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Hypothesis on carcinoma gallbladder

Feiling Feng, Qingbao Cheng, Liang Yang, Dadong Zhang, Shunlong Ji, Qiangzu Zhang, Yihui Lin, Fugen Li, Lei Xiong, Chen Liu, Xiaoqing Jiang
PURPOSE: Gallbladder sarcomatoid carcinoma is a rare cancer with no clinical standard treatment. With the rapid development of next generation sequencing, it has been able to provide reasonable treatment options for patients based on genetic variations. However, most cancer drugs are not approval for gallbladder sarcomatoid carcinoma indications. The correlation between drug response and a genetic variation needs to be further elucidated. EXPERIMENTAL DESIGN: Three patient-derived cells-JXQ-3D-001, JXQ-3D-002, and JXQ-3D-003, were derived from biopsy samples of one gallbladder sarcomatoid carcinoma patient with progression and have been characterized...
January 17, 2017: Oncotarget
Claudia Foerster, Jill Koshiol, Ariel R Guerrero, Marcelo J Kogan, Catterina Ferreccio
Chronic aflatoxin exposure has long been related to hepatocellular carcinoma (HCC). Recently, its association with gallbladder cancer (GBC) was postulated. Here we present the data supporting this hypothesis in Chile, the country with the highest GBC mortality worldwide with age-standardized mortality rates (ASMR) of 10.3 in women and 5.04 in men. The highest GBC rates occur in Southern Chile (ASMR=18), characterized by: high Amerindian ancestry, associated with high bile acid synthesis and gallstones; high poverty and high cereal agriculture, both associated with aflatoxin exposure...
January 2016: Medical Hypotheses
J B Dettoni, W Andrauss, N D Theise, M S Rocha, E S Mello, C H L Rocha, T E F Pfiffer, V A F Alves
A 62-year-old female presented with abdominal pain, weight loss of 20 kg in the prior 6 months, and a palpable mass in the right upper quadrant during physical exam. Standard liver tests, including screening for hepatitis B and C and alpha-fetoprotein were negative or within normal limits. Computerized tomography depicted a transmural gallbladder tumor infiltrating into the adjacent liver with an irregular ill-defined mass occupying segments IV-V-VI, measuring 13.0 x 9.2 x 8.5 cm, with a solid-cystic component and heterogeneous captation of endovenous contrast media...
March 2014: Pathologica
S Schlesinger, K Aleksandrova, T Pischon, M Jenab, V Fedirko, E Trepo, K Overvad, N Roswall, A Tjønneland, M C Boutron-Ruault, G Fagherazzi, A Racine, R Kaaks, V A Grote, H Boeing, A Trichopoulou, M Pantzalis, M Kritikou, A Mattiello, S Sieri, C Sacerdote, D Palli, R Tumino, P H Peeters, H B Bueno-de-Mesquita, E Weiderpass, J R Quirós, R Zamora-Ros, M J Sánchez, L Arriola, E Ardanaz, M J Tormo, P Nilsson, B Lindkvist, M Sund, O Rolandsson, K T Khaw, N Wareham, R C Travis, E Riboli, U Nöthlings
BACKGROUND: Evidence on associations between self-reported diabetes mellitus, diabetes duration, age at diabetes diagnosis, insulin treatment, and risk of biliary tract cancer (BTC) and hepatocellular carcinoma (HCC), independent of general and abdominal obesity is scarce. PATIENTS AND METHODS: We conducted a prospective analysis in the EPIC-cohort study among 363 426 participants with self-reported diabetes data. Multivariable adjusted relative risks and 95% confidence intervals were estimated from Cox regression models...
September 2013: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Erasmo Spaziani, Annalisa Di Filippo, Marcello Picchio, Piero Lucarelli, Giada Pattaro, Francesco De Angelis, Piero Francioni, Annarita Vestri, Vincenzo Petrozza, Flaminia Narilli, Francesco M Drudi, Franco Stagnitti
BACKGROUND: Adenomyomas of the gallbladder are difficult to examine during standard ultrasound examination of the abdomen. They sometimes undergo malignant transformation and their optimal management still remains a problem. The authors have aimed to investigate the ultrasonographic and histopathological prevalence of gallbladder adenomyomas focusing on the diagnostic performance of ultrasound examination. MATERIALS AND METHODS: A retrospective series of 450 consecutive patients who underwent cholecystectomy is reported...
March 2013: Annali Italiani di Chirurgia
Manuela Stancu, Irina-Draga Căruntu, Maria Sajin, Simona Giuşcă, Adriana Bădescu, Gioconda Dobrescu
AIM: The aim of the study was to perform a comparative analysis of proliferative and apoptotic activity as well as of microvascular density (MVD) in metaplasia, dysplasia and gallbladder carcinoma. MATERIAL AND METHOD: There were investigated 10 cases of chronic cholecystitis associating premalignant lesions and 5 cases of gallbladder carcinoma developed on a chronic cholecystitis background. The immunohistochemical (IHC) staining was made using Ki-67, p53 and CD34 antibodies, and the streptavidin-biotin method...
July 2007: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
A G Rizzo, M Barbuscia, M Sanò, A Cancellieri, P Nicotina, G Stassi, G Lemma, F Lemma
The authors are interested in determining causes of gallbladder cancer (GBC). By this intention, they theorize a correlation between genetic modifications (which are responsible of malignant transformation of biliary epithelium) and some intestinal infections. From 1999 to 2004 they observed 15 GBC and all 15 gallbladder have been analyzed histologically and from microbiological aspect; by these means from 1999 till 2004 they have studied also 30 persons with colelithiasis. The authors noticed that bile of both groups contained, in three cases in the first and in 8 cases in the second, a germ named Escherichia Coli which normally lives in intestine, while in 10 operated gallbladders of the first group and 12 of the second there was a positive for k-ras...
May 2005: I Supplementi di Tumori: Official Journal of Società Italiana di Cancerologia ... [et Al.]
D Tamiolakis, C Simopoulos, A Kotini, J Venizelos, T Jivannakis, P Skaphida, N Papadopoulos
OBJECTIVE: Prognosis of gallbladder carcinoma is poor. The two most important factors having the greatest effect on survival are pathologic stage of disease and histologic grade of the tumour. Our study points towards the value of HLA-DR antigen in the prognosis of gallbladder carcinoma. DESIGN: Thirty one cases of dysplasia of the gallbladder, 12 cases of carcinoma in situ, and 39 cases of invasive carcinoma for the detection of HLA-DR monoclonal antigen were studied...
November 2003: East African Medical Journal
Vlasta Vuković, Arijana Lovrencić-Huzjan, Vesna Vargek Solter, Veljko Dordević, Vida Demarin
Stroke remains the third leading cause of mortality in developed countries despite declining tendency over the past decades. As the leading cause of disability and second cause of dementia, primary prevention should be the main way to fight the disease, since therapy is not efficient enough. Several observations pointed to estrogen as a protective agent that may reduce stroke risk, however, studies have shown conflicting data. There is no strong evidence that hormone replacement therapy (HRT) increases stroke risk...
June 2003: Collegium Antropologicum
A M Hui, X Li, Y Z Shi, T Takayama, G Torzilli, M Makuuchi
This study was designed to test the hypothesis that cyclin D1 overexpression is involved in the multistep process of gallbladder carcinogenesis and can be used to predict poor prognosis for patients with gallbladder carcinoma (GBC). Cyclin D1 expression was examined immunohistochemically in a series of specimens, including 8 normal epithelia, 8 benign adenomyoma lesions, 6 precancerous adenomas, and 37 carcinomas of the gallbladder. Four of the 6 (67%) adenomas and 15 of the 37 (41%) adenocarcinomas demonstrated cyclin D1 overexpression (>5% nuclear staining), whereas all normal epithelia and adenomyoma lesions were negative for cyclin D1...
November 2000: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
L Vitetta, A Sali, P Little, L Mrazek
BACKGROUND: The present study reviewed the occurrence of gall bladder carcinoma in patients who underwent a cholecystectomy for gallstone disease. METHODS: A retrospective study of demographical and clinical information for patients who underwent a cholecystectomy and operative cholangiogram for gallstones predominantly in three major hospitals located in the northern area of Melbourne was carried out. RESULTS: Gall bladder carcinomas were observed in 14 patients (3...
September 2000: Australian and New Zealand Journal of Surgery
B E Nelson, A T Rosenfield, P E Schwartz
PURPOSE: This study was undertaken to assess the ability of computed tomography (CT) to predict the likelihood of optimal primary tumor cytoreduction in women with epithelial ovarian carcinoma. PATIENTS AND METHODS: Fifty-one women with preoperative CT and a histologic diagnosis of epithelial ovarian carcinoma following primary tumor operation by a gynecologic oncologist were identified. Forty-two CT scans were retrospectively analyzed. CT findings of attachment of the omentum to the spleen or disease greater than 2 cm on the diaphragm, liver surface, or parenchyma, pleura, mesentery, gallbladder fossa, or suprarenal paraaortic nodes were coded to represent unresectable disease...
January 1993: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
G Wyshak, M S Honeyman, J T Flannery, A S Beck
For the determination of whether mothers of dizygous (DZ) male-female twins or other polyzygous (unlike sexed) multiple births have cancer incidence different from that of controls, a cohort study was conducted with the use of the records of the Connecticut Twin Registry and the Connecticut Tumor Registry (CTR). A total of 3,982 women born between 1885 and 1935 who had borne DZ (male-female) twins or who had experienced other polyzygous multiple births in Connecticut during 1925-59 and a control group of 3,982 women, matched pairwise on year of childbirth, age, number of previous children, race, and national origin, were searched in the CTR for the incidence of cancer of all sites...
April 1983: Journal of the National Cancer Institute
A Chen, D Huminer
The preponderance of gallstones in fertile women suggests that female sex hormones play a role in the pathogenesis of cholelithiasis. In a pilot study we found estrogen receptors and high concentrations of estrogen in gallbladders of persons who underwent cholecystectomy for cholelithiasis. This finding, as well as previous reports on estrogen receptors in diverse human tumors, support the hypothesis that estrogen influences the development of gallstone disease and gallbladder carcinoma.
November 1991: Medical Hypotheses
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