keyword
https://read.qxmd.com/read/38440474/outcomes-of-central-neck-dissection-for-papillary-thyroid-carcinoma-in-primary-versus-revision-setting
#21
JOURNAL ARTICLE
Hasan Alansari, Nalin Mathur, Husain Ahmadi, Zaki Hassan AlWatban, Naji Alamuddin, Omar Sabra
INTRODUCTION: Surgery in the central compartment after previous thyroidectomy involves an increased risk of injury to critical organs, including the parathyroids and recurrent laryngeal nerve. Contrastingly, primary central neck dissection involves a relatively low operative risk. OBJECTIVE: This study aimed to compare the outcomes of central neck dissection in primary versus revision settings with respect to the lymph node yield and complication rates. METHODS: This single-center prospective study included patients who underwent primary or revision neck dissection surgery for histologically confirmed thyroid malignancy between January 2018 and January 2022...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38435924/vara-deformity-and-subluxed-humeral-heads-an-unusual-sign-in-pseudohypoparathyroidism
#22
Mason A Williams, Kharina Guruvadoo, Lena Naffaa
Pseudohypoparathyroidism is a rare disorder characterized by end-organ resistance to intact parathyroid hormone (PTH) and concomitant laboratory findings of hypocalcemia and hyperphosphatemia. Radiologic evidence of the disease may manifest as a variety of bone abnormalities. This case describes an 11-year-old female with a history of repaired bilateral slipped capital femoral epiphysis who presented with a limited range of motion of the bilateral upper extremities. Laboratory findings were consistent with pseudohypoparathyroidism...
January 2024: Curēus
https://read.qxmd.com/read/38435884/the-relationship-between-gestational-diabetes-and-the-risk-of-cancer-a-systematic-review
#23
REVIEW
Ethan Slouha, Kaitlyn M Gates, Hanin Al-Geizi, Esther Baah, Lucy A Clunes, Theofanis F Kollias
Gestational diabetes mellitus (GDM) is one of the most common endocrine disorders to occur during pregnancy due to the increase in circulating human placental lactogen (hPL) and possible beta-cell sensitivity. While GDM can be managed either with diet and exercise or pharmacological interventions, it is associated with significant maternal and neonatal complications. Maternal complications include short- and long-term conditions such as pre-eclampsia, preterm birth, arrest of labor, future development of type 2 diabetes mellitus (T2DM), and cardiovascular disorders...
January 2024: Curēus
https://read.qxmd.com/read/38434172/small-intestinal-volvulus-in-47-cows
#24
JOURNAL ARTICLE
Ueli Braun, Christian Gerspach, Claudia Volz, Monika Hilbe, Karl Nuss
OBJECTIVE: To describe the findings, treatment, and outcome of small intestinal volvulus (SIV) in 47 cows. ANIMALS AND PROCEDURE: Retrospective analysis of medical records. Comparison of the findings for 18 surviving and 29 non-surviving cows. RESULTS: The most common abnormal vital signs were tachycardia (68.0%), tachypnea (59.6%), and decreased rectal temperature (51.1%). Signs of colic occurred in 66.0% of cows in the study. Rumen motility was reduced or absent in 93...
March 2024: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://read.qxmd.com/read/38433542/-hyperparathyroidism-of-different-genesis-in-young-patients-with-turner-syndrome-case-series-and-brief-review
#25
JOURNAL ARTICLE
I D Ozhimalov, T K Karavaynaya, Ju D Fedorova, A M Gorbacheva, E E Bibik, I S Maganeva, A К Eremkina, N G Mokrysheva
Hyperparathyroidism is a syndrome characterized by an excessive secretion of parathyroid hormone. Etiologically, hyperparathyroidism is subdivided into primary hyperparathyroidism, which develops as a result of parathyroid adenoma, carcinoma or hyperplasia, and secondary hyperparathyroidism, which happens as a compensatory response to a hypocalcemia caused by condition outside the parathyroid glands. Turner syndrome may also be accompanied by mineral metabolism disorders of various etiology. An association of hyperparathyroidism and Turner syndrome is interesting because of multifactorial impact on bone mineral density, but only few cases of such coexistence have been previously described in the literature...
February 28, 2024: Problemy E̊ndokrinologii
https://read.qxmd.com/read/38433540/-association-between-preoperative-cholecalciferol-therapy-and-hypocalcemia-after-parathyroidectomy-in-patients-with-primary-hyperparathyroidism
#26
JOURNAL ARTICLE
A R Elfimova, A K Eremkina, O Yu Rebrova, E V Kovaleva, N G Mokrysheva
BACKGROUND: Primary hyperparathyroidism (PHPT) is a endocrine disorder characterized by excessive secretion of parathyroid hormone (PTH) from parathyroid gland tumors. Parathyroidectomy (PTE) is the main treatment for PHPT, but it can lead to hypocalcemia in up to 46% of cases. Hypocalcemia is associated with seizures and life-threatening cardiac arrhythmias, and vitamin D deficiency can exacerbate PHPT severity and contribute to «hungry bones syndrome,» resulting in severe and persistent postoperative hypocalcemia...
February 28, 2024: Problemy E̊ndokrinologii
https://read.qxmd.com/read/38428491/intravenous-lipopolysaccharide-challenge-in-early-versus-mid-lactation-dairy-cattle-i-the-immune-and-inflammatory-responses
#27
JOURNAL ARTICLE
J Opgenorth, E J Mayorga, M A Abeyta, B M Goetz, S Rodriguez-Jimenez, A D Freestone, J L McGill, L H Baumgard
Cows in early lactation (EL) are purportedly immune suppressed, which renders them more susceptible to disease. Thus, the study objective was to compare key biomarkers of immune activation from i.v. lipopolysaccharide (LPS) between EL and mid-lactation (ML) cows. Multiparous EL (20 ± 2 DIM; n = 11) and ML (131 ± 31 DIM; n = 12) cows were enrolled in a 2 × 2 factorial design and assigned to 1 of 2 treatments by lactation stage (LS): (1) EL (EL-LPS; n = 6) or ML (ML-LPS; n = 6) cows administered a single LPS bolus from Escherichia coli O55:B5 (0...
February 28, 2024: Journal of Dairy Science
https://read.qxmd.com/read/38427111/treatment-of-bone-metastases-from-solid-tumors-with-bone-modifying-agents-a-web-survey-of-italian-oncologists-investigating-patterns-of-practice-drug-prescription-and-prevention-of-side-effects
#28
JOURNAL ARTICLE
Vittorio Fusco, Massimo Di Maio, Anna Amela Valsecchi, Daniele Santini, Marcello Tucci, Ugo De Giorgi, Paolo Bossi, Toni Ibrahim, Luigi Cavanna, Gaetano Lanzetta, Maura Rossi, Giorgia Rossetti, Mario Airoldi, Alessandro Comandone, Saverio Cinieri
PURPOSE: Optimal use of bone-modifying agents (BMAs) in patients with bone metastases from solid tumors is uncertain in some aspects: the drug choice; the planned treatment duration and long-term therapy; the prevention and management of possible side effects, including renal toxicity, hypocalcaemia, and medication-related osteonecrosis of the jaw (MRONJ). METHODS: Italian oncologists were invited to fulfil a 24-question web survey about prescription of BMAs for bone metastases of breast cancer, prostate cancer, and other solid tumors...
March 1, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38425628/nonfebrile-seizures-in-pediatrics-key-points-to-remember
#29
Mariana M Anjos, Ana M Figueireido, Patricia Cardoso, Filipa Costa, Julieta Morais
Seizures are the most common neurological disorder in pediatrics, and their initial approach aims at clinical stabilization. A thorough patient evaluation may provide important clues for the etiological diagnosis. A 12-month-old female child was observed in the emergency department after experiencing her first apyretic seizure. She had a history of congenital alopecia and, on physical examination, presented subtotal alopecia and milia. Initial investigation revealed hypocalcemia; therefore, intravenous calcium correction was started with a partial response...
January 2024: Curēus
https://read.qxmd.com/read/38422761/does-preoperative-calcium-and-1-25-oh-vitamin-d-supplementation-impact-postoperative-hypocalcemia-and-length-of-stay-following-pediatric-thyroidectomy
#30
JOURNAL ARTICLE
Laura Banks, Natalie A Kelly, Amanda Onwuka, Abdulrahman Althubaiti, Cecilia Damilano, Robert P Hoffman, Jennifer H Aldrink, Kris R Jatana, Patrick Walz
OBJECTIVE: To investigate whether perioperative calcium and 1,25 OH vitamin D supplementation (PCDS) influences the rates of postoperative hypocalcemia and length of stay (LOS) following pediatric thyroidectomy. STUDY DESIGN: Retrospective Cohort Review. SETTING: Tertiary children's hospital. METHODS: 94 patients who underwent completion or total thyroidectomy with or without concomitant neck dissection from 2010 to 2020 at a single institution were included...
March 2024: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/38413113/ultrasound-guided-radiofrequency-ablation-in-tertiary-hyperparathyroidism-a-prospective-study
#31
JOURNAL ARTICLE
Erya Deng, Tingting Jiang, Huihui Chai, Ning Weng, Hongfeng He, Zhengxian Zhang, Chengzhong Peng, Wenwen Yue, Huixiong Xu
OBJECTIVE: To prospectively evaluate the outcomes of ultrasound (US)-guided radiofrequency ablation (RFA) in tertiary hyperparathyroidism (THPT). MATERIALS AND METHODS: Patients with THPT underwent RFA between September 2017 and January 2022. Laboratory parameters, including serum intact parathyroid hormone (iPTH) levels, were monitored for 48 months after RFA and compared with the levels at baseline. Complications related to RFA and changes in hyperparathyroidism-related clinical symptoms were recorded before and after RFA...
March 2024: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://read.qxmd.com/read/38412278/in-brief-severe-hypocalcemia-with-denosumab-prolia-in-chronic-kidney-disease
#32
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 4, 2024: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/38410767/case-report-severe-vitamin-d-deficiency-in-a-girl-with-inflammatory-myopathy-and-myonecrosis
#33
Andrew Kanouse, Benjamin Udoka Nwosu, Parissa Salemi
Inflammatory myopathies are a rare group of disorders that can cause significant disruption in the ability of an individual to adequately perform activities of daily living. In this case report, we present a case of a girl presenting with a substantial compromise of her ambulation with a muscle biopsy consistent with myonecrosis. She was subsequently diagnosed with an inflammatory myopathy and started on glucocorticoid and methotrexate therapy with minimal symptomatic improvement. Further in her clinical course, hypocalcemia and an undetectable 25-hydroxyvitamin D level were detected...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38409169/azathioprine-and-hydroxychloroquine-overdose-in-sj%C3%A3-gren-s-syndrome-patient-with-hypocalcemia-a-case-report
#34
JOURNAL ARTICLE
Alireza Kooshki, Omid Mehrpour, Samaneh Nakhaee
INTRODUCTION: Hydroxychloroquine and azathioprine have been routinely used to control and treat primary and secondary Sjögren's syndrome, which potentially triggered some overdoses by these drugs. Toxicity from hydroxychloroquine and azathioprine manifests in the form of cardiac conduction abnormalities, nausea, vomiting, and muscle weakness. Recognizing these unique drug overdoses and management of these toxicities is important. This case report aims to expand our current understanding of these drug overdoses and their management and also underscores the importance of anticipating and identifying fewer common complications, such as hypocalcemia...
February 27, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38408341/compressive-myelopathy-from-diffuse-spinal-dural-calcifications-in-a-patient-with-end-stage-renal-disease-illustrative-case
#35
JOURNAL ARTICLE
Alexis Malecki, Jacob Pawloski, Anthony Anzalone, Kelly Shaftel, Hassan Ali Fadel, Ian Lee
BACKGROUND: Diffuse spinal dural calcification is a rare disorder associated with hyperparathyroidism, including the secondary forms associated with renal failure, osteodystrophy, and chronic hypocalcemia. Here, the authors report a rare case of diffuse dural calcification causing spinal cord compression with myelopathy, requiring decompressive surgery with duraplasty to achieve adequate decompression. OBSERVATIONS: A 46-year-old male with a history of renal failure on dialysis presented with 2 months of progressive neuropathic pain, lower-extremity weakness, and nonsustained clonus...
February 26, 2024: J Neurosurg Case Lessons
https://read.qxmd.com/read/38407281/clozapine-use-in-22q11-2-deletion-syndrome-a-systematic-review-of-the-literature
#36
JOURNAL ARTICLE
Mark Ainsley Colijn
BACKGROUND: 22q11.2 deletion syndrome confers significant risk for the development of schizophrenia. While current recommendations regarding the management of psychotic symptoms in affected individuals are generally in keeping with treatment guidelines for general schizophrenia populations, evidence for the use of clozapine has come from case reports and retrospective observational data. As no reviews on the topic currently exist, a systematic review of clozapine use in 22q11.2 deletion syndrome was completed...
February 12, 2024: Journal of Clinical Psychopharmacology
https://read.qxmd.com/read/38404648/severe-hypercalcemia-caused-by-calcium-alkali-syndrome-after-15%C3%A2-years-of-postoperative-hypoparathyroidism-in-a-patient-with-undiagnosed-hyperaldosteronism
#37
Natália Diel Boufleuer, Dimitris V Rados, Tatiana Zambonato, Clara K Maraschin, Beatriz D Schaan
INTRODUCTION: The triad of hypercalcemia, metabolic alkalosis, and acute kidney injury associated with ingesting high doses of calcium and absorbable bases characterizes the calcium-alkali syndrome. Clinical Case . We report the case of a patient with postthyroidectomy hypoparathyroidism 15 years ago due to differentiated thyroid cancer who presented with severe hypercalcemia. He had adequate control of calcemia for many years on treatment with calcitriol and calcium carbonate and hypertension treated with amlodipine, losartan, and hydrochlorothiazide...
2024: Case Reports in Endocrinology
https://read.qxmd.com/read/38395399/effect-of-dietary-phosphorus-deprivation-during-the-dry-period-on-the-liver-transcriptome-of-high-yielding-periparturient-dairy-cows
#38
JOURNAL ARTICLE
Robert Ringseis, Sophia Wächter, Imke Cohrs, Klaus Eder, Walter Grünberg
While dietary phosphorus (P) deprivation extending from the dry period into early lactation impairs health and productivity of cows, restricting dietary P supply during the dry period not only appears to be innocuous but rather effectively mitigates hypocalcemia during the first wk of lactation. To investigate possible negative metabolic effects of P deprivation during the dry period, the present study tested the hypothesis that restarted dietary P supply during the dry period alters the liver transcriptome of dairy cows during the periparturient period...
February 21, 2024: Journal of Dairy Science
https://read.qxmd.com/read/38393510/novel-4-18-mb-deletion-resulting-in-2q37-microdeletion-syndrome-combined-with-pth-resistance-found-in-one-chinese-patient
#39
JOURNAL ARTICLE
Yi Yang, Siqi Jiang, Min Nie, Yan Jiang, Mei Li, Weibo Xia, Xiaoping Xing, Ou Wang, Hui Pan
BACKGROUND: 2q37 microdeletion syndrome is a rare clinical condition characterized by a series of physical abnormalities. Its Albright hereditary osteodystrophy (AHO)-like manifestations and possible complication of biochemical abnormalities indicating PTH resistance greatly increased the likelihood of misdiagnosis with classic pseudohypoparathyroidism (PHP) caused by GNAS mutation or methylation alteration, even though there have only been six reports of such clinical occasions. PURPOSE: to investigate the underlying genetic defect in a male patient presenting hypocalcemia, elevated PTH and with a history of kyphosis...
February 23, 2024: Endocrine
https://read.qxmd.com/read/38392648/performance-in-behavioral-testing-in-an-animal-model-of-post-surgical-hypoparathyroidism
#40
JOURNAL ARTICLE
Cristina Dettori, Francesca Ronca, Giulia Di Buono, Alessandro Saba, Francesca Di Lupo, Beatrice Polini, Caterina Ricardi, Sabina Frascarelli, Filomena Cetani, Claudio Marcocci, Riccardo Zucchi, Grazia Chiellini, Marco Scalese, Federica Saponaro
BACKGROUND: Hypoparathyroidism (HypoPT) is characterized by hypocalcemia and undetectable/inappropriately low PTH. Post-surgical HypoPT (PS-HypoPT) is the most common cause. Patients with PS-HypoPT present neuropsychological symptoms, probably due to the PTH deprivation in the central nervous system (CNS). However, these mechanisms are still not elucidated. The aim of this study was to evaluate the effects of PTH deprivation on CNS in an animal model of PS-HypoPT via a cognitive/behavioral assessment approach...
February 17, 2024: Journal of Personalized Medicine
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