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https://www.readbyqxmd.com/read/29136266/prostanoids-and-hair-follicles-implications-for-therapy-of-hair-disorders
#1
Xue-Gang Xu, Hong-Duo Chen
Prostanoids, including prostaglandins (PGs) and thromboxane A2 (TXA2), are a family of lipid-derived autacoids that modulate many physiological systems and pathological contexts. Prostanoids are generated by sequential metabolism of arachidonic acid, catalysed by cyclo-oxygenase, to PGH2, which is then converted to PGD2, PGE2, PGF2α, PGI2 and TXA2, catalysed by their specific synthases. Recent evidence suggests that prostanoids play a role in regulating hair growth. The PGF2α analogue is Food and Drug Administration-approved and routinely used to enhance the growth of human eyelashes...
November 14, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29046359/androgens-trigger-different-growth-responses-in-genetically-identical-human-hair-follicles-in-organ-culture-that-reflect-their-epigenetic-diversity-in-life
#2
Benjamin H Miranda, Matthew R Charlesworth, Desmond J Tobin, David T Sharpe, Valerie A Randall
Male sex hormones-androgens-regulate male physique development. Without androgen signaling, genetic males appear female. During puberty, increasing androgens harness the hair follicle's unique regenerative ability to replace many tiny vellus hairs with larger, darker terminal hairs (e.g., beard). Follicle response is epigenetically varied: some remain unaffected (e.g., eyelashes) or are inhibited, causing balding. How sex steroid hormones alter such developmental processes is unclear, despite high incidences of hormone-driven cancer, hirsutism, and alopecia...
October 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29023521/factors-affecting-eye-drop-instillation-in-glaucoma-patients-with-visual-field-defect
#3
MULTICENTER STUDY
Tomoko Naito, Koji Namiguchi, Keiji Yoshikawa, Kazuhisa Miyamoto, Shiro Mizoue, Yoichi Kawashima, Atushi Shiraishi, Fumio Shiraga
BACKGROUND: To investigate the success rate of eye drop instillation in glaucoma patients with visual field defect as well as non-glaucoma volunteers. Factors that may affect the success rate of eye drop instillation were also evaluated. DESIGN: A prospective, observational study. PARTICIPANTS: Seventy-eight glaucoma patients and 85 non-glaucoma volunteers were recruited in this study. METHODS: Open angle glaucoma patients with visual field defect as well as non-glaucoma volunteers were asked to video record their procedures of eye drop instillation using a 5-mL plastic bottle of artificial tear solution...
2017: PloS One
https://www.readbyqxmd.com/read/28986312/bilateral-upper-and-lower-eyelid-margin-swelling-and-madarosis-due-to-lymphoma
#4
Huy V Nguyen, Frederick A Jakobiec, Fouad R Zakka, Michael K Yoon
Over a 2 year period a 32-year-old woman developed swellings of all 4 eyelid margins accompanied by complete loss of eyelashes. An inflammatory dermatologic condition was considered the most likely cause. A full thickness right lower eyelid biopsy revealed a multinodular lymphoid tumor at the eyelid margin which immunophenotypically and genetically was diagnosed as an extranodal marginal zone lymphoma. The mode of presentation of the disease was considered to be most unusual, as was its B cell lineage, since the majority of primary cutaneous lymphomas are of T-cell origin...
October 3, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28984213/-superglue-instead-of-eye-ointment-the-sealed-eye-often-frightening-and-painful-generally-ends-well
#5
R H C Zegers
BACKGROUND: Not infrequently, patients mistakenly put glue in their eye. This often induces considerable emotional and physical reaction. CASE DESCRIPTION: A 20-year-old man came to the Emergency Department at night because he had mistaken a tube of superglue for his eye ointment and instilled the glue into his right eye. All the glue was removed, as were most of his eyelashes. The glue-induced corneal abrasion healed completely and the patient did not sustain any permanent injury...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28954106/trichotillomania-a-good-response-to-treatment-with-n-acetylcysteine
#6
Livia Ariane Lopes Barroso, Flavia Sternberg, Maria Natalia Inacio de Fraia E Souza, Gisele Jacobino de Barros Nunes
Trichotillomania is considered a behavioral disorder and is characterized by the recurring habit of pulling one's hair, resulting in secondary alopecia. It affects 1% of the adult population, and 2 to 4.4% of psychiatric patients meet the diagnostic criteria. It can occur at any age and is more prevalent in adolescents and females. Its occurrence in childhood is not uncommon and tends to have a more favorable clinical course. The scalp, eyebrows and eyelashes are the most commonly affected sites. Glutamate modulating agents, such as N-acetylcysteine, have been shown to be a promising treatment...
July 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28953300/eyelash-caring-between-the-lines
#7
Alexis Drutchas
No abstract text is available yet for this article.
September 2017: Family Medicine
https://www.readbyqxmd.com/read/28945649/short-term-comfort-responses-associated-with-the-use-of-eyelid-cleansing-products-to-manage-demodex-folliculorum
#8
William Ngo, Lyndon Jones, Etty Bitton
PURPOSE: To quantify the discomfort over time of various eyelid cleansers against Demodex. METHODS: This was a prospective, randomized, controlled, crossover, open-label study that enrolled 26 participants. The cleansers used in this study were Biotissue Cliradex (CD), OCuSOFT Lid Scrubs Plus (OP), OCuSOFT OUST Demodex Swabstix (ODS), TheraTears Theralid (TT), NovaBay Avenova (NA). Bausch+Lomb Sensitive Eyes Plus saline was used as a control. Participants were asked to close their eyes as the product was gently rubbed (10 cycles of gentle lateral motion) into the eyelashes...
September 21, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28944579/morphological-criteria-of-feminine-upper-eyelashes-quantified-by-a-new-semi-automatized-image-analysis-application-to-the-objective-assessment-of-mascaras
#9
A Shaiek, F Flament, G François, M Vicic, S Cointereau-Chardron, E Curval, S Canevet-Zaida, O Coubard, Y Idelcaid
BACKGROUND: The wide diversity of feminine eyelashes in shape, length, and curvature makes it a complex domain that remains to be quantified in vivo, together with their changes brought by application of mascaras that are visually assessed by women themselves or make-up experts. METHODS: A dedicated software was developed to semi-automatically extract and quantify, from digital images (frontal and lateral pictures), the major parameters of feminine eyelashes of Mexican and Caucasian women and to record the changes brought by the applications of various mascaras and their brushes, being self or professionally applied...
September 24, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28900819/a-homozygous-pigo-mutation-associated-with-severe-infantile-epileptic-encephalopathy-and-corpus-callosum-hypoplasia-but-normal-alkaline-phosphatase-levels
#10
Yoav Zehavi, Anja von Renesse, Etty Daniel-Spiegel, Yonatan Sapir, Luci Zalman, Ilana Chervinsky, Markus Schuelke, Rachel Straussberg, Ronen Spiegel
We describe two sisters from a consanguineous Arab family with global developmental delay, dystrophy, axial hypotonia, epileptic encephalopathy dominated by intractable complex partial seizures that were resistant to various anti-epileptic treatments. Dysmorphic features comprised low set ears, hypertelorism, upslanting palpebral fissures, a broad nasal bridge, and blue sclera with elongated eyelashes. Brain MRI in both children showed a corpus callosum hypoplasia that was evident already in utero and evolving cortical atrophy...
December 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28887006/a-3-month-safety-and-efficacy-study-of-travoprost-0-004-ophthalmic-solution-compared-with-timolol-in-pediatric-patients-with-glaucoma-or-ocular-hypertension
#11
El Roy Dixon, Theresa Landry, Subha Venkataraman, Nancy Gustafson, Craig Salem, Yasmin Bradfield, Leyla Ali Aljasim, Robert Feldman
PURPOSE: To evaluate efficacy and safety of travoprost in pediatric patients with ocular hypertension or glaucoma and demonstrate its noninferiority to timolol. METHODS: Patients aged 2 months to <18 years with glaucoma or ocular hypertension were randomized to receive travoprost (0.004%) or timolol eye drops (0.25% for patients aged 2 months to <3 years and 0.5% for patients ≥3 years old) for 3 months in this double-masked, parallel-group study. Intraocular pressure (IOP) was measured and patients were evaluated at 2 weeks, 6 weeks, and 3 months after treatment...
September 6, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28884914/white-eyelashes-and-red-eyes-in-a-7-year-old-boy
#12
Isabella Plumptre, Satyamaanasa Polubothu, Dhanes Thomas, Veronica Kinsler
No abstract text is available yet for this article.
September 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28880899/effects-of-sedation-on-subjective-perception-of-pain-intensity-and-autonomic-nervous-responses-to-pain-a-preliminary-study
#13
RANDOMIZED CONTROLLED TRIAL
Hongling Kang, Aya Nakae, Hiroshi Ito, Piyasak Vitayaburananont, Takehiro Minamoto, Takashi Ikeda, Mariko Osaka, Takashi Mashimo, Yuji Fujino, Satoshi Hagihira
Rather than relying solely on subjective pain evaluation using means such as the visual analogue scale (VAS), in clinical situations it is possible to observe evoked responses of the autonomic nervous system (ANS) as objective indicators. Few studies, however, have reported these relationships under finely controlled sedation. 16 healthy male participants were administrated in intravenous sedation with either propofol or midazolam randomly. We initially determined, using pharmacokinetic simulation, the effect-site concentration (Ce) of anaesthetic at loss of response to verbal command and eyelash reflex (Ce-LOR)...
2017: PloS One
https://www.readbyqxmd.com/read/28878839/a-case-report-of-9p-deletion-syndrome-associated-with-partial-trisomy-of-1q42
#14
Ali Vahabi, Filiz Hazan, Isa Abdi Rad
We report a case of partial deletion of 9p with partial trisomy of 1q42 syndrome, which is a rare clinical and cytogenetic report. The dysmorphic features of the patient include microcephaly, plagiocephaly, trigonocephaly with metopic ridge, arched eyebrows, hypertelorism, down-slanting palpebral fissure, ptosis, blepharophimosis, unilateral left epicanthic fold, long eyelashes, low-set and posteriorly rotated ears, long philtrum, anteverted nares, retrognathia and unilateral undescended testis. Chromosomal analysis revealed partial monosomy of 9p24 associated with partial trisomy of 1q42q>ter...
January 2017: Mædica
https://www.readbyqxmd.com/read/28871934/diffuse-palmoplantar-keratoderma-onychodystrophy-universal-hypotrichosis-and-cysts
#15
Tasleem Arif, Syed Suhail Amin, Mohammad Adil, Mohd Mohtashim
Dear Editor, Clouston syndrome, also called hidrotic ectodermal dysplasia (HED), is an autosomal dominant ectodermal dysplasia characterized by a clinical triad of onychodystrophy, generalized hypotrichosis, and palmoplantar keratoderma (1). Herein we report the case of a 24-year-old male with the distinctive clinical triad associated with multiple epidermoid cysts, which probably reflects the phenotype of Clouston syndrome. A 24-year-old male presented to our Department with diffuse thickening of the skin of his palms and soles since infancy...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28864923/evaluation-of-carbon-dioxide-laser-therapy-for-benign-tumors-of-the-eyelid-margin
#16
Aniko Rentka, Jan Grygar, Zoltan Nemes, Adam Kemeny-Beke
Eyelid margin tumors require special attention based on both anatomical and histological perspectives. Our aim in this study was to evaluate carbon dioxide (CO2) laser therapy for the treatment of eyelid margin tumors. Fifty-two patients with 55 eyelid margin tumors were included in this study. All tumors were removed with a CO2 laser, and histopathological evaluation was obtained in 52 cases. All patients were followed up for a mean period of 8.5 months (range 6 to 14 months). There were no bleedings in the intra- and postoperative period; the wounds were dry and reepithelized after 10-14 days and no recurrence occurred during follow-up period...
November 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28860926/getting-hooked-eyelash-in-lacrimal-punctum
#17
Swati Singh, Purvasha Narang, Vikas Mittal
No abstract text is available yet for this article.
July 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28839394/eyelash-trichomegaly-a-rare-presenting-feature-of-systemic-lupus-erythematosus
#18
Ashish Dalal, Sudhanshu Sharma, Ajay Kumar, Nidhi Sharma
An increase in length, curling, pigmentation, or thickness of eyelashes is termed eyelash trichomegaly. It may be inherited as an isolated trait or as a feature of a congenital syndrome such as Oliver-McFarlane syndrome or oculocutaneous albinism. Acquired conditions associated with eyelash trichomegaly include HIV infection, connective tissue disorders, and the administration of drugs such as cyclosporine and topical latanoprost. We hereby report a rare case of acquired eyelash trichomegaly with diffuse hair loss and "lupus hairs" on the scalp in a 16-year-old female diagnosed with systemic lupus erythematosus...
April 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28831569/madarosis-a-qualitative-study-to-assess-perceptions-and-experience-of-australian-patients-with-early-breast-cancer-treated-with-taxane-based-chemotherapy
#19
K Smith, J Winstanley, F Boyle, A O'Reilly, M White, Y C Antill
PURPOSE: Eyebrow and eyelash loss (madarosis) is a common and distressing side effect of chemotherapy for which no protective strategies have yet been developed. The purpose of this study was to develop an overview of perceptions and experiences of women undergoing taxane-based treatment for early breast cancer. METHODS: A total of 25 women with a diagnosis of invasive early breast cancer participated in a focus group (n = 5), ages ranging from 35 to 64 (median 50), all had completed therapy with a taxane-based chemotherapy treatment...
August 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28744094/patient-considerations-in-ocular-hypertension-role-of-bimatoprost-ophthalmic-solution
#20
REVIEW
Daniel Lee, Anand V Mantravadi, Jonathan S Myers
Glaucoma is a leading cause of irreversible blindness worldwide. The reduction of intraocular pressure has been well established as an effective treatment to prevent both the development and the progression of all forms of glaucoma. Bimatoprost 0.03% ophthalmic solution, introduced in 2001, is a synthetic prostamide with the unique mechanism of improving both uveoscleral and trabecular outflow. Comparative studies with other pharmacotherapies have shown favorable results for bimatoprost as a potent ocular hypotensive agent that is generally well tolerated...
2017: Clinical Ophthalmology
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