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https://www.readbyqxmd.com/read/29760374/overview-of-cerebral-edema-during-correction-of-hyperglycemic-crises
#1
Daniel Varela, Natalie Held, Stuart Linas
BACKGROUND Hyperglycemic crises can cause severe neurologic impairment. One of the most dreaded consequences of hyperglycemic crises is cerebral edema, a rare complication seen during the treatment of hyperglycemic crises resulting from overly-aggressive fluid resuscitation and rapid correction of hyperglycemia and hyperosmolarity. CASE REPORT We present a case of profound hyperglycemic crisis with blood glucose greater than 2000 mg/dL, complicated by the development of new neurologic deficits after rapid correction of hyperglycemia...
May 15, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29655834/metformin-use-associates-with-longer-progression-free-survival-of-patients-with-diabetes-and-pancreatic-neuroendocrine-tumors-receiving-everolimus-and-or-somatostatin-analogues
#2
Sara Pusceddu, Claudio Vernieri, Massimo Di Maio, Riccardo Marconcini, Francesca Spada, Sara Massironi, Toni Ibrahim, Maria Pia Brizzi, Davide Campana, Antongiulio Faggiano, Dario Giuffrida, Maria Rinzivillo, Sara Cingarlini, Francesca Aroldi, Lorenzo Antonuzzo, Rossana Berardi, Laura Catena, Chiara De Divitiis, Paola Ermacora, Vittorio Perfetti, Annalisa Fontana, Paola Razzore, Carlo Carnaghi, Maria Vittoria Davì, Carolina Cauchi, Marilina Duro, Sergio Ricci, Nicola Fazio, Federica Cavalcoli, Alberto Bongiovanni, Anna La Salvia, Nicole Brighi, Annamaria Colao, Ivana Puliafito, Francesco Panzuto, Silvia Ortolani, Alberto Zaniboni, Francesco Di Costanzo, Mariangela Torniai, Emilio Bajetta, Salvatore Tafuto, Silvio Ken Garattini, Daniela Femia, Natalie Prinzi, Laura Concas, Giuseppe Lo Russo, Massimo Milione, Luca Giacomelli, Roberto Buzzoni, Gianfranco Delle Fave, Vincenzo Mazzaferro, Filippo de Braud
BACKGROUND & AIMS: Metformin seems to have anti-cancer effects. However, it is not clear whether use of glycemia and metformin affect outcomes of patients with advanced pancreatic neuroendocrine tumors (pNETs). We investigated the association between glycemia and progression-free survival (PFS) of patients with NETs treated with everolimus and/or somatostatin analogues, as well as the association between metformin use and PFS time. METHODS: We performed a retrospective analysis of 445 patients with advanced pNET treated at 24 medical centers in Italy, from 1999 through 2015...
April 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29600506/prediabetes-directly-deteriorates-into-diabetic-ketoacidosis-and-hyperosmolar-hyperglycemic-syndrome-triggered-by-acute-pancreatitis-a-case-report-illustrating-a-chicken-and-egg-paradigm-in-ketosis-prone-diabetes
#3
Runbo Song, Shanjin Cao
INTRODUCTION: Diabetic crises occur most often in patients with type 1 diabetes and occasionally in type 2 diabetes, especially under stressful conditions. However, a diabetic crisis occurring directly from prediabetes is an unusual phenomenon. CASE REPORT: A 45-year-old woman presented with postprandial left upper quadrant abdominal pain, nausea, and vomiting. She had a past medical history of prediabetes with impaired fasting glucose and HbA1c 6.4%. On admission, routine laboratory tests showed high anion gap metabolic acidosis (pH 6...
March 29, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29544233/-diabetic-ketoacidosis-and-hyperosmolar-hyperglycemic-state
#4
Christina Schumann, Michael Faust
BACKGROUND:  Diabetic ketoacidosis and the hyperosmolar hyperglycemic state are the most serious diabetic emergencies. Before the discovery of insulin in 1921 by Banting and Best the diagnosis of type 1 diabetes was fatal ending in diabetic ketoacidosis equivalent to a torturous death. Today, mortality from diabetic ketoacidosis is low at approximately 2 %. But each death from these two acute metabolic complications of diabetes is potentially avoidable by improved patient and healthcare professional education...
March 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29409767/association-of-hyperglycemic-crisis-with-an-increased-risk-of-end-stage-renal-disease-a-nationwide-population-based-cohort-study
#5
Yuan Kao, I-Jung Feng, Chien-Chin Hsu, Jhi-Joung Wang, Hung-Jung Lin, Chien-Cheng Huang
BACKGROUND: A hyperglycemic crisis episode (HCE) is associated with poor management of diabetes, which is a risk factor for end-stage renal disease (ESRD); however, the association between an HCE and ESRD has not been clarified. We conducted a nationwide population-based cohort study with the purpose of delineating this issue. METHODS: We identified 9208 diabetic patients with an HCE and an identical number of diabetic patients with matched age, sex, and index date without an HCE between 2000 and 2002...
April 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29165723/the-impact-of-hyperosmolarity-on-long-term-outcome-in-patients-presenting-with-severe-hyperglycemic-crisis-a-population-based-study
#6
Ivan Kruljac, Miroslav Ćaćić, Petra Ćaćić, Lora Stanka Kirigin Biloš, Davor Kust, Božidar Perić, Maja Filipović-Grčić, Gorana Mirošević, Vedran Ostojić, Mario Štefanović, Milan Vrkljan
Aims We compared characteristics of patients with hyperglycemic hyperosmolar state (HHS) and patients with severe hyperglycemia without the signs of hyperosmolarity and ketoacidosis; analyzed long-term all-cause mortality and potential prognostic factors. Methods The studied population included 261 749 adults. HHS was diagnosed in patients with plasma glucose >33.0 mmol/L, ketonuria <1+, and serum osmolarity >320 mmol/L. Patients with plasma glucose >33.0 mmol/L, ketonuria <1+ and serum osmolarity <320 mmol/L were considered as controls (nHHS)...
November 17, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29067261/active-cocaine-use-does-not-increase-the-likelihood-of-hyperglycemic-crisis
#7
Katherine L Modzelewski, Denis V Rybin, Janice M Weinberg, Sara M Alexanian, Marie E McDonnell, Devin W Steenkamp
OBJECTIVE: Hyperglycemic crisis encompasses a group of diabetes emergencies characterized by insulin deficiency with high morbidity and mortality. Cocaine use is increasingly prevalent in the United States and may be associated with increased risk of diabetic ketoacidosis. The objective was to determine if active cocaine use at hospital admission could be considered a risk factor for development of hyperglycemic crisis. METHODS: A retrospective case-control analysis was performed on 950 inpatients with hyperglycemia at an urban academic hospital...
September 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/28640151/a-case-report-of-hyperosmolar-hyperglycemic-state-in-a-7-year-old-child-an-unusual-presentation-of-first-appearance-of-type-1-diabetes-mellitus
#8
Young Min Cho, Byung Sung Park, Min Jae Kang
RATIONALE: A hyperosmolar hyperglycemic state (HHS) is a rare presentation of a hyperglycemic crisis in children with diabetes mellitus. As this condition can be fatal and has high morbidity, early recognition and proper management are necessary for a better outcome. Here, we report a rare case of HHS as the first presentation of type 1 diabetes mellitus (T1DM) in a 7-year-old girl. PATIENT CONCERNS: The patient was admitted due to polyuria and weight loss in the past few days...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28570329/endocrine-emergencies-with-neurologic-manifestations
#9
Makoto Ishii
PURPOSE OF REVIEW: This article provides an overview of endocrine emergencies with potentially devastating neurologic manifestations that may be fatal if left untreated. Pituitary apoplexy, adrenal crisis, myxedema coma, thyroid storm, acute hypercalcemia and hypocalcemia, hyperglycemic emergencies (diabetic ketoacidosis and hyperglycemic hyperosmolar state), and acute hypoglycemia are discussed, with an emphasis on identifying the signs and symptoms as well as diagnosing and managing these clinical entities...
June 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28402540/the-hepatic-protection-effects-of-hepassocin-in-hyperglycemic-crisis
#10
Horng-Yih Ou, Hung-Tsung Wu, Ching-Han Lin, Ye-Fong Du, Che-Yuan Hu, Hao-Chang Hung, Pansee Wu, Hung-Yuan Li, Shu-Huei Wang, Chih-Jen Chang
Context: High glucose generates reactive oxygen species (ROS) and contributes to glucotoxicity in hepatocytes, and hyperglycemia causes structural and functional damage to the liver. However, only a mild hepatic dysfunction was observed in subjects with hyperglycemic crisis, implying a factor exists to exert a hepatic protective effect. Hepassocin is a hepatokine that modulates the proliferation and metabolism of hepatocytes and also exerts protective activity in liver injury. However, its role in hyperglycemic crisis-induced hepatic dysfunction remains unknown...
July 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27732094/open-access-to-diabetes-center-from-the-emergency-department-reduces-hospitalizations-in-the-susequent-year
#11
Nadine E Palermo, Katherine L Modzelewski, Alan P Farwell, Jennifer Fosbroke, Kalpana N Shankar, Sara M Alexanian, William E Baker, Donald C Simonson, Marie E McDonnell
OBJECTIVE: Patients who present to the emergency department (ED) for diabetes without hyperglycemic crisis are at risk of unnecessary hospitalizations and poor outcomes. To address this, the ED Diabetes Rapid-referral Program (EDRP) was designed to provide ED staff with direct booking into the diabetes center. The objective of this study was to determine the effects of the EDRP on hospitalization rate, ED utilization rate, glycemic control, and expenditures. METHODS: We conducted a single-center analysis of the EDRP cohort (n = 420) and compared 1-year outcomes to historic controls (n = 791)...
October 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27592119/diabetic-ketosis-during-hyperglycemic-crisis-is-associated-with-decreased-all-cause-mortality-in-patients-with-type-2-diabetes-mellitus
#12
Ivan Kruljac, Miroslav Ćaćić, Petra Ćaćić, Vedran Ostojić, Mario Štefanović, Aljoša Šikić, Milan Vrkljan
Patients with type 2 diabetes mellitus have impaired ketogenesis due to high serum insulin and low growth hormone levels. Evidence exists that ketone bodies might improve kidney and cardiac function. In theory, improved ketogenesis in diabetics may have positive effects. We aimed to assess the impact of diabetic ketosis on all-cause mortality in patients with type 2 diabetes mellitus presenting with hyperglycemic crisis. We analyzed 486 patients with diabetic ketosis and 486 age and sex-matched patients with non-ketotic hyperglycemia presenting to the emergency department...
January 2017: Endocrine
https://www.readbyqxmd.com/read/27311001/effect-of-glycemic-control-on-the-risk-of-pancreatic-cancer-a-nationwide-cohort-study
#13
MULTICENTER STUDY
Kian-Ching Er, Chen-Yang Hsu, Yi-Kung Lee, Ming-Yuan Huang, Yung-Cheng Su
Although the relationship between diabetes and pancreatic cancer has been studied, the effects of glycemic control on pancreatic cancer have never been evaluated. This study investigates the relationship between glycemic control and pancreatic cancer.Data from 1 million National Health Insurance beneficiaries were screened. The study cohort consisted of 46,973 diabetic patients and 652,142 nondiabetic subjects. Of the patients with diabetes, 1114 who had been admitted for hyperglycemic crisis episodes were defined as having poorly controlled diabetes...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27295016/open-access-to-diabetes-center-from-the-emergency-department-reduces-hospitalizations-in-the-subsequent-year
#14
Nadine E Palermo, Katherine L Modzelewski, Alan P Farwell, Jennifer Fosbroke, Kalpana N Shankar, Sara M Alexanian, William E Baker, Donald C Simonson, Marie E McDonnell
OBJECTIVE: Patients who present to the Emergency Department (ED) for diabetes without hyperglycemic crisis are at risk of unnecessary hospitalizations and poor outcomes. To address this, the Emergency Department Diabetes Rapid-referral Program (EDRP) was designed to provide ED staff with direct booking into the diabetes center. The objective of this study was to determine the effect of the EDRP on hospitalization rate, ED utilization rate, glycemic control and expenditures. METHODS: We conducted a single-center analysis of the EDRP cohort (N=420) and compared one year outcomes to historical controls (N=791)...
June 13, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/26968185/expressive-aphasia-as-the-manifestation-of-hyperglycemic-crisis-in-type-2-diabetes
#15
Ji Hyun Lee, Ye An Kim, Joon Ho Moon, Se Hee Min, Young Shin Song, Sung Hee Choi
No abstract text is available yet for this article.
November 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/26862997/a-transient-metabolic-recovery-from-early-life-glucose-intolerance-in-cystic-fibrosis-ferrets-occurs-during-pancreatic-remodeling
#16
Yaling Yi, Xingshen Sun, Katherine Gibson-Corley, Weiliang Xie, Bo Liang, Nan He, Scott R Tyler, Aliye Uc, Louis H Philipson, Kai Wang, Manami Hara, Katie Larson Ode, Andrew W Norris, John F Engelhardt
Cystic fibrosis (CF)-related diabetes in humans is intimately related to exocrine pancreatic insufficiency, yet little is known about how these 2 disease processes simultaneously evolve in CF. In this context, we examined CF ferrets during the evolution of exocrine pancreatic disease. At 1 month of age, CF ferrets experienced a glycemic crisis with spontaneous diabetic-level hyperglycemia. This occurred during a spike in pancreatic inflammation that was preceded by pancreatic fibrosis and loss of β-cell mass...
May 2016: Endocrinology
https://www.readbyqxmd.com/read/26765434/bidirectional-relationship-between-diabetes-and-acute-pancreatitis-a-population-based-cohort-study-in-taiwan
#17
COMPARATIVE STUDY
Yi-Kung Lee, Ming-Yuan Huang, Chen-Yang Hsu, Yung-Cheng Su
The proposed bidirectional relationship between acute pancreatitis (AP) and diabetes has never been examined with the same source of data. Furthermore, the effects of disease severity on this relationship have not been fully evaluated. The present study employed the findings from a single database to measure the strength of the association between AP and diabetes.Findings from 1 million National Health Insurance beneficiaries were utilized. Two cohort studies with this database were selected to evaluate the linkage between diabetes and AP...
January 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26733088/pyruvate-dehydrogenase-activity-is-decreased-in-emergency-department-patients-with-diabetic-ketoacidosis
#18
Lars W Andersen, Katherine M Berg, Sophia Montissol, Christopher Sulmonte, Julia Balkema, Michael N Cocchi, Richard E Wolfe, Ashok Balasubramanyam, Xiaowen Liu, Michael W Donnino
OBJECTIVES: The pyruvate dehydrogenase complex (PDH) is an essential enzyme in aerobic metabolism. Ketones are known to inhibit PDH activity, but the extent of this inhibition is unknown in patients with diabetic ketoacidosis (DKA). METHODS: We enrolled adult patients presenting to the emergency department in hyperglycemic crisis. Patients were classified as DKA or hyperglycemia without ketoacidosis based on laboratory criteria. Healthy controls were also enrolled...
June 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/26466492/-perioperative-blood-glucose-control-in-patients-with-diabetic-mellitus
#19
Moritoki Egi
Current criteria used for the diagnosis of diabetic mellitus are (1) HbA(1c) level > 6.5% (National Glycohemoglobin Standardization Program certified methods), (2) fasting glucose concentration > 126 mg x dl(-1) (7.0 mmol x l(-1)), (3) 2-h plasma glucose concentration > 200 mg x dl(-1) (11.1 mmol x l(-1)) during an oral glucose tolerance test, or (4) classic symptoms of hyperglycemia or hyperglycemic crisis with a random plasma glucose concentration > 200 mg x dl(-1) (11.1 mmol x l(-1)). It is reported that 15-20% of perioperative patients were with the presence of diabetic mellitus...
September 2015: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/26319830/-antioxidant-dysfunctionality-of-high-density-lipoproteins-hdl-in-decompensated-diabetic-patients
#20
Fernanda Awad, Susana Contreras-Duarte, Patricia Molina, Verónica Quiñones, Valentina Serrano, Eduardo Abbott, Alberto Maiz, Dolores Busso, Attilio Rigotti
INTRODUCTION: high density lipoproteins (HDL) have important cardiovascular protective effects mediated by their role in reverse cholesterol transport as well as other functional activities, including significant anti-inflammatory and antioxidant properties. It has been shown that HDL anti-inflammatory and antioxidant functions are defective in metabolically stable diabetic patients; however they have not been evaluated during a hyperglycemic crisis. AIM: to determine the antioxidant activity of HDL during a severe diabetic decompensation and to analyze whether this function is restored after resolution of the acute event...
September 1, 2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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