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Proliferative diabetic retinopathy

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https://www.readbyqxmd.com/read/28526441/conceptual-analysis-of-diabetic-retinopathy-in-ayurveda
#1
REVIEW
Prasanta Kumar Sahoo, Shamsa Fiaz
Inclusion of Prameha among the eight major disorders in Charaka Samhita shows the significance of the disease given by ancient seers. The risk of development of blindness in diabetics increases by 20-25 times as compared to the normal population. High prevalence rate of Diabetic Retinopathy (34.6%), proliferative diabetic retinopathy (7%), diabetic macular edema (6.8%), and Vision threatening Diabetic retinopathy (10.2%) in diabetics was great concerns which led to search and analyze the disease process on the basis of modern pathogenesis and different Timirvyadhi mentioned in Ayurvedic authoritative texts...
May 16, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28516404/screening-for-diabetic-eye-disease-among-samoan-adults-a-pilot-study
#2
V Swetha E Jeganathan, Tim Langford, Lucilla Ah-Ching Sefo, Alex W Hewitt, Nitin Verma
INTRODUCTION: The purpose of this study was to determine the prevalence of diabetic retinopathy in Samoa by piloting a retinal photography screening programme. METHODS: We performed a cross-sectional study of patients with diabetes who presented to the Tupua Tamasese Meaole eye clinic in Apia, Samoa, between May 2011 and September 2011. Study approval was granted by the National Health Service Board of Samoa, the Monash University Human Research Ethics Committee, and the study adhered to the Tenets of the Declaration of Helsinki...
May 17, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28512919/influence-of-serum-lipids-on-the-incidence-and-progression-of-diabetic-retinopathy-and-macular-oedema-sankara-nethralaya-diabetic-retinopathy-epidemiology-and-molecular-genetics-study-sn-dreams-ii
#3
Sangeetha Srinivasan, Rajiv Raman, Vaitheeswaran Kulothungan, Gayathri Swaminathan, Tarun Sharma
IMPORTANCE: The importance of lipids on incidence and progression of diabetic retinopathy has not been studied in the Indian population. BACKGROUND: To elucidate the influence of serum lipid control on the incidence and progression of diabetic retinopathy and diabetic macular oedema in subjects with type 2 diabetes. DESIGN: population-based longitudinal observational study in a hospital setting. PARTICIPANTS: 890 subjects were examined at baseline and follow-up METHODS: Diabetic retinopathy was graded per Modified Early Treatment Diabetic Retinopathy Study scales; 45°, 4-field dilated stereoscopic digital photography was performed with an additional 30°, 7-field for those who had retinopathy...
May 17, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28510630/local-and-systemic-inflammatory-biomarkers-of-diabetic-retinopathy-an-integrative-approach
#4
Stela Vujosevic, Rafael Simó
Purpose: To review the usefulness of local and systemic inflammatory biomarkers of diabetic retinopathy (DR) to implement a more personalized treatment. Methods: An integrated research (from ophthalmologist and diabetologist point of view) of most significant literature on serum, vitreous, and aqueous humor (AH) biochemical biomarkers related to inflammation at early and advanced stages of DR (including diabetic macular edema [DME] and proliferative DR) was performed...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28503423/microrna-126-a-promising-novel-biomarker-in-peripheral-blood-for-diabetic-retinopathy
#5
Li-Li Qin, Mei-Xia An, Yan-Li Liu, Han-Chun Xu, Zhi-Qing Lu
AIM: To investigate the content of serum microRNA-126 (miR-126) and its role in screening retinal endothelial injury and early diagnosis of proliferative diabetic retinopathy. METHODS: The study included 184 serum samples, 59 samples from healthy individuals, 44 samples from diabetes mellitus (DM) patients without diabetic retinopathy (NDR), 42 from non-proliferative diabetic retinopathy (NPDR) patients and 39 samples from proliferative diabetic retinopathy (PDR) patients...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28499048/three-different-optical-coherence-tomography-angiography-measurement-methods-for-assessing-capillary-density-changes-in-diabetic-retinopathy
#6
Alexandre Pedinielli, Sophie Bonnin, Mohamed El Sanharawi, Valérie Mané, Ali Erginay, Aude Couturier, Ramin Tadayoni
BACKGROUND AND OBJECTIVE: To compare capillary density (CD) changes assessed by optical coherence tomography angiography (OCTA) during diabetic retinopathy (DR) progression using three previously published methods: binarization, skeletonization, and automated flow density (AFD). PATIENTS AND METHODS: Retrospective study of 98 eyes of 74 patients with diabetes and 18 control eyes imaged using OCTA. The macular CD at each stage of DR was assessed using the three methods and were compared to control eyes...
May 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28498374/ranibizumab-pretreatment-in-diabetic-vitrectomy-a-pilot-randomised-controlled-trial-the-radivit-study
#7
O Comyn, L Wickham, D G Charteris, P M Sullivan, E Ezra, Z Gregor, G W Aylward, L da Cruz, D Fabinyi, T Peto, M Restori, W Xing, C Bunce, P G Hykin, J W Bainbridge
PurposeOur aim was to evaluate the impact of intravitreal ranibizumab pretreatment on the outcome of vitrectomy surgery for advanced proliferative diabetic retinopathy. The objective was to determine the feasibility of a subsequent definitive trial and estimate the effect size and variability of the outcome measure.Patients and methodsWe performed a pilot randomised double-masked single-centre clinical trial in 30 participants with tractional retinal detachment associated with proliferative diabetic retinopathy...
May 12, 2017: Eye
https://www.readbyqxmd.com/read/28497987/elevated-activating-transcription-factor-4-and-glucose-regulated-78-kda-protein-levels-correlate-with-inflammatory-cytokines-in-the-aqueous-humor-and-vitreous-of-proliferative-diabetic-retinopathy
#8
Yanuo Wang, Sha Gao, Yanji Zhu, Xi Shen
PURPOSE: To determine concentrations of endoplasmic reticulum (ER) stress-related factors activating transcription factor 4 (ATF4) and glucose-regulated 78 kDa protein (GRP78) in vitreous and aqueous humor (AqH) of patients with proliferative diabetic retinopathy (PDR) and the correlation of ATF4, GRP78 and inflammatory cytokines interleukin-6(IL-6) and monocyte chemoattractant protein-1 (MCP-1). MATERIALS AND METHODS: AqH and vitreous samples were collected from eyes of patients with PDR and idiopathic macular hole (IMH) which needed vitrectomy...
May 12, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28495904/assessing-total-retinal-blood-flow-in-diabetic-retinopathy-using-multiplane-en-face-doppler-optical-coherence-tomography
#9
Alex D Pechauer, Thomas S Hwang, Ahmed M Hagag, Liang Liu, Ou Tan, Xinbo Zhang, Maria Parker, David Huang, David J Wilson, Yali Jia
AIM: To assess total retinal blood flow (TRBF) in diabetic retinopathy (DR) using multiplane en face Doppler optical coherence tomography (OCT). METHODS: A 70 kHz spectral-domain OCT system scanned a 2×2 mm area centred at the optic disc of the eyes with DR and healthy participants. The multiplane en face Doppler OCT algorithm generated a three-dimensional volumetric data set consisting of 195 en face planes. The TRBF was calculated from the maximum flow values of each branching retinal vein at an optimised en face plane...
May 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28494921/proliferative-diabetic-retinopathy-laser-or-eye-injection
#10
Daniel Shu Wei Ting, Tien Yin Wong
No abstract text is available yet for this article.
May 5, 2017: Lancet
https://www.readbyqxmd.com/read/28494920/clinical-efficacy-of-intravitreal-aflibercept-versus-panretinal-photocoagulation-for-best-corrected-visual-acuity-in-patients-with-proliferative-diabetic-retinopathy-at-52-weeks-clarity-a-multicentre-single-blinded-randomised-controlled-phase-2b-non-inferiority
#11
Sobha Sivaprasad, A Toby Prevost, Joana C Vasconcelos, Amy Riddell, Caroline Murphy, Joanna Kelly, James Bainbridge, Rhiannon Tudor-Edwards, David Hopkins, Philip Hykin
BACKGROUND: Proliferative diabetic retinopathy is the most common cause of severe sight impairment in people with diabetes. Proliferative diabetic retinopathy has been managed by panretinal laser photocoagulation (PRP) for the past 40 years. We report the 1 year safety and efficacy of intravitreal aflibercept. METHODS: In this phase 2b, single-blind, non-inferiority trial (CLARITY), adults (aged ≥18 years) with type 1 or 2 diabetes and previously untreated or post-laser treated active proliferative diabetic retinopathy were recruited from 22 UK ophthalmic centres...
May 5, 2017: Lancet
https://www.readbyqxmd.com/read/28492921/interim-safety-data-comparing-ranibizumab-with-panretinal-photocoagulation-among-participants-with-proliferative-diabetic-retinopathy
#12
Jeffrey G Gross, Adam R Glassman, Margaret J Klein, Lee M Jampol, Frederick L Ferris, Neil M Bressler, Roy W Beck
No abstract text is available yet for this article.
May 8, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28492920/cost-effectiveness-of-intravitreous-ranibizumab-compared-with-panretinal-photocoagulation-for-proliferative-diabetic-retinopathy-secondary-analysis-from-a-diabetic-retinopathy-clinical-research-network-randomized-clinical-trial
#13
David W Hutton, Joshua D Stein, Neil M Bressler, Lee M Jampol, David Browning, Adam R Glassman
Importance: The Diabetic Retinopathy Clinical Research Network Protocol S randomized clinical trial results suggest that ranibizumab is a reasonable treatment alternative to panretinal photocoagulation (PRP) when managing proliferative diabetic retinopathy (PDR), with or without concomitant baseline diabetic macular edema (DME). However, ranibizumab injections are costly. Thus, it would be useful to examine the relative cost-effectiveness of these 2 treatment modalities. Objective: To evaluate incremental cost-effectiveness ratios of 0...
May 8, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28492855/incremental-cost-effectiveness-of-proliferative-diabetic-retinopathy-treatments-the-certainty-of-uncertainty
#14
Steven M Kymes
No abstract text is available yet for this article.
May 8, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28491870/noninvasive-retinal-markers-in-diabetic-retinopathy-advancing-from-bench-towards-bedside
#15
REVIEW
Søren Leer Blindbæk, Thomas Lee Torp, Kristian Lundberg, Kerstin Soelberg, Anna Stage Vergmann, Christina Døfler Poulsen, Ulrik Frydkjaer-Olsen, Rebecca Broe, Malin Lundberg Rasmussen, Jimmi Wied, Majbrit Lind, Anders Højslet Vestergaard, Tunde Peto, Jakob Grauslund
The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- and macrovascular dysfunction in diabetes. Likewise, the retinal metabolism can be evaluated by retinal oximetry, and higher retinal venular oxygen saturation has been demonstrated in patients with diabetic retinopathy...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28489694/efficacy-of-intravitreal-ranibizumab-injections-in-the-treatment-of-vitreous-hemorrhage-related-to-proliferative-diabetic-retinopathy
#16
Elias Chelala, Joseph Nehme, Hala El Rami, Roni Aoun, Ali Dirani, Ali Fadlallah, Alex Jalkh
PURPOSE: To investigate the efficacy of intravitreal ranibizumab injections in proliferative diabetic retinopathy associated with vitreous hemorrhage (VH). METHODS: A prospective study including patients with proliferative diabetic retinopathy who presented with persistent VH. Vitreous hemorrhage was graded into mild, moderate, and severe. Patients were randomized into two groups: the ranibizumab group was treated with intravitreal injections of ranibizumab and the control group was assigned to observation alone...
May 9, 2017: Retina
https://www.readbyqxmd.com/read/28487377/the-uk-diabetic-retinopathy-electronic-medical-record-uk-dr-emr-users-group-report-2-real-world-data-for-the-impact-of-cataract-surgery-on-diabetic-macular-oedema
#17
Alastair K Denniston, Usha Chakravarthy, Haogang Zhu, Aaron Y Lee, David P Crabb, Adnan Tufail, Clare Bailey, Toks Akerele, Sahar Al-Husainy, Christopher Brand, Louise Downey, Alan Fitt, Rehna Khan, Vineeth Kumar, Aires Lobo, Sajjad Mahmood, Kaveri Mandal, Martin Mckibbin, Geeta Menon, Salim Natha, Jong Min Ong, Marie D Tsaloumas, Atul Varma, Elizabeth Wilkinson, Robert L Johnston, Catherine A Egan
AIM: To assess the rate of 'treatment-requiring diabetic macular oedema (DMO)' in eyes for the two  years before and after cataract surgery. METHODS: Multicentre national diabetic retinopathy (DR) database study with anonymised data extraction across 19 centres from an electronic medical record system. INCLUSION CRITERIA: eyes undergoing cataract surgery in patients with diabetes with no history of DMO prior to study start. The minimum dataset included: age, visual acuity (all time-points), injection episodes, timing of cataract surgery and ETDRS grading of retinopathy and maculopathy...
May 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28484955/ranibizumab-in-the-treatment-of-diabetic-macular-edema-a-review-of-the-current-status-unmet-needs-and-emerging-challenges
#18
REVIEW
Nikolaos Dervenis, Athanasia Maria Mikropoulou, Paris Tranos, Panagiotis Dervenis
Diabetic retinopathy (more specifically diabetic macular edema, DME) is the most common cause of loss of vision in the working population in developed countries. Anti-vascular endothelial growth factor (anti-VEGF) agents considerably changed the treatment algorithms and improved prognosis of center-involving DME. Ranibizumab was the first approved anti-VEGF agent that revolutionized DME treatment. The vast increase in the number of patients undergoing intravitreal treatment and the role of anti-VEGF pharmacotherapy as the mainstay of DME treatment have triggered several challenges...
May 8, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28484225/multimodality-analysis-of-hyper-reflective-foci-and-hard-exudates-in-patients-with-diabetic-retinopathy
#19
Sijie Niu, Chenchen Yu, Qiang Chen, Songtao Yuan, Jiang Lin, Wen Fan, Qinghuai Liu
To investigate the correlations between hyper-reflective foci and hard exudates in patients with non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) by spectral-domain optical coherence tomography (SD OCT) images. Hyper-reflective foci in retinal SD OCT images were automatically detected by the developed algorithm. Then, the cropped CFP images generated by the semi-automatic registration method were automatically segmented for the hard exudates and corrected by the experienced clinical ophthalmologist...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28483496/relationship-between-internal-reflectivity-of-diabetic-microaneurysms-on-sd-oct-and-detection-on-oct-angiography
#20
Mariacristina Parravano, Daniele De Geronimo, Fabio Scarinci, Lea Querques, Gianni Virgili, Joseph Michael Simonett, Monica Varano, Francesco Bandello, Giuseppe Querques
PURPOSE: To correlate the appearance of Microaneurysms (MAs) on structural spectral-domain optical coherence tomography (SD-OCT) with their detection on OCT angiography (OCTA) in patients with non-proliferative diabetic retinopathy (NPDR). DESIGN: Inter-instrument reliability study. METHODS: Sixteen patients with NPDR without macular edema underwent SD-OCT and OCTA. To compare MAs seen on OCTA to those on SD-OCT, we superimposed the OCTA superficial capillary plexus (SCP) vascular landmarks onto those of the near infrared...
May 5, 2017: American Journal of Ophthalmology
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