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https://www.readbyqxmd.com/read/28535175/parental-age-and-risk-of-pediatric-cancer-in-the-offspring-a-population-based-record-linkage-study-in-california
#1
Rong Wang, Catherine Metayer, Libby Morimoto, Joseph L Wiemels, Andrew T DeWan, Alice Kang, Xiaomei Ma
By linking birth records and cancer registry data from California, we conducted a population-based study with 23,419 cases and 87,593 matched controls born in 1978-2009 to investigate the relation of parental age to risk of pediatric cancer. Compared to children born to mothers aged 20-24 years, those born to mothers in older age groups had a 13% to 36% increased risk of pediatric cancer, the odds ratio (OR) for each 5-year maternal age increase was 1.06 (95% confidence interval[CI]: 1.04,1.09). For cancer diagnosed at 0-14 and 15-19 years, the OR for each 5-year increase in maternal age was1...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28534276/disentangling-child-specific-and-family-wide-processes-underlying-negative-mother-child-transactions
#2
André Plamondon, Dillon T Browne, Sheri Madigan, Jennifer M Jenkins
The current study examines the transactional processes between maternal negativity and child disruptive behavior during early childhood, using a sibling comparison design. This design allows for a more sophisticated test of the behavioral training hypothesis than is possible when only one child per family is included in the analysis as it excludes two confounders (passive gene-environment correlation and family-wide environmental influence). Three hundred and ninety-seven families were visited on three occasions when the target child was 1...
May 23, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28534223/immunoglobulin-m-gene-association-with-autoantibody-reactivity-and-type-1-diabetes
#3
Inês Rolim, Nádia Duarte, Gabriela Barata, João Costa, Luís Gardete-Correia, José Boavida, Rui Duarte, João Raposo, Zulmira Peerally, Manuela Catarino, Carlos Penha-Gonçalves
Several lines of evidence show that autoimmune responses evolving in type 1 diabetes (T1D) patients include the generation of multi-reactive autoantibody (AutoAb) repertoires, but their role in T1D pathogenesis remains elusive. We tested the hypothesis that variants at the immunoglobulin heavy chain (IGH) locus are genetic determinants of AutoAbs against pancreatic antigens and contribute to T1D susceptibility. With this aim, two independent study designs were used: a case-control study and a family-based cohort comprising a total of 240 T1D patients, 172 first-degree relatives (mother and/or father), and 130 unrelated healthy controls living in Portugal...
May 22, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28534168/father-s-obesity-programs-the-adipose-tissue-in-the-offspring-via-the-local-renin-angiotensin-system-and-mapks-pathways-especially-in-adult-male-mice
#4
Fernanda Ornellas, Isabele Bringhenti, Brenda Akemi N F Mattos, Carlos Alberto Mandarim-de-Lacerda, Marcia Barbosa Aguila
PURPOSE: Studies demonstrated the influence of mother's obesity on offspring. However, the father is also related to programming the future generation. The study aimed to evaluate the effects of father's obesity upon white adipose tissue (WAT) remodeling, resulting in activation of signaling pathways and inflammation in male and female offspring. METHODS: Male C57BL/6 mice received control diet (lean father group; 17% energy from lipids) or high-fat diet (obese father group; 49% energy from lipids) for 8 weeks before mating...
May 22, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28534044/hsp-and-deafness-neurocristopathy-caused-by-a-novel-mosaic-sox10-mutation
#5
Sandra Donkervoort, Diana Bharucha-Goebel, Pomi Yun, Ying Hu, Payam Mohassel, Ahmet Hoke, Wadih M Zein, Daniel Ezzo, Andrea M Atherton, Ann C Modrcin, Majed Dasouki, A Reghan Foley, Carsten G Bönnemann
OBJECTIVE: To identify the underlying genetic cause in 2 sisters affected with progressive lower extremity spasticity, neuropathy, and early-onset deafness. METHODS: Whole-exome sequencing was performed, and segregation testing of variants was investigated using targeted Sanger sequencing. An inherited paternal mosaic mutation was further evaluated through quantitative analysis of the ratio of mutant vs wild-type allele in genomic DNA from various tissues, including blood, dermal fibroblasts, and saliva...
June 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28533422/paternal-hyperglycemia-in-rats-exacerbates-the-development-of-obesity-in-offspring
#6
Xiaoqin Shi, Xinyu Li, Yi Hou, Xuemei Cao, Yuyao Zhang, Heng Wang, Hongying Wang, Chuan Peng, Jibin Li, Qifu Li, Chaodong Wu, Xiaoqiu Xiao
Parental history with obesity or diabetes will increase the risk for developing metabolic diseases in offspring. However, literatures as to transgenerational inheritance of metabolic dysfunctions through male lineage are relatively scarce. In current study, we aimed to evaluate influences of paternal hyperglycemia on metabolic phenotypes in offspring. Male SD rats were ip injected with streptozotocin (STZ) or citrate buffer (CB, as control). STZ-injected rats with glucose levels higher than 16 mM were selected to breed with normal female rats...
May 22, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28533070/maternal-and-paternal-periconceptional-nutrition-as-an-indicator-of-offspring-metabolic-syndrome-risk-in-later-life-through-epigenetic-imprinting-a-systematic-review
#7
REVIEW
Ashley R Dunford, Janice M Sangster
AIMS: This review examined whether maternal and paternal periconceptional nutrition effects an offspring's likelihood of developing chronic metabolic related conditions due to epigenetic imprinting. METHODS: A literature search was conducted in multiple science databases and limited to studies published after 2012, in English language and peer reviewed. The data from selected articles were extracted and a qualitative approach was employed due to heterogeneity of results...
May 10, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28532982/maternal-and-paternal-physical-abuse-unique-and-joint-associations-with-child-behavioral-problems
#8
Naixue Cui, Janet A Deatrick, Jianghong Liu
Although there is a substantial amount of literature documenting the relationship between child abuse and behavioral problems in China, there is, on the other hand, a limited number of studies on the joint and unique associations of maternal and paternal physical abuse with child behaviors within the Chinese context. The present study, using the family systems theory as the theoretical framework, aims to examine these joint and the unique associations of maternal and paternal physical abuse with externalizing and internalizing behaviors among a community sample of Chinese children...
May 19, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28532490/prevalence-and-determinants-of-childhood-mortality-in-nigeria
#9
Sanni Yaya, Michael Ekholuenetale, Godson Tudeme, Shah Vaibhav, Ghose Bishwajit, Bernard Kadio
BACKGROUND: Childhood mortality has remained a major challenge to public health amongst families in Nigeria and other developing countries. The menace of incessant childhood mortality has been a major concern and this calls for studies to generate new scientific evidence to determine its prevalence and explore predisposing factors associated with it in Nigeria. METHOD: Data was obtained from Nigeria DHS, 2013. The study outcome variable was the total number of children lost by male partners and female partners respectively who were married...
May 22, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28531821/examining-the-physical-health-and-lifestyle-of-young-people-at-ultra-high-risk-for-psychosis-a-qualitative-study-involving-service-users-parents-and-clinicians
#10
Rebekah Carney, Jack Cotter, Tim Bradshaw, Alison R Yung
Emerging evidence suggests young people at ultra-high risk for psychosis (UHR) are also at-risk for poor physical health, and display high rates of modifiable cardiometabolic risk factors. However, before we can develop effective interventions there is a need to understand factors affecting lifestyle choices in the UHR group. We conducted semi-structured qualitative interviews with 20 UHR individuals (50% male; mean age 21.7), 5 parents (4 mothers, 1 father), and 6 clinicians from early intervention services in the Northwest of England to identify barriers and facilitators to living a healthy lifestyle, including achieving regular exercise, eating well and refraining from excessive substance use...
May 16, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28531781/body-mass-index-kinetics-around-adiposity-rebound-in-anorexia-nervosa-a-case-control-study
#11
Rémi Neveu, Dorine Neveu, Edouard Carrier, Nadia Ourrad, Alain Perroud, Alain Nicolas
BACKGROUND AND OBJECTIVE: Anorexia nervosa (AN) is associated with parameters involved in body mass index (BMI) regulation. Contrary to obesity, BMI kinetics around the adiposity rebound is not documented in AN. This study aimed at investigating which characteristics of BMI kinetics around the adiposity rebound are associated with AN. METHODS: Multicentre case-control study with 101 inpatient women with AN onset after 10 years of age, and 101 healthy women, all free of overweight history and matched for age, level of education and fathers' socio-professional status...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28530410/correction-to-kujawa-proudfit-and-klein-2014
#12
(no author information available yet)
Reports an error in "Neural reactivity to rewards and losses in offspring of mothers and fathers with histories of depressive and anxiety disorders" by Autumn Kujawa, Greg Hajcak Proudfit and Daniel N. Klein (Journal of Abnormal Psychology, 2014[May], Vol 123[2], 287-297). In the original article, there was an error in the Measures section. The article stated that the EEG data were band-pass filtered with cutoffs of 0.1 and 30 Hz and baseline corrected using the 200 ms interval prior to feedback. Instead, the data were actually filtered with cutoffs of 0...
May 22, 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28530043/the-happy-teen-programme-a-holistic-outpatient-clinic-based-approach-to-prepare-hiv-infected-youth-for-the-transition-from-paediatric-to-adult-medical-care-services-in-thailand
#13
Rangsima Lolekha, Vitharon Boon-Yasidhi, Yossawadee Na-Nakorn, Boonying Manaboriboon, Warunee Punpanich Vandepitte, Michael Martin, Jariya Tarugsa, Wipada Nuchanard, Pimsiri Leowsrisook, Ketwadee Lapphra, Piyarat Suntarattiwong, Vorapathu Thaineua, Kulkanya Chokephaibulkit
INTRODUCTION: We developed an 18-month Happy Teen 2 (HT2) programme comprised of a one-day workshop, two half-day sessions, and three individual sessions to prepare HIV-infected youth for the transition from paediatric to adult HIV care services. We describe the programme and evaluate the change in youth's knowledge scores. METHODS: We implemented the HT2 programme among HIV-infected Thai youth aged 14-22 years who were aware of their HIV status and receiving care at two hospitals in Bangkok (Siriraj Hospital, Queen Sirikit National Institute of Child Health [QSNICH])...
May 16, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28529398/are-mothers-and-fathers-parenting-characteristics-associated-with-emerging-adults-academic-engagement
#14
Emily A Waterman, Eva S Lefkowitz
Although parenting is clearly linked to academic engagement in adolescence, less is known about links between parenting and academic engagement in emerging adulthood. A diverse sample of college students (N = 633; 53.1% female, 45.7% White/European American, 28.3% Asian American/Hawaiian/Pacific Islander, 26.4% Hispanic/Latino American, 21.6% Black/African American, and 2.8% Native American/American Indian) answered surveys about mothers' and fathers' parenting style, parent-offspring relationship quality, academic attitudes, academic behaviors, and academic performance...
June 2017: Journal of Family Issues
https://www.readbyqxmd.com/read/28529304/sebastian-kneipp-and-the-natural-cure-movement-of-germany-between-naturalism-and-modern-medicine
#15
Youkyung Ko
This study discusses the historical significance of the Natural Cure Movement of Germany, centering on the Kneipp Cure, a form of hydrotherapy practiced by Father Sebastian Kneipp (1821-1897). The Kneipp Cure rested on five main tenets: hydrotherapy, exercise, nutrition, herbalism, and the balance of mind and body. This study illuminates the reception of the Kneipp Cure in the context of the trilateral relationship among the Kneipp Cure, the Natural Cure Movement in general, and modern medicine. The Natural Cure Movement was ideologically based on naturalism, criticizing industrialization and urbanization...
December 2016: Ŭi Sahak
https://www.readbyqxmd.com/read/28529017/proatherogenic-lipid-profile-in-early-childhood-association-with-weight-status-at-4-years-and-parental-obesity
#16
Isolina Riaño-Galán, Ana Fernández-Somoano, Cristina Rodríguez-Dehli, Damaskini Valvi, Martine Vrijheid, Adonina Tardón
OBJECTIVES: To determine lipid profiles in early childhood and evaluate their association with weight status at 4 years of age. Additionally, we evaluated whether the risk of overweight or having an altered lipid profile was associated with parental weight status. STUDY DESIGN: Five hundred eighty two mothers and their 4-year-old children from 2 Spanish population-based cohorts were studied. Weight status in children at 4 years of age was classified as overweight or obese using the International Obesity Task Force criteria...
May 18, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28528809/efficacy-of-sibling-preparation-classes
#17
Emma E A Beyers-Carlson, Brenda L Volling
OBJECTIVE: To examine the effectiveness of sibling preparation classes to facilitate the adjustment of a firstborn child to the birth of a sibling. DESIGN: Longitudinal study with five measurement occasions: third trimester of the mother's pregnancy and 1, 4, 8, and 12 months after the sibling's birth. SETTING: Communities in southeastern Michigan. PARTICIPANTS: A total of 241 families, including mothers, fathers, and firstborn children...
May 18, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28528464/evidence-based-identification-of-key-beliefs-explaining-infant-male-circumcision-motivation-among-expectant-parents-in-zimbabwe-targets-for-behavior-change-messaging
#18
Daniel E Montaño, Mufuta Tshimanga, Deven T Hamilton, Gerald Gorn, Danuta Kasprzyk
Slow adult male circumcision uptake is one factor leading some to recommend increased priority for infant male circumcision (IMC) in sub-Saharan African countries. This research, guided by the integrated behavioral model (IBM), was carried out to identify key beliefs that best explain Zimbabwean parents' motivation to have their infant sons circumcised. A quantitative survey, designed from qualitative elicitation study results, was administered to independent representative samples of 800 expectant mothers and 795 expectant fathers in two urban and two rural areas in Zimbabwe...
May 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28527290/association-of-polymorphic-variants-of-ptpn22-tnf-and-vdr-genes-in-children-with-lupus-nephritis-a-study-in-colombian-family-triads
#19
Gloria Garavito, Eduardo Egea, Luis Fang, Clara Malagón, Carlos Olmos, Luz González, Pilar Guarnizo, Gustavo Aroca, Guillermo López, Antonio Iglesias
INTRODUCTION: Systemic lupus erythematosus is an autoimmune disease in which the severity varies according to race, sex and age of onset. This variation is also observed in the genetic markers associated with the disease, including PTPN22, VDR and TNF genes. The genetic stratification in different populations worldwide can influence the variability. OBJECTIVE: To analyze the heritability of PTPN22, VDR and TNF genetic variants and their association with pediatric lupus nephritis in Colombian families...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527042/parenting-stress-among-parents-of-children-with-congenital-diaphragmatic-hernia
#20
Elin Öst, Margret Nisell, Björn Frenckner, Carmen Mesas Burgos, Maria Öjmyr-Joelsson
PURPOSE: The aim of this study was to examine parental stress among parents of children with congenital diaphragmatic hernia (CDH). METHODS: Between 2005 and 2009, a total of 51 children with CDH were treated at Astrid Lindgren Children's Hospital. The survival rate at discharge was 86% and long-term survival rate 80%. One parent each of the long-term survivors (41 children) was included in the present study, and 34 parents (83%) agreed to participate. Participants received the Swedish Parenthood Stress Questionnaire (SPSQ)...
May 19, 2017: Pediatric Surgery International
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