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https://www.readbyqxmd.com/read/29331750/phosphoinositide-3-kinase-inhibitors-in-advanced-breast-cancer-a-systematic-review-and-meta-analysis
#1
REVIEW
Jacques Raphael, Danielle Desautels, Kathleen I Pritchard, Ekaterina Petkova, Prakeshkumar S Shah
Phosphoinositide 3-kinase (PI3K) inhibitors may overcome drug resistance and improve advanced breast cancer (ABC) outcomes. We conducted a systematic review and meta-analysis to assess the efficacy and safety of adding a PI3K inhibitor to the standard of care (SOC) treatment in ABC. The electronic databases Ovid, PubMed, Cochrane Central Register of Controlled Trials and Embase, were searched for relevant randomised trials. Pooled hazard ratios (HRs) for progression-free survival (PFS) and pooled risk ratios (RRs) for objective response rates (ORRs), disease control rates (DCRs) and toxicity were meta-analysed using the Mantel-Haenszel method and generic inverse variance...
January 10, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29331420/dacomitinib-antagonizes-multidrug-resistance-mdr-in-cancer-cells-by-inhibiting-the-efflux-activity-of-abcb1-and-abcg2-transporters
#2
Ying-Fang Fan, Wei Zhang, Leli Zeng, Zi-Ning Lei, Chao-Yun Cai, Pranav Gupta, Dong-Hua Yang, Qingbin Cui, Zuo-Dong Qin, Zhe-Sheng Chen, Louis D Trombetta
The development of multidrug resistance (MDR) to chemotherapy remains a major challenge in the treatment of cancer. Numerous mechanisms have been recognized that cause MDR, but one of the most important mechanisms is overexpression of adenosine triphosphate (ATP)-binding cassette (ABC) transporters, through which the efflux of various anticancer drugs against their concentration gradients is powered by ATP. In recent years, small molecular tyrosine kinase inhibitors (TKIs) have been developed for treatment in various human cancers overexpressing epidermal growth factor receptor (EGFR)...
January 10, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29330817/effect-of-levofloxacin-pazufloxacin-enrofloxacin-and-meloxicam-on-the-immunolocalization-of-abcg-2-transporter-protein-in-rabbit-retina
#3
Adil Mehraj Khan, Satyavan Rampal, Naresh Kumar Sood
Adenosine triphosphate-binding cassette (ABC) sub-family G member-2 (ABCG-2) is a transporter protein, implicated for multi-drug efflux from tissues. This study evaluated the effect of fluoroquinolones; levofloxacin, pazufloxacin and enrofloxacin, and non-steroidal anti-inflammatory drug, meloxicam; on the immunolocalization of ABCG-2 transporter protein of rabbit retinas. Thirty-two male rabbits were randomly divided in to eight groups. Control group was gavaged, 2% benzyl alcohol in 5% dextrose since these chemicals are excipients of the drug preparations used in the treatment groups of this study...
January 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29328931/biostimulation-and-bioaugmentation-of-native-microbial-community-accelerated-bioremediation-of-oil-refinery-sludge
#4
Ajoy Roy, Avishek Dutta, Siddhartha Pal, Abhishek Gupta, Jayeeta Sarkar, Ananya Chatterjee, Anumeha Saha, Poulomi Sarkar, Pinaki Sar, Sufia K Kazy
Scope for developing an engineered bioremediation strategy for the treatment of hydrocarbon-rich petroleum refinery waste was investigated through biostimulation and bioaugmentation approaches. Enhanced (46-55%) total petroleum hydrocarbon (TPH) attenuation was achieved through phosphate, nitrate or nitrate+phosphate amendment in the sludge with increased (upto 12%) abundance of fermentative, hydrocarbon degrading, sulfate-reducing, CO2-assimilating and methanogenic microorganisms (Bacillus, Coprothermobacter, Rhodobacter, Pseudomonas, Achromobacter, Desulfitobacter, Desulfosporosinus, T78, Methanobacterium, Methanosaeta, etc)...
January 3, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29328096/approximate-bayesian-computation-techniques-for-optical-characterization-of-nanoparticle-clusters
#5
Ozan Burak Ericok, Ali Taylan Cemgil, Hakan Erturk
Characterization of nanoparticle aggregates from observed scattered light leads to a highly complex inverse problem. Even the forward model is so complex that it prohibits the use of classical likelihood-based inference methods. In this study, we compare four so-called likelihood-free methods based on approximate Bayesian computation (ABC) that requires only numeric simulation of the forward model without the need of evaluating a likelihood. In particular, rejection, Markov chain Monte Carlo, population Monte Carlo, and adaptive population Monte Carlo (APMC) are compared in terms of accuracy...
January 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29327946/posttranscriptional-regulation-of-human-antigen-r-by-mir-133b-enhances-docetaxel-cytotoxicity-through-the-inhibition-of-atp-binding-cassette-subfamily-g-member-2-in-prostate-cancer-cells
#6
Hui Liu, Xiaolong Song, Junqing Hou, Zhenhua Zhao, Junkai Chang
Docetaxel (DTX)-based chemotherapy is a first-line therapy in patients with castration-resistant prostate cancer. However, development of DTX resistance remains a challenge in cancer treatment. miRNAs have been shown to be involved in drug resistance in tumors. Nevertheless, little is known about the function and detailed molecular mechanism of miR-133b in DTX resistance of prostate cancer cells. The current study showed that miR-133b was downregulated, while human antigen R (HuR) was upregulated in prostate cancer cells...
January 12, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29326062/functional-effects-of-an-interpenetrating-polymer-network-on-articular-cartilage-mechanical-properties
#7
Janne Ta Mäkelä, Benjamin G Cooper, Rami K Korhonen, Mark W Grinstaff, Brian D Snyder
OBJECTIVE: Depletion of glycosaminoglycans (GAGs) and degradation of collagen network are early hallmarks of osteoarthritis. Currently, there are no chondroprotective therapies that mitigate the loss of GAGs or effectively restore the collagen network. Recently, a novel polymeric cartilage supplement was described that forms a charged interpenetrating polymer network (IPN) reconstituting the hydrophilic properties of the extracellular matrix. To investigate the mechanism by which this hydrophilic IPN improves articular cartilage material properties, a finite element (FE) model is used to evaluate the IPN's effect on the fibrillar collagen network, nonfibrillar matrix, and interstitial fluid flow...
January 8, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29324743/an-enhanced-artificial-bee-colony-algorithm-eabc-for-solving-dispatching-of-hydro-thermal-system-dhts-problem
#8
Yi Yu, Yonggang Wu, Binqi Hu, Xinglong Liu
The dispatching of hydro-thermal system is a nonlinear programming problem with multiple constraints and high dimensions and the solution techniques of the model have been a hotspot in research. Based on the advantage of that the artificial bee colony algorithm (ABC) can efficiently solve the high-dimensional problem, an improved artificial bee colony algorithm has been proposed to solve DHTS problem in this paper. The improvements of the proposed algorithm include two aspects. On one hand, local search can be guided in efficiency by the information of the global optimal solution and its gradient in each generation...
2018: PloS One
https://www.readbyqxmd.com/read/29324255/aberrant-autistic-and-food-related-behaviors-in-adults-with-prader-willi-syndrome-the-comparison-between-young-adults-and-adults
#9
Hiroyuki Ogata, Hiroshi Ihara, Masao Gito, Masayuki Sayama, Nobuyuki Murakami, Tadayuki Ayabe, Yuji Oto, Toshiro Nagai, Kazutaka Shimoda
This study aims to explore the differences of age as well as genotype in regards to the severity of behavioral symptoms in Prader-Willi syndrome (PWS), with emphasis on the comparison between youngadults and adults.The Food Related Problem Questionnaire (FRPQ), the Aberrant Behavior Checklist Japanese Version (ABC-J), and the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS) were administered to 46 PWS patients, including 33 young adults (ages 18-28) and 13 adults(ages 30-45). To examine the differences between young adults and adults, Mann-Whitney U tests were conducted...
January 8, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29322491/influence-of-prehospital-function-and-strength-on-outcomes-of-critically-ill-older-adults
#10
D Clark Files, Rebecca Neiberg, Julia Rushing, Peter E Morris, Michael P Young, Hilsa Ayonayon, Tamara Harris, Anne Newman, Susan Rubin, Eric Shiroma, Denise Houston, Michael E Miller, Stephen B Kritchevsky
OBJECTIVES: To understand the influence of prehospital physical function and strength on clinical outcomes of critically ill older adults. DESIGN: Secondary analysis of prospective cohort study. SETTING: Health, Aging and Body Composition (Health ABC) Study. PARTICIPANTS: Of 3,075 older adult Health ABC participants, we identified 575 (60% white, 61% male, mean age 79) with prehospital function or grip strength measurements within 2 years of an intensive care unit stay...
January 11, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29321340/retrospective-methods-analysis-of-semiautomated-intracerebral-hemorrhage-volume-quantification-from-a-selection-of-the-stich-ii-cohort-early-surgery-versus-initial-conservative-treatment-in-patients-with-spontaneous-supratentorial-lobar-intracerebral-haematomas
#11
Mark D Haley, Barbara A Gregson, W Andrew Mould, Daniel F Hanley, Alexander David Mendelow
BACKGROUND AND PURPOSE: The ABC/2 method for calculating intracerebral hemorrhage (ICH) volume has been well validated. However, the formula, derived from the volume of an ellipse, assumes the shape of ICH is elliptical. We sought to compare the agreement of the ABC/2 formula with other methods through retrospective analysis of a selection of the STICH II cohort (Early Surgery Versus Initial Conservative Treatment in Patients With Spontaneous Supratentorial Lobar Intracerebral Haematomas)...
January 10, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29320481/architecture-of-a-channel-forming-o-antigen-polysaccharide-abc-transporter
#12
Yunchen Bi, Evan Mann, Chris Whitfield, Jochen Zimmer
O-antigens are cell surface polysaccharides of many Gram-negative pathogens that aid in escaping innate immune responses. A widespread O-antigen biosynthesis mechanism involves the synthesis of the lipid-anchored polymer on the cytosolic face of the inner membrane, followed by transport to the periplasmic side where it is ligated to the lipid A core to complete a lipopolysaccharide molecule. In this pathway, transport to the periplasm is mediated by an ATP-binding cassette (ABC) transporter, called Wzm-Wzt...
January 10, 2018: Nature
https://www.readbyqxmd.com/read/29318719/crystal-structures-of-mglb-2-tp0684-a-topologically-variant-d-glucose-binding-protein-from-treponema-pallidum-reveal-a-ligand-induced-conformational-change
#13
Chad A Brautigam, Ranjit K Deka, Wei Z Liu, Michael V Norgard
Previously, we determined the crystal structure of apo-TpMglB-2, a D-glucose-binding component of a putative ABC transporter from the syphilis spirochete Treponema pallidum. The protein had an unusual topology for this class of proteins, raising the question of whether the D-glucose-binding mode would be different in TpMglB-2. Here, we present the crystal structures of a variant of TpMglB-2 with and without D-glucose bound. The structures demonstrate that, despite its aberrant topology, the protein undergoes conformational changes and binds D-glucose similarly to other Mgl-type proteins, likely facilitating D-glucose uptake in T...
January 10, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29316419/lps-transport-flipping-out-over-msba
#14
Bradley J Voss, M Stephen Trent
Lipopolysaccharide synthesis and transport pathways are attractive targets for the development of new antimicrobial therapeutics. The ABC (ATP Binding Cassette) transporter MsbA has been recently described as employing a 'trap and flip' mechanism of lipopolysaccharide transport. This represents a novel mechanism amongst known lipid ABC transporters.
January 8, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29316260/genetic-origin-and-dispersal-of-the-invasive-soybean-aphid-inferred-from-population-genetic-analysis-and-approximate-bayesian-computation
#15
Fang Fang, Jing Chen, Li-Yun Jiang, Yan-Hua Qu, Ge-Xia Qiao
Biological invasion is considered one of the most important global environmental problems. Knowledge of the source and dispersal routes of invasion could facilitate the eradication and control of invasive species. Soybean aphid, Aphis glycines Matsumura, is one of the most destructive soybean pests. For effective management of this pest, we conducted genetic analyses and approximate Bayesian computation (ABC) analysis to determine the origins and dispersal of the aphid species, as well as the source of its invasion in the USA, using eight microsatellite loci and the mitochondrial cytochrome c oxidase subunit I (COI) gene...
January 9, 2018: Integrative Zoology
https://www.readbyqxmd.com/read/29314726/the-complete-genome-sequence-of-vibrio-aestuarianus-w-40-reveals-virulence-factor-genes
#16
Xiaojin Xu, Lixing Huang, Yongquan Su, Qingpi Yan
Vibrio aestuarianus is an opportunistic environmental pathogen that has been associated with epidemics in cultured shrimp Penaeus vannamei. Hepatopancreas microsporidian (HPM) and monodon slow growth syndrome (MSGS) have been reported in cultured P. vannamei. In this study, we sequenced and assembled the whole genome of V. aestuarianus strain W-40, a strain that was originally isolated from the intestines of an infected P. vannamei. The genome of V. aestuarianus strain W-40 contains two circular chromosomes of 483,7307 bp with a 46...
January 3, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29311076/crystal-structure-of-nisi-in-a-lipid-free-form-the-nisin-immunity-protein-from-lactococcus-lactis
#17
Jin Hee Jeong, Sung Chul Ha
Nisin is a lantibiotic, a family of polypeptides containing lanthionine with antimicrobial activity. Nisin-producing microorganisms require immunity proteins for self-protection from nisin itself. Lactococcus lactis, a microorganism that synthesizes nisin, has an integral NisFEG ABC transporter and NisI lipoprotein that function in the nisin immunity. Here, we present the crystal structure of the full length of NisI22-C, a lipid-free form of NisI, determined at 1.9 Å resolution. Similar to the NMR structures of N- and C-terminal domain of NisI, NisI22-C is composed of N- and C-terminal domains, both of which display a fold similar to that found in SpaI, a lipoprotein with immunity against subtilin in Bacillus subtilis The full length structure of NisI22-c reveals a large and deep cleft by the interdomain association, one side of which is occupied by the residues important for immunity...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29311061/enhanced-efflux-pump-activity-in-old-candida-glabrata
#18
Somanon Bhattacharya, Bettina C Fries
The effect of replicative aging on antifungal resistance in Candida glabrata was investigated. Our studies demonstrate significantly increased transcription of ABC transporters as well as efflux pump activity in old compared to young C. glabrata cells of a fluconazole sensitive and resistant strain. In addition, higher tolerance to killing by micafungin and amphotericin B was noted and is associated with higher transcription of glucan synthase gene FKS1 and lower ergosterol content in older cells.
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29310586/available-bed-sided-comprehensive-abc-score-to-a-diagnosis-of-methicillin-resistant-staphylococcus-aureus-infection-a-derivation-and-validation-study
#19
Nori Yoshioka, Matsuo Deguchi, Hideharu Hagiya, Hisao Yoshida, Norihisa Yamamoto, Shoji Hashimoto, Yukihiro Akeda, Kazunori Tomono
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) infections continue to be a leading problem in health care facilities worldwide. METHODS: This single-center retrospective cohort study consisted of a derivation phase and a validation phase. The derivation phase included all patients admitted to Osaka University Hospital between May 2010 and April 2011. We proposed a provisional available, bed-sided, comprehensive (ABC) score, and evaluated its accuracy using the clinical diagnosis as a reference...
January 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29309257/the-slc22-transporter-family-a-paradigm-for-the-impact-of-drug-transporters-on-metabolic-pathways-signaling-and-disease
#20
Sanjay K Nigam
The SLC22 transporter family consists of more than two dozen members, which are expressed in the kidney, the liver, and other tissues. Evolutionary analysis indicates that SLC22 transporters fall into at least six subfamilies: OAT (organic anion transporter), OAT-like, OAT-related, OCT (organic cation transporter), OCTN (organic cation/carnitine transporter), and OCT/OCTN-related. Some-including OAT1 [SLC22A6 or NKT (novel kidney transporter)] and OAT3 (SLC22A8), as well as OCT1 (SLC22A1) and OCT2 (SLC22A2)-are widely studied drug transporters...
January 6, 2018: Annual Review of Pharmacology and Toxicology
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