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Antithyroid peroxidase

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https://www.readbyqxmd.com/read/29123489/plasmapheresis-responsive-rapid-onset-dementia-with-predominantly-frontal-dysfunction-in-the-context-of-hashimoto-s-encephalopathy
#1
Dominique Endres, Magnus S Vry, Petra Dykierek, Anne N Riering, Eva Lüngen, Oliver Stich, Rick Dersch, Nils Venhoff, Daniel Erny, Irina Mader, Philipp T Meyer, Ludger Tebartz van Elst
Background: Hashimoto's encephalopathy (HE) is a rare immunological neuropsychiatric disorder characterized by increased antithyroid antibodies and mixed neurological and psychiatric symptoms. HE has been previously discussed as a differential diagnosis for rapid progressive dementia. However, most of these patients suffered from additional neurological symptoms, like ataxia or seizures. Case presentation: Here, we present the case of a 59-year-old female patient suffering rapid onset dementia with salient frontal executive dysfunction...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29118518/insignificant-correlation-between-thyroid-hormone-and-antithyroid-peroxidase-antibodies-in-alopecia-areata-patients-in-northern-rajasthan
#2
Gagandeep Kaur, C M Kuldeep, Puneet Bhargava, Deepak Kumar Mathur, Sonam Sharda, Pulkit Chaturvedi
Background: Alopecia areata (AA) is a common, recurrent form of nonscarring alopecia which often presents as circumscribed patches of spontaneous hair loss. The global prevalence of this disease varies from 0.1% to 0.2% in general population and 7-30 cases per 1000 dermatological patients. The etiology of AA still remains uncertain; however, genetic or environmental factor and autoimmunity are claimed responsible for it. Various autoimmune diseases, such as Hashimoto's thyroiditis, diabetes mellitus, vitiligo, and lupus erythematosus, have been reported in association with AA...
October 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/29113356/prediction-of-thyroidal-131-i-effective-half-life-in-patients-with-graves-disease
#3
Ruiguo Zhang, Guizhi Zhang, Renfei Wang, Jian Tan, Yajing He, Zhaowei Meng
Purpose: Calculation of effective thyroidal half-life (Teff) of iodine-131((131)I) is cumbersome and tedious. The aim of this study was to investigate factors that could be used to predict Teff and to develop a Teff prediction model in Graves' disease patients. Methods: A total of 256 patients with GD were involved in this study. We investigated the influences of age, gender, disease duration, thyroid weight, antithyroid drugs, antithyroid drugs discontinuation period (ADP), thyroid function indexes, thyroid autoantibodies, thyroid-stimulating hormone receptor antibody (TRAb) level and radioactive iodine uptake (RAIU) values before (131)I therapy on Teff, applying univariate and multivariate analyses...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29102040/preconceptional-antithyroid-peroxidase-antibodies-but-not-thyroid-stimulating-hormone-are-associated-with-decreased-live-birth-rates-in-infertile-women
#4
Aimee Seungdamrong, Anne Z Steiner, Clarisa R Gracia, Richard S Legro, Michael P Diamond, Christos Coutifaris, William D Schlaff, Peter Casson, Gregory M Christman, Randal D Robinson, Hao Huang, Ruben Alvero, Karl R Hansen, Susan Jin, Esther Eisenberg, Heping Zhang, Nanette Santoro
OBJECTIVE: To study whether preconceptual thyroid-stimulating hormone (TSH) and antithyroid peroxidase (TPO) antibodies are associated with poor reproductive outcomes in infertile women. DESIGN: Secondary analysis of data from two multicenter, randomized, controlled trials conducted by the Reproductive Medicine Network of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Multivariable logistic regression analyses were performed to assess the association between preconceptual TSH levels and anti-TPO antibodies...
October 25, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29067268/prognostic-indicators-for-the-development-of-strabismus-among-patients-with-graves-ophthalmopathy
#5
Tiffany Y Lin, Ning Li, Michael W Yeh, Angela M Leung, Daniel B Rootman
OBJECTIVE: Thyroid eye disease (TED), an autoimmune inflammatory process involving the orbital tissues around the eye, is the most common extra-thyroidal manifestation of Graves' disease (GD). Due to changes in the patient's appearance, TED is a socially and visually disabling condition with significant impacts on quality of life. The aim of this study is to assess predictors of strabismus, a severe manifestation of TED. DESIGN: Single-institution retrospective case-control study...
September 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29042859/associations-between-systemic-sclerosis-and-thyroid-diseases
#6
REVIEW
Poupak Fallahi, Ilaria Ruffilli, Dilia Giuggioli, Michele Colaci, Silvia Martina Ferrari, Alessandro Antonelli, Clodoveo Ferri
We have reviewed scientific literature about the association of systemic sclerosis (SSc) and thyroid disorders. A high incidence, and prevalence, of new cases of autoimmune thyroiditis (AT) and/or hypothyroidism have been shown in sclerodermic patients (overall in the female gender). An association among a Th1 immune-predominance, low vitamin D levels, and AT have been also shown in SSc patients. Cases of Graves' disease (GD) have been described in SSc patients, too, according with the higher prevalence of thyroid autoimmunity...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28979761/visfatin-level-in-children-and-adolescents-with-autoimmune-thyroiditis
#7
Hekma Saad Farghaly, Kotb Abbass Metwalley, Faisal-Alkhateeb Ahmed, Duaa Mohamed Raafat, Osama El-Asheer, Ahmed Mahmood Ali, Ahlam Bahdawy, Asmaa Mohamed Zahran
BACKGROUND: This study aims to assess the levels of visfatin in children and adolescents with autoimmune thyroiditis (AIT) and its relationship with disease-related variables. METHODS: The study included 84 children and adolescents with AIT and 84 healthy subjects. Measurements of fasting glucose, insulin, thyroid-stimulating hormone (TSH), free thyroxin (FT4), antithyroid peroxidase antibodies (TPOAb) and antithyroglobulin antibody (TgAb) were completed, with assessment of visfatin levels...
August 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28904921/hashimoto-s-encephalitis-rare-manifestation-of-hypothyroidism
#8
Manish Gutch, Annesh Bhattacharjee, Sukriti Kumar, Durgesh Pushkar
Hashimoto's encephalitis is a rare, heterogeneous and completely treatable form of neuroendocrine disorder manifesting with seizures, stroke-like episodes, encephalopathy, dementia and variable neuropsychiatric manifestations. It is generally associated with a background of Hashimoto's Thyroiditis, and the patient has high titers of antithyroid antibodies, especially antithyroid peroxidase antibodies. This entity responds dramatically to corticosteroids, hence should be always considered and excluded while treating a patient with encephalopathy in the background of a thyroid disease...
July 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28775130/occupational-pesticide-exposure-and-subclinical-hypothyroidism-among-male-pesticide-applicators
#9
Catherine C Lerro, Laura E Beane Freeman, Curt T DellaValle, Muhammad G Kibriya, Briseis Aschebrook-Kilfoy, Farzana Jasmine, Stella Koutros, Christine G Parks, Dale P Sandler, Michael C R Alavanja, Jonathan N Hofmann, Mary H Ward
OBJECTIVES: Animal studies suggest that exposure to pesticides may alter thyroid function; however, few epidemiologic studies have examined this association. We evaluated the relationship between individual pesticides and thyroid function in 679 men enrolled in a substudy of the Agricultural Health Study, a cohort of licensed pesticide applicators. METHODS: Self-reported lifetime pesticide use was obtained at cohort enrolment (1993-1997). Intensity-weighted lifetime days were computed for 33 pesticides, which adjusts cumulative days of pesticide use for factors that modify exposure (eg, use of personal protective equipment)...
August 3, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28674524/psoriasis-psoriatic-arthritis-and-thyroid-autoimmunity
#10
REVIEW
Ilaria Ruffilli, Francesca Ragusa, Salvatore Benvenga, Roberto Vita, Alessandro Antonelli, Poupak Fallahi, Silvia Martina Ferrari
Psoriasis (PsO) is a chronic relapsing/remitting autoimmune skin disease, associated with an increased risk of other autoimmune disorders. Psoriatic arthritis (PsA) is a chronic inflammatory arthritis occurring approximately in 30% of PsO patients. Sporadic cases of association between PsO and autoimmune thyroid disorders (AITDs) have been reported. However, two different recent studies did not find any association between them. In patients with PsO and PsA, an association with AITD has been shown by most of the studies in adults, but not in the juvenile form...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28674523/systemic-lupus-erythematosus-and-thyroid-autoimmunity
#11
REVIEW
Silvia Martina Ferrari, Giusy Elia, Camilla Virili, Marco Centanni, Alessandro Antonelli, Poupak Fallahi
Most of the studies present in the literature show a high prevalence, and incidence, of new cases of hypothyroidism and autoimmune thyroiditis (AT) in systemic lupus erythematosus (SLE) patients, overall in female gender. A limited number of cases of Graves' disease have been also reported in SLE patients, in agreement with the higher prevalence of thyroid autoimmunity. It has been also demonstrated that a Th1 predominance is associated with AT in SLE patients. Furthermore, a higher prevalence of papillary thyroid cancer has been recently reported in SLE, in particular in the presence of thyroid autoimmunity...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28658146/diplopia-in-a-patient-with-hashimoto-s-thyroiditis-a-case-report-and-literature-review
#12
REVIEW
Chengqun Ju, Linna Zhang
BACKGROUND: A case report of Hashimoto's thyroiditis-associated ophthalmopathy that masqueraded as double elevator palsy in 1 eye. CASE PRESENTATION: A 54-year-old woman presented to our strabismus clinic with diplopia for 1 year. She was diagnosed with double elevator palsy in the left eye. The forced duction test yielded positive findings for the inferior rectus of the left eye; hence, computed tomography of the orbit and thyroid-associated blood tests were performed; surprisingly, the thyroid function test results were consistent with hypothyroidism and the antibody results such as antithyroglobulin and antithyroid peroxidase were markedly elevated, and the patient was diagnosed with Hashimoto's thyroiditis and treated with corticosteroids...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28653416/design-of-anti-thyroid-drugs-binding-studies-and-structure-determination-of-the-complex-of-lactoperoxidase-with-2-mercaptoimidazole-at-2-30-%C3%A3-resolution
#13
Harsh V Sirohi, Prashant K Singh, Naseer Iqbal, Pradeep Sharma, Amit K Singh, Punit Kaur, Sujata Sharma, Tej P Singh
Lactoperoxidase (LPO) belongs to mammalian heme peroxidase superfamily, which also includes myeloperoxidase (MPO), eosinophil peroxidase (EPO), and thyroid peroxidase (TPO). LPO catalyzes the oxidation of a number of substrates including thiocyanate while TPO catalyzes the biosynthesis of thyroid hormones. LPO is also been shown to catalyze the biosynthesis of thyroid hormones indicating similar functional and structural properties. The binding studies showed that 2-mercaptoimidazole (MZY) bound to LPO with a dissociation constant of 0...
October 2017: Proteins
https://www.readbyqxmd.com/read/28487744/atorvastatin-diltiazem-combination-induced-rhabdomyolysis-leading-to-diagnosis-of-hypothyroidism
#14
N D B Ehelepola, S M B Y Sathkumara, H M P A G S Bandara, K L R Kalupahana
Statins and hypothyroidism, independently, can rarely cause rhabdomyolysis. The combination of them especially with concurrent intake of drugs such as diltiazem increases the risk of rhabdomyolysis. Hashimoto's encephalopathy is a rare condition associated with Hashimoto's thyroiditis and some patients with that can present with a stroke like picture. An elderly male who has been on atorvastatin for three years and on diltiazem for a week presented with sudden onset inability to walk and confusion. On examination muscle tenderness was noticed and creatine kinase levels indicated rhabdomyolysis which we attributed to atorvastatin...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28484400/steroid-responsive-chronic-schizophreniform-syndrome-in-the-context-of-mildly-increased-antithyroid-peroxidase-antibodies
#15
Dominique Endres, Evgeniy Perlov, Anne Nicole Riering, Viktoria Maier, Oliver Stich, Rick Dersch, Nils Venhoff, Daniel Erny, Irina Mader, Ludger Tebartz van Elst
BACKGROUND: Schizophreniform syndromes can be divided into primary forms from polygenic causes or secondary forms due to immunological, epileptiform, monogenic, or degenerative causes. Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a secondary immunological form associated with increased thyroid antibodies, such as antithyroid peroxidase antibodies and shows a good response to corticosteroids. CASE PRESENTATION: We present the case of a 41-year-old woman suffering from a schizophreniform syndrome...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28479803/psychiatric-presentations-heralding-hashimoto-s-encephalopathy-a-systematic-review-and-analysis-of-cases-reported-in-literature
#16
REVIEW
Vikas Menon, Karthick Subramanian, Jaiganesh Selvapandian Thamizh
Hashimoto's encephalopathy (HE) may often present initially with psychiatric symptoms. These presentations are often variable in clinical aspects, and there has been no systematic analysis of the numerous psychiatric presentations heralding an eventual diagnosis of HE which will guide clinicians to make a correct diagnosis of HE. This systematic review was done to analyze the demographic characteristics, symptom typology, and clinical and treatment variables associated with such forerunner presentations. Electronic databases such as PubMed, ScienceDirect, and Google Scholar databases were searched to identify potential case reports that described initial psychiatric presentations of HE in English language peer-reviewed journals...
April 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28468766/regorafenib-induced-hypothyroidism-and-cancer-related-fatigue-is-there-a-potential-link
#17
Fabiana Pani, Matteo Massidda, Valeria Pusceddu, Marco Puzzoni, Elena Massa, Clelia Madeddu, Mario Scartozzi, Stefano Mariotti
OBJECTIVE: Thyroid dysfunction has been reported during Regorafenib (Reg) administration, but no detailed study is presently available. DESIGN: Prospective, observational cohort study. Patients with documented metastatic colorectal cancer and progression of disease during or within 3 months after the last standard therapy, with no evidence and history of previous thyroid disease were enrolled. METHODS: Twenty-five consecutive patients were evaluated before and 8-50 weeks after initiating Reg therapy by monthly clinical, ultrasound and laboratory (thyrotropin (TSH), free thyroxine (fT4), antithyroglobulin (TgAb) and antithyroid peroxidase (TPOAb)) evaluation...
July 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28449636/intrathecal-thyroid-autoantibody-synthesis-in-a-subgroup-of-patients-with-schizophreniform-syndromes
#18
Dominique Endres, Rick Dersch, Benedikt Hochstuhl, Bernd Fiebich, Tilman Hottenrott, Evgeniy Perlov, Simon Maier, Benjamin Berger, Annette Baumgartner, Nils Venhoff, Oliver Stich, Ludger Tebartz van Elst
Schizophreniform syndromes in combination with autoimmune thyroiditis and increased serum thyroid antibodies lead healthcare practitioners to consider a diagnosis of Hashimoto's encephalopathy. To detect specific biomarkers, the authors analyzed whether intrathecal antithyroid antibody synthesis occurred in a subgroup of schizophreniform patients. In doing so, the authors analyzed thyroid antibodies in paired cerebrospinal fluid and serum samples from 100 schizophreniform patients. Increased antibody indices (AIs) for antithyroid peroxidase or antithyroglobulin autoantibodies in 13 schizophreniform patients were found...
April 28, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28425252/allergic-and-autoimmune-disorders-in-families-with-selective-iga-deficiency
#19
Mustafa Erkoçoğlu, Ayşe Metin, Ayşenur Kaya, Celal Özcan, Ayşegül Akan, Ersoy Civelek, Murat Çapanoğlu, Tayfur Giniş, Can Naci Kocabaş
BACKGROUND/AIM: IgA deficiency is the most common human primary immunodeficiency. The prevalence of allergic disorders and autoimmunity is thought to be increased in selective IgA deficiency (sIgAD). However, it is currently unclear if these disorders coincide within these families. We aimed to evaluate the frequency of allergic and autoimmune disorders in children with sIgAD and their first-degree relatives (FDRs). MATERIALS AND METHODS: The study included 81 children diagnosed with sIgAD and 274 of their FDRs...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28356911/factors-associated-with-the-prevalence-of-thyroid-nodules-and-goiter-in-middle-aged-euthyroid-subjects
#20
Dalia Dauksiene, Janina Petkeviciene, Jurate Klumbiene, Rasa Verkauskiene, Jelena Vainikonyte-Kristapone, Audrone Seibokaite, Jonas Ceponis, Vygantas Sidlauskas, Laura Daugintyte-Petrusiene, Antanas Norkus, Birute Zilaitiene
The aim of the present study was to determine associations of thyroid hormone levels and different metabolic parameters and anthropometric measurements with volume of nodular and nonnodular thyroid as well as with prevalence of goiter and thyroid nodules in middle-aged euthyroid subjects. Methods. The study consisted of 317 euthyroid subjects aged 48-49 from the Kaunas Cardiovascular Risk Cohort study. Thyroid-stimulating hormone (TSH), free thyroxine (FT4), and antithyroid peroxidase antibody (ATPO) levels, as well as anthropometric and metabolic parameters and smoking information, were evaluated...
2017: International Journal of Endocrinology
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