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Proliferative diabetic retinopathy

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https://www.readbyqxmd.com/read/29223225/poor-glycemic-control-as-a-risk-factor-for%C3%A2-pseudophakic-cystoid-macular-edema-in-patients-with-diabetes
#1
Petteri Ylinen, Ilkka Laine, Juha-Matti Lindholm, Raimo Tuuminen
PURPOSE: To specify the risk factors for pseudophakic cystoid macular edema (CME) in patients with diabetes. SETTING: Kymenlaakso Central Hospital, Unit of Ophthalmology, Kotka, Finland. DESIGN: Prospective case series. METHODS: Patients with type 1 or type 2 diabetes having routine cataract surgery were evaluated. Spectral-domain optical coherence tomography imaging was performed before surgery and 1 month postoperatively...
November 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29220127/vascular-endothelial-growth-factor-inhibition-for-proliferative-diabetic-retinopathy-et-tu-brute
#2
EDITORIAL
Jakob Grauslund
No abstract text is available yet for this article.
December 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29217386/early-worsening-of-diabetic-retinopathy-after-rapid-improvement-of-blood-glucose-control-in-patients-with-diabetes
#3
REVIEW
S Feldman-Billard, É Larger, P Massin
AIM: To review the frequency, importance of and risk factors for "early worsening of diabetic retinopathy" (EWDR) after rapid improvement of blood glucose in patients with diabetes. METHODS: This was a systematic review of key references (PubMed 1980-2016) and the current international recommendations for the above-mentioned topics. RESULTS: EWDR has been described during intensive treatment (IT) in patients with uncontrolled type 1 or 2 diabetes, and after pancreas transplantation or bariatric surgery...
November 11, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29217148/ethnic-differences-in-the-prevalence-and-risk-factors-of-diabetic-retinopathy-the-singapore-epidemiology-of-eye-diseases-study
#4
Gavin S Tan, Alfred Gan, Charumathi Sabanayagam, Yih Chung Tham, Kumari Neelam, Paul Mitchell, Jie Jin Wang, Ecosse L Lamoureux, Ching-Yu Cheng, Tien Y Wong
PURPOSE: To evaluate the prevalence and risk factors for diabetic retinopathy (DR) in the Singapore Epidemiology of Eye Diseases (SEED) Study. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: Persons of Malay, Indian, and Chinese ethnicity aged 40+ years, living in Singapore. METHODS: Diabetes was defined as nonfasting plasma glucose ≥200 mg/dl (11.1 mmol/l), glycated hemoglobin A1c (HbA1c) >6.5%, self-reported physician-diagnosed diabetes, or the use of glucose-lowering medication...
December 4, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29215958/postoperative-complications-of-pars-plana-vitrectomy-for-diabetic-retinal-disease
#5
Gary L Yau, Paolo S Silva, Paul G Arrigg, Jennifer K Sun
Despite recent advances in the medical management of diabetic retinal disease, there remain established indications for vitreoretinal surgery in the treatment of severe proliferative diabetic retinopathy. These include non-clearing vitreous hemorrhage and tractional retinal detachment. Advances in surgical instrumentation, technique, and experience have led to improved visual outcomes, as well as a corresponding decrease in the incidence of postoperative complications. However, the presence of systemic and ocular factors in diabetic patients increases the risk of adverse events compared to non-diabetic individuals...
December 7, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29211719/inhibition-of-soluble-epoxide-hydrolase-prevents-diabetic-retinopathy
#6
Jiong Hu, Sarah Dziumbla, Jihong Lin, Sofia-Iris Bibli, Sven Zukunft, Julian de Mos, Khader Awwad, Timo Frömel, Andreas Jungmann, Kavi Devraj, Zhixing Cheng, Liya Wang, Sascha Fauser, Charles G Eberhart, Akrit Sodhi, Bruce D Hammock, Stefan Liebner, Oliver J Müller, Clemens Glaubitz, Hans-Peter Hammes, Rüdiger Popp, Ingrid Fleming
Diabetic retinopathy is an important cause of blindness in adults, and is characterized by progressive loss of vascular cells and slow dissolution of inter-vascular junctions, which result in vascular leakage and retinal oedema. Later stages of the disease are characterized by inflammatory cell infiltration, tissue destruction and neovascularization. Here we identify soluble epoxide hydrolase (sEH) as a key enzyme that initiates pericyte loss and breakdown of endothelial barrier function by generating the diol 19,20-dihydroxydocosapentaenoic acid, derived from docosahexaenoic acid...
December 6, 2017: Nature
https://www.readbyqxmd.com/read/29207695/association-of-glycated-haemoglobin-and-serum-apolipoproteins-with-diabetic-retinopathy-an-indian-overview
#7
Bhasker Mukherjee, Sandeep Shankar, Rehan Ahmed, Kanchan Singh, Kapil Bhatia
Introduction: India is presently facing an epidemic of diabetes mellitus and the risks of chronic complications from the disease are associated with the duration of the disease as well as the degree of hyperglycaemia. Diabetic retinopathy is a known microvascular complication of diabetes mellitus and is the most common cause of blindness in the western countries.Apolipoproteins are the protein component of lipoproteins. Apart from acting as structural proteins, they also act as cofactors to various enzymes...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29204993/update-on-the-use-of-anti-vegf-intravitreal-therapies-for-retinal-vein-occulsions
#8
Yi Jiang, William F Mieler
The use of anti-vascular endothelial growth factor (VEGF) therapy in ophthalmology has profoundly changed our management and treatment of conditions such as cystoid macular edema, diabetic macular edema, choroidal neovascularization, and other proliferative retinopathies. Although initially used for the treatment of choroidal neovascularization in neovascular age-related macular degeneration, their application has spread rapidly for other indications as their outcomes have often outperformed previously existing treatments...
November 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29203232/thioredoxin-interacting-protein-deficiency-ameliorates-diabetic-retinal-angiogenesis
#9
Jialiang Duan, Chunyang Du, Yonghong Shi, Danyan Liu, Jingxue Ma
Diabetic retinopathy is the leading cause of blindness among working-aged adults around the world. Hyperglycemia and intraocular vascular endothelial growth factor (VEGF) over-accumulation are essential for the progression of diabetic retinopathy, which eventually results in proliferative diabetic retinopathy, characterized by pathologic angiogenesis and impaired vision. Thioredoxin-interacting protein (TXNIP) was highly induced in retinal endothelial cells under diabetic conditions. However, the role of TXNIP in diabetes-associated retinal angiogenesis remains elusive...
December 1, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29199229/mammalian-target-of-rapamycin-mtor-as-a-potential-therapeutic-target-in-pathological-ocular-angiogenesis
#10
Tsutomu Nakahara, Akane Morita, Rina Yagasaki, Asami Mori, Kenji Sakamoto
Pathological ocular angiogenesis is a causative factor of retinopathy of prematurity, proliferative diabetic retinopathy, and wet age-related macular degeneration. Vascular endothelial growth factor (VEGF) plays an important role in pathological angiogenesis, and anti-VEGF agents have been used to treat the ocular diseases that are driven by pathological angiogenesis. However, adverse effects associated with the blockade of VEGF signaling, including impairments of normal retinal vascular growth and retinal function, were suggested...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29199016/microvascular-disease-during-pregnancy-in-type-1-diabetes-is-associated-with-ambulatory-arterial-stiffness
#11
Ingvild Holm Tjessem, Hanine Fadel Mustafa Al-Far, Jens Fuglsang, Finn Friis Lauszus
OBJECTIVES: The objective of this study was to evaluate the association between the ambulatory arterial stiffness index (AASI) and markers of microvascular disease during pregnancy in women with type 1 diabetes. STUDY DESIGN: A total of 151 women with type 1 diabetes mellitus were recruited for repeat 24-h BP recordings thrice during pregnancy and once three months post partum. Fifty women without diabetes served as controls. The AASI and pulse pressure (PP) were computed from blood pressure recordings...
November 23, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29198552/increased-prevalence-of-proliferative-retinopathy-in-patients-with-acromegaly
#12
Tzu-En Wu, Harn-Shen Chen
BACKGROUND: This pilot study was carried to determine the prevalence of retinopathy, especially proliferative retinopathy, in patients with acromegaly. METHODS: We analyzed 43 acromegalic patients and 129 age- and gender-matched patients with type 2 diabetes. The retinopathy status was determined from the medical records based on the ophthalmologist consultations of patients with acromegaly. Color photographs of the macula- and disc-centered views were obtained at an angle of 45° with a fundus camera after pharmacologic-induced mydriasis in patients with type 2 diabetes...
November 30, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29193789/temporal-changes-in-retinal-vascular-parameters-associated-with-successful-panretinal-photocoagulation-in-proliferative-diabetic-retinopathy-a-prospective-clinical-interventional-study
#13
Thomas Lee Torp, Ryo Kawasaki, Tien Yin Wong, Tunde Peto, Jakob Grauslund
PURPOSE: We aimed to investigate changes in retinal vascular geometry over time after panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PDR). METHODS: Thirty-seven eyes with PDR were included. Wide-field fluorescein angiography (Optomap, Optos PLC., Dunfermline, Scotland, UK) was used to diagnose PDR at baseline and to assess activity at follow-up month three and six. At each time-point, a trained grader measured retinal vessel geometry on optic disc (OD) centred images using semiautomated software (SIVA, Singapore I Vessel Assessment, National University of Singapore, Singapore) according to a standardized protocol...
November 29, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29190249/comparison-of-3-mm-%C3%A3-3-mm-versus-6-mm-%C3%A3-6-mm-optical-coherence-tomography-angiography-scan-sizes-in-the-evaluation-of-non-proliferative-diabetic-retinopathy
#14
Joseph Ho, Kunny Dans, Qisheng You, Eric N Nudleman, William R Freeman
PURPOSE: To evaluate the utility of different optical coherence tomography angiography scan protocols in evaluating retinal changes in non-proliferative diabetic retinopathy. METHODS: Patients were imaged with the RTVue XR Avanti OCT 3 mm × 3 mm and 6 mm × 6 mm "Angio Retina" scan protocols. Ability to clearly delineate the foveal avascular zone (FAZ), FAZ remodeling, microaneurysms, capillary nonperfusion, motion, and doubling artifacts were evaluated. RESULTS: Forty-six eyes from 27 patients were enrolled...
November 22, 2017: Retina
https://www.readbyqxmd.com/read/29190236/apoptosis-and-angiofibrosis-in-diabetic-tractional-membranes-after-vascular-endothelial-growth-factor-inhibition-results-of-a-prospective-trial-report-no-2
#15
Chunhua Jiao, Dean Eliott, Christine Spee, Shikun He, Kai Wang, Robert F Mullins, David R Hinton, Elliott H Sohn
PURPOSE: We sought to characterize the angiofibrotic and apoptotic effects of vascular endothelial growth factor (VEGF)-inhibition on fibrovascular epiretinal membranes in eyes with traction retinal detachment because of proliferative diabetic retinopathy. METHODS: Membranes were excised from 20 eyes of 19 patients (10 randomized to intravitreal bevacizumab, 10 controls) at vitrectomy. Membranes were stained with antibodies targeting connective tissue growth factor (CTGF) or VEGF and colabeled with antibodies directed against endothelial cells (CD31), myofibroblasts, or retinal pigment epithelium markers...
November 22, 2017: Retina
https://www.readbyqxmd.com/read/29183104/prevalence-and-progression-rate-of-diabetic-retinopathy-in-type-2-diabetes-patients-in-correlation-with-the-duration-of-diabetes
#16
Margarete Voigt, Sebastian Schmidt, Thomas Lehmann, Benjamin Köhler, Christoph Kloos, UlrichA Voigt, Daniel Meller, Gunther Wolf, Ulrich A Müller, Nicolle Müller
Aims We examined prevalence and progression of retinopathy in dependence on diabetes duration in order to estimate the probability of progression. Patients/Methods In a retrospective cohort-analysis from an academic outpatient department of endocrinology and metabolic diseases we analyzed 17461 consultations of 4513 patients with DM2 from 1987 to 2014. 50.3% of the patients (n=2272) had at least one documented result of funduscopy. Results 25.8% of the patients had retinopathy (20.2% non-proliferative, 4.7% proliferative, 0...
November 28, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29179221/-vitreomacular-traction-following-anti-vegf-therapy-two-cases
#17
Sophie Helene Wallraf, Kristina Markova, Christos Haritoglou
Vitreomacular traction syndrome (VMTS) is defined as an incomplete or anomalous posterior vitreous detachment resulting in tractional forces at the macular region. In the context of anti-VEGF therapy, the formation of vitreoretinal traction has mainly been reported as a potential complication of VEGF inhibition in ischemic proliferative retinal disease, such as proliferative diabetic retinopathy. In this report, we present two patients who developed VMTS during anti-VEGF therapy for exudative age-related macular degeneration and diabetic macular edema...
November 27, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29177923/skin-autofluorescence-is-a-noninvasive-surrogate-marker-for-diabetic-microvascular-complications-and-carotid-intima-media-thickness-in-japanese-patients-with-type-2-diabetes-a-cross-sectional-study
#18
Keiji Yoshioka
INTRODUCTION: Advanced glycation end-products (AGEs) are known to play an important role in the pathogenesis of diabetic complications. Skin autofluorescence (AF), a marker of AGE accumulation in tissue, can be measured noninvasively using a skin AF reader. The present study aimed to evaluate the relationships of skin AF with diabetic microvascular complications and carotid intima-media thickness (IMT), a surrogate marker for atherosclerosis, in Japanese subjects with type 2 diabetes (T2D)...
November 24, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29177891/plasma-levels-of-hypoxia-regulated-factors-in-patients-with-age-related-macular-degeneration
#19
Zygoula Ioanna, Schori Christian, Grimm Christian, Barthelmes Daniel
PURPOSE: Various hypoxia-related proteins are differentially expressed in the retina and secreted to the vitreous and/or aqueous humor of patients affected by dry or neovascular age-related macular degeneration (nAMD). To determine whether these conditions alter concentrations of cytokines also in the systemic circulation, we measured plasma levels of six hypoxia-related proteins. METHODS: Plasma was prepared from EDTA blood that was collected from patients affected by dry AMD (n = 5), nAMD (n = 11), proliferative diabetic retinopathy (PDR; n = 9), and patients with an epiretinal membrane (ERM; n = 11)...
November 25, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29176525/nonhereditary-idiopathic-foveal-retinoschisis-associated-with-new-onset-proliferative-diabetic-retinopathy
#20
Alec L Amram, Clint Kellogg, Ahmed Elkeeb
PURPOSE: To present a case of idiopathic foveal retinoschisis in a patient with new-onset proliferative diabetic retinopathy. METHODS: Single case report. RESULTS: A 64-year-old African American man with Type 2 diabetes mellitus presented for a routine annual diabetic eye examination with mildly blurred vision at near and distance in the right eye. Fluorescein angiography demonstrated optic nerve leakage consistent with neovascularization of the disk but no leakage on or around the macula in the right eye...
November 22, 2017: Retinal Cases & Brief Reports
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