Claudius U Meyer, Ulrike Kullmer, Shinichi Sunagawa, Peer Bork, Stephan Gehring
Current treatment for pediatric IBD patients is often ineffective, with serious side effects. Manipulating the gut microbiota via fecal microbiota transplantation (FMT) is an emerging treatment approach but remains controversial. We aimed to assess the composition of the fecal microbiome through a comparison of pediatric IBD patients to their healthy siblings, evaluating risks and prospects for FMT in this setting. A Case-Control (Sibling) Study was conducted analyzing fecal samples of six children with Crohn's Disease (CD), six children with Ulcerative Colitis (UC) and 12 healthy siblings by metagenomic sequencing...
December 30, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28018722/automatic-selection-of-regularization-parameters-for-dynamic-fluorescence-molecular-tomography-a-comparison-of-l-curve-and-u-curve-methods
#8
Maomao Chen, Han Su, Yuan Zhou, Chuangjian Cai, Dong Zhang, Jianwen Luo
Dynamic fluorescence molecular tomography (FMT) is a promising technique for the study of the metabolic process of fluorescent agents in the biological body in vivo, and the quality of the parametric images relies heavily on the accuracy of the reconstructed FMT images. In typical dynamic FMT implementations, the imaged object is continuously monitored for more than 50 minutes. During each minute, a set of the fluorescent measurements is acquired and the corresponding FMT image is reconstructed. It is difficult to manually set the regularization parameter in the reconstruction of each FMT image...
December 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/28012324/image-guided-implantation-of-the-bonebridge%C3%A2-with-a-surgical-navigation-a-feasibility-study
#9
Tae Hoon Kong, Yoon Ah Park, Young Joon Seo
OBJECTIVE: To access a method of fitting a designated location on the patient's temporal bone by surgically navigating to the Bonebridge implantation. STUDY DESIGN: A patient with unilateral profound hearing loss received early intervention with the Bonebridge implant for binaural hearing. The optimal implant site was determined from computed tomography (CT) images using a three-dimensional (3D) simulation software program before the surgery. The pre-calculated coordinates from the 3D simulation software program were moved to the Scopis Hybrid Navigation System...
November 30, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28001467/fecal-microbiota-transplant-in-severe-and-severe-complicated-clostridium-difficile-a-promising-treatment-approach
#10
Monika Fischer, Brian Sipe, Yao-Wen Cheng, Emmalee Phelps, Nicholas Rogers, Sashidhar Sagi, Matthew Bohm, Huiping Xu, Zain Kassam
Severe and severe-complicated Clostridium difficile infection (CDI) is associated with high morbidity and mortality. Colectomy is standard of care; however, post-operative mortality rates approach 50%. Case reports suggest fecal microbiota transplant (FMT) is a promising treatment for severe and severe-complicated disease but there is a paucity of data. Here, we present a single center experience with a novel sequential FMT protocol for patients refractory to maximal medical therapy. This approach consists of at least one FMT delivered via colonoscopy with criteria for repeat FMT and continued vancomycin therapy based on clinical response and pseudomembranes...
December 21, 2016: Gut Microbes
https://www.readbyqxmd.com/read/28000190/-short-term-efficacy-on-fecal-microbiota-transplantation-combined-with-soluble-dietary-fiber-and-probiotics-in-the-treatment-of-slow-transit-constipation
#11
Xiaolong Ge, Chao Ding, Jianfeng Gong, Hongliang Tian, Yao Wei, Qiyi Chen, Lili Gu, Ning Li
OBJECTIVE: To evaluate the efficacy and safety of fecal microbiota transplantation (FMT) combined with soluble dietary fiber and probiotics for slow transit constipation(STC). METHODS: Twenty-three patients with STC from Jinling Hospital, Medical School of Nanjing University were prospectively enrolled between April 2015 and January 2016. STC patients received FMT combined with soluble dietary fiber and probiotics. Fresh stool(100 g) was immediately mixed in a blender with 500 ml of 0...
December 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27999796/a-sparsity-constrained-preconditioned-kaczmarz-reconstruction-method-for-fluorescence-molecular-tomography
#12
Duofan Chen, Jimin Liang, Yao Li, Guanghui Qiu
Fluorescence molecular tomography (FMT) is an imaging technique that can localize and quantify fluorescent markers to resolve biological processes at molecular and cellular levels. Owing to a limited number of measurements and a large number of unknowns as well as the diffusive transport of photons in biological tissues, the inverse problem in FMT is usually highly ill-posed. In this work, a sparsity-constrained preconditioned Kaczmarz (SCP-Kaczmarz) method is proposed to reconstruct the fluorescent target for FMT...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27999162/complete-microbiota-engraftment-is-not-essential-for-recovery-from-recurrent-clostridium-difficile-infection-following-fecal-microbiota-transplantation
#13
Christopher Staley, Colleen R Kelly, Lawrence J Brandt, Alexander Khoruts, Michael J Sadowsky
: Bacterial communities from subjects treated for recurrent Clostridium difficile infection (rCDI) by fecal microbiota transplantation (FMT), using either heterologous donor stool samples or autologous stool samples, were characterized by Illumina next-generation sequencing. As previously reported, the success of heterologous FMT (90%) was superior to that of autologous FMT (43%) (P = 0.019), and post-FMT intestinal bacterial communities differed significantly between treatment arms (P < 0...
December 20, 2016: MBio
https://www.readbyqxmd.com/read/27999027/gut-sparing-treatment-of-urinary-tract-infection-in-patients-at-high-risk-of-clostridium-difficile-infection
#14
Christopher Staley, Byron P Vaughn, Carolyn T Graiziger, Michael J Sadowsky, Alexander Khoruts
BACKGROUND: Recipients of faecal microbiota transplantation (FMT) in treatment of recurrent Clostridium difficile infection (RCDI) remain at markedly increased risk of re-infection with C. difficile with new antibiotic provocations. Urinary tract infections (UTIs) are common indications for antibiotics in these patients, often resulting in C. difficile re-infection. METHODS: We present a case series of 19 patients treated with parenteral aminoglycosides for UTI following FMT for RCDI...
December 20, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27984397/donor-screening-experience-for-fecal-microbiota-transplantation-in-patients-with-recurrent-c-difficile-infection
#15
Raseen Tariq, Renee Weatherly, Patricia Kammer, Darrell S Pardi, Sahil Khanna
GOALS: To evaluate our experience with stool donor recruitment, screening, retention, and donor perception for fecal microbiota transplantation (FMT). BACKGROUND: Multiply recurrent Clostridium difficile infection is being increasingly managed with FMT from donor stools. However, donor selection and recruitment is challenging due to lack of standard evidence-based guidelines, donor exclusion criteria, frequency of screening and donor commitment. METHODS: Data on donors screened using institutional guidelines with history, blood and stool testing and their perspectives on donation were analyzed...
December 14, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27983482/lack-of-formylated-methionyl-trna-has-pleiotropic-effects-on-bacillus-subtilis
#16
Yanfei Cai, Pete Chandrangsu, Ahmed Gaballa, John D Helmann
Bacteria initiate translation using a modified amino acid, N-formylmethionine (fMet), adapted specifically for this function. Most proteins are processed co-translationally by peptide deformylase (PDF) to remove this modification. Although PDF activity is essential in wild-type cells, and is the target of the antibiotic actinonin, bypass mutations in the fmt gene that eliminate the formylation of Met-tRNAMet render PDF dispensable. The extent to which the emergence of fmt bypass mutations might compromise the therapeutic utility of actinonin is determined, in part, by the effects of these bypass mutations on fitness...
December 15, 2016: Microbiology
https://www.readbyqxmd.com/read/27940248/integrin-targeted-hybrid-fluorescence-molecular-tomography-x-ray-computed-tomography-for-imaging-tumor-progression-and-early-response-in-non-small-cell-lung-cancer
#17
Xiaopeng Ma, Valerie Phi Van, Melanie A Kimm, Jaya Prakash, Horst Kessler, Katja Kosanke, Annette Feuchtinger, Michaela Aichler, Aayush Gupta, Ernst J Rummeny, Michel Eisenblätter, Jens Siveke, Axel K Walch, Rickmer Braren, Vasilis Ntziachristos, Moritz Wildgruber
Integrins play an important role in tumor progression, invasion and metastasis. Therefore we aimed to evaluate a preclinical imaging approach applying ανβ3 integrin targeted hybrid Fluorescence Molecular Tomography/X-ray Computed Tomography (FMT-XCT) for monitoring tumor progression as well as early therapy response in a syngeneic murine Non-Small Cell Lung Cancer (NSCLC) model. Lewis Lung Carcinomas were grown orthotopically in C57BL/6 J mice and imaged in-vivo using a ανβ3 targeted near-infrared fluorescence (NIRF) probe...
December 7, 2016: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/27935413/stable-core-virome-despite-variable-microbiome-after-fecal-transfer
#18
Felix Broecker, Giancarlo Russo, Jochen Klumpp, Karin Moelling
We recently described the 4.5-year time course of the enteric bacterial microbiota and virome of a patient cured from recurrent Clostridium difficile infection (rCDI) by fecal microbiota transplantation (FMT). Here, we extended the virome analyses and found the patient's phage population to exhibit highly donor-similar characteristics following FMT, which remained stable for the whole period tested (up to 7 months). Moreover, the detected viral populations of donor and patient exhibited comparable diversity and richness...
December 9, 2016: Gut Microbes
https://www.readbyqxmd.com/read/27929078/gut-microbiota-from-metabolic-disease-resistant-macrophage-specific-rip140-knockdown-mice-improves-metabolic-phenotype-and-gastrointestinal-integrity
#19
Yi-Wei Lin, Emmanuel Montassier, Dan Knights, Li-Na Wei
While fecal microbiota transplantation (FMT) presents an attractive therapeutic strategy, it remains unclear how to choose the microbiota repertoire that most effectively transfers benefit to recipients. We identified a beneficial taxonomic repertoire in a transgenic mouse model (RIP140mϕKD) which resists the development of high fat diet (HFD)-induced metabolic diseases due to enhanced anti-inflammation engineered by lowering receptor interacting protein (RIP140) expression in macrophage. We confirmed using FMT from HFD-fed RIP140mϕKD to wild type (WT) mice that recipient mice acquired the microbiota repertoire of donor mice...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27916451/progressive-development-of-endometriosis-and-its-hindrance-by-anti-platelet-treatment-in-mice-with-induced-endometriosis
#20
Qi Zhang, Xishi Liu, Sun-Wei Guo
We have recently shown that platelets drive smooth muscle metaplasia (SMM) and fibrogenesis in endometriosis through epithelial-mesenchymal transition (EMT) and fibroblast-to-myofibroblast transdifferentiation (FMT). To see whether this is true in vivo, this prospective, randomized, and serially evaluated mouse investigation was conducted. Endometriosis was induced in female Balb/C mice, which were then randomly divided into two groups: Tanshinone IIA (TAN) and control (CTL) groups. TAN mice were treated with TAN but CTL mice received none...
November 21, 2016: Reproductive Biomedicine Online
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