Read by QxMD icon Read


Mohammed Sami Alhaddad, Afnan Khalifah AlBarjas, Lolowah Ebraheem Alhammar, Abdullatif Sami Al Rashed, Lorina Ineta Badger-Emeka
Background: Acinetobacter baumannii , is an emerging nosocomial multidrug resistance pathogen with the rapid spread of clones being reported in health-care settings and hospitals worldwide. Carbapenem resistance in this bacterium has been attributed to D OXA β-lactamases with OXA-51-like β-lactamase, being present in all A. baumannii isolate. The present study looks into the antibiotics susceptibility and molecular characterization of clinical A. baumannii isolates from Intensive Care Unit (ICU) samples in Al-Hofuf, South-eastern region of Saudi Arabia...
January 2018: International Journal of Applied and Basic Medical Research
Luís P Carmo, Liza R Nielsen, Lis Alban, Paulo M da Costa, Gertraud Schüpbach-Regula, Ioannis Magouras
Reducing antimicrobial use (AMU) in livestock is requested by Public Health authorities. Ideally, this should be achieved without jeopardizing production output or animal health and welfare. Thus, efficient measures must be identified and developed to target drivers of AMU. Veterinarians play a central role in the identification and implementation of such efficient interventions. Sixty-seven veterinarians with expertise in livestock production in Denmark, Portugal, and Switzerland participated in an expert opinion study aimed at investigating experiences and opinions of veterinarians about the driving forces and practices related to AMU in the main livestock sectors (broiler, dairy cattle, fattening/veal calf, and pig industry) of the aforementioned countries...
2018: Frontiers in Veterinary Science
Shuguang Li, Shijun Sun, Chentao Yang, Hongbin Chen, Yuyao Yin, Henan Li, Chunjiang Zhao, Hui Wang
To investigate the epidemiology and genetic structure of Staphylococcus aureus bacteremia in China, a total of 416 isolates from 22 teaching hospitals in 12 cities from 2013 and 2016 were characterized by antibiogram analysis, multilocus sequence typing (MLST), spa typing and staphylococcal cassette chromosome mec (SCC mec ) typing. The predominant meticillin-susceptible (MSSA) genotypes in 2013 were ST188 (19.1%), ST7 (8.7%), and ST398 (7.8%), respectively, and they continued to be the main genotypes in 2016...
2018: Frontiers in Microbiology
Andrew J Page, Alexander Wailan, Yan Shao, Kim Judge, Gordon Dougan, Elizabeth J Klemm, Nicholas R Thomson, Jacqueline A Keane
Increasingly rich metadata are now being linked to samples that have been whole-genome sequenced. However, much of this information is ignored. This is because linking this metadata to genes, or regions of the genome, usually relies on knowing the gene sequence(s) responsible for the particular trait being measured and looking for its presence or absence in that genome. Examples of this would be the spread of antimicrobial resistance genes carried on mobile genetic elements (MGEs). However, although it is possible to routinely identify the resistance gene, identifying the unknown MGE upon which it is carried can be much more difficult if the starting point is short-read whole-genome sequence data...
March 12, 2018: Microbial Genomics
Michael Hornsey, David W Wareham
Multidrug-resistant lineages of Acinetobacter baumannii (MDRAB) are important nosocomial pathogens. As tigecycline remains active against most MDRAB we sought to investigate whether tigecycline resistance impacts biological fitness. The effects of treatment-emergent tigecycline resistance were investigated in vitro and in vivo using two pre- (AB210; W6976) and post-therapy (AB211; W7282) clinical pairs, recovered from individual patients, where tigecycline resistance was associated with up-regulated efflux activity...
March 9, 2018: Scientific Reports
Li-Oon Chuah, Ahamed-Kamal Shamila Syuhada, Ismail Mohamad Suhaimi, Tajudin Farah Hanim, Gulam Rusul
This article describes the Pulsed-field gel electrophoresis clustering of the predominant Salmonella strains ( Salmonella ser. Albany, Salmonella ser. Brancaster, and Salmonella ser. Corvallis) isolated from poultry and processing environment in wet market and small-scale processing plant in Penang and Perlis, the northern states of Malaysia. Agar disk diffusion assay was performed to determine the phenotypic antibiotic resistance of these Salmonella strains. The most common antibiograms among the three predominant Salmonella serovars were reported...
April 2018: Data in Brief
Yasuo Ohkoshi, Toyotaka Sato, Takayuki Wada, Yukari Fukushima, Hiromi Murabayashi, Yasunari Takakuwa, Kaoru Nishiyama, Hiroyuki Honda, Tsukasa Shiraishi, Koji Kuronuma, Hiroki Takahashi, Chie Nakajima, Yasuhiko Suzuki, Shin-Ichi Yokota
Multidrug-resistant Streptococcus pneumoniae strains were isolated from blood and sputum of a patient with disseminated intravascular coagulation in Sapporo city, Japan. These antibiograms were only susceptible to vancomycin, linezolid, daptomycin, some carbapenems, and some fluoroquinolones. Identical antibiograms, serotypes (19F), and sequence types (ST10017) suggested a shared origin of these isolates. Only one ST10017 strain has been isolated in the same city in Japan previously (2014), and the 2014 isolate is still susceptible to macrolides...
February 26, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Gregory B Tallman, Rowena A Vilches-Tran, Miriam R Elman, David T Bearden, Jerusha E Taylor, Paul N Gorman, Jessina C McGregor
OBJECTIVE To assess general medical residents' familiarity with antibiograms using a self-administered survey DESIGN Cross-sectional, single-center survey PARTICIPANTS Residents in internal medicine, family medicine, and pediatrics at an academic medical center METHODS Participants were administered an anonymous survey at our institution during regularly scheduled educational conferences between January and May 2012. Questions collected data regarding demographics, professional training; further open-ended questions assessed knowledge and use of antibiograms regarding possible pathogens, antibiotic regimens, and prescribing resources for 2 clinical vignettes; a series of directed, closed-ended questions followed...
March 1, 2018: Infection Control and Hospital Epidemiology
Shahram Mobaraki, Mohammad Aghazadeh, Mohammad Hossein Soroush Barhaghi, Mohammad Yousef Memar, Hamid Reza Goli, Pourya Gholizadeh, Hossein Samadi Kafil
BACKGROUND: The presence of Class 1, 2 and 3 integrons in clinical isolates of Pseudomonas aeruginosa with multi-drug resistance phenotype has rendered the organism as a new concern. OBJECTIVE: This study aimed to investigate the prevalence of Class 1, 2 and 3 integrons in multi-drug resistant clinical isolates of Pseudomonas aeruginosa collected from hospitals in the city of Tabriz Materials and Methods: A total of 200 P. aeruginosa non-duplicated clinical isolates were collected from inpatients and outpatients in different wards of hospitals from May to November 2016...
March 2018: BioMedicine
Qifa Song, Junhua Wu, Peisen Ruan
PURPOSE: To investigate the distribution of molecular types of methicillin-resistant Staphylococcus aureus (MRSA) in a paediatric intensive care unit (PICU) according to their community-associated (CA) and hospital-associated (HA) source of acquisition, and thus assess the degree to which CA-MRSA has been introduced into the PICU. METHODOLOGY: We implemented an MRSA surveillance in a PICU during 2013-2016 and investigated the genetic diversity of the isolates retrospectively using three genetic typing methods, as well as antibiograms and virulence factor profiles...
February 5, 2018: Journal of Medical Microbiology
Samuel Girma, Mekonnen Sisay, Getnet Mengistu, Firehiwot Amare, Dumessa Edessa
Background: Antimicrobials are among the most frequently prescribed medications for pediatric patients. However, inappropriate use of them can increase morbidity, mortality, healthcare costs, and largely antimicrobial resistance. This study aims to assess the antimicrobial utilization pattern in the pediatric ward of Hiwot Fana Specialized University Hospital. Methods: Retrospective cross-sectional study was conducted to assess the antimicrobial utilization. In this study, 403 pediatric medical records selected by systematic random sampling were reviewed...
February 2018: Hospital Pharmacy
Chaitra Shankar, Balaji Veeraraghavan, Laura Eve Buchnan Nabarro, Raji Ravi, Naveen Kumar Devanga Ragupathi, Priscilla Rupali
BACKGROUND: Hypervirulent K. pneumoniae (hvKp) causes severe community acquired infections, predominantly in Asia. Though initially isolated from liver abscesses, they are now prevalent among invasive infections such as bacteraemia. There have been no studies reported till date on the prevalence and characterisation of hvKp in India. The objective of this study is to characterise the hypervirulent strains isolated from bacteraemic patients for determination of various virulence genes and resistance genes and also to investigate the difference between healthcare associated and community acquired hvKp with respect to clinical profile, antibiogram, clinical outcome and molecular epidemiology...
January 8, 2018: BMC Microbiology
Alberto Romero Palacios, Fahad Al Dhufairi, Chelsey Ellis, Daniel Smyth, Lorraine Maze Dit Mieusement, Allison McGeer, Dominik Mertz
Antibiograms of urine cultures are being used to guide empiric treatment for urinary tract infections (UTI). However, roughly 50% of urine cultures are from patients with asymptomatic bacteriuria (ABU). It is unclear whether enterobacteriaceae in ABU patients have similar resistance patterns as UTI patients. Hence, we aimed to compare the antimicrobial resistance patterns in patients with ABU to patients with symptomatic UTI. We found no major differences in resistance patterns, and therefore, empiric treatment choices can be guided by antibiograms that include ABU patients...
February 9, 2018: Journal of Hospital Infection
Sybille Chatelain, Tommaso Lombardi, Paolo Scolozzi
PURPOSE: We analyzed the data from a series of patients with dental implant-related suppurative osteomyelitis of the jaws (DIOMJ) due to Streptococcus anginosus. PATIENTS AND METHODS: The medical records of all patients seen for osteomyelitis of the jaws from 2011 to 2016 were reviewed. The primary outcome variable was Streptococcus anginosus DIOMJ. Other variables included age, gender, smoking habits, associated comorbidities, dental implant localization, type of osteomyelitis, delay between dental implant placement and DIOMJ, microbiologic examination and antibiogram, antibiotherapy, type of surgery, and final outcome...
January 31, 2018: Journal of Oral and Maxillofacial Surgery
Hang Pan, Narayan Paudyal, Xiaoliang Li, Weihuan Fang, Min Yue
Characterization of transmission routes of Salmonella among various food-animal reservoirs and their antibiogram is crucial for appropriate intervention and medical treatment. Here, we analyzed 3728 Salmonella enterica serovar Newport ( S. Newport) isolates collected from various food-animals, retail meats and humans in the United States between 1996 and 2015, based on their minimum inhibitory concentration (MIC) toward 27 antibiotics. Random Forest and Hierarchical Clustering statistic was used to group the isolates according to their MICs...
2018: Frontiers in Microbiology
Tetsu Ohnuma, Yoshiro Hayashi, Kazuto Yamashita, John Marquess, Alan Kawarai Lefor, Masamitsu Sanui
Although a majority of patients in the intensive care unit (ICU) receive antibiotics, little is known about patterns of antibiotic use in ICUs in Japan. The objective of this study was to evaluate the pattern of antibiotic use in ICUs. A nationwide one-day cross-sectional surveillance of antibiotic use in the ICU was conducted three times between January 2011 and December 2011. All patients aged ≧16-years old were included. Data from 52 ICUs and 1148 patients were reviewed. There were 1028 prescriptions for intravenous antibiotics...
February 1, 2018: International Journal of Antimicrobial Agents
Elizabeth Salsgiver, Daniel Bernstein, Matthew S Simon, Daniel P Eiras, William Greendyke, Christine J Kubin, Monica Mehta, Brian Nelson, Angela Loo, Liz G Ramos, Haomiao Jia, Lisa Saiman, E Yoko Furuya, David P Calfee
OBJECTIVE To assess antimicrobial prescriber knowledge, attitudes, and practices (KAP) regarding antimicrobial stewardship (AS) and associated barriers to optimal prescribing. DESIGN Cross-sectional survey. SETTING Online survey. PARTICIPANTS A convenience sample of 2,900 US antimicrobial prescribers at 5 acute-care hospitals within a hospital network. INTERVENTION The following characteristics were assessed with an anonymous, online survey in February 2015: attitudes and practices related to antimicrobial resistance, AS programs, and institutional AS resources; antimicrobial prescribing and AS knowledge; and practices and confidence related to antimicrobial prescribing...
February 6, 2018: Infection Control and Hospital Epidemiology
Yong-Hua Gao, Wei-Jie Guan, Ya-Nan Zhu, Rong-Chang Chen, Guo-Jun Zhang
Background and aims: Pseudomonas aeruginosa (PA) is the most common pathogen in bronchiectasis and frequently develops resistance to multiple classes of antibiotics, but little is known about the clinical impacts of PA-resistant (PA-R) isolates on bronchiectasis. We, therefore, investigated the prevalence, risk factors and prognostic implications of PA-R isolates in hospitalized bronchiectasis patients. Patients and methods: Between June 2011 and July 2016, data from adult bronchiectasis patients isolated with PA at the First Affiliated Hospital of Zhengzhou University were retrospectively analyzed...
2018: International Journal of Chronic Obstructive Pulmonary Disease
David Garrido, Santiago Garrido, Miguel Gutiérrez, Leonel Calvopiña, Amani Sunday Harrison, Michelle Fuseau, Ramiro Salazar Irigoyen
BACKGROUND: Urinary tract infections (UTI) are among the most common infections in pediatric patients. The main etiopathogenic agent is Escherichia coli. The purpose of this study was to determine the antimicrobial resistance pattern of E. coli in pediatric patients and to understand their main clinical and laboratory manifestations. METHODS: Fifty-nine patients were included in the study and classified into two groups: hospitalization (H) and external consultation (EC)...
July 2017: Boletín Médico del Hospital Infantil de México
Lars Helbig, Maren Bechberger, Riyadh Aldeeri, Adriana Ivanova, Patrick Haubruck, Matthias Miska, Gerhard Schmidmaier, Georg W Omlor
Purpose: Infected nonunions of the long bones belong to the most feared complications in the field of orthopedic and trauma surgery. Optimal antibiotic therapy should start early with the first revision surgery. Therefore, the aim of this study was to evaluate our peri- and postoperative antibiotic regime in context with the microbial spectrum and antibiotic resistances of patients with infected nonunions and to assess the possible impact on healing rates. Methods: We included all patients with first revision surgery during 2010-2015 due to nonunion of long bones with a clinical history of infection treated with radical debridement, local application of a gentamicin-impregnated bone cement, and systemic cefuroxime...
2018: Therapeutics and Clinical Risk Management
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"