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https://www.readbyqxmd.com/read/28531793/disrupted-body-image-and-pregnancy-related-lumbopelvic-pain-a-preliminary-investigation
#1
Benedict M Wand, Rhianne L Elliott, Abbey E Sawyer, Rory Spence, Darren J Beales, Peter B O'Sullivan, Anne J Smith, William Gibson
BACKGROUND: Recent investigations have suggested that disrupted body-image may contribute to the lumbopelvic pain experience. The changes in body shape and size associated with pregnancy suggest that pregnancy-related lumbopelvic pain might be a problem in which alterations in body-image are particularly relevant. OBJECTIVES: To investigate if self-reported body-image is related to lumbopelvic pain status in women during pregnancy and explore the factors that might contribute to changes in body-image in women experiencing pregnancy-related lumbopelvic pain...
May 17, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28531276/impact-of-vitamin-a-and-carotenoids-on-the-risk-of-tuberculosis-progression
#2
Omowunmi Aibana, Molly F Franke, Chuan-Chin Huang, Jerome T Galea, Roger Calderon, Zibiao Zhang, Mercedes C Becerra, Emily R Smith, Alayne G Ronnenberg, Carmen Contreras, Rosa Yataco, Leonid Lecca, Megan B Murray
Background: Low and deficient levels of vitamin A are common in low and middle income countries where tuberculosis (TB) burden is high. We assessed the impact of baseline levels of vitamins A and carotenoids on TB disease risk. Methods: We conducted a case-control study nested within a longitudinal cohort of household contacts of pulmonary TB cases in Lima, Peru. We defined cases as HIV-negative household contacts with blood samples who developed TB disease at least 15 days after enrollment of index patient...
May 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28531094/cost-effectiveness-of-a-community-exercise-and-nutrition-program-for-older-adults-texercise-select
#3
Olufolake Odufuwa Akanni, Matthew Lee Smith, Marcia G Ory
The wide-spread dissemination of evidence-based programs that can improve health outcomes among older populations often requires an understanding of factors influencing community adoption of such programs. One such program is Texercise Select, a community-based health promotion program previously shown to improve functional health, physical activity, nutritional habits and quality of the life among older adults. This paper assesses the cost-effectiveness of Texercise Select in the context of supportive environments to facilitate its delivery and statewide sustainability...
May 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28530858/customizing-alarm-limits-based-on-specific-needs-of-patients
#4
Maria Cvach, Melanie Kitchens, Kevin Smith, Patricia Harris, Marilyn Neder Flack
No abstract text is available yet for this article.
May 2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/28530811/multi-targeted-imidazoles-potential-therapeutic-leads-for-alzheimer-s-and-other-neurodegenerative-diseases
#5
Anne-Sophie Cornec, Ludovica Monti, Jane Kovalevich, Vishruti Makani, Michael J James, Krishna G Vijayendran, Killian Oukoloff, Yuemang Yao, Virginia M-Y Lee, John Q Trojanowski, Amos B Smith Iii, Kurt R Brunden, Carlo Ballatore
Alzheimer's disease (AD) is a complex, multifactorial disease in which different neuropathological mechanisms are likely involved, including those associated with pathological tau and Aβ species, as well as neuroinflammation. In this context, the development of single multi-targeted therapeutics directed against two or more disease mechanisms could be advantageous. Starting from a series of 1,5-diarylimidazoles with microtubule (MT)-stabilizing activity and structural similarities with known NSAIDs, we conducted structure-activity relationship studies that led to the identification of multi-targeted prototypes with activities as MT-stabilizing agents and/or inhibitors of the cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) pathways...
May 22, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28530804/characterization-of-growth-patterns-of-nanoscale-organic-films-on-carbon-electrodes-by-surface-enhanced-raman-spectroscopy
#6
Mustafa Supur, Scott R Smith, Richard L McCreery
Electrochemical deposition of aromatic organic molecules by reduction of diazonium reagents enables formation of molecular layers with sufficient integrity for use in molecular electronic junctions of interest to microelectronics. Characterization of organic films with thicknesses in the 1-10 nm range is difficult with Raman spectroscopy, since most molecular structures of electronic interest have Raman cross sections which are too small to observe as either thin films on solid electrodes or within intact molecular junctions...
May 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28530659/actin-cortex-architecture-regulates-cell-surface-tension
#7
Priyamvada Chugh, Andrew G Clark, Matthew B Smith, Davide A D Cassani, Kai Dierkes, Anan Ragab, Philippe P Roux, Guillaume Charras, Guillaume Salbreux, Ewa K Paluch
Animal cell shape is largely determined by the cortex, a thin actin network underlying the plasma membrane in which myosin-driven stresses generate contractile tension. Tension gradients result in local contractions and drive cell deformations. Previous cortical tension regulation studies have focused on myosin motors. Here, we show that cortical actin network architecture is equally important. First, we observe that actin cortex thickness and tension are inversely correlated during cell-cycle progression. We then show that the actin filament length regulators CFL1, CAPZB and DIAPH1 regulate mitotic cortex thickness and find that both increasing and decreasing thickness decreases tension in mitosis...
May 22, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28530657/normal-and-cancerous-mammary-stem-cells-evade-interferon-induced-constraint-through-the-mir-199a-lcor-axis
#8
Toni Celià-Terrassa, Daniel D Liu, Abrar Choudhury, Xiang Hang, Yong Wei, Jose Zamalloa, Raymundo Alfaro-Aco, Rumela Chakrabarti, Yi-Zhou Jiang, Bong Ihn Koh, Heath A Smith, Christina DeCoste, Jun-Jing Li, Zhi-Ming Shao, Yibin Kang
Tumour-initiating cells, or cancer stem cells (CSCs), possess stem-cell-like properties observed in normal adult tissue stem cells. Normal and cancerous stem cells may therefore share regulatory mechanisms for maintaining self-renewing capacity and resisting differentiation elicited by cell-intrinsic or microenvironmental cues. Here, we show that miR-199a promotes stem cell properties in mammary stem cells and breast CSCs by directly repressing nuclear receptor corepressor LCOR, which primes interferon (IFN) responses...
May 22, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28530639/calcium-binding-protein-s100a4-confers-mesenchymal-progenitor-cell-fibrogenicity-in-idiopathic-pulmonary-fibrosis
#9
Hong Xia, Adam Gilbertsen, Jeremy Herrera, Emilian Racila, Karen Smith, Mark Peterson, Timothy Griffin, Alexey Benyumov, Libang Yang, Peter B Bitterman, Craig A Henke
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a prevalence of 1 million persons worldwide. The fibrosis spreads from affected alveoli into contiguous alveoli and leads to death by asphyxiation. We previously discovered that the IPF lung harbors fibrogenic mesenchymal progenitor cells (MPCs) that serve as a cell of origin for disease-mediating myofibroblasts. In a prior genomewide transcriptional analysis, we found that IPF MPCs displayed increased expression of S100 calcium-binding A4 (S100A4), a protein linked to cancer cell proliferation and invasiveness...
May 22, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28530478/validity-of-a-linear-velocity-transducer-for-testing-maximum-vertical-jumps
#10
Alejandro Pérez-Castilla, Belén Feriche, Slobodan Jaric, Paulino Padial, Amador García-Ramos
This study aimed to examine the validity of mechanical variables obtained by a linear velocity transducer from the unconstrained and constrained squat jump (SJ). Twenty-three men were tested on the unconstrained SJ and the SJ constrained by a Smith machine. Maximum values of force, velocity, and power were simultaneously recorded both by a linear velocity transducer attached to a bar of mass of 17, 30, 45, 60 and 75 kg and by a force plate. Linear velocity transducer generally overestimated the outcomes measured as compared to the force plate, particularly in unconstrained SJ...
May 22, 2017: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/28530114/patients-and-healthcare-professionals-perceptions-of-self-management-support-interactions-systematic-review-and-qualitative-synthesis
#11
Marika Franklin, Sophie Lewis, Karen Willis, Helen Bourke-Taylor, Lorraine Smith
Objective To review studies examining the experience of self-management support in patient-provider interactions and the shaping of goals through interactions. Methods We undertook a systematic review and thematic synthesis of the qualitative literature. We searched six databases (2004-2015) for published studies on the provision of self-management support in one-to-one, face-to-face, patient-provider interactions for obesity, type 2 diabetes mellitus and chronic obstructive pulmonary disease, with 14 articles meeting inclusion criteria...
January 1, 2017: Chronic Illness
https://www.readbyqxmd.com/read/28529410/quality-of-life-in-patients-with-intermittent-claudication
#12
A E Harwood, J P Totty, E Broadbent, G E Smith, I C Chetter
BACKGROUND: Intermittent claudication (IC) is a common condition that causes pain in the lower limbs when walking and has been shown to severely impact the quality of life (QoL) of patients. The QoL is therefore often regarded as an important measure in clinical trials investigating intermittent claudication. To date, no consensus exits on the type of life questionnaire to be used. This review aims to examine the QoL questionnaires used in trials investigating peripheral arterial disease (PAD)...
2017: Gefässchirurgie: Zeitschrift Für Vaskuläre und Endovaskuläre Chirurgie
https://www.readbyqxmd.com/read/28528910/the-management-of-soft-tissue-tumours-of-the-abdominal-wall
#13
REVIEW
H G Smith, D Tzanis, C Messiou, C Benson, J A van der Hage, M Fiore, S Bonvalot, A J Hayes
BACKGROUND: Soft tissue tumours of the abdominal wall account for approximately 10% of all soft tissue tumours. Tumours at this site comprise a heterogeneous group of pathologies with distinct clinical behaviours and responses to treatment. The management of these tumours has largely been extrapolated from studies of soft tissue tumours at other sites. This review aims to summarise the existing data relating to abdominal wall tumours and suggest principles for managing soft tissue tumours at this site...
May 6, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28528899/effect-of-professional-society-recommendations-on-women-s-desire-for-a-routine-pelvic-examination
#14
George F Sawaya, Karen K Smith-McCune, Steven E Gregorich, Michelle Moghadassi, Miriam Kuppermann
BACKGROUND: The American College of Physicians strongly recommends against performing pelvic examinations in asymptomatic, nonpregnant women, citing evidence of harm (false-positive testing, unnecessary surgery) and no evidence of benefit. In contrast, the American Congress of Obstetricians and Gynecologists recommends pelvic examinations in asymptomatic women beginning at age 21 years, citing expert opinion. OBJECTIVE: We sought to evaluate if providing women with professional societies' conflicting statements about pelvic examinations (recommendations and rationales) would influence their desire for a routine examination...
May 18, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28528804/an-interactive-videogame-for-arm-and-hand-exercise-in-people-with-parkinson-s-disease-a-randomized-controlled-trial
#15
Natalie E Allen, Jooeun Song, Serene S Paul, Stuart Smith, Jonathan O'Duffy, Matthew Schmidt, Rachelle Love, Catherine Sherrington, Colleen G Canning
INTRODUCTION: People with Parkinson's disease (PD) have difficulty performing upper extremity (UE) activities. The aim of this study was to investigate if exergames targeting the UE improve arm and hand activities and impairments and to establish the acceptability and feasibility of these games in people with PD. METHODS: Two tablet-based exergames were developed which were controlled with finger movements or unimanual whole arm movements. Participants with PD were randomized to an exergame (n = 19) or control (n = 19) group...
May 15, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28528752/account-for-primary-health-care-when-indexing-access-and-quality
#16
Felicity Goodyear-Smith, Chris van Weel
No abstract text is available yet for this article.
May 18, 2017: Lancet
https://www.readbyqxmd.com/read/28528623/organizational-perspectives-of-nurse-executives-in-15-hospitals-on-the-impact-and-effectiveness-of-rapid-response-teams
#17
Patricia L Smith, Jean McSweeney
BACKGROUND: Many hospitals use rapid response teams (RRTs) to respond to deteriorating patients, but it remains unclear what organizations actually monitor. Understanding what organizations value in an RRT may help clarify measurement choices. Interviews were conducted to determine how organizational leaders perceived and evaluated their hospitals' RRTs. METHODS: The study used a descriptive, qualitative design. Participants were nurse executives and key informants in 300- to 500-bed hospitals in the south-central United States and were recruited using purposive and snowball sampling...
June 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28528587/persistent-infections-support-maintenance-of-a-coronavirus-in-a-population-of-australian-bats-myotis-macropus
#18
J Jeong, C S Smith, A J Peel, R K Plowright, D H Kerlin, J McBroom, H McCallum
Understanding viral transmission dynamics within populations of reservoir hosts can facilitate greater knowledge of the spillover of emerging infectious diseases. While bat-borne viruses are of concern to public health, investigations into their dynamics have been limited by a lack of longitudinal data from individual bats. Here, we examine capture-mark-recapture (CMR) data from a species of Australian bat (Myotis macropus) infected with a putative novel Alphacoronavirus within a Bayesian framework. Then, we developed epidemic models to estimate the effect of persistently infectious individuals (which shed viruses for extensive periods) on the probability of viral maintenance within the study population...
May 22, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28528564/authors-response-to-letter-long-term-noninvasive-ventilation-in-muscular-dystrophy-need-planning-of-future-services
#19
W Kinnear, J Colt, L Watson, P Smith, L Johnson, S Burrows, M Sovani, A Khanna, P Maddison, A Wills
No abstract text is available yet for this article.
May 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28528444/assembly-and-egress-of-an-alphaherpesvirus-clockwork
#20
Gregory A Smith
All viruses produce infectious particles that possess some degree of stability in the extracellular environment yet disassemble upon cell contact and entry. For the alphaherpesviruses, which include many neuroinvasive viruses of mammals, these metastable virions consist of an icosahedral capsid surrounded by a protein matrix (referred to as the tegument) and a lipid envelope studded with glycoproteins. Whereas the capsid of these viruses is a rigid structure encasing the DNA genome, the tegument and envelope are dynamic assemblies that orchestrate a sequential series of events that ends with the delivery of the genome into the nucleus...
2017: Advances in Anatomy, Embryology, and Cell Biology
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