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https://www.readbyqxmd.com/read/28913160/pancoast-tumor-approach-through-oesophagus
#1
Eritjan Tashi, Perlat Kapisyzi, Daniela Xhemalaj, Alma Andoni, Ilir Peposhi
Patient with Pancoast Tumor usually present in advanced stage of the disease which requires chemotherapy and radiotherapy as options of treatment. Histologic confirmation is a key for further treatment of these patients. Normally in bronchoscopy the lesion can't be visualised and in result making biopsy difficult to perform. Transthoracic biopsy through computed tomography poses anatomic difficulties and not always the pulmonary lesion can be reached. We report a case of pancoast tumor in a 68 year old male who presented with left arm pain and upper lobe increased density mass in chest x ray...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28900112/genomic-comparison-of-esophageal-squamous-cell-carcinoma-and-its-precursor-lesions-by-multi-region-whole-exome-sequencing
#2
Xi-Xi Chen, Qian Zhong, Yang Liu, Shu-Mei Yan, Zhang-Hua Chen, Shan-Zhao Jin, Tian-Liang Xia, Ruo-Yan Li, Ai-Jun Zhou, Zhe Su, Yu-Hua Huang, Qi-Tao Huang, Li-Yun Huang, Xing Zhang, Yan-Na Zhao, Jin-Ping Yun, Qiu-Liang Wu, Dong-Xin Lin, Fan Bai, Mu-Sheng Zeng
Esophageal squamous dysplasia is believed to be the precursor lesion of esophageal squamous cell carcinoma (ESCC); however, the genetic evolution from dysplasia to ESCC remains poorly understood. Here, we applied multi-region whole-exome sequencing to samples from two cohorts, 45 ESCC patients with matched dysplasia and carcinoma samples, and 13 tumor-free patients with only dysplasia samples. Our analysis reveals that dysplasia is heavily mutated and harbors most of the driver events reported in ESCC. Moreover, dysplasia is polyclonal, and remarkable heterogeneity is often observed between tumors and their neighboring dysplasia samples...
September 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28891710/the-use-of-a-thyroid-shield-for-intra-oral-anterior-oblique-occlusal-views-a-risk-based-approach
#3
Mark Worrall, Alison Menhinick, Donald J Thomson
OBJECTIVES: To estimate the radiation dose reduction to the thyroid for an anterior oblique occlusal view from the use of a thyroid shield, compare this to the variation in thyroid dose resulting from differences in examination positioning and discuss the additional considerations associated with the use of a thyroid shield before making a recommendation on their routine use for this examination. METHODS: Doses to the oral mucosa, the salivary glands, the thyroid, the extra-thoracic airways, the oesophagus and the lungs were directly measured for anterior oblique occlusal x-rays of a Rando phantom with and without a thyroid shield using strips of calibrated XRQA Gafchromic film...
September 11, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28881108/altered-oesophageal-mechanosensitivity-of-secondary-peristalsis-as-a-pathophysiological-marker-in-patients-with-globus-sensation
#4
Wei-Yi Lei, Jui-Sheng Hung, Tso-Tsai Liu, Chih-Hsun Yi, Chien-Lin Chen
OBJECTIVE: Secondary peristalsis is important for clearance of retained food bolus and refluxate from the oesophagus. We aimed to investigate whether patients with globus sensation have altered physiological characteristics of secondary peristalsis. DESIGN: Prospective case-controlled study. SETTING: Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan. PARTICIPANTS: 17 globus patients and 18 healthy controls...
September 7, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28880928/pseudempleurosoma-haywardi-sp-nov-monogenea-ancyrocephalidae-sensu-lato-bychowsky-nagibina-1968-an-endoparasite-of-croakers-teleostei-sciaenidae-from-indonesia
#5
Stefan Theisen, Harry W Palm, Sarah H Al-Jufaili, Sonja Kleinertz
An endoparasitic monogenean was identified for the first time from Indonesia. The oesophagus and anterior stomach of the croakers Nibea soldado (Lacépède) and Otolithes ruber (Bloch & Schneider) (n = 35 each) sampled from the South Java coast in May 2011 and Johnius amblycephalus (Bleeker) (n = 2) (all Sciaenidae) from Kedonganan fish market, South Bali coast, in November 2016, were infected with Pseudempleurosoma haywardi sp. nov. Prevalences in the first two croakers were 63% and 46%, respectively, and the two J...
2017: PloS One
https://www.readbyqxmd.com/read/28876648/prevalence-of-adenocarcinoma-of-the-oesophagus-in-two-teaching-hospitals-in-gauteng-province-south-africa
#6
K Singh, A Mannell, D Bizos, M Hale
BACKGROUND: Oesophageal carcinoma is the eighth most common cancer worldwide and sixth most common cause of cancer related mortality. The incidence of oesophageal adenocarcinoma has rapidly risen over the past decades; however squamous cell carcinoma of the oesophagus remains the most common worldwide. The prevalence of oesophageal carcinoma is high in South Africa and contributes significantly to the burden of disease. The prevalence of squamous cell carcinoma is greater than that of adenocarcinoma of the oesophagus but no recent local data is available...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28876577/surgical-burden-of-disease-at-a-regional-hospital-in-south-africa
#7
O Swart, J Pape, R Duvenage
BACKGROUND: There is limited published data describing the nature of surgical admissions at a regional level in the South African context. Worcester Hospital General Surgery has introduced an electronic online database to manage its surgical services. This study uses that database to evaluate the surgical burden of disease for the Cape Winelands East and Overberg districts of the Western Cape. METHOD: Admissions data were prospectively captured from February 2012 to January 2016, then retrospectively reviewed and classified into 5 types: (1) elective surgery/investigations (ESI); (2) trauma; (3) burns; (4) non-traumatic surgical emergencies (NTSE); (5) unplanned readmission within 30 days...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28876575/neonatal-surgery-a-study-of-two-years-at-nelson-mandela-academic-hospital-mthatha-eastern-cape
#8
A Delgado, A Cejas, D Bangasa
BACKGROUND: Advances in diagnostic techniques and perioperative care have greatly improved the outcome of neonatal surgery. Despite this, disparity still exists in the outcome of neonatal surgery between developed and developing countries. METHOD: We performed a prospective study of neonates admitted and treated due to surgical congenital diseases and other conditions in our hospital from April 2015 to April 2017. RESULTS: There were 19 (28,7%) females and 47 (70,3%) males in this group...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28876564/oesophageal-squamous-cell-cancer-in-a-south-african-tertiary-hospital-a-risk-factor-and-presentation-analysis
#9
E Loots, B Sartorius, T E Madiba, C J J Mulder, D L Clarke
BACKGROUND: Squamous carcinoma of the oesophagus (SCO) is the most common form of oesophageal cancer in South Africa (SA). Risk factors include male gender, smoking, alcohol consumption and low socio-economic status (SES). This study assessed the risk factors for SCO in KwaZulu-Natal. METHOD: Information on patients managed at Inkosi Albert Luthuli Central Hospital (IALCH), Durban, South Africa, between 1 October 2013 and 31 December 2014 was retrieved from a prospective database of Oesophageal Cancer (OC)...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28874836/oesophagus-symptom-perception-in-patients-with-nerd-do-nerves-matter
#10
Edoardo Savarino, Marco Della Coletta
No abstract text is available yet for this article.
September 6, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28871560/oesophageal-coins-invisible-on-chest-radiography-a-case-report
#11
Jin Takahashi, Takashi Shiga, Hiraku Funakoshi
BACKGROUND: Coins are made of metal, which is generally radiopaque, and so physicians often have the misconception that all coins are detectable by radiography. Here, we report a case of intentionally swallowed coins in the oesophagus of an adult; the coins could not be detected on chest radiography but were detected using computed tomography (CT). CASE PRESENTATION: A 46-year-old woman with a history of depression presented to the emergency department after an intentional medication overdose and ingestion of two Japanese 1-yen coins...
September 5, 2017: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28869413/severe-oesophageal-disease-and-its-associations-with-systemic-sclerosis
#12
Georgios P Karamanolis, Konstantinos Denaxas, Stylianos Panopoulos, Kalliopi-Vasiliki Bournia, Alexandra Zorbala, Dimitrios Kamberoglou, Dimitrios Schizas, Spiros D Ladas, Petros P Sfikakis
OBJECTIVES: Severe oesophageal disease in patients with systemic sclerosis (SSc), referred as scleroderma oesophagus, is characterised by ineffective or absent peristalsis along with hypotensive oesophagogastric junction (hEGJ). The associations between scleroderma oesophagus and different clinical and laboratory manifestations of SSc is still controversial. In this study we aimed to assess associations between scleroderma oesophagus, diagnosed by high resolution manometry (HRM), and other manifestations of disease...
August 30, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28867477/research-priority-setting-in-barrett-s-oesophagus-and-gastro-oesophageal-reflux-disease
#13
James Britton, Lisa Gadeke, Laurence Lovat, Shaheen Hamdy, Chris Hawkey, John McLaughlin, Yeng Ang
The incidence of gastro-oesophageal reflux disease and Barrett's oesophagus is increasing. Barrett's oesophagus is the main precursor to oesophageal adenocarcinoma, which has a poor prognosis. In view of the vast potential burden of these diseases on patients and health-care resources, there is a real need to define and focus research efforts. This priority setting exercise aimed to produce a list of the top ten uncertainties in the field that reflect the priorities of patients and health-care providers. We adopted the robust and transparent methodologies previously outlined by the James Lind Alliance...
August 31, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28865138/a-cost-effective-culture-system-for-the-in-vitro-assembly-maturation-and-stimulation-of-advanced-multilayered-multiculture-tubular-tissue-models
#14
Caroline Loy, Daniele Pezzoli, Gabriele Candiani, Diego Mantovani
The development of tubular engineered tissues is a challenging research area aiming to provide tissue substitutes but also in vitro models to test drugs, medical devices and even to study physiological and pathological processes. In this work, the design, fabrication, and validation of an original cost-effective tubular multilayered-tissue culture system (TMCS) were reported. By exploiting cellularised collagen gel as scaffold, a simple moulding technique and an endothelialisation step on a rotating system, TMCS allowed to easily prepare in 48 hours, trilayered arterial wall models with finely organised cellular composition and to mature them for two weeks without any need of manipulation...
September 2, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28862125/solitary-adrenal-metastases-from-breast-invasive-ductal-carcinoma
#15
Cezar Stroescu, Iulian Gilca, Dragoş Chirita, Radu Poenaru, Ana Puşcaşu, Diana Pescaru, Adelina Birceanu, Cornelia Niţipir, Narcis Copcă
The usual neoplastic dissease involving suprarenal glands are adrenal metastaes. The majority of suprarenal metastatic disease arise from lung cancer, followed by the stomach and colon cancer, oesophagus, the liver/bile ducts cancer and renal cell carcinoma. Invasive mammary carcinoma usually spreads to the bones, lungs, lymph nodes, liver and the brain. Adrenal gland metastases from invasive no special type carcinoma represents an extremly low rate number of cases. We discuss about a 66 year old patient who presented with a solitary adrenal metastases from triple negative breast invasive carcinoma...
July 2017: Chirurgia
https://www.readbyqxmd.com/read/28860646/metaplasia-tissue-injury-adaptation-and-a-precursor-to-the-dysplasia-cancer-sequence
#16
REVIEW
Veronique Giroux, Anil K Rustgi
Metaplasia is the replacement of one differentiated somatic cell type with another differentiated somatic cell type in the same tissue. Typically, metaplasia is triggered by environmental stimuli, which may act in concert with the deleterious effects of microorganisms and inflammation. The cell of origin for intestinal metaplasia in the oesophagus and stomach and for pancreatic acinar-ductal metaplasia has been posited through genetic mouse models and lineage tracing but has not been identified in other types of metaplasia, such as squamous metaplasia...
September 1, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28857160/cancer-risk-of-lichen-planus-a-cohort-study-of-13-100-women-in-finland
#17
P M Halonen, M I Jakobsson, M A O Heikinheimo, A E Riska, M V Gissler, E I Pukkala
The association between lichen planus (LP) and cancer has been under debate for decades. We studied the connection via population-based Finnish register data. All women with the diagnosis of LP (n=13,100) were identified from the Finnish Hospital Discharge Registry from 1969-2012. These patients were linked with subsequent cancer diagnoses from the Finnish Cancer Registry until 2014. Standardized Incidence Ratios (SIRs) were counted for different cancers by dividing the observed numbers of cancers by expected numbers, which were based on national cancer incidence rates...
August 31, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28856431/morphological-and-molecular-characteristics-of-six-sarcocystis-spp-from-red-deer-cervus-elaphus-in-spain-including-sarcocystis-cervicanis-and-three-new-species
#18
Bjørn Gjerde, Mónica Luzón, José María Alunda, Concepción de la Fuente
Samples of muscle tissue from the diaphragm, oesophagus and/or heart of eight adult red deer (Cervus elaphus hispanicus) from the Quintos de Mora Park in Toledo, Central Spain, were screened for sarcocysts by means of the compression method. From positive samples, individual sarcocysts were excised and examined in wet mounts under a light microscope (LM) in order to study their basic morphology before being preserved for molecular studies. In all red deer examined, only microscopic sarcocysts were found. Those in the diaphragm and oesophagus were spindle-shaped and about 1 × 0...
August 30, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28855951/migrating-pleural-plaque-in-a-patient-with-asbestos-induced-pleural-disease-a-case-report
#19
Christian Eisenhawer, Michael K Felten, Thomas Hager, Mikhail Gronostayskiy, Philipp Bruners, Andrea Tannapfel, Thomas Kraus
BACKGROUND: Health surveillance of formerly asbestos exposed individuals focus on early detection of asbestos related diseases, such as lung fibrosis (asbestosis), pleural plaques, mesothelioma and lung cancer in particular. One main concern is the early and clear identification of lesions with a high risk of malignant changes and their undelayed clinical work-up. False positive results may lead to unnecessary and often painful diagnostic interventions, which create high costs when applied to a large cohort and also may discredit the whole program...
2017: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/28853590/pedunculated-well-differentiated-liposarcoma-of-the-oesophagus-mimicking-giant-fibrovascular-polyp
#20
A S Mehdorn, F Schmidt, K Steinestel, E Wardelmann, B Greulich, D Palmes, N Senninger
We present a rare case of a big oesophageal liposarcoma causing dysphagia and weight loss in a 75-year-old patient. Endoscopically, a pedunculated lesion with subtotal obstruction of the oesophageal lumen had been detected and thoracoabdominal oesophageal resection with gastric sleeve reconstruction was performed. Surprisingly, a liposarcoma of the oesophagus was revealed on histopathological analysis, showing MDM2 overexpression. Oncological follow-up has been uneventful and the patient remains in good clinical shape at 15 months after surgery...
September 2017: Annals of the Royal College of Surgeons of England
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