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https://www.readbyqxmd.com/read/28088205/quercetin-improves-macrophage-reverse-cholesterol-transport-in-apolipoprotein-e-deficient-mice-fed-a-high-fat-diet
#1
Yingjie Cui, Pengbo Hou, Fahui Li, Qinghua Liu, Shucun Qin, Guanghai Zhou, Xuelian Xu, Yanhong Si, Shoudong Guo
BACKGROUND: Quercetin, one of the most widely distributed flavonoids in plants, has been demonstrated to reduce hyperlipidaemia and atherosclerotic lesion formation. Reverse cholesterol transport (RCT) plays a crucial role in exporting cholesterol from peripheral cells, which is one mechanism utilized in the prevention and treatment of atherosclerosis. The aim of this study is to investigate whether quercetin reduces lipid accumulation by improving RCT in vivo. METHODS: Apolipoprotein E-deficient mice fed a high-fat diet were used to investigate the effect of quercetin on RCT by an isotope tracing method, and the underlying mechanisms were clarified by molecular techniques...
January 14, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28087981/humanized-chondroitinase-abc-sensitizes-glioblastoma-cells-to-temozolomide
#2
Alena Cristina Jaime-Ramirez, Nina Dmitrieva, Ji Young Yoo, Yeshavanth Banasavadi-Siddegowda, Jianying Zhang, Theresa Relation, Chelsea Bolyard-Blessing, Jeffrey Wojton, Balveen Kaur
INTRODUCTION: Malignant gliomas (GBMs) are extremely aggressive and have a median survival of approximately 15 months. Current treatment modalities, which include surgical resection, radiation and chemotherapy, have done little to prolong the lives of GBM patients. Chondroitin sulfate proteoglycans (CSPG) are critical for cell-cell and cell-extra cellular matrix (ECM) interactions and are implicated in glioma growth and invasion. Chondroitinase (Chase) ABC is a bacterial enzyme that cleaves chondroitin sulfate disaccharide chains from CSPGs in the tumor ECM...
January 14, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28085946/ocli-023-a-novel-pyrimidine-compound-suppresses-osteoclastogenesis-in-vitro-and-alveolar-bone-resorption-in-vivo
#3
Hye Jung Ihn, Taeho Lee, Ju Ang Kim, Doohyun Lee, Nam Doo Kim, Hong-In Shin, Yong Chul Bae, Eui Kyun Park
An abnormal increase in osteoclast differentiation and activation results in various bone-resorptive diseases, including periodontitis, rheumatoid arthritis, and osteoporosis. Chemical compounds containing pyrimidine ring have been shown to regulate a variety of biological processes. Therefore, in order to identify an antiresorptive agent, we synthesized a series of pyrimidine ring-containing chemical compounds, and found that OCLI-023 suppressed the differentiation and activation of osteoclasts in vitro. OCLI-023 directly inhibited receptor activator of nuclear factor-κB ligand (RANKL)-induced differentiation of bone marrow macrophages into osteoclasts, without a cytotoxic response...
2017: PloS One
https://www.readbyqxmd.com/read/28085876/inference-of-transmission-network-structure-from-hiv-phylogenetic-trees
#4
Federica Giardina, Ethan Obie Romero-Severson, Jan Albert, Tom Britton, Thomas Leitner
Phylogenetic inference is an attractive means to reconstruct transmission histories and epidemics. However, there is not a perfect correspondence between transmission history and virus phylogeny. Both node height and topological differences may occur, depending on the interaction between within-host evolutionary dynamics and between-host transmission patterns. To investigate these interactions, we added a within-host evolutionary model in epidemiological simulations and examined if the resulting phylogeny could recover different types of contact networks...
January 13, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28085203/extensive-recent-secondary-contacts-between-four-european-white-oak-species
#5
Thibault Leroy, Camille Roux, Laure Villate, Catherine Bodénès, Jonathan Romiguier, Jorge A P Paiva, Carole Dossat, Jean-Marc Aury, Christophe Plomion, Antoine Kremer
Historical trajectories of tree species during the late Quaternary have been well reconstructed through genetic and palaeobotanical studies. However, many congeneric tree species are interfertile, and the timing and contribution of introgression to species divergence during their evolutionary history remains largely unknown. We quantified past and current gene flow events between four morphologically divergent oak species (Quercus petraea, Q. robur, Q. pyrenaica, Q. pubescens), by two independent inference methods: diffusion approximation to the joint frequency spectrum (∂a∂i) and approximate Bayesian computation (ABC)...
January 13, 2017: New Phytologist
https://www.readbyqxmd.com/read/28085053/socio-environmental-and-hematological-profile-of-landfill-residents-s%C3%A3-o-jorge-landfill-sao-paulo-brazil
#6
Vivianni Palmeira Wanderley, Fernando Luiz Affonso Fonseca, André Vala Quiaios, José Nuno Domingues, Susana Paixão, João Figueiredo, Ana Ferreira, Cleonice de Almeida Pinto, Odair Ramos da Silva, Rogério Alvarenga, Amaury Machi Junior, Eriane Justo Luiz Savóia, Rodrigo Daminello Raimundo
We are experiencing an unprecedented urbanization process that, alongside physical, social and economic developments, has been having a significant impact on a population's health. Due to the increase in pollution, violence and poverty, our modern cities no longer ensure a good quality of life so they become unhealthy environments. This study aims to assess the effect of social, environmental and economic factors on the hematologic profile of residents of Santo André's landfill. In particular, we will assess the effect of social, economic, and environmental factors on current and potential disease markers obtained from hematological tests...
January 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28084799/examining-clinics-for-children-with-autism-the-autism-translating-to-treatments-at3-study
#7
Stephen Bent, Katherine Dang, Felicia Widjaja, Brittany Lawton, Nazneen, Robert L Hendren
OBJECTIVES: Certain clinical providers specialize in providing complementary and integrative medicine (CIM) therapies for children with autism spectrum disorder (ASD). Because many of these providers and their patients/families have reported substantial improvement, the authors developed an online platform to carefully examine these clinical practices. The initial goal was to examine the feasibility of prospective data collection in this setting. The larger goals were to characterize the tests and treatments used in these clinics; examine associations between specific treatments, biomarkers, and improved outcomes; and identify promising treatments for future study...
January 13, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28084193/type-i-protein-secretion-deceptively-simple-yet-with-a-wide-range-of-mechanistic-variability-across-the-family
#8
I Barry Holland, Sandra Peherstorfer, Kerstin Kanonenberg, Michael Lenders, Sven Reimann, Lutz Schmitt
A very large type I polypeptide begins to reel out from a ribosome; minutes later, the still unidentifiable polypeptide, largely lacking secondary structure, is now in some cases a thousand or more residues longer. Synthesis of the final hundred C-terminal residues commences. This includes the identity code, the secretion signal within the last 50 amino acids, designed to dock with a waiting ATP binding cassette (ABC) transporter. What happens next is the subject of this review, with the main, but not the only focus on hemolysin HlyA, an RTX protein toxin secreted by the type I system...
December 2016: EcoSal Plus
https://www.readbyqxmd.com/read/28083868/motor-impairment-in-children-born-preterm-assessment-with-the-movement-abc-2
#9
Sally Jary
No abstract text is available yet for this article.
January 13, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28083808/heat-acclimation-of-bifidobacterium-longum-and-proteomic-changes-behind-it
#10
Hongbin Wang, Yu Li, Yong Zhang, Qinglong Xi, Yueting Cao, Fuping Lu
Bifidobacterium is an important probiotic bacterium and extensively applied to functional food. Its survival is strongly affected by the heat-shock process during manufacture. Acclimation is thought to be able to enhance Bifidobacterium's resistance to heat stress; however, so far little is known about the protein expression changes underlying the adaptation process. In this study, the appropriate acclimation temperature for Bifidobacterium longum was determined as 43 °C, and 2-dimensional gel electrophoresis-based proteomic analysis was performed to reveal the protein changes in expression levels behind heat acclimation...
January 12, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28082225/rigidifying-flexible-sites-an-approach-to-improve-stability-of-chondroitinase-abc-i
#11
Asma Kheirollahi, Khosro Khajeh, Abolfazl Golestani
The stability of chondroitin ABC lyase I (cABC I) at physiological temperature is one of the current obstacles to its clinical application. In this study, we used a protein engineering approach; rigidify flexible sites, to improve stability of cABC I. B-factor analysis showed a flexible loop at the N-terminal domain of cABC I which may be involved in its thermal instability and five residues in this region were replaced with proline. Thermal inactivation and thermal denaturation analysis revealed that Glu138Pro mutation increased half-life and Tm of enzyme, respectively...
January 9, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28081202/characterization-and-functional-analysis-of-five-mads-box-b-class-genes-related-to-floral-organ-identification-in-tagetes-erecta
#12
Ye Ai, Chunling Zhang, Yalin Sun, Weining Wang, Yanhong He, Manzhu Bao
According to the floral organ development ABC model, B class genes specify petal and stamen identification. In order to study the function of B class genes in flower development of Tagetes erecta, five MADS-box B class genes were identified and their expression and putative functions were studied. Sequence comparisons and phylogenetic analyses indicated that there were one PI-like gene-TePI, two euAP3-like genes-TeAP3-1 and TeAP3-2, and two TM6-like genes-TeTM6-1 and TeTM6-2 in T. erecta. Strong expression levels of these genes were detected in stamens of the disk florets, but little or no expression was detected in bracts, receptacles or vegetative organs...
2017: PloS One
https://www.readbyqxmd.com/read/28079635/influences-of-age-obesity-and-adverse-drug-effects-on-balance-and-mobility-testing-scores-in-ambulatory-older-adults
#13
Eric Anson, Elizabeth Thompson, Brian L Odle, John Jeka, Zachary F Walls, Peter C Panus
BACKGROUND AND PURPOSE: The adverse effects of drugs may influence results on tests of mobility and balance, but the drug-specific impact is not identified when using these tests. We propose that a quantitative drug index (QDI) will assist in assessing fall risk based on these tests, when combined with other fall risk variables. METHODS: Fifty-seven community-dwelling older adults who could walk independently on a treadmill and had Mini-Mental State Examination (MMSE) scores equal to or greater than 24 participated...
January 10, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28078124/advanced-biliary-tract-cancer-clinical-outcomes-with-abc-02-regimen-and-analysis-of-prognostic-factors-in-a-tertiary-care-center-in-the-united-states
#14
Rishi Agarwal, Arun Sendilnathan, Nabeela Iffat Siddiqi, Shuchi Gulati, Abhimanyu Ghose, Changchun Xie, Olugbenga Olanrele Olowokure
BACKGROUND: Gemcitabine plus cisplatin (GC) is currently the standard regimen for advanced biliary tract cancers (BTC) based on the outcomes in ABC-02 trial. Multiple factors can affect outcomes in these patients. This retrospective review evaluates the University of Cincinnati experience with GC in advanced intrahepatic (IHC)/extrahepatic cholangiocarcinoma (EHC) and gall bladder carcinoma (GBC). METHODS: In this study approved by University of Cincinnati IRB, retrospective analysis of advanced BTC patients seen between 01/2008 and 01/2015 was done...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28073050/genome-wide-identification-of-atp-binding-cassette-abc-transporters-and-their-roles-in-response-to-polycyclic-aromatic-hydrocarbons-pahs-in-the-copepod-paracyclopina-nana
#15
Chang-Bum Jeong, Duck-Hyun Kim, Hye-Min Kang, Young Hwan Lee, Hui-Su Kim, Il-Chan Kim, Jae-Seong Lee
The ATP-binding cassette (ABC) protein superfamily is one of the largest gene families and is highly conserved in all domains. The ABC proteins play roles in several biological processes, including multi-xenobiotic resistance (MXR), by functioning as transporters in the cellular membrane. They also mediate the cellular efflux of a wide range of substrates against concentration gradients. In this study, 37 ABC genes belonging to eight distinct subfamilies were identified in the marine copepod Paracyclopina nana and annotated based on a phylogenetic analysis...
December 30, 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/28073005/simultaneous-inhibition-of-pi3k%C3%AE-and-pi3k%C3%AE-induces-abc-dlbcl-regression-by-blocking-bcr-dependent-and-independent-activation-of-nf-%C3%AE%C2%BAb-and-akt
#16
Juliane Paul, Maurice Soujon, Antje M Wengner, Sabine Zitzmann-Kolbe, Andrea Sturz, Katja Haike, Koh Hui Keng Magdalene, Sze Huey Tan, Martin Lange, Soo Yong Tan, Dominik Mumberg, Soon Thye Lim, Karl Ziegelbauer, Ningshu Liu
Compared with follicular lymphoma, high PI3Kα expression was more prevalent in diffuse large B cell lymphoma (DLBCL), although both tumor types expressed substantial PI3Kδ. Simultaneous inhibition of PI3Kα and PI3Kδ dramatically enhanced the anti-tumor profile in ABC-DLBCL models compared with selective inhibition of PI3Kδ, PI3Kα, or BTK. The anti-tumor activity was associated with suppression of p-AKT and a mechanism of blocking nuclear factor-κB activation driven by CD79(mut), CARD11(mut), TNFAIP3(mut), or MYD88(mut)...
January 9, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28069938/crystal-structure-and-mechanistic-basis-of-a-functional-homolog-of-the-antigen-transporter-tap
#17
Anne Nöll, Christoph Thomas, Valentina Herbring, Tina Zollmann, Katja Barth, Ahmad Reza Mehdipour, Thomas M Tomasiak, Stefan Brüchert, Benesh Joseph, Rupert Abele, Vincent Oliéric, Meitian Wang, Kay Diederichs, Gerhard Hummer, Robert M Stroud, Klaas M Pos, Robert Tampé
ABC transporters form one of the largest protein superfamilies in all domains of life, catalyzing the movement of diverse substrates across membranes. In this key position, ABC transporters can mediate multidrug resistance in cancer therapy and their dysfunction is linked to various diseases. Here, we describe the 2.7-Å X-ray structure of heterodimeric Thermus thermophilus multidrug resistance proteins A and B (TmrAB), which not only shares structural homology with the antigen translocation complex TAP, but is also able to restore antigen processing in human TAP-deficient cells...
January 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28069632/a-few-sequence-polymorphisms-among-isolates-of-maize-bushy-stunt-phytoplasma-associate-with-organ-proliferation-symptoms-of-infected-maize-plants
#18
Zigmunds Orlovskis, Maria Cristina Canale, Mindia Haryono, João Roberto Spotti Lopes, Chih-Horng Kuo, Saskia A Hogenhout
BACKGROUND AND AIMS: Maize bushy stunt phytoplasma (MBSP) is a bacterial pathogen of maize (Zea mays L.) across Latin America. MBSP belongs to the 16SrI-B sub-group within the genus 'Candidatus Phytoplasma'. MBSP and its insect vector Dalbulus maidis (Hemiptera: Cicadellidae) are restricted to maize; both are thought to have coevolved with maize during its domestication from a teosinte-like ancestor. MBSP-infected maize plants show a diversity of symptoms. and it is likely that MBSP is under strong selection for increased virulence and insect transmission on maize hybrids that are widely grown in Brazil...
January 9, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28069035/fbw7-regulates-apoptosis-in-activated-b-cell-like-diffuse-large-b-cell-lymphoma-by-targeting-stat3-for-ubiquitylation-and-degradation
#19
Su Yao, Fangping Xu, Yu Chen, Yan Ge, Fen Zhang, Huijie Huang, Li Li, Danyi Lin, Xinlan Luo, Jie Xu, Donglan Luo, Xiaolan Zhu, Yanhui Liu
BACKGROUND: The ubiquitin-ligase Fbw7 acts as a tumor suppressor, targeting lots of proto-oncogenes for proteolysis. However, the exact role of Fbw7 in diffuse large B-cell lymphoma (DLBCL) development remains unclear. METHODS: We evaluated Fbw7 expression in patient samples of DLBCL using immunohistochemical staining. The effect of Fbw7 overexpression on cell viability and apoptosis was investigated using activated B-cell (ABC) like DLBCL cell lines. The mechanism of Fbw7 activity in DLBCL was investigated using immunoprecipitation, ubiquitination, western blot and qualitative analyses...
January 10, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28068262/associated-aneurysmal-bone-cyst-and-cemento-osseous-dysplasia-a-case-report-and-review-of-the-literature
#20
Willian Pecin Jacomacci, João Paulo Veloso Perdigão, Vanessa Cristina Veltrini, Gustavo Jacobucci Farah, Elen Souza Tolentino, Lilian Cristina Vessoni Iwaki, Liogi Iwaki Filho
The purpose of this case report is to describe a previously unpublished association between focal cemento-osseous dysplasia (FCOD) and an aneurysmal bone cyst (ABC) and review the literature with regard to associated benign fibro-osseous lesions and cysts. A 41-year-old woman without a history of trauma presented with asymptomatic swelling in the right side of the mandible. Radiographs of the region revealed a unilocular radiolucent area with radiopaque foci. After aspiration of the lesion was positive for serosanguineous fluid, complete excision of the lesion was performed...
January 2017: General Dentistry
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