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https://www.readbyqxmd.com/read/27911920/sirna-targeting-mtor-effectively-prevents-the-proliferation-and-migration-of-human-lens-epithelial-cells
#1
Chunmei Zhang, Jingjing Liu, Na Jin, Guiming Zhang, Yahui Xi, Hongling Liu
Posterior capsule opacification (PCO) is the most common complication that causes visual decrease after extracapsular cataract surgery. The primary cause of PCO formation is the proliferation of the residual lens epithelial cells (LECs). The mammalian target of rapamycin (mTOR) plays an important role in the growth and migration of LECs. In the current study, we used small interfering RNA (siRNA) to specifically attenuate mTOR in human lens epithelial B3 cells (HLE B3). We aimed to examine the effect of mTOR-siRNA on the proliferation, migration and epithelial-to-mesenchymal transition (EMT) of HLE B3 cells and explore the underlying mechanisms...
2016: PloS One
https://www.readbyqxmd.com/read/27911426/-ocular-hydrodynamics-after-phacoemulsification-cataract-surgery-in-patients-with-primary-open-angle-glaucoma
#2
E A Kalizhnikova, O I Lebedev, O V Shchipacheva, G G Pecheritsa
AIM: To investigate parameters of intraocular fluid outflow after phacoemulsification of cataract in patients with primary open-angle glaucoma (POAG). MATERIAL AND METHODS: The study involved 153 cataract patients (153 eyes), most of whom also had POAG. The patients were divided into three groups: group 1 - 51 patients (51 eyes) with cataract but no glaucoma, group 2 - 51 patients (51 eyes) with cataract and early POAG, and group 3 - 51 patients (51 eyes) with cataract and advanced POAG...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27911420/-role-of-immunological-factors-in-the-development-of-myopic-choroidal-neovascularization
#3
A G Shchuko, N V Zaitseva, T N Yur'eva, E R Chernykh, I M Mikhalevich, A V Grigor'eva
AIM: To study the concentration of cytokines in the aqueous humor of the anterior chamber in patients with myopic choroidal neovascularization (mCNV) and to compare the results to their ophthalmic status. MATERIAL AND METHODS: A total of 19 patients (19 eyes) with mCNV treated with intravitreal ranibizumab were included in the study. The control group consisted of 15 patients (15 eyes) with myopia who had cataract surgery. Age, sex, and refractive error distribution were similar to that in the study group...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27906556/combination-effect-of-cefuroxime-and-levofloxacin-against-bacteria-isolated-from-the-healthy-conjunctival-sac-and-endophthalmitis-cases-using-a-fractional-inhibitory-concentration-index
#4
Takashi Suzuki, Toshihiro Yamamoto, Tomohiko Torikai, Yuichi Ohashi
PURPOSE: Intracameral cefuroxime (CXM) and antibiotic eye drops such as fluoroquinolone are widely used for preventing endophthalmitis after cataract surgery. However, few reports are available regarding their interactions. This study was conducted to examine the in vitro interaction of CXM and levofloxacin (LVFX) against bacterial isolates from the healthy conjunctival sac before cataract surgery and from endophthalmitis cases. METHODS: The activity of each drug was determined using a broth dilution method...
December 1, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27905889/influence-of-posterior-corneal-astigmatism-on-postoperative-refractive-astigmatism-in-pseudophakic-eyes-after-cataract-surgery
#5
Maki Sano, Takahiro Hiraoka, Yuta Ueno, Hideo Itagaki, Tomohiro Ogami, Tetsuro Oshika
BACKGROUND: To examine the influence of posterior corneal astigmatism on postoperative refractive astigmatism in pseudophakic eyes after cataract surgery. METHODS: The study enrolled 64 pseudophakic eyes of 50 patients (71.8 ± 9.9 years old, mean ± standard deviation) who had undergone phacoemulsification with non-toric IOL implantation. Refractive astigmatism was measured using an auto ref-keratometer with a 0.01- diopter (D) scale. Two types of corneal astigmatism were calculated using anterior segment optical coherence tomography; keratometric and total corneal astigmatism...
December 1, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27905333/effect-of-cataract-surgery-on-intraocular-pressure-in-supine-and-lateral-decubitus-body-postures
#6
Ji-Hye Park, Chungkwon Yoo, Jong-Suk Song, Shan C Lin, Yong Yeon Kim
PURPOSE: To investigate the effect of phacoemulsification on intraocular pressure (IOP) in different recumbent body postures including supine and lateral decubitus (LD) positions. MATERIALS AND METHODS: This prospective, observational study included patients who had no glaucoma and who had planned to undergo phacoemulsification and intraocular lens implantation in one eye. Before and 1 month after cataract surgery, IOP was measured in both eyes using the Tono-Pen AVIA...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27902443/association-between-cataract-and-risk-of-incident-atrial-fibrillation-a-nationwide-population-based-retrospective-cohort-study
#7
Wei-Syun Hu, Cheng-Li Lin
OBJECTIVE: To identify the association between cataract and the subsequent atrial fibrillation (AF) risk. PATIENTS AND METHODS: Our retrospective cohort study was designed to analyze the Longitudinal Health Insurance Database 2000 of the Taiwan National Health Insurance program. We established a cataract cohort (n=39,347) and a noncataract cohort (n=39,347) to observe the incidence of AF. The cataract cohort included patients who were newly diagnosed with cataract from January 1, 2000, to December 31, 2010...
October 27, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27899084/clinical-outcomes-of-a-new-diffractive-trifocal-intraocular-lens-with-enhanced-depth-of-focus-edof
#8
Banu Torun Acar, Erkan Duman, Saban Simsek
BACKGROUND: To evaluate the clinical outcomes after the implantation of a new trifocal diffractive intraocular lens (IOL) combined with Enhanced depth of focus (EDOF) technology. METHODS: The study enrolled 80 eyes of 40 patients who underwent cataract surgery with bilateral implantation of a diffractive trifocal IOL (Reviol Tri-ED) designed with a combination of enhanced depth of focus. Mean age was 52.09 ± 11.32 years (range from 45 to 70 years). Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), uncorrected intermediate visual acuity (UIVA), corrected intermediate visual acuity (CIVA), uncorrected near visual acuity (UNVA), corrected near visual acuity (CNVA), keratometry (K), and manifest refraction spherical equivalent (MRSE) were evaluated pre- and postoperatively...
November 29, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27898468/update-on-ciliary-body-laser-procedures
#9
Behzad Amoozgar, Eileen N Phan, Shan C Lin, Ying Han
PURPOSE OF REVIEW: There are currently various options available for glaucoma treatment procedures ranging from laser to penetrating to nonpenetrating surgeries. Innovations in glaucoma surgical therapeutics include features such as external application, focused tissue effects, and minimal manipulation as these factors all help lower the risk of side-effects in addition to increasing the success rate of the treatment. Traditional diode laser transscleral cyclophotocoagulation (TSCPC) is invasive and destructive...
November 25, 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27898449/modern-phacoemulsification-and-intraocular-lens-implantation-refractive-lens-exchange-is-safe-and-effective-in-treating-high-myopia
#10
Bhaskar Srinivasan, Hiu Ying Leung, He Cao, Shu Liu, Lizhen Chen, Alex Hoi Fan
Improved efficacy, predictability, and safety of modern phacoemulsification have resulted in cataract surgery being considered as a refractive procedure. Refractive lens exchange by definition is a surgery aimed at replacing the cataractous or clear crystalline lens with an intraocular lens (IOL) in cases of high ametropia. The excellent intraocular optics of this procedure provide a better visual outcome as compared with laser refractive surgery in high myopia. With advances in technology and IOL formulas, the predictability of refractive outcome after cataract surgery in high myopes has improved...
November 2016: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/27898441/epidemiology-of-myopia
#11
Pei-Chang Wu, Hsiu-Mei Huang, Hun-Ju Yu, Po-Chiung Fang, Chueh-Tan Chen
Myopia is not a simple refractive error, but an eyesight-threatening disease. There is a high prevalence of myopia, 80% to 90%, in young adults in East Asia; myopia has become the leading cause of blindness in this area. As the myopic population increases globally, the severity of its impact is predicted. Approximately one fifth of the myopic population has high myopia (≥-6 diopters), which results in irreversible vision loss such as retinal detachment, choroidal neovascularization, cataracts, glaucoma, and macular atrophy...
November 2016: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/27897120/dropless-cataract-surgery-an-overview
#12
Richard L Lindstrom, M Stewart Galloway, Andrzej Grzybowski, Jeffrey T Liegner
Risk reduction and the attainment of good outcomes in contemporary cataract surgery depend in part on patient compliance with a postoperative regimen of topical eye drops. Topical drops are expensive and challenging to instill properly for patients. The consequences of noncompliance or poor compliance can be significant for the patient (in the case of a complication) and for society (in the case of development of antibiotic resistance). For all of these reasons, new approaches that reduce the need for topical therapy are beginning to emerge, including intracameral injection, sustained or slow-release drug delivery mechanisms, and the recently introduced "Dropless cataract surgery," which involves intravitreal injection of single-use, compounded combination of antibiotics and corticosteroids...
November 29, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27889501/endophthalmitis-after-clear-corneal-cataract-surgery-outcomes-over-two-decades
#13
Nicolas A Yannuzzi, Nancy Si, Nidhi Relhan, Ajay E Kuriyan, Thomas A Albini, Audina M Berrocal, Janet L Davis, William E Smiddy, Justin Townsend, Darlene Miller, Harry W Flynn
PURPOSE: To report the clinical features, causative organisms, and visual acuity (VA) outcomes associated with acute-onset endophthalmitis after clear corneal cataract surgery over the past two decades. DESIGN: Retrospective case series. METHODS: Clinical and microbiology records were reviewed for 63 eyes of 63 patients who presented to a tertiary referral center between 2006 and 2015 with culture-positive endophthalmitis occurring within 6 weeks of clear corneal cataract surgery...
November 23, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27887598/comparison-of-the-most-common-isolates-of-postoperative-endophthalmitis-in-south-korea-enterococcus-species-vs-coagulase-negative-staphylococci
#14
Ki Yup Nam, Hyun Wong Kim, Woo Jin Jeung, Jung Min Park, Jong Moon Park, In Young Chung, Yong Seop Han, Bu Sup Oum, Ji Eun Lee, Ik Soo Byon, Il Han Yun, Joo Eun Lee, Hee Sung Yoon, Dong Park, Byeng Chul Yu, Sang Joon Lee
BACKGROUND: To compare the related factors or manifestations of the two most common isolates of post-operative endophthalmitis, which were Enterococcus spp. and coagulase-negative staphylococci (CNS) in South Korea. METHODS: Medical records were reviewed for cases of post-operative endophthalmitis caused by Enterococcus spp. and CNS at eight institutions between January 2004 and July 2010. Various factors including age, sex, residence, systemic diseases, smoking and drinking history, and best corrected visual acuity, and length of time between causative intraocular surgery and symptom development were compared between the two groups...
November 25, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27885591/the-impact-of-non-steroidal-anti-inflammatory-agents-after-phacoemulsification-on-quality-of-life-a-randomized-study
#15
Irini P Chatziralli, Theodoros N Sergentanis, Efstratios A Parikakis, Leonidas E Papazisis, Panagiotis Mitropoulos, Marilita M Moschos
INTRODUCTION: The purpose of our study was to investigate the impact of ketorolac addition to the well-established combination of antibiotic-steroid agent in terms of vision-related quality of life. METHODS: Patients were randomized to: (1) fixed combination of tobramycin 0.3%-dexamethasone 0.1%, one drop qid (n = 68) and (2) fixed combination of tobramycin 0.3%-dexamethasone 0.1%, one drop qid, plus ketorolac tromethamine 0.5%, one drop tid (n = 70). All patients completed the VFQ-25 questionnaire to assess their functional vision before cataract surgery and postoperatively on days 7, 28 and 42...
November 24, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27882513/comparison-of-clinico-microbiological-profile-and-treatment-outcome-of-in-house-and-referred-post-cataract-surgery-endophthalmitis-in-a-tertiary-care-center-in-south-india
#16
Vikas Ambiya, Taraprasad Das, Savitri Sharma, Jay Chhablani, Vivek Dave, Subhadra Jalali, Raja Narayanan, Joveeta Joseph
BACKGROUND: The purpose of the study is to compare the clinico-microbiological profile and treatment outcome of in-house vs referred cases of post cataract surgery endophthalmitis in a tertiary eye care facility in South India. METHODS: The clinical records of 50 culture-positive cases each of in-house (group A) and referred (group B) post cataract surgery endophthalmitis were analyzed. The management protocol was similar in both groups. RESULTS: The time to report to the institute was longer in group B (group B 13...
December 2016: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/27882243/glaukos-istent-inject%C3%A2-trabecular-micro-bypass-implantation-associated-with-cataract-surgery-in-patients-with-coexisting-cataract-and-open-angle-glaucoma-or-ocular-hypertension-a-long-term-study
#17
Pedro Arriola-Villalobos, Jose Maria Martinez-de-la-Casa, David Diaz-Valle, Laura Morales-Fernandez, Cristina Fernandez-Perez, Julian Garcia-Feijoo
Purpose. To evaluate the long-term efficacy and safety of the iStent inject device (Glaukos Corporation, Laguna Hills, CA) combined with phacoemulsification in patients with coexistent cataract and open-angle glaucoma or ocular hypertension (OHT). Methods. A prospective, uncontrolled, nonrandomized, interventional case series study was conducted in patients with both mild or moderate open-angle glaucoma or OHT and cataract. Patients underwent cataract surgery along with the implant of two iStent inject devices...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27881591/vernal-keratoconjunctivitis-culmination-of-management-using-immunosuppression-surgical-and-prosthetic-therapy-over-quarter-century
#18
Shilpa Das, Anand S Pasari, Virender S Sangwan
A 22-year-old male patient presented in 1988 with active vernal keratoconjunctivitis. He was treated with topical mast cell stabilisers and corticosteroids. Chronic inflammation despite topical treatment necessitated oral immunosuppressants. Active disease came under control with this; however, the patient gradually developed limbal stem cell deficiency. He underwent bilateral pannus resection with amniotic membrane transplantation that resulted in improved ocular surface. In 2007, patient was found to have significant bilateral posterior subcapsular cataracts and underwent bilateral cataract surgery with intraocular lens implantation with good visual outcome...
November 23, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27878429/comparison-of-specular-microscopy-and-ultrasound-pachymetry-before-and-after-cataract-surgery
#19
Alberto López-Miguel, María Sanchidrián, Itziar Fernández, Alfredo Holgueras, Miguel J Maldonado
PURPOSE: To compare specular microscopy (Topcon SP-3000P, Topcon Corporation, Tokyo, Japan) and ultrasound (US) technology when evaluating central corneal thickness (CCT) prior to and after phacoemulsification. METHODS: Corneal edema was assessed in phacoemulsification patients due to senile cataract by measuring CCT preoperatively and 1 day, 1 month, and 3 months postoperatively. Bland-Altman analysis was performed to assess interchangeability between pachymetry techniques for each visit...
November 22, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27871542/severe-respiratory-depression-and-bradycardia-before-induction-of-anesthesia-and-onset-of-takotsubo-cardiomyopathy-after-cardiopulmonary-resuscitation
#20
Yuko Furuichi, Ayaka Hamada, Keiko Nakazato, Katsuya Kobayashi, Atsuhiro Sakamoto
A 69-year-old woman undergoing treatment for hypertension and epilepsy was scheduled to undergo cataract surgery. All preoperative examination results were within normal limits. Despite being tense, she walked to the operating room. Approximately 2 minutes after an intravenous line was established by an anesthesia resident, severe hypoxia and bradycardia developed, and she lost consciousness. Cardiopulmonary resuscitation was initiated immediately, and after 1 minute, she regained consciousness, and her breathing and circulation recovered...
December 2016: Journal of Clinical Anesthesia
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