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https://www.readbyqxmd.com/read/29145655/paternal-exposure-to-environmental-chemical-stress-affectsmale-offspring-s-hepatic-mitochondria
#1
Roger Godschalk, Alex Remels, Camiel Hoogendoorn, Jan van Benthem, Mirjam Luijten, Nur Duale, Gunnar Brunborg, Ann-Karin Olsen, Freek G Bouwman, Armelle Munnia, Marco Peluso, Edwin Mariman, Frederik Jan van Schooten
Pre-conceptional paternal exposures may affect offspring's health, which cannot be explained by mutations in germ cells, but by persistent changes in the regulation of gene expression. Therefore, we investigated whether pre-conceptional paternal exposure to benzo[a]pyrene (B[a]P) could alter the offspring's phenotype. Male C57BL/6 mice were exposed to B[a]P by gavage for 6 weeks, 3x per week, and were crossed with unexposed BALB-c females 6 weeks after the final exposure. The offspring was kept under normal feeding conditions and was sacrificed at 3 weeks of age...
November 14, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29145594/wellbeing-of-gay-fathers-with-children-born-through-surrogacy-a-comparison-with-lesbian-mother-families-and-heterosexual-ivf-parent-families
#2
L Van Rijn-van Gelderen, H W M Bos, T D Jorgensen, K Ellis-Davies, A Winstanley, S Golombok, B Rubio, M Gross, O Vecho, M E Lamb
STUDY QUESTION: Are there differences in levels of parental wellbeing (parental stress, psychological adjustment and partner relationship satisfaction) between gay-father families with infants born through surrogacy, lesbian-mother families with infants born through donor insemination, and heterosexual-parent families with infants born through IVF? SUMMARY ANSWER: There were no differences in parental wellbeing. WHAT IS KNOWN ALREADY: The only other study of parental wellbeing in gay-father families formed through surrogacy (mean age children: 4 years old) found no difference in couple relationship satisfaction between these families and lesbian-mother families formed through donor insemination and heterosexual-parent families formed without assisted reproductive technologies...
November 14, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29144882/adult-children-of-gay-fathers-parent-child-relationship-quality-and-mental-health
#3
Samantha L Tornello, Charlotte J Patterson
According to family systems theory, parent-child relationships are an important aspect of individual well-being. This study explored associations among parental disclosure, parent-child relationships, and well-being among 84 adult children with gay fathers. We explored associations between the adult children's well-being and the children's ages at sexual orientation disclosure, geographic distance, relationship quality and closeness with their fathers. We found that when parental disclosure had occurred earlier in the adult child's life, participants reported feeling closer to fathers in adulthood...
November 16, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/29144546/presence-of-infection-and-analysis-of-hpv-subtypes-in-girls-younger-than-9-years-old-attended-at-a-referral-service-in-esp%C3%A3-rito-santo-brazil
#4
Mariana Penha De Nadai Sartori, Lidiane Pignaton Agostini, Thaís Tristão Tovar, Raquel Silva Dos Reis, Raquel Spinassé Dettogni, Eldamária de Vargas Wolfgramm Dos Santos, Antônio Chambô Filho, Iúri Drumond Louro
PURPOSE: Human papillomavirus is found in adults and adolescents and is associated with genital warts and cervical cancer. However, it has been detected in girls younger than 10 years old. Currently, there are no prevention methods for this age group, since it is not considered a risk group. The aim of this study was to evaluate the presence of infection and HPV subtype in girls under 9 years old attended at a referral service in the State of Espírito Santo, Brazil. METHODS: Forty-three girls younger than 9 years old had gynecological brush samples collected from vulval and perineal/anal regions...
November 16, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29144419/air-pollution-and-dispensed-medications-for-asthma-and-possible-effect-modifiers-related-to-mental-health-and-socio-economy-a-longitudinal-cohort-study-of-swedish-children-and-adolescents
#5
Anna Oudin, Lennart Bråbäck, Daniel Oudin Åström, Bertil Forsberg
It has been suggested that children that are exposed to a stressful environment at home have an increased susceptibility for air pollution-related asthma. The aim here was to investigate the association between air pollution exposure and asthma, and effect modification by mental health and by socio-economic status (as markers of a stressful environment). All individuals under 18 years of age in four Swedish counties during 2007 to 2010 (1.2 million people) were included. The outcome was defined as dispensing at least two asthma medications during follow up...
November 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29144249/effect-of-antiandrogen-aromatase-inhibitor-and-gonadotropin-releasing-hormone-analog-on-adult-height-in-familial-male-precocious-puberty
#6
Ellen Werber Leschek, Armando C Flor, Joy C Bryant, Janet V Jones, Kevin M Barnes, Gordon B Cutler
OBJECTIVE: Antiandrogen, aromatase inhibitor, and gonadotropin-releasing hormone analog (GnRHa) treatment normalizes growth rate and bone maturation and increases predicted adult height (AH) in boys with familial male-limited precocious puberty (FMPP). To evaluate the effect of long-term antiandrogen, aromatase inhibitor, and GnRHa on AH, boys with FMPP who were treated were followed to AH. STUDY DESIGN: Twenty-eight boys with FMPP, referred to the National Institutes of Health, were started on antiandrogen and aromatase inhibitor at 4...
November 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29144191/paternal-involvement-and-support-and-risk-of-preterm-birth-findings-from-the-boston-birth-cohort
#7
Pamela J Surkan, Liming Dong, Yuelong Ji, Xiumei Hong, Hongkai Ji, Mary Kimmel, Wan-Yee Tang, Xiaobin Wang
OBJECTIVE: To investigate to what extent paternal involvement and support during pregnancy were associated with preterm (PTB) and small-for-gestational age (SGA) births. METHODS: Using data from the Boston Birth Cohort (n = 7047), multiple logistic regression models were performed to estimate the log odds of either PTB or SGA birth, with paternal involvement, paternal social support, and family and friend social support variables as the primary independent variables...
November 16, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29144190/factors-associated-with-paternal-perinatal-depression-in-fathers-of-newborns-in-nigeria
#8
Olatunde Ayinde, Victor O Lasebikan
INTRODUCTION: There is a lack of information on paternal postnatal depression in developing countries such as Nigeria. METHODS: This study aims to assess the prevalence of depression in fathers at the birth of their infants and the incidence of paternal postnatal depression at 6 weeks postpartum. We also examined the correlation between paternal postpartum depression (PPD) at 6 weeks and maternal PPD as well as the sociodemographic and other correlates of paternal PPD at 6 weeks...
November 16, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29143890/paternal-anxiety-in-relation-to-toddler-anxiety-the-mediating-role-of-maternal-behavior
#9
Robert C Gibler, Anne E Kalomiris, Elizabeth J Kiel
Despite robust investigations examining the impact of maternal anxiety and parenting behaviors and child anxiety risk, less is understood about the impact of paternal anxiety and parenting behaviors on child anxiety risk, particularly within the broader family context. An Actor Partner Interdependence Model (APIM) was used to examine whether paternal anxiety longitudinally predicted child anxiety risk indirectly through maternal and paternal parenting behaviors, while controlling for maternal anxiety. Both fathers and mothers of 12- to 30-month-olds (n = 94) provided self-report of their anxiety and parenting behaviors...
November 16, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/29143335/self-perceived-coparenting-of-nonresident-fathers-scale-development-and-validation
#10
W Justin Dyer, Jay Fagan, Rebecca Kaufman, Jessica Pearson, Natasha Cabrera
This study reports on the development and validation of the Fatherhood Research and Practice Network coparenting perceptions scale for nonresident fathers. Although other measures of coparenting have been developed, this is the first measure developed specifically for low-income, nonresident fathers. Focus groups were conducted to determine various aspects of coparenting. Based on this, a scale was created and administered to 542 nonresident fathers. Participants also responded to items used to examine convergent and predictive validity (i...
November 16, 2017: Family Process
https://www.readbyqxmd.com/read/29142202/genomic-mosaicism-in-paternal-sperm-and-multiple-parental-tissues-in-a-dravet-syndrome-cohort
#11
Xiaoxu Yang, Aijie Liu, Xiaojing Xu, Xiaoling Yang, Qi Zeng, Adam Yongxin Ye, Zhe Yu, Sheng Wang, August Yue Huang, Xiru Wu, Qixi Wu, Liping Wei, Yuehua Zhang
Genomic mosaicism in parental gametes and peripheral tissues is an important consideration for genetic counseling. We studied a Chinese cohort affected by a severe epileptic disorder, Dravet syndrome (DS). There were 56 fathers who donated semen and 15 parents who donated multiple peripheral tissue samples. We used an ultra-sensitive quantification method, micro-droplet digital PCR (mDDPCR), to detect parental mosaicism of the proband's pathogenic mutation in SCN1A, the causal gene of DS in 112 families. Ten of the 56 paternal sperm samples were found to exhibit mosaicism of the proband's mutations, with mutant allelic fractions (MAFs) ranging from 0...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141661/preventing-enduring-behavioural-problems-in-young-children-through-early-psychological-intervention-healthy-start-happy-start-study-protocol-for-a-randomized-controlled-trial
#12
Paul G Ramchandani, Christine O'Farrelly, Daphne Babalis, Marian J Bakermans-Kranenburg, Sarah Byford, Ellen S R Grimas, Jane E Iles, Marinus H van IJzendoorn, Julia McGinley, Charlotte M Phillips, Alan Stein, Jane Warwick, Hillary C Watt, Stephen Scott
BACKGROUND: Behavioural problems are common in early childhood, and can result in enduring costs to the individual and society, including an increased risk of mental and physical illness, criminality, educational failure and drug and alcohol misuse. Most previous research has examined the impact of interventions targeting older children when difficulties are more established and harder to change, and have rarely included fathers. We are conducting a trial of a psychological intervention delivered to families with very young children, engaging both parents where possible...
November 15, 2017: Trials
https://www.readbyqxmd.com/read/29141311/-study-on-mosaicism-of-scn1a-gene-mutation-in-parents-of-children-with-dravet-syndrome
#13
A J Liu, X X Yang, X J Xu, Q X Wu, X J Tian, X L Yang, X R Wu, L P Wei, Y H Zhang
Objective: To investigate the clinical phenotypes and the mutant allele proportion of parents with SCN1A gene mutation mosaicism of Dravet syndrome (DS) children, thus to provide guidance for family reproduction and prenatal diagnosis. Method: The clinical data and peripheral blood DNA samples of DS patients with a SCN1A gene mutation proved by Sanger sequencing were collected prospectively from February 2005 to November 2016 in Department of Pediatrics, Peking University First Hospital. The same mutation was searched in parents and other available relatives...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29141268/gastric-adenocarcinoma-and-proximal-polyposis-of-the-stomach-gapps-a-rare-recently-described-gastric-polyposis-syndrome-report-of-a-case
#14
Andrea Beer, Berthold Streubel, Reza Asari, Clemens Dejaco, Georg Oberhuber
In rare cases with multiple gastric polyps in the corpus and fundus, a recently described gastric polyposis syndrome called gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) has to be considered. We report on the findings in a patient fulfilling the criteria of this disease.A female patient born in 1977 underwent gastroscopy in 2005 due to recurrent abdominal pain. Endoscopy revealed more than 100 fundic gland polyps in the corpus and fundus. An ileocolonoscopy was inconspicuous. The patient did not take proton pump inhibitors...
November 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29140751/further-delineation-of-the-oculoauricular-syndrome-phenotype-a-new-family-with-a-novel-truncating-hmx1-mutation
#15
Ghada M H Abdel-Salam, Mohamed S Abdel-Hamid, Mennat I Mehrez, Ahmad M Kamal, Mohamed B Taher, Hanan H Afifi
Biallelic HMX1 mutations cause a very rare autosomal recessive genetic disorder termed as oculoauricular syndrome (OAS) because it is characterized only by the combination of eye and ear anomalies. We identified a new family bringing to three the total families reported with this disorder. Our proband presented with anteriorly protruded ears and malformed ear pinnae in association with microphthalmia, congenital cataract, microcornea, and iris and optic disc colobomata. Additionally, he had high and broad forehead with asymmetry giving a recognizable facial gestalt...
November 15, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29140526/risk-and-protective-factors-for-family-violence-among-low-income-fathers-implications-for-violence-prevention-and-fatherhood-programs
#16
R Anna Hayward, Laura Honegger, Amy Cristina Hammock
Over the last decade there has been an increased focus on improving father engagement to improve child and family outcomes. Recent research suggests that child and family outcomes improve with increased fatherhood engagement. This exploratory study examined risk and protective factors associated with approval of family violence among a sample of low-income fathers (N = 686) enrolled in a responsible fatherhood program. The program goals include increasing father involvement and economic stability and encouraging healthy relationships-with a focus on preventing intimate partner violence...
November 13, 2017: Social Work
https://www.readbyqxmd.com/read/29138824/genetic-mutational-testing-of-chinese-children-with-familial-hematuria-with-biopsy%C3%A2-proven-fsgs
#17
Yongzhen Li, Ying Wang, Qingnan He, Xiqiang Dang, Yan Cao, Xiaochuan Wu, Shuanghong Mo, Xiaoxie He, Zhuwen Yi
Focal segmental glomerulosclerosis (FSGS) is a pathological lesion rather than a disease, with a diverse etiology. FSGS may result from genetic and non‑genetic factors. FSGS is considered a podocyte disease due to the fact that in the majority of patients with proven‑FSGS, the lesion results from defects in the podocyte structure or function. However, FSGS does not result exclusively from podocyte‑associated genes, however also from other genes including collagen IV‑associated genes. Patients who carry the collagen type IVA3 chain (COL4A3) or COL4A4 mutations usually exhibit Alport Syndrome (AS), thin basement membrane neuropathy or familial hematuria (FH)...
November 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29138362/infant-neuromotor-development-and-childhood-problem-behavior
#18
Fadila Serdarevic, Akhgar Ghassabian, Tamara van Batenburg-Eddes, Emin Tahirovic, Tonya White, Vincent W V Jaddoe, Frank C Verhulst, Henning Tiemeier
BACKGROUND: Research of adults and school-aged children suggest a neurodevelopmental basis for psychiatric disorders. We examined whether infant neuromotor development predicted internalizing and externalizing problems in young children. METHODS: In Generation R, a population-based cohort in the Netherlands (2002-2006), trained research assistants evaluated the neuromotor development of 4006 infants aged 2 to 5 months by using an adapted version of Touwen's Neurodevelopmental Examination (tone, responses, and senses and other observations)...
November 14, 2017: Pediatrics
https://www.readbyqxmd.com/read/29136648/imprinting-alterations-in-sperm-may-not-significantly-influence-art-outcomes-and-imprinting-patterns-in-the-cord-blood-of-offspring
#19
Li Tang, Zichao Liu, Ruopeng Zhang, Cunmei Su, Wenjuan Yang, Youlin Yao, Shuhua Zhao
An increase in imprinting disorders in children conceived though assisted reproductive technologies (ARTs) has been the subject of several reports. The transmission of imprinting errors from the sperm of infertile fathers is believed to be a possible reason for the increased occurrence of these disorders. However, whether the imprinting alterations in sperm affect ART outcomes and the imprinting of offspring is unclear. In the current study, we analyzed the methylation of H19, SNRPN and KCNQ1OT1 by pyrosequencing sperm samples from 97 infertile patients and 31 proven fertile males as well as cord blood samples from 13 infantswho were conceived by infertile parents through intracytoplasmic sperm injection (ICSI) and 30 healthy newborns who were conceived naturally...
2017: PloS One
https://www.readbyqxmd.com/read/29135446/-cross-informant-agreement-between-parent-reported-and-adolescent-self-reported-quality-of-life-in-children-with-externalising-symptoms
#20
Dóra Szentiványi, József Halász, Lili O Horváth, Gergely Mészáros, Martina Miklós, Mónika Miklósi, Szabina Velo, Péter Vida, Judit Balázs
BACKGROUND: It is well-known phenomena both in clinical practice and research, that there is a discrepancy between the parents' and children's report about children's Quality of Life (QoL). The purpose of our research was to examine the differences in self and caregiver's proxy report of child's QoL. We also compared mothers', fathers' and other caregivers' reports of children's QoL. METHODS: Patients with externalizing symptoms in their history, aged 13-18 years were selected from the Vadaskert Child and Adolescent Psychiatry Hospital and Outpatient Clinic...
2017: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
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