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Blepharitis

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https://www.readbyqxmd.com/read/27896297/a-mouse-model-of-multi-drug-resistant-staphylococcus-aureus-induced-ocular-disease
#1
Nicole M Broekema, Inna V Larsen, Erika S Naruzawa, Marcin Filutowicz, Aaron W Kolb, Leandro B C Teixeira, Curtis R Brandt
Staphylococcus aureus infection of the cornea is a significant threat to vision. The percentage of bacterial isolates resistant to antibiotics is increasing as is the percentage of infections caused by methicillin resistant isolates. There is a critical need for additional therapeutic approaches and their development will require the use of animal models to test efficacy. Two mouse models of S. aureus keratitis have been described but only quantified stromal keratitis (corneal clouding and perforation). We have extended these models using the methicillin resistant S...
November 2016: Journal of Ocular Biology
https://www.readbyqxmd.com/read/27817918/a-randomized-double-masked-placebo-controlled-clinical-trial-of-two-forms-of-omega-3-supplements-for-treating-dry-eye-disease
#2
Laura A Deinema, Algis J Vingrys, Chinn Yi Wong, David C Jackson, Holly R Chinnery, Laura E Downie
PURPOSE: To assess the efficacy of 2 forms of oral long-chain omega-3 (ω-3) essential fatty acid (EFA) supplements, phospholipid (krill oil) and triacylglyceride (fish oil), for treating dry eye disease (DED). DESIGN: Randomized, double-masked, placebo-controlled clinical trial. PARTICIPANTS: This study was conducted at a single site and involved 60 participants with mild to moderate DED who were randomized (1:1:1) to 1 of 3 groups: placebo (olive oil), krill oil, or fish oil supplements...
November 3, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27815679/-treatment-options-for-chronic-blepharitis-considering-current-evidence
#3
C Auw-Hädrich, T Reinhard
The goal of the treatment of chronic blepharitis lies in the reduction of inflammation, which can be achieved by warming, mechanical, and immunomodulatory measures as well as acaricide medication in cases with pathogenetically relevant demodicosis.
November 4, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27800249/clinical-findings-follow-up-and-treatment-results-in-patients-with-ocular-rosacea
#4
İlkay Kılıç Müftüoğlu, Yonca Aydın Akova
OBJECTIVES: To report the clinical features, treatment options and complications in patients with ocular rosacea. MATERIALS AND METHODS: The records of 48 eyes of 24 patients with ocular rosacea were retrospectively reviewed. Patients' ocular signs and symptoms were scored between 1 and 4 points according to disease severity; tear film break-up time (BUT) and Schirmer's test results were recorded before and after the treatment. Preservative-free artificial tears, topical antibiotic eye drops/ointments, short-term topical corticosteroids, topical 0...
January 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27791408/evaluation-of-meibomian-gland-dysfunction-in-polycystic-ovary-syndrome-and-obesity
#5
Gonen Baser, Nurdan Yildiz, Mehmet Calan
: Purpose/Aim of the study: The purpose of this study was to evaluate the interaction between Polycystic ovary syndrome (PCOS) and Meibomian gland dysfunction (MGD) and obesity, to reveal whether there is a correlation between the testosterone levels and body-mass index (BMI) levels and the dry-eye complaints of these patients. MATERIAL AND METHODS: The study included 92 patients with PCOS and 52 healthy patients from March 2013 to March 2014. All patients underwent a physical examination, pelvic ultrasound, and clinical and biochemical tests, including free testosterone levels to confirm the diagnosis of PCOS...
October 28, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27775234/sterile-corneal-infiltrates-after-corneal-collagen-cross-linking-evaluation-of-risk-factors
#6
Eren Çerman, Deniz Özarslan Özcan, Ebru Toker
PURPOSE: To evaluate possible risk factors leading to sterile corneal infiltrates following corneal collagen cross-linking (CXL). METHODS: A total of 588 eyes of 459 patients treated with Epi-off (n = 461) or Epi-on (n = 127) CXL were retrospectively evaluated. Risk factors, including preoperative blepharitis and vernal conjunctivitis, the postoperative use of topical non-steroidal anti-inflammatory drugs (NSAIDs), as well as Kmax and pachymetry measurements, were assessed...
October 24, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27774903/sulfur-mustard-induced-ocular-injuries-update-on-mechanisms-and-management
#7
Yunes Panahi, Danial Roshandel, Mohammad Mehdi Sadoughi, Mostafa Ghanei, Amirhossein Sahebkar
Sulfur mustard (SM; mustard gas) is a classic chemical warfare agent that has been used in several wars and is still a potential threat especially in the Middle-East region. Victims experience acute symptoms in air-exposed organs including skin, respiratory tract and the eyes. Survivors of the acute stage might develop chronic or delayed-onset complications in the exposed organs. The exact mechanism(s) of SM-induced tissue damage is still unknown, however DNA alkylation and oxidative damage are the most relevant mechanisms...
October 21, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27621301/recurrent-fungal-keratitis-and-blepharitis-caused-by-aspergillus-flavus
#8
Chia-Yi Lee, Yi-Ju Ho, Chi-Chin Sun, Hsin-Chiung Lin, Ching-Hsi Hsiao, David Hui-Kang Ma, Chi-Chun Lai, Hung-Chi Chen
Aspergillus species produces a wide spectrum of fungal diseases like endophthalmitis and fungal keratitis ophthalmologically, but there has been no report about blepharitis caused by Aspergilus flavus to date. Herein, we report a 61-year-old ethnic Han Taiwanese male who had suffered from pain with burning and foreign body sensation after an insect bite on his left eye. Specimens from bilateral eyelids suggested infection of A. flavus, whereas corneal scraping showed the presence of Gram-negative bacteria. He was admitted for treatment of infectious keratitis with topical antibiotic and antifungal eye drops...
November 2, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27617811/tick-infestation-of-the-eyelid-and-removal-with-forceps-and-punch-biopsy
#9
Jongyeop Park, Eoksoo Suh
Ocular tick infestation can occur in any age group or sex with exposure in an endemic setting. All parts of the ocular tissue have been reported to be susceptible to tick infestation. The authors present a rare patient with tick infestation of eyelid.An 88-year-old woman was referred for a yellowish lesion of the right upper eyelid. She had a history of sting 2 days before presentation, and developed eyelid swelling with mucopurulent discharge the next day. Slit lamp examination showed blepharitis and revealed that the lesion was the body of a hard tick, firmly attached to eyelid...
September 9, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27595013/how-important-is-the-etiology-in-the-treatment-of-epiphora
#10
Mahmut Oğuz Ulusoy, Sertaç Argun Kıvanç, Mehmet Atakan, Berna Akova-Budak
Purpose. There are several etiological factors that cause epiphora, and treatment differs according to the cause. We aimed to evaluate the etiology of epiphora and the treatment modalities of the affected patients. Materials and Methods. Data of patients who were referred to ophthalmology clinics for epiphora were retrospectively analyzed. All patients were evaluated for epiphora etiology, treatment modalities, and duration of complaints, after complete ophthalmologic examination. Results. This study consisted of 163 patients with a mean age of 64...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27570444/a-randomized-double-masked-parallel-group-comparative-study-to-evaluate-the-clinical-efficacy-and-safety-of-1-azithromycin-0-1-dexamethasone-combination-compared-to-1-azithromycin-alone-0-1-dexamethasone-alone-and-vehicle-in-the-treatment-of-subjects-with-blepharitis
#11
Kamran Hosseini, Richard L Lindstrom, Gary Foulks, Kelly K Nichols
PURPOSE: To evaluate the clinical efficacy and safety of a 1% azithromycin-0.1% dexamethasone combination in DuraSite ("combination") compared to 0.1% dexamethasone in DuraSite, 1% azithromycin in DuraSite, and vehicle in the treatment of subjects with blepharitis. MATERIALS AND METHODS: This was a Phase III, double-masked, vehicle-controlled, four-arm study in which 907 subjects with blepharitis were randomized to combination (n=305), 0.1% dexamethasone (n=298), 1% azithromycin (n=155), or vehicle (n=149)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27556267/oral-administration-of-famciclovir-for-treatment-of-spontaneous-ocular-respiratory-or-dermatologic-disease-attributed-to-feline-herpesvirus-type-1-59-cases-2006-2013
#12
Sara M Thomasy, Olivia Shull, Catherine A Outerbridge, Christine C Lim, Kate S Freeman, Ann R Strom, Philip H Kass, David J Maggs
OBJECTIVE To evaluate outcomes for cats treated with orally administered famciclovir 3 times/d for clinical signs attributed to naturally occurring feline herpesvirus type 1 (FHV-1) infection and to assess variables related to owner satisfaction with the treatment. DESIGN Retrospective case series. ANIMALS 59 client-owned cats. PROCEDURES Medical records were reviewed to identify cats treated for presumed FHV-1 infection from 2006 through 2013 with ≥ 1 follow-up visit. Signalment, duration of clinical signs, prior treatment, examination findings, diagnostic test results, concurrent treatments, and outcome data were recorded...
September 1, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27538858/demodex-musculi-infestation-in-genetically-immunomodulated-mice
#13
Peter C Smith, Caroline J Zeiss, Amanda P Beck, Jodi A Scholz
Demodex musculi, a prostigmatid mite that has been reported infrequently in laboratory mice, has been identified with increasing frequency in contemporary colonies of immunodeficient mice. Here we describe 2 episodes of D. musculi infestation with associated clinical signs in various genetically engineered mouse strains, as well as treatment strategies and an investigation into transmissibility and host susceptibility. The first case involved D. musculi associated with clinical signs and pathologic lesions in BALB/c-Tg(DO11...
2016: Comparative Medicine
https://www.readbyqxmd.com/read/27500111/comparison-of-therapeutic-effects-of-topical-azithromycin-solution-and-systemic-doxycycline-on-posterior-blepharitis
#14
Mehdi Zandian, Neda Rahimian, Sanaz Soheilifar
AIM: To compare the effect of azithromycin drop and doxycycline capsule on treatment of posterior blepharitis. METHODS: Fifty patients (100 eyes) with moderate posterior blepharitis, randomly divided into two therapeutic groups; all the patients got warm eyelid compress and massage three times a day for 3wk. In addition the first group got azithromycin 1% drop, twice daily for 1wk and then one drop daily for 2wk. The second group got oral doxycycline 100 mg daily for 3wk...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27498656/successful-treatment-of-a-chronic-eczema-in-a-48-year-old-female-with-dr-michaels%C3%A2-eczitinex%C3%A2-and-itchinex%C3%A2-product-family-a-case-report
#15
M Tirant, P Anderson, P Bayer, J Hercogovấ, M Fioranelli, S Gianfaldoni, A A Chokoeva, G Tchernev, U Wollina, F Novotny, M G Roccia, G K Maximov, K França, T Lotti
We report the case of a 48-year-old female with chronic atopic eczema who responded successfully to Dr Michaels® (Eczitinex® and Itchinex®) product family. The patient had a 41-year history of atopic eczema and presented with erythematous, excoriated lesions with telangiectasia and scattered purpura (bruising) covering 90% of her body surface area. The patient also regularly suffered blepharitis with red, itchy, watery eyes. The patient was treated with Dr Michaels® (Eczitinex® and Itchinex®) ointment and herbal supplements and presented total resolution of the atopic eczema and underlying inflammation within 6 weeks...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27492380/prospective-observational-post-marketing-study-of-tafluprost-0-0015-timolol-0-5-combination-ophthalmic-solution-for-glaucoma-and-ocular-hypertension-short-term-efficacy-and-safety
#16
Yasutaka Takagi, Hirotaka Osaki, Tomohiro Yamashita, Yasuhiko Kai
INTRODUCTION: The intraocular pressure (IOP)-lowering effect and safety of tafluprost 0.0015%/timolol maleate 0.5% combination ophthalmic solution (Taf-TFC) were investigated in a real-world clinical setting. METHODS: A prospective up to 2-year (more than 1 year) observational study has been initiated to collect data on the IOP, conjunctival hyperemia score, corneal staining score, and adverse events suffered by patients with glaucoma or ocular hypertension treated at 3 months, and up to 2 years (more than 1 year) after initiating treatment with Taf-TFC...
August 4, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27490319/functional-and-morphologic-changes-of-meibomian-glands-in-an-asymptomatic-adult-population
#17
Nisha S Yeotikar, Hua Zhu, Maria Markoulli, Kelly K Nichols, Thomas Naduvilath, Eric B Papas
PURPOSE: The aim of the study was to understand natural changes of meibomian glands (MG) that occur with aging in the absence of any ocular pathology or ocular discomfort symptoms, to differentiate between "age normal" and pathologic or dysfunctional changes of the MG. METHODS: A total of 185 subjects (109 females) with no pre-existing ocular and systemic abnormalities were recruited and divided into four age groups: 25 to 34, 35 to 44, 45 to 54, and 55 to 66 years...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27473509/ocular-surface-microbiome-in-meibomian-gland-dysfunction-in-auckland-new-zealand
#18
Grant A Watters, Philip R Turnbull, Simon Swift, Alex Petty, Jennifer P Craig
BACKGROUND: To investigate the ocular microbiome in meibomian gland dysfunction (MGD) relative to the normal eye in Auckland, New Zealand (NZ). DESIGN: Prospective, cross-sectional, observational study in a University setting. PARTICIPANTS: A total of 157 participants, resident in NZ for ≥ 2 years were classified as normal (n = 66), mild MGD (n = 41), and moderate-to-severe MGD (n = 50). Contact lens (CL) wear and anterior blepharitis status were recorded, as well as symptoms and clinical features...
July 29, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27468097/-blepharitis-when-to-perform-surgery
#19
M C Herwig, K U Löffler
AIM: Meibomian gland dysfunction/blepharitis is usually a harmless inflammatory process of the lid margin. However, it can be the first sign of a malignant lesion. Patients/Results: Clinical and histological findings are illustrated for 8 patients with changes in the lid margin and with the differential diagnosis of blepharitis. CONCLUSION: Tumours of the lid margin can mimic blepharitis or induce meibomian gland dysfunction. Conversely, blepharitis can present in a nodular form, which is highly indicative of a neoplasm...
July 2016: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27462249/therapeutical-management-for-ocular-rosacea
#20
Gloria López-Valverde, Elena Garcia-Martin, José Manuel Larrosa-Povés, Vicente Polo-Llorens, Luis E Pablo-Júlvez
PURPOSE: The purpose of this study is to describe a case of ocular rosacea with a very complex evolution. Rosacea is a chronic dermatological disease that may affect the ocular structures up to 6-72% of all cases. This form is often misdiagnosed, which may lead to long inflammatory processes with important visual consequences for affected patients. Therefore, an early diagnosis and an adequate treatment are important. METHODS: We report the case of a 43-year-old patient who had several relapses of what seemed an episode of acute bacterial conjunctivitis...
January 2016: Case Reports in Ophthalmology
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