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Proliferative diabetic retinopathy

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https://www.readbyqxmd.com/read/28318640/the-prevalence-of-diabetic-retinopathy-in-australian-adults-with-self-reported-diabetes-the-national-eye-health-survey
#1
Stuart Keel, Jing Xie, Joshua Foreman, Peter van Wijngaarden, Hugh R Taylor, Mohamed Dirani
PURPOSE: To determine the prevalence of and factors associated with diabetic retinopathy (DR) among non-Indigenous and Indigenous Australian adults with self-reported diabetes. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Non-Indigenous Australians (50-98 years of age) and Indigenous Australians (40-92 years of age) with known diabetes. METHODS: Diabetes was determined based on self-report of previous diagnosis of the disease...
March 15, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28299499/evaluation-of-vitreous-levels-of-advanced-glycation-end-products-and-angiogenic-factors-as-biomarkers-for-severity-of-diabetic-retinopathy
#2
Makiko Katagiri, Jun Shoji, Noriko Inada, Satoshi Kato, Shigehiko Kitano, Yasuko Uchigata
BACKGROUND/AIMS: Glyceraldehyde-derived advanced glycation end products (glycer-AGE; also called Toxic-AGE [TAGE]) play a crucial role in the pathogenesis of diabetic angiopathy. However, the relationships between vitreous glycer-AGE levels and diabetic retinopathy (DR) severity, and between glycer-AGE levels and the levels of other angiogenic factors remain unknown. We investigated the correlation between levels of vitreous biomarkers, including glycer-AGE and angiogenic factors (vascular endothelial growth factor [VEGF], interleukin [IL]-8, leptin, placental growth factor [PlGF], endoglin, and fibroblast growth factor [FGF]-2) in patients with DR, using three DR staging groups...
March 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28287861/association-of-skin-intrinsic-fluorescence-with-retinal-microvascular-complications-of-long-term-type-1-diabetes-in-the-wisconsin-epidemiologic-study-of-diabetic-retinopathy
#3
Barbara E K Klein, Kayla L Horak, John D Maynard, Kristine E Lee, Ronald Klein
OBJECTIVE: To determine the association between skin intrinsic fluorescence (SIF), a noninvasive measure of advanced glycation endproducts and oxidative stress in skin, and retinal microvascular complications of long duration type 1 diabetes, proliferative diabetic retinopathy (PDR) and macular edema. METHODS: A cross-sectional cohort study of persons with type 1 diabetes in the Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR) who participated in a 32-year follow-up examination in 2012-2014...
March 13, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28282610/retinal-pigment-epithelium-secretome-a-diabetic-retinopathy-perspective
#4
REVIEW
Murugeswari Ponnalagu, Murali Subramani, Chaitra Jayadev, Rohit Shetty, Debashish Das
Diabetic retinopathy is a major complication of diabetes mellitus that can lead to retinal vascular abnormalities and visual impairment. While retinal endothelial pathology is well studied, retinal pigment epithelium (RPE) layer modifications and the patho-physiological regulations are not widely understood. The RPE is a highly specialized pigmented layer regulating not only physiological functions such as transport of nutrients, ions, absorption of light, phagocytosis of photoreceptor membranes, but also secretion of a number of cytokines, chemokines, angiogenic and anti-angiogenic factors...
March 7, 2017: Cytokine
https://www.readbyqxmd.com/read/28280298/corneal-endothelium-and-central-corneal-thickness-changes-in-type-2-diabetes-mellitus
#5
Amira El-Agamy, Shams Alsubaie
PURPOSE: This study was conducted to compare the corneal endothelial cell density (ECD), morphological features, and central corneal thickness (CCT) in type 2 diabetes mellitus (DM) with age-matched, nondiabetic control subjects using EM-3000 Specular Microscope. STUDY DESIGN: This was a prospective, hospital-based, nonrandomized, case-control, observational, and quantitative study. SUBJECTS AND METHODS: The study included 57 patients (57 eyes) with type 2 DM and 45 control (nondiabetic) subjects (45 eyes)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28279572/association-of-serum-levels-of-anti-myeloperoxidase-antibody-with-retinal-photoreceptor-ellipsoid-zone-disruption-in-diabetic-retinopathy
#6
Shivani Sinha, Sandeep Saxena, Senthamizh Prasad, Abbas Ali Mahdi, Shashi Kumar Bhasker, Siddharth Das, Vladimir Krasnik, Martin Caprnda, Radka Opatrilova, Peter Kruzliak
AIM: To study the association of serum levels of anti-myeloperoxidase (MPO) antibody with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy. METHODS: Consecutive patients with type 2 DM [diabetes mellitus with no retinopathy (NODR; n=20); non-proliferative diabetic retinopathy (NPDR; n=18); proliferative diabetic retinopathy (PDR; n=16)] and healthy controls (n=20) between the ages of 40 and 65years were included. Disruption of EZ was graded by spectral domain optical coherence tomography as no disruption of EZ and disrupted EZ...
February 28, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28277285/bevacizumab-and-panretinal-photocoagulation-protect-against-ocular-hypertension-after-posterior-subtenon-injection-of-triamcinolone-acetonide-for-diabetic-macular-edema
#7
Yi-Ting Hsieh, Chung-May Yang, Shu-Hui Chang
BACKGROUND/PURPOSE: To analyze the prognostic factors for ocular hypertension after posterior subtenon injection of triamcinolone acetonide (PSTA) for the treatment of diabetic macular edema (DME). METHODS: Patients who received PSTA for DME from January 2006 to December 2011 were enrolled retrospectively and were followed until December 2012 in one hospital. Modified Cox regression models were used to analyze the factors associated with ocular hypertension, which was defined as an intraocular pressure>21 mmHg after PSTA...
October 27, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28273240/the-effect-of-laser-pan-retinal-photocoagulation-with-or-without-intravitreal-bevacizumab-injections-on-the-oct-measured-macular-choroidal-thickness-of-eyes-with-proliferative-diabetic-retinopathy
#8
Rony C Preti, Anibal Mutti, Daniel A Ferraz, Leandro C Zacharias, Yoshitaka Nakashima, Walter Y Takahashi, Mario L R Monteiro
OBJECTIVES: To investigate the effect of laser pan-retinal photocoagulation with or without intravitreal bevacizumab injections on macular choroidal thickness parameters in eyes with high-risk proliferative diabetic retinopathy. METHODS: High-risk proliferative diabetic retinopathy patients undergoing laser treatment were prospectively enrolled in this study. One eye was randomly selected for laser treatment combined with bevacizumab injections, study group, whereas the corresponding eye was subjected to laser treatment alone, control group...
February 1, 2017: Clinics
https://www.readbyqxmd.com/read/28272719/vitreous-and-plasma-changes-of-endothelin-1-adrenomedullin-and-vascular-endothelium-growth-factor-in-patients-with-proliferative-diabetic-retinopathy
#9
E M Vingolo, S Fragiotta, M Mafrici, A Cutini, C Marinelli, A Concistrè, G Iannucci, L Petramala, C Letizia
OBJECTIVE: To assess vitreous and plasma changes of vascular endothelial growth factor A (VEGF-A), adrenomedullin (ADM) and endothelin-1 (ET-1) in proliferative diabetic retinopathy (PDR). PATIENTS AND METHODS: 9 patients with PDR in type 2 diabetes (T2DM) and 11 age-matched non-diabetic patients were enrolled. The levels of VEGF-A, ADM and ET-1 were measured using an enzyme (ELISA) and a radioimmunoassay (RIA) both in vitreous and plasma samples. RESULTS: Vitreous ADM and VEGF-A levels were significantly higher in PDR patients (p=0...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28272234/neovascular-glaucoma-after-vitrectomy-in-patients-with-proliferative-diabetic-retinopathy
#10
Jin-Woo Kwon, Donghyun Jee, Tae Yoon La
To evaluate the prevalence and risk factors of neovascular glaucoma (NVG) after vitrectomy in patients with vitreous hemorrhage associated with proliferative diabetic retinopathy (PDR). This retrospective, noncomparative, observational study included 127 eyes of 127 patients with PDR who received vitrectomy with a follow-up period of at least 6 months. The prevalence of NVG and associated risk factors were assessed including sex, age, previous panretinal photocoagulation, baseline intraocular pressure, combined phacovitrectomy, and pretreatment with intravitreal bevacizumab (IVB) before vitrectomy for the treatment of vitreous hemorrhage...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28271611/nlrp3-inflammasome-activation-is-associated-with-proliferative-diabetic-retinopathy
#11
Sirpa Loukovaara, Niina Piippo, Kati Kinnunen, Maria Hytti, Kai Kaarniranta, Anu Kauppinen
PURPOSE: Innate immunity and dysregulation of inflammatory processes play a role in vascular diseases like atherosclerosis or diabetes. Nucleotide-binding domain and Leucine-rich repeat Receptor containing a Pyrin domain 3 (NLRP3) inflammasomes are pro-inflammatory signalling complexes that were found in 2002. In addition to pathogens and other extracellular threats, they can be activated by various endogenous danger signals. The purpose of this study was to find out whether NLRP3 activation occurs in patients with sight-threatening forms of diabetic retinopathy (DR)...
March 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28271229/characteristics-of-patients-with-spontaneous-dislocation-of-in-the-bag-intraocular-lens-after-pars-plana-vitrectomy
#12
Takayuki Koike, Takayuki Baba, Tomohiro Nizawa, Toshiyuki Oshitari, Shuichi Yamamoto
PURPOSE: To determine the characteristics of eyes with late in-the-bag dislocation of an intraocular lens (IOL) after pars plana vitrectomy (PPV). METHODS: Fourteen eyes of 14 patients with a dislocated IOL after PPV were studied retrospectively. The data collected from the medical charts included the age, sex, history of eye diseases, axial length, and interval from PPV to time of IOL dislocation. The surgical procedures used during the PPV were also recorded. RESULTS: Seven eyes had undergone PPV for rhegmatogenous retinal detachment; 6 eyes, for proliferative diabetic retinopathy; and 1 eye, for retinal vein occlusion...
March 7, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28268569/automatic-detection-of-neovascularization-on-optic-disk-region-with-feature-extraction-and-support-vector-machine
#13
Shuang Yu, Di Xiao, Yogesan Kanagasingam
Neovascularization (NV) is a definitive indicator for the onset of Proliferative Diabetic Retinopathy (PDR). The new vessels are fragile and prone to bleed, leading to high risk of sudden vision loss. Automatic detection of NV is an important task in automatic Diabetic Retinopathy (DR) screening as a consequence of the unmet requirement between the growing number of DR patients and limited number of ophthalmologists. This paper focuses on the computer aided detection of neovascularization in the optic disk region...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268564/automated-detection-of-neovascularization-for-proliferative-diabetic-retinopathy-screening
#14
Sohini Roychowdhury, Dara D Koozekanani, Keshab K Parhi
Neovascularization is the primary manifestation of proliferative diabetic retinopathy (PDR) that can lead to acquired blindness. This paper presents a novel method that classifies neovascularizations in the 1-optic disc (OD) diameter region (NVD) and elsewhere (NVE) separately to achieve low false positive rates of neovascularization classification. First, the OD region and blood vessels are extracted. Next, the major blood vessel segments in the 1-OD diameter region are classified for NVD, and minor blood vessel segments elsewhere are classified for NVE...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28264049/vitreous-advanced-glycation-endproducts-and-%C3%AE-dicarbonyls-in-retinal-detachment-patients-with-type-2-diabetes-mellitus-and-non-diabetic-controls
#15
Bernardina T Fokkens, Douwe J Mulder, Casper G Schalkwijk, Jean L Scheijen, Andries J Smit, Leonoor I Los
PURPOSE: Advanced glycation endproducts (AGEs) and their precursors α-dicarbonyls are implicated in the progression of diabetic retinopathy. The purpose of this study was to assess AGEs and α-dicarbonyls in the vitreous of patients with type 2 diabetes mellitus (T2DM) with early stages or absence of diabetic retinopathy. METHODS: We examined vitreous samples obtained during vitrectomy from 31 T2DM patients presenting themselves with rhegmatogenous retinal detachment and compared these to 62 non-diabetic rhegmatogenous retinal detachment patients, matched on age, estimated glomerular filtration rate, smoking, intra-ocular lens implantation, and proliferative vitreoretinopathy...
2017: PloS One
https://www.readbyqxmd.com/read/28257831/silencing-of-galectin-1-inhibits-retinal-neovascularization-and-ameliorates-retinal-hypoxia-in-a-murine-model-of-oxygen-induced-ischemic-retinopathy
#16
Ning Yang, Wenxi Zhang, Tao He, Yiqiao Xing
Aberrant neovascularization is a consequence of inappropriate angiogenic signaling and contributes to several diseases. Although many regulators of pathogenic angiogenesis have been identified, the understanding of this process remains incomplete. Galectin-1 (Gal-1), as a homodimeric protein with a single carbohydrate-recognition domain, is implicated in several pathologic processes, including angiogenesis; however, its involvement in retinal neovascularization (RNV) remains unknown. Here, we investigated the anti-angiogenic effect of silencing Gal-1 through intravitreal injection in a mouse model of oxygen-induced retinopathy (OIR)...
February 28, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28254450/diabetic-phenotype-of-transgenic-pigs-introduced-by-dominant-negative-mutant-hepatocyte-nuclear-factor-1%C3%AE
#17
Kazuhiro Umeyama, Masami Nakajima, Takashi Yokoo, Masaki Nagaya, Hiroshi Nagashima
AIM: The present study aimed to identify the characteristics of genetically modified pigs carrying a mutant human gene as a research model for diabetes and its complications. METHODS: We developed a transgenic cloned pig (founder, male) carrying a mutant gene, i.e., human HNF-1α (P291fsinsC), which is responsible for maturity-onset diabetes of the young type 3. Transgenic progeny obtained via the artificial insemination of wild type (WT) sows with the cryopreserved sperm derived from the founder pig was pathologically examined...
February 13, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28252875/effect-of-preoperative-topical-diclofenac-on-intraocular-interleukin-12-concentration-and-macular-edema-after-cataract-surgery-in-patients-with-diabetic-retinopathy-a-randomized-controlled-trial
#18
Aleksej Medić, Tomislav Jukić, Anita Matas, Katarina Vukojević, Ada Sapunar, Ljubo Znaor
AIM: To determine if preoperative treatment with a topical non-steroidal anti-inflammatory drug (NSAID) lowers the concentration of intraocular interleukin (IL)-12 and the incidence of postoperative macular edema in patients with non-proliferative diabetic retinopathy undergoing cataract surgery. METHODS: A total of 55 patients were randomized to diclofenac (n=27) or placebo (n=28). Patients receiving diclofenac started preoperative treatment with 0.1% topical diclofenac four times a day 7 days before cataract surgery and the therapy was discontinued 30 days after surgery...
February 28, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28247336/the-role-of-dyslipidemia-control-in-the-progression-of-diabetic-retinopathy-in-patients-with-type-2-diabetes-mellitus
#19
Irini P Chatziralli
Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM) and is considered as the leading cause of visual impairment in working-aged adults worldwide. Dyslipidemia has been associated with DR, but not with progression to the proliferative form of DR, although the exact role in the pathogenesis of DR and diabetic macular edema (DME) remains controversial. As a result, a reasonable question arising is whether control of dyslipidemia may alter the course of DR. Statins do not appear to have an impact on DR progression...
February 28, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28245487/mitochondrial-haplogroups-affect-severity-but-not-prevalence-of-diabetic-retinopathy
#20
Jana A Bregman, David J Herren, Christopher B Estopinal, Isaac M Chocron, Paula A Harlow, Cassandra Warden, Milam A Brantley, David C Samuels
Purpose: We previously reported European mitochondrial haplogroup H to be a risk factor for and haplogroup UK to be protective against proliferative diabetic retinopathy (PDR) among Caucasian patients with diabetic retinopathy (DR). The purpose of this study was to determine whether these haplogroups are also associated with the risk of having DR among Caucasian patients with diabetes. Methods: Deidentified medical records for 637 Caucasian patients with diabetes (223 with DR) were obtained from BioVU, Vanderbilt University's electronic, deidentified DNA databank...
February 1, 2017: Investigative Ophthalmology & Visual Science
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