keyword
https://read.qxmd.com/read/38534040/characterization-of-the-visually-impaired-patients-with-diabetes-mellitus-in-japan
#1
JOURNAL ARTICLE
Yuka Sugihara, Yoshihiro Takamura, Yutaka Yamada, Masakazu Morioka, Makoto Gozawa, Kumiko Kato, Takao Hirano, Fumiko Murao, Miho Shimizu, Sentaro Kusuhara, Tomoya Murakami, Yuki Takenaka, Naoko Okabe, Tatsuya Jujo, Hiroto Terasaki, Daisuke Nagasato, Zhenyu Dong, Shigeo Yoshida, Shuntaro Ogura, Kanako Yasuda, Gaku Ishigooka, Osamu Sawada, Fumiaki Higashijima, Masaru Inatani
AIMS/INTRODUCTION: To conduct a multicenter survey of visually impaired patients with diabetes mellitus (DM) and to identify the physical and ocular characteristics that lead to blindness in Japan. MATERIALS AND METHODS: Visually impaired patients with diabetes mellitus in Japan were divided into blind and low-vision groups according to the World Health Organization classification. Data on parameters related to diabetes mellitus and ocular complications in the right and left eyes were collected from 19 highly advanced medical facilities and compared between the two groups...
March 27, 2024: Journal of Diabetes Investigation
https://read.qxmd.com/read/38533176/serum-and-vitreous-levels-of-placenta-growth-factor-in-diabetic-retinopathy-patients-correlation-with-disease-severity-and-optical-coherence-tomographic-parameters
#2
JOURNAL ARTICLE
Joana Mesquita, Fátima Milhano Santos, João Paulo Sousa, Sara Vaz-Pereira, Paulo Tavares-Ratado, Arminda Neves, Rita Mesquita, Cândida Teixeira Tomaz
Purpose The primary objective of this study was to compare placenta growth factor (PlGF) levels in the serum and vitreous of diabetic retinopathy (DR) patients to non-diabetic controls. Additionally, the study aimed to establish associations between serum and vitreous PlGF concentrations and to examine the correlation between vitreous PlGF in DR patients and morphological parameters. Methods This study included serum and vitreous samples from 38 patients, including 21 patients with DR and 17 non-diabetic controls...
February 2024: Curēus
https://read.qxmd.com/read/38530988/investigating-the-utility-of-near-infrared-reflectance-imaging-for-diabetic-retinopathy-screening
#3
JOURNAL ARTICLE
Sachi A Patil, Samyuktha P Guttha, Archana A Nair, Saagar Pandit, Ravi Parikh, Ting-Fang Lee, Jiyuan Hu, Nitish Mehta, Yasha S Modi
BACKGROUND AND OBJECTIVE: We investigated the reliability of near-infrared reflectance (NIR) imaging as a method of assessing severity of diabetic retinopathy (DR). PATIENTS AND METHODS: One hundred ninety-five NIR images were reviewed by two graders for the number of hyporeflective foci, presence or absence of vascular abnormalities, and presumptive DR stage; these were correlated to fundus photography-defined DR stage. Interrater reliability was confirmed via one-way random effects model of intraclass correlation coefficients...
March 1, 2024: Ophthalmic Surgery, Lasers & Imaging Retina
https://read.qxmd.com/read/38526804/diabetic-disease-of-the-eye-in-canada-consensus-statements-from-a-retina-specialist-working-group
#4
JOURNAL ARTICLE
Amer Omar, R Geoff Williams, James Whelan, Jason Noble, Michael H Brent, Michel Giunta, Sébastien Olivier, Mustapha Lhor
Despite advances in systemic care, diabetic disease of the eye (DDE) remains the leading cause of blindness worldwide. There is a critical gap of up-to-date, evidence-based guidance for ophthalmologists in Canada that includes evidence from recent randomized controlled trials. Previous guidance has not always given special consideration to applying treatments and managing DDE in the context of the healthcare system. This consensus statement aims to assist practitioners in the field by providing a spectrum of acceptable opinions on DDE treatment and management from recognized experts in the field...
March 23, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38524349/progression-of-diabetic-retinopathy-following-uncomplicated-phacoemulsification-a-prospective-study-from-south-india
#5
JOURNAL ARTICLE
R Sruthi, Seshadri J Saikumar, Mahesh Gopalakrishnan
AIM: The aim of this study was to study the progression of diabetic retinopathy (DR) and macular edema in uncomplicated phacoemulsification in patients with diabetes mellitus with a follow-up of 6 months. METHODS: A prospective, nonrandomized study was conducted on patients with established or no DR in a known case of diabetes mellitus undergoing cataract surgery by phacoemulsification, with no intraoperative complications. Detailed ophthalmic evaluation including fundus examination was done in all cases, and DR staging was done...
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38524319/phacoemulsification-in-patients-with-diabetic-macular-edema-a-real-world-data-of-75-eyes
#6
JOURNAL ARTICLE
Shikha Talwar Bassi, Shebin Salim, Ekta Rishi
PURPOSE: The purpose of this study was to evaluate the outcomes of phacoemulsification with intravitreal triamcinolone acetonide (IVTA) injection in patients with cataract and diabetic macular edema (DME) across the grades of diabetic retinopathy (DR). MATERIALS AND METHODS: It was a retrospective observational study. The study included 70 patients (75 eyes) with cataract and clinically significant macular edema in diabetics with nonproliferative (61 eyes) or proliferative (14 eyes) DR who underwent phacoemulsification with IVTA...
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38523129/the-incidence-and-prevalence-of-diabetic-macular-edema-and-proliferative-diabetic-retinopathy-their-progression-to-visual-impairment-and-patterns-in-their-intravitreal-treatment-in-the-finnish-population
#7
JOURNAL ARTICLE
Hanna Heloterä, Martti Arffman, Reijo Sund, Ilmo Keskimäki, Kai Kaarniranta
PURPOSE: The worldwide prevalence of diabetes mellitus (DM) continues to increase. As DM is linked to various ophthalmological comorbidities, it is crucial to understand the incidence and the treatment patterns of these complications to minimise the treatment burden for the patient and the healthcare system. This study aims to evaluate the incidence and prevalence of diabetic macular oedema (DME) and proliferative diabetic retinopathy (PDR) and to analyse intravitreal (IVT) treatment patterns and responses in the Finnish population with diabetes...
March 24, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38521836/associations-between-lipid-abnormalities-and-diabetic-retinopathy-across-a-large-united-states-national-database
#8
JOURNAL ARTICLE
Hejin Jeong, Christopher M Maatouk, Matthew W Russell, Rishi P Singh
BACKGROUND/OBJECTIVES: While dyslipidaemia has been suggested as a potential risk factor for diabetic retinopathy (DR), previous studies have reported conflicting findings. This study aimed to better characterize the relationship between abnormal serum levels of various lipid markers and the risk of the development and progression of DR. SUBJECTS/METHODS: This retrospective cohort study utilized a United States national database of electronic medical records. Adults with a history of type 2 diabetes mellitus without type 1 diabetes mellitus were divided into cohorts based on the presence of abnormal serum levels of various lipid markers...
March 23, 2024: Eye
https://read.qxmd.com/read/38521424/optical-coherence-tomography-angiography-in-diabetic-retinopathy-a-major-review
#9
REVIEW
Hosein Nouri, Seyed-Hossein Abtahi, Mehdi Mazloumi, Sanam Samadikhadem, J Fernando Arevalo, Hamid Ahmadieh
Diabetic retinopathy (DR) is characterized by retinal vasculopathy and is a leading cause of visual impairment. Optical coherence tomography angiography (OCTA) is an innovative imaging technology that can detect various pathologies and quantifiable changes in retinal microvasculature. We briefly describe its functional principles and advantages over fluorescein angiography and perform a comprehensive review on its clinical applications in the screening or management of people with prediabetes, diabetes without clinical retinopathy (NDR), nonproliferative DR (NPDR), proliferative DR (PDR), and diabetic macular edema (DME)...
March 21, 2024: Survey of Ophthalmology
https://read.qxmd.com/read/38517436/enrollment-in-high-deductible-health-plans-and-incident-diabetes-complications
#10
JOURNAL ARTICLE
Rozalina G McCoy, Kavya S Swarna, David H Jiang, Holly K Van Houten, Jie Chen, Esa M Davis, Jeph Herrin
IMPORTANCE: Preventing diabetes complications requires monitoring and control of hyperglycemia and cardiovascular risk factors. Switching to high-deductible health plans (HDHPs) has been shown to hinder aspects of diabetes care; however, the association of HDHP enrollment with microvascular and macrovascular diabetes complications is unknown. OBJECTIVE: To examine the association between an employer-required switch to an HDHP and incident complications of diabetes...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38514853/retinal-vasculature-of-different-diameters-and-plexuses-exhibit-distinct-vulnerability-in-varying-severity-of-diabetic-retinopathy
#11
JOURNAL ARTICLE
Alaa E Fayed, Martin J Menten, Linus Kreitner, Johannes C Paetzold, Daniel Rueckert, Sherry M Bassily, Ramy R Fikry, Ahmed M Hagag, Sobha Sivaprasad
OBJECTIVES: To study the changes in vessel densities (VD) stratified by vessel diameter in the retinal superficial and deep vascular complexes (SVC/DVC) using optical coherence tomography angiography (OCTA) images obtained from people with diabetes and age-matched healthy controls. METHODS: We quantified the VD based on vessel diameter categorized as <10, 10-20 and >20 μm in the SVC/DVC obtained on 3 × 3 mm2 OCTA scans using a deep learning-based segmentation and vascular graph extraction tool in people with diabetes and age-matched healthy controls...
March 21, 2024: Eye
https://read.qxmd.com/read/38510674/chronic-ocular-small-vessel-disease-an-overview-of-diabetic-retinopathy-and-its-relationship-with-cardiovascular-health
#12
JOURNAL ARTICLE
Siva S R Iyer, Nila S Radhakrishnan, Ramak Roohipourmoallai, Cynthia M Guerin, Jeremy S Maylath, Nickolas Garson
Diabetic retinopathy (DR) is a potentially blinding disease originating from small vessel damage in the retina in chronic hyperglycemic states. DR has a complex multi-pathway driven pathogenesis resulting in diabetic macular edema and retinal ischemia, the former being the most common cause of vision impairment in DR. Hypoxia induced cytokines stimulate vascular endothelial growth factor (VEGF) production and subsequent angiogenesis with resultant mechanical retinal damage over time. Anti-VEGF therapy is effective for the treatment of center-involving diabetic macular edema...
May 2023: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38509341/effectiveness-and-safety-of-empagliflozin-final-results-from-the-emprise-study
#13
JOURNAL ARTICLE
Phyo T Htoo, Helen Tesfaye, Sebastian Schneeweiss, Deborah J Wexler, Brendan M Everett, Robert J Glynn, Niklas Schmedt, Lisette Koeneman, Anouk Déruaz-Luyet, Julie M Paik, Elisabetta Patorno
AIMS/HYPOTHESIS: Limited evidence exists on the comparative safety and effectiveness of empagliflozin against alternative glucose-lowering medications in individuals with type 2 diabetes with the broad spectrum of cardiovascular risk. The EMPagliflozin compaRative effectIveness and SafEty (EMPRISE) cohort study was designed to monitor the safety and effectiveness of empagliflozin periodically for a period of 5 years with data collection from electronic healthcare databases. METHODS: We identified individuals ≥18 years old with type 2 diabetes who initiated empagliflozin or dipeptidyl peptidase-4 inhibitors (DPP-4i) from 2014 to 2019 using US Medicare and commercial claims databases...
March 21, 2024: Diabetologia
https://read.qxmd.com/read/38509306/rna-binding-proteins-potentially-regulate-the-alternative-splicing-of-cell-cycle-associated-genes-in-proliferative-diabetic-retinopathy
#14
JOURNAL ARTICLE
Ning Yang, Ningzhi Zhang, Guojing Lu, Siyu Zeng, Yiqiao Xing, Lei Du
RNA-binding proteins (RBPs) contribute to the pathogenesis of proliferative diabetic retinopathy (PDR) by regulating gene expression through alternative splicing events (ASEs). However, the RBPs differentially expressed in PDR and the underlying mechanisms remain unclear. Thus, this study aimed to identify the differentially expressed genes in the neovascular membranes (NVM) and retinas of patients with PDR. The public transcriptome dataset GSE102485 was downloaded from the Gene Expression Omnibus database, and samples of PDR and normal retinas were analyzed...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38496786/doppler-ultrasound-based-evaluation-of-hemodynamic-changes-in-the-ophthalmic-artery-and-central-retinal-artery-in-patients-with-type-1-diabetes-mellitus-without-retinopathy-and-with-mild-non-proliferative-retinopathy
#15
JOURNAL ARTICLE
Magdalena Pauk-Domańska, Agnieszka Wilczewska, Dominika Jaguś, Bartosz Kaczyński, Wiesław Jakubowski
AIM: Determination of blood flow parameters in the ophthalmic artery and central retinal artery using Doppler ultrasound in patients with type 1 diabetes mellitus without fundus signs of diabetic retinopathy and with mild non-proliferative retinopathy. MATERIAL AND METHODS: To eliminate the impact of other systemic factors on vascular flow, the study enrolled a total of 80 patients with type 1 diabetes mellitus, aged between 18 and 45 years. The study participants did not have any diabetic complications or other systemic or ocular comorbidities...
February 2024: Journal of Ultrasonography
https://read.qxmd.com/read/38496130/insights-into-visual-rehabilitation-pan-retinal-photocoagulation-for-proliferative-diabetic-retinopathy
#16
REVIEW
Meghavi Pandya, Shashank Banait, Sachin Daigavane
This review comprehensively explores pan-retinal photocoagulation (PRP) as a pivotal intervention in visually rehabilitating individuals afflicted with proliferative diabetic retinopathy (PDR). The review begins by elucidating the significance of PDR within the spectrum of diabetic retinopathy (DR), emphasizing the progressive nature of the disease and the consequential impact on visual health. A detailed analysis of PRP follows, encompassing its definition, purpose, and historical development, shedding light on the procedural intricacies and mechanisms of action...
February 2024: Curēus
https://read.qxmd.com/read/38490291/hyperglycemia-and-circadian-disruption-lead-to-retinal-dysfunction-in-a-stabilized-colony-of-the-fat-sand-rat-psammomys-obesus
#17
JOURNAL ARTICLE
Catherine E Estay-Ahumada, Daniela M Verra, Michel Roux, Fabiana Sassone, Marie-Paule Felder-Schmittbuhl, Christophe Klopp, Dominique Ciocca, Myriam Ly-Le Moal, David Hicks
PURPOSE: The Fat Sand Rat (Psammomys obesus) recapitulates several features of human pre-proliferative diabetic retinopathy, but data are restricted to wild animals, incompatible with stringent biomedical research criteria. To overcome this barrier, we characterized retinal changes in a colony of P. obsesus maintained under strictly controlled housing conditions. METHODS: Animals were maintained on low or high caloric energy diets, and raised under either standard (12 h light/12 h dark) or shortened (5 h light/5 h dark) photoperiods...
March 13, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38488432/assessing-diabetic-retinopathy-staging-with-ai-a-comparative-analysis-between-pseudocolor-and-led-imaging
#18
JOURNAL ARTICLE
Maria Vittoria Cicinelli, Salvatore Gravina, Carola Rutigliani, Lisa Checchin, Lamberto La Franca, Rosangela Lattanzio, Francesco Bandello
PURPOSE: To compare the diagnostic performance of artificial intelligence (AI)-based diabetic retinopathy (DR) staging system across pseudocolor, simulated white light (SWL), and light-emitting diode (LED) camera imaging modalities. METHODS: A cross-sectional investigation involved patients with diabetes undergoing imaging with an iCare DRSplus confocal LED camera and an Optos confocal, ultra-widefield pseudocolor camera, with and without SWL. Macula-centered and optic nerve-centered 45 × 45-degree photographs were processed using EyeArt v2...
March 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38486642/impact-of-coronavirus-disease-2019-on-intravitreal-antivascular-endothelial-growth-factor-injection-rates-in-nigerians
#19
JOURNAL ARTICLE
Ogugua Ndubuisi Okonkwo, Adekunle Olubola Hassan, Tayo Bogunjoko, Ayodele Akinye, Toyin Akanbi, Chineze Agweye
AIM: To quantify the impact of coronavirus disease 2019 (COVID-19) on the rate of intravitreal antivascular endothelial growth factor (VEGF) injections (IVI) in eye hospitals in Nigeria. MATERIALS AND METHODS: A retrospective, observational, comparative study. The IVIs given 12 months before (pre-COVID) and 12 months after the first announcement of the COVID-19 lockdown (COVID) in Nigeria in four hospitals were used as the sample for this study. All eyes were treatment naïve...
2024: Journal of the West African College of Surgeons
https://read.qxmd.com/read/38481239/extending-the-diabetic-retinopathy-screening-intervals-in-singapore-methodology-and-preliminary-findings-of-a-cohort-study
#20
JOURNAL ARTICLE
Amudha Aravindhan, Eva K Fenwick, Aurora Wing Dan Chan, Ryan Eyn Kidd Man, Ngiap Chuan Tan, Wei Teen Wong, Wern Fern Soo, Shin Wei Lim, Sabrina Yi-Mei Wee, Charumathi Sabanayagam, Eric Finkelstein, Gavin Tan, Haslina Hamzah, Bibhas Chakraborty, Sanchalika Acharyya, Tai E Shyong, Peter Scanlon, Tien Yin Wong, Ecosse L Lamoureux
BACKGROUND: The Diabetic Retinopathy Extended Screening Study (DRESS) aims to develop and validate a new DR/diabetic macular edema (DME) risk stratification model in patients with Type 2 diabetes (DM) to identify low-risk groups who can be safely assigned to biennial or triennial screening intervals. We describe the study methodology, participants' baseline characteristics, and preliminary DR progression rates at the first annual follow-up. METHODS: DRESS is a 3-year ongoing longitudinal study of patients with T2DM and no or mild non-proliferative DR (NPDR, non-referable) who underwent teleophthalmic screening under the Singapore integrated Diabetic Retinopathy Programme (SiDRP) at four SingHealth Polyclinics...
March 13, 2024: BMC Public Health
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