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Proliferative diabetic retinopathy

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https://www.readbyqxmd.com/read/29470566/comparison-of-subjective-assessment-and-precise-quantitative-assessment-of-lesion-distribution-in-diabetic-retinopathy
#1
Connie Martin Sears, Muneeswar G Nittala, Chaitra Jayadev, Michael Verhoek, Alan Fleming, Jano van Hemert, Irena Tsui, SriniVas R Sadda
Importance: Predominantly peripheral disease in eyes with nonproliferative diabetic retinopathy (DR) is suggested as a potential strong risk factor for progression to proliferative disease. However, the reliability and optimal method for the assessment of lesion distribution are still uncertain. Objective: To compare agreement between subjective assessment and precise quantification of lesion burden in ultrawidefield (UWF) images of eyes with DR. Design, Setting, and Participants: This multisite cross-sectional study examines UWF pseudocolor images acquired from DR screening clinic patients from December 20, 2014, through August 1, 2014...
February 22, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29468217/ranibizumab-induced-retinal-reperfusion-and-regression-of-neovascularization-in-diabetic-retinopathy-an-angiographic-illustration
#2
Shruti Chandra, Jay Sheth, Giridhar Anantharaman, Mahesh Gopalakrishnan
Purpose: To report regression of neovascularization and reperfusion of ischemic areas of the retina on Wide-field Digital Fluorescein Angiography following anti-vascular endothelial growth factor injections in a patient with active Proliferative Diabetic Retinopathy. Observations: Case report of sixty-one-year-old male patient with proliferative diabetic retinopathy and diabetic macular edema documented on wide field digital fluorescein angiography. The patient was treated with three intravitreal injections of ranibizumab given at monthly intervals...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29468214/optical-coherence-tomography-angiography-showing-perifoveal-capillary-stability-30-years-after-fluorescein-angiography
#3
Nikisha Kothari, Nidhi Relhan, Harry W Flynn
Purpose: To report the Optical Coherence Tomography Angiography (OCTA) results as a novel non-invasive diagnostic modality which provides useful information regarding the status of blood flow in diabetic retinopathy. The current study is a long-term follow-up of eyes of patients with proliferative diabetic retinopathy managed with panretinal photocoagulation. Observations: Two patients with proliferative diabetic retinopathy (PDR) were treated with panretinal photocoagulation (PRP) in both eyes in the early 1980s...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29463954/association-of-plasma-osteopontin-with-diabetic-retinopathy-in-asians-with-type-2-diabetes
#4
Xiao Zhang, Wai Kitt Chee, Sylvia Liu, Subramaniam Tavintharan, Chee Fang Sum, Su Chi Lim, Neelam Kumari
Purpose: Osteopontin (OPN) is a proinflammatory cytokine with diverse functions. Increased levels of OPN in vitreous fluid have been reported in patients with diabetic retinopathy (DR); however, studies on circulating OPN levels in DR are limited. We aim to examine the association of plasma OPN levels with the presence and severity of DR in a multiethnic cohort with type 2 diabetes mellitus (type 2 diabetes) in Singapore. Methods: Plasma levels of OPN were measured using enzyme-linked immunosorbent assay...
2018: Molecular Vision
https://www.readbyqxmd.com/read/29461171/new-model-of-proliferative-vitreoretinopathy-in-rabbit-for-drug-delivery-and-pharmacodynamic-studies
#5
Sang Woong Moon, Yaoyao Sun, David Warther, Kristyn Huffman, William R Freeman, Michael J Sailor, Lingyun Cheng
Blinding retinal diseases become more epidemic as the population ages. These diseases, such as diabetic retinopathy and macular edema, are of chronic nature and require protracted drug presence at the disease site. A sustained intravitreal porous silicon delivery system with dexamethasone (pSiO2 -COO-DEX) was evaluated in a new rabbit model of proliferative vitreoretinopathy (PVR) in a real treatment design. In contrast to the pretreatment design model, pSiO2 -COO-DEX was intravitreally injected into the eyes with active inflammation...
January 1, 2018: Drug Delivery
https://www.readbyqxmd.com/read/29460018/observation-of-neovascularization-of-the-disc-associated-with-proliferative-diabetic-retinopathy-using-oct-angiography
#6
Hideo Akiyama, Danjie Li, Yukitoshi Shimoda, Hidetaka Matsumoto, Shoji Kishi
PURPOSE: To describe the relationship between the vitreous and the neovascularization of the disc (NVD) using swept source optical coherence tomography (SS-OCT) and OCT angiography (OCTA). STUDY DESIGN: Retrospective. METHODS: We examined 17 eyes of 11 consecutive patients diagnosed as NVD associated with proliferative diabetic retinopathy (PDR). The location of the NVD feeder or collector vessels were examined by using RTVue XR Avanti. To determine the condition of the posterior vitreous detachment (PVD) and the proliferative tissue of the NVD, we performed 12 mm horizontal and vertical scans through the disc using SS-OCT...
February 19, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29456428/strategies-to-improve-prevention-and-management-in-diabetic-retinopathy-qualitative-insights-from-a-mixed-methods-study
#7
Richard S Beaser, Wendy A Turell, Alexandra Howson
Nonproliferative and proliferative diabetic retinopathy (DR) are common, progressive complications of diabetes with a rising incidence. Over time, patients with nonproliferative DR may progress to more advanced stages of DR, with an increased risk of vision-threatening conditions such as diabetic macular edema (DME). DME is the most frequent cause of vision loss in patients with diabetes and eventually can lead to blindness. Early-stage DR is asymptomatic; therefore, a coordinated management strategy is crucial to prevent or limit the progression of DR...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29450537/enhanced-expression-of-nlrp3-inflammasome-related-inflammation-in-diabetic-retinopathy
#8
Hui Chen, Xiongze Zhang, Nanying Liao, Lan Mi, Yuting Peng, Bing Liu, Shaochong Zhang, Feng Wen
Purpose: The aim of this study was to determine the association between nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) family, pyrin domain-containing 3 (NLRP3) inflammasome-induced inflammation and disease severity in diabetic retinopathy (DR). Methods: Blood samples were collected from 64 patients with diabetes (DR, 43; without DR, 21) and 25 healthy controls. The protein and mRNA expression levels of NLRP3 inflammasomes in peripheral blood mononuclear cells were determined using western blotting and quantitative real-time reverse transcription-PCR...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29445713/effects-of-laser-physical-parameters-on-lesion-size-in-retinal-photocoagulation-surgery-clinical-oct-and-experimental-study
#9
A Soleimani, S H Rasta, T Banaei, A Asgharsharghi Bonab
Introduction: The aim of the present study was to determine burn intensity in retinal laser photocoagulation based on laser parameters; wavelength, power, beam size and pulse duration, using Optical Coherence Tomography (OCT), fundus camera, physical eye model and computer simulation in a clinical study. Materials and Methods: Participants were 10 adult patients between 50-80 years with proliferative diabetic retinopathy. A multicolor-photo coagulator with 532 nm green and 672 nm red for retina photocoagulation in diabetic retinopathy was used to investigate the participants...
December 2017: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/29434227/the-nlrp3-inflammasome-may-contribute-to-pathologic-neovascularization-in-the-advanced-stages-of-diabetic-retinopathy
#10
Shyam S Chaurasia, Rayne R Lim, Bhav H Parikh, Yeo Sia Wey, Bo Bo Tun, Tien Yin Wong, Chi D Luu, Rupesh Agrawal, Arkasubhra Ghosh, Alessandra Mortellaro, Elizabeth Rackoczy, Rajiv R Mohan, Veluchamy A Barathi
Diabetic retinopathy (DR) is a retinal microvascular disease characterized by inflammatory and angiogenic pathways. In this study, we evaluated NLRP3 inflammasome in a double transgenic mouse model, Akimba (Ins2 Akita xVEGF +/- ), which demonstrates hyperglycemia, vascular hyperpermeability and neovascularization seen in the proliferative DR. Retinal structural integrity, vascular leakage and function were examined by fundus photography, fluorescein angiography, optical coherence tomography, retinal flat mounts, laser speckle flowgraphy (LSFG), and electroretinography in Akimba and its parental strains, Akita (Ins2 Akita ) and Kimba (trVEGF029) mice...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29430477/automated-segmentation-of-hyperreflective-foci-in-spectral-domain-optical-coherence-tomography-with-diabetic-retinopathy
#11
Idowu Paul Okuwobi, Wen Fan, Chenchen Yu, Songtao Yuan, Qinghuai Liu, Yuhan Zhang, Bekalo Loza, Qiang Chen
We propose an automated segmentation method to detect, segment, and quantify hyperreflective foci (HFs) in three-dimensional (3-D) spectral domain optical coherence tomography (SD-OCT). The algorithm is divided into three stages: preprocessing, layer segmentation, and HF segmentation. In this paper, a supervised classifier (random forest) was used to produce the set of boundary probabilities in which an optimal graph search method was then applied to identify and produce the layer segmentation using the Sobel edge algorithm...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29429414/rapidly-progressive-neovascular-glaucoma-following-coronary-artery-bypass-graft-surgery-in-a-patient-with-type-1-diabetes-mellitus-a-case-report
#12
Vasant Raman, Rosemary Lambley
BACKGROUND: Proliferative diabetic retinopathy leading to vitreous hemorrhage, tractional retinal detachment, and neovascular glaucoma is a major cause of severe sight impairment in adults of working age worldwide. Neovascular glaucoma occurs in 2.5% of patients with proliferative diabetic retinopathy, which is difficult to treat and often leads to blindness. Onset of neovascular glaucoma with rapid progression to blindness within a few weeks of a successful coronary artery bypass graft procedure is not known with this clinical entity...
February 12, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29429256/-prevalence-and-risk-factors-of-diabetic-retinopathy-in-hospital-patients
#13
Y Zhang, M Niu, Y Li, J Wang, B Qu, C X Zheng, P Huang, W H Yu
Objective: To analyze the prevalence and risk factors of diabetic retinopathy (DR) in ophthalmic patients. Methods: A cross-sectional study was performed. Diabetic patients who were admitted to Department of Ophthalmology, Traditional Chinese Medicine Hospital of Muping between October 2012 and June 2013 were included. General information and medical history were obtained from each subject by questionaires. Laboratory and detailed ophthalmic examinations were performed during the study. DR was diagnosed and graded by mydriatic fundus photography...
February 6, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29420143/complications-of-intravitreous-injections-in-patients-with-diabetes
#14
Aditi Gupta, Jennifer K Sun, Paolo S Silva
Intravitreous injections are presently the second most frequently performed ophthalmic procedure and the most common vitreoretinal procedure. In diabetic patients, intravitreous injections are frequently performed for the treatment of center-involved diabetic macular edema, proliferative diabetic retinopathy, or other co-existing retinal vascular disease. Diabetic patients may be at higher risk of adverse events compared to non-diabetic individuals, given frequent systemic comorbidities, such as cardiovascular and renal disease and increased susceptibility to infection...
2018: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29412501/region-specific-ischemia-neovascularization-and-macular-edema-in-treatment-na%C3%A3-ve-proliferative-diabetic-retinopathy
#15
Jason Lange, Majda Hadziahmetovic, Jingfa Zhang, Weiye Li
IMPORTANCE: Region-specific pathology in proliferative diabetic retinopathy enhances our understanding and management of this disease. BACKGROUND: To investigate non-perfusion, neovascularization, and macular edema. DESIGN: A cross-sectional, observational, non-randomized study. PARTICIPANTS: Consecutive 43 eyes of 27 treatment-naïve patients. METHODS: Ultra-widefield fluorescein angiography for studying specific zones, i...
February 7, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29408756/plasma-metabolic-profile-reveals-pgf2%C3%AE-protecting-against-non-proliferative-diabetic-retinopathy-in-patients-with-type-2-diabetes
#16
Liyuan Peng, Bei Sun, Mingming Liu, Jing Huang, Yajin Liu, Zipeng Xie, Jinlong He, Liming Chen, Daowen Wang, Yi Zhu, Xu Zhang, Ding Ai
Diabetic retinopathy (DR) is the most frequent microvascular complications of diabetes and the leading cause of blindness in adults worldwide. Non-proliferative DR (NPDR) is the first stage of DR but currently has few recommended intervention. Eicosanoids play important roles in maintaining vessel homeostasis. However, the functions of eicosanoids in NPDR are still unknown. In this study, we investigated the eicosanoids profile difference in plasma between type 2 diabetes with NPDR or not. A total of 50 patients with type 2 diabetes were recruited and divided into non-DR (NDR) group and NPDR group based on fundus photographs...
February 1, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29406470/bimanual-microincision-vitreous-surgery-for-severe-proliferative-diabetic-retinopathy-outcome-in-more-than-300-eyes
#17
Cyrus M Shroff, Charu Gupta, Daraius Shroff, Neelam Atri, Priyanka Gupta, Ranjan Dutta
PURPOSE: To evaluate the visual and anatomical outcomes and safety of bimanual microincision vitreous surgery for severe proliferative diabetic retinopathy. METHODS: Retrospective review of 315 eyes of 282 patients who underwent 23-gauge or 25-gauge pars plana vitrectomy with bimanual membrane dissection for diabetic tractional detachment from January 2007 to September 2016. Minimum follow-up was 3 months, and the average duration of follow-up was 23 months (range 3-100 months; median 15 months)...
February 5, 2018: Retina
https://www.readbyqxmd.com/read/29405370/diabetic-retinopathy-in-a-remote-indigenous-primary-healthcare-population-a-central-australian-diabetic-retinopathy-screening-study-in-the-telehealth-eye-and-associated-medical-services-network-project
#18
L Brazionis, A Jenkins, A Keech, C Ryan, A Brown, J Boffa, S Bursell
AIM: To determine diabetic retinopathy prevalence and severity among remote Indigenous Australians. METHODS: A cross-sectional diabetic retinopathy screening study of Indigenous adults with Type 2 diabetes was conducted by locally trained non-ophthalmic retinal imagers in a remote Aboriginal community-controlled primary healthcare clinic in Central Australia and certified non-ophthalmic graders in a retinal grading centre in Melbourne, Australia. The main outcome measure was prevalence of any diabetic retinopathy and sight-threatening diabetic retinopathy...
February 6, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29404861/therapeutic-potential-of-curcumin-in-major-retinal-pathologies
#19
REVIEW
Krishi V Peddada, A'sha Brown, Vivek Verma, Marcella Nebbioso
PURPOSE: The retina is continually exposed to free radicals from its rich blood supply, numerous mitochondria, and photons of light which strike its surface. Most pathological processes that take place in the retina, such as inflammation, cell apoptosis, or angiogenesis, can hence involve free radicals directly or indirectly.  Since inflammatory and oxidative stress pathways underlie retinal pathology, compounds that address these factors are therefore natural choices for treatment. This review article summarizes and provides commentary on curcumin's therapeutic potential use in ophthalmology with principal focus on retinal dosorders...
February 5, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29402461/mesenchymal-stromal-stem-cells-as-potential-therapy-in-diabetic-retinopathy
#20
REVIEW
Agnese Fiori, Vincenzo Terlizzi, Heiner Kremer, Julian Gebauer, Hans-Peter Hammes, Martin C Harmsen, Karen Bieback
Diabetic retinopathy (DR) is a multifactorial microvascular disease induced by hyperglycemia and subsequent metabolic abnormalities. The resulting cell stress causes a sequela of events that ultimately can lead to severe vision impairment and blindness. The early stages are characterized by activation of glia and loss of pericytes, endothelial cells (EC) and neuronal cells. The integrity of the retinal microvasculature becomes affected, and, as a possible late response, macular edema may develop as a common reason for vision loss in patients with non-proliferative DR...
February 2, 2018: Immunobiology
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