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Proliferative diabetic retinopathy

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https://www.readbyqxmd.com/read/29644239/the-correlation-between-changes-in-biochemical-parameters-and-central-macular-thickness-in-patients-with-non-proliferative-diabetic-retinopathy
#1
Ayse Gul Kocak Altintas, Bayram Gulpamuk, Veysel Cankurtaran, Cagri Ilhan, Mehmet Citirik
This study aimed at evaluating the correlation between changes in Hemoglobin A1c (HbA1c) and fasting serum lipids, and Central Macular Thickness (CMT) in patients with Non-Proliferative Diabetic Retinopathy (NPDR). In the current research, both eyes of 68 patients with mild or moderate NPDR, without clinically significant macular edema, were studied. Levels of fasting serum lipids, HbAlc, and CMT were measured during the first visit and at the end of the follow-up period (3 months). For statistical analysis, CMTs of each eye were studied and the correlation of changes was investigated...
2018: Medical Hypothesis, Discovery and Innovation in Ophthalmology
https://www.readbyqxmd.com/read/29643787/optical-coherence-tomography-angiography-of-foveal-neovascularization-in-diabetic-retinopathy
#2
Konstantinos Andreanos, Tryfon Rotsos, George Kymionis, Chryssanthi Koutsandrea, Athanasios Kotsolis, Ioannis Ladas
Purpose: To report a case of foveal neovascularization in a patient with proliferative diabetic retinopathy as seen on optical coherence tomography angiography (OCT-A). Methods: Multimodal imaging was used for diagnostic investigation. Patient: A 61-year-old male with a 16-year history of insulin-dependent diabetes mellitus was referred to our medical retina department for examination and management. Meticulous fundus examination and multimodal imaging revealed proliferative diabetic retinopathy lesions, including neovascularization located in the foveal area...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29643784/clinical-efficacy-and-safety-of-the-ex-press-filtration-device-in-patients-with-advanced-neovascular-glaucoma-and-proliferative-diabetic-retinopathy
#3
Rana Hanna, Beatrice Tiosano, Shmuel Graffi, Dan Gaton
Background: The prognosis of conventional filtration surgery in eyes with neovascular glaucoma (NVG) is limited due to increased fibrovascular proliferation or bleeding. This study aims to evaluate the safety and efficacy of the EX-PRESS filtration device in the management of NVG associated with proliferative diabetic retinopathy (PDR). Methods: In this retrospective case series, we reviewed the medical records of patients diagnosed as having NVG associated with PDR who underwent EX-PRESS filtration surgery...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29626228/venous-beading-in-two-or-more-quadrants-might-not-be-a-sensitive-grading-criterion-for-severe-nonproliferative-diabetic-retinopathy
#4
Ling Chen, Xiongze Zhang, Feng Wen
PURPOSE: To determine whether venous beading (VB) in two or more quadrants is an appropriate grading criterion for severe nonproliferative diabetic retinopathy (NPDR). METHODS: A hospital-based, retrospective, cross-sectional study. A total of 806 patients admitted with diabetic retinopathy (DR) from January 2014 to April 2017 were included in this study. DR severity was graded by the international grading criterion. The status of VB, intraretinal microvascular abnormalities (IRMA), capillary nonperfusion, arteriovenous nicking, and diabetic macular edema was evaluated based on fundus fluorescein angiography...
April 6, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29621508/angiopoietin-like-3-is-a-potential-biomarker-for-retinopathy-in-type-2-diabetic-patients
#5
Cai-Guo Yu, Sha-Sha Yuan, Long-Yan Yang, Jing Ke, Li-Jie Zhang, Jia-Nan Lang, Da-Wei Zhang, Shao-Zhen Zhao, Dong Zhao, Ying-Mei Feng
PURPOSE: To investigate whether angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) are differentially associated with the severity of retinopathy in patients with type 2 diabetes mellitus (T2DM). DESIGN: Cross-sectional study. METHODS: Serum levels of ANGPTL3, ANGPTL4, high-sensitivity C-reactive protein (CRP), vascular adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1) and vascular endothelial growth factor (VEGF) were quantified by ELISA...
April 2, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29618794/pupillary-abnormalities-with-varying-severity-of-diabetic-retinopathy
#6
Mukesh Jain, Sandeep Devan, Durgasri Jaisankar, Gayathri Swaminathan, Shahina Pardhan, Rajiv Raman
Our aim is to study the dynamics of pupillary abnormalities in varying severity of diabetic retinopathy. A non-interventional case-control study with 405 eyes of 244 subjects with diabetes, and 41 eyes of 26 subjects with no history of diabetes was done. Diabetes group was classified according to retinopathy severity: no retinopathy, mild non-proliferative diabetic retinopathy (NPDR), moderate NPDR, severe NPDR and proliferative diabetic retinopathy (PDR). After dark adaptation, pupil size and flashlight response were captured with an infrared camera...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29606379/cost-evaluation-of-early-vitrectomy-versus-panretinal-photocoagulation-and-intravitreal-ranibizumab-for-proliferative-diabetic-retinopathy
#7
James Lin, Jonathan S Chang, Nicolas A Yannuzzi, William E Smiddy
PURPOSE: To evaluate costs and cost-utility of early vitrectomy (pars plana vitrectomy [PPV]) compared with panretinal photocoagulation (PRP) and intravitreal ranibizumab (IVR) for proliferative diabetic retinopathy (PDR) without diabetic macular edema. DESIGN: A decision analysis model of cost-utility. PARTICIPANTS: There were no participants. METHODS: A decision analysis was based on results from the Diabetic Retinopathy Clinical Research Network Protocol S comparing treatment of PRP with IVR (0...
March 29, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29606377/loss-to-follow-up-in-patients-with-proliferative-diabetic-retinopathy-after-panretinal-photocoagulation-or-intravitreal-anti-vegf-injections
#8
Anthony Obeid, Xinxiao Gao, Ferhina S Ali, Katherine E Talcott, Christopher M Aderman, Leslie Hyman, Allen C Ho, Jason Hsu
PURPOSE: Loss to follow-up (LTFU) may contribute to vision loss in patients with active proliferative diabetic retinopathy (PDR). The aim of this study is to determine and compare the rates of LTFU in patients with PDR receiving panretinal photocoagulation (PRP) or intravitreal injections (IVIs) with anti-vascular endothelial growth factor (VEGF) over approximately 4 years. Moreover, this study evaluates various risk factors for LTFU. DESIGN: Retrospective cohort study...
March 29, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29599823/regional-differences-in-the-prevalence-of-diabetic-retinopathy-a-multi-center-study-in-brazil
#9
Karla Rezende Guerra Drummond, Fernando Korn Malerbi, Paulo Henrique Morales, Tessa Cerqueira Lemos Mattos, André Araújo Pinheiro, Felipe Mallmann, Ricardo Vessoni Perez, Franz Schubert Lopes Leal, Laura Gomes Nunes de Melo, Marília Brito Gomes
Background: Diabetic retinopathy has a significant impact in every healthcare system. Despite that fact, there are few accurate estimates in the prevalence of DR in Brazil's different geographic regions, particularly proliferative DR and diabetic macular edema. This study aims to determine the prevalence of diabetic retinopathy in Brazil's five continental regions and its determinant factors. Methods: This multi center, cross-sectional, observational study, conducted between August 2011 and December 2014, included patients with type 1 diabetes from the 5 Brazilian geographic regions (South, Southeast, North, Northeast and Midwest)...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29582817/diabetic-retinopathy-in-patients-with-diabetic-foot-syndrome-in-south-india
#10
Thoiba Karam, Yogish Subraya Kamath, Lavanya G Rao, Krishna Addoor Rao, Shailaja Bhat Shenoy, Sulatha V Bhandary
Purpose: The purpose was to study the retinopathy status in diabetic patients with a risk of diabetic foot (DF) syndrome visiting a tertiary care hospital in South India. Methods: In this cross sectional study all patients with diabetes mellitus (DM) with a risk of DF syndrome, visiting a tertiary care hospital during the study period, underwent an ophthalmological evaluation for documentation of their retinopathy status. Results: One hundred and eighty-two patients diagnosed to have a risk profile for DF syndrome were included in the study...
April 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29582816/prevalence-progression-and-outcomes-of-diabetic-retinopathy-during-pregnancy-in-indian-scenario
#11
Tarjani Makwana, Brijesh Takkar, Pradeep Venkatesh, Jai Bhagwan Sharma, Yashdeep Gupta, Rohan Chawla, Rajpal Vohra, Alka Kriplani, Nikhil Tandon
Purpose: The objective of this study is to evaluate pattern of diabetic retinopathy (DR) during pregnancy in females with pregestational diabetes mellitus (DM). Methods: This is an ambispective observational cohort study conducted at an Indian tertiary care centre. A total of 50 pregnant females with pregestational DM were included while those with gestational DM were excluded from the study. Ocular examination (inclusive of fundus photography) was conducted and systemic parameters (inclusive of Glycated hemoglobin) were assessed during each of the 3 trimesters and 3 months postpartum...
April 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29575757/-pro-renin-receptor-involvement-in-diabetic-retinopathy-and-development-of-molecular-targeted-therapy
#12
Atsuhiro Kanda, Susumu Ishida
The renin-angiotensin system (RAS), a crucial regulator of systemic blood pressure (circulatory RAS), plays distinct roles in pathological angiogenesis and inflammation in various organs (tissue RAS) such as diabetic microvascular complications. Using ocular clinical samples and animal disease models, we elucidated molecular mechanisms in which tissue RAS excites the expression of vascular endothelial growth factor (VEGF)-A responsible for retinal inflammation and angiogenesis, the two major pathological events in diabetic retinopathy (DR)...
March 25, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29571831/cost-evaluation-of-laser-versus-intravitreal-aflibercept-for-proliferative-diabetic-retinopathy
#13
Nicolas A Yannuzzi, Jayanth Sridhar, Jonathan S Chang, James Lin, Ajay E Kuriyan, William E Smiddy
No abstract text is available yet for this article.
March 20, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29571830/impact-of-incidence-and-progression-of-diabetic-retinopathy-on-vision-specific-functioning
#14
Preeti Gupta, Alfred Tau Liang Gan, Ryan Eyn Kidd Man, Eva K Fenwick, Neelam Kumari, Gavin Tan, Paul Mitchell, Charumathi Sabanayagam, Tien Yin Wong, Ching-Yu Cheng, Ecosse L Lamoureux
PURPOSE: To investigate the independent impact of the incidence and progression of diabetic retinopathy (DR) on visual functioning (VF). DESIGN: Population-based cohort study. PARTICIPANTS: A total of 518 participants aged 40 to 80 years (baseline visit 2007-2009 and second visit 6 years later, 2013-2015), with diabetes, clinical data, and VF information at both visits. MAIN OUTCOME MEASURES: VF-7 scores, converted to interval-level person measures (in logits) using Rasch analysis...
March 20, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29567299/association-between-self-reported-physical-activity-and-skin-autofluorescence-a-marker-of-tissue-accumulation-of-advanced-glycation-end-products-in-adults-with-type-1-diabetes-a-cross-sectional-studyt
#15
Anna Duda-Sobczak, Bogusz Falkowski, Aleksandra Araszkiewicz, Dorota Zozulinska-Ziolkiewicz
PURPOSE: The accumulation of advanced glycation end products (AGEs) in local tissue is an important cause of low-grade inflammation and oxidative stress and is linked to late diabetic complications. Physical activity has various beneficial cardiometabolic effects in type 1 diabetes (T1D) and is associated with lower frequency of chronic complications of diabetes, although the specific mechanisms still remain unclear. The present study determines the association between self-reported physical activity and skin autofluorescence (AF), a marker of tissue accumulation of AGEs in adults with T1D...
March 19, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29563110/clinical-features-of-patients-with-diabetic-anterior-uveitis
#16
Takayo Watanabe, Hiroshi Keino, Kyoko Nakayama, Wakako Taki, Nariaki Echizen, Annabelle A Okada
AIM: To describe clinical features and outcomes of new-onset anterior uveitis associated with poorly controlled or undiagnosed diabetes mellitus. METHODS: Retrospective analysis of 25 eyes of 18 patients (14 men, 4 women; mean age 44 years) who presented between December 2001 and October 2016 to the Kyorin Eye Center. RESULTS: Ocular findings at presentation included posterior synechiae (15 eyes, 60%), anterior chamber fibrin (13 eyes, 52%), keratic precipitates (10 eyes, 40%), Descemet membrane folds (7 eyes, 28%) and hypopyon (3 eyes, 12%)...
March 21, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29561498/individuals-perspectives-on-coping-with-vision-loss-from-diabetic-retinopathy
#17
Bonnie A Sturrock, Gwyneth Rees, Ecosse L Lamoureux, Tien Y Wong, Edith Holloway, Eva K Fenwick
SIGNIFICANCE: People with vision loss from diabetic retinopathy (DR) and diabetic macular edema (DME) use problem-focused and emotion-regulation strategies that may influence their short- and longer-term adaptation and psychological outcomes. Our findings can assist the development of models of adjustment to DR/DME-related vision loss and treatments focused on adaptation. PURPOSE: To qualitatively determine the coping strategies used by participants with vision loss resulting from DR/DME...
March 21, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29554658/procoagulant-activity-of-blood-and-endothelial-cells-via-phosphatidylserine-exposure-and-microparticle-delivery-in-patients-with-diabetic-retinopathy
#18
Ying Su, Jingli Chen, Zengxiang Dong, Yan Zhang, Ruishuang Ma, Junjie Kou, Feng Wang, Jialan Shi
BACKGROUND/AIMS: The mechanisms for thrombosis in diabetic retinopathy (DR) are complex and need to be further elucidated. The purpose of this study was to test phosphatidylserine (PS) exposure on microparticles (MPs) and MP-origin cells from the circulation and to analyze cell-/MP-associated procoagulant activity (PCA) in DR patients. METHODS: PS-positive MPs and cells from healthy controls (n = 20) and diabetic patients (n = 60) were analyzed by flow cytometry and confocal microscopy...
March 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29547453/asymmetric-diabetic-retinopathy-progression-in-patients-with-axial-anisometropia
#19
Dong Yoon Kim, Ji Ho Song, Yoon Jeon Kim, Joo Yong Lee, June-Gone Kim, Young Hee Yoon, Soo Geun Joe
PURPOSE: To investigate the differences in the progression of diabetic retinopathy (DR) in both eyes of patients with axial anisometropia. METHODS: A retrospective review was conducted on diabetic patients who had different axial lengths (difference greater than 1 mm) in each eye. The primary objective of this study was to analyze the differences in the progression of DR in both eyes of patients with axial anisometropia. Fundus images (fluorescein angiography and photographs of the fundus covering the Early Treatment Diabetic Retinopathy Study seven fields) were graded using the Early Treatment Diabetic Retinopathy Study DR grading system...
March 15, 2018: Retina
https://www.readbyqxmd.com/read/29543992/different-lasers-and-techniques-for-proliferative-diabetic-retinopathy
#20
REVIEW
Tanya Moutray, Jennifer R Evans, Noemi Lois, David J Armstrong, Tunde Peto, Augusto Azuara-Blanco
BACKGROUND: Diabetic retinopathy (DR) is a chronic progressive disease of the retinal microvasculature associated with prolonged hyperglycaemia. Proliferative DR (PDR) is a sight-threatening complication of DR and is characterised by the development of abnormal new vessels in the retina, optic nerve head or anterior segment of the eye. Argon laser photocoagulation has been the gold standard for the treatment of PDR for many years, using regimens evaluated by the Early Treatment of Diabetic Retinopathy Study (ETDRS)...
March 15, 2018: Cochrane Database of Systematic Reviews
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