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https://www.readbyqxmd.com/read/29152325/changes-of-intestinal-microbiota-composition-and-diversity-in-very-low-birth-weight-infants-related-to-strategies-of-nec-prophylaxis-protocol-for-an-observational-multicentre-pilot-study
#1
Stefan Kurath-Koller, Christine Moissl-Eichinger, Gregor Gorkiewicz, Raimund Kraschl, Claudia Kanduth, Barbara Hopfer, Berndt Urlesberger, Bernhard Resch
Background: At the Division of Neonatology, Department of Paediatrics, Medical University Graz, a unique regimen of necrotizing enterocolitis (NEC) prophylaxis in preterm infants showing a < 1500 g birth weight (i.e. very low birth weight, VLBW) is used. The regimen includes oral antibiotic and antifungal therapy and probiotic preparations as well as a standardised feeding regimen. The incidence of NEC in preterm infants treated by this regimen has been shown to be lower, reflecting 0...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29150660/gene-expression-profile-changes-in-the-jejunum-of-weaned-piglets-after-oral-administration-of-lactobacillus-or-an-antibiotic
#2
Dongyan Zhang, Tingting Shang, Yan Huang, Sixin Wang, Hui Liu, Jing Wang, Yamin Wang, Haifeng Ji, Rijun Zhang
The small intestine plays an essential role in the health and well-being of animals. Previous studies have shown that Lactobacillus has a protective effect on intestinal morphology, intestinal epithelium integrity and appropriate maturation of gut-associated tissues. Here, gene expression in jejunum tissue of weaned piglets was investigated by RNA-seq analysis after administration of sterile saline, Lactobacillus reuteri, or an antibiotic (chlortetracycline). In total, 401 and 293 genes were significantly regulated by chlortetracycline and L...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29130606/oral-administration-of-lactobacillus-plantarum-cjlp133-and-cjlp243-alleviates-birch-pollen-induced-allergic-rhinitis-in-mice
#3
S-P Choi, H-N Oh, C-Y Choi, H Ahn, H S Yun, Y M Chung, B Kim, S J Lee, T Chun
AIMS: In this study, we evaluated the therapeutic efficacy of selected probiotics in a mouse model of birch pollen (BP)-induced allergic rhinitis. METHODS AND RESULTS: Oral administration of lactobacillus plantarum CJLP133 and CJLP243 ameliorated the symptoms of BP-induced allergic rhinitis by reducing airway hyperresponsiveness (AHR), and both the histological scores and the number of infiltrated cells in the nasal cavities and lungs. Compared with those from vehicle-treated mice, bronchoalveolar lavage (BAL) fluid and draining lymph node samples from CJLP133 and CJLP243-administrated mice showed diminished numbers of immune cells, increased secretion of a Th1-type cytokine (IFN-γ), and decreased production of Th2-type cytokines (IL-4, IL-5 and IL-13)...
November 12, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29124968/probiotic-bacteria-cell-walls-stimulate-the-activity-of-the-intestinal-epithelial-cells-and-macrophage-functionality
#4
J M Lemme-Dumit, M A Polti, G Perdigón, C Maldonado Galdeano
The effect of oral administration of probiotic bacteria cell walls (PBCWs) in the stimulation of the immune system in healthy BALB/c mice was evaluated. We focused our investigation mainly on intestinal epithelial cells (IECs) which are essential for coordinating an adequate mucosal immune response and on the functionality of macrophages. The probiotic bacteria and their cell walls were able to stimulate the IECs exhibiting an important activation and cytokine releases. Supplementation with PBCWs promoted macrophage activation from peritoneum and spleen, indicating that the PBCWs oral administration was able to improve the functionality of the macrophages...
November 10, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/29121702/preventive-effects-of-a-probiotic-mixture-in-an-ovalbumin-induced-food-allergy-model
#5
Hee-Soon Shin, Ji-Eun Eom, Dong-Uk Shin, Sung-Hum Yeon, Seong-Il Lim, So-Young Lee
Although there has been a steady increase in the prevalence of food allergies worldwide in recent decades, no effective therapeutic strategies have been developed. Modulation of the gut microbiota composition and/or function through probiotics has been highlighted as a promising target for protection against food allergies. In this study, we aimed to investigate the allergy-reducing effects of a probiotic mixture (P5: Lactococcus lactis KF140, Pediococcus pentosaceus KF159, Lactobacillus pentosus KF340, Lactobacillus paracasei 698, and Bacillus amyloliquefaciens 26N) in mice with ovalbumin (OVA)-induced food allergy...
November 9, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29121411/probiotic-lactobacillus-rhamnosus-gg-prevents-alveolar-bone-loss-in-a-mouse-model-of-experimental-periodontitis
#6
Simona M Gatej, Victor Marino, Richard Bright, Tracy R Fitzsimmons, Neville Gully, Peter Zilm, Rachel J Gibson, Suzanne Edwards, Peter M Bartold
AIM: This study investigated the role of Lactobacillus rhamnosus GG on bone loss and local and systemic inflammation in an in vivo mouse model of experimental periodontitis. MATERIALS AND METHODS: Experimental periodontitis was induced in mice by oral inoculation with Porphyromonas gingivalis and Fusobacterium nucleatum over a period of 44 days. The probiotic LGG was administered via oral inoculation or oral gavage prior to, and during disease induction. The antimicrobial activity of LGG on the inoculum was also tested...
November 9, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29117309/effect-of-oral-administration-of-a-mixture-of-probiotic-strains-on-scorad-index-and-use-of-topical-steroids-in-young-patients-with-moderate-atopic-dermatitis-a-randomized-clinical-trial
#7
Vicente Navarro-López, Ana Ramírez-Boscá, Daniel Ramón-Vidal, Beatriz Ruzafa-Costas, Salvador Genovés-Martínez, Empar Chenoll-Cuadros, Miguel Carrión-Gutiérrez, José Horga de la Parte, David Prieto-Merino, Francisco M Codoñer-Cortés
Importance: Oral intake of new probiotic formulations may improve the course of atopic dermatitis (AD) in a young population. Objective: To determine whether a mixture of oral probiotics is safe and effective in the treatment of AD symptoms and to evaluate its influence on the use of topical steroids in a young population. Design, Setting, and Participants: A 12-week randomized, double-blind, placebo-controlled intervention trial, from March to June 2016, at the outpatient hospital Centro Dermatológico Estético de Alicante, Alicante, Spain...
November 8, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29114245/the-selective-interaction-of-pistacia-lentiscus-oil-vs-human-streptococci-an-old-functional-food-revisited-with-new-tools
#8
Germano Orrù, Cristina Demontis, Antonello Mameli, Enrica Tuveri, Pierpaolo Coni, Giuseppina Pichiri, Ferdinando Coghe, Antonella Rosa, Paola Rossi, Guy D'hallewin
Pistacia lentiscus berry oil (LBO) represents a typical vegetal product of the Mediterranean basin that has been formally used in traditional cuisine for 100s of years. In addition to its interesting alimentary properties, this product could represent an interesting candidate in the field of research on the study of new anti-infective agents. In fact, in Mediterranean countries, lentisk oil still continues to be widely used in folk medicine for oral and skin affections, in particular, acute gingivitis, pediatric skin infections such as impetigo and foot plaques, and biofilm related infections often associated with Streptococcus spp...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29113344/polysaccharides-from-chrysanthemum-morifolium-ramat-ameliorate-colitis-rats-by-modulating-the-intestinal-microbiota-community
#9
Jin-Hua Tao, Jin-Ao Duan, Shu Jiang, Nan-Nan Feng, Wen-Qian Qiu, Yong Ling
The gut microflora dysbiosis has been closely related with the inflammatory bowel disease (IBD). In this study, the effect of polysaccharides from Chrysanthemum morifolium Ramat on the gut microbiota was evaluated by ulcerative colitis (UC) rat model. Physiological and pathological analyses suggested that Chrysanthemum polysaccharides possessed notably protective effects on UC in vivo. Based on the Illumina MiSeq platform, 16S rRNA sequencing of the rat colonic contents indicated that the intestinal flora structure remarkably changed in the model rats and the tendency was alleviated to a certain degree by treatment with different dosages of Chrysanthemum polysaccharides...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29110293/evaluation-of-streptococcus-thermophilus-iffi-6038-microcapsules-prepared-using-an-ultra-fine-particle-processing-system
#10
Huanbin Zhou, Shunyi Li, Yao Chen, Qian Zhang, Xuequn Bai, Chune Zhu, Hu Liu, Lili Wang, Chuanyu Wu, Xin Pan, Chuanbin Wu
Microencapsulation technology has the potential to protect probiotics and to deliver them to the gut, and extrusion is one of the most commonly used methods. However, the rather large diameters of 1~5 mm produced tend to cause oral grittiness and result in low compliance. In this article, Streptococcus thermophilus IFFI 6038 (IFFI 6038) microcapsules were prepared using an ultra-fine particle processing system (UPPS) previously developed by this research group. IFFI 6038 suspension was pumped by a peristaltic pump to the feeding inlet nozzle and then dispersed into micro-droplets by a rotating disk, followed by solidification...
November 6, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29109537/neuroprotective-effect-of-ruminococcus-albus-on-oxidatively-stressed-sh-sy5y-cells-and-animals
#11
Jieun Park, Jiyun Lee, Zia Yeom, Donghyuk Heo, Young-Hee Lim
Recent evidence shows that the gut microbiota has an important role in gut-brain crosstalk and is linked to neuronal disorders. The aim of this study was to investigate the effects of intestinal Ruminococcus albus with probiotic potential on neuroprotection in oxidatively stressed SH-SY5Y neuroblastoma cells and animals. To investigate these effects, conditioned medium was prepared using Caco-2 cells cultured with heat-killed R. albus (CRA-CM). Caco-2 cells cultured with heat-killed R. albus showed increased BDNF expression and BDNF protein levels increased in CRA-CM...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29102544/gut-microbiota-and-hypertension-from-pathogenesis-to-new-therapeutic-strategies
#12
Yongbo Kang, Yue Cai
Hypertension (HTN) has become a global public health concern and a major risk factor for cardiovascular, cerebrovascular, and kidney diseases. The complex interplay of genetic and environmental influences is important for the development of the disease. Accumulating evidence has illustrated the association of dysbiosis of gut microbiota with hypertension. Certain gut microbial strains may play either a pathogenic or a protective role in the development of hypertension. Oral probiotics can therefore represent a therapeutic approach for hypertension treatment...
November 1, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29101668/gut-microbiota-are-disease-modifying-factors-after-traumatic-spinal-cord-injury
#13
REVIEW
Kristina A Kigerl, Klauss Mostacada, Phillip G Popovich
Spinal cord injury (SCI) disrupts the autonomic nervous system (ANS), impairing its ability to coordinate organ function throughout the body. Emerging data indicate that the systemic pathology that manifests from ANS dysfunction exacerbates intraspinal pathology and neurological impairment. Precisely how this happens is unknown, although new data, in both humans and in rodent models, implicate changes in the composition of bacteria in the gut (i.e., the gut microbiota) as disease-modifying factors that are capable of affecting systemic physiology and pathophysiology...
November 3, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29100403/lactobacillus-reuteri-zj617-maintains-intestinal-integrity-via-regulating-tight-junction-autophagy-and-apoptosis-in-mice-challenged-with-lipopolysaccharide
#14
Yanjun Cui, Li Liu, Xiaoxiao Dou, Chong Wang, Wenming Zhang, Kan Gao, Jianxin Liu, Haifeng Wang
Live probiotics are effective in reducing gut permeability and inflammation. We have previously reported that Lactobacillus reuteri ZJ617 (ZJ617) with high adhesive and Lactobacillus rhamnosus GG (LGG) can ameliorate intestine inflammation induced by lipopolysaccharide (LPS). The present study was aimed at elucidating the roles of ZJ617 and LGG in alleviating the LPS-induced barrier dysfunction of ileum in mice. Six C57BL/6 mice per group were orally inoculated with ZJ617 or LGG for one week (1× 10(8) CFU/mouse) and intraperitoneally injected with LPS (10 mg/kg body weight) for 24 h...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29097999/clostridium-butyricum-cgmcc0313-1-protects-against-autoimmune-diabetes-by-modulating-intestinal-immune-homeostasis-and-inducing-pancreatic-regulatory-t-cells
#15
Lingling Jia, Kai Shan, Li-Long Pan, Ninghan Feng, Zhuwu Lv, Yajun Sun, Jiahong Li, Chengfei Wu, Hao Zhang, Wei Chen, Julien Diana, Jia Sun, Yong Q Chen
Recent evidence indicates that indigenous Clostridium species induce colonic regulatory T cells (Tregs), and gut lymphocytes are able to migrate to pancreatic islets in an inflammatory environment. Thus, we speculate that supplementation with the well-characterized probiotics Clostridium butyricum CGMCC0313.1 (CB0313.1) may induce pancreatic Tregs and consequently inhibit the diabetes incidence in non-obese diabetic (NOD) mice. CB0313.1 was administered daily to female NOD mice from 3 to 45 weeks of age. The control group received an equal volume of sterile water...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29094223/can-probiotic-supplements-improve-outcomes-in-rheumatoid-arthritis
#16
REVIEW
Annemarie Schorpion, Sharon L Kolasinski
PURPOSE OF REVIEW: The purpose of this review is to frame the discussion of the potential use of probiotics for the management of rheumatoid arthritis (RA) in the historical and scientific context linking the human microbiota to the etiology, pathogenesis, and treatment of RA. Given this context, the review then details the clinical trials that have been carried out so far that have tried to address the question. RECENT FINDINGS: A variety of laboratory and clinical observations link the flora of the oral cavity and lower gastrointestinal tract with citrullination, as well as immunological alterations that may contribute to the risk of developing RA...
November 2, 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29081213/lactobacillus-plantarum-c29-alleviates-tnbs-induced-memory-impairment-in-mice
#17
Hae-Ji Lee, Jin-Ju Jeong, Myung Joo Han, Dong-Hyun Kim
In the preliminary study, Lactobacillus plantarum C29 was found to suppress 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Therefore, to understand whether an anti-colitic probiotic C29 could attenuate memory impairment, we examined the effects of C29 on TNBS-induced memory impairment in mice. Orally administered Lactobacillus plantarum C29 attenuated TNBS-induced memory impairment in Y-maze, noble object, and tasks. C29 treatment increased TNBS-suppressed hippocampal BDNF expression and inhibited TNBS-induced hippocampal NF-κB activation and blood LPS levels...
October 31, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29080807/safety-evaluation-of-howaru-%C3%A2-restore-lactobacillus-acidophilus-ncfm-lactobacillus-paracasei-lpc-37-bifidobacterium-animalis-subsp-lactis-bl-04-and-b-lactis-bi-07-for-antibiotic-resistance-genomic-risk-factors-and-acute-toxicity
#18
Wesley Morovic, Jason M Roper, Amy B Smith, Pushkor Mukerji, Buffy Stahl, Jessica Caverly Rae, Arthur C Ouwehand
Although probiotic lactobacilli and bifidobacteria are generally considered safe by various regulatory agencies, safety properties, such as absence of transferable antibiotic resistance, must still be determined for each strain prior to market introduction as a probiotic. Safety requirements for probiotics vary regionally and evaluation methods are not standardized, therefore methodologies are often adopted from food ingredients or chemicals to assess microbial safety. Four individual probiotic strains, Lactobacillus acidophilus NCFM(®), Lactobacillus paracasei Lpc-37(®), Bifidobacterium animalis subsp...
November 1, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29080295/effect-of-riboflavin-producing-bacteria-against-chemically-induced-colitis-in-mice
#19
Romina Levit, Graciela Savoy de Giori, Alejandra de Moreno de LeBlanc, Jean Guy LeBlanc
AIM: To assess the anti-inflammatory effect associated to individual probiotic suspensions of riboflavin-producing lactic acid bacteria (LAB) in a colitis murine model. METHODS AND RESULTS: Mice intrarectally inoculated with trinitrobenzene sulfonic acid (TNBS) were orally administered with individual suspensions of riboflavin-producing strains: Lactobacillus (Lact.) plantarum CRL2130, Lact. paracasei CRL76, Lact. bulgaricus CRL871, Streptococcus thermophilus CRL803; a non riboflavin-producing strain or commercial riboflavin...
October 27, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29078062/two-probiotic-bacillus-spores-enhance-cellular-immunity-in-balb-c-mice
#20
Li Gong, Qin Huang, Aikun Fu, Yanping Wu, Ya-Li Li, Xiaogang Xu, Yi Huang, Dong-You Yu, Wei-Fen Li
Previous studies found that Bacillus subtilis BS02 (B. subtilis BS02) and B. subtilis subsp. natto BS04 (B. subtilis natto BS04) isolated in our laboratory could activate immune response of murine macrophages in vitro. This study aims to investigate the effects of dietary supplementation with Bacillus spores on the systemic cellular immune response in BALB/C mice. Results showed that both B. subtilis BS02 and B. subtilis natto BS04 enhanced the phagocytic function of mononuclear phagocyte system (MPS) and the cytotoxicity of natural killer (NK) cells...
October 27, 2017: Canadian Journal of Microbiology
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