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Proliferative diabetic retinopathy

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https://www.readbyqxmd.com/read/29040917/enhanced-diffusometric-immunosensing-with-grafted-gold-nanoparticles-for-detection-of-diabetic-retinopathy-biomarker-tumor-necrosis-factor-%C3%AE
#1
Han-Sheng Chuang, Yu-Ju Chen, Hui-Pin Cheng
Diffusometry is sensitive to geometric changes of particles. Target antigens can be detected through diffusivity changes resulting from their immunoreactions by functionalizing particle surface with a specific antibody. Considering that Brownian motion is a self-driven phenomenon, diffusometric immunosensing features several characteristics, such as no-washing steps, rapid detection, high flexibility, and high sensitivity. Until recently, this technique has been applied to many biomedical fields, such as monitoring of microorganism motility and diagnosis of diseases with biomarkers...
October 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29040280/quantitative-analysis-of-neural-tissues-around-the-optic-disc-after-panretinal-photocoagulation-in-patients-with-diabetic-retinopathy
#2
Hyun Seung Yang, June-Gone Kim, Jae Bong Cha, Young In Yun, Jong Hoon Park, Jong Eun Woo
In this retrospective cross-sectional study, we quantitatively analyzed the tomographic features in the neural tissues around the optic disc in patients with diabetic retinopathy with and without panretinal photocoagulation. We analyzed 206 eyes, comprising 33 normal eyes in subjects without diabetes (group I), 30 eyes without diabetic retinopathy (group II), 66 eyes with non-proliferative diabetic retinopathy (group III), 45 eyes with panretinal photocoagulation (group IV), and 32 eyes with normal tension glaucoma (group V)...
2017: PloS One
https://www.readbyqxmd.com/read/29033535/differential-association-of-elevated-inflammatory-cytokines-with-postoperative-fibrous-proliferation-and-neovascularization-after-unsuccessful-vitrectomy-in-eyes-with-proliferative-diabetic-retinopathy
#3
Shigeo Yoshida, Yoshiyuki Kobayashi, Shintaro Nakao, Yukio Sassa, Toshio Hisatomi, Yasuhiro Ikeda, Yuji Oshima, Toshihiro Kono, Tatsuro Ishibashi, Koh-Hei Sonoda
BACKGROUND: Pars plana vitrectomy is the only treatment for advanced proliferative diabetic retinopathy (PDR). However, vitrectomy is not always successful despite current progress in vitreoretinal surgical techniques. The aim of our study was to investigate whether the vitreal concentrations of MCP-1, IL-6, IL-8, and VEGF are elevated after unsuccessful vitrectomy in patients with PDR and to investigate whether the altered levels of these cytokines are associated with the cause for the reoperation...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29031854/angptl-4-induces-diabetic-retinal-inflammation-by-activating-profilin-1
#4
Qianyi Lu, Peirong Lu, Wei Chen, Li Lu, Zhi Zheng
Diabetic retinopathy (DR), the most common cause of irreversible blindness in working-age adults, results in central vision loss that is caused by microvascular damage to the inner lining of the back of the eye, the retina. The aim of this work was to assess the temporal relationships between angiopoietin-like protein-4 (ANGPTL-4), a novel adipocytokine factor, and diabetic retinal inflammation and microvascular dysfunction. The downstream pathway(s) and upstream mediator(s) of ANGPTL-4 were then determined under high glucose (HG) conditions...
October 12, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29030794/vegf-a-gene-polymorphisms-and-responses-to-intravitreal-ranibizumab-treatment-in-patients-with-diabetic-macular-edema
#5
Mehmet Tetikoğlu, Zafer Yüksel, Serdar Aktas, Haci Murat Sağdik, Fatih Özcura
PURPOSE: To investigate the association between VEGF gene polymorphisms and the responses to treatment with intravitreal ranibizumab (IVR) in patients with diabetic macular edema (DME). METHODS: This prospective study, conducted at the Kutahya Dumlupinar University Faculty of Medicine, included 95 patients with DME that were treated with IVR and 32 patients without DME despite proliferative diabetic retinopathy (PDR). The participants were divided into three groups: DME with non-proliferative diabetic retinopathy, DME with PDR, and PDR without DME; patients with DME who were treated with IVR were further divided into two groups based on their response to the treatment...
October 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29023169/associations-of-physical-activity-and-sedentary-behaviour-with-vision-threatening-diabetic-retinopathy-in-indonesian-population-with-type-2-diabetes-mellitus-jogjakarta-eye-diabetic-study-in-the-community-joged-com
#6
D P Dharmastuti, A N Agni, F Widyaputri, S Pawiroranu, Z M Sofro, F S Wardhana, S Haryanto, T W Widayanti, S Kotha, P Gupta, M B Sasongko
PURPOSE: To investigate the association of physical activity (PA) and sedentary behaviour with diabetic retinopathy (DR) in type 2 diabetes adults. METHODS: A community-based cross-sectional study of adults with type 2 diabetes. DR was assessed from disc- and macula-centred fundus photograph, and categorised into mild, moderate non-proliferative DR (NPDR), and Vision-Threatening DR (VTDR). Worse eye was used to determine the person's DR severity. PA was assessed using WHO Global Physical Activity Questionnaire (GPAQ)...
October 12, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29020428/improvement-of-recalcitrant-diabetic-macular-edema-after-peritoneal-dialysis
#7
Sally S Ong, Akshay S Thomas, Sharon Fekrat
Nephropathy may be an independent and contributory risk factor for diabetic macular edema (DME). A 69-year-old man who had previously been treated with panretinal laser photocoagulation for proliferative diabetic retinopathy as well as with steroid and anti-vascular endothelial growth factor injections for DME declined additional treatment for the DME, which was worse in the right eye. The DME was observed without further treatment for the next 36 months. Despite well-controlled blood sugar, blood pressure, and lipid levels, the DME remained unchanged...
October 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28988899/diabetic-choroidopathy-choroidal-vascular-density-and-volume-in-diabetic-retinopathy-with-swept-source-optical-coherence-tomography
#8
Jay C Wang, Inês Laíns, Joana Providência, Grayson W Armstrong, Ana R Santos, Pedro Gil, João Gil, Katherine E Talcott, João H Marques, João Figueira, Demetrios G Vavvas, Ivana K Kim, Joan W Miller, Deeba Husain, Rufino Silva, John B Miller
PURPOSE: To compare choroidal vascular density (CVD) and volume (CVV) in diabetic eyes and controls, using en face swept-source optical coherence tomography (SS-OCT). DESIGN: Prospective cross-sectional study. METHODS: ▪▪▪ SETTING: Multicenter PATIENT POPULATION: 143 diabetic eyes - 27 with no diabetic retinopathy (DR), 47 with nonproliferative DR (NPDR), 51 with NPDR and diabetic macular edema (DME), and 18 with proliferative DR (PDR), and 64 age-matched non-diabetic control eyes...
October 5, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28984756/preoperative-photocoagulation-reduces-corneal-endothelial-cell-damage-after-vitrectomy-in-patients-with-proliferative-diabetic-retinopathy
#9
Jie Zhong, Jun Jia, Jiguo Yu, Liping Zhang, Yi Xiang
Proliferative diabetic retinopathy (PDR) is a severe complication of diabetes and is a leading cause of visual decline and irreversible blindness. So we designed this study to investigate retrospectively the effect of preoperative photocoagulation on corneal endothelial cells after vitrectomy in patients with PDR.The study included 52 eyes of 46 patients with PDR complicated with vitreous hemorrhage, who underwent vitrectomy. Patients were apportioned to a photocoagulation group (26 eyes/23 patients) or nonphotocoagulation group (26/23 patients), according to their history of preoperative photocoagulation...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28984743/arterial-oxygen-saturation-in-neovascularizations-in-proliferative-diabetic-retinopathy
#10
Toke Bek
PURPOSE: Retinal neovascularizations in proliferative diabetic retinopathy have been proposed to develop from larger retinal venules. However, angiographic evidence suggests that the new vessels may originate from both arterioles and venules, and the vitreous oxygen tension near retinal neovascularizations is similar to that of retinal arterioles. An assessment of the oxygen saturation in neovascularizations may help characterizing the vascular origin of these vessels in proliferative diabetic retinopathy...
October 3, 2017: Retina
https://www.readbyqxmd.com/read/28984741/foveal-retinal-neovascularization-in-proliferative-diabetic-retinopathy-assessment-by-optical-coherence-tomography-angiography
#11
Sakura Murakawa, Taiji Hasegawa, Hideki Koizumi, Ichiro Maruko, Tomohiro Iida
No abstract text is available yet for this article.
October 3, 2017: Retina
https://www.readbyqxmd.com/read/28979738/role-of-angiopoietins-and-tie-2-in-diabetic-retinopathy
#12
Nervana Khalaf, Hazem Helmy, Hany Labib, Iman Fahmy, Mona Abd El Hamid, Leqaa Moemen
OBJECTIVE: The aim of this study was to determine the serum levels of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), soluble vascular endothelial tyrosine kinase receptor (Tie-2) and vascular endothelial growth factor (VEGF), in the serum of type 2 diabetic patients having non-proliferative (NPDR) or proliferative diabetic retinopathy (PDR). METHODS: One hundred patients with type 2 diabetes mellitus were involved in this cross-sectional study. They were classified into 25 diabetic patients without retinopathy, 35 patients with NPDR and 40 PDR patients...
August 2017: Electronic Physician
https://www.readbyqxmd.com/read/28979089/long-term-evaluation-of-spontaneous-release-of-epiretinal-membrane-and-its-possible-pathogenesis
#13
Teruyo Kida, Seita Morishita, Masanori Fukumoto, Takaki Sato, Hidehiro Oku, Tsunehiko Ikeda
PURPOSE: To investigate the characteristics in spontaneous release of epiretinal membrane (ERM) during watchful waiting and to introduce a possible mechanism of pathogenesis as a photo essay. METHODS: Records from all patients with ERM were obtained from Osaka Medical College Hospital from January 2001 to October 2012. Visual acuity (VA), fundus photo, and optical coherence tomography (OCT) were reviewed using the medical records. For statistical analysis, VA measured with a Landolt chart was converted to the logarithm of the minimum angle of resolution (logMAR)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28978321/a-case-of-pseudoxanthoma-elasticum-with-proliferative-diabetic-retinopathy
#14
Keigo Kakurai, Maiko Hayashi, Kanako Yamada, Norihiko Ishizaki, Yumiko Yonemoto, Seita Morishita, Ryohsuke Kohmoto, Takaki Sato, Teruyo Kida, Tsunehiko Ikeda
BACKGROUND: To report the case of a patient with pseudoxanthoma elasticum (PXE) and proliferative diabetic retinopathy (PDR), and discuss the relationship between PXE and diabetic retinopathy (DR). CASE PRESENTATION: A 47-year-old man with PXE presented with angioid streaks and DR in both eyes, and bilateral panretinal photocoagulation was performed for treatment. Vitrectomy had previously been performed in his right eye for vitreous hemorrhage due to PDR. Systemic findings included multiple, discrete, symmetrical, small yellow papules bilaterally in the axilla and inguinal region...
October 4, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28973045/the-expression-of-the-slit-robo-signal-in-the-retina-of-diabetic-rats-and-the-vitreous-or-fibrovascular-retinal-membranes-of-patients-with-proliferative-diabetic-retinopathy
#15
Weiyan Zhou, Hongya Wang, Wenzhen Yu, Wankun Xie, Min Zhao, Lvzhen Huang, Xiaoxin Li
PURPOSE: The Slit-Robo signal has an important role in vasculogenesis and angiogenesis. Our study examined the expression of Slit2 and its receptor, Robo1, in a rat model of streptozotocin-induced diabetes and in patients with proliferative diabetic retinopathy. METHODS: Diabetes was induced in male Sprague-Dawley rats via a single, intraperitoneal injection of streptozotocin. The rats were sacrificed 1, 3 or 6 months after the injection. The expression of Slit2 and Robo1 in retinal tissue was measured by real-time reverse transcription polymerase chain reaction (RT-PCR), and protein levels were measured by western blotting and immunohistochemistry...
2017: PloS One
https://www.readbyqxmd.com/read/28964682/association-of-functional-snp-1562c-t-in-mmp9-promoter-with-proliferative-diabetic-retinopathy-in-north-indian-type-2-diabetes-mellitus-patients
#16
Kanhaiya Singh, Prabhjot Goyal, Manju Singh, Sujit Deshmukh, Divyesh Upadhyay, Sri Kant, Neeraj K Agrawal, Sanjeev K Gupta, Kiran Singh
OBJECTIVE: Retinal angiogenesis is a hallmark of diabetic retinopathy. Matrix Metalloproteinases (MMPs) are involved in degradation of extracellular matrix (ECM). Functional SNP-1562C>T in the promoter of the MMP-9 gene results increase in transcriptional activity. The present work was designed to evaluate the contribution of functional SNP-1562C>T of MMP-9 gene to the risk of proliferative diabetic retinopathy (PDR) in type 2 diabetes mellitus (T2DM) patients in north Indian Population...
August 26, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28947815/resveratrol-reverses-the-adverse-effects-of-bevacizumab-on-cultured-arpe-19-cells
#17
Murali Subramani, Murugeswari Ponnalagu, Lekshmi Krishna, Nallathambi Jeyabalan, Priyanka Chevour, Anupam Sharma, Chaitra Jayadev, Rohit Shetty, Nargis Begum, Govindaraju Archunan, Debashish Das
Age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR) are one of the major causes of blindness caused by neo-vascular changes in the retina. Intravitreal anti-VEGF injections are widely used in the treatment of wet-AMD and PDR. A significant percentage of treated patients have complications of repeated injections. Resveratrol (RES) is a polyphenol phytoalexin with anti-oxidative, anti-inflammatory and anti-proliferative properties. Hence, we hypothesized that if RES is used in combination with bevacizumab (BEV, anti-VEGF), it could reverse the adverse effects that precipitate fibrotic changes, drusen formation, tractional retinal detachment and so on...
September 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28937866/soluble-vascular-adhesion-protein-1-mediates-spermine-oxidation-as-semicarbazide-sensitive-amine-oxidase-possible-role-in-proliferative-diabetic-retinopathy
#18
Miyuki Murata, Kousuke Noda, Akiko Kawasaki, Shiho Yoshida, Yoko Dong, Michiyuki Saito, Zhenyu Dong, Ryo Ando, Shohei Mori, Wataru Saito, Atsuhiro Kanda, Susumu Ishida
Purpose/Aim of the study: To explore the possible role of vascular adhesion protein-1 (VAP-1) via its enzymatic function as a semicarbazide-sensitive amine oxidase (SSAO) in the pathogenesis of proliferative diabetic retinopathy (PDR). MATERIALS AND METHODS: The levels of soluble VAP-1/SSAO and the unsaturated aldehyde acrolein (ACR)-conjugated protein, N(ε)-(3-formyl-3, 4-dehydropiperidino) lysine adduct (FDP-Lys), were measured in vitreous fluid samples of PDR and non-diabetic patients using ELISA...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937857/evaluation-of-retinal-blood-flow-before-and-after-panretinal-photocoagulation-using-pattern-scan-laser-for-diabetic-retinopathy
#19
Yoshihisa Yamada, Kiyoshi Suzuma, Naoko Onizuka, Masafumi Uematsu, Yasser Helmy Mohamed, Takashi Kitaoka
PURPOSE: Laser speckle flowgraphy (LSFG) can measure blood flow in the ocular fundus. We analyzed the relationship between retinal blood flow and panretinal photocoagulation (PRP) in diabetic retinopathy. METHODS: This retrospective observational study examined the eyes of 35 patients with proliferative diabetic retinopathy (PDR) or non-PDR (NPDR). PRP was performed using a pattern scan laser. Using LSFG, blood flow was evaluated as the mean blur rate (MBR) or the relative flow volume (RFV)...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937527/relationship-between-obstructive-sleep-apnea-and-the-presence-and-severity-of-diabetic-retinopathy
#20
Aimee C Chang, Timothy P Fox, Shutao Wang, Albert Y Wu
PURPOSE: To evaluate the relationship between obstructive sleep apnea (OSA) and the presence and severity of diabetic retinopathy (DR). METHODS: Three hundred seventeen patients with International Classification of Diseases diagnoses of both DR and OSA were evaluated retrospectively. Diabetic retinopathy severity and diabetic macular edema status were determined by diagnostic coding and medical records. Obstructive sleep apnea severity and additional sleep measures were obtained from overnight polysomnography...
September 20, 2017: Retina
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