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Osteogenesis

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https://www.readbyqxmd.com/read/28806146/three-dimensional-bioprinting-of-polycaprolactone-reinforced-gene-activated-bioinks-for-bone-tissue-engineering
#1
Gráinne M Cunniffe, Tomas Gonzalez-Fernandez, Andrew Daly, Binulal N Sathy, Oju Jeon, Eben Alsberg, Daniel J Kelly
Regeneration of complex bone defects remains a significant clinical challenge. Multi-tool biofabrication has permitted the combination of various biomaterials to create multifaceted composites with tailorable mechanical properties and spatially controlled biological function. In this study we sought to use bioprinting to engineer nonviral gene activated constructs reinforced by polymeric micro-filaments. A gene activated bioink was developed using RGD-γ-irradiated alginate and nano-hydroxyapatite (nHA) complexed to plasmid DNA (pDNA)...
August 14, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28805807/notch-signaling-pathway-and-gene-expression-profiles-during-early-in-vitro-differentiation-of-liver-derived-mesenchymal-stromal-cells-to-osteoblasts
#2
Ksymena Urbanek, Marta Lesiak, Daniel Krakowian, Halina Koryciak-Komarska, Wirginia Likus, Piotr Czekaj, Damian Kusz, Aleksander L Sieroń
Notch signaling is a key signaling pathway for cell proliferation and differentiation. Therefore, we formulated a working hypothesis that Notch signaling can be used to detect early osteoblastic differentiation of mesenchymal stromal cells. Changes in expression and distribution of Notch 1, 2, 3, and Delta1 in the cytoplasm and nuclei of rat liver-derived mesenchymal stromal cells differentiating into osteoblasts were investigated, together with the displacement of intracellular domains (ICDs) of the receptors...
August 14, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28805275/participation-of-extracellular-signal-regulated-kinases-1-2-in-osteoblast-and-adipocyte-differentiation-of-mesenchymal-stem-cells-grown-on-titanium-surfaces
#3
Heitor F Silva, Rodrigo P F Abuna, Helena B Lopes, Marcelo S Francischini, Paulo T de Oliveira, Adalberto L Rosa, Marcio M Beloti
Osteoblasts and adipocytes coexist in the implantation site and affect the process of titanium (Ti) osseointegration. As extracellular signal-regulated kinases 1/2 (ERK1/2) are involved in osteogenesis and adipogenesis, the aim of our study was to investigate if the effects of Ti surface topography on osteoblast and adipocyte differentiation are modulated by ERK1/2. The experiments were conducted based on the effect of the ERK1/2 inhibitor, PD98059, on mesenchymal stem cells (MSCs) grown under osteogenic and adipogenic conditions on Ti with nanotopography (Ti-Nano) or on machined Ti (Ti-Machined)...
August 14, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/28804610/naringin-enhances-osteogenic-differentiation-through-the-activation-of-erk-signaling-in-human-bone-marrow-mesenchymal-stem-cells
#4
Huichao Wang, Chunbo Li, Jianming Li, Yingjie Zhu, Yudong Jia, Ying Zhang, Xiaodong Zhang, Wenlong Li, Lei Cui, Wuyin Li, Youwen Liu
OBJECTIVES: Naringin has been reported to regulate bone metabolism. However, its effect on osteogenesis remains unclear. The aim was to investigate the effect of naringin on osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) through the activation of the ERK signaling pathway in osteogenic differentiation. MATERIALS AND METHODS: Annexin V-FITC assay and MTT assay were used to measure the effect of naringin on cytotoxicity and proliferation of hBMSCs, respectively...
April 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28803739/two-stage-reconstruction-of-the-severely-deficient-alveolar-ridge-bone-graft-followed-by-alveolar-distraction-osteogenesis
#5
A Rachmiel, O Emodi, D Aizenbud, D Rachmiel, D Shilo
Distraction osteogenesis for the augmentation of severe alveolar bone deficiency has gained popularity during the past two decades. In cases where the vertical bone height is not sufficient to create a stable transport segment, performing alveolar distraction osteogenesis (ADO) is not possible. In these severe cases, a two-stage treatment protocol is suggested: onlay bone grafting followed by ADO. An iliac crest onlay bone graft followed by ADO was performed in 13 patients: seven in the mandible and six in the maxilla...
August 10, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28803411/electro-chemical-deposition-of-nano-hydroxyapatite-zinc-coating-on-titanium-metal-substrate
#6
N A El-Wassefy, F M Reicha, N S Aref
BACKGROUND: Titanium is an inert metal that does not induce osteogenesis and has no antibacterial properties; it is proposed that hydroxyapatite coating can enhance its bioactivity, while zinc can contribute to antibacterial properties and improve osseointegration. AIMS: A nano-sized hydroxyapatite-zinc coating was deposited on commercially pure titanium using an electro-chemical process, in order to increase its surface roughness and enhance adhesion properties...
August 13, 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28803246/biofunctional-ionic-doped-calcium-phosphates-silk-fibroin-composites-for-bone-tissue-engineering-scaffolding
#7
S Pina, R F Canadas, G Jiménez, M Perán, J A Marchal, R L Reis, J M Oliveira
The treatment and regeneration of bone defects caused by traumatism or diseases have not been completely addressed by current therapies. Lately, advanced tools and technologies have been successfully developed for bone tissue regeneration. Functional scaffolding materials such as biopolymers and bioresorbable fillers have gained particular attention, owing to their ability to promote cell adhesion, proliferation, and extracellular matrix production, which promote new bone growth. Here, we present novel biofunctional scaffolds for bone regeneration composed of silk fibroin (SF) and β-tricalcium phosphate (β-TCP) and incorporating Sr, Zn, and Mn, which were successfully developed using salt-leaching followed by a freeze-drying technique...
August 12, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28802681/activated-fgfr3-promotes-bone-formation-via-accelerating-endochondral-ossification-in-mouse-model-of-distraction-osteogenesis
#8
Yusuke Osawa, Masaki Matsushita, Sachi Hasegawa, Ryusaku Esaki, Masahito Fujio, Bisei Ohgawara, Naoki Ishiguro, Kinji Ohno, Hiroshi Kitoh
Achondroplasia (ACH) is one of the most common short-limbed skeletal dysplasias caused by gain-of-function mutations in the fibroblast growth factor receptors 3 (FGFR3) gene. Distraction osteogenesis (DO) is a treatment option for short stature in ACH in some countries. Although the patients with ACH usually show faster healing in DO, details of the newly formed bone have not been examined. We have developed a mouse model of DO and analyzed new bone regenerates of the transgenic mice with ACH (Fgfr3(ach) mice) histologically and morphologically...
August 9, 2017: Bone
https://www.readbyqxmd.com/read/28802583/cytoskeleton-and-nuclear-lamina-affection-in-recessive-osteogenesis-imperfecta-a-functional-proteomics-perspective
#9
Assunta Gagliardi, Roberta Besio, Chiara Carnemolla, Claudia Landi, Alessandro Armini, Mona Aglan, Ghada Otaify, Samia A Temtamy, Antonella Forlino, Luca Bini, Laura Bianchi
Osteogenesis imperfecta (OI) is a collagen-related disorder associated to dominant, recessive or X-linked transmission, mainly caused by mutations in type I collagen genes or in genes involved in type I collagen metabolism. Among the recessive forms, OI types VII, VIII, and IX are due to mutations in CRTAP, P3H1, and PPIB genes, respectively. They code for the three components of the endoplasmic reticulum complex that catalyzes 3-hydroxylation of type I collagen α1Pro986. Under-hydroxylation of this residue leads to collagen structural abnormalities and results in moderate to lethal OI phenotype, despite the exact molecular mechanisms are still not completely clear...
August 9, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28800464/accelerated-biomineralization-of-graphene-oxide-incorporated-cellulose-acetate-nanofibrous-scaffolds-for-mesenchymal-stem-cell-osteogenesis
#10
Xiaoyun Liu, He Shen, Saijie Song, Wei Chen, Zhijun Zhang
For bone tissue engineering, it requires that the scaffolds have excellent biocompatibility, proper mechanical and osteoinductive properties. Electrospun nanofibers with extracellular matrices mimicking structure have proven to be good scaffolds for bone tissue repairing. Hybrid nanofibers in particular, endow the nanofibers with specific and multiple functionalities, and therefore have attracted increasing interests in the recent years. In this study, we fabricated graphene oxide (GO)-incorporated cellulose acetate (CA) nanofibrous scaffolds by electrospinning technique for enhancement of biomineralization and osteogenic differentiation of human mesenchymal stem cells (hMSCs)...
July 29, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28799995/fassier-duval-telescopic-system-how-i-do-it
#11
Francois Fassier
The author describes step-by-step the technique for Fassier-Duval rodding of both femurs and tibiae in osteogenesis imperfecta. Preoperative evaluations and planning, postoperative care and place of bisphosphonates as explained. Emphasis is given on the different tricks to avoid intraoperative problems.
September 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28799987/a-brief-history-of-limb-lengthening
#12
John G Birch
In the last 35 years, orthopaedic surgeons have witnessed 3 major advances in the technique of limb lengthening: "distraction osteogenesis" facilitated by Gavriil Ilizarov method and infinitely-adaptable circular fixator with fine-wire bone fragment fixation; the introduction of the "6-strut" computer program-assisted circular fixators to effect complex deformity correction simultaneously; and the development of motorized intramedullary lengthening nails. However, the principles and associated complications of these techniques are on the basis of observations by Codivilla, Putti, and Abbott from as much as 110 years ago...
September 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28799316/mirror-aneurysm-with-right-frontal-ich-in-a-patient-with-osteogenesis-imperfecta
#13
Vijay Sardana, Sumit Kamble, Sunil K Sharma, Dilip Maheshwari, Bharat Bhushan
Osteogenesis imperfecta (OI) is a heterogeneous group of inherited disorders that occur owing to the abnormalities in type 1 collagen, and is characterized by increased bone fragility and other extraskeletal manifestations. OI may be associated with vascular complications such as aortic and cervical artery dissection, carotid cavernous fistula, and coronary artery aneurysms but unlike other connective tissue diseases, the cerebrovascular system is less frequently involved. We report rare case of 50 year female patient who was diagnosed with OI following right frontal haemorrhage secondary to a ruptured middle cerebral artery mirror aneurysm...
August 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28798869/a-novel-akermanite-poly-lactic-co-glycolic-acid-porous-composite-scaffold-fabricated-via-a-solvent-casting-particulate-leaching-method-improved-by-solvent-self-proliferating-process
#14
Yao Deng, Mengjiao Zhang, Xianchun Chen, Ximing Pu, Xiaoming Liao, Zhongbing Huang, Guangfu Yin
Desirable scaffolds for tissue engineering should be biodegradable carriers to supply suitable microenvironments mimicked the extracellular matrices for desired cellular interactions and to provide supports for the formation of new tissues. In this work, a kind of slightly soluble bioactive ceramic akermanite (AKT) powders were aboratively selected and introduced in the PLGA matrix, a novel l-lactide modified AKT/poly (lactic-co-glycolic acid) (m-AKT/PLGA) composite scaffold was fabricated via a solvent casting-particulate leaching method improved by solvent self-proliferating process...
August 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/28798480/magnesium-chloride-promotes-osteogenesis-through-notch-signaling-activation-and-expansion-of-mesenchymal-stem-cells
#15
Juan M Díaz-Tocados, Carmen Herencia, Julio M Martínez-Moreno, Addy Montes de Oca, Maria E Rodríguez-Ortiz, Noemi Vergara, Alfonso Blanco, Sonja Steppan, Yolanda Almadén, Mariano Rodríguez, Juan R Muñoz-Castañeda
Mesenchymal stem cells (MSC) are osteoblasts progenitors and a variety of studies suggest that they may play an important role for the health in the field of bone regeneration. Magnesium supplementation is gaining importance as adjuvant treatment to improve osteogenesis, although the mechanisms involving this process are not well understood. The objective of this study was to investigate the effects of magnesium on MSC differentiation. Here we show that in rat bone marrow MSC, magnesium chloride increases MSC proliferation in a dose-dependent manner promoting osteogenic differentiation and mineralization...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797129/differential-effects-of-amnion-and-chorion-membrane-extracts-on-osteoblast-like-cells-due-to-the-different-growth-factor-composition-of-the-extracts
#16
Yoon Young Go, Sung Eun Kim, Geum Joon Cho, Sung-Won Chae, Jae-Jun Song
Human amniotic membrane extracts contain numerous growth factors and bioactive substances. However, osteogenic effects of amnion and chorion membrane extracts (AME and CME, respectively) on osteoblasts are unclear. In this study, we explored the ability of AME and CME to promote the osteogenic differentiation of osteoblast-like MG-63 cells. MG-63 cells were cultured in osteogenic induction medium (OIM) with or without exogenous AME and CME. CME enhanced the osteogenic differentiation of MG-63 cells compared with AME, as indicated by increased mineralization; alkaline phosphatase activity; and mRNA expression of osteogenic marker genes encoding integrin-binding sialoprotein (IBSP), RUNX2, OSTERIX, and osteocalcin (OCN)...
2017: PloS One
https://www.readbyqxmd.com/read/28796986/evaluation-of-stomatognathic-problems-in-children-with-osteogenesis-imperfecta-osteogenesis-imperfecta-oi-preliminary-study
#17
Danuta Smoląg, Małgorzata Kulesa-Mrowiecka, Jerzy Sułko
According to epidemiological data, muscular dysfunctions of the masticatory system occur in 15-23% of the population. Preventive examinations of functional disorders of the stomatognathic system are, therefore, of particular importance. A distinct group of patients exposed to dysfunctions in the area of the masticatory organ locomotor apparatus comprises those with genetic diseases characterised by disorders in collagen formation. One of such diseases is osteogenesis imperfecta (OI) and dentinogenesis imperfecta that usually goes together with the former...
2017: Developmental Period Medicine
https://www.readbyqxmd.com/read/28795526/coupling-factors-and-exosomal-packaging-micrornas-involved-in-the-regulation-of-bone-remodelling
#18
Sipin Zhu, Felix Yao, Heng Qiu, Ge Zhang, Huazi Xu, Jiake Xu
Bone remodelling is a continuous process by which bone resorption by osteoclasts is followed by bone formation by osteoblasts to maintain skeletal homeostasis. These two forces must be tightly coordinated not only quantitatively, but also in time and space, and its malfunction leads to diseases such as osteoporosis. Recent research focusing on the cross-talk and coupling mechanisms associated with the sequential recruitment of osteoblasts to areas where osteoclasts have removed bone matrix have identified a number of osteogenic factors produced by the osteoclasts themselves...
August 10, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28795365/preparation-of-cell-derived-decellularized-matrices-mimicking-native-ecm-during-the-osteogenesis-and-adipogenesis-of-mesenchymal-stem-cells
#19
Takashi Hoshiba, Naoki Kawazoe, Guoping Chen
The extracellular matrix (ECM) is an important extracellular microenvironmental factor that regulates stem cell differentiation. The ECM is remodeled according to stem cell differentiation progression to precisely regulate the differentiation. Thus, it is expected that the matrices mimicking native ECM surrounding differentiating cells at each differentiation stage provide a favorable microenvironment to promote stem cell differentiation. However, it is difficult to prepare matrices mimicking native ECM using chemical methods because the ECM has a complicated composition...
August 10, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28793839/roughness-and-hydrophilicity-as-osteogenic-biomimetic-surface-properties
#20
Barbara Boyan, Ethan Major Lotz, Zvi Schwartz
Successful dental and orthopaedic implant outcomes are determined by the degree of osseointegration. Over the last 60 years, endosseous implants have evolved to stimulate osteogenesis without the need for exogenous biologics like bone morphogenetic proteins. An understanding of the interaction between cells and how cells interact with the physical features characteristics of their environments have has led to the development ofse bioactive implants. Implant surfaces that mimic the inherent chemistry, topography, and hydrophilicity wettability of native bone have been shown to provide cells in the osteoblast lineage cells with the structural cues to promote tissue regeneration and net new bone formation...
August 10, 2017: Tissue Engineering. Part A
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