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https://www.readbyqxmd.com/read/29451848/mr-imaging-of-atraumatic-muscle-disorders
#1
Edward Smitaman, Dyan V Flores, Catalina Mejía Gómez, Mini N Pathria
Atraumatic disorders of skeletal muscles include congenital variants; inherited myopathies; acquired inflammatory, infectious, or ischemic disorders; neoplastic diseases; and conditions leading to muscle atrophy. These have overlapping appearances at magnetic resonance (MR) imaging and are challenging for the radiologist to differentiate. The authors organize muscle disorders into four MR imaging patterns: (a) abnormal anatomy with normal signal intensity, (b) edema/inflammation, (c) mass, and (d) atrophy, highlighting each of their key clinical and imaging findings...
February 16, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29448967/facial-nerve-stimulation-in-normal-pigs-and-healthy-human-volunteers-transitional-development-of-a-medical-device-for-the-emergency-treatment-of-ischemic-stroke
#2
Olivia Sanchez, Andrea García, Fernando Castro-Prado, Miriam Perez, Rafael Lara-Estrada, Martin Ramirez-Meza, Montserrat Godinez, Michael L Coco, Joaquín Azpiroz, Mark K Borsody, Emilio Sacristán
BACKGROUND: Magnetic stimulation of the facial nerve has been tested in preclinical studies as a new, non-invasive emergency treatment of ischemic stroke that acts by increasing cerebral blood flow (CBF). The objective of the studies reported herein was to identify minimal stimulation parameters that increase CBF in large animals and then test those stimulation parameters in healthy volunteers for safety, tolerability, and effectiveness at increasing CBF. This translational research is necessary preparation for clinical studies in ischemic stroke patients...
February 15, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29439123/endovascular-thrombectomy-in-wake-up-stroke-and-stroke-with-unknown-symptom-onset
#3
P Bücke, M Aguilar Pérez, V Hellstern, M AlMatter, H Bäzner, H Henkes
BACKGROUND AND PURPOSE: Mechanical thrombectomy in acute ischemic stroke within 6 hours of symptom onset is effective and safe. However, in many patients, information on the beginning of symptoms is not available. Patients can be divided into those with wake-up stroke and daytime-unwitnessed stroke. Evidence on outcome and complications after mechanical thrombectomy in wake-up stroke and daytime-unwitnessed stroke is rare. A potential beneficial effect of mechanical thrombectomy in selected patients with wake-up stroke or daytime-unwitnessed stroke is suspected...
February 8, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29408682/neurochemical-changes-in-unilateral-cerebralhemisphere-during-the-subacute-stage-of-focal-cerebral-ischemia-reperfusion-in-rats-an-ex-vivo-1h-magnetic-resonance-spectroscopy-study
#4
Qun Huang, Chen Li, Nengzhi Xia, Liangcai Zhao, Dan Wang, Yunjun Yang, Hongchang Gao
Understanding the subacute may shed light on the mechanism of cerebral ischemia. The present study aimed to explore metabolic features underlying subacute stage of ischemia-reperfusion injury and developing effective treatments. Rats were divided into three groups: the permanent middle cerebral artery occlusion (pMCAO), transient cerebral focal ischemia (tMCAO) and sham group. Evaluation of animal models was performed by the neurological deficit, MR images and pathological morphological abnormality. To elucidate metabolic changes, we conducted a comparative analysis of metabolic composition of unilateral brain tissue using 1H nuclear magnetic resonance spectroscopy...
January 31, 2018: Brain Research
https://www.readbyqxmd.com/read/29399763/significant-mitral-regurgitation-predicts-the-long-term-prognosis-in-patients-receiving-cardiac-resynchronization-therapy
#5
Han Jin, Shengwen Yang, Wei Hua, Min Gu, Hongxia Niu, Ligang Ding, Jing Wang, Cong Xue, Shu Zhang
BACKGROUND: Cardiac resynchronization therapy (CRT) has been shown to reduce Functional mitral regurgitation (FMR), although the relationship between significant mitral regurgitation (SMR) and the clinical prognosis of CRT remains uncertain. AIM: To investigate the association of baseline of SMR with long-term outcomes in patients undergoing CRT. METHODS: A total of 296 consecutive patients undergoing CRT were enrolled. SMR was quantified by color Doppler in all the patients at baseline and defined as grading scale ≥ 3...
February 5, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29391146/ischemic-mitral-regurgitation-abnormal-strain-overestimates-non-viable-myocardium
#6
Ashley E Morgan, Yue Zhang, Mehrzad Tartibi, Samantha Goldburg, Jiwon J Kim, Thanh D Nguyen, Julius Guccione, Liang Ge, Jonathan W Weinsaft, Mark B Ratcliffe
BACKGROUND: Therapy for moderate ischemic mitral regurgitation (IMR) remains unclear. Determination of myocardial viability, a necessary pre-requisite for an improvement in regional contractility, is a likely key factor in determining response to revascularization alone. Myocardial strain has been proposed as a viability measure but has not been compared to late gadolinium enhancement (LGE) cardiac (c)MRI. We hypothesized that abnormal strain overestimates non-viable LV segments measured using LGE and that ischemia and mechanical tethering by adjacent transmural myocardial infarction (TMI) also decreases strain in viable segments...
January 29, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29387972/effect-of-cardiac-resynchronization-therapy-on-mitral-valve-geometry-a-novel-aspect-as-reversed-mitral-remodeling
#7
Oguz Karaca, Beytullah Cakal, Mehmet Onur Omaygenc, Haci Murat Gunes, Filiz Kizilirmak, Sinem Deniz Cakal, Deniz Dilan Naki, Irfan Barutcu, Bilal Boztosun, Fethi Kilicaslan
Amelioration of the valvular geometry is a possible mechanism for mitral regurgitation (MR) improvement in patients receiving cardiac resynchronization therapy (CRT). We aimed to establish the precise definition, incidence, and predictors of reversed mitral remodeling (RMR), as well as the association with MR improvement and short-term CRT outcome. Ninety-five CRT recipients were retrospectively evaluated for the end-point of "MR response" defined as the absolute reduction in regurgitant volume (RegV) at 6 months...
January 31, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29385918/magnetic-resonance-guided-high-intensity-focused-ultrasound-sonolysis-potential-applications-for-stroke
#8
Adeel Ilyas, Ching-Jen Chen, Dale Ding, Andrew Romeo, Thomas J Buell, Tony R Wang, M Yashar S Kalani, Min S Park
Stroke is one of the leading causes of death worldwide and a significant source of long-term morbidity. Unfortunately, a substantial number of stroke patients either are ineligible or do not significantly benefit from contemporary medical and interventional therapies. To address this void, investigators recently made technological advances to render transcranial MR-guided, high-intensity focused ultrasound (MRg-HIFU) sonolysis a potential therapeutic option for both acute ischemic stroke (AIS)-as an alternative for patients with emergent large-vessel occlusion (ELVO) who are ineligible for endovascular mechanical thrombectomy (EMT) or as salvage therapy for patients in whom EMT fails-and intracerebral hemorrhage (ICH)-as a neoadjuvant means of clot lysis prior to surgical evacuation...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29367688/mitral-valve-annuloplasty-versus-replacement-for-severe-ischemic-mitral-regurgitation
#9
Baotong Li, Shanglin Chen, Hansong Sun, Jianping Xu, Yunhu Song, Wei Wang, Shuiyun Wang
Although practice guidelines recommend surgery for patients with severe chronic ischemic mitral regurgitation (CIMR), they do not specify whether to repair or replace the mitral valve. 436 consecutive patients with severe CIMR were eligible for inclusion in the study, of which 316 (72.5%) underwent mitral valve annuloplasty (MVA) whereas 120 (27.5%) received mitral valve replacement (MVR). At 59 months (interquartile range, 37-85 months) follow-up, though the left ventricle end-diastolic diameter was markedly larger (P = 0...
January 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29365017/association-of-reperfusion-with-brain-edema-in-patients-with-acute-ischemic-stroke-a-secondary-analysis-of-the-mr-clean-trial
#10
W Taylor Kimberly, Bruna Garbugio Dutra, Anna M M Boers, Heitor C B R Alves, Olvert A Berkhemer, Lucie van den Berg, Kevin N Sheth, Yvo B W E M Roos, Aad van der Lugt, Ludo F M Beenen, Diederik W J Dippel, Wim H van Zwam, Robert J van Oostenbrugge, Hester F Lingsma, Henk Marquering, Charles B L M Majoie
Importance: It is uncertain whether therapeutic reperfusion with endovascular treatment yields more or less brain edema. Objective: To elucidate the association between reperfusion and brain edema. The secondary objectives were to evaluate whether brain edema could partially be responsible for worse outcomes in patients with later reperfusion or lower Alberta Stroke Program Early Computed Tomography Score. Design, Setting, and Participants: This was a post hoc analysis of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN), which was a prospective, randomized, multicenter clinical trial of endovascular treatment compared with conventional care of patients with acute anterior circulation ischemic stroke...
January 24, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29362285/-rapid-recanalization-of-cerebral-venous-sinus-thrombosis-secondary-to-severe-dehydration-a-case-report
#11
Ichiro Kawahara, Keisuke Toyoda, Makoto Hirose, Naoki Kitagawa
A 41-year-old healthy man presented with sudden disturbance of consciousness and convulsion during a marathon. Computed tomography revealed a lateral sinus sign in the posterior fossa, and magnetic resonance(MR)venography revealed a flow gap in the posterior part of the superior sagittal sinus and bilateral transverse sinus, although the other MR image sequences were normal. Laboratory data revealed dehydration, acute kidney failure, and rhabdomyolysis. Owing to immediate correction of dehydration, clinical symptoms and radiological abnormality improved rapidly...
January 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29351787/scl20a2-mutation-presenting-with-acute-ischemic-stroke-a-case-report
#12
Xiaoyu Zhang, Gaoting Ma, Zhangning Zhao, Meijia Zhu
BACKGROUND: Primary familial brain calcification (PFBC) is a rare disorder characterized by distinctive bilateral brain calcification and variable clinical presentations. However, cerebrovascular attack was rarely reported in PFBC patients. We here reported a SLC20A2 mutation patient presenting with acute ischemic stroke. CASE PRESENTATION: A 56 years old man was transferred to our hospital because of 6 days of melena and 3 days of somnolence, agitation and mood changes...
January 19, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29342431/comparison-of-access-type-on-perioperative-outcomes-after-endovascular-aortic-aneurysm-repair
#13
Jeffrey J Siracuse, Alik Farber, Jeffrey A Kalish, Douglas W Jones, Denis Rybin, Gheorghe Doros, Salvatore T Scali, Marc L Schermerhorn
OBJECTIVE: Endovascular aneurysm repair (EVAR) can be performed through percutaneous or surgical access. Our goal was to assess the difference in perioperative outcomes based on access type in a real-world setting. METHODS: The Vascular Quality Initiative (VQI) database was queried for EVAR. Univariable analysis and multivariable analysis were used to determine the independent effect of access type. RESULTS: There were 8340 (64%) and 4747 (36%) EVAR procedures performed through percutaneous and surgical access (3395 [72%] transverse and 1352 [28%] vertical incisions)...
January 13, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29342024/clinical-profile-of-patients-with-heart-failure-can-predict-rehospitalization-and-quality-of-life
#14
Michele Di Mauro, Renata Petroni, Daniela Clemente, Massimiliano Foschi, Fabrizio Tancredi, Virginia Camponetti, Sabina Gallina, Antonio M Calafiore, Maria Penco, Silvio Romano
BACKGROUND: The aim of this retrospective study was to identify clinical, humoral and echocardiographic variables predicting rehospitalization and poor quality of life (QOL) in patients with reduced or mid-range ejection fraction heart failure. METHODS: From 2009 to 2012, 310 patients were admitted having signs and symptoms of heart failure with reduced ejection fraction. All the patients were followed by phone, calling the patients or the referring general practitioner...
March 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29326139/carotid-artery-wall-imaging-perspective-and-guidelines-from-the-asnr-vessel-wall-imaging-study-group-and-expert-consensus-recommendations-of-the-american-society-of-neuroradiology
#15
L Saba, C Yuan, T S Hatsukami, N Balu, Y Qiao, J K DeMarco, T Saam, A R Moody, D Li, C C Matouk, M H Johnson, H R Jäger, M Mossa-Basha, M E Kooi, Z Fan, D Saloner, M Wintermark, D J Mikulis, B A Wasserman
Identification of carotid artery atherosclerosis is conventionally based on measurements of luminal stenosis and surface irregularities using in vivo imaging techniques including sonography, CT and MR angiography, and digital subtraction angiography. However, histopathologic studies demonstrate considerable differences between plaques with identical degrees of stenosis and indicate that certain plaque features are associated with increased risk for ischemic events. The ability to look beyond the lumen using highly developed vessel wall imaging methods to identify plaque vulnerable to disruption has prompted an active debate as to whether a paradigm shift is needed to move away from relying on measurements of luminal stenosis for gauging the risk of ischemic injury...
January 11, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29326138/cerebellar-hypoperfusion-in-migraine-attack-incidence-and-significance
#16
F Kellner-Weldon, M El-Koussy, S Jung, M Jossen, P P Klinger-Gratz, R Wiest
BACKGROUND AND PURPOSE: Patients diagnosed with migraine with aura have an increased lifetime risk of ischemic stroke. It is not yet clear whether prolonged cortical hypoperfusion during an aura increases the immediate risk of cerebellar infarction because it may induce crossed cerebellar diaschisis and subsequent tissue damage. To address this question, we retrospectively analyzed potential relationships between cortical oligemia and cerebellar hypoperfusion in patients with migraine with aura and their potential relation to small infarct-like cerebellar lesions...
January 11, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29326137/expression-changes-in-lactate-and-glucose-metabolism-and-associated-transporters-in-basal-ganglia-following-hypoxic-ischemic-reperfusion-injury-in-piglets
#17
Y Zheng, X-M Wang
BACKGROUND AND PURPOSE: The neonatal brain has active energy metabolism, and glucose oxidation is the major energy source of brain tissue. Lactate is produced by astrocytes and released to neurons. In the central nervous system, lactate is transported between neurons and astrocytes via the astrocyte-neuron lactate shuttle. The aim of this study was to investigate the regulatory mechanisms of energy metabolism in neurons and astrocytes in the basal ganglia of a neonatal hypoxic-ischemic brain injury piglet model...
January 11, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29321337/associations-between-collateral-status-and-thrombus-characteristics-and-their-impact-in-anterior-circulation-stroke
#18
Heitor C Alves, Kilian M Treurniet, Bruna G Dutra, Ivo G H Jansen, Anna M M Boers, Emilie M M Santos, Olvert A Berkhemer, Diederik W J Dippel, Aad van der Lugt, Wim H van Zwam, Robert J van Oostenbrugge, Hester F Lingsma, Yvo B W E M Roos, Albert J Yoo, Henk A Marquering, Charles B L M Majoie
BACKGROUND AND PURPOSE: Thrombus characteristics and collateral score are associated with functional outcome in patients with acute ischemic stroke. It has been suggested that they affect each other. The aim of this study is to evaluate the association between clot burden score, thrombus perviousness, and collateral score and to determine whether collateral score influences the association of thrombus characteristics with functional outcome. METHODS: Patients with baseline thin-slice noncontrast computed tomography and computed tomographic angiography images from the MR CLEAN trial (Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands) were included (n=195)...
January 10, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29321236/midregional-proatrial-natriuretic-peptide-improves-risk-stratification-after-ischemic-stroke-association-with-mortality-and-cardioembolic-etiology
#19
Gian Marco De Marchis, Juliane Schneider, Anja Weck, Felix Fluri, Joachim Fladt, Christian Foerch, Beat Mueller, Andreas Luft, Mirjam Christ-Crain, Marcel Arnold, Mira Katan
OBJECTIVE: To validate midregional proatrial natriuretic peptide (MR-proANP) for outcome prediction and diagnosis of cardioembolic stroke etiology compared to established clinical variables. METHODS: In this prospective multicenter cohort study, we quantified MR-proANP levels in ischemic stroke patients within 24 hours of onset. Primary outcome measures were 90-day mortality, unfavorable functional outcome (modified Rankin Scale score >2), and cardioembolic stroke etiology diagnosed during hospitalization...
January 10, 2018: Neurology
https://www.readbyqxmd.com/read/29321130/exercise-hemodynamic-and-functional-capacity-after-mitral-valve-replacement-in-patients-with-ischemic-mitral-regurgitation-a-comparison-of-mechanical-versus-biological-prostheses
#20
Carlo Fino, Attilio Iacovoni, Philippe Pibarot, John R Pepper, Paolo Ferrero, Maurizio Merlo, Lorenzo Galletti, Massimo Caputo, Paolo Ferrazzi, Constantinos Anagnostopoulos, Diego Cugola, Michele Senni, Diego Bellavia, Julien Magne
BACKGROUND: In patients with ischemic mitral regurgitation requiring mitral valve replacement (MVR), the choice of the prosthesis type is crucial. The exercise hemodynamic and functional capacity performance in patients with contemporary prostheses have never been investigated. To compare exercise hemodynamic and functional capacity between biological (MVRb) and mechanical (MVRm) prostheses. METHODS AND RESULTS: We analyzed 86 consecutive patients with ischemic mitral regurgitation who underwent MVRb (n=41) or MVRm (n=45) and coronary artery bypass grafting...
January 2018: Circulation. Heart Failure
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