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Paul Mätzig, Shravan Vasishth, Felix Engelmann, David Caplan, Frank Burchert
We present a computational evaluation of three hypotheses about sources of deficit in sentence comprehension in aphasia: slowed processing, intermittent deficiency, and resource reduction. The ACT-R based Lewis and Vasishth (2005) model is used to implement these three proposals. Slowed processing is implemented as slowed execution time of parse steps; intermittent deficiency as increased random noise in activation of elements in memory; and resource reduction as reduced spreading activation. As data, we considered subject vs...
January 22, 2018: Topics in Cognitive Science
Giuseppe Celenza, Mattia Vicario, Pierangelo Bellio, Linciano Pasquale, Mariagrazia Perilli, Antonio Oliver, Jesus Blazquez, Laura Cendron, Donatella Tondi
The emergence and dissemination of multi drug resistant (MDR) pathogens resistant to near all available antibiotics poses a significant threat in clinical therapy. Among them, Klebsiella pneumoniae clinical isolates overexpressing KPC-2 carbapenemase are the most worrisome, extending bacterial resistance to last resort carbapenems. In this study we investigate the molecular recognition requirements in KPC-2 active site by small phenyl boronic acid derivatives. Four new phenyl boronic acid derivatives were designed and tested vs KPC-2...
January 22, 2018: ChemMedChem
Hans C Fledelius, Nina Jacobsen, Xiao Q Li, Ernst Goldschmidt
BACKGROUND AND PURPOSE: A population-based Copenhagen birth year 1948 cohort with high myopia recorded since age 14 years (spherical equivalent less than or equivalent to -6 D) has been followed over 50 years. Despite complications, current follow-ups have outlined a better visual prognosis than usually drawn from selected clinical series in the literature. For the present status at age 66 years, focus was on visual ability and choroidal thickness. METHODS: Twenty-eight of the original 39 participants were available in 2014...
February 2018: Acta Ophthalmologica
Dan Bing, Jun Ying, Jun Miao, Lan Lan, Dayong Wang, Lidong Zhao, Zifang Yin, Lan Yu, Jing Guan, Qiuju Wang
OBJECTIVE: Sudden sensorineural hearing loss (SSHL) is a multifactorial disorder with high heterogeneity, thus the outcomes vary widely. The present study aimed to develop predictive models based on four machine learning methods for SSHL, identifying the best performer for clinical application. DESIGN: Single-center retrospective study. SETTING: Chinese People's liberation army (PLA) hospital, Beijing, China. PARTICIPANTS: 1220 in-patient SSHL patients were enrolled between June 2008 and December 2015...
January 21, 2018: Clinical Otolaryngology
Joane S Elleouet, Sally N Aitken
Approximate Bayesian computation (ABC) is widely used to infer demographic history of populations and species using DNA markers. Genomic markers can now be developed for non-model species using reduced representation library (RRL) sequencing methods that select a fraction of the genome using targeted sequence capture or restriction enzymes (genotyping-by-sequencing, GBS). We explored the influence of marker number and length, knowledge of gametic phase, and tradeoffs between sample size and sequencing depth on the quality of demographic inferences performed with ABC...
January 22, 2018: Molecular Ecology Resources
Boyang Chang, Lujun Shen, Kefeng Wang, Jietian Jin, Tao Huang, Qifeng Chen, Wang Li, Peihong Wu
BACKGROUND & AIMS: Adjuvant cytokine-induced killer (CIK) cells treatment has shown potential in reducing the recurrence rate and prolonging the survival of patients with hepatocellular carcinoma (HCC). We aimed to identify the best predictive biomarker for adjuvant CIK cells treatment in patients with HCC after curative resection. METHODS: This study retrospectively included 145 pairs of HCC patients by one-to-one propensity score matching. One group received CIK cells transfusion after surgery (Surgery-CIK group); the other one group underwent surgery only (Surgery-only group)...
January 22, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Abigail Ortiz, Kamil Bradler, Arend Hintze
OBJECTIVE: Bipolar disorder is a severe mood disorder characterized by alternating episodes of mania and depression. Several interventions have been developed to decrease high admission rates and high suicides rates associated with the illness, including psychoeducation and early episode detection, with mixed results. More recently, machine learning approaches have been used to aid clinical diagnosis or to detect a particular clinical state; however, contradictory results arise from confusion around which of the several automatically generated data are the most contributory and useful to detect a particular clinical state...
January 22, 2018: Bipolar Disorders
Andrea Corsonello, Claudio Pedone, Stefania Bandinelli, Luigi Ferrucci, Raffaele Antonelli Incalzi
AIMS: There is uncertainty about which estimated glomerular filtration rate eGFR equation to use in older people with respect to the prediction of prognosis. Our aim was: (i) to compare the discriminative capacity of eGFR estimated by different equations with respect to all-cause mortality; and (ii) to identify the eGFR threshold at which the risk of mortality starts to increase for each equation. METHODS: We used data from 828 community-dwelling older adults aged >65 years enrolled in the InCHIANTI study...
January 22, 2018: Geriatrics & Gerontology International
Yong Feng, Jie Feng, Qinglong Shu
AIMS: We sought to isolate novel heterotrophic nitrifying and aerobic denitrifying Klebsiella pneumoniae (K. pneumoniae) and Klebsiella variicola (K. variicola) strains from various natural environments and characterize their nitrogen removal processes. METHODS AND RESULTS: Ten novel Klebsiella strains with heterotrophic nitrification and aerobic denitrification abilities, including seven K. pneumoniae and three K. variicola, were successfully isolated from feces, sewage, plant surfaces and sludge...
January 21, 2018: Journal of Applied Microbiology
Suzanne M Willey, Robyn P Cant, Allison Williams, Meredith McIntyre
AIMS AND OBJECTIVES: This study aimed to explore service provision for Victorian regional refugee families from the perspective of Maternal and Child Health nurses. BACKGROUND: Increasingly, more families from a refugee background are resettling in regional Victoria. The refugee journey has significant effect on families. Refugee families with infants and young children can be provided with support by Maternal and Child Health services; however, many families experience barriers to ongoing engagement with this service...
January 21, 2018: Journal of Clinical Nursing
Ke Meng, Longlong Wu, Zhou Liu, Xiao Wang, Qiaofei Xu, Youdi Hu, Sanfeng He, Xiaolong Li, Tao Li, Gang Chen
Metal halide perovskite solar cells (PSCs) have advanced to the forefront of solution-processed photovoltaic techniques and made stunning progress in power conversion efficiency (PCE). Further improvements in device performances rely on perfecting the structure and morphology of perovskite films. However, undesirable defects such as pinholes and grain boundaries are often created in film preparations due to lack of knowledge of the precise reaction mechanism. Here, in situ grazing-incidence X-ray diffraction (GI-XRD) investigations are performed, facilitated by other techniques, on the formation of the widely adopted MAPbI3 (MA = methylammonium) perovskite films from their intermediate adduct (IA) phases...
January 22, 2018: Advanced Materials
Alexander Leube, Caroline Kraft, Arne Ohlendorf, Siegfried Wahl
BACKGROUND: This explorative study investigated procedures for the self-assessment of spherocylindrical refractive errors. METHODS: Eighteen participants with a mean age of 34.0 ± 8.8 years were enrolled. Adjustable Alvarez lenses were mounted in a rotatable ring holder and two procedures were tested for the self-adjustment: (1) rotation of the lens in three meridians: 0°, 60° and 120° and (2) rotation of the optotypes in the same meridians. Starting from maximum positive power, the participants were required to decrease the power of the Alvarez lens until the optotypes (0...
January 21, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
E E L Lewis, M R T Barrett, L Freeman-Parry, R A Bojar, M R Clench
OBJECTIVE: Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) to identify lipids directly involved as potential biomarkers. These biomarkers may be used to determine whether an in vivo wound is going to heal for example if infected. METHODS: An in vitro LSE model was wounded with a scalpel blade and assessed at day 4 post wounding by histology and MALDI-MSI...
January 21, 2018: International Journal of Cosmetic Science
Ioannis T Konstantinidis, Carolijn Nota, Zeljka Jutric, Philip Ituarte, Warren Chow, Peiguo Chu, Gagandeep Singh, Susanne G Warner, Laleh G Melstrom, Yuman Fong
BACKGROUND AND OBJECTIVES: Primary liver sarcomas (PLS) are rare. Published series are limited by small numbers of patients. METHODS: We reviewed the National Cancer Database (2004-2014) for patients who underwent surgical resection of PLS. RESULTS: Of 237 patients identified, the majority were female (60.8%), with median age of 52 years. Histologies were: epithelioid hemangioendothelioma (n = 67), angiosarcoma (n = 64), leiomyosarcoma (n = 33), embryonal rhabdomyosarcoma (n = 31), carcinosarcoma (n = 16), giant cell sarcoma (n = 14), spindle cell sarcoma (n = 12)...
January 22, 2018: Journal of Surgical Oncology
Barbara Buchberger, Laura Krabbe
BACKGROUND: Acupuncture is a non-pharmacological option to relieve pregnancy-related complaints. OBJECTIVES: To critically appraise the best available evidence for the use of acupuncture in outpatient care. SEARCH STRATEGY: The MEDLINE, Cochrane Library, and Centre for Reviews and Dissemination databases were searched for English-language and German-language papers published from January 1980 to March 2017 using search terms related to pregnancy combined with 'acupuncture'...
January 21, 2018: International Journal of Gynaecology and Obstetrics
Liza Behrens, Kimberly Van Haitsma, Jennifer Brush, Marie Boltz, Donna Volpe, Ann Marie Kolanowksi
Delivering person-centered care (PCC) is no longer an option for nursing homes (NH) that receive funding from the Centers for Medicare & Medicaid Services. NH staff need evidence-based protocols to guide efforts in honoring preferred choices of residents, especially those that are perceived to be risky. The Rothschild Care Planning Process for Resident Choice was created to honor such choices. The current article provides a case exemplar to demonstrate the use of the Rothschild Care Planning Process for Resident Choice with one NH resident who was perceived by staff to be making a risky choice...
January 16, 2018: Journal of Gerontological Nursing
Kamil Kosiel, Magdalena Dominik, Iga Ściślewska, Małgorzata Kalisz, Marek Guziewicz, Krystyna Gołaszewska, Joanna Niedziółka-Jonsson, Wojtek J Bock, Mateusz J Smietana
The paper presents investigation of properties of selected metallic oxides deposited at low temperature (100°C) by atomic layer deposition (ALD) technique, relating to their applicability as thin overlays for optical fiber sensors resistant in alkaline environments. Hafnium oxide (Hf<sub>x</sub>O<sub>y</sub> with y/x approx. 2.70), tantalum oxide (Ta<sub>x</sub>O<sub>y</sub> with y/x approx. 2.75) and zirconium oxide (Zr<sub>x</sub>O<sub>y</sub> with y/x approx...
January 22, 2018: Nanotechnology
Anna Wilsch, Toralf Neuling, Jonas Obleser, Christoph S Herrmann
Cortical entrainment of the auditory cortex to the broadband temporal envelope of a speech signal is crucial for speech comprehension. Entrainment results in phases of high and low neural excitability, which structure and decode the incoming speech signal. Entrainment to speech is strongest in the theta frequency range (4-8 Hz), the average frequency of the speech envelope. If a speech signal is degraded, entrainment to the speech envelope is weaker and speech intelligibility declines. Besides perceptually evoked cortical entrainment, transcranial alternating current stimulation (tACS) entrains neural oscillations by applying an electric signal to the brain...
January 17, 2018: NeuroImage
Scott R Solomon, Michael A Aubrey, Xu Zhang, Allison Piluso, Brian M Freed, Stacey Brown, Katelin C Jackson, Lawrence E Morris, H Kent Holland, Melhem M Solh, Asad Bashey
The use of post-transplant cyclophosphamide (PTCy)-based haploidentical (haplo) transplant is increasing worldwide. However, as multiple potential haplo donors are usually available, data-driven guidance is clearly needed to help transplant centers prioritize donors. To that end, we retrospectively analyzed 208 consecutive donor-recipient pairs receiving PTCy-based haplo transplant at a single institution. Median recipient and donor age was 52 (19-75) and 38 (15-73) years, PBSC was the stem cell source in 66%, and myeloablative conditioning was used in 41%...
January 17, 2018: Biology of Blood and Marrow Transplantation
Lijun Li, Hui Liao, Yan Yang, Jianye Gong, Jianan Liu, Zedong Jiang, Yanbing Zhu, Anfeng Xiao, Hui Ni
To improve the thermostability of α-L-rhamnosidase (r-Rha1), an enzyme previously identified from Aspergillus niger JMU-TS528, multiple arginine (Arg) residues were introduced into the r-Rha1 sequence to replace several lysine (Lys) residues that located on the surface of the folded r-Rha1. Hinted by in silico analysis, five surface Lys residues (K134, K228, K406, K440, K573) were targeted to produce a list of 5 single-residue mutants and 4 multiple-residue mutants using site-directed mutagenesis. Among these mutants, a double Lys to Arg mutant, i...
January 17, 2018: International Journal of Biological Macromolecules
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