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https://www.readbyqxmd.com/read/28813816/computational-rehabilitation-of-neglect-using-state-space-models-to-understand-the-recovery-mechanisms
#1
Giulia Sedda, Marcella Ottonello, Elena Fiabane, Caterina Pistarini, Anna Sedda, Vittorio Sanguineti
Unilateral spatial neglect is a neuropsychological syndrome often observed in right hemisphere stroke patients. The symptoms differ from subject to subject. A few rehabilitation approaches, e.g. prism adaptation, have demonstrated some effect in reducing the symptoms, but the underlying mechanisms are still largely unclear. Recently, neural models have been proposed to qualitatively describe cortical lesions, the resulting neglect symptoms and the effects of treatment. However, these predictions are qualitative and cannot be used to compare different hypotheses or to interpret symptoms at individual subjects level...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28808889/interactions-between-myocardial-sympathetic-denervation-and-left-ventricular-mechanical-dyssynchrony-a-czt-analysis
#2
Alessia Gimelli, Riccardo Liga, Francesca Menichetti, Ezio Soldati, Maria Grazia Bongiorni, Paolo Marzullo
BACKGROUND: A correlation between left ventricular (LV) dyssynchrony (LVD) and impaired myocardial sympathetic tone has been hypothesized. We sought to assess the interactions between regional LV sympathetic innervation, perfusion, and mechanical dyssynchrony. METHODS: Eighty-three patients underwent evaluation of LV perfusion and sympathetic innervation on (99m)Tc-tetrofosmin/(123)I-metaiodobenzylguanidine ((123)I-MIBG) imaging. The summed rest score and summed (123)I-MIBG score (SS-MIBG) were computed...
August 14, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28808575/reduced-ventilation-perfusion-v-q-mismatch-following-endobronchial-valve-insertion-demonstrated-by-gallium-68-v-q-photon-emission-tomography-computed-tomography
#3
Paul Leong, Pierre-Yves Le Roux, Jason Callahan, Shankar Siva, Michael S Hofman, Daniel P Steinfort
Endobronchial valves (EBVs) are increasingly deployed in the management of severe emphysema. Initial studies focussed on volume reduction as the mechanism, with subsequent improvement in forced expiratory volume in 1 s (FEV1). More recent studies have emphasized importance of perfusion on predicting outcomes, though findings have been inconsistent. Gallium-68 ventilation-perfusion (V/Q) photon emission tomography (PET)/computed tomography (CT) is a novel imaging modality with advantages in spatial resolution, quantitation, and speed over conventional V/Q scintigraphy...
September 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28807778/cervical-cord-canal-mismatch-a-new-method-for-identifying-predisposition-to-spinal-cord-injury
#4
REVIEW
Aria Nouri, Julio Montejo, Xin Sun, Justin Virojanapa, Luis E Kolb, Khalid M Abbed, Joseph Cheng
The risk for spinal cord injuries (SCIs) ranging from devastating traumatic injuries, compression due to degenerative pathology, and neurapraxia is increased in patients with congenital spinal stenosis. Classical diagnostic criteria include an absolute anteroposterior diameter of <12-13mm or a Torg-Pavlov Ratio of <0.80-0.82; however, these factors do not take into account the size of the spinal cord, which varies across patients independent of canal size. Recent large MRI studies of population cohorts have allowed newer methods to emerge that account for both cord and canal size by measuring a spinal cord occupation ratio (SCOR)...
August 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28807769/reduced-intensity-haploidentical-bone-marrow-transplantation-with-post-transplant-cyclophosphamide-for-solid-tumors-in-pediatric-and-young-adult-patients
#5
Nicolas J Llosa, Kenneth R Cooke, Allen Chen, Christopher Gamper, Orly Klein, Elias Zambidis, Brandon Luber, Gary Rosner, Nicholas Siegel, Mary Jo Holuba, Nancy Robey, Masanori Hayashi, Richard J Jones, Ephraim Fuchs, Matthias Holdhoff, David M Loeb, Heather J Symons
High risk, recurrent, or refractory solid tumors in pediatric, adolescent and young adult (AYA) patients have an extremely poor prognosis despite current intensive treatment regimens. We piloted an allogeneic bone marrow transplant (alloBMT) platform using a reduced intensity conditioning (RIC) and partially HLA-mismatched (haploidentical) related donors for this population of pediatric and AYA solid tumor patients. Sixteen patients received a fludarabine, cyclophosphamide (Cy), melphalan and low dose total body irradiation (TBI) RIC haploidentical BMT (haploBMT) followed by post-transplantation cyclophosphamide (PTCy), mycophenolate mofetil (MMF) and sirolimus...
August 11, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28807768/the-ebmt-risk-score-predicts-the-outcome-of-patients-with-acute-leukemia-receiving-single-umbilical-cord-blood-transplantation
#6
Xiaoyu Zhu, Lulu Huang, Changcheng Zheng, Baolin Tang, Huilan Liu, Liangquan Geng, Juan Tong, Lei Zhang, Xuhan Zhang, Wen Yao, Kaidi Song, Xingbing Wang, Kaiyang Ding, Zimin Sun
The European Group for Blood and Marrow Transplantation (EBMT) risk score has been implemented as an important tool to predict patient outcomes following allogeneic haematopoietic stem cell transplantation (allo-HSCT). However, to our knowledge, this score has never been applied in cases of single umbilical cord blood transplantation (sUCBT). We retrospectively analyzed 207 consecutive patients with acute leukemia who received sUCBT at our centre between February 2011 and December 2015. The probability of 3-year overall survival (OS) and leukemia-free survival (LFS) of the entire cohort were 65...
August 11, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28806335/a-smartphone-application-for-customized-frequency-table-selection-in-cochlear-implants
#7
Daniel Jethanamest, Mahan Azadpour, Annette M Zeman, Elad Sagi, Mario A Svirsky
HYPOTHESIS: A novel smartphone-based software application can facilitate self-selection of frequency allocation tables (FAT) in postlingually deaf cochlear implant (CI) users. BACKGROUND: CIs use FATs to represent the tonotopic organization of a normal cochlea. Current CI fitting methods typically use a standard FAT for all patients regardless of individual differences in cochlear size and electrode location. In postlingually deaf patients, different amounts of mismatch can result between the frequency-place function they experienced when they had normal hearing and the frequency-place function that results from the standard FAT...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28805995/germline-pms2-and-somatic-poleexo-mutations-cause-hypermutability-of-the-leading-dna-strand-in-biallelic-mismatch-repair-deficiency-syndrome-brain-tumors
#8
Andrianova Maria, Ghati Kasturirangan Chetan, Madathan Kandi Sibin, Thomas Mckee, Doron Merkler, Rao Kvl Narasinga, Pascale Ribaux, Jean-Louis Blouin, Periklis Makrythanasis, Vladimir B Seplyarskiy, Stylianos E Antonarakis, Sergey I Nikolaev
Biallelic Mismatch Repair Deficiency (bMMRD) in tumors is frequently associated with somatic mutations in the exonuclease domains of DNA polymerases POLE or POLD1 and results to a characteristic mutational profile. In this study we describe the genetic basis of ultramutated high grade brain tumors in the context of bMMRD. We performed exome sequencing of two second-cousin patients from a large consanguineous family of Indian origin with early onset of high grade glioblastoma and astrocytoma. We identified a germline homozygous nonsense variant R802X in the PMS2 gene...
August 14, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28804617/-typical-chiropractic-patients-can-they-be-described-in-terms-of-recovery-patterns
#9
Iben Axén, Charlotte Leboeuf-Yde
BACKGROUND: Chiropractors expect the typical patient to recover fully or to improve quickly with treatment if relapses occur. However, a mismatch between expectations and outcome would have a negative effect on both the chiropractors' professional self-esteem and patients' satisfaction with care. The prevalence of three types of recovery patterns among patients with non-specific low back pain (LBP) was calculated: 1: A full sustained recovery. 2: Initial recovery, but with one or several relapses followed by a period of recovery...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/28801654/perceptions-of-asthma-control-in-the-united-kingdom-a-cross-sectional-study-comparing-patient-and-healthcare-professionals-perceptions-of-asthma-control-with-validated-act-scores
#10
Andrew Menzies-Gow, Gavin Chiu
Perceptions of asthma control often vary between patients and physicians. This cross-sectional survey provided UK-specific data on actual and perceived asthma control in patients (18-75 years) attending routine asthma reviews in primary, secondary and tertiary settings. Differences between healthcare professionals' (HCP) and patients' perceptions of asthma control were evaluated via an online questionnaire and compared to a control-the validated asthma control test (ACT)-which patients completed. Treated patients (at least a short acting ß-agonist) with a documented diagnosis of asthma were enroled and consented within a month of their last appointment...
August 11, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28801307/loss-of-mutl-disrupts-chk2-dependent-cell-cycle-control-through-cdk4-6-to-promote-intrinsic-endocrine-therapy-resistance-in-primary-breast-cancer
#11
Svasti Haricharan, Nindo Punturi, Purba Singh, Kimberly R Holloway, Meenakshi Anurag, Jacob Schmelz, Cheryl Schmidt, Jonathan T Lei, Vera Suman, Kelly Hunt, John A Olson, Jeremy Hoog, Shunqiang Li, Shixia Huang, Dean P Edwards, Shyam M Kavuri, Matthew N Bainbridge, Cynthia X Ma, Matthew J Ellis
Significant endocrine therapy-resistant tumor proliferation is present in ≥20% of estrogen receptor positive (ER+) primary breast cancers and is associated with disease recurrence and death. Here, we uncover a link between intrinsic endocrine therapy resistance and dysregulation of the MutL mismatch repair complex (MLH1/3, PMS1/2), and demonstrate a direct role for MutL complex loss in resistance to all classes of endocrine therapy. We find that MutL deficiency in ER+ breast cancer abrogates Chk2-mediated inhibition of CDK4, a prerequisite for endocrine therapy responsiveness...
August 11, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28800468/the-mmn-as-a-viable-and-objective-marker-of-auditory-development-in-ci-users
#12
REVIEW
Risto Näätänen, Bjørn Petersen, Ritva Torppa, Eila Lonka, Peter Vuust
In the present article, we review the studies on the use of the mismatch negativity (MMN) as a tool for an objective assessment of cochlear-implant (CI) functioning after its implantation and as a function of time of CI use. The MMN indexes discrimination of different sound stimuli with a precision matching with that of behavioral discrimination and can therefore be used as its objective index. Importantly, these measurements can be reliably carried out even in the absence of attention and behavioral responses and therefore they can be extended to populations that are not capable of behaviorally reporting their perception such as infants and different clinical patient groups...
July 20, 2017: Hearing Research
https://www.readbyqxmd.com/read/28797715/universal-point-of-care-testing-for-lynch-syndrome-in-patients-with-upper-tract-urothelial-carcinoma
#13
Michael J Metcalfe, Firas G Petros, Priya Rao, Maureen E Mork, Lianchun Xiao, Russell R Broaddus, Surena F Matin
BACKGROUND: Patients with Lynch syndrome (LS) are at risk for upper tract urothelial carcinoma (UTUC). We aim to identify the most reliable means of point-of-care (POC) screening for LS in UTUC patients. METHODS: From January 2013 through July 2016, 115 consecutive UTUC patients without a history of LS were universally screened during their follow-up. We evaluated patient/family history (Amsterdam criteria I [AMS1] and II [AMS2]), tumor immunohistochemistry (IHC) for mismatch repair proteins (MMRP), and microsatellite instability (MSI)...
August 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28796011/the-nature-and-natural-history-of-posterior-cortical-atrophy-syndrome-a-variant-of-early-onset-alzheimer-disease
#14
Peter K Panegyres, Judy Goh, Michael McCarthy, Andrew I Campbell
A prospective longitudinal evaluation of 12 patients over a 16-year interval using clinical neurological and imaging data to determine whether posterior cortical atrophy syndrome (PCA) related to early-onset Alzheimer disease (AD) and to examine its natural history. Our 12 patients had a median age of onset of 56 years (range, 48 to 63 y) and were followed for a median of 6 years (range, 3 to 9 y). Patients either presented with complex visual phenomena or developed them with time. Six patients underwent flurodeoxyglucose and Pittsburgh investigational compound B imaging which showed a mismatch between metabolic activity and amyloid deposition with reduced metabolism in parieto-occipital regions on flurodeoxyglucose positron emission tomography and diffuse neocortical uptake of amyloid without occipital predominance...
August 8, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28795426/blinded-histopathological-characterisation-of-pole-exonuclease-domain-mutant-endometrial-cancers-sheep-in-wolf-s-clothing
#15
Inge C Van Gool, Jef E H Ubachs, Ellen Stelloo, Cor D de Kroon, Jelle J Goeman, Vincent T H B M Smit, Carien L Creutzberg, Tjalling Bosse
AIMS: POLE exonuclease domain mutations identify a subset of endometrial cancer (EC) patients with an excellent prognosis. Implementation of this biomarker has been suggested to refine adjuvant treatment decisions, but the necessary sequencing is not widely performed and relatively expensive. Therefore, we aimed to identify histopathological and immunohistochemical characteristics to aid the detection of POLE-mutant ECs. METHODS AND RESULTS: Fifty-one POLE-mutant endometrioid, 67 POLE-wild-type endometrioid and 15 POLE-wild-type serous ECs were included (total N=133)...
August 10, 2017: Histopathology
https://www.readbyqxmd.com/read/28793134/clinical-and-genetic-implications-of-dna-mismatch-repair-deficiency-in-patients-with-pancreatic-ductal-adenocarcinoma
#16
Jordan M Cloyd, Matthew H G Katz, Huamin Wang, Amanda Cuddy, Y Nancy You
No abstract text is available yet for this article.
August 9, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28792651/regret-about-surgical-decisions-among-early-stage-breast-cancer-patients-effects-of-the-congruence-between-patients-preferred-and-actual-decision-making-roles
#17
Ashley Wei-Ting Wang, Su-Mei Chang, Cheng-Shyong Chang, Shou-Tung Chen, Dar-Ren Chen, Fang Fan, Michael H Antoni, Wen-Yau Hsu
OBJECTIVE: Early-stage breast cancer patients generally receive either a mastectomy or a lumpectomy, either by their own choice or that of their surgeon. Sometimes there is regret about the decision afterward. To better understand regret about surgical decisions, this study examined two possibilities: The first is that women who take a dominant or collaborative role in decision- making about the surgery express less regret afterward. The second is that congruence between preferred role and actual role predicts less regret...
August 9, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28791060/outcome-of-single-piece-intraocular-lens-sulcus-implantation-following-posterior-capsular-rupture-during-phacoemulsification
#18
Masomeh Mohebbi, Seyed Ali Bashiri, Seyed Farzad Mohammadi, Behnaz Samet, Fariba Ghassemi, Elham Ashrafi, Fatemeh Bazvand
PURPOSE: To assess the safety and outcome of single-piece posterior chamber intraocular lens (PC-IOL) implantation in the ciliary sulcus following posterior capsular rupture during cataract surgery. METHODS: Patients with posterior capsular rupture during cataract surgery with a single-piece acrylic IOL implanted into the ciliary sulcus were studied. Complete ocular examinations were performed after 6 months postoperatively. RESULTS: Twenty-four eyes were included...
July 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28790115/msh2-loss-in-primary-prostate-cancer
#19
Liana Guedes, Emmanuel S Antonarakis, Michael T Schweizer, Nooshin Mirkheshti, Fawaz Almutairi, Jong Chul Park, Stephanie A Glavaris, Jessica L Hicks, Mario A Eisenberger, Angelo M De Marzo, Jonathan I Epstein, William B Isaacs, James R Eshleman, Colin C Pritchard, Tamara L Lotan
PURPOSE: Inactivation of mismatch repair (MMR) genes may predict sensitivity to immunotherapy in metastatic prostate cancers. We studied primary prostate tumors with MMR defects. EXPERIMENTAL DESIGN: 1133 primary prostatic adenocarcinomas and 43 prostatic small cell carcinomas (NEPC) were screened by MSH2 immunohistochemistry with confirmation by next-generation sequencing (NGS). Microsatellite instability (MSI) was assessed by PCR and NGS (mSINGS). RESULTS: Of primary adenocarcinomas and NEPC, 1...
August 8, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28789661/reference-free-determination-of-tissue-absorption-coefficient-by-modulation-transfer-function-characterization-in-spatial-frequency-domain
#20
Weiting Chen, Huijuan Zhao, Tongxin Li, Panpan Yan, Kuanxin Zhao, Caixia Qi, Feng Gao
BACKGROUND: Spatial frequency domain (SFD) measurement allows rapid and non-contact wide-field imaging of the tissue optical properties, thus has become a potential tool for assessing physiological parameters and therapeutic responses during photodynamic therapy of skin diseases. The conventional SFD measurement requires a reference measurement within the same experimental scenario as that for a test one to calibrate mismatch between the real measurements and the model predictions. Due to the individual physical and geometrical differences among different tissues, organs and patients, an ideal reference measurement might be unavailable in clinical trials...
August 8, 2017: Biomedical Engineering Online
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