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https://www.readbyqxmd.com/read/29132247/management-of-a-rare-case-with-severe-hydrofluoric-acid-burns-important-roles-of-neutralizers-and-continuous-renal-replacement-therapy
#1
Yuanhai Zhang, Xingang Wang, Yuezhen Liu, Xinhua Jiang, Chunjiang Ye, Liangfang Ni, Liping Zhang, Jianfen Zhang, Bin Xu, Chunmao Han
Hydrofluoric acid (HF), a dangerous inorganic acid, is widely used in various industries and in daily life. Chemical burns caused by HF exposure occur more frequently in some regions worldwide. It has been reported that some cases with HF burns can be lethal due to the hypertoxicity of HF. In this article, we present a case of a 24-year-old worker who suffered HF burns by 53% HF solution to his face, neck, and nasal cavity. This patient quickly developed electrolyte disturbance, that is, hypocalcemia, and hypopotassemia, and myocardial injury after exposure...
November 1, 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/29131092/value-of-intraoperative-parathyroid-hormone-assay-during-parathyroidectomy-in-dialysis-and-renal-transplant-patients-with-secondary-and-tertiary-hyperparathyroidism
#2
Amr El-Husseini, Kevin Wang, Annick Edon, David Saxon, Florence Lima, David Sloan, B Peter Sawaya
BACKGROUND: In dialysis and renal transplant patients with secondary and tertiary hyperparathyroidism (HPT), the value of intraoperative parathyroid hormone (ioPTH) during parathyroidectomy (PTX) and its association with long-term PTH levels are unknown. The present study aims at evaluating the relationship of ioPTH with long-term PTH levels post-PTX in dialysis and renal transplant patients in a single-center study. METHODS: The ioPTH was measured in 57 dialysis patients (33 females and 24 males) and 18 renal transplant recipients (12 males and 6 females) who underwent PTX from 2005 to 2015 for refractory HPT...
November 9, 2017: Nephron
https://www.readbyqxmd.com/read/29130003/spontaneous-tumor-lysis-syndrome-due-to-uterine-leiomyosarcoma-with-lung-metastases
#3
Vivek Alaigh, Debapriya Datta
Tumor lysis syndrome (TLS) is an oncologic emergency characterized by a combination of metabolic derangements (hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia) caused by rapid turnover from cell destruction in certain cancers. These metabolic derangements can lead to seizures, cardiac arrhythmias, renal failure, and death. TLS is usually seen after the initiation of chemotherapy for hematologic malignancies. TLS occurring spontaneously, without initiation of chemotherapy, is rare and its occurrence in solid tumors is rarer still...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/29124559/hungry-bone-syndrome-two-weeks-after-starting-cinacalcet-a-call-for-caution
#4
Sahar H Koubar, Abd Assalam Qannus, Walid Medawar, Ali K Abu-Alfa
Cinacalcet is an effective and safe alternative to parathyroidectomy in end stage renal disease (ESRD) patients with secondary hyperparathyroidism. Hypocalcemia is a known complication of treatment that is usually readily reversible upon discontinuation of the drug. It rarely manifests severely and symptomatically requiring hospital admission. We present the case of a 55 year old man with severe, symptomatic and prolonged hypocalcemia that occurred 2 weeks after starting cinacalcet. Cinacalcet induced a state of pharmacological parathyroidectomy with subsequent hungry bone syndrome...
November 9, 2017: CEN Case Reports
https://www.readbyqxmd.com/read/29122325/impact-of-autofluorescence-based-identification-of-parathyroids-during-total-thyroidectomy-on-postoperative-hypocalcemia-a-before-and-after-controlled-study
#5
Fares Benmiloud, Stanislas Rebaudet, Arthur Varoquaux, Guillaume Penaranda, Marie Bannier, Anne Denizot
BACKGROUND: The clinical impact of intraoperative autofluorescence-based identification of parathyroids using a near-infrared camera remains unknown. METHODS: In a before and after controlled study, we compared all patients who underwent total thyroidectomy by the same surgeon during Period 1 (January 2015 to January 2016) without near-infrared (near-infrared- group) and those operated on during Period 2 (February 2016 to September 2016) using a near-infrared camera (near-infrared+ group)...
November 6, 2017: Surgery
https://www.readbyqxmd.com/read/29120517/outpatient-versus-inpatient-thyroidectomy-a-systematic-review-and-meta-analysis
#6
REVIEW
Daniel J Lee, Christopher J Chin, Chris J Hong, Stefan Perera, Ian J Witterick
BACKGROUND: Outpatient thyroidectomy has gained popularity due to improved resource utilization. METHODS: We conducted a systematic review and meta-analysis using MEDLINE, EMBASE, CINAHL, Web of Science, and the Cochrane library. We included all studies examining the outcomes of outpatient thyroidectomy as compared with those of inpatient thyroidectomy. Risk of bias was assessed using the Newcastle-Ottawa scale. Postoperative complications (hematoma, hypocalcemia, and recurrent laryngeal nerve injury) and readmission/reintervention rates were compared...
November 9, 2017: Head & Neck
https://www.readbyqxmd.com/read/29116414/effect-of-denosumab-administration-on-low-bone-mineral-density-t-score-1-0-to-2-5-in-postmenopausal-japanese-women-receiving-adjuvant-aromatase-inhibitors-for-non-metastatic-breast-cancer
#7
Katsuhiko Nakatsukasa, Hiroshi Koyama, Yoshimi Ouchi, Kouichi Sakaguchi, Yoshifumi Fujita, Takayuki Matsuda, Makoto Kato, Eiichi Konishi, Tetsuya Taguchi
Although adjuvant aromatase inhibitor (AI) therapy is widely used in postmenopausal women with hormone receptor-positive breast cancer, it is known to be associated with bone loss and increased fracture risk. Denosumab, a fully human monoclonal antibody against the receptor activator of nuclear factor-κB ligand, has been shown to protect against AI-induced bone loss. However, the efficacy of denosumab in the treatment of AI-associated bone loss has not been prospectively evaluated in Japan. We prospectively monitored bone mineral density (BMD) of the lumbar spine and bilateral femoral necks in 100 postmenopausal women with hormone receptor-positive postoperative breast cancer of clinical stage I-IIIA in whom treatment with AI as adjuvant endocrine therapy was planned or had been ongoing...
November 7, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29112279/nutrients-intake-and-serum-calcium-and-phosphorus-levels-an%C3%A2-evidence-based-study
#8
Zahra Jafari Giv, Amir Avan, Farshid Hamidi, Maryam Tayefi, Sayyed Saeid Khayyatzadeh, Ali Javandoost, Mohsen Nematy, Gordon A Ferns, Majid Ghayour Mobarhan
INTRODUCTION: Dietary calcium and phosphorus appear to be important determinants of dyslipidemia and hypertension. We have investigated (1) the prevalence of hypocalcemia and hypophosphatemia in an Iranian population, and (2) the association between nutrient's intake and serum levels of calcium and phosphorus. METHODS: A total of 908 individuals were enrolled using a stratified-cluster sampling method from the Mashhad stroke and heart atherosclerosis disorder (MASHHAD) study...
November 7, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29108038/prepartum-daylight-exposure-increases-serum-calcium-concentrations-in-dairy-cows-at-the-onset-of-lactation
#9
R Özçelik, R M Bruckmaier, L E Hernández-Castellano
In dairy cows, hypocalcemia is caused by the sudden calcium demand by the mammary gland at the onset of lactation. Calcitriol (1,25-dihydroxy vitamin D; 1,25-VitD) increases the intestinal calcium absorption and the renal calcium reabsorption. Daylight contributes to the formation of 1,25-VitD, as it transforms 7-dehydrocholesterol into cholecalciferol, a 1,25-VitD precursor. Calving pens are usually set in quiet places where cows can stay calm and relaxed before parturition. However, those pens often have poor lighting conditions and therefore cows may become vitamin D deficient because of inadequate daylight exposure...
October 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/29103725/association-of-immediate-postpartum-plasma-calcium-concentration-with-early-lactation-clinical-diseases-culling-reproduction-and-milk-production-in-holstein-cows
#10
R C Neves, B M Leno, M D Curler, M J Thomas, T R Overton, J A A McArt
The objective of this study was to evaluate the association of postpartum plasma Ca concentration with early-lactation disease outcomes, culling within 60 d in milk, pregnancy to first service, and milk production. A total of 1,453 cows from 5 commercial dairy farms in New York State were enrolled in a prospective cohort study from February to November 2015. Blood samples were collected within 12 h of parturition, and plasma was submitted to a diagnostic laboratory for total Ca measurement. Early-lactation disease, reproductive performance, and milk production from Dairy Herd Improvement Association (DHIA) test-day data were compiled from each farm's management software...
November 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29101559/robotic-assisted-modified-radical-neck-dissection-using-a-bilateral-axillo-breast-approach-robotic-baba-mrnd-for-papillary-thyroid-carcinoma-with-lateral-lymph-node-metastasis
#11
Hyeong Won Yu, Young Jun Chai, Su-Jin Kim, June Young Choi, Kyu Eun Lee
BACKGROUND: Although safe in patients with papillary thyroid carcinoma (PTC), robotic thyroidectomy using a bilateral axillo-breast approach (BABA) has not been frequently performed in patients with advanced PTC. This study describes surgical outcomes in patients with PTC and lymph node metastasis (LNM) in lateral neck compartment who underwent robotic-assisted modified radical neck dissection with BABA (robotic BABA MRND). METHODS: The medical records of patients with PTC and lateral LNM who underwent robotic BABA MRND from March 2010 to July 2016 were retrospectively reviewed...
November 3, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29100453/preoperative-vitamin-d-deficiency-and-postoperative-hypocalcemia-in-thyroid-cancer-patients-undergoing-total-thyroidectomy-plus-central-compartment-neck-dissection
#12
Xiaofei Wang, Jingqiang Zhu, Feng Liu, Yanping Gong, Zhihui Li
Background: There appears to be a lack of consensus whether preoperative vitamin D deficiency (VDD) increases the risk of postoperative hypocalcemia and decreases the accuracy of postoperative parathyroid hormone (PTH) in predicting hypocalcemia in thyroid cancer patients undergoing total thyroidectomy (TT) plus central compartment neck dissection (CCND). This study aims to address these issues. Method: All consecutive thyroid cancer patients who underwent TT plus CCND were retrospectively reviewed through a prospectively collected database between October 2015 and April 2016 in a tertiary referral hospital...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29093531/intraoperative-assessment-of-parathyroid-viability-using-laser-speckle-contrast-imaging
#13
E A Mannoh, G Thomas, C C Solórzano, A Mahadevan-Jansen
Post-surgical hypoparathyroidism and hypocalcemia are known to occur after nearly 50% of all thyroid surgeries as a result of accidental disruption of blood supply to healthy parathyroid glands, which are responsible for regulating calcium. However, there are currently no clinical methods for accurately identifying compromised glands and the surgeon relies on visual assessment alone to determine if any gland(s) should be excised and auto-transplanted. Here, we present Laser Speckle Contrast Imaging (LSCI) for real-time assessment of parathyroid viability...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29078836/secondary-hyperparathyroidism-in-heart-failure
#14
REVIEW
Mohamed S Morsy, Dwight A Dishmon, Nadish Garg, Karl T Weber
Secondary hyperparathyroidism (SHPT) is a well-known pathophysiologic feature of chronic renal failure. In recent years, SHPT has become recognized as a complication of the aldosteronism associated with congestive heart failure and where excretory Ca(2+) and Mg(2+) wasting results in plasma-ionized hypocalcemia and hypomagnesemia. Elevations in plasma parathyroid hormone have adverse systemic consequences, including intracellular Ca(2+) overloading of myocytes and vascular smooth muscle with the induction of oxidative stress...
October 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29075541/unusual-complication-of-multidrug-resistant-tuberculosis
#15
Prerna Sharma, Ravindra Nath Sahay
INTRODUCTION: Capreomycin is a second-line drug often used for multidrug-resistant tuberculosis which can result in nephrotoxic effects similar to other aminoglycosides. We describe a case of capreomycin induced Bartter-like syndrome with hypocalcemic tetany. CASE REPORT: 23-year-old female patient presented with carpopedal spasms and tingling sensations in hands. Patient was being treated with capreomycin for two months for tuberculosis. On further investigation, hypocalcemia, hyponatremia, hypomagnesemia, hypokalemia, and hypochloremic metabolic alkalosis were noted...
2017: Case Reports in Nephrology
https://www.readbyqxmd.com/read/29074836/-update-on-recent-progress-in-vitamin-d-research-vitamin-d-treatment-for-hypoparathyroidism
#16
Masanori Minagawa
The patients with hypoparathyroidism have been treated with active vitamin D(ie, alfacalcidol and calcitriol). Parathyroid hormone(PTH)increases extracellular calcium concentration partly through the activation of vitamin D, and active vitamin D corrects hypocalcemia mainly by increasing intestinal calcium abosorption. PTH coordinately increases blood calcium level with vitamin D in bone and kidney, however, renal tubular reabsorption of calcium is regulated by PTH-dependent mechanism. Hypercalciuria is an complication of long-term vitamin D treatment for PTH-deficient hypoparathyroidism...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29074834/-update-on-recent-progress-in-vitamin-d-research-the-role-of-vitamin-d-in-management-of-ckd-mbd
#17
Naoto Hamano, Masafumi Fukagawa
Vitamin D was originally discovered as a substance which alleviates rickets and studies revealed that vitamin D exerts pleiotropic effects. Vitamin D has a therapeutic effect on Chronic Kidney Disease(CKD)-associated bone lesion or secondary hyperparathyroidism. On the other hand, excessive vitamin D induces calcium and phosphate overload, resulting in vascular calcification and cardiovascular events. From the data so far, not all CKD patients can get the benefit of vitamin D. It is well indicated for CKD patients with vitamin D insufficiency, secondary parathyroidism, hypocalcemia, or low-turnover bone disease on the basis of avoiding calcium over load...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29074833/-update-on-recent-progress-in-vitamin-d-research-vitamin-d-insufficiency-deficiency
#18
Ryo Okazaki
Serum 25(OH)D level reflects bodily vitamin D store. Recently published "Assessment criteria for vitamin D deficiency/insufficiency in Japan" defines vitamin D sufficiency as 25(OH)D level of 30 ng/mL or more, vitamin D insufficiency as that of 20 to 30 ng/mL, vitamin D deficiency as that of less than 20 ng/mL. The lower the serum 25(OH)D level is, the higher the risks are, of secondary hyperparathyroidism, low bone mineral density, fall, fracture, rickets/osteomalacia, and hypocalcemia, as well as lower response to anti-osteoporosis medications...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29073906/hdr-syndrome-with-a-novel-mutation-in-gata3-mimicking-a-congenital-x-linked-stapes-gusher-a-case-report
#19
Aram Yang, Jinsup Kim, Chang-Seok Ki, Sung Hwa Hong, Sung Yoon Cho, Dong-Kyu Jin
BACKGROUND: Hypoparathyroidism, sensorineural hearing loss, and renal disease (HDR) syndrome, also known as Barakat syndrome, is a rare genetic disorder with high phenotypic heterogeneity caused by haploinsufficiency of the GATA3 gene on chromosome 10p14-p15. For these reasons, the diagnosis of HDR syndrome is challenging and requires a high index of suspicion as well as genetic analysis. CASE PRESENTATION: A 14-month-old boy, with sensorineural hearing loss in both ears, showed typical radiological features of X-linked stapes gusher on preoperative temporal bone computed tomography (CT) for cochlear implantations...
October 26, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/29066572/time-to-parathyroid-function-recovery-in-patients-with-protracted-hypoparathyroidism-after-total-thyroidectomy
#20
Inés Villarroya-Marquina, Juan Sancho, Leyre Lorente-Poch, Lander Gallego-Otaegui, Antonio Sitges-Serra
OBJECTIVE: Hypocalcemia is the most common adverse effect after total thyroidectomy. It recovers in about two thirds of the patients within the first postoperative month. Little is known, however, about recovery of the parathyroid function (RPF) after this time-period. The aim of the present study was to investigate the time to RPF in patients with protracted (>1 month) hypoparathyroidism after total thyroidectomy. DESIGN: Cohort prospective observational study Methods: Adult patients undergoing total thyroidectomy for goitre or thyroid cancer...
October 24, 2017: European Journal of Endocrinology
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