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Fecal microbiota transplantation

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https://www.readbyqxmd.com/read/28077694/laboratory-testing-of-donors-and-stool-for-fecal-microbiota-transplantation-for-recurrent-c-difficile-infection
#1
Michael H Woodworth, Emma M Neish, Nancy S Miller, Tanvi Dhere, Eileen M Burd, Cynthia Carpentieri, Kaitlin L Sitchenko, Colleen S Kraft
Fecal microbiota transplantation is an efficacious and inexpensive therapy for recurrent Clostridium difficile, yet its safety is thought to depend on appropriate fecal donor screening. FDA guidance for regulation of this procedure is in flux but screening and manufacture of fecal material from asymptomatic donors presents many challenges to clinical laboratories. This minireview summarizes FDA regulatory changes, principles of donor selection and recommended laboratory screening for fecal microbiota transplantation...
January 11, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28077203/clostridium-difficile-infection-in-older-adults-systematic-review-of-efforts-to-reduce-occurrence-and-improve-outcomes
#2
Leisa L Marshall, Samuel Peasah, Gregg A Stevens
OBJECTIVE: Provide a systematic review of the primary literature on efforts to reduce Clostridium difficile infection (CDI) occurrence and improve outcomes in older adults. DATA SOURCES, STUDY SELECTION, DATA EXTRACTION: PubMed and CINAHL databases were searched for research studies using search terms CDI, CDI prevention, reduction, control, management, geriatric, elderly, adults 65 years of age and older. The MeSH categories Aged and Aged, 80 and older, were used...
January 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28068341/exploring-the-efficacy-of-pooled-stools-in-fecal-microbiota-transplantation-for-microbiota-associated-chronic-diseases
#3
Abbas Kazerouni, Lawrence M Wein
Fecal microbiota transplantation is being assessed as a treatment for chronic microbiota-related diseases such as ulcerative colitis. Results from an initial randomized trial suggest that remission rates depend on unobservable features of the fecal donors and observable features of the patients. We use mathematical modeling to assess the efficacy of pooling stools from different donors during multiple rounds of treatment. In the model, there are two types of patients and two types of donors, where the patient type is observable and the donor type (effective or not effective) is not observable...
2017: PloS One
https://www.readbyqxmd.com/read/28059612/fecal-microbial-transplantation-as-a-therapeutic-option-in-patients-colonized-with-antibiotic-resistant-organisms
#4
Michael Laffin, Braden Millan, Karen L Madsen
Despite increasing interest in fecal microbiota transplantation (FMT), its full therapeutic potential has yet to be determined. Since its increase in popularity, FMT has been shown to be highly effective in the treatment of both Clostridium difficile infection (CDI) and its recurrent form. Interest in FMT now expands well beyond the treatment of CDI to other processes with known associations to the microbiota such as antibiotic resistant infections, inflammatory bowel disease (IBD), hepatic encephalopathy, neuropsychiatric disorders, and metabolic disease...
January 6, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28050036/irritable-bowel-syndrome-like-symptoms-following-fecal-microbiota-transplantation-a-possible-donor-dependent-complication
#5
Bianca W Chang, Ali Rezaie
No abstract text is available yet for this article.
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28042926/the-potential-impact-of-gut-microbiota-on-your-health-current-status-and-future-challenges
#6
Stitaya Sirisinha
Our health and probably also our behaviors and mood depend not only on what we eat or what we do (lifestyle behaviors), but also on what we host. It is well established for decades that all vertebrates including humans are colonized by a wide array of bacteria, fungi, eukaryotic parasites and viruses, and that, at steady state (homeostasis), this community of microbes establishes a friendly mutual relationship with the host. The term microbiota was originally meant to represent an ecological community of commensals and potentially pathogenic microbes that live within our bodies, but it is now used interchangeably with the term microbiome which was initially meant to represent a collective genome of the microbiota...
December 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28042242/perceptions-of-fecal-microbiota-transplantation-for-clostridium-difficile-infection-factors-that-predict-acceptance
#7
Leslie Park, Anjali Mone, Jennifer C Price, Demetrios Tzimas, Jacqueline Hirsh, Michael A Poles, Lisa Malter, Lea Ann Chen
BACKGROUND: Despite the effectiveness of fecal microbiota transplantation (FMT) for treating recurrent Clostridium difficile (C. difficile) infection, some patients are reluctant to accept this therapy. Our study examined attitudes towards FMT and factors that contribute to patients' acceptance of this treatment. METHODS: We distributed patient surveys at a Veterans Affairs hospital, a public hospital, and an academic faculty practice. Multivariable logistic regression was performed, adjusting for factors associated with FMT acceptance on univariate analysis and prior experience with C...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28039159/gut-microbiota-differs-between-children-with-inflammatory-bowel-disease-and-healthy-siblings-in-taxonomic-and-functional-composition-a-metagenomic-analysis
#8
Rebecca Luise Knoll, Kristoffer Forslund, Jens Roat Kultima, Claudius U Meyer, Ulrike Kullmer, Shinichi Sunagawa, Peer Bork, Stephan Gehring
Current treatment for pediatric IBD patients is often ineffective, with serious side effects. Manipulating the gut microbiota via fecal microbiota transplantation (FMT) is an emerging treatment approach but remains controversial. We aimed to assess the composition of the fecal microbiome through a comparison of pediatric IBD patients to their healthy siblings, evaluating risks and prospects for FMT in this setting. A Case-Control (Sibling) Study was conducted analyzing fecal samples of six children with Crohn's Disease (CD), six children with Ulcerative Colitis (UC) and 12 healthy siblings by metagenomic sequencing...
December 30, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28027582/fecal-microbiota-transplantation-induces-hbeag-clearance-in-patients-with-positive-hbeag-after-long-term-antiviral-therapy
#9
Yan-Dan Ren, Zhen-Shi Ye, Liu-Zhu Yang, Li-Xin Jin, Wen-Jun Wei, Yong-Yue Deng, Xiao-Xiao Chen, Chuan-Xing Xiao, Xiao-Fang Yu, Hong-Zhi Xu, Li-Zhu Xu, Yun-Na Tang, Fei Zhou, Xue-Lian Wang, Mei-Ya Chen, Li-Gang Chen, Mei-Zhu Hong, Jian-Lin Ren, Jin-Shui Pan
No abstract text is available yet for this article.
December 27, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28011612/oral-vancomycin-followed-by-fecal-transplantation-versus-tapering-oral-vancomycin-treatment-for-recurrent-clostridium-difficile-infection-an-open-label-randomized-controlled-trial
#10
Susy S Hota, Valerie Sales, George Tomlinson, Mary Jane Salpeter, Allison McGeer, Bryan Coburn, David S Guttman, Donald E Low, Susan M Poutanen
BACKGROUND: Fecal transplantation (FT) is a promising treatment for recurrent Clostridium difficile infection (CDI), but its true effectiveness remains unknown. We compared 14 days of oral vancomycin followed by a single FT by enema with oral vancomycin taper (standard of care) in adult patients experiencing acute recurrence of CDI. METHODS: In a phase 2/3, single-center, open-label trial, participants from Ontario, Canada, experiencing recurrence of CDI were randomly assigned in a 1:1 ratio to 14 days of oral vancomycin treatment followed by a single 500-mL FT by enema, or a 6-week taper of oral vancomycin...
November 9, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28011611/fecal-fixation-fecal-microbiota-transplantation-for-clostridium-difficile-infection
#11
EDITORIAL
Stuart Johnson, Dale N Gerding
No abstract text is available yet for this article.
November 9, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28008842/-microbiota-and-representations-of-the-human-body
#12
Betty Dodet
Although the presence of an intestinal flora has been known for a long time, the discovery of the role of gut microbiota in human health and disease has been widely recognized as one of the most important advances in the recent years. Chronic diseases may result from dysbiosis, i.e. a disruption of the balance within the bacterial population hosted by the human body. These developments open new prospects in terms of prevention and treatment, including the design of adapted diets, the development of functional foods and fecal transplantation...
November 2016: M├ędecine Sciences: M/S
https://www.readbyqxmd.com/read/28008840/-fecal-microbiota-transplantation-indications-and-perspectives
#13
Jean-Christophe Lagier, Didier Raoult
Fecal transplantation demonstrated in a randomized trial its superiority compared to antibiotics in recurrent Clostridium difficile (CD) infections. Used in first-line treatment, it has reduced the mortality of patients suffering of CD infections caused by ribotype 027 and made it possible to cure patients with severe manifestations of CD infections caused by other ribotypes. The use of frozen microbiota, now validated, facilitates fecal microbiota transplantation. In addition, the frozen microbiota capsules have proven their efficiency...
November 2016: M├ędecine Sciences: M/S
https://www.readbyqxmd.com/read/28001467/fecal-microbiota-transplant-in-severe-and-severe-complicated-clostridium-difficile-a-promising-treatment-approach
#14
Monika Fischer, Brian Sipe, Yao-Wen Cheng, Emmalee Phelps, Nicholas Rogers, Sashidhar Sagi, Matthew Bohm, Huiping Xu, Zain Kassam
Severe and severe-complicated Clostridium difficile infection (CDI) is associated with high morbidity and mortality. Colectomy is standard of care; however, post-operative mortality rates approach 50%. Case reports suggest fecal microbiota transplant (FMT) is a promising treatment for severe and severe-complicated disease but there is a paucity of data. Here, we present a single center experience with a novel sequential FMT protocol for patients refractory to maximal medical therapy. This approach consists of at least one FMT delivered via colonoscopy with criteria for repeat FMT and continued vancomycin therapy based on clinical response and pseudomembranes...
December 21, 2016: Gut Microbes
https://www.readbyqxmd.com/read/28000680/pretreatment-with-antibiotics-may-enhance-the-efficacy-of-fecal-microbiota-transplantation-in-ulcerative-colitis-a-meta-analysis
#15
A H Keshteli, B Millan, K L Madsen
No abstract text is available yet for this article.
December 21, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/28000190/-short-term-efficacy-on-fecal-microbiota-transplantation-combined-with-soluble-dietary-fiber-and-probiotics-in-the-treatment-of-slow-transit-constipation
#16
Xiaolong Ge, Chao Ding, Jianfeng Gong, Hongliang Tian, Yao Wei, Qiyi Chen, Lili Gu, Ning Li
OBJECTIVE: To evaluate the efficacy and safety of fecal microbiota transplantation (FMT) combined with soluble dietary fiber and probiotics for slow transit constipation(STC). METHODS: Twenty-three patients with STC from Jinling Hospital, Medical School of Nanjing University were prospectively enrolled between April 2015 and January 2016. STC patients received FMT combined with soluble dietary fiber and probiotics. Fresh stool(100 g) was immediately mixed in a blender with 500 ml of 0...
December 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27999162/complete-microbiota-engraftment-is-not-essential-for-recovery-from-recurrent-clostridium-difficile-infection-following-fecal-microbiota-transplantation
#17
Christopher Staley, Colleen R Kelly, Lawrence J Brandt, Alexander Khoruts, Michael J Sadowsky
: Bacterial communities from subjects treated for recurrent Clostridium difficile infection (rCDI) by fecal microbiota transplantation (FMT), using either heterologous donor stool samples or autologous stool samples, were characterized by Illumina next-generation sequencing. As previously reported, the success of heterologous FMT (90%) was superior to that of autologous FMT (43%) (P = 0.019), and post-FMT intestinal bacterial communities differed significantly between treatment arms (P < 0...
December 20, 2016: MBio
https://www.readbyqxmd.com/read/27997976/the-microbiome-what-will-the-future-hold
#18
Howard Paul Monsour, Eamonn M M Quigley
Current research on the human microbiome has opened our eyes to the intimate relationship that we have with the bacteria that populate our gastrointestinal tract and its potential relationship to health and disease. To date, clinical research on the microbiome has identified intriguing associations between an altered microbiome and disease states, but proven therapeutic applications have been very limited. The ingestion of prebiotics, probiotics, and/or synbiotics is appealing to the general public and has significant commercial value, but as yet, solid evidence for clinical efficacy in liver disease has been lacking due, in large part, to the paucity of high-quality clinical trials...
September 2016: Seminars in Liver Disease
https://www.readbyqxmd.com/read/27997974/the-microbiome-and-primary-sclerosing-cholangitis
#19
Ahmad H Ali, Elizabeth J Carey, Keith D Lindor
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with detrimental sequela. In many patients, PSC progresses to end-stage liver disease and hepatobiliary cancer. There is no medical therapy that is proven to halt or reverse the progression of PSC. Approximately 70 to 80% of PSC patients have inflammatory bowel disease, usually ulcerative colitis. The etiology of PSC is poorly understood. Several lines of evidence suggest that the intestinal microbiota plays an important role in the etiopathogenesis of PSC...
September 2016: Seminars in Liver Disease
https://www.readbyqxmd.com/read/27997854/the-emerging-metabolic-view-of-clostridium-difficile-pathogenesis
#20
REVIEW
Andrew J Hryckowian, Kali M Pruss, Justin L Sonnenburg
It is widely accepted that Clostridium difficile exploits dysbiosis and leverages inflammation to thrive in the gut environment, where it can asymptomatically colonize humans or cause a toxin-mediated disease ranging in severity from frequent watery diarrhea to pseudomembranous colitis or toxic megacolon. Here, we synthesize recent findings from the gut microbiota and enteric pathogenesis fields to inform the next steps toward a better understanding of C. difficile infection (CDI). In this review, we present a model in which the lifestyle of C...
December 17, 2016: Current Opinion in Microbiology
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