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https://www.readbyqxmd.com/read/29342272/daily-decision-making-about-food-during-pregnancy-a-new-zealand-study
#1
Susan Pullon, Angela Ballantyne, Lindsay Macdonald, Christine Barthow, Kristin Wickens, Julian Crane
Pregnancy has always been a life-changing event for women and their families, but societal concern about pregnancy and motherhood has become intense in the digital age. The role of health promotion agencies and others supplying health-related resources about lifestyle behaviours is both important and in need of scrutiny. Ever increasing advice for pregnant women, their families and health professionals, abounds. This study of decision making during pregnancy investigated how women made everyday decisions during pregnancy about food and drink, as well as dietary supplements and medications, alcohol and recreational drugs...
January 12, 2018: Health Promotion International
https://www.readbyqxmd.com/read/29342248/clinical-considerations-of-the-role-of-palbociclib-in-the-management-of-advanced-breast-cancer-patients-with-and-without-visceral-metastases
#2
N C Turner, R S Finn, M Martin, S-A Im, A DeMichele, J Ettl, V Diéras, S Moulder, O Lipatov, M Colleoni, M Cristofanilli, D R Lu, A Mori, C Giorgetti, S Iyer, C Huang Bartlett, K A Gelmon
Background: This report assesses the efficacy and safety of palbociclib plus endocrine therapy (ET) in women with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer (ABC) with or without visceral metastases. Patients and methods: Pre- and postmenopausal women with disease progression following prior ET (PALOMA-3; N=521) and postmenopausal women untreated for ABC (PALOMA-2; N=666) were randomized 2:1 to ET (fulvestrant or letrozole, respectively) plus palbociclib or placebo...
January 11, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29342163/doxylamine-pyridoxine-for-nausea-and-vomiting-of-pregnancy-randomized-placebo-controlled-trial-prespecified-analyses-and-reanalysis
#3
Navindra Persaud, Christopher Meaney, Khaled El-Emam, Rahim Moineddin, Kevin Thorpe
BACKGROUND: Doxylamine-pyridoxine is recommended as a first line treatment for nausea and vomiting during pregnancy and it is commonly prescribed. We re-analysed the findings of a previously reported superiority trial of doxylamine-pyridoxine for the treatment of nausea and vomiting during pregnancy using the clinical study report obtained from Health Canada. METHODS AND FINDINGS: We re-analysed individual level data for a parallel arm randomized controlled trial that was conducted in six outpatient obstetrical practices in the United States...
2018: PloS One
https://www.readbyqxmd.com/read/29341503/tadalafil-5-mg-once-daily-improves-lower-urinary-tract-symptoms-and-erectile-dysfunction-a-systematic-review-and-meta-analysis
#4
Yilin Wang, Yiping Bao, Jie Liu, Lijun Duan, Yuanshan Cui
OBJECTIVES: We carried out a systematic review and meta-analysis to assess tadalafil 5 mg once-daily for the treatment of lower urinary tract symptoms (LUTS) and erectile dysfunction (ED). METHODS: A literature review was performed to identify all published randomized double-blind, placebo-controlled trials of tadalafil 5 mg once-daily for the treatment of LUTS and ED. The search included the following databases: MEDLINE, EMBASE, and the Cochrane Controlled Trials Register...
January 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29341071/anticholinergic-medication-for-antipsychotic-induced-tardive-dyskinesia
#5
REVIEW
Hanna Bergman, Karla Soares-Weiser
BACKGROUND: Antipsychotic (neuroleptic) medication is used extensively to treat people with serious mental illnesses. However, it is associated with a wide range of adverse effects, including movement disorders. Because of this, many people treated with antipsychotic medication also receive anticholinergic drugs in order to reduce some of the associated movement side-effects. However, there is also a suggestion from animal experiments that the chronic administration of anticholinergics could cause tardive dyskinesia...
January 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29341067/vitamin-e-for-antipsychotic-induced-tardive-dyskinesia
#6
REVIEW
Karla Soares-Weiser, Nicola Maayan, Hanna Bergman
BACKGROUND: Antipsychotic (neuroleptic) medication is used extensively to treat people with chronic mental illnesses. Its use, however, is associated with adverse effects, including movement disorders such as tardive dyskinesia (TD) - a problem often seen as repetitive involuntary movements around the mouth and face. Vitamin E has been proposed as a treatment to prevent or decrease TD. OBJECTIVES: The primary objective was to determine the clinical effects of vitamin E in people with schizophrenia or other chronic mental illness who had developed antipsychotic-induced TD...
January 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29340809/randomized-controlled-study-of-intraincisional-infiltration-versus-intraperitoneal-instillation-of-standardized-dose-of-ropivacaine-0-2-in-post-laparoscopic-cholecystectomy-pain-do-we-really-need-high-doses-of-local-anesthetics-time-to-rethink
#7
Singh Mathuria Kaushal-Deep, Afzal Anees, Shehtaj Khan, Mohammad Amanullah Khan, Mehershree Lodhi
BACKGROUND: Earlier studies done to compare the efficacy of use of local anesthetics at intraperitoneal location versus intraincisional use had utilized equal amount of drugs at the two locations, usually 10-20 ml. Using this large amount of drug in the small space of intraincisional location as compared to similar amount of drug in large intraperitoneal space created an inadvertent bias in favor of patients receiving the drug intraincisionally so these patients naturally experienced less pain...
January 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29340321/randomized-clinical-trial-design-to-assess-abatacept-in-resistant-nephrotic-syndrome
#8
Howard Trachtman, Debbie S Gipson, Michael Somers, Cathie Spino, Sharon Adler, Lawrence Holzman, Jeffrey B Kopp, John Sedor, Sandra Overfield, Ayanbola Elegbe, Michael Maldonado, Anna Greka
Introduction: Treatment-resistant nephrotic syndrome is a rare form of glomerular disease that occurs in children and adults. No Food and Drug Administration-approved treatments consistently achieve remission of proteinuria and preservation of kidney function. CD80 (B7-1) can be expressed on injured podocytes, and administration of abatacept (modified CTLA4-Ig based on a natural ligand to CD80) has been associated with sustained normalization of urinary protein excretion and maintenance of glomerular filtration rate in experimental and clinical settings...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29340316/npt-iib-inhibition-does-not-improve-hyperphosphatemia-in-ckd
#9
Tobias E Larsson, Chisato Kameoka, Ikumi Nakajo, Yuta Taniuchi, Satoshi Yoshida, Tadao Akizawa, Ronald A Smulders
Introduction: Serum phosphate levels are insufficiently controlled in many patients with end-stage renal disease (ESRD), and novel therapeutic strategies are needed. Blocking intestinal phosphate absorption mediated by sodium-dependent phosphate co-transporter type 2b (NPT-IIb) holds promise; thus, we evaluated the efficacy, safety, tolerability, and pharmacokinetics of the novel and specific small molecule NPT-IIb inhibitor ASP3325 for the first time in humans. Methods: We conducted a randomized, double-blind, placebo-controlled, phase 1a single (n = 88) and multiple (n = 36) ascending dose study in healthy subjects, and a randomized, open-label, uncontrolled, phase 1b study in hyperphosphatemic ESRD patients on hemodialysis (single oral dose, n = 5; multiple oral doses, n = 17)...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29339630/comparison-of-the-efficacy-of-different-drugs-on-non-motor-symptoms-of-parkinson-s-disease-a-network-meta-analysis
#10
Bao-Dong Li, Jing-Jun Cui, Jia Song, Ce Qi, Pei-Feng Ma, Ya-Rong Wang, Jing Bai
BACKGROUND/AIMS: A network meta-analysis is used to compare the efficacy of ropinirole, rasagiline, rotigotine, entacapone, apomorphine, pramipexole, sumanirole, bromocriptine, piribedil and levodopa, with placebo as a control, for non-motor symptoms in Parkinson's disease (PD). METHODS: PubMed, Embase and the Cochrane Library were searched from their establishment dates up to January 2017 for randomized controlled trials (RCTs) investigating the efficacy of the above ten drugs on the non-motor symptoms of PD...
January 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29339527/diminished-androgen-and-estrogen-receptors-and-aromatase-levels-in-hypogonadal-diabetic-men-reversal-with-testosterone
#11
Husam Ghanim, Sandeep Dhindsa, Sanaa Abuaysheh, Manav Batra, Nitesh Kuhadiya, Antoine Makdissi, Ajay Chaudhuri, Paresh Dandona
AIMS: One third of males with type 2 diabetes have hypogonadism, characterized by low total and free testosterone concentrations. We hypothesized that this condition is associated with a compensatory increase in the expression of androgen receptors (AR) and that testosterone replacement reverses these changes. We also measured estrogen receptor and aromatase expression. MATERIALS AND METHODS: This is a randomized double-blind placebo controlled trial. 32 hypogonadal and 32 eugonadal men with type 2 diabetes were recruited...
January 16, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29339109/bitter-gourd-reduces-elevated-fasting-plasma-glucose-levels-in-an-intervention-study-among-prediabetics-in-tanzania
#12
Michael B Krawinkel, Christine Ludwig, Mark E Swai, Ray-Yu Yang, Kwok Pan Chun, Sandra D Habicht
ETHNOPHARMACOLOGICAL RELEVANCE: Impaired glucose tolerance and diabetes mellitus have become major health issues even in non-industrialized countries. As access to clinical management is often poor, dietary interventions and alternative medicines are required. For bitter gourd, Momordica charantia L., antidiabetic properties have been claimed. AIM OF THE STUDY: The main objective of the intervention study was to assess antidiabetic effects of daily bitter gourd consumption of 2...
January 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29338762/predictors-of-remission-with-etanercept-methotrexate-induction-therapy-and-loss-of-remission-with-etanercept-maintenance-reduction-or-withdrawal-in-moderately-active-rheumatoid-arthritis-results-of-the-preserve-trial
#13
Josef S Smolen, Annette Szumski, Andrew S Koenig, Thomas V Jones, Lisa Marshall
BACKGROUND: The aim was to analyze characteristics that predict remission induction and subsequent loss of remission in patients with moderately active rheumatoid arthritis (RA) who received full-dose combination etanercept plus methotrexate induction therapy followed by reduced-dose etanercept or etanercept withdrawal. METHODS: Patients with Disease Activity Score based on 28-joint count (DAS28) >3.2 and ≤5.1 received open-label etanercept 50 mg once weekly (QW) plus methotrexate for 36 weeks...
January 16, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29338621/assessing-the-acute-effects-of-cdp-choline-on-sensory-gating-in-schizophrenia-a-pilot-study
#14
Robert Aidelbaum, Alain Labelle, Ashley Baddeley, Verner Knott
Deficient sensory gating (SG) in schizophrenia is associated with functional outcome and offers a therapeutic target as it is linked to the altered function/expression of the α7 nicotinic acetylcholine receptors (nAChRs). This study analyzed the effects of citicoline (CDP-choline), a supplement with α7 nAChRs agonist properties, on SG in a sample of schizophrenia (SZ) patients. Using a randomized, placebo-controlled, double-blind design the dose-dependent (500 mg, 1000 mg, 2000 mg) and baseline-dependent (deficient versus normal suppressors) effects of CDP-choline on SG were examined using the P50 event-related potential (ERP) index of SG...
January 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29338576/effect-of-clinical-response-to-active-drugs-and-placebo-on-antipsychotics-and-mood-stabilizers-relative-efficacy-for-bipolar-depression-and-mania-a-meta-regression-analysis
#15
Francesco Bartoli, Massimo Clerici, Carmen Di Brita, Ilaria Riboldi, Cristina Crocamo, Giuseppe Carrà
BACKGROUND: Randomised placebo-controlled trials investigating treatments for bipolar disorder have been hampered by wide variations of active drugs and placebo clinical response rates. It is important to estimate whether the active drug or placebo response has a greater influence in determining the relative efficacy of drugs for psychosis (antipsychotics) and relapse prevention (mood stabilisers) for bipolar depression and mania. METHODS: We identified 53 randomised, placebo-controlled trials assessing antipsychotic or mood stabiliser monotherapy ('active drugs') for bipolar depression or mania...
January 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29338462/rethinking-revascularization-in-patients-with-stable-angina
#16
Ralf E Harskamp, Duk-Woo Park
Traditional and current perception for benefit of percutaneous coronary intervention (PCI) is that patients with stable angina will obtain symptom relief as well as improved exercise capacity after percutaneous revascularization. This common clinical perception is put to test in the ORBITA trial, the first blinded, randomized placebo-controlled clinical study ever conducted. The findings of this study will send shockwaves throughout the cardiology community.
January 17, 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29337906/specific-collagen-peptides-improve-bone-mineral-density-and-bone-markers-in-postmenopausal-women-a-randomized-controlled-study
#17
Daniel König, Steffen Oesser, Stephan Scharla, Denise Zdzieblik, Albert Gollhofer
Introduction: Investigations in rodents as well as in vitro experiments have suggested an anabolic influence of specific collagen peptides (SCP) on bone formation and bone mineral density (BMD). The goal of the study was to investigate the effect of 12-month daily oral administration of 5 g SCP vs. placebo (CG: control group) on BMD in postmenopausal women with primary, age-related reduction in BMD. Methods: 131 women were enrolled in this randomized, placebo-controlled double-blinded investigation. The primary endpoint was the change in BMD of the femoral neck and the spine after 12 months...
January 16, 2018: Nutrients
https://www.readbyqxmd.com/read/29337835/promethazine-and-oral-midazolam-preanesthetic-children-medication
#18
Sedigheh Nadri, Hormoz Mahmoudvand, Nadereh Taee, Khatereh Anbari, Siavash Beiranvand
AIMS: Several kinds of drugs have been investigated in preschool children as a preanesthetic sedation after various routes of administration for surgeries. This study aims to compare the efficacy of promethazine and oral midazolam for premedication in children aged 3 to 9 years who were scheduled for surgeries. METHODS: This is a double-blind randomized controlled study conducted on 93 patients between the age of 3 and 9 years at Loresten University of Medical Sciences Teaching Hospital, Khoramabad, Iran...
January 15, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29337730/effects-of-electrical-transcutaneous-vagus-nerve-stimulation-on-the-perceived-intensity-of-repetitive-painful-heat-stimuli-a-blinded-placebo-and-sham-controlled-randomized-crossover-investigation
#19
Henriette Janner, Catharina Klausenitz, Nancy Gürtler, Klaus Hahnenkamp, Taras I Usichenko
BACKGROUND: Transcutaneous vagus nerve stimulation (TVNS) is a promising treatment for acute and chronic pain. However, experimental studies yielded controversial results. We examined if TVNS reduces the perceived intensity of repetitive painful heat stimulation and temporal summation of pain (TSP) in healthy volunteers in comparison with placebo and sham stimulation, as well as no intervention. METHODS: In 4 sessions, 90 heat pulse stimuli at individual pain tolerance temperature were applied to the ventral forearm of 49 healthy volunteers (25 women) using a Contact Heat Evoked Potential Stimulator thermode (Medoc, Ramat Yishai, Israel)...
January 15, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29337405/effects-of-transcutaneous-electrical-nerve-stimulation-on-pain-intensity-during-application-of-carboxytherapy-in-patients-with-cellulite-a-randomized-placebo-controlled-trial
#20
Adria Y Sadala, Aline F P Machado, Richard E Liebano
BACKGROUND: Carboxytherapy may generate local pain that is considered the main limiting factor in clinical practice. Transcutaneous electric nerve stimulation (TENS) is widely used in the control of acute pain; however, the effect of TENS on pain relief during carboxytherapy has not been studied to date. AIMS: To assess the effect of TENS on pain intensity during carboxytherapy in patients with cellulite in the gluteal region. PATIENTS/METHODS: This randomized clinical trial was conducted with 84 patients, 18-44 years of age, who had moderate cellulite in the gluteal region, according to Cellulite Severity Scale, but never received carboxytherapy...
January 16, 2018: Journal of Cosmetic Dermatology
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