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risk factor of periodontitis

Massimo Del Fabbro, Stefano Corbella, Patrick Sequeira-Byron, Igor Tsesis, Eyal Rosen, Alessandra Lolato, Silvio Taschieri
BACKGROUND: When primary root canal therapy fails, periapical lesions can be retreated with or without surgery. Root canal retreatment is a non-surgical procedure that involves removal of root canal filling materials from the tooth, followed by cleaning, shaping and obturating of the canals. Root-end resection is a surgical procedure that involves exposure of the periapical lesion through an osteotomy, surgical removal of the lesion, removal of part of the root-end tip, disinfection and, commonly, retrograde sealing or filling of the apical portion of the remaining root canal...
October 19, 2016: Cochrane Database of Systematic Reviews
E Darvishi, Z Aziziaram, K Yari, M Bagheri Dehbaghi, D Kahrizi, H Karim, S Vaziri, J Zargooshi, K Ghadiri, S Muhammadi, E Kazemi, M T Moradi, M Shokrinia, N Mohammadi
Periodontal disease is one of the most prevalent inflammatory illnesses and is a main cause of tooth loss in human population. Tumor necrosis factor-α (TNF-α) gene is one of pro-inflammatory cytokines which has important role in pathogenesis of periodontal disease. The main purpose of this study is to determine genotype abundance of TNF-α-1031 gene in both groups of patients and controls, and also investigation of relation of single nucleotide polymorphism (SNP) these genotypes with periodontal disease risk...
September 30, 2016: Cellular and Molecular Biology
Luigi Nibali, Anna Di Iorio, Yu-Kang Tu, Alexandre R Vieira
BACKGROUND: This study aimed to produce the latest summary of the evidence for association of host genetic variants contributing to both periodontitis and caries. MATERIALS AND METHODS: Two systematic searches of the literature were conducted in Ovid Medline, Embase, LILACS and Cochrane Library for large candidate gene studies, systematic reviews and GWAS reporting data on host genetic variants and presence of periodontal disease and caries. RESULTS: A total of 124 studies were included in the review (59 for the periodontitis outcome and 68 for the caries outcome), from an initial search of 15,487 titles...
October 18, 2016: Journal of Clinical Periodontology
Christian Walter, Bilal Al-Nawas, Tim Wolff, Eik Schiegnitz, Knut A Grötz
OBJECTIVE: Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is triggered by inflammatory processes. Typical trigger factors are periodontal disease, denture pressure sores, and surgical interventions such as tooth extractions. Unfortunately there is only little data on how to proceed with implant therapy in patients with bisphosphonate treatment. This topic is not addressed in the German guidelines on medication-associated osteonecrosis. Therefore a systematic literature review was performed...
December 2016: Int J Implant Dent
Fabien Cohen
This article reminds you that, whatever the psychoactive substance in question, it is not one that has repercussions on the oral health of its user. This affects both the tooth, the periodontal and oral mucosa. Drug addicts, especially those engaged in polydrug use, represent the population at the largest risk for oral cancer. Of all the factors, smoking is by far the largest risk. The alcohol has a synergistic effect with the tobacco, so that the combined effect is more than multiplied. Preventing risks of these products is possible through good oral hygiene and lifestyle, preventive care and followed by a regular dentist...
October 10, 2016: La Presse Médicale
Toyoko Morita, Yoji Yamazaki, Chika Fujiharu, Takanori Ishii, Misae Seto, Norihide Nishinoue, Yoshiyuki Sasaki, Kumiko Nakai, Hideki Tanaka, Takayuki Kawato, Masao Maeno
BACKGROUND: Epidemiological studies have reported that periodontitis and cardiometabolic disease such as cardiovascular disease and type 2 diabetes are associated; however, there have been very few prospective cohort studies on this topic. Therefore, we conducted a 9-year follow-up study to examine the relationship between the duration of periodontitis and cardiometabolic risk factors, including hypertension, hyperglycemia, dyslipidemia, and obesity. METHODS: The study participants comprised 572 adult industrial workers (417 men and 155 women; mean age, 37...
October 14, 2016: Metabolic Syndrome and related Disorders
Stephen K Harrel, Pillar Valderrama, James B Barnes, Evan L Blackwell
Small linear microgrooves have been observed on root surfaces associated with osseous defects when videoscope-assisted minimally invasive surgery (V-MIS) is performed. The aim of this study was to evaluate the frequency of occurrence of these microgrooves associated with osseous defects. Videos of dry skulls from an anatomy department collection and videos made during consecutive V-MIS procedures on patients were evaluated to determine the presence or absence of microgrooves associated with osseous defects...
November 2016: International Journal of Periodontics & Restorative Dentistry
Diego F Gualtero, Sergio M Viafara-Garcia, Sandra J Morantes, Diana M Buitrago, Octavio A Gonzalez, Gloria I Lafaurie
BACKGROUND: Rosuvastatin exhibits anti-inflammatory effects and reduces periodontal diseases and atherosclerosis; however, its role in regulating periodontopathogen-induced endothelial pro-inflammatory responses remains unclear. The purpose of this study was to determine whether rosuvastatin can reduce the pro-inflammatory response induced by A. actinomycetemcomitans in human coronary artery endothelial cells (HCAECs). METHODS: HCAECs were stimulated with purified A...
October 14, 2016: Journal of Periodontology
Suzely As Moimaz, Najara B Rocha, Artênio Ji Garbin, Cléa As Garbin, Orlando Saliba
This study evaluated the relationships between oral conditions and oral health-related quality of life (OHRQoL), as well as related factors. A crosssectional study was performed on 119 postnatal women who had sought prenatal care during pregnancy in the public health system of São Paulo State, Brazil. The women received oral clinical exams and were interviewed using the questions on the OHIP14. A second survey with information about their socioeconomic status, pregnancy and health habits was administered. The highest OHIP14 scores were found in the area of physical pain, with an average score of 10...
September 2016: Acta Odontológica Latinoamericana: AOL
Frederick Palm, Pirkko J Pussinen, Annette Aigner, Heiko Becher, Florian Buggle, Matthias F Bauer, Caspar Grond-Ginsbach, Anton Safer, Christian Urbanek, Armin J Grau
BACKGROUND AND AIMS: Infectious diseases contribute to stroke risk, and are associated with socioeconomic status (SES). We tested the hypotheses that the aggregate burden of infections increases the risk of ischemic stroke (IS) and partly explains the association between low SES and ischemic stroke. METHODS: In a case-control study with 470 ischemic stroke patients and 809 age- and sex-matched controls, randomly selected from the population, antibodies against the periodontal microbial agents Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, against Chlamydia pneumonia, Mycoplasma pneumoniae (IgA and IgG), and CagA-positive Helicobacter pylori (IgG) were assessed...
October 5, 2016: Atherosclerosis
Yorimasa Ogata, Yohei Nakayama, Junichi Tatsumi, Takehiko Kubota, Shuichi Sato, Tetsuya Nishida, Yasuo Takeuchi, Tokuya Onitsuka, Ryuji Sakagami, Takenori Nozaki, Shinya Murakami, Naritoshi Matsubara, Maki Tanaka, Toshiaki Yoshino, Junya Ota, Taneaki Nakagawa, Yuichi Ishihara, Taichi Ito, Atsushi Saito, Keiko Yamaki, Etsuko Matsuzaki, Toshirou Hidaka, Daisuke Sasaki, Takashi Yaegashi, Tadashi Yasuda, Toshiaki Shibutani, Kazuyuki Noguchi, Hisao Araki, Noriharu Ikumi, Yukihiko Aoyama, Hideki Kogai, Kenji Nemoto, Shinji Deguchi, Takashi Takiguchi, Matsuo Yamamoto, Keita Inokuchi, Takatoshi Ito, Takashi Kado, Yasushi Furuichi, Mikimoto Kanazashi, Kazuhiro Gomi, Yukie Takagi, Keita Kubokawa, Nobuo Yoshinari, Yoshiaki Hasegawa, Tetsushi Hirose, Toshinaga Sase, Hirokazu Arita, Toshiro Kodama, Kitetsu Shin, Yuichi Izumi, Hiromasa Yoshie
We investigated the prevalences and risk factors for peri-implant diseases in Japanese adult dental patients attending a follow-up visit at dental hospitals or clinics as part of their maintenance program. This cross-sectional multicenter study enrolled patients with dental implants who attended regular check-ups as part of a periodontal maintenance program during the period from October 2012 through September 2013. Patients with implants with at least 3 years of loading time were included in the study. The condition of peri-implant tissue was examined and classified into the following categories: healthy, peri-implant mucositis, and peri-implantitis...
October 7, 2016: Journal of Oral Science
Nozomi Okamoto, Masayuki Morikawa, Nobuko Amano, Motokazu Yanagi, Shin Takasawa, Norio Kurumatani
BACKGROUND: Several studies have suggested that periodontal disease can exacerbate the pro-inflammatory status of the brain. Tooth loss is one of the alternative evaluation indices of periodontal disease. There are few data on the relationship between tooth loss and memory impairment, depending on the apolipoprotein E (APOE) ɛ4 genotype. OBJECTIVE: To determine if tooth loss is associated with mild memory impairment (MMI) and if this association is modified by the presence of the APOEɛ4 allele...
October 1, 2016: Journal of Alzheimer's Disease: JAD
Ji-Young Joo, Gil Sun Cha, Jin Chung, Ju-Youn Lee, Sung-Jo Kim, Jeomil Choi
BACKGROUND: Although periodontal pathogens show a strong association with the development of atherosclerosis, little is known about how a microorganism contributes to disease onset and progression. Oxidation of low-density lipoprotein (LDL) is a major risk factor of atherogenesis. The principal objective of our study was to evaluate the ability of peptide 19 (Pep19) of Porphyromonas gingivalis (P. gingivalis) heat shock protein (HSP) as a potent inducer of LDL oxidation, and as a secondary objective, to compare this ability with that of Pep19 from different bacteria...
October 7, 2016: Journal of Periodontology
Chin-Wei Jeff Wang, Laurie K McCauley
Osteoporosis and periodontitis are both diseases characterized by bone resorption. Osteoporosis features systemic degenerative bone loss that leads to loss of skeletal cancellous microstructure and subsequent fracture, whereas periodontitis involves local inflammatory bone loss, following an infectious breach of the alveolar cortical bone, and it may result in tooth loss. Most cross-sectional studies have confirmed the association of osteoporosis and periodontitis primarily on radiographic measurements and to a lesser degree on clinical parameters...
September 30, 2016: Current Osteoporosis Reports
Yao-Tung Lee, Hsin-Chien Lee, Chaur-Jongh Hu, Li-Kai Huang, Shu-Ping Chao, Chia-Pei Lin, Emily Chia-Yu Su, Yi-Chen Lee, Chu-Chieh Chen
OBJECTIVES: To determine whether periodontitis is a modifiable risk factor for dementia. DESIGN: Prospective cohort study. SETTING: National Health Insurance Research Database in Taiwan. PARTICIPANTS: Individuals aged 65 and older with periodontitis (n = 3,028) and an age- and sex-matched control group (n = 3,028). MEASUREMENTS: Individuals with periodontitis were compared age- and sex-matched controls with for incidence density and hazard ratio (HR) of new-onset dementia...
September 29, 2016: Journal of the American Geriatrics Society
T G Kebede, B Holtfreter, T Kocher, P Meisel, T Dietrich, R Biffar, M Dörr, H Völzke, C Pink
Current evidence indicates the effects of periodontitis on diabetes as well as mortality, for which diabetes itself represents a risk factor. However, the possible interaction of these 2 chronic conditions regarding mortality has not yet been investigated. Therefore, the purpose of this study was to evaluate whether periodontal destruction interacts with diabetes on all-cause and cardiovascular disease (CVD) mortality or if diabetes serves as a mediator in this association. The study sample comprised 3,327 participants aged 20 to 81 y from the Study of Health in Pomerania...
September 28, 2016: Journal of Dental Research
K Agossa, A Dendooven, L Dubuquoy, C Gower-Rousseau, E Delcourt-Debruyne, M Capron
Inflammatory bowel disease and periodontitis are both described as a disproportionate mucosal inflammatory response to a microbial environment in susceptible patients. Moreover, these two conditions share major environmental and lifestyle-related risk factors. Despite this intriguing pathogenic parallel, large-scale studies and basic research have only recently considered periodontal outcomes as relevant data. There are mounting and consistent arguments, from recent epidemiologic studies and animal models, that these two conditions might be related...
September 24, 2016: Journal of Periodontal Research
Johannes C Ehrenthal, Christian Graetz, Anna Plaumann, Christof E Dörfer, Wolfgang Herzog
OBJECTIVE: Periodontal disease is associated with a wide range of psychosocial risk-factors. Disease-related tooth-loss has been associated with an increase in depressive symptoms in cross-sectional studies. However, while depression is a known risk-factor for the outcome of chronic diseases, it remains unclear if tooth loss can also predict depressive symptoms over the course of treatment. Aim of the current pilot study was to test, to what extend the number of teeth predict depressive symptoms several years later...
October 2016: Journal of Psychosomatic Research
Tan Firat Eyuboglu, Kezban Olcay, Mutlu Özcan
OBJECTIVES: This study assessed the outcome measures of single-visit root canal retreatments and frequency of periapical complications considering preoperative, intraoperative and postoperative factors. MATERIALS AND METHODS: Between November 2011 and December 2012, in 173 patients, a total of 234 endodontically treated teeth were retreated in a single appointment by one experienced endodontist. Five teeth were extracted and 119 teeth were lost to follow-up yielding to 110 teeth (47 %) to be examined by two calibrated examiners for the outcome of healing (periapical index score-PAI ≤2; no signs or symptoms) or non-healing (presence of apical periodontitis-PAI >2; signs or symptoms)...
September 22, 2016: Clinical Oral Investigations
Rodrigo Martin-Cabezas, Narendra Seelam, Catherine Petit, Kévimy Agossa, Sébastien Gaertner, Henri Tenenbaum, Jean-Luc Davideau, Olivier Huck
BACKGROUND: Several studies have shown that periodontal diseases are associated with hypertension (HT). However, heterogeneity among populations, diagnosis criteria, and shared risk factors represent some difficulties in terms of interpretation. Therefore, the aim of this study was to determine the magnitude of the association between periodontal diseases and HT. METHODS AND RESULTS: A systematic review and meta-analysis, including studies published up to June 2016, have been performed...
October 2016: American Heart Journal
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