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https://www.readbyqxmd.com/read/29149260/an-aorto-oesophageal-fistula-caused-by-a-fish-bone-resulting-in-an-accidental-discovery-of-an-invasive-adenocarcinoma-in-the-lung
#1
Bao Long Zhang, Ji Ning Sun, Na Na Liu, Fu Zhi Cao
An aorto-oesophageal fistula is a rare, life-threatening complication caused by sharp foreign bodies in the oesophagus. We report an aorto-oesophageal fistula in the inferior segment of thoracic oesophagus caused by a fish bone. Multiplanar reconstruction of computed tomography and computed tomography angiography demonstrated that a foreign body had pierced from the left posterior wall of the oesophagus into the descending aortic wall. These computed tomography images can help radiologists make the correct diagnosis and provide precise evidence for clinicians to perform a timely surgical intervention...
November 15, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29145901/-food-bolus-obstruction-of-the-oesophagus-or-ingestion-of-a-foreign-body-what-should-you-do
#2
P R Oosterwijk, M A C Meijssen
A food bolus obstruction of the oesophagus and foreign body ingestion are frequently encountered in common clinical practice. There is currently no guideline in the Netherlands for management of these problems. We present two cases to illustrate how these can be managed in line with European and American guidelines. The first patient was a 36-year-old female with total obstruction of the oesophagus by a food bolus. Biopsies taken following endoscopic removal showed eosinophilic infiltration of the mucosa and a subsequent diagnosis of eosinophilic oesophagitis...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29141663/quality-assurance-of-the-scope-1-trial-in-oesophageal-radiotherapy
#3
Lucy Wills, Rhydian Maggs, Geraint Lewis, Gareth Jones, Lisette Nixon, John Staffurth, Tom Crosby
BACKGROUND: SCOPE 1 was the first UK based multi-centre trial involving radiotherapy of the oesophagus. A comprehensive radiotherapy trials quality assurance programme was launched with two main aims: 1. To assist centres, where needed, to adapt their radiotherapy techniques in order to achieve protocol compliance and thereby enable their participation in the trial. 2. To support the trial's clinical outcomes by ensuring the consistent planning and delivery of radiotherapy across all participating centres...
November 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29138285/expression-and-prognostic-significance-of-human-epidermal-growth-factor-receptors-1-2-and-3-in-oesophageal-and-gastric-adenocarcinomas-preneoadjuvant-and-postneoadjuvant-treatment
#4
Charlotta Hedner, David Borg, Björn Nodin, Emelie Karnevi, Karin Jirström, Jakob Eberhard
AIMS: Neoadjuvant treatment has now become the standard of care for oesophageal and gastric cancer. The aim of this study was to investigate the influence of neoadjuvant therapy on the expression of human epidermal growth factor receptor 1 (HER1/EGFR), HER2 and HER3, in oesophageal and gastric adenocarcinoma. METHODS: Immunohistochemical expression of EGFR, HER2 and HER3 was examined and compared in pretreatment biopsies, post-treatment surgical resection specimens and metastases in a retrospective cohort of 166 patients with adenocarcinoma of the oesophagus or stomach...
November 14, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29133313/site-specific-cancer-mortality-inequalities-by-employment-and-occupational-groups-a-cohort-study-among-belgian-adults-2001-2011
#5
Katrien Vanthomme, Laura Van den Borre, Hadewijch Vandenheede, Paulien Hagedoorn, Sylvie Gadeyne
OBJECTIVE: This study probes into site-specific cancer mortality inequalities by employment and occupational group among Belgians, adjusted for other indicators of socioeconomic (SE) position. DESIGN: This cohort study is based on record linkage between the Belgian censuses of 1991 and 2001 and register data on emigration and mortality for 01/10/2001 to 31/12/2011. SETTING: Belgium. PARTICIPANTS: The study population contains all Belgians within the economically active age (25-65 years) at the census of 1991...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29128908/cetuximab-tpf-radiotherapy-in-oesophageal-cancer
#6
Maria Alsina, Fernando Rivera, Francisco Javier Ramos, Maica Galán, Rafael López, Pilar García-Alfonso, José Enrique Alés-Martinez, Bernardo Queralt, Antonio Antón, Alfredo Carrato, Cristina Grávalos, Maria José Méndez-Vidal, Carlos López, Inmaculada Ruiz de Mena, Josep Tabernero, Jordi Giralt, Enrique Aranda
BACKGROUND: Pre-operative chemoradiotherapy using a 5-fluorouracil (5-FU)/cisplatin backbone is widely used to improve surgical outcomes in locoregional oesophageal cancer patients, despite a non-negligible failure rate. OBJECTIVE: We evaluated intensification of this approach to improve patient outcomes by adding cetuximab to induction 5-FU/cisplatin/docetaxel (TPF) and to chemoradiotherapy in a phase II study. PATIENTS AND METHODS: Between November 2006 and April 2009, 50 patients with stage II-IVa squamous cell carcinoma (SCC) or adenocarcinoma of the oesophagus or gastro-oesophageal junction initiated three TPF/cetuximab cycles...
November 11, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/29127751/-the-benefit-of-new-angiogenesis-bevacizumab-and-aflibercept-inhibitors-for-multiple-angiomatosis-therapy-a%C3%A2-case-report
#7
Dagmar Brančíková, Lenka Ostřížková, Zdeněk Adam, Tomáš Nebeský, Luděk Pour, Zdeněk Král, Jiří Mayer
Angiomatosis is a term for multiple, gradually proliferating hemangiomas (angiodysplasia), affecting multiple organs or tissues at the same time. We describe a 12-year course of treatment of a patient with multiple hemangiomas located in the abdomen, retroperitoneum, oesophagus, mediastinum and also in vertebrae. The diagnosis was made in 2005 within probatory laparotomy, at the age of 28 years. The treatment was commenced right after making the diagnosis with interferon α. Due to its adverse effects (fatigue, anorexia), the use of interferon α was limited to the first year, after which the interferon dose was gradually being reduced until it was discontinued completely...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29127130/eosinophilic-oesophagitis-and-coeliac-disease-is-there-an-association
#8
Ana Margarida Vaz, Antonio Jesus Cadilla, Diamantino Sousa, Horácio Guerreiro
A 25-year-old man was seen in outpatient clinic for progressive solid food dysphagia. He was already medicated with a proton pump inhibitor with no improvement. His blood tests showed a slight microcytic anaemia and peripheral eosinophilia. The oesophago-gastro-duodenoscopy showed longitudinal furrows in the distal two-thirds of the oesophagus and a concentric distal stenosis. The biopsies taken showed eosinophilic infiltrates consistent with eosinophilic oesophagitis. There was no improvement with topical fluticasone, so the patient was started on a systemic corticosteroid with resolution of dysphagia and of the oesophageal stenosis...
November 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29125080/-organ-sparing-treatment-in-oesophagus-cancer-feasible-and-safe
#9
B J Noordman, B P L Wijnhoven, S M Lagarde, M C W Spaander, R Valkema, J J B van Lanschot
In many countries, neoadjuvant chemoradiotherapy (nCRT) plus surgery is standard treatment for resectable oesophageal cancer. After nCRT, up to 30% of all patients have no residual disease in the resection specimen. Consequently, an active surveillance approach, in which patients undergo frequent clinical investigations after nCRT instead of standard oesophagectomy, is increasingly applied in selected patients. Here, we describe outcomes for three patients who underwent active surveillance. A 63-year old woman was considered unfit for surgery after nCRT...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29123580/the-impact-of-age-and-sex-on-the-occurrence-of-pathology-in-the-wall-of-the-upper-gastrointestinal-tract
#10
Przemysław Dyrla, Jerzy Gil, Stanisław Niemczyk, Marek Saracyn, Krzysztof Kosik, Sebastian Czarkowski, Arkadiusz Lubas
Introduction: The growing incidence of gastrointestinal diseases forces to improve both imaging techniques and the identification of the population with a greater risk of a disease. Identification of lesions located inside the wall of intestinal tract or in close proximity often was not possible using endoscopy or computed tomography. Aim: The study was a retrospective evaluation of the occurrence of submucosal lesions (SML) and thickened wall (TW) of the upper gastrointestinal tract (UGIT) depending on age and sex...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29123575/systemic-sclerosis-and-the-gastrointestinal-tract
#11
REVIEW
Irena Walecka
Systemic sclerosis (SSc) is an autoimmunological disease of unknown origin with complex pathogenesis and multiple organ involvement. It is characterised by vascular and immunological abnormalities leading to fibrosis of the skin and internal organs. It is a rather rare disease with a prevalence of around 20 per 100,000. The disease results in heterogeneous clinical findings and different courses. Systemic sclerosis usually begins with the onset of Raynaud's phenomenon (RP), followed by skin sclerosis and internal organ involvement, although it may appear synchronously with RP...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29109876/debut-of-gastroesophageal-reflux-concomitant-with-administration-of-sublingual-immunotherapy
#12
Jacob Juel
Gastroesophageal reflux disease (GORD) is an often debilitating condition characterised by retrograde flow of content from stomach into the oesophagus, where the low pH of the stomach acid irritates the mucosa of the oesophagus. The most dominant symptoms in GORD are pyrosis, regurgitation, and dysphagia. Sublingual immunotherapy (SLIT) was first described in 1986. Following this description, the use has greatly increased in the treatment of allergic rhinitis, as an alternative to subcutaneously administered immunotherapy...
2017: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29108538/-upper-abdominal-pain-caused-by-oesophageal-perforation
#13
EDITORIAL
Bastian Neesgaard, Anne-Sophie Sejling, Lene Arguimbau Ostenfeld-Møller
Boerhaave's syndrome or spontaneous oesophageal perforation is associated with significant mortality de-pending on time of diagnosis and initiation of treatment. However, the diagnosis is often delayed, as the condition mimics more frequent causes of chest- and abdominal pain. This case report describes a patient with severe upper ab-dominal and back pain following ructus in an effort to loosen a piece of candy stuck in the oesophagus. The case demon-strates, that Boerhaave's syndrome should always be con-sidered in patients presenting with acute chest- or upper abdominal pain...
November 6, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29102995/selecting-ph-cut-offs-for-the-safe-verification-of-nasogastric-feeding-tube-placement-a-decision-analytical-modelling-approach
#14
Melody Zhifang Ni, Jeremy R Huddy, Oliver H Priest, Sisse Olsen, Lawrence D Phillips, Patrick M M Bossuyt, George B Hanna
OBJECTIVES: The existing British National Patient Safety Agency (NPSA) safety guideline recommends testing the pH of nasogastric (NG) tube aspirates. Feeding is considered safe if a pH of 5.5 or lower has been observed; otherwise chest X-rays are recommended. Our previous research found that at 5.5, the pH test lacks sensitivity towards oesophageal placements, a major risk identified by feeding experts. The aim of this research is to use a decision analytic modelling approach to systematically assess the safety of the pH test under cut-offs 1-9...
November 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/29097867/dysphagia-thinking-outside-the-box
#15
REVIEW
Hamish Philpott, Mayur Garg, Dunya Tomic, Smrithya Balasubramanian, Rami Sweis
Dysphagia is a common symptom that is important to recognise and appropriately manage, given that causes include life threatening oesophageal neoplasia, oropharyngeal dysfunction, the risk of aspiration, as well as chronic disabling gastroesophageal reflux (GORD). The predominant causes of dysphagia varies between cohorts depending on the interplay between genetic predisposition and environmental risk factors, and is changing with time. Currently in white Caucasian societies adopting a western lifestyle, obesity is common and thus associated gastroesophageal reflux disease is increasingly diagnosed...
October 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29097432/endoscopic-ultrasound-fine-needle-aspiration-by-experienced-pulmonologists-a-cusum-analysis
#16
Paul Leong, Sheetal Deshpande, Louis B Irving, Philip G Bardin, Michael W Farmer, Barton R Jennings, Daniel P Steinfort
Endobronchial ultrasound transbronchial needle aspiration (EBUS TBNA) is an established, minimally invasive way to sample intrathoracic abnormalities. The EBUS scope can be passed into the oesophagus to perform endoscopic ultrasound with bronchoscope-guided fine-needle aspiration (EUS-B-FNA). In cases of suspected lung cancer, a combination of the two techniques is now recommended by consensus guidelines. EBUS TBNA is usually performed by pulmonologists; however, the learning curve for EUS-B-FNA, which may be performed during the same procedure, has not been described...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29097074/a-phase-ii-toxicity-end-point-trial-icorg-99-09-of-accelerated-dose-escalated-hypofractionated-radiation-in-non-small-cell-lung-cancer
#17
D N Cagney, P G Thirion, M T Dunne, C Fleming, D Fitzpatrick, C M O'Shea, M A Finn, S O'Sullivan, C Booth, C D Collins, S J Buckney, A Shannon, J G Armstrong
AIMS: The objective of this phase II clinical trial was to prospectively evaluate the safety and efficacy of accelerated hypofractionated three-dimensional conformal radiation therapy (3DCRT) in localised non-resectable/non-operable non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Sixty patients with stage I-III NSCLC were enrolled in a prospective single-arm All Ireland Co-operative Oncology Research Group (ICORG 99-09) toxicity end point phase II trial...
October 30, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29092016/oesophageal-mucosal-blood-flow-changes-after-thoracic-endovascular-stent-graft-implantation-using-a-novel-sensor-probe
#18
Shintaro Katahira, Shunsuke Kawamoto, Naoki Masaki, Yukihiro Hayatsu, Tadao Matsunaga, Yoichi Haga, Yoshikatsu Saiki
OBJECTIVES: Secondary aorto-oesophageal fistula is a rare, lethal complication occurring after thoracic endovascular aneurysmal repair. The cause of secondary aorto-oesophageal fistula is unknown, but a reduction in local oesophageal mucosal blood flow (OMBF) may be a basis for such a devastating sequela. Our study aims to develop a novel blood flow sensor probe to detect changes in OMBF after thoracic stent graft implantation in an experimental swine model. METHODS: A novel laser Doppler flowmetry sensor probe incorporating an optical fibre sensor within a nasogastric tube was developed using microelectromechanical system technology...
October 30, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29090740/inflammatory-polyp-trapped-in-the-oesophagus-of-a-cat
#19
P Sebastian, E Dominguez, I Espada, L Fresno, R Novellas
No abstract text is available yet for this article.
November 1, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29080344/bile-acids-and-cancer-direct-and-environmental-dependent-effects
#20
Agostino Di Ciaula, David Q-H Wang, Emilio Molina-Molina, Raquel Lunardi Baccetto, Giuseppe Calamita, Vincenzo O Palmieri, Piero Portincasa
Bile acids (BAs) regulate the absorption of fat-soluble vitamins, cholesterol and lipids but have also a key role as singalling molecules and in the modulation of epithelial cell proliferation, gene expression and metabolism. These homeostatic pathways, when disrupted, are able to promote local inflammation, systemic metabolic disorders and, ultimately, cancer. The effect of hydrophobic BAs, in particular, can be linked with cancer in several digestive (mainly oesophagus, stomach, liver, pancreas, biliary tract, colon) and extra-digestive organs (i...
October 28, 2017: Annals of Hepatology
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