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Multi drug resistant bacteria

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https://www.readbyqxmd.com/read/29151895/toll-like-receptor-4-differentially-mediates-intestinal-and-extra-intestinal-immune-responses-upon-multi-drug-resistant-pseudomonas-aeruginosa-association-of-il10-mice-with-chronic-colitis
#1
Anne Grunau, Ulrike Escher, Anja A Kühl, Stefan Bereswill, Markus M Heimesaat
Background: Infections with multi-drug resistant (MDR) Gram-negative bacteria including Pseudomonas aeruginosa (PA) have become a serious threat particularly in hospitalized patients with immunopathological co-morbidities. The well-balanced interplay between immune cells, pattern recognition receptors such as Toll-like receptor (TLR)-4 sensing lipopolysaccharide from Gram-negative bacteria including PA, and evolving pathways is crucial to prevent the host from invading (opportunistic) pathogens...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/29151063/predation-among-microorganisms-a-huge-potential-of-interspecies-dependencies
#2
Justyna Kowalska, Marcin Włodarczyk
There are many interactions between species (including bacteria) in the environment. One of them is predation, which always leads to the death of a prey. Described in this review Bdellovibrio bacteriovorus (Deltaproteobacteria) and Micavibrio aeruginosavorus (Alfaproteobacteria) are uniflagellate, rod shaped and curved obligate predators of Gram-negative bacteria. Both species belong to the group of BALOs (Bdellovibrio and like organisms). B. bacteriovorus use periplasmic predatory strategy and M. aeruginosavorus are epibiotic hunters...
November 3, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29138446/antimicrobial-resistance-and-genetic-diversity-in-ceftazidime-non-susceptible-bacterial-pathogens-from-ready-to-eat-street-foods-in-three-taiwanese-cities
#3
Lin Lin, Sheng-Fan Wang, Tsung-Ying Yang, Wei-Chun Hung, Min-Yu Chan, Sung-Pin Tseng
Bacterial contamination of ready-to-eat (RTE) street foods is a major concern worldwide. Dissemination of antibiotic resistant pathogens from food is an emerging public-health threat. To investigate the prevalence of antibiotic resistance genes and ceftazidime resistance-associated efflux pumps in foodborne pathogens, 270 RTE street foods samples were collected in three densely populated Taiwanese cities. Among 70 ceftazidime non-susceptible isolates, 21 Stenotrophomonas maltophilia, 12 Pseudomonas spp., 22 Acinetobacter spp...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138082/synthesis-of-chitosan-alginate-cs-alg-microspheres-with-high-antimicrobial-and-antibiofilm-activity-against-multi-drug-resistant-microbial-pathogens
#4
Rajagopalan Thaya, Baskaralingam Vaseeharan, Jeyachandran Sivakamavalli, Arokiadhas Iswarya, Marimuthu Govindarajan, Naiyf S Alharbi, Shine Kadaikunnan, Mohammed N Al-Anbr, Jamal M Khaled, Giovanni Benelli
The successful treatment of multi-drug resistant microbial pathogens represents a major challenge for public health management. Here, chitosan-alginate (CS/ALG) microspheres with narrow size distribution were fabricated by ionically cross linking method using Ca(2+) ions as agents for polymer solidification. The physicochemical properties of CS/ALG microspheres, such as surface morphology and size were studied by SEM and the functional group interactions were confirmed by Fourier transform infrared (FTIR) spectroscopy...
November 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29137627/prevalence-of-current-patterns-and-predictive-trends-of-multidrug-resistant-salmonella-typhi-in-sudan
#5
Ayman A Elshayeb, Abdelazim A Ahmed, Marmar A El Siddig, Adil A El Hussien
BACKGROUND: Enteric fever has persistence of great impact in Sudanese public health especially during rainy season when the causative agent Salmonella enterica serovar Typhi possesses pan endemic patterns in most regions of Sudan - Khartoum. OBJECTIVES: The present study aims to assess the recent state of antibiotics susceptibility of Salmonella Typhi with special concern to multidrug resistance strains and predict the emergence of new resistant patterns and outbreaks...
November 14, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/29135264/peptide-based-polymer-polyoxometalate-supramolecular-structure-with-differed-antimicrobial-mechanism
#6
Lakshmi Priya Datta, Riya Mukherjee, Subharanjan Biswas, Tapan Kumar Das
Because of the increasing prevalence of multi-drug resistance feature, several investigations have been so far reported regarding the antibiotic alternative supramolecular bioactive agents made of hybrid assemblies. In this regard, it is well established that combinational therapy inherited by assembled supramolecular structures can improve the bioactivity to some extent but their mode of actions have not been studied in details. We provide the first direct evidence that the improved mechanism of action of antimicrobial supra-amphiphilic nanocomposites differ largely from their parent antimicrobial peptide based polymers...
November 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29118410/the-microbiological-characteristics-and-risk-factors-for-picc-related-bloodstream-infections-in-intensive-care-unit
#7
Shumin Zhang, Xiaofeng Sun, Yan Lei
The study was aimed to investigate the pathogens distribution and risk factors for PICC-related bloodstream infection in intensive care unit (ICU) patients. 402 patients placed with PICC in ICU were recruited in the study. The microbiological characteristics of PICC-related infection were investigated by Vitek 2 Compact automated microbial system. Antibiotics sensitivity was performed with disk diffusion and minimum inhibitory concentration (MIC) methods. Multivariate logistic and cox analyses were performed to identify the risk factors for PICC-related infection in ICU patients...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29116010/multi-drug-resistance-and-extended-spectrum-beta-lactamase-producing-gram-negative-bacteria-from-chicken-meat-in-bharatpur-metropolitan-nepal
#8
Anil Shrestha, Anup Muni Bajracharya, Hemraj Subedi, Raju Shah Turha, Sachin Kafle, Saroj Sharma, Sunil Neupane, Dhiraj Kumar Chaudhary
OBJECTIVE: Multidrug resistance (MDR) and extended spectrum beta lactamase (ESBL) producer Gram negative bacteria are considered as a major health problem, globally. ESBL enzyme hydrolyses the beta lactam ring of third generation cephalosporins, which alters the structure of the antibiotic. Due to the modification in structure of the antibiotic, bacteria show resistance to these antibiotics. Resistant bacterial strains are transmitted to humans from animals through consumption of uncooked meat, through contact with uncooked meat and meat surfaces...
November 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29111435/pharmacodynamics-of-cefiderocol-a-novel-siderophore-cephalosporin-explored-in-a-pseudomonas-aeruginosa-neutropenic-murine-thigh-model
#9
Islam M Ghazi, Marguerite L Monogue, Masakatsu Tsuji, David P Nicolau
BACKGROUND: Cefiderocol is a siderophore cephalosporin that displays potent in vitro activity against multi-drug resistant (MDR) Gram-negative bacteria. We aimed to describe cefiderocol's pharmacokinetics, pharmacodynamics, and 24-hour efficacy using dose-ranging methods in the neutropenic murine thigh infection model. METHODS: Infection was established in neutropenic mice (administered cyclophosphamide 150 mg/kg and 100 mg/kg 4 and 1 days prior to inoculation respectively) with 8 Pseudomonas aeruginosa isolates (MIC range: 0...
October 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29111434/empiric-treatment-of-lower-urinary-tract-infections-in-the-face-of-spreading-multi-drug-resistance-in-vitro-study-of-nitroxoline-effectiveness
#10
A Sobke, O Makarewicz, M Baier, C Bär, W Pfister, S G Gatermann, M W Pletz, C Forstner
The spread of antimicrobial resistance challenges the empiric treatment in urinary tract infections (UTI). Among others, nitrofurantoin is recommended for first line treatment, but acceptance among clinicians is limited due to chronic nitrofurantoin-induced lung toxicity and insufficient coverage of Enterobacteriaceae other than Escherichia coli. Nitroxoline seems to be an alternative to nitrofurantoin due to its favourable safety profile but data on its current in vitro susceptibility are sparse. In this study susceptibility to nitroxoline was tested against 3,012 urinary clinical isolates (including multidrug-resistant bacteria and Candida spp...
October 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29109849/current-concepts-and-future-strategies-in-the-antimicrobial-therapy-of-emerging-gram-positive-spontaneous-bacterial-peritonitis
#11
REVIEW
Marco Fiore, Alberto Enrico Maraolo, Ivan Gentile, Guglielmo Borgia, Sebastiano Leone, Pasquale Sansone, Maria Beatrice Passavanti, Caterina Aurilio, Maria Caterina Pace
Spontaneous bacterial peritonitis (SBP) is the most common infection in end-stage liver disease patients. SBP is defined as an ascitic fluid infection with a polymorphonuclear leucocyte count ≥ 250/mm(3) without an evident intra-abdominal surgically treatable source. Several mechanisms contribute to SBP occurrence, including translocation of gut bacteria and their products, reduced intestinal motility provoking bacterial overgrowth, alteration of the gut's barrier function and local immune responses. Historically, Gram-negative enteric bacteria have been the main causative agents of SBP, thereby guiding the empirical therapeutic choice...
October 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/29107747/vanillin-selectively-modulates-the-action-of-antibiotics-against-resistant-bacteria
#12
Camila Fonseca Bezerra, Cicera Janaine Camilo, Maria Karollyna do Nascimento Silva, Thiago Sampaio de Freitas, Jaime Ribeiro-Filho, Henrique Douglas Melo Coutinho
The treatment of infections caused by microorganisms that are resistant to antibiotics represent one of the main challenges of medicine today, especially due to the inefficacy of long-term drug therapy. In the search for new alternatives to treat these infections, many researchers have been looking for new substances derived from natural products to replace, or be used in combination with conventional antibiotics. Vanillin is a phenolic compound whose antimicrobial activity has been used in the elimination of pathogens present in fruits and vegetables...
October 28, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29091031/inter-species-population-dynamics-enhance-microbial-horizontal-gene-transfer-and-spread-of-antibiotic-resistance
#13
Robert M Cooper, Lev Tsimring, Jeff Hasty
Horizontal gene transfer (HGT) plays a major role in the spread of antibiotic resistance. Of particular concern are Acinetobacter baumannii bacteria, which recently emerged as global pathogens, with nosocomial mortality rates reaching 19-54% (Centers for Disease Control and Prevention, 2013; Joly Guillou, 2005; Talbot et al., 2006). Acinetobacter gains antibiotic resistance remarkably rapidly (Antunes et al., 2014; Joly Guillou, 2005), with multi drug-resistance (MDR) rates exceeding 60% (Antunes et al., 2014; Centers for Disease Control and Prevention, 2013)...
November 1, 2017: ELife
https://www.readbyqxmd.com/read/29079323/fluoroquinolone-prophylaxis-in-haematological-cancer-patients-with-neutropenia-ecil-critical-appraisal-of-previous-guidelines
#14
Malgorzata Mikulska, Diana Averbuch, Frederic Tissot, Catherine Cordonnier, Murat Akova, Thierry Calandra, Marcello Ceppi, Paolo Bruzzi, Claudio Viscoli
OBJECTIVES: Fluoroquinolone (FQ) prophylaxis was recommended in 2005 by European Conference on Infections in Leukemia (ECIL) for patients with prolonged neutropenia. In consideration of a worldwide increase in antibiotic resistance, the issue of FQ prophylaxis during neutropenia was re-evaluated. METHODS: Literature review of randomised controlled trials (RCT) and observational studies published in years 2006-2014 was performed. Their results were analysed in meta-analysis...
October 25, 2017: Journal of Infection
https://www.readbyqxmd.com/read/29077053/differential-effect-of-newly-isolated-phages-belonging-to-pb1-like-phikz-like-and-luz24-like-viruses-against-multi-drug-resistant-pseudomonas-aeruginosa-under-varying-growth-conditions
#15
Simone Latz, Alex Krüttgen, Helga Häfner, Eva Miriam Buhl, Klaus Ritter, Hans-Peter Horz
In this study, we characterize three phages (SL1 SL2, and SL4), isolated from hospital sewage with lytic activity against clinical isolates of multi-drug resistant Pseudomonas aeruginosa (MDR-PA). The host spectrum ranged from 41% to 54%, with all three phages together covering 79% of all tested clinical isolates. Genome analysis revealed that SL1 (65,849 bp, 91 open reading frames ORFs) belongs to PB1-like viruses, SL2 (279,696 bp, 354 ORFs) to phiKZ-like viruses and SL4 (44,194 bp, 65 ORFs) to LUZ24-like viruses...
October 27, 2017: Viruses
https://www.readbyqxmd.com/read/29076938/gut-colonization-with-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-may-increase-disease-activity-in-biologic-naive-outpatients-with-ulcerative-colitis-an-interim-analysis
#16
Vita Skuja, Aleksejs Derovs, Katrina Pekarska, Dace Rudzite, Elvira Lavrinovica, Linda Piekuse, Inga Kempa, Zane Straume, Jelena Eglite, Aivars Lejnieks, Angelika Krumina, Rami Eliakim
BACKGROUND: Certain Enterobacteriaceae strains have been associated with the development of ulcerative colitis (UC). Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae are the most commonly found multi-drug-resistant (MDR) bacteria colonizing the gut in UC patients and might trigger a more severe disease activity in UC patients. OBJECTIVE: The aim of this study was to evaluate whether disease activity is higher in UC patients with gut colonization with ESBL-producing Enterobacteriaceae...
October 25, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29072532/antibacterial-efficacy-of-silver-nanoparticles-and-ethyl-acetate-s-metabolites-of-the-potent-halophilic-marine-bacterium-bacillus-cereus-a30-on-multidrug-resistant-bacteria
#17
Dhayalan Arul, Govindasamy Balasubramani, Velramar Balasubramanian, Thillainathan Natarajan, Pachiappan Perumal
Bacteria are generally responsible for the prevalence of several diseases and pathogenic bacteria are showing increasing resistance to different antibacterials. During the present study an extremophilic bacterium-A30 isolated from the marine waters was characterized and evaluated against four multi-drug resistant (MDR) pathogens, viz; Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The sensitivity pattern of the selected pathogens was tested with 31 antibiotics...
October 26, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/29071232/vancomycin-capped-with-silver-nanoparticles-as-an-antibacterial-agent-against-multi-drug-resistance-bacteria
#18
Mahsa Esmaeillou, Gholamreza Zarrini, Mohammad Ahangarzadeh Rezaee, Javid Shahbazi Mojarrad, Ali Bahadori
Purpose: Many antimicrobial medications are available to combat infections. However, the indiscriminate use of antibiotics has produced antibiotic resistance in the case of many bacterial pathogens. This study focuses on the development of nanoparticles (NPs) that enhance the in vitro antibiotic activity of vancomycin against multi-drug resistant (MDR) organisms. Methods: Spherical shaped thioglycolic acid-stabilized silver nanoparticles (TGA-AgNPs) were prepared by using a simple chemical reduction method...
September 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29065551/molecular-docking-and-screening-studies-of-new-natural-sortase-a-inhibitors
#19
Georgiana Nitulescu, Isabela Madalina Nicorescu, Octavian Tudorel Olaru, Anca Ungurianu, Dragos Paul Mihai, Anca Zanfirescu, George Mihai Nitulescu, Denisa Margina
To date, multi-drug resistant bacteria represent an increasing health threat, with a high impact on mortality, morbidity, and health costs on a global scale. The ability of bacteria to rapidly and permanently acquire new virulence factors and drug-resistance elements requires the development of new antimicrobial agents and selection of new proper targets, such as sortase A. This specific bacterial target plays an important role in the virulence of many Gram-positive pathogens, and its inhibition should produce a mild evolutionary pressure which will not favor the development of resistance...
October 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29051652/making-good-use-of-the-byproducts-of-cultivation-green-synthesis-and-antibacterial-effects-of-silver-nanoparticles-using-the-leaf-extract-of-blueberry
#20
Kun Li, Chenyu Ma, Tiancai Jian, Hushan Sun, Lei Wang, Hui Xu, Weihuan Li, Hongyan Su, Xianhao Cheng
In this study, we made an effort to use blueberry leaves extract as a reducing and a capping agent to biosynthesize silver nanoparticles (AgNPs). The successful formation of AgNPs was confirmed with UV-visible spectroscopy, transmission electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction. Furthermore, their antimicrobial activities against four kinds of multi drug resistant clinical pathogens and aquatic pathogens were investigated. The results showed that as-prepared AgNPs exhibited broad-spectrum antibacterial activities...
October 2017: Journal of Food Science and Technology
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