keyword
MENU ▼
Read by QxMD icon Read
search

Best

keyword
https://www.readbyqxmd.com/read/29166752/immunotherapy-treatment-an-issue-for-metabolic-response
#1
Luca Tagliabue, Antonella Capozza, Claudio Maioli, Andrea Luciani, Anna M Ierardi, Gianpaolo Carrafiello
Since the beginning of second decade of this century, when it was introduced in many oncologic scenarios, immunotherapy has become an important tool in the management of a growing number of cancers. Engaging the host immune system in cancer therapy seems to be useful, improving not only progression free survival but also overall survival, until the achieving the goal that many advanced cancers, previously considered without effective treatment options, have now become successfully treatable. Moreover, considering the relatively recent introduction of these drugs in clinical scenarios and the continuous releasing of new drugs, large validated clinical experiences are lacking and many issues are today debated; by the way, the evaluation of the response to immune-therapy poses major concerns...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166717/-left-atrial-appendage-volume-is-a-valuable-predictor-of-atrial-fibrillation-recurrence-after-radiofrequency-catheter-ablation
#2
G A Zheng, C Y Lin, L Weng, J D Chen
Objective: To investigate the association between the left atrial appendage (LAA) volume and atrial fibrillation (AF) recurrence after radiofrequency catheter ablation. Methods: We prospectively enrolled sixty-two patients with AF (40 cases with paroxysmal AF, 22 cases with persistent AF) who successfully underwent a first AF catheter ablation and had performed contrast-enhanced cardiac computed tomography (CT) prior to the procedure to measure LAA volumes in our hospital from January 2012 to August 2015. Circumferential pulmonary vein isolation was performed under the guidance of three-dimension mapping system (CARTO system)...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166638/predictors-of-surgical-outcomes-of-traumatic-peripheral-nerve-injuries-in-children-an-institutional-experience
#3
Bhagavatula Indira Devi, Subhas K Konar, Dhananjaya I Bhat, Dhaval P Shukla, R Bharath, M S Gopalakrishnan
AIM: This study was undertaken to address the epidemiological characteristics, operative details, and surgical outcome of peripheral nerve injuries in children treated in a tertiary hospital in India (NIMHANS, Bangalore). MATERIALS AND METHODS: This is a retrospective study of epidemiology, operative findings, and surgical outcomes over the period of 2000-2016. Our series includes 102 children with peripheral nerve injuries of various causes. RESULTS: Intramuscular injections were the most common cause (52...
November 23, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29166547/chemical-metabolome-assay-by-high-resolution-orbitrap-mass-spectrometry-and-assessment-of-associated-antitumoral-activity-of-actinocephalus-divaricatus
#4
Ana C Zanatta, Angela Mari, Milena Masullo, Iracilda Zeppone Carlos, Wagner Vilegas, Sonia Piacente, Lourdes Campaner Dos Santos
RATIONALE: Actinocephalus divaricatus (Eriocaulaceae) is an important source of income for the rural communities as it is sold as an ornamental plant. To date, no investigation has been conducted concerning the chemical composition and biological studies of the aerial parts of A. divaricatus. METHODS: The methanolic extract of the aerial parts of this species was chemically characterized. We applied an analytical dereplication approach based on Liquid Chromatography coupled to High Resolution Orbitrap Mass Spectrometry in order to develop, identify and define rapidly the metabolite fingerprint of the aerial parts of A...
November 22, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29166413/comprehensive-molecular-profiling-of-718-multiple-myelomas-reveals-significant-differences-in-mutation-frequencies-between-african-and-european-descent-cases
#5
Zarko Manojlovic, Austin Christofferson, Winnie S Liang, Jessica Aldrich, Megan Washington, Shukmei Wong, Daniel Rohrer, Scott Jewell, Rick A Kittles, Mary Derome, Daniel Auclair, David Wesley Craig, Jonathan Keats, John D Carpten
Multiple Myeloma (MM) is a plasma cell malignancy with significantly greater incidence and mortality rates among African Americans (AA) compared to Caucasians (CA). The overall goal of this study is to elucidate differences in molecular alterations in MM as a function of self-reported race and genetic ancestry. Our study utilized somatic whole exome, RNA-sequencing, and correlated clinical data from 718 MM patients from the Multiple Myeloma Research Foundation CoMMpass study Interim Analysis 9. Somatic mutational analyses based upon self-reported race corrected for ancestry revealed significant differences in mutation frequency between groups...
November 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29166386/you-prime-what-you-code-the-faim-model-of-priming-of-pop-out
#6
Wouter Kruijne, Martijn Meeter
Our visual brain makes use of recent experience to interact with the visual world, and efficiently select relevant information. This is exemplified by speeded search when target- and distractor features repeat across trials versus when they switch, a phenomenon referred to as intertrial priming. Here, we present fAIM, a computational model that demonstrates how priming can be explained by a simple feature-weighting mechanism integrated into an established model of bottom-up vision. In fAIM, such modulations in feature gains are widespread and not just restricted to one or a few features...
2017: PloS One
https://www.readbyqxmd.com/read/29166354/smoothing-the-transition-points-in-canadian-medical-education
#7
Nick Busing, Jay Rosenfield, Kamal Rungta, Matt Raegele, Andrew Warren, Bruce Wright, Mark Walton, Ivy Oandasan, Anthony Sanfilippo, Anurag Saxena
In 2010 the Association of Faculties of Medicine of Canada, Collège des médecins du Québec, College of Family Physicians of Canada, and the Royal College of Physicians and Surgeons of Canada launched The Future of Medical Education in Canada Postgraduate (FMEC PG) Project to examine postgraduate medical education (PGME) in Canada and make recommendations for improvement. One recommendation that emerged concerns the transitions learners experience across the undergraduate medical education-PGME-practice continuum...
November 21, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29166310/universal-applicability-of-the-furlow-palatoplasty-resident-as-primary-surgeon-in-a-consecutive-nonselective-series
#8
Mitchell A Stotland, Thanapoom Boonipat, Cheryl M Lundgren, Esperanza Garcia Gonzalo
BACKGROUND: Questions persist regarding the general applicability of the Furlow palatoplasty technique, and thus, widespread adoption of its use has been uneven. This study describes a consecutive, nonselective series of primary Furlow palatoplasties. Highlighted is the unique fact that plastic surgical residents functioned as the primary surgeon for all steps of all procedures throughout the series. METHODS: A retrospective review was undertaken of all primary palatoplasties performed under the direction of the senior surgeon between December 2005 and April 2012...
November 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29166294/roles-and-experiences-of-parents-in-necrotizing-enterocolitis-an-international-survey-of-parental-perspectives-of-communication-in-the-nicu
#9
Samir K Gadepalli, Jennifer Canvasser, Yael Eskenazi, Megan Quinn, Jae H Kim, Sheila M Gephart
BACKGROUND: Although partnering with parents is important to improving neonatal outcomes, no studies have investigated what parents are taught, remember, or experience when their child is afflicted with necrotizing enterocolitis (NEC). PURPOSE: To characterize parental perceptions of communication and support they were given about NEC. METHODS: An online survey was developed, reviewed for face validity, and then administered to parents whose child had experienced NEC...
November 20, 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/29166285/an-evaluation-of-the-usefulness-of-invasive-and-non-invasive-methods-used-to-diagnose-helicobacter-spp-infections-in-dogs
#10
M Jankowski, J Spużak, K Kubiak, K Glińska-Suchocka, M Biernat
The aim of this study was to assess the suitability of invasive and non-invasive methods used to diagnose Helicobacter spp. in the stomachs of dogs. The study was carried out on 30 dogs of both sexes and different breeds, between one and 15 years old. A histopathologic examination, a microbiological culture, a rapid urease test, a direct bacteriological preparation and a nested PCR assay were carried out. Gastric Helicobacter spp. was identified in gastric biopsy specimens from 16 (53.3%) dogs using direct bacteriological preparation, in four (13...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29166260/the-development-and-content-validation-of-a-multidisciplinary-evidence-based-wound-infection-prevention-and-treatment-guideline
#11
Sammy A Zakhary, Chris Davey, Rebecca Bari, Jordan Bean, Tyler Reber, Kathy Gallagher, Kara Couch, Jennifer Hurlow, Karen Laforet, Corrine McIssac, Karen Napier, Diana Vilar-Compte, Emily Zakhary, Michel Hermans, Laura Bolton
Acute and chronic wound infections create clinical, economic, and patient-centered challenges best met by multidisciplinary wound care teams providing consistent, valid, clinically relevant, safe, evidence-based management across settings. To develop an evidence-based wound infection guideline, PubMed, Cochrane Library, and Cumulative Index to Nursing and Allied Health Literature databases were searched from inception through August 1, 2017 using the terms (or synonyms) wound infection and risk factor, significant, diagnosis, prevention, treatment, or surveillance...
November 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/29166249/qualitative-exploration-of-cross-sector-perspectives-on-the-contributions-of-local-health-departments-in-land-use-and-transportation-policy
#12
Meera Sreedhara, Karin Valentine Goins, Semra A Aytur, Rodney Lyn, Jay E Maddock, Robin Riessman, Thomas L Schmid, Heather Wooten, Stephenie C Lemon
INTRODUCTION: Transportation and land-use policies can affect the physical activity of populations. Local health departments (LHDs) are encouraged to participate in built-environment policy processes, which are outside their traditional expertise. Cross-sector collaborations are needed, yet stakeholders' perceptions of LHD involvement are not well understood. The objective of this study was to describe the perceived value of LHD participation in transportation and land-use decision making and potential contributions to these processes among stakeholders...
November 22, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29166084/on-the-electron-density-localization-in-elemental-cubic-ceramic-and-fcc-transition-metals-by-means-of-a-localized-electrons-detector
#13
Yosslen Aray, Ricardo Paredes, Luis Javier Álvarez, Alejandro Martiz
The electron density localization in insulator and semiconductor elemental cubic materials with diamond structure, carbon, silicon, germanium, and tin, and good metallic conductors with face centered cubic structure such as α-Co, Ni, Cu, Rh, Pd, Ag, Ir, Pt, and Au, was studied using a localized electrons detector defined in the local moment representation. Our results clearly show an opposite pattern of the electron density localization for the cubic ceramic and transition metal materials. It was found that, for the elemental ceramic materials, the zone of low electron localization is very small and is mainly localized on the atomic basin edges...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166010/conformational-dynamics-of-asparagine-at-coiled-coil-interfaces
#14
Franziska Thomas, Ai Niitsu, Alain Oregioni, Gail J Bartlett, Derek N Woolfson
Coiled coils (CCs) are among the best-understood protein folds. Nonetheless, there are gaps in our knowledge of CCs. Notably, CCs are likely to be structurally more dynamic than often considered. Here, we explore this in an abundant class of CCs, parallel dimers, focusing on polar asparagine (Asn) residues in the hydrophobic interface. It is well documented that such inclusions discriminate between different CC oligomers, which has been rationalized in terms of whether the Asn can make side-chain hydrogen bonds or not...
November 22, 2017: Biochemistry
https://www.readbyqxmd.com/read/29165990/uio-66-nh2-mof-nucleation-on-tio2-zno-and-al2o3-ald-treated-polymer-fibers-role-of-metal-oxide-on-mof-growth-and-catalytic-hydrolysis-of-chemical-warfare-agent-simulants
#15
Dennis T Lee, Junjie Zhao, Christopher J Oldham, Gregory W Peterson, Gregory N Parsons
Metal-organic frameworks (MOFs) chemically bound to polymeric microfibrous textiles show promising performance for many future applications. In particular, Zr-based UiO-66-family MOF-textiles have been shown to catalytically degrade highly toxic chemical warfare agents (CWAs), where favorable MOF/polymer bonding and adhesion are attained by placing a nanoscale metal-oxide layer on the polymer fiber preceding MOF growth. To date, however, the nucleation mechanism of Zr-based MOFs on different metal oxides and how product performance is affected are not well understood...
November 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29165989/bispentafluorophenyl-containing-additive-enhancing-efficiency-and-morphological-stability-of-polymer-solar-cells-via-hand-grabbing-like-supramolecular-pentafluorophenyl-fullerene-interactions
#16
Kai-En Hung, Che-En Tsai, Shao-Ling Chang, Yu-Ying Lai, U-Ser Jeng, Fong-Yi Cao, Chain-Shu Hsu, Chun-Jen Su, Yen-Ju Cheng
A new class of additive materials bis(pentafluorophenyl) diesters (BFEs) where the two pentafluorophenyl (C6F5) moieties are attached at the both ends of a linear aliphatic chain with tunable tether lengths (BF5, BF7, and BF13) were designed and synthesized. In the presence of the BF7 to restrict the migration of fullerene by hand-grabbing-like supramolecular interactions induced between the C6F5 groups and the surface of fullerene, the P3HT:PC61BM:BF7 device showed stable device characteristics after thermal heating at 150 oC for 25 h...
November 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29165983/incorporating-electrode-modification-layer-with-vertical-phase-separated-photoactive-layer-for-efficient-and-stable-inverted-nonfullerene-polymer-solar-cells
#17
Zhenzhen Shi, Hao Liu, Yaping Wang, Jinyan Li, Yiming Bai, Fuzhi Wang, Xingming Bian, Tasawar Hayat, Ahmed Alsaedi, Zhan'ao Tan
For bulk heterojunction polymer solar cells (PSCs), the donors and acceptors featuring specific phase separation and concentration distribution within the electron donor:acceptor blends crucially affect the exciton dissociation and charge transportation. Herein, efficient and stable nonfullerene inverted PSCs incorporating phase separated photoactive layer and titanium chelate electrode modification layer are demonstrated. Water contact angle (WCA), scanning kelvin probe microscopy (SKPM), and atomic force microscopy (AFM) techniques are implemented to characterize the morphology of photoactive layers...
November 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29165952/identifying-and-eliminating-the-barriers-to-patient-education-for-patients-in-the-early-stages-of-chronic-kidney-disease
#18
Sherry Rivera
Patients with chronic kidney disease (CKD) often do not have the knowledge they need to adequately manage their disease and prevent progression. Educating patients with the early stages of CKD is warranted and may assist in delaying progression of disease, improving outcomes, and reducing health expenditures. However, evidence is currently lacking regarding the best methods and approach to educating patients in the early stages of CKD. Multiple patient, provider, and system barriers can interfere with the delivery of patient education in the early stages of CKD...
May 2017: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29165934/first-rapid-assessment-of-avoidable-blindness-survey-in-the-maldives-prevalence-and-causes-of-blindness-and-cataract-surgery
#19
Ubeydulla Thoufeeq, Taraprasad Das, Hans Limburg, Maharshi Maitra, Lapam Panda, Asim Sil, John Trevelyan, Yuddha Sapkota
PURPOSE: A nationwide rapid assessment of avoidable blindness survey was undertaken in the Maldives among people aged 50 years or more to assess the prevalence and causes of blindness and visual impairment, cataract surgical coverage, cataract surgery outcome, and barriers to uptake of cataract surgical services. DESIGN: Prospective population-based study. METHODS: In the cluster sampling probability proportionate to size method, 3100 participants in 62 clusters across all 20 atolls were enrolled through house-to-house visits...
November 22, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29165847/breast-lesion-characterization-using-whole-lesion-histogram-analysis-with-stretched-exponential-diffusion-model
#20
Chunling Liu, Kun Wang, Xiaodan Li, Jine Zhang, Jie Ding, Karl Spuhler, Timothy Duong, Changhong Liang, Chuan Huang
BACKGROUND: Diffusion-weighted imaging (DWI) has been studied in breast imaging and can provide more information about diffusion, perfusion and other physiological interests than standard pulse sequences. The stretched-exponential model has previously been shown to be more reliable than conventional DWI techniques, but different diagnostic sensitivities were found from study to study. PURPOSE: This work investigated the characteristics of whole-lesion histogram parameters derived from the stretched-exponential diffusion model for benign and malignant breast lesions, compared them with conventional apparent diffusion coefficient (ADC), and further determined which histogram metrics can be best used to differentiate malignant from benign lesions...
November 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
keyword
keyword
40032
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"