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https://www.readbyqxmd.com/read/27895993/non-stationary-reconstruction-for-dynamic-fluorescence-molecular-tomography-with-extended-kalman-filter
#1
Xin Liu, Hongkai Wang, Zhuangzhi Yan
Dynamic fluorescence molecular tomography (FMT) plays an important role in drug delivery research. However, the majority of current reconstruction methods focus on solving the stationary FMT problems. If the stationary reconstruction methods are applied to the time-varying fluorescence measurements, the reconstructed results may suffer from a high level of artifacts. In addition, based on the stationary methods, only one tomographic image can be obtained after scanning one circle projection data. As a result, the movement of fluorophore in imaged object may not be detected due to the relative long data acquisition time (typically >1 min)...
November 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27893543/changes-in-intestinal-microbiota-following-combination-therapy-with-fecal-microbial-transplantation-and-antibiotics-for-ulcerative-colitis
#2
Dai Ishikawa, Takashi Sasaki, Taro Osada, Kyoko Kuwahara-Arai, Keiichi Haga, Tomoyoshi Shibuya, Keiichi Hiramatsu, Sumio Watanabe
BACKGROUND: Fecal microbiota transplantation (FMT) is a potential therapeutic approach to restore normal intestinal microbiota in patients with ulcerative colitis (UC), which is associated with dysbiosis; however, treatment efficacy remains unclear. Hence, we studied the impact of antibiotic pretreatment with amoxicillin, fosfomycin, and metronidazole (AFM therapy) and FMT versus AFM alone. METHODS: AFM therapy was administered to patients for 2 weeks until 2 days before FMT...
November 22, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27891639/consensus-report-faecal-microbiota-transfer-clinical-applications-and-procedures
#3
REVIEW
J König, A Siebenhaar, C Högenauer, P Arkkila, M Nieuwdorp, T Norén, C Y Ponsioen, U Rosien, N G Rossen, R Satokari, A Stallmach, W de Vos, J Keller, R J Brummer
BACKGROUND: Faecal microbiota transplantation or transfer (FMT) aims at replacing or reinforcing the gut microbiota of a patient with the microbiota from a healthy donor. Not many controlled or randomised studies have been published evaluating the use of FMT for other diseases than Clostridium difficile infection, making it difficult for clinicians to decide on a suitable indication. AIM: To provide an expert consensus on current clinical indications, applications and methodological aspects of FMT...
November 27, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27881135/cat-s-whiskers-orthosiphon-stamineus-tea-modulates-arthritis-pathogenesis-via-the-angiogenesis-and-inflammatory-cascade
#4
Yasser M Tabana, Fouad Saleih R Al-Suede, Mohamed B Khadeer Ahamed, Saad S Dahham, Loiy E Ahmed Hassan, Saba Khalilpour, Mohamad Taleb-Agha, Doblin Sandai, Aman S Abdul Majid, Amin Malik Shah Abdul Majid
BACKGROUND: Orthosiphon stamineus is used traditionally to treat gout, arthritis, and inflammatory related conditions. The in vitro anti-inflammatory effects of the plant have been scientifically investigated. The goal of the present study was to evaluate the potential of the 50% ethanol extract of O. stamineus (EOS) to treat rheumatoid arthritis. METHODS: Anti-arthritic activity was assessed using the in vitro heat denaturation test and the (FCA)-induced arthritis model...
November 24, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27879485/patients-views-on-fecal-microbiota-transplantation-an-acceptable-therapeutic-option-in-inflammatory-bowel-disease
#5
Jonas Zeitz, Marina Bissig, Christiane Barthel, Luc Biedermann, Sylvie Scharl, Daniel Pohl, Pascal Frei, Stephan R Vavricka, Michael Fried, Gerhard Rogler, Michael Scharl
BACKGROUND: Fecal microbiota transplantation (FMT) represents a new therapeutic option that has been studied in two randomized-controlled trials in ulcerative colitis patients. Our study aimed to identify patients' views on the use of this novel therapeutic approach. METHODS: Using an anonymous questionnaire, we obtained data from 574 inflammatory bowel disease (IBD) patients on their knowledge and willingness to undergo FMT. RESULTS: A large proportion of IBD patients (53...
November 22, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27868394/sensitivity-and-accuracy-of-hybrid-fluorescence-mediated-tomography-in-deep-tissue-regions
#6
Stefanie Rosenhain, Wa'el Al Rawashdeh, Fabian Kiessling, Felix Gremse
Fluorescence-mediated tomography (FMT) enables noninvasive assessment of the three-dimensional distribution of near-infrared fluorescence in mice. The combination with micro-computed tomography (µCT) provides anatomical data, enabling improved fluorescence reconstruction and image analysis. The aim of our study was to assess sensitivity and accuracy of µCT-FMT under realistic in vivo conditions in deeply-seated regions. Accordingly, we acquired fluorescence reflectance images (FRI) and µCT-FMT scans of mice which were prepared with rectal insertions with different amounts of fluorescent dye...
November 21, 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/27866880/efficacy-of-sterile-fecal-filtrate-transfer-for-treating-patients-with-clostridium-difficile-infection
#7
Stephan J Ott, Georg H Waetzig, Ateequr Rehman, Jacqueline Moltzau-Anderson, Richa Bharti, Juris A Grasis, Liam Cassidy, Andreas Tholey, Helmut Fickenscher, Dirk Seegert, Philip Rosenstiel, Stefan Schreiber
BACKGROUND & AIMS: Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridium difficile infection (CDI). However, transferring undefined living bacteria entails uncontrollable risks for infectious and metabolic or malignant diseases, particularly in immunocompromised patients. We investigated whether sterile fecal filtrates (containing bacterial debris, proteins, antimicrobial compounds, metabolic products and oligonucleotides/DNA), rather than intact microorganisms, are effective in patients with CDI...
November 17, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27860393/dura-and-sinus-compression-with-a-transcutaneous-bone-conduction-device-hearing-outcomes-and-safety-in-38-patients
#8
E Vyskocil, D Riss, C Arnoldner, J S Hamzavi, R Liepins, A Kaider, C Honeder, J Fumicz, W Gstöttner, W D Baumgartner
In 2011 a bone conduction implant that utilizes electromagnetic signals transmitted through the skin instead of vibrations was introduced onto the market. The implantable portion (the bone conduction floating mass transducer, or BC-FMT) is an electromagnetic transducer that is fixed to the skull bone with screws and delivers mechanical vibrations to the inner ear (1) . It is often not possible to place the relatively large BC-FMT (15.8 mm in diameter and 8.7 mm in height) exclusively in the bone of the mastoid...
November 12, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27858404/advances-in-multimodal-molecular-imaging
#9
Luigi Auletta, Matteo Gramanzini, Gargiulo Sara, Sandra Albanese, Marco Salvatore, Adelaide Greco
INTRODUCTION: Preclinical molecular imaging is an emerging field. Improving the ability of scientists to study the molecular basis of human pathology in animals is of the utmost importance for future advances in all fields of human medicine. Moreover, the possibility of developing new imaging techniques or of implementing old ones adapted to the clinic is a significant area. EVIDENCE ACQUISITION: Cardiology, neurology, immunology and oncology have all been studied with preclinical molecular imaging...
November 18, 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27830148/reconstruction-for-limited-projection-fluorescence-molecular-tomography-based-on-a-double-mesh-strategy
#10
Huangjian Yi, Xu Zhang, Jinye Peng, Fengjun Zhao, Xiaodong Wang, Yuqing Hou, Duofang Chen, Xiaowei He
Limited-projection fluorescence molecular tomography (FMT) has short data acquisition time that allows fast resolving of the three-dimensional visualization of fluorophore within small animal in vivo. However, limited-projection FMT reconstruction suffers from severe ill-posedness because only limited projections are used for reconstruction. To alleviate the ill-posedness, a feasible region extraction strategy based on a double mesh is presented for limited-projection FMT. First, an initial result is rapidly recovered using a coarse discretization mesh...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27825901/kinesthetic-motor-imagery-training-modulates-frontal-midline-theta-during-imagination-of-a-dart-throw
#11
E Weber, M Doppelmayr
Motor imagery (MI) is a frequently used and effective method for motor learning in sports as well as in other domains. Electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) studies indicated that experts within a certain sport exhibit a more pronounced brain activity during MI as compared to novices. Similar to the execution, during MI the motor sequence has to be planned. Thus, the frontal attentional system, in part represented by the frontal midline theta (4-7Hz), is closely related to these processes and presumably plays a major role in MI as well...
November 5, 2016: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/27809778/pectin-enhances-the-effect-of-fecal-microbiota-transplantation-in-ulcerative-colitis-by-delaying-the-loss-of-diversity-of-gut-flora
#12
Yao Wei, Jianfeng Gong, Weiming Zhu, Hongliang Tian, Chao Ding, Lili Gu, Ning Li, Jieshou Li
BACKGROUND: Fecal microbiota transplantation (FMT) induces remission in ulcerative colitis (UC). However, the treatment effect of FMT diminishes over time. Maintaining the diversity of the gut flora for long periods may improve the effects of FMT in UC. Pectin, which can be fermented by gut microbiota into short-chain fatty acids, is postulated to shape the composition and maintain the balance of gut microbiota following transplantation. This study investigated whether pectin could enhance the effects of FMT in UC patients...
November 3, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27809256/in-vivo-follow-up-of-brain-tumor-growth-via-bioluminescence-imaging-and-fluorescence-tomography
#13
Coralie Genevois, Hugues Loiseau, Franck Couillaud
Reporter gene-based strategies are widely used in experimental oncology. Bioluminescence imaging (BLI) using the firefly luciferase (Fluc) as a reporter gene and d-luciferin as a substrate is currently the most widely employed technique. The present paper compares the performances of BLI imaging with fluorescence imaging using the near infrared fluorescent protein (iRFP) to monitor brain tumor growth in mice. Fluorescence imaging includes fluorescence reflectance imaging (FRI), fluorescence diffuse (optical) tomography (fDOT), and fluorescence molecular Imaging (FMT(®))...
October 31, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27796474/-clostridium-difficile-infection-what-is-currently-available-for-treatment
#14
A Stallmach
Clostridium difficile (C. difficile) is an anaerobic, Gram-positive, spore-forming, toxin-secreting bacillus. It is transmitted via a fecal-oral route and can be found in 1-3 % of the healthy population. Symptoms caused by C. difficile range from uncomplicated diarrhea to a toxic megacolon. The incidence, frequency of recurrence, and mortality rate of C. difficile infections (CDIs) have increased significantly over the past few decades. The most important risk factor is antibiotic treatment in elderly patients and patients with severe comorbidities...
December 2016: Der Internist
https://www.readbyqxmd.com/read/27774226/fda-s-pathway-for-regulation-of-fmt-not-so-fraught
#15
Margaret F Riley, Bernat Olle
No abstract text is available yet for this article.
November 2015: Journal of Law and the Biosciences
https://www.readbyqxmd.com/read/27751177/successful-treatment-with-fecal-microbiota-transplantation-in-patients-with-multiple-organ-dysfunction-syndrome-and-diarrhea-following-severe-sepsis
#16
Yanling Wei, Jun Yang, Jun Wang, Yang Yang, Juan Huang, Hao Gong, Hongli Cui, Dongfeng Chen
BACKGROUND: The dysbiosis of intestinal microbiota plays an important role in the development of gut-derived infections, making it a potential therapeutic target against multiple organ dysfunction syndrome (MODS) after sepsis. However, the effectiveness of fecal microbiota transplantation (FMT) in treating this disease has been rarely investigated. METHODS: Two male patients, a 65-year-old and an 84-year-old, were initially diagnosed with cerebellar hemorrhage and cerebral infarction, respectively, after admission...
October 18, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27743467/therapeutic-modulation-of-the-gut-microbiota-in-ibd-more-questions-to-be-answered
#17
Yu Qi Qiao, Chen Wen Cai, Zhi Hua Ran
Inflammatory bowel disease (IBD) patients exhibit impaired control of the microbiome in the gut. "Dysbiosis" is commonly observed. A Western diet is a risk factor for the development of IBD but may have different effects on the gut microbiota in IBD and non-IBD individuals. Exclusive enteral nutrition (EEN) can induce remission in pediatric Crohn's disease (CD) with a decrease in gut microbiome diversity after EEN treatment. Although there are some theoretical benefits, the actual treatment effects of prebiotics and probiotics in IBD patients can vary...
October 15, 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27738605/failure-of-fecal-microbiota-transplantation-in-a-three-year-old-child-with-severe-refractory-ulcerative-colitis
#18
Hideki Kumagai, Koji Yokoyama, Tomoyuki Imagawa, Shun Inoue, Janyerkye Tulyeu, Mamoru Tanaka, Takanori Yamagata
Fecal microbiota transplantation (FMT) is a treatment designed to correct gut dysbiosis by administration of feces from a healthy volunteer. It is still unclear whether FMT for children with ulcerative colitis (UC) is effective or hazardous. Here we describe a young patient to have received FMT for UC. A three-year-old girl was admitted to our hospital with severe active UC, and treated with aminosalicylates and various immunosuppressive drugs. As remission was not achieved, we decided to try FMT before colectomy...
September 2016: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/27730312/efficacy-and-safety-of-single-fecal-microbiota-transplantation-for-japanese-patients-with-mild-to-moderately-active-ulcerative-colitis
#19
Atsushi Nishida, Hirotsugu Imaeda, Masashi Ohno, Osamu Inatomi, Shigeki Bamba, Mitsushige Sugimoto, Akira Andoh
BACKGROUND: The clinical utility of fecal microbiota transplantation (FMT) in patients with ulcerative colitis (UC) is still controversial. We investigated the efficacy and safety of single FMT for patients with mild to moderately active UC in a Japanese population. METHODS: Fifty-seven patients were evaluated for eligibility, and 16 patients were excluded. Forty-one patients with UC refractory to standard medical therapy were treated with single FMT by colonoscopic administration...
October 11, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27724956/long-term-effects-on-luminal-and-mucosal-microbiota-and-commonly-acquired-taxa-in-faecal-microbiota-transplantation-for-recurrent-clostridium-difficile-infection
#20
Jonna Jalanka, Eero Mattila, Hanne Jouhten, Jorn Hartman, Willem M de Vos, Perttu Arkkila, Reetta Satokari
BACKGROUND: Faecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridium difficile infection (rCDI). It restores the disrupted intestinal microbiota and subsequently suppresses C. difficile. The long-term stability of the intestinal microbiota and the recovery of mucosal microbiota, both of which have not been previously studied, are assessed herein. Further, the specific bacteria behind the treatment efficacy are also investigated. METHODS: We performed a high-throughput microbiota profiling using a phylogenetic microarray analysis of 131 faecal and mucosal samples from 14 rCDI patients pre- and post-FMT during a 1-year follow-up and 23 samples from the three universal donors over the same period...
October 11, 2016: BMC Medicine
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