keyword
MENU ▼
Read by QxMD icon Read
search

Randomized placebo

keyword
https://www.readbyqxmd.com/read/29166666/evaluating-the-efficacy-of-an-active-compression-brace-on-orthostatic-cardiovascular-responses
#1
Hadi Moein, Ramandeep Jhalli, Andrew P Blaber, Victoria E Claydon, Carlo Menon
Orthostatic intolerance, one of the principle causes of syncope, can occur secondary to concomitant venous pooling and enhanced capillary filtration. We aimed to evaluate a prototype portable calf active compression brace (ACB) designed to improve orthostatic haemodynamic control. Fourteen healthy volunteers participated in a randomized, placebo controlled, cross-over, double-blind study. Testing consisted of head-upright tilting and walking on a treadmill conducted on two consecutive days with a pair of ACBs wrapped around both calves...
2017: PloS One
https://www.readbyqxmd.com/read/29166376/predictors-of-death-in-infants-with-probable-serious-bacterial-infection
#2
Prashant Singh, Ananya Arora, Tor A Strand, Halvor Sommerfelt, Rakesh Lodha, Sushil Kumar Kabra, Satinder Aneja, Uma Chandra Mouli Natchu, Jagdish Chandra, Bimbadhar Rath, Vinod Kumar Sharma, Mohini Kumari, Savita Saini, Shinjini Bhatnagar, Nitya Wadhwa
INTRODUCTION: Bacterial infections account for a significant proportion of neonatal and infant mortality globally. We aimed to identify predictors of death in infants with probable serious bacterial infection (PSBI) defined as signs/symptoms of possible serious bacterial infection along with baseline C-reactive protein (CRP) ≥12 mg/lMETHODS:We did a secondary analysis using the data collected from 700 infants with PSBI who participated in a randomized controlled trial in India in which zinc or placebo was given in addition to standard antibiotics...
November 22, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29166256/infection-free-clinical-response-among-patients-with-hidradenitis-suppurativa-who-were-treated-with-adalimumab-results-from-two-phase-3-studies
#3
Evangelos J Giamarellos-Bourboulis, Jeffrey Sobell, Caitriona Ryan, Pierre J Wolkenstein, Ziqian Geng, Gerit D Mulder
OBJECTIVE: The objective of this study is to assess the rates of infection-free achievement of hidradenitis suppurativa clinical response (HiSCR) using integrated data from 2 phase 3, placebo-controlled trials, PIONEER I and II. MATERIALS AND METHODS: Analyses from the first 12 weeks of both studies were examined. Patients were randomized to receive adalimumab (ADA) or placebo, and they then were assessed in the clinic at weeks 0, 2, 4, 8, and 12. All reports of an adverse or serious adverse event and infection were classified as treatment-emergent adverse events (TEAEs)...
November 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29165355/acute-effects-of-nitrate-rich-beetroot-juice-on-blood-pressure-hemostasis-and-vascular-inflammation-markers-in-healthy-older-adults-a-randomized-placebo-controlled-crossover-study
#4
Kyle Raubenheimer, Danica Hickey, Michael Leveritt, Robert Fassett, Joaquin Ortiz de Zevallos Munoz, Jason D Allen, David Briskey, Tony J Parker, Graham Kerr, Jonathan M Peake, Natalie M Pecheniuk, Oliver Neubauer
Aging is associated with a vasoconstrictive, pro-coagulant, and pro-inflammatory profile of arteries and a decline in the bioavailability of the endothelium-derived molecule nitric oxide. Dietary nitrate elicits vasodilatory, anti-coagulant and anti-inflammatory effects in younger individuals, but little is known about whether these benefits are evident in older adults. We investigated the effects of 140 mL of nitrate-rich (HI-NI; containing 12.9 mmol nitrate) versus nitrate-depleted beetroot juice (LO-NI; containing ≤0...
November 22, 2017: Nutrients
https://www.readbyqxmd.com/read/29165093/a-randomized-double-blind-placebo-controlled-crossover-study-to-assess-the-safety-and-beneficial-effects-of-cassia-tora-supplementation-in-healthy-adults
#5
Himavanth Reddy Kambalachenu, Thandlam Muneeswa Reddy, Sirpurkar Dattatreya Rao, Kambalachenu Dorababu, Kanala Kodanda Reddy, Kvs Sarma
OBJECTIVE: The current clinical trial was aimed at evaluating the safety and beneficial effect of Cassia tora (C.tora) supplementation in healthy adults. DESIGN: A randomized, double blind, placebo controlled study with a crossover design was done on 60 healthy normal weight adults (age range: 20-55 yrs). The study consisted of 2 treatment phases of 24 weeks each with a washout period of 4 weeks between the phases. 30 subjects randomly allocated to the 'Placebo first' group and 30 to 'C...
November 19, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29165021/two-years-of-tamoxifen-or-no-adjuvant-systemic-therapy-for-patients-with-high-risk-breast-cancer-long-term-follow-up-of-the-copenhagen-breast-cancer-trial
#6
Maj-Britt Jensen, Jens Fabricius Krarup, Torben Palshof, Henning T Mouridsen, Bent Ejlertsen
BACKGROUND: The Copenhagen Breast Cancer Trial (CBCT) randomly assigned patients with early breast cancer to two years of tamoxifen or placebo and we evaluated the effect over the following four decades. PATIENT AND METHODS: Between 1975 and 1978, 327 patients with primary breast cancer were randomly assigned to two years of daily placebo or tamoxifen. Survival statistics was collected from the Danish Civil Registration System. RESULTS: The five-year invasive breast cancer recurrence (BCR) rate was 43...
November 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29164954/a-systematic-review-of-ustekinumab-in-the-treatment-of-atopic-dermatitis
#7
Yunlei Pan, Lina Xu, Jianjun Qiao, Hong Fang
Ustekinumab is a human monoclonal IgG1 antibody targeting the p40 subunit shared by IL-12 and IL-23. We reviewed the published literature by searching from PubMed, EMBASE, Web of Science and ClinicalTrial.gov to evaluate the efficacy and safety of ustekinumab in the treatment of AD. Ten studies including eight cases and two RCT, comprising 107 patients, were included in the systematic review. Analysis all studies, a total of 58 patients (54.2%) gained an effective treatment with little adverse events. Ustekinumab is a well-tolerated and safe treatment with no significant difference in effect from placebo in patients with AD...
November 22, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29164923/impact-of-traditional-versus-flavored-tongue-depressors-on-pediatric-oropharynx-exam
#8
Brian Murray, Marina Gore, Nicole R Leonard, Nadia M Pearson, Jeremiah J Johnson, Michael D April
We compared patient-reported discomfort associated with oropharynx examination using traditional (unflavored) versus flavored tongue depressors among pediatric patients presenting to the emergency department in a single-blinded, placebo-controlled randomized trial using a convenience sample ages 3 to 12 years. Our primary outcome was patient discomfort. Secondary outcomes included provider perceptions of patient discomfort, provider-reported examination ease, and caregiver perceptions of patient discomfort...
November 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/29164723/double-blind-placebo-controlled-trial-of-the-effect-of-omalizumab-on-basophils-in-chronic-urticaria-patients
#9
Lukas Jörg, Tatjana Pecaric-Petkovic, Stephan Reichenbach, Michael Coslovsky, Odile Stalder, Werner Pichler, Oliver Hausmann
BACKGROUND: Omalizumab has been shown to be effective in treating chronic spontaneous urticaria (CSU). The reduction of FcεRI receptor density on the surface of basophils and mast cells is thought to play a major role in its effectiveness. We conducted a double-blind, randomized, placebo-controlled trial to investigate the mode of action of omalizumab in patients with antihistamine-resistant CSU. METHODS: Thirty patients were randomized in a 2:1 ratio to receive either 300 mg omalizumab or placebo...
November 22, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29164421/ribociclib-plus-letrozole-versus-letrozole-alone-in-patients-with-de-novo-hr-her2-advanced-breast-cancer-in-the-randomized-monaleesa-2-trial
#10
Joyce O'Shaughnessy, Katarina Petrakova, Gabe S Sonke, Pierfranco Conte, Carlos L Arteaga, David A Cameron, Lowell L Hart, Cristian Villanueva, Erik Jakobsen, Joseph T Beck, Deborah Lindquist, Farida Souami, Shoubhik Mondal, Caroline Germa, Gabriel N Hortobagyi
PURPOSE: Determine the efficacy and safety of first-line ribociclib plus letrozole in patients with de novo advanced breast cancer. METHODS: Postmenopausal women with HR+ , HER2- advanced breast cancer and no prior systemic therapy for advanced disease were enrolled in the Phase III MONALEESA-2 trial (NCT01958021). Patients were randomized to ribociclib (600 mg/day; 3 weeks-on/1 week-off) plus letrozole (2.5 mg/day; continuous) or placebo plus letrozole until disease progression, unacceptable toxicity, death, or treatment discontinuation...
November 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29164312/efficacy-and-safety-of-rotigotine-in-elderly-patients-with-parkinson-s-disease-in-comparison-with-the-non-elderly-a-post-hoc-analysis-of-randomized-double-blind-placebo-controlled-trials
#11
Masahiro Nomoto, Hirotaka Iwaki, Hiroyuki Kondo, Masaya Sakurai
Rotigotine-a non-ergot dopamine agonist-has two advantages; it can stimulate all dopamine receptors (D1-D5) like innate dopamine, and its transdermal administration provides continuous dopaminergic stimulation. The age of the patient impacts the effect and adverse events of anti-parkinsonian treatment. We conducted a post hoc analysis on three randomized, double-blind, placebo-controlled trials performed in Japan to clarify the difference of anti-parkinsonian treatment in elderly and non-elderly patients. Data from two combination therapy trials (with levodopa) in advanced stage Parkinson's disease patients and one monotherapy trial in early stage patients were pooled and grouped by age (non-elderly aged < 70, elderly aged 70 +)...
November 21, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29164254/effect-of-oral-insulin-on-prevention-of-diabetes-in-relatives-of-patients-with-type-1-diabetes-a-randomized-clinical-trial
#12
Jeffrey P Krischer, Desmond A Schatz, Brian Bundy, Jay S Skyler, Carla J Greenbaum
Importance: Type 1 diabetes requires major lifestyle changes and carries increased morbidity and mortality. Prevention or delay of diabetes would have major clinical effect. Objective: To determine whether oral insulin delays onset of type 1 diabetes in autoantibody-positive relatives of patients with type 1 diabetes. Design, Setting, and Participants: Between March 2, 2007, and December 21, 2015, relatives with at least 2 autoantibodies, including insulin autoantibodies and normal glucose tolerance, were enrolled in Canada, the United States, Australia, New Zealand, the United Kingdom, Italy, Sweden, Finland, and Germany...
November 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29164116/potential-of-metformin-to-improve-cardiac-risk-in-postpartum-women-with-gestational-diabetes
#13
Oscar A Viteri, Mary Alice Sallman, Pauline M Berens, Pamela D Berens, Farah H Amro, Maria S Hutchinson, Susan M Ramin, Sean C Blackwell, Jerrie S Refuerzo, Judith A Smith
Objective: Pregnancy is associated with an increase in total cholesterol, high density lipoproteins (HDL), and low-density lipoproteins (LDL). Postpartum, HDL and LDL decrease over the first 12 weeks postpartum. Oxidized LDL (ox-LDL) is a marker of oxidative stress-related inflammation, which is associated with obesity and also with development of cardiovascular disease. Cardiovascular protection and weight loss are benefits from metformin, especially in women with diabetes. The objective of this study was to compare changes in lipid profiles and biomarkers for obesity during the initial 6 weeks postpartum between women with gestational diabetes mellitus (GDM) treated with metformin versus placebo...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29164021/efficacy-safety-and-timing-of-anticoagulant-thromboprophylaxis-for-the-prevention-of-venous-thromboembolism-in-patients-with-acute-spinal-cord-injury-a-systematic-review
#14
REVIEW
Paul M Arnold, James S Harrop, Geno Merli, Lindsay G Tetreault, Brian K Kwon, Steve Casha, Katherine Palmieri, Jefferson R Wilson, Michael G Fehlings, Haley K Holmer, Daniel C Norvell
Study Design: Systematic review. Objectives: The objective of this study was to answer 5 key questions: What is the comparative effectiveness and safety of (1a) anticoagulant thromboprophylaxis compared to no prophylaxis, placebo, or another anticoagulant strategy for preventing deep vein thrombosis (DVT) and pulmonary embolism (PE) after acute spinal cord injury (SCI)? (1b) Mechanical prophylaxis strategies alone or in combination with other strategies for preventing DVT and PE after acute SCI? (1c) Prophylactic inferior vena cava filter insertion alone or in combination with other strategies for preventing DVT and PE after acute SCI? (2) What is the optimal timing to initiate and/or discontinue anticoagulant, mechanical, and/or prophylactic inferior vena cava filter following acute SCI? (3) What is the cost-effectiveness of these treatment options? Methods: A systematic literature search was conducted to identify studies published through February 28, 2015...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29163833/a-systematic-review-and-meta-analysis-of-effectiveness-and-safety-of-therapy-for-overactive-bladder-using-botulinum-toxin-a-at-different-dosages
#15
Hui-Yun Gu, Ju-Kun Song, Wen-Jun Zhang, Jin Xie, Qi-Sheng Yao, Wen-Jing Zeng, Chao Zhang, Yu-Ming Niu
Purpose: To assess the effectiveness and safety of botulinum toxin A (BTX-A) at different dosages for overactive bladder (OAB). Materials and Methods: The MEDLINE, EMBASE, and Cochrane Controlled Trials Register databases were searched through November 3, 2016 to identify relevant randomized controlled trials (RCTs). Results: Eleven studies were identified in this meta-analysis. Compared with placebo, the urinary incontinence (UI) episodes per week as the primary outcomes, urodynamic parameters including maximum cystometric capacity (MCC), and maximum detrusor pressure (MDP) for neurogenic detrusor overactivity (NDO) at 6 weeks, and for idiopathic detrusor overactivity (IDO) at 36 weeks were evaluated...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163162/a-randomized-double-blinded-clinical-trial-on-effects-of-a-vitis-vinifera-extract-on-cognitive-function-in-healthy-older-adults
#16
Gioacchino Calapai, Francesco Bonina, Andrea Bonina, Luisa Rizza, Carmen Mannucci, Vincenzo Arcoraci, Germana Laganà, Angela Alibrandi, Concetta Pollicino, Santi Inferrera, Umberto Alecci
Introduction: Gradual population aging is creating a new set of needs in the general population. Memory capacity decreases with age, and memory deficits are considered an early symptom of Alzheimer's Disease (AD), one of the most prevalent cognitive disorders in older people. Numerous studies have shown that grape polyphenolic compounds (GPs) are able to attenuate cognitive impairment and reduce brain lesions in experimental AD animal models. These GP effects are associated with improvement in brain antioxidant status and prevention of free radical-induced neuronal damage...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29163147/chronic-psychological-stress-was-not-ameliorated-by-omega-3-eicosapentaenoic-acid-epa
#17
Joanne Bradbury, Stephen P Myers, Barbara Meyer, Lyndon Brooks, Jonathan Peake, Andrew J Sinclair, Con Stough
Background: Chronic psychological stress and mental health disorders are endemic in Western culture where population dietary insufficiencies of omega-3 fatty acids (n-3FA) from seafood have been observed. Objective: This study was designed to test for a causal relationship between one of the most active components of fish oil, eicosapentaenoic acid (EPA), and chronic psychological stress. Method: A randomized double-blind, placebo-controlled clinical trial with parallel-assignment to two groups was designed (Trial Id: ACTRN12610000404022)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29162032/the-metabolic-side-effects-of-12-antipsychotic-drugs-used-for-the-treatment-of-schizophrenia-on-glucose-a-network-meta-analysis
#18
Yangyu Zhang, Yingyu Liu, Yingying Su, Yueyue You, Yue Ma, Guang Yang, Yan Song, Xinyu Liu, Mohan Wang, Lili Zhang, Changgui Kou
BACKGROUND: Antipsychotics have serious metabolic side effects on blood glucose. However, the comparative influence of these drugs on blood glucose levels has not been comprehensively evaluated. We conducted a network meta-analysis to create a hierarchy of the side effects of 12 antipsychotic drugs on changes in blood glucose levels. METHODS: A systematic search of the PubMed, EMBASE and Cochrane databases (last search June 2016) was conducted to identify studies that reported randomized controlled trials (RCTs) comparing changes in blood glucose levels between patients receiving one of 12 antipsychotic drugs or a placebo for the treatment of schizophrenia or related disorders...
November 21, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29161773/silodosin-for-the-treatment-of-lower-urinary-tract-symptoms-in-men-with-benign-prostatic-hyperplasia
#19
REVIEW
Jae Hung Jung, Jiye Kim, Roderick MacDonald, Balaji Reddy, Myung Ha Kim, Philipp Dahm
BACKGROUND: A variety of alpha-blockers are used for treating lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). Silodosin is a novel, more selective alpha-blocker, which is specific to the lower urinary tract and may have fewer side effects than other alpha-blockers. OBJECTIVES: To assess the effects of silodosin for the treatment of LUTS in men with BPH. SEARCH METHODS: We performed a comprehensive search using multiple databases (Cochrane Library, MEDLINE, EMBASE, Scopus, Google Scholar, and Web of Science), trials registries, other sources of grey literature, and conference proceedings with no restrictions on the language of publication or publication status up until 13 June 2017...
November 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29161458/proton-pump-inhibitors-for-functional-dyspepsia
#20
REVIEW
Maria Ines Pinto-Sanchez, Yuhong Yuan, Ahmed Hassan, Premysl Bercik, Paul Moayyedi
BACKGROUND: Functional dyspepsia (FD or non-ulcer dyspepsia) is defined as continuous or frequently recurring epigastric pain or discomfort for which no organic cause can be found. Acid suppressive therapy, including proton pump inhibitors (PPIs), has been proposed as a therapeutic option in FD, but its efficacy remains controversial. While PPIs are generally considered safe and well tolerated, they have been associated with adverse events, especially in the long term. For this reason, decisions on whether to initiate or continue PPI therapy should be made based on an appropriate clinical indication...
November 21, 2017: Cochrane Database of Systematic Reviews
keyword
keyword
39999
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"