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https://www.readbyqxmd.com/read/28724273/effects-of-inhaled-salbutamol-on-sport-specific-fitness-of-non-asthmatic-football-players
#1
Farzin Halabchi, Mahdi Abarashi, Mohammad Ali Mansournia, Tohid Seifbarghi
In this article, we investigated the effectiveness of inhaled salbutamol withtherapeutic dose on the sport-specific performance of non-asthmatic young football players. In a double-blinded, randomised placebo controlled trial with 2-treatment, 2-period crossover design, twenty participants who were non-asthmatic junior professional football players were randomly allocated to two groups. Fifteen minutes before sport-specific fitness testing, each group randomly received 2 inhalations (200 micrograms) of salbutamol or placebo, respectively...
May 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28724134/association-of-implantable-cardioverter-defibrillators-with-survival-in-patients-with-and-without-improved-ejection-fraction-secondary-analysis-of-the-sudden-cardiac-death-in-heart-failure-trial
#2
Selcuk Adabag, Kristen K Patton, Alfred E Buxton, Thomas S Rector, Kristine E Ensrud, Kairav Vakil, Wayne C Levy, Jeanne E Poole
Importance: Improvement in left ventricular ejection fraction (EF) to >35% occurs in many patients with reduced EF at baseline. To our knowledge, whether implantable cardioverter defibrillator (ICD) therapy improves survival for these patients is unknown. Objective: To examine the efficacy of ICD therapy in reducing risk of all-cause mortality and sudden cardiac death among patients with an EF ≤35% at baseline, with or without an improvement in EF to >35% during follow-up...
July 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28723914/safety-and-pharmacodynamics-of-dalazatide-a-kv1-3-channel-inhibitor-in-the-treatment-of-plaque-psoriasis-a-randomized-phase-1b-trial
#3
Eric J Tarcha, Chelsea M Olsen, Peter Probst, David Peckham, Ernesto J Muñoz-Elías, James G Kruger, Shawn P Iadonato
BACKGROUND: Dalazatide is a specific inhibitor of the Kv1.3 potassium channel. The expression and function of Kv1.3 channels are required for the function of chronically activated memory T cells, which have been shown to be key mediators of autoimmune diseases, including psoriasis. OBJECTIVE: The primary objective was to evaluate the safety of repeat doses of dalazatide in adult patients with mild-to-moderate plaque psoriasis. Secondary objectives were to evaluate clinical proof of concept and the effects of dalazatide on mediators of inflammation in the blood and on chronically activated memory T cell populations...
2017: PloS One
https://www.readbyqxmd.com/read/28723843/no-superior-adaptations-to-carbohydrate-periodization-in-elite-endurance-athletes
#4
Kasper Degn Gejl, Line Thams, Mette Hansen, Torben Rokkedal-Lausch, Peter Plomgaard, Lars Nybo, Filip J Larsen, Daniele A Cardinale, Kurt Jensen, Hans-Christer Holmberg, Kristian Vissing, Niels Ørtenblad
PURPOSE: The present study investigated the effects of periodic CHO restriction on endurance performance and metabolic markers in elite endurance athletes. METHODS: Twenty-six male elite endurance athletes (VO2max: 65.0 ml O2[BULLET OPERATOR]kg[BULLET OPERATOR]min) completed 4 weeks of regular endurance training, while matched and randomized into two groups training with (Low) or without (High) carbohydrate (CHO) manipulation three days a week. The CHO manipulation days consisted of a 1-hr high intensity bike session in the morning, recovery for 7 hrs while consuming isocaloric diets containing either high CHO (414±2...
July 19, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28723821/can-a-balance-wristband-influence-postural-control
#5
Sven Eichhorn, Sonja Foerster, Benedikt Friemert, Christian Willy, Hans-Joachim Riesner, Hans-Georg Palm
Top sports performances cannot be achieved without a high level of postural control. Balance wristbands purport to improve the mental and physical balance of the wearer. It is still unclear, however, whether these wristbands can indeed enhance postural control. Our purpose was to ascertain by means of computerized dynamic posturography whether balance wristbands can improve postural stability.In this randomized controlled single-blind clinical study, posturography was used to assess postural control in 179 healthy subjects with or without a balance wristband...
July 14, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28723815/effect-of-energy-drink-consumption-on-power-and-velocity-of-selected-sport-performance-activities
#6
Bert H Jacobson, Garrett M Hester, Ty B Palmer, Kathryn Williams, Zachary K Pope, John H Sellers, Eric C Conchola, Conrad Woolsey, Carlos Estrada
Energy drinks comprise a multibillion dollar market focused on younger, active and competitive individuals. Marketing includes claims of improved alertness and performance. The purpose of this study was to assess power (W) and velocity (m·s) of a simulated, isolated forehand stroke (FHS) and a counter movement vertical jump (CVJ) before and after ingestion of a commercially available energy shot (ES) or a placebo (PL). Healthy college-aged male and female (N=36) volunteers were randomly placed in the ES or PL...
July 17, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28723796/moist-exposed-burn-ointment-for-treating-pressure-ulcers-a-multicenter-randomized-controlled-trial
#7
Wei Li, Yubo Ma, Qi Yang, Yu Pan, Qinggang Meng
BACKGROUND: Pressure ulcers often seriously affect the quality of life of patients. Moist Exposed Burn Ointment (MEBO) has been developed to treat patients with pressure ulcers. The present study aimed to evaluate the efficacy and safety of MEBO in the treatment of pressure ulcers in Chinese patients. METHODS: Seventy-two patients with pressure ulcers were randomly assigned to 2 groups who received a placebo or MEBO for 2 months. The primary outcomes included the wound surface area (WSA) and pressure ulcer scale for healing (PUSH) tool...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723597/short-term-results-of-intra-tympanic-gentamicin-and-dexamethasone-on-hearing-and-tinnitus-in-meniere-s-disease-a-case-control-study
#8
Irfan Ul Shamas
INTRODUCTION: The role of this study was to evaluate the effectiveness of intra tympanic administration of Gentamicin(40 mgs/ml) and Dexamethasone 0.5 ml(4 mgs/ml) on hearing and tinnitus of patients who had recurrent acute attacks of vertigo, tinnitus and hearing loss. STUDY DESIGN: 60 consecutive patients of Meniere's disease were randomly divided into 3 groups of twenty patients each. Group A included 20 patients who received intra tympanic gentamicin, Group B included 20 patients who received intra tympanic dexamethasone and Group C included 20 patients who received intra tympanic normal saline 0...
June 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28723522/efficacy-and-safety-of-hexanic-lipidosterolic-extract-of-serenoa-repens-permixon-in-the-treatment-of-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#9
REVIEW
Giacomo Novara, Gianluca Giannarini, Antonio Alcaraz, José-M Cózar-Olmo, Aurelien Descazeaud, Francesco Montorsi, Vincenzo Ficarra
CONTEXT: A recent Cochrane Collaboration meta-analysis of randomized controlled trials (RCTs) evaluating the efficacy of different extracts of Serenoa repens in relieving lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) concluded that these extracts were no more effective than placebo. However, among all Serenoa repens extracts, Permixon (Pierre Fabre Medicament, Paris, France) has the highest activity and the most accurate standards of drug preparation and extraction...
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723227/extended-release-guanfacine-does-not-show-a-large-effect-on-tic-severity-in-children-with-chronic-tic-disorders
#10
Tanya K Murphy, Thomas V Fernandez, Barbara J Coffey, Omar Rahman, Allison Gavaletz, Camille E Hanks, Caitlin S Tillberg, Laura Ibanez Gomez, Denis G Sukhodolsky, Lily Katsovich, Lawrence Scahill
OBJECTIVE: To evaluate the tolerability, safety, and preliminary efficacy of extended-release guanfacine in children with chronic tic disorders, including Tourette's disorder (collectively referred to as CTD). METHODS: This was a multisite, 8-week, randomized, double-blind, placebo-controlled trial. The primary outcome measure was the Yale Global Tic Severity Scale (YGTSS) total score. Key secondary outcomes included the Improvement item of Clinical Global Impressions-Improvement (CGI-I) scale and the Tic Symptom Self-report (TSSR)...
July 19, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28722815/influence-of-morphine-and-naloxone-on-pain-modulation-in-rheumatoid-arthritis-chronic-fatigue-syndrome-fibromyalgia-and-controls-a-double-blind-randomized-placebo-controlled-cross-over-study
#11
Linda Hermans, Jo Nijs, Patrick Calders, Luc De Clerck, Greta Moorkens, Guy Hans, Sofie Grosemans, Tine Roman De Mettelinge, Joanna Tuynman, Mira Meeus
BACKGROUND: Impaired pain inhibitory and enhanced pain facilitatory mechanisms are repeatedly reported in patients with central sensitization pain. However, the exact effects of frequently prescribed opioids on central pain modulation are still unknown. METHODS: A randomized, double-blind, placebo-controlled cross-over trial was carried out. Ten CFS/FM patients, 11 RA patients and 20 controls were randomly allocated to the experimental (10 mg morphine or 0.2 mg/ml Naloxone) and placebo (2 ml Aqua) group...
July 19, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28722422/first-time-view-on-human-metabolome-changes-after-a-single-intake-of-3-4-methylenedioxymethamphetamine-mdma-in-healthy-placebo-controlled-subjects
#12
Martina I Boxler, Matthias E Liechti, Yasmin Schmid, Thomas Kraemer, Andrea E Steuer
3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy') is widely consumed recreationally. Currently little is known about its effects on the human metabolome. Mapping biochemical changes after drug exposure can complement traditional approaches by revealing potential biomarkers of organ toxicity or discovering new metabolomic features in a time- and dose-dependent manner. We aimed to analyze for the first time plasma samples from a randomized, double-blind, placebo-controlled crossover study in healthy adults to explore changes in endogenous plasma metabolites following a single intake of MDMA...
July 19, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28722271/beyond-glycemic-control-a-cross-over-double-blind-24-week-intervention-with-liraglutide-in-type-1-diabetes
#13
M-C Dubé, M D'Amours, S J Weisnagel
AIMS: To investigate the effects of 24 weeks of treatment with liraglutide added to basal/bolus insulin on anthropometric and metabolic parameters in overweight participants with type 1 diabetes. METHODS: In a double-blind cross-over fashion, 15 participants were randomly assigned (1:1) to receive placebo (saline solution) or liraglutide for 24 weeks including a one-month titration period from 0.6 mg to 1.2 mg to 1.8 mg, in addition to their insulin. The treatment was followed by a 1 month wash-out period...
July 18, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28721545/is-topiramate-effective-for-migraine-prevention-in-patients-less-than-18%C3%A2-years-of-age-a-meta-analysis-of-randomized-controlled-trials
#14
REVIEW
Kai Le, Dafan Yu, Jiamin Wang, Abdoulaye Idriss Ali, Yijing Guo
BACKGROUND: Mainly based on evidence of success in adults, various medications are commonly used to prevent pediatric migraines. Topiramate has been approved for migraine prevention in children as young as 12 years of age. In this meta-analysis, we aimed to assess the currently published data pertaining to the efficacy of topiramate for migraine prevention in patients less than 18 years of age. METHODS: We searched PubMed/Medline, Embase and the Cochrane Library (from inception to April 2017) for randomized controlled trials (RCTs) published in English...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28721535/tricyclic-and-tetracyclic-antidepressants-for-the-prevention-of-frequent-episodic-or-chronic-tension-type-headache-in-adults-a-systematic-review-and-meta-analysis
#15
Jeffrey L Jackson, Josephine M Mancuso, Sarah Nickoloff, Rebecca Bernstein, Cynthia Kay
BACKGROUND: Tension-type headaches are a common source of pain and suffering. Our purpose was to assess the efficacy of tricyclic (TCA) and tetracyclic antidepressants in the prophylactic treatment of tension-type headache. METHODS: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, the ISI Web of Science, and clinical trial registries through 11 March 2017 for randomized controlled studies of TCA or tetracyclic antidepressants in the prevention of tension-type headache in adults...
July 18, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28721467/a-review-of-the-safety-efficacy-and-mechanisms-of-delivery-of-nasal-oxytocin-in-children-therapeutic-potential-for-autism-and-prader-willi-syndrome-and-recommendations-for-future-research
#16
Marilena M DeMayo, Yun Ju C Song, Ian B Hickie, Adam J Guastella
In this article, we conduct a comprehensive review of existing evidence for the safety and therapeutic potential of intranasal oxytocin in pediatric populations. Unique considerations for dosing and delivery of oxytocin to the nasal passageway in pediatric populations and methods to promote adherence are reviewed. Intranasal oxytocin has been administered to 261 children in three open-label studies and eight randomized controlled trials. To date, the only published results in pediatric populations have focused on autism spectrum disorder (ASD) and Prader-Willi syndrome (PWS)...
July 18, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28721341/effects-of-eplerenone-on-resistance-to-antihypertensive-medication-in-patients-with-primary-or-secondary-hyperaldosteronism
#17
J David Spence, Chrysi Bogiatzi, Mariya Kuk, George K Dresser, Daniel G Hackam
BACKGROUND AND OBJECTIVES: Resistant hypertension is an important problem; nearly half of diagnosed hypertensives are not controlled to target blood pressure levels, and approximately 90% of strokes occur among patients with resistant hypertension. Primary aldosteronism accounts for approximately 20% of resistant hypertension, but the role of secondary hyperaldosteronism in resistant hypertension is seldom considered. We assessed the effects of eplerenone in patients with hypertension and either primary or secondary hyperaldosteronism...
June 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28721137/beneficial-effects-of-n-3-polyunsaturated-fatty-acids-on-adiponectin-levels-and-adipor-gene-expression-in-patients-with-type-2-diabetes-mellitus-a-randomized-placebo-controlled-double-blind-clinical-trial
#18
Maryam Mazaherioun, Ahmad Saedisomeolia, Mohammad Hassan Javanbakht, Fariba Koohdani, Mohammad Reza Eshraghian, Mahmoud Djalali
INTRODUCTION: There is evidence that n-3 polyunsaturated fatty acids (n-3 PUFAs) exert beneficial effects to improve type 2 diabetes mellitus (T2DM), but its complications remain poorly understood. Hypoadiponectinemia is one of the important mechanisms responsible for T2DM which necessitates developing novel therapeutic strategies. We aimed to determine the effect of n-3 PUFA supplementation on circulating adiponectin and mRNA expression of adiponectin receptors (AdipoR1, AdipoR2) and Sirt-1 in T2DM patients...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28720838/the-efficacy-and-safety-of-sugammadex-for-reversing-postoperative-residual-neuromuscular-blockade-in-pediatric-patients-a-systematic-review
#19
Guangyu Liu, Rui Wang, Yanhong Yan, Long Fan, Jixiu Xue, Tianlong Wang
The aim of this study is to evaluate the efficacy and safety of sugammadex for reversing neuromuscular blockade in pediatric patients. MEDLINE and other three Databases were searched. Randomized clinical trials were included if they compared sugammadex with neostigmine or placebo in pediatric patients undergoing surgery involving the use of rocuronium or vecuronium. The primary outcome was the time interval from administration of reversal agents to train-of-four ratio (TOFr, T4/T1) > 0.9. Incidences of any drug-related adverse events were secondary outcomes...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720615/assessment-of-the-effectiveness-and-safety-of-ethosuximide-in-the-treatment-of-abdominal-pain-related-to-irritable-bowel-syndrome-ibset-protocol-of-a-randomised-parallel-controlled-double-blind-and-multicentre-trial
#20
Nicolas Kerckhove, Julien Scanzi, Bruno Pereira, Denis Ardid, Michel Dapoigny
INTRODUCTION: Irritable bowel syndrome (IBS) is characterised by the association of abdominal chronic pain with bowel habit disorders in the absence of identifiable organic disease. This is the first reason for consultation in gastroenterology, with an estimated prevalence of 10%-15% in industrialised countries. Although this is a benign gastrointestinal disease, its chronicity profoundly impacts the patient's quality of life and causes considerable health spending. Actual medical treatments are poorly efficient on IBS-related abdominal pain, making it a major public health concern...
July 18, 2017: BMJ Open
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