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Proliferative diabetic retinopathy

Ji Hyun Lee, Ju Hee Han, Kyung Do Han, Young Min Park, Jun Young Lee, Yong-Gyu Park, Young Bok Lee
Psoriasis is a chronic cutaneous disease known to be related with systemic disease; however, the association between psoriasis and diabetic complications has not been previously reported. Diabetic microvascular complications include diabetic retinopathy (DR), nephropathy, and neuropathy, and overt diabetic nephropathy can lead to the end-stage renal disease (ESRD).The present study investigated the association between psoriasis and non-proliferative DR (NPDR) or proliferative DR (PDR) or ESRD. We analyzed the relationship between diabetic complication and psoriasis using data from the National Health Insurance Service between 2009 and 2015...
June 14, 2018: Scientific Reports
Thomas S Hwang, Ahmed M Hagag, Jie Wang, Miao Zhang, Andrew Smith, David J Wilson, David Huang, Yali Jia
Importance: Diabetic retinopathy (DR) is a leading cause of vision loss that is managed primarily through qualitative clinical examination of the retina. Optical coherence tomography angiography (OCTA) may offer an objective and quantitative method of evaluating DR. Objective: To quantify capillary nonperfusion in 3 vascular plexuses in the macula of eyes patients with diabetes of various retinopathy severity using projection-resolved OCTA (PR-OCTA). Design, Setting, and Participants: Cross-sectional study at a tertiary academic center comprising 1 eye each from healthy control individuals and patients with diabetes at different severity stages of retinopathy...
June 14, 2018: JAMA Ophthalmology
Liang Li, Pu Zhang, Hong Liu, Yu-Hua Liu, Ling Gao
PURPOSE: To investigate multispectral imaging (MSI) as a novel diagnostic approach for diabetic retinopathy (DR) in clinic. METHODS: A total of 50 Type-2 diabetic patients (99 eyes) were enrolled in this cross-sectional study. All subjects underwent digital fundus photography (DFP), MSI, and fundus fluorescein angiography. A total exact agreement, sensitivity, specificity, positive predictive value, and negative predictive value of no DR/mild nonproliferative diabetic retinopathy (NPDR) and severe NPDR/proliferative diabetic retinopathy (PDR) grading were calculated based on DFP and MSI and were compared with fundus fluorescein angiography...
June 12, 2018: Retina
Natasa Popovic, Miroslav Radunovic, Jelena Badnjar, Tomo Popovic
In this article we present a data set that contains 37 image files obtained by manual vessel segmentation of raw retinal images from Structured Analysis of the Retina (STARE) database ("The STARE Project", 2018) [1]. Our expert segmented 8 images that are associated with the single diagnosis of hypertensive retinopathy and 9 images with the single diagnosis of proliferative diabetic retinopathy (Popovic et al., 2018) [2]. To validate the manual segmentation, the same expert additionally segmented a gold standard set of 20 raw images from the STARE database...
June 2018: Data in Brief
Peige Song, Jinyue Yu, Kit Yee Chan, Evropi Theodoratou, Igor Rudan
Background: Diabetic retinopathy (DR), the primary retinal vascular complication of diabetes mellitus (DM), is a leading cause of vision impairment and blindness in working-age population globally. Despite mounting concerns about the emergence of DM as a major public health problem in the largest developing country, China, much remains to be understood about the epidemiology of DR. We aimed to investigate the prevalence of and risk factors for DR, and estimate the burden of DR in China in 2010...
June 2018: Journal of Global Health
Ma Ludivina Robles-Osorio, Renata García-Franco, Carlos D Núñez-Amaro, Ximena Mira-Lorenzo, Paulina Ramírez-Neria, Wendy Hernández, Ellery López-Star, Thomas Bertsch, Gonzalo Martínez de la Escalera, Jakob Triebel, Carmen Clapp
Background: Diabetic retinopathy (DR) and diabetic macular edema (DME) are potentially blinding, microvascular retinal diseases in people with diabetes mellitus. Preclinical studies support a protective role of the hormone prolactin (PRL) due to its ocular incorporation and conversion to vasoinhibins, a family of PRL fragments that inhibit ischemia-induced retinal angiogenesis and diabetes-derived retinal vasopermeability. Here, we describe the protocol of an ongoing clinical trial investigating a new therapy for DR and DME based on elevating the circulating levels of PRL with the prokinetic, dopamine D2 receptor blocker, levosulpiride...
2018: Frontiers in Endocrinology
Tammy Z Movsas, Kwoon Y Wong, Michael D Ober, Robert Sigler, Zhenmin M Lei, Arivalagan Muthusamy
Luteinizing hormone (LH), produced in the anterior pituitary, has been detected in cadaver eyes and LH receptors (LHRs) have been identified in the retina, with the highest density in cone photoreceptors. Our aim was to confirm the presence of LH in the living, human eye as well as to examine the potential impact of a reduction in LHR signaling on visual processing. Vitreous samples were collected from 40 patients (23 diabetics, 17 non-diabetics) who were undergoing vitrectomies for various indications. LH concentration was quantified in each sample via an electro-chemiluminescence immunoassay and Meso Scale Discovery platform and normalized to total protein...
June 8, 2018: Neuroscience
Nathan R Haines, Niranjan Manoharan, Jeffrey L Olson, Angelo D'Alessandro, Julie A Reisz
The vitreous humor is a highly aqueous eye fluid interfacing with the retina and lens and providing shape. Its molecular composition provides a readout for the eye's physiological status. Changes in cellular metabolism underlie vitreoretinal pathologies, but despite routine surgical collection of vitreous, only limited reports of metabolism in the vitreous of human patients have been described. Here, vitreous samples from patients with rhegmatogenous retinal detachment (n=25) and proliferative diabetic retinopathy (n=9) were profiled along with control human vitreous samples (n=8) by untargeted mass spectrometry-based metabolomics...
June 7, 2018: Journal of Proteome Research
Gail Musen, Liane J Tinsley, Katrina A Marcinkowski, David Pober, Jennifer K Sun, Maya Khatri, Richie Huynh, Annie Lu, George L King, Hillary A Keenan
OBJECTIVE: Patients with type 1 diabetes now live long enough to experience cognitive decline. During middle age, they show mild cognitive deficits, but it is unknown whether severity increases with aging or whether cognitive profiles are similar to those of age-matched peers with and without diabetes. RESEARCH DESIGN AND METHODS: We tested and compared cognition in 82 individuals with 50 or more years of type 1 diabetes (Medalists), 31 age-matched individuals with type 2 diabetes, and 30 age-matched control subjects without diabetes...
June 5, 2018: Diabetes Care
Leonardo Provetti Cunha, Evelyn Alvernaz Figueiredo, Henrique Pereira Araújo, Luciana Virgínia Ferreira Costa-Cunha, Carolina Ferreira Costa, José de Melo Costa Neto, Aline Mota Freitas Matos, Marise Machado de Oliveira, Marcus Gomes Bastos, Mário Luiz Ribeiro Monteiro
Purpose: To determine the level of agreement between trained family physicians (FPs), general ophthalmologists (GOs), and a retinal specialist (RS) in the assessment of non-mydriatic fundus retinography in screening for diabetic retinopathy (DR) in the primary health-care setting. Methods: 200 Diabetic patients were submitted to two-field non-mydriatic digital fundus camera. The images were examined by four trained FPs, two GOs, and one RS with regard to the diagnosis and severity of DR and the diagnosis of macular edema...
2018: Frontiers in Endocrinology
Songfu Feng, Honghua Yu, Ying Yu, Yu Geng, Dongli Li, Chun Yang, Qingjun Lv, Li Lu, Ting Liu, Guodong Li, Ling Yuan
Diabetic retinopathy is the leading cause of blindness in working age individuals in developed countries. However, the role of inflammation in the pathogenesis of DR is not completely understood. This is an observational clinical research enrolling 80 type II diabetic patients who had undergone cataract surgeries either with DR or without DR. All cases were further categorized by the proliferative stages of retinal neovascularization and by the lengths of diabetic history. The levels of inflammatory cytokines including IL-1 β , IL-6, IL-8, IL-17, and TNF- α in aqueous humour were tested...
2018: Journal of Diabetes Research
Joanna Stafiej, Karolina Kaźmierczak, Katarzyna Linkowska, Paweł Żuchowski, Tomasz Grzybowski, Grażyna Malukiewicz
Purpose: To evaluate the expression profiles of the VEGF α and TGF β in the ERMs and ILMs in retinal disorders. Methods: In this nonrandomized prospective study, 75 patients (34 females and 41 males) referred to pars plana vitrectomy (PPV) due to different retinal diseases were enrolled to the study. The samples of ERMs and ILMs collected during PPV were immediately put in TRIzol® Reagent (Life Technologies, USA) and stored at -70°C until RNA extraction. Gene expression analysis was done with TaqMan® Gene Expression Assays (Applied Biosystems, USA) following the manufacturer's instructions...
2018: Journal of Ophthalmology
Heng Miao, Xianru Hou, De-Kuang Hwang, Yong Tao
Objective: To determine the expression of cytokines in the iris of patients with neovascular glaucoma (NVG). Methods: Patients with NVG associated with proliferative diabetic retinopathy (PDR, group 1) or central retinal vein occlusion (CRVO, group 2) who had undergone surgical treatment were enrolled. Patients with primary open-angle glaucoma requiring surgical treatment were included in the control group (group 3). All iris specimens were obtained during trabeculectomy, 7 days after intravitreal injections of ranibizumab...
2018: Journal of Ophthalmology
Chen Zou, Minjie Zhao, Jingjing Yu, Dandan Zhu, Yunzhi Wang, Xinping She, Yanan Hu, Zhi Zheng
Purpose: To examine the difference in the vitreal protein profiles of patients with proliferative diabetic retinopathy (PDR) with and without preoperative intravitreal conbercept (IVC) treatment. Methods: Liquid chromatography-tandem mass spectrometry- (LC-MS/MS-) based proteomic methods were used to determine the protein profiles of the vitreous humor in patients with PDR treated with (IVC group; n = 9) and without (PDR group; n = 8) preoperative IVC. Gene ontology (GO) annotation and REACTOME pathway analysis were obtained to overview differentially expressed proteins between each group...
2018: Journal of Ophthalmology
Jin-Song Zhao, Hui-Xiang Jin, Jia-Lin Gao, Chun Pu, Peng Zhang, Jian-Jun Huang, Long Cheng, Gang Feng
Extracellular superoxide dismutase (ecSOD) is the major extracellular scavenger of reactive oxygen species and associated with the diabetic complication in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the serum ecSOD activity in Chinese patients with different stages of diabetic retinopathy (DR) and evaluate the association between the serum ecSOD activity and the severity of DR. A total of 343 T2DM patients were categorized into three groups: nondiabetic retinopathy (NDR) group, nonproliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group...
2018: Disease Markers
Sharanjeet-Kaur, Siti-Aishah Ismail, Haliza Abdul Mutalib, Nor Fariza Ngah
PURPOSE: The purpose of this study was to determine the relationship between HbA1c values and retinal sensitivity at central 10° using the MP-1 microperimeter. METHODS: A prospective study was carried out on 32 healthy subjects (control group) and 60 diabetic patients. The diabetic patients were divided into 2 groups. Group 1 comprised of 30 patients without diabetic retinopathy (DR) and group 2 had 30 patients with mild non-proliferative DR. A full-threshold microperimetry of the central 10° of retina (the macula) was performed on all subjects, utilizing 32 points with the MP-1...
May 26, 2018: Journal of Optometry
Jiandong Pan, Ding Chen, Xiaoling Yang, Ruitao Zou, Kuo Zhao, Dan Cheng, Shenghai Huang, Tingye Zhou, Ye Yang, Feng Chen
PURPOSE: To classify retinal neovascularization in untreated early stages of proliferative diabetic retinopathy (PDR) based on optical coherence tomography angiography (OCTA). DESIGN: A cross-sectional study. METHODS: Thirty-five eyes were included. They underwent color fundus photography, fluorescein angiography (FA), and OCTA examinations. Neovascularizations elsewhere (NVEs), neovascularizations of the optic disc (NVDs), and intraretinal microvascular abnormalities (IRMAs) were scanned by OCTA...
May 25, 2018: American Journal of Ophthalmology
Alex C Onishi, Peter L Nesper, Philipp K Roberts, Ganna A Moharram, Haitao Chai, Lei Liu, Lee M Jampol, Amani A Fawzi
Purpose: To quantify microvasculature changes in the superficial (SCP), middle (MCP), and deep capillary plexuses (DCP) in diabetic retinopathy (DR). Methods: Retrospective cross-sectional study at a tertiary academic referral center, in which 26 controls (44 eyes), 27 diabetic subjects without retinopathy (44 eyes), 32 subjects with nonproliferative retinopathy (52 eyes), and 27 subjects with proliferative retinopathy (40 eyes) were imaged with optical coherence tomography angiography (OCTA)...
April 1, 2018: Investigative Ophthalmology & Visual Science
Bénédicte Dupas, Wilfried Minvielle, Sophie Bonnin, Aude Couturier, Ali Erginay, Pascale Massin, Alain Gaudric, Ramin Tadayoni
Importance: Capillary dropout is a hallmark of diabetic retinopathy, but its role in visual loss remains unclear. Objective: To examine how macular vessel density is correlated with visual acuity (VA) in patients younger than 40 years who have type 1 diabetes without macular edema but who have diabetic retinopathy requiring panretinal photocoagulation. Design, Settings, and Participants: Retrospective cohort study of VA and optical coherence tomography angiography data collected from consecutive patients during a single visit to Lariboisière Hospital, a tertiary referral center in Paris, France...
May 10, 2018: JAMA Ophthalmology
Frank L Brodie, Michael I Seider
No abstract text is available yet for this article.
May 24, 2018: JAMA Ophthalmology
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