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clinical guideline thyroid cancer

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https://www.readbyqxmd.com/read/27899191/genetic-predisposition-to-endocrine-tumors-diagnosis-surveillance-and-challenges-in-care
#1
REVIEW
Elisabeth Joye Petr, Tobias Else
Endocrine tumor syndromes, eg, multiple endocrine neoplasia types 1 and 2, were among the first recognized hereditary predisposition syndromes to tumor development. Over time, the number of endocrine tumor syndromes has significantly expanded, eg, with the recent inclusion of hereditary paraganglioma syndromes. Associations of non-endocrine tumors with hereditary endocrine tumor syndromes and endocrine tumors with non-classical endocrine tumor syndromes have emerged. These findings have certainly expanded the scope of care, necessitating a multidisciplinary approach by a team of medical professionals and researchers, integrating shared patient decision-making at every step of surveillance, diagnosis, and treatment...
October 2016: Seminars in Oncology
https://www.readbyqxmd.com/read/27896825/is-it-time-to-reconsider-lobectomy-in-low-risk-paediatric-thyroid-cancer
#2
Wouter P Kluijfhout, Jesse D Pasternak, Danielle van der Kaay, Menno R Vriens, Evan J Propst, Jonathan D Wasserman
OBJECTIVE: Current guidelines recommend total thyroidectomy for nearly all children with well-differentiated thyroid cancer (WDTC). These guidelines, however, derive from older data accrued prior to current high-resolution imaging. We speculate that there is a sub-population of children who may be adequately treated with lobectomy. DESIGN: Retrospective analysis of prospectively maintained database. PATIENTS: 73 children with WDTC treated between 2004 and 2015...
November 29, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27896639/seom-clinical-guideline-for-bone-metastases-from-solid-tumours-2016
#3
C Grávalos, C Rodríguez, A Sabino, M Á Seguí, J A Virizuela, A Carmona, J Cassinello, D Isla, C Jara, M Martín
Bone metastases are common in many advanced solid tumours, being breast, prostate, thyroid, lung, and renal cancer the most prevalent. Bone metastases can produce skeletal-related events (SREs), defined as pathological fracture, spinal cord compression, need of bone irradiation or need of bone surgery, and hypercalcaemia. Patients with bone metastases experience pain, functional impairment and have a negative impact on their quality of life. Several imaging techniques are available for diagnosis of this disease...
December 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27858102/interleukin-10-expression-is-related-to-aggressiveness-and-poor-prognosis-of-patients-with-thyroid-cancer
#4
Lucas Leite Cunha, Elaine Cristina Morari, Sueli Nonogaki, Marjory Alana Marcello, Fernando Augusto Soares, José Vassallo, Laura Sterian Ward
Most patients with thyroid cancer will evolve very well with current therapies. However, 10-30% of these patients will present recurrent disease and some of them will eventually die. IL-10 is an anti-inflammatory and immunosuppressive cytokine that can contribute to the immune escape of neoplastic cells. We aimed to investigate IL-10 as a molecular marker to improve the clinical management of patients with thyroid cancer. We retrospectively studied 162 patients with follicular cell-derived thyroid cancer who attended to our institution, including 63 classic papillary thyroid carcinomas, 46 follicular variant of papillary thyroid carcinomas, 11 poorly differentiated thyroid carcinomas and 42 follicular thyroid carcinomas...
November 17, 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27843342/the-danish-head-and-neck-cancer-database
#5
REVIEW
Jens Overgaard, Aleksandar Jovanovic, Christian Godballe, Jesper Grau Eriksen
AIM OF THE DATABASE: The Danish Head and Neck Cancer database is a nationwide clinical quality database that contains prospective data collected since the early 1960s. The overall aim of this study was to describe the outcome of the national strategy for multidisciplinary treatment of head and neck cancer in Denmark and to create a basis for clinical trials. STUDY POPULATION: The study population consisted of all Danish patients referred for treatment of squamous cell carcinoma of the larynx, pharynx, oral cavity, or neck nodes from unknown primary or any histopathological type (except lymphoma) of cancer in the nasal sinuses, salivary glands, or thyroid gland (corresponding to the International Classification of Diseases, tenth revision, classifications C...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27804856/a-papillary-thyroid-carcinoma-in-pediatric-age-an-example-of-a-rare-tumour-managed-within-a-cooperative-comprehensive-project
#6
Claudio Spinelli, Maura Massimino, Giovanna Sironi, Andrea Ferrari, Marta Podda, Stefano Chiaravalli
Though rare in childhood, thyroid cancers represent the most frequent tumours of endocrine glands in childhood and adolescence. Papillary thyroid carcinoma is a non-medullary, follicular-derived differentiated tumour of the thyroid. There is still controversy concerning the therapeutic approach of PTCs in the paediatric population; regarding which should be the extent of the surgical approach, and the need for radioactive iodine (RAI) therapy. The cooperative TREP project (Tumori Rari in Età Pediatrica [Rare Tumours in Paediatric Age]) was launched in Italy in 2000 (under the patronage of AIEOP - Associazione Italiana Ematologia Oncologia Pediatrica) with a view to improving both research the clinical management on the less common paediatric cancers...
October 31, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27741354/2015-american-thyroid-association-management-guidelines-for-adult-patients-with-thyroid-nodules-and-differentiated-thyroid-cancer-what-is-new-and-what-has-changed
#7
Bryan R Haugen
Thyroid nodules are very common, and thyroid cancer is currently the fifth leading cancer diagnosis in women. The American Thyroid Association has led the development and revision of guidelines for the management of patients with thyroid nodules and differentiated thyroid cancer (DTC). The most current revision was published in the January 2016 issue of the journal Thyroid. The current guidelines have 101 recommendations, with 8 figures and 17 tables that are hopefully helpful to those treating patients with thyroid nodules and cancer...
October 14, 2016: Cancer
https://www.readbyqxmd.com/read/27644091/clinical-significance-of-prophylactic-central-compartment-neck-dissection-in-the-treatment-of-clinically-node-negative-papillary-thyroid-cancer-patients
#8
REVIEW
Claudio Gambardella, Ernesto Tartaglia, Anna Nunziata, Graziella Izzo, Giuseppe Siciliano, Fabio Cavallo, Claudio Mauriello, Salvatore Napolitano, Guglielmo Thomas, Domenico Testa, Gianluca Rossetti, Alessandro Sanguinetti, Nicola Avenia, Giovanni Conzo
BACKGROUND: Lymph nodal involvement is very common in differentiated thyroid cancer, and in addition, cervical lymph node micrometastases are observed in up to 80 % of papillary thyroid cancers. During the last decades, the role of routine central lymph node dissection (RCLD) in the treatment of papillary thyroid cancer (PTC) has been an object of research, and it is now still controversial. Nevertheless, many scientific societies and referral authors have definitely stated that even if in expert hands, RCLD is not associated to higher morbidity; it should be indicated only in selected cases...
September 19, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27623139/variability-of-serum-thyroglobulin-levels-in-post-thyroidectomy-patients-with-well-differentiated-thyroid-cancer-the-ata-guidelines
#9
Frieda Silva, Ralph J Martin, Jannette Figueroa, Fernando Rincón, Diego Román
OBJECTIVE: Evaluate the variability of stimulated serum thyroglobulin (Tg) levels in post-thyroidectomy patients with well-differentiated thyroid cancer (WDTC) and determine the frequency of undetectable Tg in patients with evidence of functional thyroid tissue after a 131-I whole-body scan (WBS). METHODS: A retrospective record review of patients with WDTC referred to our clinic from 1990 to 2010. Demographic data, histology, staging, imaging studies, stimulated Tg values, and the presence if applicable of Tg antibodies (TgAb) were documented...
September 2016: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/27607088/overview-of-the-2015-american-thyroid-association-guidelines-for-managing-thyroid-nodules-and-differentiated-thyroid-cancer
#10
Bashar Matti, Ruben Cohen-Hallaleh
The last few years have witnessed numerous publications addressing the management of thyroid nodules and differentiated thyroid cancers. The purpose of this review is to provide a simplified summary of the newly released guidelines by the American Thyroid Association. A systematic approach has been recommended to evaluate a thyroid nodule through clinical assessment, measurement of serum Thyroid Stimulating Hormone, neck ultrasonography and Fine Needle Aspiration where appropriate. This is followed by cytology analysis using the Bethesda scoring system to detect malignancy...
September 9, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27597378/extrathyroidal-extension-is-associated-with-compromised-survival-in-patients-with-thyroid-cancer
#11
Linda M Youngwirth, Mohamed A Adam, Randall P Scheri, Sanziana A Roman, Julie A Sosa
BACKGROUND: Patients with thyroid cancer who have extrathyroidal extension (ETE) are considered to have more advanced tumors. However, data on the impact of ETE on patient outcomes remain limited. The purpose of this study was to evaluate the association between ETE and survival in patients with thyroid cancer. METHODS: The National Cancer Database (1998-2012) was queried for all adult patients with differentiated thyroid cancer and medullary thyroid cancer. Patients were divided into three groups: no ETE (T1 and T2 tumors), minimal ETE (T3 tumors <4 cm), and extensive ETE (T4 tumors <4 cm)...
October 5, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27571216/thyroid-disorders-in-children-and-adolescents-a-review
#12
Patrick Hanley, Katherine Lord, Andrew J Bauer
Importance: Normal thyroid gland function is critical for early neurocognitive development, as well as for growth and development throughout childhood and adolescence. Thyroid disorders are common, and attention to physical examination findings, combined with selected laboratory and radiologic tools, aids in the early diagnosis and treatment. Objective: To provide a practical review of the presentation, evaluation, and treatment of thyroid disorders commonly encountered in a primary care practice...
October 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27549368/risk-of-malignancy-in-thyroid-nodules-with-non-diagnostic-fine-needle-aspiration-a-retrospective-cohort-study
#13
Ana E Espinosa De Ycaza, Kathleen M Lowe, Diana S Dean, M Regina Castro, Vahab Fatourechi, Mabel Ryder, John C Morris, Marius N Stan
BACKGROUND: Fine-needle aspiration (FNA) of thyroid nodules is commonly performed, and despite the use of ultrasound (US) guidance, the rate of non-diagnostic FNAs is still significant. The risk of malignancy of thyroid nodules with a non-diagnostic FNA is not clearly defined. However, most studies exclude the majority of patients without a repeat biopsy or surgery, thus increasing the likelihood of selection bias. The aims of this study were to determine the malignancy risk in nodules with an initial non-diagnostic FNA, and to identify the factors associated with malignancy...
November 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27540892/prognostic-factors-for-early-and-long-term-remission-in-pediatric-differentiated-thyroid-carcinoma-the-role-of-sex-age-clinical-presentation-and-the-newly-proposed-american-thyroid-association-risk-stratification-system
#14
Barbara Pereira Pires, Paulo Alonso Garcia Alves, Maria Alice Bordallo, Daniel Alves Bulzico, Flavia Paiva Proença Lobo Lopes, Terence Farias, Fernando Dias, Roberto Araújo Lima, Izabella Costa Santos Gisler, Claudia Medina Coeli, Raquel Vasconcellos Carvalhaes de Oliveira, Rossana Corbo, Mario Vaisman, Fernanda Vaisman
BACKGROUND: The incidence of pediatric differentiated thyroid carcinoma (DTC) has been rising in recent years, and the main risk factors for recurrence are lymph node and distant metastasis at diagnosis. Other clinical features remain unclear, such as the impact of age, sex, and puberty. Furthermore, until now, this population has been treated using the same strategies used to treat adults. In 2015, the American Thyroid Association (ATA) published the first guidelines targeted at this age group...
October 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27526430/-rarer-causes-of-thyrotoxicosis
#15
REVIEW
Robert Krysiak, Karolina Kowalcze, Bogusław Okopień
Thyrotoxicosis is a pathological syndrome in which tissue is exposed to excessive amounts of circulating thyroid hormones. Including its subclinical form, it is considered as one of the most frequent endocrine disorders in the general population. If not detected in a timely fashion, thyrotoxicosis can have serious health consequences. The most common forms of thyrotoxicosis include diffuse toxic goiter (Graves' disease), toxic multinodular goiter (Plummer's disease), and toxic adenoma (Goetsch's disease). The significant progress in the fields of hormonal assessment, imaging procedures and molecular biology made in recent years has brought about great improvement in the identification, differentiation and treatment of many other disorders associated with thyrotoxicosis...
2016: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/27469925/serial-thyroglobulin-variation-trend-shortly-after-radioiodine-therapy-in-poorly-to-moderately-differentiated-recurrent-thyroid-cancer
#16
(no author information available yet)
<strong>Objective </strong>To dynamically observe the early change of thyroglobulin(Tg) levels after (131)I therapy in differentiated thyroid cancer(DTC) patients. <strong>Methods </strong>The study enrolled 22 post-total-thyroidectomy DTC patients and they were stratified as low to intermediate recurrence according to the 2009 American Thyroid Association Guidelines. The clinical data including pre-ablation stimulated Tg (ps-Tg),corresponding thyroid stimulating hormone(TSH),anti-thyroglobulin (TgAb) values,and the afterwards parameters were dynamically measured each week in the first month after (131)I therapy...
June 10, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/27457090/usefulness-of-ultrasonography-is-the-evaluation-of-thyroid-nodules
#17
Carolina Franco Uliaque, Francisco Javier Pardo Berdún, Ricardo Laborda Herrero, Carmen Pérez Lórenz
OBJECTIVE: To evaluate the diagnostic capacity of ultrasonography (US) for differentiating between malignant and benign thyroid nodules and its usefulness in obviating unnecessary invasive procedures. PATIENTS AND METHODS: From January 2012 through December 2014, a total of 321 fine-needle aspiration biopsy (FNAB) procedures were done in 302 patients selected according to the criteria recommended by the American Association of Clinical Endocrinology guidelines and the American Thyroid Association guidelines...
September 2016: Radiología
https://www.readbyqxmd.com/read/27447700/national-trends-in-the-surgical-treatment-of-non-advanced-medullary-thyroid-cancer-mtc-an-evaluation-of-adherence-with-the-2009-american-thyroid-association-guidelines
#18
Eun Hae Estelle Chang, Waseem Lutfi, Joseph Feinglass, Alexandra Eudokia Reiher, Tricia Moo-Young, Mihir Kiran Bhayani
BACKGROUND: Medullary thyroid cancer (MTC) represents the third most common type of thyroid cancer, and the prognosis depends on the stage of the disease at diagnosis and completeness of tumor resection. In 2009, the American Thyroid Association (ATA) published guidelines with evidence-based recommendations for the treatment of MTC. This study aimed to determine national adherence rates of the treatment according to the ATA guidelines specific for MTC. METHODS: Patients diagnosed with MTC from 2004 to 2013 were identified from the National Cancer Database...
December 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27418023/the-changing-incidence-of-thyroid-cancer
#19
REVIEW
Cari M Kitahara, Julie A Sosa
During the past few decades, the incidence of thyroid cancer has increased substantially in many countries, including the USA. The rise in incidence seems to be attributable both to the growing use of diagnostic imaging and fine-needle aspiration biopsy, which has led to enhanced detection and diagnosis of subclinical thyroid cancers, and environmental factors. The latest American Thyroid Association (ATA) practice guidelines for the management of adult patients with thyroid nodules and differentiated thyroid cancer differ substantially from the previous ATA guidelines published in 2009...
November 2016: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/27412501/pediatric-thyroid-fna-biopsy-outcomes-and-impact-on-management-over-24-years-at-a-tertiary-care-center
#20
Elmira Amirazodi, Evan J Propst, Catherine T Chung, Dimitri A Parra, Jonathan D Wasserman
BACKGROUND: Thyroid malignancy is rare in young children, although the incidence increases sharply during adolescence. Nodular thyroid disease and thyroid cancer in children differ substantially from those in adults, because the rates of malignancy among children are roughly 5-fold higher, and local and distant metastases as well as recurrences are more common. Even with the recent introduction of pediatric guidelines, there remains a paucity of pediatric data on which to base clinical decision making...
November 2016: Cancer
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