keyword
https://read.qxmd.com/read/38536562/exome-sequencing-identified-mutations-in-the-wnt1-and-col1a2-genes-in-osteogenesis-imperfecta-cases
#1
JOURNAL ARTICLE
Poonam Mehta, Rahul Vishvkarma, Sushil Gupta, Naibedya Chattopadhyay, Singh Rajender
BACKGROUND: Osteogenesis imperfecta (OI) is a heritable connective tissue disorder characterized by bone deformities, fractures and reduced bone mass. OI can be inherited as a dominant, recessive, or X-linked disorder. The mutational spectrum has shown that autosomal dominant mutations in the type I collagen-encoding genes are responsible for OI in 85% of the cases. Apart from collagen genes, mutations in more than 20 other genes, such as CRTAP, CREB3L1, MBTPS2, P4HB, SEC24D, SPARC, FKBP10, LEPRE1, PLOD2, PPIB, SERPINF1, SERPINH1, SP7, WNT1, BMP1, TMEM38B, and IFITM5 have been reported in OI...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38534764/bioconversion-pharmacokinetics-and-therapeutic-mechanisms-of-ginsenoside-compound-k-and-its-analogues-for-treating-metabolic-diseases
#2
REVIEW
Md Niaj Morshed, Reshmi Akter, Md Rezaul Karim, Safia Iqbal, Se Chan Kang, Deok Chun Yang
Rare ginsenoside compound K (CK) is an intestinal microbial metabolite with a low natural abundance that is primarily produced by physicochemical processing, side chain modification, or metabolic transformation in the gut. Moreover, CK exhibits potent biological activity compared to primary ginsenosides, which has raised concerns in the field of ginseng research and development, as well as ginsenoside-related dietary supplements and natural products. Ginsenosides Rb1, Rb2, and Rc are generally used as a substrate to generate CK via several bioconversion processes...
March 11, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534361/brain-derived-neurotrophic-factor-bdnf-enhances-osteogenesis-and-may-improve-bone-microarchitecture-in-an-ovariectomized-rat-model
#3
JOURNAL ARTICLE
Eugene J Park, Van-Long Truong, Woo-Sik Jeong, Woo-Kie Min
BACKGROUND: Brain-derived neurotrophic factor (BDNF) has gained attention as a therapeutic agent due to its potential biological activities, including osteogenesis. However, the molecular mechanisms involved in the osteogenic activity of BDNF have not been fully understood. This study aimed to investigate the action of BDNF on the osteoblast differentiation in bone marrow stromal cells, and its influence on signaling pathways. In addition, to evaluate the clinical efficacy, an in vivo animal study was performed...
March 15, 2024: Cells
https://read.qxmd.com/read/38534275/biological-effects-of-orthodontic-tooth-movement-on-the-periodontium-in-regenerated-bone-defects-a-scoping-review
#4
REVIEW
Alessio Verdecchia, Carlota Suárez-Fernández, Andrea Miquel, Giulia Bardini, Enrico Spinas
The aim of this scoping review is to analyse the biological effects of the orthodontic tooth movement (OTM) in areas with bone defects that are undergoing regeneration using different types of regenerative materials and techniques. The electronic research was performed on four databases as follows: PubMed, Scopus, EMBASE, and Web of Science. Data were extracted according to publication information, study design, sample characteristics, parameters of OTM, biological repercussions on the periodontium complex, methods of analysis, and conclusions...
February 26, 2024: Dentistry Journal
https://read.qxmd.com/read/38534217/development-of-aav-mediated-gene-therapy-approaches-to-treat-skeletal-diseases
#5
JOURNAL ARTICLE
Chujiao Lin, Matthew Greenblatt, Guangping Gao, Jae-Hyuck Shim
Adeno-associated viral (AAV) vectors have emerged as crucial tools in advancing gene therapy for skeletal diseases, offering the potential for sustained expression with low post-infection immunogenicity and pathogenicity. Preclinical studies support both the therapeutic efficacy and safety of these vectors, illustrating the promise of AAV-mediated gene therapy. Emerging technologies and innovations in AAV-mediated gene therapy strategies, such as gene addition, gene replacement, gene silencing, and gene editing, offer new approaches to clinical application...
March 27, 2024: Human Gene Therapy
https://read.qxmd.com/read/38533625/aspirin-loaded-anti-inflammatory-zno-sio-2-aerogel-scaffolds-for-bone-regeneration
#6
JOURNAL ARTICLE
Yue Zhao, Caiqi Cheng, Xinyi Wang, Zhengchao Yuan, Binbin Sun, Mohamed El-Newehy, Meera Moydeen Abdulhameed, Bing Fang, Xiumei Mo
The increasing aging of the population has elevated bone defects to a significant threat to human life and health. Aerogel, a biomimetic material similar to an extracellular matrix (ECM), is considered an effective material for the treatment of bone defects. However, most aerogel scaffolds suffer from immune rejection and poor anti-inflammatory properties and are not well suited for human bone growth. In this study, we used electrospinning to prepare flexible ZnO-SiO2 nanofibers with different zinc concentrations and further assembled them into three-dimensional composite aerogel scaffolds...
March 27, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38531790/mechanical-stretch-induced-atp-release-from-osteocytes-promotes-osteogenesis-of-bone-marrow-mesenchymal-stem-cells
#7
JOURNAL ARTICLE
Yiwen Ru, Hong Gu, Lian Sun, WeiBing Zhang, Lin Wang
BACKGROUND: Mandibular distraction osteogenesis (MDO) is a highly effective method for bone regeneration, commonly employed in treating craniofacial defects and deformities. Osteocytes sense mechanical forces in the pericellular space, relay external stimuli to biochemical changes, and send signals to other effector cells, including bone marrow mesenchymal stem cells (BM-MSCs), to regulate bone resorption and formation. Piezo1 potentially affects the secretion signal molecules of bone cells under mechanical stretch...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38530974/conductive-and-enhanced-mechanical-strength-of-mo-2-ti-2-c-3-mxene-based-hydrogel-promotes-neurogenesis-and-bone-regeneration-in-bone-defect-repair
#8
JOURNAL ARTICLE
Hongyu Wang, Yu-Ching Hsu, Chune Wang, Xiao Xiao, Zhengbin Yuan, Yong Zhu, Dazhi Yang
Bone defects are common with increasing high-energy fractures, tumor bone invasion, and implantation revision surgery. Bone is an electroactive tissue that has electromechanical interaction with collogen, osteoblasts, and osteoclasts. Hydrogel provides morphological plasticity and extracellular matrix (ECM) 3D structures for cell survival, and is widely used as a bone engineering material. However, the hydrogels have poor mechanical intensity and lack of cell adhesion, slow gelation time, and limited conductivity...
March 26, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38530906/%C3%A2-leveraging%C3%A2-selective-knockdown-of-sost-gene-by%C3%A2-polyethyleneimine-sirna-chitosan-reduced-gold%C3%A2-nanoparticles-to%C3%A2-promote-osteogenesis-in-mc3t3-e1-mef-cells
#9
JOURNAL ARTICLE
Karishma Niveria, Mohammad ZafarYab, Largee Biswas, Asiya Mahtab, Anita Kamra Verma
Aim: Osteoporosis is a systemic skeletal disorder characterized by reduced osteoblast differentiation, predominantly by overexpression of the Sost gene. A layer-by-layer approach enabled encapsulation of Sost siRNA to enhance the short half-life and poor transfection capacity of siRNA. Materials & methods: Polyethyleneimine and siRNA on chitosan-coated gold nanoparticles (PEI/siRNA/Cs-AuNPs) were engineered using chitosan-reduced gold nanoparticles. They were characterized by dynamic light scattering, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared and gel-mobility assays...
March 26, 2024: Nanomedicine
https://read.qxmd.com/read/38529844/a-whole-course-repair-system-based-on-ros-glucose-stimuli-responsive-egcg-release-and-tunable-mechanical-property-for-efficient-treatment-of-chronic-periodontitis-in-diabetic-rats
#10
JOURNAL ARTICLE
Qingchen Feng, Mei Zhang, Guanning Zhang, Hongxiang Mei, Chongying Su, Lisa Liu, Xiaoxia Wang, Ziqianhong Wan, Zhengyi Xu, Liangkui Hu, Yu Nie, Juan Li
Elevated glucose levels, multiple pro-inflammatory cytokines and the generation of excessive reactive oxygen species (ROS) are pivotal characteristics within the microenvironments of chronic periodontitis with diabetes mellitus (CPDM). Control of inflammation and modulation of immune system are required in the initial phase of CPDM treatment, while late severe periodontitis requires a suitable scaffold to promote osteogenesis, rebuild periodontal tissue and reduce alveolar bone resorption. Herein, a whole-course-repair system is introduced by an injectable hydrogel using phenylboronic acid functionalized oxidized sodium alginate (OSA-PBA) and carboxymethyl chitosan (CMC)...
March 26, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38529842/emulsion-template-fabricated-heterogeneous-bilayer-gelatin-based-scaffolds-with-sustained-delivery-of-lycium-barbarum-glycopeptide-for-periodontitis-treatment
#11
JOURNAL ARTICLE
Siqi He, Nan Wen, Xun Chen, Cong Liu, Xun Xiao, Xinlun Li, Lun Yuan, Yandong Mu
Periodontitis is a chronic inflammatory disease raising the risks of tooth-supporting structures destruction and even tooth loss. The way to reconstruct periodontal bone tissues in inflammatory microenvironment has been long in demand for periodontitis treatment. In this study, the lycium barbarum glycopeptide (LbGP) loaded gelatin-based scaffolds were fabricated for periodontitis treatment. Gelatin microspheres with suitable size were prepared by emulsification and gathered by oxidized sodium alginate to prepare heterogeneous bilayer gelatin-based scaffolds, and then they were loaded with LbGP...
March 26, 2024: Journal of Biomaterials Science. Polymer Edition
https://read.qxmd.com/read/38529833/an-injectable-magnesium-based-cement-stimulated-with-nir-for-drug-controlled-release-and-osteogenic-potential
#12
JOURNAL ARTICLE
Yanbin Zhao, Yangyang Li, Bin Wang, Junyan Yao, Yue Fan, Peng He, Jing Bai, Cheng Wang, Feng Xue, Chenglin Chu
Magnesium phosphate bone cement (MPC) has gained widespread usage in orthopedic implantation due to its fast-setting and high initial strength benefits. However, the simultaneous attainment of drug-controlled release and osteogenic potential in MPC remains a significant challenge. Herein, we proposed a strategy to create a smart injectable cement system using nanocontainers and chondroitin sulfate. It employed nanocontainers containing alendronate-loaded mesoporous silica nanoparticles, which had been surface-modified with polypyrrole to control drug release in response to near infrared (NIR) stimulation...
March 26, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38527620/rapamycin-facilitates-the-tendon-bone-interface-healing-in-an-aging-rat-model-of-chronic-rotator-cuff-injury
#13
JOURNAL ARTICLE
Xinwang Zhi, Haolin Ke, Li Zhou, Jintao Li, Panjing Yin, Haiyan Zhang, Chun Zeng, Daozhang Cai, Huabin Chen
BACKGROUND: Tendon-bone interface (TBI) healing in chronic rotator cuff injury (CRCI) in older individuals is a common clinical challenge due to cellular senescence, as well as decreased tissue repair and regeneration. Many studies have demonstrated the anti-aging, improved tissue repair, and bone regeneration properties of rapamycin (RPM) in multiple age-related diseases. This study aimed to explore the effects of RPM on TBI healing after CRCI in an aging rat model. METHODS: A CRCI model was established in 60 Sprague-Dawley rats (24 months old)...
March 23, 2024: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/38527040/indirect-co-culture-of-osteoblasts-and-endothelial-cells-in-vitro-based-on-a-biomimetic-3d-composite-hydrogel-scaffold-to-promote-the-proliferation-and-differentiation-of-osteoblasts
#14
JOURNAL ARTICLE
Cheng Li, Guanghui Chen, Yangyang Wang, Wenwu Xu, Minghui Hu
The field of orthopedics has long struggled with the challenge of repairing and regenerating bone defects, which involves a complex process of osteogenesis requiring coordinated interactions among different types of cells. The crucial role of endothelial cells and osteoblasts in bone vascularization and osteogenesis underscores the importance of their intimate interaction. However, efforts to bioengineer bone tissue have been impeded by the difficulty in establishing proper angiogenesis and osteogenesis in tissue structures...
2024: PloS One
https://read.qxmd.com/read/38526702/osteopontin-promotes-tumor-growth-and-metastasis-and-gpx4-mediated-anti-lipid-peroxidation-in-triple-negative-breast-cancer-by-activating-the-pi3k-akt-mtor-pathway
#15
JOURNAL ARTICLE
Man Guo, Mengyue Liu, Weihan Li, Cao Wang, Lu Zhang, Hao Zhang
PURPOSE: Triple-negative breast cancer (TNBC) features high aggressiveness, metastasis rate, drug resistance as well as poor prognosis. Osteopontin (OPN) is a key protein in the process of osteogenesis and has emerged as a new tumor marker in recent years. METHODS: Cell viability was tested with the CCK-8 kit. Transwell and wound healing were adopted to test cell invasive and migratory abilities. Tumor sphere formation was detected by tumor sphere formation assay...
March 25, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38526212/relative-contributions-of-osteal-macrophages-and-osteoclasts-to-postnatal-bone-development-in-csf1r-deficient-rats-and-phenotype-rescue-following-wild-type-bone-marrow-cell-transfer
#16
JOURNAL ARTICLE
Lena Batoon, Sahar Keshvari, Katharine M Irvine, Eileen Ho, Melanie Caruso, Omkar L Patkar, Anuj Sehgal, Susan M Millard, David A Hume, Allison R Pettit
Macrophage and osteoclast proliferation, differentiation and survival are regulated by colony-stimulating factor-1 receptor (CSF1R) signaling. Osteopetrosis associated with Csf1 and Csf1r mutations has been attributed to the loss of osteoclasts and deficiency in bone resorption. Here we demonstrate that homozygous Csf1r mutation in rat leads to delayed postnatal skeletal ossification associated with substantial loss of osteal macrophages (osteomacs) in addition to osteoclasts. Osteosclerosis and site-specific skeletal abnormalities were reversed by intraperitoneal transfer of wild-type bone marrow cells (BMT) at weaning...
March 25, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38525453/z-osteotomy-for-uniplanar-femoral-shaft-deformity-correction-in-an-adolescent-with-osteogenesis-imperfecta
#17
Faris Indra Prahasta Bin Didi Indra, Anuar Ramdhan Bin Ibrahim, Mohamad Zaki Bin Mohd Amin
Osteogenesis imperfecta (OI) is commonly associated with fragility fractures. It is due to abnormality in the quantity and quality of collagen type 1 caused by mutations in COL1A1 and COL1A2 genes. Patients with OI would also have blue sclera, ligament hyperlaxity, dentinogenesis imperfecta, hearing abnormality, and short stature. Surgical management is preferred to conservative treatment in long bone fractures. For malunited fractures, Sofield-Millar or multiple osteotomies at different sites of deformities are performed with additional intramedullary device to stabilize the bone...
2024: Medical Journal, Armed Forces India
https://read.qxmd.com/read/38525312/stepwise-degradable-pga-sf-core-shell-electrospinning-scaffold-with-superior-tenacity-in-wetting-regime-for-promoting-bone-regeneration
#18
JOURNAL ARTICLE
Yuan Zhang, Yutao Jian, Xiao Jiang, Xuerong Li, Xiangnan Wu, Juan Zhong, Xiaoshi Jia, Qiulan Li, Xiaodong Wang, Ke Zhao, Yitong Yao
Regenerating bone in the oral and maxillofacial region is clinically challenging due to the complicated osteogenic environment and the limitation of existing bone graft materials. Constructing bone graft materials with controlled degradation and stable mechanical properties in a physiological environment is of utmost importance. In this study, we used silk fibroin (SF) and polyglycolic acid (PGA) to fabricate a coaxial PGA-SF fibrous scaffold (PGA-SF-FS) to meet demands for bone grafts. The SF shell exerted excellent osteogenic activity while protecting PGA from rapid degradation and the PGA core equipped scaffold with excellent tenacity...
June 2024: Materials today. Bio
https://read.qxmd.com/read/38525199/in-vivo-imaging-of-bone-collagen-dynamics-in-zebrafish
#19
JOURNAL ARTICLE
Hiromu Hino, Shigeru Kondo, Junpei Kuroda
Type I collagen plays a pivotal role in shaping bone morphology and determining its physical properties by serving as a template for ossification. Nevertheless, the mechanisms underlying bone collagen formation, particularly the principles governing its orientation, remain unknown owing to the lack of a method that enables continuous in vivo observations. To address this challenge, we constructed a method to visualize bone collagen by tagging with green fluorescent protein (GFP) in zebrafish and observed the interactions between osteoblasts and collagen fibers during bone formation in vivo...
March 2024: Bone Reports
https://read.qxmd.com/read/38525010/electrospun-l-lysine-amorphous-calcium-phosphate-loaded-core-sheath-nanofibers-for-managing-oral-biofilm-infections-and-promoting-periodontal-tissue-repairment
#20
JOURNAL ARTICLE
Yufeng Ling, Menglu Duan, Wen Lyu, Jie Yang, Yu Liu, Shuangshuang Ren, Wenlei Wu
INTRODUCTION: Periodontitis, a chronic inflammatory disease prevalent worldwide, is primarily treated through GTR for tissue regeneration. The efficacy of GTR, however, remains uncertain due to potential infections and the intricate microenvironment of periodontal tissue. Herein, We developed a novel core-shell structure multifunctional membrane using a dual-drug-loaded coaxial electrospinning technique (Lys/ACP-CNF), contains L-lysine in the outer layer to aid in controlling biofilms after GTR regenerative surgery, and ACP in the inner layer to enhance osteogenic performance for accelerating alveolar bone repair...
2024: International Journal of Nanomedicine
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