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https://www.readbyqxmd.com/read/27905665/multiple-paternity-in-a-wild-population-of-armadillidium-vulgare-influence-of-infection-with-wolbachia
#1
V Valette, S Durand, N Bech, F Grandjean, S Beltran-Bech
Female multiple mating has been extensively studied to understand how nonobvious benefits, generally thought to be of genetic nature, could overcome heavy costs such as an increased risk of infection during mating. However, the impact of infection itself on multiple mating has rarely been addressed. The interaction between the bacterium Wolbachia and its terrestrial crustacean host, Armadillidium vulgare, is a relevant model to investigate this question. In this association, Wolbachia is able to turn genetic males into functional females (i...
November 4, 2016: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/27904025/early-raas-blockade-exerts-renoprotective-effects-in-autosomal-recessive-alport-syndrome
#2
Nao Uchida, Naonori Kumagai, Kandai Nozu, Xue Jun Fu, Kazumoto Iijima, Yoshiaki Kondo, Shigeo Kure
Alport syndrome is a progressive renal disease caused by mutations in COL4A3, COL4A4, and COL4A5 genes that encode collagen type IV alpha 3, alpha 4, and alpha 5 chains, respectively. Because of abnormal collagen chain, glomerular basement membrane becomes fragile and most of the patients progress to end-stage renal disease in early adulthood. COL4A5 mutation causes X-linked form of Alport syndrome, and two mutations in either COL4A3 or COL4A4 causes an autosomal recessive Alport syndrome. Recently, renin-angiotensin-aldosterone system (RAAS) blockade has been shown to attenuate effectively disease progression in Alport syndrome...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27902122/fathers-can-play-central-role-in-tackling-child-health-crisis
#3
(no author information available yet)
Fathers are being denied involvement in their children's health care, with potentially devastating consequences, the RCN International Centenary Conference heard last week.
November 30, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27901293/live-birth-sex-ratios-and-father-s-geographic-origins-in-jerusalem-1964-1976
#4
J Groeger, M Opler, K Kleinhaus, M C Perrin, R Calderon-Margalit, O Manor, O Paltiel, D Conley, S Harlap, D Malaspina
OBJECTIVE: To examine whether ancestry influenced sex ratios of offspring in a birth cohort before parental antenatal sex selection influenced offspring sex. METHODS: We measured the sex ratio as the percent of males according to countries of birth of paternal and maternal grandfathers in 91,459 live births from 1964 to 1976 in the Jerusalem Perinatal Study. Confidence limits (CI) were computed based on an expected sex ratio of 1.05, which is 51.4% male. RESULTS: Of all live births recorded, 51...
November 30, 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/27900762/multiple-levels-of-family-factors-and-oppositional-defiant-disorder-symptoms-among-chinese-children
#5
Xiuyun Lin, Longfeng Li, Melissa A Heath, Peilian Chi, Shousen Xu, Xiaoyi Fang
Family factors are closely associated with child developmental outcomes. This study examined the relationship of oppositional defiant disorder (ODD) symptoms and factors at whole family, dyadic, and individual levels in Chinese children. Participants, who were recruited from 14 primary schools in north, east, and south-west China, included 80 father-child dyads and 169 mother-child dyads. Children in the participating dyads were previously diagnosed with ODD. Results revealed that family cohesion/adaptability was indirectly associated with ODD symptoms via parent-child relationship and child emotion regulation...
November 30, 2016: Family Process
https://www.readbyqxmd.com/read/27900368/whole-exome-sequencing-reveals-an-inherited-r566x-mutation-of-the-epithelial-sodium-channel-%C3%AE-subunit-in-a-case-of-early-onset-phenotype-of-liddle-syndrome
#6
Linda M Polfus, Eric Boerwinkle, Richard A Gibbs, Ginger Metcalf, Donna Muzny, Narayanan Veeraraghavan, Megan Grove, Sanjay Shete, Stephanie Wallace, Dianna Milewicz, Neil Hanchard, James R Lupski, Syed Shahrukh Hashmi, Monesha Gupta-Malhotra
To comprehensively evaluate a European-American child with severe hypertension, whole-exome sequencing (WES) was performed on the child and parents, which identified causal variation of the proband's early-onset disease. The proband's hypertension was resistant to treatment, requiring a multiple drug regimen including amiloride, spironolactone, and hydrochlorothiazide. We suspected a monogenic form of hypertension because of the persistent hypokalemia with low plasma levels of renin and aldosterone. To address this, we focused on rare functional variants and indels, and performed gene-based tests incorporating linkage scores and allele frequency and filtered on deleterious functional mutations...
November 2016: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/27899714/parental-sleep-quality-and-behavior-problems-of-children-with-autism
#7
Iulia Mihaila, Sigan L Hartley
This study explored the impact of parental sleep quality on the experience of behavior problems by children with autism spectrum disorder. A 14-day daily diary was used in a sample of 176 mother-father couples. Dyadic multilevel models were conducted to examine the between-person and within-person effects of previous-night sleep quality on parents' rating of level of behavior problems by the child with autism spectrum disorder and level of positive and negative affect. Results indicated that persistently poor sleep quality was associated with between-person differences in initial rating of level of behavior problems by the child with autism spectrum disorder for mothers...
November 29, 2016: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/27899712/disparity-in-report-of-autism-related-behaviors-by-social-demographic-characteristics-findings-from-a-community-based-study-in-taiwan
#8
Peng-Chou Tsai, Rebecca A Harrington, For-Wey Lung, Li-Ching Lee
The Social Communication Questionnaire is one of the most commonly used screening tools for autism spectrum disorder. The Social Communication Questionnaire is a caregiver-reported questionnaire with 40 items based on questions from the Autism Diagnostic Interview-Revised. This study collected Social Communication Questionnaire data from a community-based, multi-stage case identification design epidemiologic study in one socioeconomically disadvantaged county in Taiwan. The Social Communication Questionnaire was distributed to 3034 school children, aged 6-8 years...
November 29, 2016: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/27899382/a-metastatic-mouse-model-identifies-genes-that-regulate-neuroblastoma-metastasis
#9
Bo Kyung Alex Seong, Kelly E Fathers, Robin M Hallett, Christina K Yung, Lincoln D Stein, Samar Mouaaz, Lynn Kee, Cynthia Hawkins, Meredith S Irwin, David R Kaplan
Metastatic relapse is the major cause of death in pediatric neuroblastoma (NB), where there remains a lack of therapies to target this stage of disease. To understand the molecular mechanisms mediating NB metastasis, we developed a mouse model using intracardiac injection and in vivo selection to isolate malignant cell subpopulations with a higher propensity for metastasis to bone and the central nervous system. Gene expression profiling revealed primary and metastatic cells as two distinct cell populations defined by differential expression 412 genes and multiple pathways, including CADM1, SPHK1 and YAP/TAZ whose expression independently predicted survival...
November 29, 2016: Cancer Research
https://www.readbyqxmd.com/read/27899188/familial-prostate-cancer
#10
Veda N Giri, Jennifer L Beebe-Dimmer
Prostate cancer is the most commonly diagnosed cancer among men in the United States as well as most Western countries. A significant proportion of men report having a positive family history of prostate cancer in a first-degree relative (father, brother, son), which is important in that family history is one of the only established risk factors for the disease and plays a role in decision-making for prostate cancer screening. Familial aggregation of prostate cancer is considered a surrogate marker of genetic susceptibility to developing the disease, but shared environment cannot be excluded as an explanation for clustering of cases among family members...
October 2016: Seminars in Oncology
https://www.readbyqxmd.com/read/27899058/correlates-of-child-father-and-child-mother-attachment-in-the-preschool-years
#11
Jean-François Bureau, Jodi Martin, Kim Yurkowski, Sabrina Schmiedel, Jeffry Quan, Ellen Moss, Audrey-Ann Deneault, Dominique Pallanca
The increase in fathers' involvement in childrearing, particularly beyond infancy, warrants research exploring factors influencing the quality of child-father attachment relationships, and the impact of these relationships on children's social development. The current investigation explored various correlates of preschoolers' child-father attachment security to both parents, including contextual factors (i.e., socioeconomic status, child temperament, parenting stress), parental play sensitivity, and child social adaptation...
November 30, 2016: Attachment & Human Development
https://www.readbyqxmd.com/read/27898704/genetic-structure-and-potential-environmental-determinants-of-local-genetic-diversity-in-japanese-honeybees-apis-cerana-japonica
#12
Teruyoshi Nagamitsu, Mika Yasuda, Fuki Saito-Morooka, Maki N Inoue, Mio Nishiyama, Koichi Goka, Shinji Sugiura, Kaoru Maeto, Kimiko Okabe, Hisatomo Taki
Declines in honeybee populations have been a recent concern. Although causes of the declines remain unclear, environmental factors may be responsible. We focused on the potential environmental determinants of local populations of wild honeybees, Apis cerana japonica, in Japan. This subspecies has little genetic variation in terms of its mitochondrial DNA sequences, and genetic variations at nuclear loci are as yet unknown. We estimated the genetic structure and environmental determinants of local genetic diversity in nuclear microsatellite genotypes of fathers and mothers, inferred from workers collected at 139 sites...
2016: PloS One
https://www.readbyqxmd.com/read/27897316/internalizing-symptoms-and-personality-traits-color-parental-reports-of-child-temperament
#13
D Angus Clark, C Emily Durbin, M Brent Donnellan, Tricia K Neppl
OBJECTIVE: Depressed parents have negatively distorted views of the personalities and behaviors of their children. Our goal was to evaluate how other internalizing symptoms and personality traits relate to perceptions of child temperament using data from mothers and fathers as well as novel statistical method for modeling multi-informant data. METHOD: We applied the trifactor model (Bauer et al., 2013) to data collected from the parents of 273 children (ages 3-5 years)...
November 29, 2016: Journal of Personality
https://www.readbyqxmd.com/read/27896502/supporting-of-the-fathers-to-visit-their-infants-in-neonatal-intensive-care-unit-decreases-their-stress-level-a-pretest-posttest-quasi-experimental-study
#14
Funda Kardaş Özdemir, Dilek Küçük Alemdar
It is known that fathers whose infants are hospitalized in NICUs (Neonatal Intensive Care Units) are severely stressed. This study was conducted for the purpose of determining the effect of supporting and visiting infants in NICUs on stress levels of Turkish fathers. This was a pretest-posttest quasi-experimental study. The population of the study consisted of 47 fathers who had their infants receiving treatment in NICU at a state hospital in the eastern Turkey and agreed to participate in the study. The data were collected by using "Father-Infant Introductory Information Form" and "Parental Stressor Scale: Neonatal Intensive Care Unit, PSS:NICU"...
November 28, 2016: Community Mental Health Journal
https://www.readbyqxmd.com/read/27896313/effects-of-paternal-predation-risk-and-rearing-environment-on-maternal-investment-and-development-of-defensive-responses-in-the-offspring
#15
Austin C Korgan, Elizabeth O'Leary, Jessica Bauer, Aidan Fortier, Ian C G Weaver, Tara S Perrot
Detecting past experiences with predators of a potential mate informs a female about prevailing ecological threats, in addition to stress-induced phenotypes that may be disseminated to offspring. We examined whether prior exposure of a male rat to a predator (cat) odor influences the attraction of a female toward a male, subsequent mother-infant interactions and the development of defensive (emotional) responses in the offspring. Females displayed less interest in males that had experienced predator odor. Mothers that reared young in larger, seminaturalistic housing provided more licking and grooming and active arched back-nursing behavior toward their offspring compared with dams housed in standard housing, although some effects interacted with paternal experience...
November 2016: ENeuro
https://www.readbyqxmd.com/read/27895808/mendelian-inheritance-of-trimodal-cpg-methylation-sites-suggests-distal-cis-acting-genetic-effects
#16
Shaza B Zaghlool, Mashael Al-Shafai, Wadha A Al Muftah, Pankaj Kumar, Christian Gieger, Melanie Waldenberger, Mario Falchi, Karsten Suhre
BACKGROUND: Environmentally influenced phenotypes, such as obesity and insulin resistance, can be transmitted over multiple generations. Epigenetic modifications, such as methylation of DNA cytosine-guanine (CpG) pairs, may be carriers of inherited information. At the population level, the methylation state of such "heritable" CpG sites is expected to follow a trimodal distribution, and their mode of inheritance should be Mendelian. METHODS: Using the Illumina Infinium 450 K DNA methylation array, we determined DNA CpG-methylation in blood cells from a family cohort 123 individuals of Arab ethnicity, including 18 elementary father-mother-child trios, we asked whether Mendelian inheritance of CpG methylation is observed, and most importantly, whether it is independent of any genetic signals...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27895453/a-case-of-a-living-related-kidney-transplantation-after-ex-vivo-repair-of-the-donor-renal-artery-aneurysm
#17
P Christopoulos, A Faryal, M Dosani, D Rix, D Talbot
BACKGROUND: Kidney transplantation is the definite surgical treatment for end-stage renal disease. Shortage of organs and the increasing number of patients with end-stage renal disease has led to an expansion of the selection criteria promoting the use of organs from marginal donors. Use of kidneys with renal artery aneurysm (RAA) is one such example. Description of the case: We report a case of living-related kidney transplantation from a 46-year-old female donor with unilateral RAA to her 68-year-old father...
January 2016: Hippokratia
https://www.readbyqxmd.com/read/27895188/antisocial-alcoholism-in-parents-of-adolescents-and-young-adults-with-childhood-adhd
#18
Brooke S G Molina, Elizabeth M Gnagy, Heather M Joseph, William E Pelham
OBJECTIVE: Test the hypothesis that alcoholism, including antisocial alcoholism, is more prevalent among mothers and fathers of children with versus without ADHD. METHOD: Mothers (312 ADHD group, 235 non-ADHD group) and fathers (291 ADHD group, 227 non-ADHD group) in the Pittsburgh ADHD Longitudinal Study were interviewed along with their adolescent and young adult offspring. RESULTS: Maternal and paternal alcoholism, with and without comorbid antisociality, was more prevalent in the ADHD group...
November 27, 2016: Journal of Attention Disorders
https://www.readbyqxmd.com/read/27894371/pervasive-influence-of-maternal-and-paternal-criminal-offending-on-early-childhood-development-a-population-data-linkage-study
#19
K R Laurens, S Tzoumakis, M Kariuki, M J Green, M Hamde, F Harris, V J Carr, K Dean
BACKGROUND: Parental criminal offending is an established risk factor for offending among offspring, but little evidence is available indicating the impact of offending on early childhood functioning. We used data from a large Australian population cohort to determine associations between exposure to parental offending and a range of developmental outcomes at age 5 years. METHOD: Multi-generation data in 66 477 children and their parents from the New South Wales Child Development Study were combined using data linkage...
November 29, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27893823/shared-decision-making-at-the-limit-of-viability-a-blueprint-for-physician-action
#20
Thierry Daboval, Sarah Shidler, Daniel Thomas
OBJECTIVE: To document interactions during the antenatal consultation between parents and neonatologist that parents linked to their satisfaction with their participation in shared decision making for their infant at risk of being born at the limit of viability. METHODS: This multiple-case ethnomethodological qualitative research study, included mothers admitted for a threatened premature delivery between 200/7 and 266/7 weeks gestation, the father, and the staff neonatologist conducting the clinical antenatal consultation...
2016: PloS One
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