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https://www.readbyqxmd.com/read/30006984/the-cost-of-facing-fear-visual-working-memory-is-impaired-for-faces-expressing-fear
#1
Kim M Curby, Stephen D Smith, Denise Moerel, Amy Dyson
Previous research has identified numerous factors affecting the capacity and accuracy of visual working memory (VWM). One potentially important factor is the emotionality of the stimuli to be encoded and held in VWM. We often must hold in VWM information that is emotionally charged, but much is still unknown about how the emotionality of stimuli impacts VWM performance. In the current research, we performed four studies examining the impact of fearful facial expressions on VWM for faces. Fearful expressions were found to produce a consistent cost to VWM performance...
July 13, 2018: British Journal of Psychology
https://www.readbyqxmd.com/read/30006953/remote-nucleophilic-allylation-by-allylrhodium-chain-walking
#2
Alistair Groves, Jose I Martínez, Joshua J Smith, Hon Wai Lam
Metal migration through a carbon chain is a versatile method for achieving remote functionalization. However, almost all known examples involve the overall net migration of alkylmetal species. Here, we report that allylrhodium species obtained from hydrorhodation of 1,3-dienes undergo chain walking toward esters, amides, or (hetero)arenes over distances of up to eight methylene units. The final, more highly conjugated allylrhodium species undergo nucleophilic allylation with aldehydes and an imine to give Z-homoallylic alcohols and amines, respectively...
July 13, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/30006917/long-term-follow-up-of-nailfold-videocapillaroscopic-changes-in-dermatomyositis-versus-systemic-sclerosis-patients
#3
C Pizzorni, M Cutolo, A Sulli, B Ruaro, A C Trombetta, G Ferrari, G Pesce, V Smith, S Paolino
To identify nailfold videocapillaroscopy (NVC) changes in patients with dermatomyositis (DM) during a 3-year follow-up and to compare the NVC findings between DM and systemic sclerosis (SSc) patients at their first visit. Retrospective study of 24 DM and 24 SSc patients, matched for age and disease duration at first NVC. Capillaroscopic patterns/scores and clinical parameters had been yearly assessed. Nineteen out of 24 DM patients (79%) showed a NVC "scleroderma-like pattern." No statistically significant variation of all the capillaroscopic scores was observed during the 3-year follow-up...
July 13, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/30006510/sustainable-syntheses-of-jerantinines-a-e-and-structural-characterisation-of-the-jerantinine-tubulin-complex-at-the-colchicine-binding-site
#4
Christopher J Smedley, Paul A Stanley, Mohannad E Qazzaz, Andrea E Prota, Natacha Olieric, Hilary Collins, Harry Eastman, Andrew S Barrow, Kuan-Hon Lim, Toh-Seok Kam, Brian J Smith, Hendrika M Duivenvoorden, Belinda S Parker, Tracey D Bradshaw, Michel O Steinmetz, John E Moses
The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad spectrum anticancer activity. The natural supply of these precious metabolites has been significantly disrupted due to the inclusion of T. corymbosa on the endangered list of threatened species by the International Union for Conservation of Nature. This report describes the asymmetric syntheses of (-)-jerantinines A and E from sustainably sourced (-)-tabersonine, using a straight-forward and robust biomimetic approach...
July 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30006431/evolving-treatment-paradigm-in-the-treatment-of-locally-advanced-rectal-cancer
#5
REVIEW
Clayton A Smith, Lisa A Kachnic
Locally advanced rectal cancer (LARC) carries higher risks of local and distant recurrence when treated with surgical resection alone. Multiple treatment strategies have been investigated to reduce recurrence risk and improve survival. Currently, there are 3 primary strategies for managing LARC: (1) preoperative long-course radiotherapy (RT) combined with radiosensitizing chemotherapy, which is better tolerated than postoperative chemoradiotherapy and provides tumor downstaging and improved pathologic complete response (pCR), followed by postoperative chemotherapy; (2) preoperative short-course RT alone as an alternative strategy for reducing the risk of local recurrence, followed by adjuvant postoperative chemotherapy; and (3) total neoadjuvant therapy with induction chemotherapy followed by chemoradiotherapy to improve pCR and reduce the difficulty of delivering chemotherapy in the postoperative setting...
July 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/30006135/ablation-of-carotenoid-cleavage-enzymes-bco1-and-bco2-induced-hepatic-steatosis-by-altering-the-farnesoid-x-receptor-mir-34a-sirtuin-1-pathway
#6
Ji Ye Lim, Chun Liu, Kang-Quan Hu, Donald E Smith, Xiang-Dong Wang
β-Carotene-15, 15'-oxygenase (BCO1) and β-carotene-9', 10'-oxygenase (BCO2) are essential enzymes in carotenoid metabolism. While BCO1/BCO2 polymorphisms have been associated with alterations to human and animal carotenoid levels, experimental studies have suggested that BCO1 and BCO2 may have specific physiological functions beyond the cleavage of carotenoids. In the present study, we investigated the effect of ablation of both BCO1/BCO2 in the development of non-alcoholic fatty liver disease (NAFLD) and its underlying molecular mechanism(s)...
July 10, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/30006114/increased-pulmonary-systemic-pulse-pressure-ratio-is-associated-with-increased-mortality-in-group-1-pulmonary-hypertension
#7
Benjamin K Ruth, Kenneth C Bilchick, Manu M Mysore, Hunter Mwansa, William C Harding, Younghoon Kwon, Jamie L W Kennedy, Jeremy A Mazurek, Andrew D Mihalek, LaVone A Smith, Eliany Mejia-Lopez, Alex M Parker, Timothy S Welch, Sula Mazimba
BACKGROUND: Pulmonary arterial hypertension (PAH) is characterised by remodelling of the pulmonary vasculature leading to right ventricular (RV) failure. The failing RV, through interventricular uncoupling, deleteriously impacts the left ventricle and overall cardiac efficiency. We hypothesised that the ratio of the pulmonary artery pulse pressure to the systemic pulse pressure ("pulmonary-systemic pulse pressure ratio", or PS-PPR) would be associated with mortality in PAH. METHODS: We conducted a retrospective analysis of 262 patients in the National Institute of Health Primary Pulmonary Hypertension Registry (NIH-PPH)...
June 21, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/30006094/o-085-is-progressive-resistance-training-an-effective-intervention-in-adults-with-muscular-dystrophy
#8
D O'Dowd, C Morse, E Bostock, D Smith, C Payton
No abstract text is available yet for this article.
July 2, 2018: Gait & Posture
https://www.readbyqxmd.com/read/30006002/mathematical-analysis-to-prioritise-strategies-for-malaria-elimination
#9
Nakul Chitnis, Allan Schapira, Christian Schindler, Melissa Penny, Thomas Smith
Malaria and some other tropical diseases are currently targeted for elimination and eventually eradication. Since resources are limited, prioritisation of countries or areas for elimination is often necessary. However, this prioritisation is frequently conducted in an ad hoc manner. Lower transmission areas are usually targeted for elimination first, but for some areas this necessitates long and potentially expensive surveillance programs while transmission is eliminated from neighbouring higher transmission areas...
July 10, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/30005773/future-developments-in-neoadjuvant-therapy-for-triple-negative-breast-cancer
#10
REVIEW
Lakisha Moore-Smith, Andres Forero-Torres, Erica Stringer-Reasor
Breast cancer is the 2nd leading cause of cancer-related death in women in the United States. In general, advances in targeted treatment for breast cancer have improved over the last twenty years, except in the triple-negative breast cancer (TNBC) subtype. TNBC is an aggressive breast cancer subtype with limited treatment options as compared to hormone positive breast cancers. Recently, genomic profiling of TNBC shows promise in aiding clinicians to develop personalized targeted agents. Prioritizing novel molecular-based therapies in the neoadjuvant setting may help investigators understand mechanisms of resistance and ultimately improve patient outcomes in TNBC...
August 2018: Surgical Clinics of North America
https://www.readbyqxmd.com/read/30005687/do-emotions-influence-the-motivations-and-preferences-of-keepers-of-stingless-bees
#11
Roberta Monique Amâncio Carvalho, Celso Feitosa Martins, Rômulo Romeu Nóbrega Alves, Ângelo Giuseppe Chaves Alves
BACKGROUND: According to the biophilia hypothesis, an emotional affiliation with nature has been inherited during human biocultural evolution. Research on beekeeping can contribute to the scientific understanding of the influence of emotions in the human-nature relationship, since this activity provides concrete experiences of beneficial interaction between the human being and the environment by stimulating conservation-friendly values among practitioners. In this study, we investigated motivations and preferences driving beekeepers' choices...
July 13, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/30005388/transgenerational-effects-of-chemotherapy-both-male-and-female-children-born-to-women-exposed-to-chemotherapy-have-fewer-children
#12
Biren Patel, Huong Meeks, Yuan Wan, Erica B Johnstone, Martha Glenn, Ken R Smith, James M Hotaling
BACKGROUND: There is little known about the transgenerational effect of chemotherapy. For example, chemotherapy is known to decrease fecundity in women. But if women are able to have offspring after chemotherapy exposure, do these children also have decreased fecundity? METHODS: This study is a retrospective cohort study utilizing the Utah Population Database (UPDB), a comprehensive resource that links birth, medical, death and cancer records for individuals in the state of Utah...
July 10, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/30005144/the-peth-blood-test-in-the-security-environment-what-it-is-why-it-is-important-and-interpretative-guidelines
#13
REVIEW
William Ulwelling, Kim Smith
Testing for phosphatidylethanol (PEth) is a relatively new tool for detecting and grossly quantifying a person's use of alcohol in a variety of security, medical, and legal environments. The basic chemistry of PEth is explained with a particular focus on factors that make it highly suitable as a biomarker for alcohol use in such situations. This article meets the need for a literature review that synthesizes PEth laboratory findings and suggests updated guidelines for interpretation. Several ethanol biomarkers have been used for detection or monitoring alcohol use but have significant limitations...
July 13, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/30005037/development-of-a-modified-cervical-deformity-frailty-index-a-streamlined-clinical-tool-for-preoperative-risk-stratification
#14
Peter G Passias, Cole A Bortz, Frank A Segreto, Samantha R Horn, Renaud Lafage, Virginie Lafage, Justin S Smith, Breton Line, Han Jo Kim, Robert Eastlack, D Kojo Hamilton, Themistocles Protopsaltis, Richard A Hostin, Eric O Klineberg, Douglas C Burton, Robert A Hart, Frank J Schwab, Shay Bess, Christopher I Shaffrey, Christopher P Ames
STUDY DESIGN: Retrospective review OBJECTIVE.: Develop a simplified frailty index for CD patients SUMMARY OF BACKGROUND DATA.: To improve preoperative risk stratification for surgical cervical deformity (CD) patients, a CD frailty index (CD-FI) incorporating 40 health deficits was developed. While novel, the CD-FI is clinically impractical due to the large number of factors needed for its calculation. To increase clinical utility, a simpler, modified CD-FI (mCD-FI) is necessary. METHODS: CD patients (C2-C7 Cobb>10°, CL>10°, cSVA>4 cm, or CBVA>25°) >18yr with preoperative CD-FI component factors...
July 12, 2018: Spine
https://www.readbyqxmd.com/read/30004879/modelling-and-simulation-of-a-lower-extremity-powered-exoskeleton
#15
Brandon N Fournier, Edward D Lemaire, Andrew J J Smith, Marc Doumit
Lower extremity powered exoskeletons (LEPEs) allow people with spinal cord injury (SCI) to stand and walk. However, the majority of LEPEs walk slowly and users can become fatigued from overuse of forearm crutches, suggesting LEPE design can be enhanced. Virtual prototyping is a cost-effective way of improving design; therefore, this research developed and validated two models that simulate walking with the Bionik Laboratories' ARKE exoskeleton attached to a human musculoskeletal model. The first model was driven by kinematic data from 30 able-bodied participants walking at realistic slow walking speeds (0...
July 9, 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/30004725/amplitude-analysis-of-the-decay-b-over-%C3%A2-0-%C3%A2-k_-s-0-%C3%AF-%C3%AF-and-first-observation-of-the-cp-asymmetry-in-b-over-%C3%A2-0-%C3%A2-k-892-%C3%AF
#16
R Aaij, B Adeva, M Adinolfi, Z Ajaltouni, S Akar, J Albrecht, F Alessio, M Alexander, A Alfonso Albero, S Ali, G Alkhazov, P Alvarez Cartelle, A A Alves, S Amato, S Amerio, Y Amhis, L An, L Anderlini, G Andreassi, M Andreotti, J E Andrews, R B Appleby, F Archilli, P d'Argent, J Arnau Romeu, A Artamonov, M Artuso, E Aslanides, M Atzeni, G Auriemma, M Baalouch, I Babuschkin, S Bachmann, J J Back, A Badalov, C Baesso, S Baker, V Balagura, W Baldini, A Baranov, R J Barlow, C Barschel, S Barsuk, W Barter, F Baryshnikov, V Batozskaya, V Battista, A Bay, L Beaucourt, J Beddow, F Bedeschi, I Bediaga, A Beiter, L J Bel, N Beliy, V Bellee, N Belloli, K Belous, I Belyaev, E Ben-Haim, G Bencivenni, S Benson, S Beranek, A Berezhnoy, R Bernet, D Berninghoff, E Bertholet, A Bertolin, C Betancourt, F Betti, M-O Bettler, M van Beuzekom, Ia Bezshyiko, S Bifani, P Billoir, A Birnkraut, A Bizzeti, M Bjørn, T Blake, F Blanc, S Blusk, V Bocci, T Boettcher, A Bondar, N Bondar, I Bordyuzhin, S Borghi, M Borisyak, M Borsato, F Bossu, M Boubdir, T J V Bowcock, E Bowen, C Bozzi, S Braun, T Britton, J Brodzicka, D Brundu, E Buchanan, C Burr, A Bursche, J Buytaert, W Byczynski, S Cadeddu, H Cai, R Calabrese, R Calladine, M Calvi, M Calvo Gomez, A Camboni, P Campana, D H Campora Perez, L Capriotti, A Carbone, G Carboni, R Cardinale, A Cardini, P Carniti, L Carson, K Carvalho Akiba, G Casse, L Cassina, M Cattaneo, G Cavallero, R Cenci, D Chamont, M Charles, Ph Charpentier, G Chatzikonstantinidis, M Chefdeville, S Chen, S F Cheung, S-G Chitic, V Chobanova, M Chrzaszcz, A Chubykin, P Ciambrone, X Cid Vidal, G Ciezarek, P E L Clarke, M Clemencic, H V Cliff, J Closier, J Cogan, E Cogneras, V Cogoni, L Cojocariu, P Collins, T Colombo, A Comerma-Montells, A Contu, A Cook, G Coombs, S Coquereau, G Corti, M Corvo, C M Costa Sobral, B Couturier, G A Cowan, D C Craik, A Crocombe, M Cruz Torres, R Currie, C D'Ambrosio, F Da Cunha Marinho, E Dall'Occo, J Dalseno, A Davis, O De Aguiar Francisco, S De Capua, M De Cian, J M De Miranda, L De Paula, M De Serio, P De Simone, C T Dean, D Decamp, L Del Buono, H-P Dembinski, M Demmer, A Dendek, D Derkach, O Deschamps, F Dettori, B Dey, A Di Canto, P Di Nezza, H Dijkstra, F Dordei, M Dorigo, A Dosil Suárez, L Douglas, A Dovbnya, K Dreimanis, L Dufour, G Dujany, P Durante, R Dzhelyadin, M Dziewiecki, A Dziurda, A Dzyuba, S Easo, M Ebert, U Egede, V Egorychev, S Eidelman, S Eisenhardt, U Eitschberger, R Ekelhof, L Eklund, S Ely, S Esen, H M Evans, T Evans, A Falabella, N Farley, S Farry, D Fazzini, L Federici, D Ferguson, G Fernandez, P Fernandez Declara, A Fernandez Prieto, F Ferrari, F Ferreira Rodrigues, M Ferro-Luzzi, S Filippov, R A Fini, M Fiorini, M Firlej, C Fitzpatrick, T Fiutowski, F Fleuret, K Fohl, M Fontana, F Fontanelli, D C Forshaw, R Forty, V Franco Lima, M Frank, C Frei, J Fu, W Funk, E Furfaro, C Färber, E Gabriel, A Gallas Torreira, D Galli, S Gallorini, S Gambetta, M Gandelman, P Gandini, Y Gao, L M Garcia Martin, J García Pardiñas, J Garra Tico, L Garrido, P J Garsed, D Gascon, C Gaspar, L Gavardi, G Gazzoni, D Gerick, E Gersabeck, M Gersabeck, T Gershon, Ph Ghez, S Gianì, V Gibson, O G Girard, L Giubega, K Gizdov, V V Gligorov, D Golubkov, A Golutvin, A Gomes, I V Gorelov, C Gotti, E Govorkova, J P Grabowski, R Graciani Diaz, L A Granado Cardoso, E Graugés, E Graverini, G Graziani, A Grecu, R Greim, P Griffith, L Grillo, L Gruber, B R Gruberg Cazon, O Grünberg, E Gushchin, Yu Guz, T Gys, C Göbel, T Hadavizadeh, C Hadjivasiliou, G Haefeli, C Haen, S C Haines, B Hamilton, X Han, T H Hancock, S Hansmann-Menzemer, N Harnew, S T Harnew, C Hasse, M Hatch, J He, M Hecker, K Heinicke, A Heister, K Hennessy, P Henrard, L Henry, E van Herwijnen, M Heß, A Hicheur, D Hill, C Hombach, P H Hopchev, W Hu, Z C Huard, W Hulsbergen, T Humair, M Hushchyn, D Hutchcroft, P Ibis, M Idzik, P Ilten, R Jacobsson, J Jalocha, E Jans, A Jawahery, F Jiang, M John, D Johnson, C R Jones, C Joram, B Jost, N Jurik, S Kandybei, M Karacson, J M Kariuki, S Karodia, N Kazeev, M Kecke, F Keizer, M Kelsey, M Kenzie, T Ketel, E Khairullin, B Khanji, C Khurewathanakul, T Kirn, S Klaver, K Klimaszewski, T Klimkovich, S Koliiev, M Kolpin, R Kopecna, P Koppenburg, A Kosmyntseva, S Kotriakhova, M Kozeiha, L Kravchuk, M Kreps, F Kress, P Krokovny, F Kruse, W Krzemien, W Kucewicz, M Kucharczyk, V Kudryavtsev, A K Kuonen, T Kvaratskheliya, D Lacarrere, G Lafferty, A Lai, G Lanfranchi, C Langenbruch, T Latham, C Lazzeroni, R Le Gac, A Leflat, J Lefrançois, R Lefèvre, F Lemaitre, E Lemos Cid, O Leroy, T Lesiak, B Leverington, P-R Li, T Li, Y Li, Z Li, T Likhomanenko, R Lindner, F Lionetto, V Lisovskyi, X Liu, D Loh, A Loi, I Longstaff, J H Lopes, D Lucchesi, M Lucio Martinez, H Luo, A Lupato, E Luppi, O Lupton, A Lusiani, X Lyu, F Machefert, F Maciuc, V Macko, P Mackowiak, S Maddrell-Mander, O Maev, K Maguire, D Maisuzenko, M W Majewski, S Malde, B Malecki, A Malinin, T Maltsev, G Manca, G Mancinelli, D Marangotto, J Maratas, J F Marchand, U Marconi, C Marin Benito, M Marinangeli, P Marino, J Marks, G Martellotti, M Martin, M Martinelli, D Martinez Santos, F Martinez Vidal, L M Massacrier, A Massafferri, R Matev, A Mathad, Z Mathe, C Matteuzzi, A Mauri, E Maurice, B Maurin, A Mazurov, M McCann, A McNab, R McNulty, J V Mead, B Meadows, C Meaux, F Meier, N Meinert, D Melnychuk, M Merk, A Merli, E Michielin, D A Milanes, E Millard, M-N Minard, L Minzoni, D S Mitzel, A Mogini, J Molina Rodriguez, T Mombacher, I A Monroy, S Monteil, M Morandin, M J Morello, O Morgunova, J Moron, A B Morris, R Mountain, F Muheim, M Mulder, D Müller, J Müller, K Müller, V Müller, P Naik, T Nakada, R Nandakumar, A Nandi, I Nasteva, M Needham, N Neri, S Neubert, N Neufeld, M Neuner, T D Nguyen, C Nguyen-Mau, S Nieswand, R Niet, N Nikitin, T Nikodem, A Nogay, D P O'Hanlon, A Oblakowska-Mucha, V Obraztsov, S Ogilvy, R Oldeman, C J G Onderwater, A Ossowska, J M Otalora Goicochea, P Owen, A Oyanguren, P R Pais, A Palano, M Palutan, A Papanestis, M Pappagallo, L L Pappalardo, W Parker, C Parkes, G Passaleva, A Pastore, M Patel, C Patrignani, A Pearce, A Pellegrino, G Penso, M Pepe Altarelli, S Perazzini, P Perret, L Pescatore, K Petridis, A Petrolini, A Petrov, M Petruzzo, E Picatoste Olloqui, B Pietrzyk, M Pikies, D Pinci, A Pistone, A Piucci, V Placinta, S Playfer, M Plo Casasus, F Polci, M Poli Lener, A Poluektov, I Polyakov, E Polycarpo, G J Pomery, S Ponce, A Popov, D Popov, S Poslavskii, C Potterat, E Price, J Prisciandaro, C Prouve, V Pugatch, A Puig Navarro, H Pullen, G Punzi, W Qian, R Quagliani, B Quintana, B Rachwal, J H Rademacker, M Rama, M Ramos Pernas, M S Rangel, I Raniuk, F Ratnikov, G Raven, M Ravonel Salzgeber, M Reboud, F Redi, S Reichert, A C Dos Reis, C Remon Alepuz, V Renaudin, S Ricciardi, S Richards, M Rihl, K Rinnert, V Rives Molina, P Robbe, A Robert, A B Rodrigues, E Rodrigues, J A Rodriguez Lopez, A Rogozhnikov, S Roiser, A Rollings, V Romanovskiy, A Romero Vidal, J W Ronayne, M Rotondo, M S Rudolph, T Ruf, P Ruiz Valls, J Ruiz Vidal, J J Saborido Silva, E Sadykhov, N Sagidova, B Saitta, V Salustino Guimaraes, C Sanchez Mayordomo, B Sanmartin Sedes, R Santacesaria, C Santamarina Rios, M Santimaria, E Santovetti, G Sarpis, A Sarti, C Satriano, A Satta, D M Saunders, D Savrina, S Schael, M Schellenberg, M Schiller, H Schindler, M Schmelling, T Schmelzer, B Schmidt, O Schneider, A Schopper, H F Schreiner, M Schubiger, M-H Schune, R Schwemmer, B Sciascia, A Sciubba, A Semennikov, E S Sepulveda, A Sergi, N Serra, J Serrano, L Sestini, P Seyfert, M Shapkin, I Shapoval, Y Shcheglov, T Shears, L Shekhtman, V Shevchenko, B G Siddi, R Silva Coutinho, L Silva de Oliveira, G Simi, S Simone, M Sirendi, N Skidmore, T Skwarnicki, E Smith, I T Smith, J Smith, M Smith, L Soares Lavra, M D Sokoloff, F J P Soler, B Souza De Paula, B Spaan, P Spradlin, S Sridharan, F Stagni, M Stahl, S Stahl, P Stefko, S Stefkova, O Steinkamp, S Stemmle, O Stenyakin, M Stepanova, H Stevens, S Stone, B Storaci, S Stracka, M E Stramaglia, M Straticiuc, U Straumann, J Sun, L Sun, W Sutcliffe, K Swientek, V Syropoulos, T Szumlak, M Szymanski, S T'Jampens, A Tayduganov, T Tekampe, G Tellarini, F Teubert, E Thomas, J van Tilburg, M J Tilley, V Tisserand, M Tobin, S Tolk, L Tomassetti, D Tonelli, F Toriello, R Tourinho Jadallah Aoude, E Tournefier, M Traill, M T Tran, M Tresch, A Trisovic, A Tsaregorodtsev, P Tsopelas, A Tully, N Tuning, A Ukleja, A Usachov, A Ustyuzhanin, U Uwer, C Vacca, A Vagner, V Vagnoni, A Valassi, S Valat, G Valenti, R Vazquez Gomez, P Vazquez Regueiro, S Vecchi, M van Veghel, J J Velthuis, M Veltri, G Veneziano, A Venkateswaran, T A Verlage, M Vernet, M Vesterinen, J V Viana Barbosa, B Viaud, D Vieira, M Vieites Diaz, H Viemann, X Vilasis-Cardona, M Vitti, V Volkov, A Vollhardt, B Voneki, A Vorobyev, V Vorobyev, C Voß, J A de Vries, C Vázquez Sierra, R Waldi, C Wallace, R Wallace, J Walsh, J Wang, D R Ward, H M Wark, N K Watson, D Websdale, A Weiden, C Weisser, M Whitehead, J Wicht, G Wilkinson, M Wilkinson, M Williams, M P Williams, M Williams, T Williams, F F Wilson, J Wimberley, M Winn, J Wishahi, W Wislicki, M Witek, G Wormser, S A Wotton, K Wraight, K Wyllie, Y Xie, M Xu, Z Xu, Z Yang, Z Yang, Y Yao, H Yin, J Yu, X Yuan, O Yushchenko, K A Zarebski, M Zavertyaev, L Zhang, Y Zhang, A Zhelezov, Y Zheng, X Zhu, V Zhukov, J B Zonneveld, S Zucchelli
The time-integrated untagged Dalitz plot of the three-body hadronic charmless decay B[over ¯]^{0}→K_{S}^{0}π^{+}π^{-} is studied using a pp collision data sample recorded with the LHCb detector, corresponding to an integrated luminosity of 3.0  fb^{-1}. The decay amplitude is described with an isobar model. Relative contributions of the isobar amplitudes to the B[over ¯]^{0}→K_{S}^{0}π^{+}π^{-} decay branching fraction and CP asymmetries of the flavor-specific amplitudes are measured. The CP asymmetry between the conjugate B[over ¯]^{0}→K^{*}(892)^{-}π^{+} and B^{0}→K^{*}(892)^{+}π^{-} decay rates is determined to be -0...
June 29, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30004713/correction-to-2-2-2-to-3-2-1-bicycle-skeletal-rearrangement-approach-to-the-gibberellin-family-of-natural-products
#17
Brandon R Smith, Jon T Njardarson
No abstract text is available yet for this article.
July 13, 2018: Organic Letters
https://www.readbyqxmd.com/read/30004689/characterisation-of-the-interaction-between-arginine-methyltransferase-hmt1-and-its-substrate-npl3-use-of-multiple-crosslinkers-mass-spectrometry-approaches-and-software-platforms
#18
Daniela-Lee Smith, Michael Goetze, Gene Hart-Smith, Marc R Wilkins, Tara Bartolec
This study investigated the enzyme-substrate interaction between the Saccharomyces cerevisiae arginine methyltransferase Hmt1p and nucleolar protein Npl3p, using chemical crosslinking-mass spectrometry (XL-MS). We show that XL-MS can capture transient inter-protein interactions that occur during the process of methylation, involving a disordered region in Npl3p with tandem SRGG repeats, and confirm that Hmt1p and Npl3p exist as homo-multimers. Additionally, the study investigated the interdependencies between variables of an XL-MS experiment, that lead to the identification of identical or different crosslinked peptides...
July 13, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/30004674/molecular-determinants-of-substrate-specificity-in-human-insulin-degrading-enzyme
#19
Lazaros Stefanidis, Nicholas D Fusco, Samantha E Cooper, Jillian Smith-Carpenter, Benjamin J Alper
Insulin-degrading enzyme (IDE) is a 110 kDa chambered zinc metalloendopeptidase that degrades insulin, amyloid beta, and other intermediate-sized aggregation prone peptides that adopt β-structures. Structural studies of IDE in complex with multiple physiological substrates have suggested a role for hydrophobic and aromatic residues of the IDE active site in substrate binding and catalysis. Here, we examine functional requirements for conserved hydrophobic and aromatic IDE active site residues that are positioned within 4...
July 13, 2018: Biochemistry
https://www.readbyqxmd.com/read/30004542/real-time-in-situ-dynamic-sub-surface-imaging-of-multi-component-electrodeposited-films-using-event-mode-neutron-reflectivity
#20
A Robert Hillman, Robert Barker, Robert M Dalgliesh, Virginia C Ferreira, Emma J R Palin, Rachel M Sapstead, Emma L Smith, Nina-Juliane Steinke, Karl S Ryder, Andrew D Ballantyne
Exquisite control of the electrodeposition of metal films and coatings is critical to a number of high technology and manufacturing industries, delivering functionality as diverse as anti-corrosion and anti-wear coatings, electronic device interconnects and energy storage. The frequent involvement of more than one metal motivates the capability to control, maintain and monitor spatial disposition of the component metals, whether as multilayers, alloys or composites. Here we investigate the deposition, evolution and dissolution of single and two-component metal layers involving Ag, Cu, and Sn on Au substrates immersed in the deep eutectic solvent (DES) Ethaline...
July 13, 2018: Faraday Discussions
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