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https://www.readbyqxmd.com/read/28723262/the-risk-of-inflammatory-bowel-disease-flares-after-fecal-microbiota-transplantation-systematic-review-and-meta-analysis
#1
Taha Qazi, Thelina Amaratunga, Edward L Barnes, Monika Fischer, Zain Kassam, Jessica R Allegretti
BACKGROUND: Several studies have suggested worsening in inflammatory bowel disease (IBD) activity following fecal microbiota transplantation (FMT) Aim: We aimed to assess the risk of worsening in IBD activity following FMT. METHODS: An electronic search was conducted using MEDLINE (1946-June 2016), EMBASE (1954-June 2016) and Cochrane Central Register of Controlled Trials (2016). Studies in which FMT was provided to IBD patients for IBD management or CDI treatment were included...
July 19, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28718381/histological-and-immunohistochemical-characterization-of-the-similarity-and-difference-between-ovarian-endometriomas-and-deep-infiltrating-endometriosis
#2
Xishi Liu, Qi Zhang, Sun-Wei Guo
Ovarian endometrioma (OMA) and deep infiltrating endometriosis (DIE) have long been recognized to have different histology and, as such, postulated to be 2 separate disease entities. Few studies, however, have attempted to elucidate the causes for their differences. Making use of ectopic endometrial tissue samples from 25 and 20 women with OMA and DIE, respectively, and control endometrial tissue samples from 25 women without endometriosis, we conducted an immunohistochemical analysis to evaluate the expression of a group of carefully chosen markers for epithelial-mesenchymal transition (EMT), fibroblast-to-myofibroblast transdifferentiation (FMT), smooth muscle metaplasia (SMM), fibrosis, vascularity, hormonal receptors, and proteins involved in epigenetic modifications...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28708706/return-to-driving-after-hip-arthroscopy
#3
Amit M Momaya, Despina Stavrinos, Benjamin McManus, Shannon M Wittig, Benton Emblom, Reed Estes
OBJECTIVE: The objective of this study was to evaluate patients' braking performance using a modern driving simulator after undergoing a right hip arthroscopy. DESIGN: This prospective study included 5 total driving sessions at which measurements were taken. SETTING: The study was conducted at an academic medical center. PATIENTS: A total of 14 patients scheduled to undergo a right hip arthroscopy were enrolled and compared with a control group of 17 participants to account for a potential learning phenomenon...
July 11, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28707337/systematic-review-with-meta-analysis-the-efficacy-of-faecal-microbiota-transplantation-for-the-treatment-of-recurrent-and-refractory-clostridium-difficile-infection
#4
REVIEW
M N Quraishi, M Widlak, N Bhala, D Moore, M Price, N Sharma, T H Iqbal
BACKGROUND: Clostridium difficile infection (CDI) is the commonest nosocomial cause of diarrhoea. Faecal microbiota transplantation (FMT) is an approved treatment for recurrent or refractory CDI but there is uncertainty about its use. AIM: To evaluate the efficacy of FMT in treating recurrent and refractory CDI and investigate outcomes from modes of delivery and preparation. METHODS: A systematic review and meta-analysis was performed. MEDLINE, EMBASE, CINAHL, Cochrane Library, trial registers and conference proceedings were searched...
July 14, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28702022/preparing-the-gut-with-antibiotics-enhances-gut-microbiota-reprogramming-efficiency-by-promoting-xenomicrobiota-colonization
#5
Shou K Ji, Hui Yan, Tao Jiang, Chun Y Guo, Jing J Liu, Shuang Z Dong, Kai L Yang, Ya J Wang, Zhi J Cao, Sheng L Li
Gut microbiota plays multiple important roles in intestinal and physiological homeostasis, and using fecal microbiota transplantation (FMT) to reprogram gut microbiota has demonstrated promise for redressing intestinal and physiological disorders. This study tested the alterations in reprogramming efficiency caused by different gut preparation procedures and explored the associated underlying mechanisms. We prepared the guts of mice for FMT by administering one of the three most-clinically used pretreatments [antibiotics, bowel cleansing (BC) solution, or no pretreatment], and we found that preparing the gut with antibiotics induced a more efficient modification of the gut bacterial community than was induced by either of the other two pretreatment types...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28691996/fecal-microbiota-therapy-with-a-focus-on-c-difficile-infection
#6
Lawrence J Brandt
There has been a paradigm shift in our view of bacteria away from their role as just pathogens. We now have a deepening appreciation of their critical influences in our health maintenance, including energy harvest, metabolism, intestinal development, cell proliferation, nervous system and immune function, as well as their role to protect against intestinal and other infections. A perturbed intestinal microbiome has been associated with an increasing number of gastrointestinal (GI) and non-GI diseases but particularly with C...
July 7, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28685630/the-potential-role-of-fecal-microbiota-transplantation-in-the-treatment-of-inflammatory-bowel-disease
#7
Maitham Abbas Khajah
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of an unknown etiology. Its pathogenesis involves an interplay of infectious, genetic, environmental, and immunological factors. The current therapeutic options have various limitations in terms of cost, side effect profile, and the development of drug resistance and dependence. Therefore, there is a need to develop future therapeutic options which are safe and effective to control the inflammatory process. This review focuses in a method for the administration of fecal matters (which contains a mixture of various commensals) from a healthy donor to the inflamed colon called fecal microbiota transplantation (FMT) aiming to correct the underlying dysbiosis in the gut as one of the major driving force for the inflammatory process...
July 7, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28684845/multiple-fresh-fecal-microbiota-transplants-induces-and-maintains-clinical-remission-in-crohn-s-disease-complicated-with-inflammatory-mass
#8
Zhi He, Pan Li, Jianguo Zhu, Bota Cui, Lijuan Xu, Jie Xiang, Ting Zhang, Chuyan Long, Guangming Huang, Guozhong Ji, Yongzhan Nie, Kaichun Wu, Daiming Fan, Faming Zhang
The ancient Chinese medical literature, as well as our prior clinical experience, suggests that fecal microbiota transplantation (FMT) could treat the inflammatory mass. We aimed to evaluate the efficacy and safety of multiple fresh FMTs for Crohn's disease (CD) complicated with intraabdominal inflammatory mass. The "one-hour FMT protocol" was followed in all patients. Twenty-five patients were diagnosed with CD and related inflammatory mass by CT or MRI. All patients received the initial FMT followed by repeated FMTs every 3 months...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28677158/update-on-intestinal-microbiota-in-crohn-s-disease-2017-mechanisms-clinical-application-adverse-reactions-and-outlook
#9
REVIEW
Zhaohua Shen, Changxin Zhu, Yongsheng Quan, Wei Yuan, Shuai Wu, Zhenyu Yang, Weiwei Luo, Bei Tan, Xiaoyan Wang
The pathogenesis of CD is complex and it is thought to be associated with the environment, immune, hereditary, microbe and other factors. If the balance between the host and the intestinal microbes in CD patients was broken, immune-inflammatory response of susceptible individuals might be triggered. Probiotics could improve the intestinal microbial flora balance and treat human effectively. There are several new mechanisms which might explain the role of probiotics. Fecal microbiota transplantation (FMT) is becoming more and more attractive in treating a large amount of digestive system diseases which are related to the dysbiosis of intestinal microbiota...
July 5, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28666703/a-comparative-study-of-med-el-fmt-attachment-to-the-long-process-of-the-incus-in-intact-middle-ears-and-its-attachment-to-disarticulated-stapes-head
#10
Tao Chen, Liu-Jie Ren, Dong-Ming Yin, Jia Li, Lin Yang, Pei-Dong Dai, Tian-Yu Zhang
The Vibrant Soundbridge(©) (VSB) active middle-ear implant provides an effective treatment for mild-to-severe sensorineural hearing loss in the case of normal middle ear anatomy and mixed hearing loss in middle ear malformation. The VSB floating mass transducer (FMT), with proper couplers, can be installed on various structures of the ossicular chain, e.g., the short and long process of the incus, the stapes head, and the stapes footplate. A long process (LP) coupler is most commonly used for FMT attachment to the long process of the incus with intact ossicular chain, while CliP and Bell couplers are two standardized and reliable methods for FMT attachment to the stapes head with missing incus and malleus...
June 23, 2017: Hearing Research
https://www.readbyqxmd.com/read/28658615/pp6-disruption-synergizes-with-oncogenic-ras-to-promote-jnk-dependent-tumor-growth-and-invasion
#11
Xianjue Ma, Jin-Yu Lu, Yongli Dong, Daming Li, Juan N Malagon, Tian Xu
RAS genes are frequently mutated in cancers, yet an effective treatment has not been developed, partly because of an incomplete understanding of signaling within Ras-related tumors. To address this, we performed a genetic screen in Drosophila, aiming to find mutations that cooperate with oncogenic Ras (Ras(V12)) to induce tumor overgrowth and invasion. We identified fiery mountain (fmt), a regulatory subunit of the protein phosphatase 6 (PP6) complex, as a tumor suppressor that synergizes with Ras(V12) to drive c-Jun N-terminal kinase (JNK)-dependent tumor growth and invasiveness...
June 27, 2017: Cell Reports
https://www.readbyqxmd.com/read/28657955/the-hannover-coupler-controlled-static-prestress-in-round-window-stimulation-with-the-floating-mass-transducer
#12
Mathias Müller, Rolf Salcher, Thomas Lenarz, Hannes Maier
INTRODUCTION: Stimulation of the cochlear round window (RW) with the floating mass transducer (FMT) still suffers from large variation in clinical outcomes. Beside the geometric mismatch between RW and FMT diameter that is a known limiting factor in achieving optimal coupling between actuator and RW membrane, the applied static force between FMT and RW is usually undefined. In this study, the feasibility and efficacy of a specially designed FMT coupler permitting application of static preloads to the RW membrane to optimize FMT-RW coupling was investigated...
June 27, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28655316/reconstruction-of-fluorescence-molecular-tomography-with-a-cosinoidal-level-set-method
#13
Xuanxuan Zhang, Xu Cao, Shouping Zhu
BACKGROUND: Implicit shape-based reconstruction method in fluorescence molecular tomography (FMT) is capable of achieving higher image clarity than image-based reconstruction method. However, the implicit shape method suffers from a low convergence speed and performs unstably due to the utilization of gradient-based optimization methods. Moreover, the implicit shape method requires priori information about the number of targets. METHODS: A shape-based reconstruction scheme of FMT with a cosinoidal level set method is proposed in this paper...
June 27, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28652664/can-fecal-microbiota-transplantation-cure-irritable-bowel-syndrome
#14
Sofie Ingdam Halkjær, Anders Watt Boolsen, Stig Günther, Alice Højer Christensen, Andreas Munk Petersen
AIM: To verify the utility of treatment with fecal microbiota transplantation (FMT) in patients with irritable bowel syndrome (IBS). METHODS: We searched EMBASE, Cochrane Library and PubMed in March, 2017. The reviewed literature was based on two systematic searches in each of the databases. The MeSH terms used were IBS and fecal microbiota transplantation and the abbreviations IBS and FMT. Reference lists from the articles were reviewed to identify additional pertinent articles...
June 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28646951/fecal-microbiota-transplantation-for-recurrent-clostridium-difficile-infection-in-children
#15
Becky Chen, Vishal Avinashi, Simon Dobson
Fecal microbiota transplantation (FMT) is a relatively simple, promising treatment for recurrent Clostridium difficile infection. While there are a wide variety of approaches including mode of delivery, the results are nonetheless encouraging, even amongst younger children. Experience with FMT in the pediatric population is increasing, showing similar success compared to adults. This article will provide an overview of C. difficile infection along with review of the rationale, methods and complications of FMT including the current experience of FMT in children...
June 2017: Journal of Infection
https://www.readbyqxmd.com/read/28628918/bifidobacterium-rich-fecal-donor-may-be-a-positive-predictor-for-successful-fecal-microbiota-transplantation-in-patients-with-irritable-bowel-syndrome
#16
Shinta Mizuno, Tatsuhiro Masaoka, Makoto Naganuma, Taishiro Kishimoto, Momoko Kitazawa, Shunya Kurokawa, Moeko Nakashima, Kozue Takeshita, Wataru Suda, Masaru Mimura, Masahira Hattori, Takanori Kanai
BACKGROUND/AIMS: Dysbiosis is associated with various systemic disorders including irritable bowel syndrome (IBS). Fecal microbiota transplantation (FMT) might restore intestinal microbial balance. The study aimed to determine the safety and efficacy of FMT in IBS patients, as well as also positive predictors for FMT. METHODS: This was a single-arm, open-label study. Eligible patients were diagnosed based on Rome III Diagnostic Criteria. Fecal materials were administered to the patient via colonoscopy...
June 21, 2017: Digestion
https://www.readbyqxmd.com/read/28626876/optical-molecular-imaging-guided-radiation-therapy-part-2-integrated-x-ray-and-fluorescence-molecular-tomography
#17
Junwei Shi, Thirupandiyur S Udayakumar, Zhiqun Wang, Nesrin Dogan, Alan Pollack, Yidong Yang
PURPOSE: Differentiating tumor from its surrounding soft tissues is challenging for x-ray computed tomography (CT). Fluorescence molecular tomography (FMT) can directly localize the internal tumors targeted with specific fluorescent probes. A FMT system was developed and integrated onto a CT guided irradiator to improve tumor localization for image guided radiation. METHODS: The FMT system was aligned orthogonal to the cone beam CT onboard our previously developed image guided small animal arc radiation treatment system (iSMAART)...
June 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28612983/systematic-review-with-meta-analysis-faecal-microbiota-transplantation-for-the-induction-of-remission-for-active-ulcerative-colitis
#18
REVIEW
S P Costello, W Soo, R V Bryant, V Jairath, A L Hart, J M Andrews
BACKGROUND: Faecal microbiota transplantation (FMT) is emerging as a novel therapy for ulcerative colitis (UC). Interpretation of efficacy of FMT for UC is complicated by differences among studies in blinding, FMT administration procedures, intensity of therapy and donor stool processing methods. AIM: To determine whether FMT is effective and safe for the induction of remission in active UC. METHODS: Medline (Ovid), Embase and the Cochrane Library were searched from inception through February 2017...
August 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28611478/therapy-bacteriophages-important-for-fmt-efficacy
#19
Iain Dickson
No abstract text is available yet for this article.
July 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28609252/fecal-microbiota-transplantation-in-metabolic-syndrome-history-present-and-future
#20
P F de Groot, M N Frissen, N C de Clercq, M Nieuwdorp
The history of fecal microbiota transplantation (FMT) dates back even to ancient China. Recently, scientific studies have been looking into FMT as a promising treatment of various diseases, while in the process teaching us about the interaction between the human host and its resident microbial communities. Current research focuses mainly on Clostridium difficile infections, however interest is rising in other areas such as inflammatory bowel disease (IBD) and the metabolic syndrome. With regard to the latter, the intestinal microbiota might be causally related to the progression of insulin resistance and diabetes...
May 4, 2017: Gut Microbes
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