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https://www.readbyqxmd.com/read/27732094/open-access-to-diabetes-center-from-the-emergency-department-reduces-hospitalizations-in-the-susequent-year
#1
Nadine E Palermo, Katherine L Modzelewski, Alan P Farwell, Jennifer Fosbroke, Kalpana N Shankar, Sara M Alexanian, William E Baker, Donald C Simonson, Marie E McDonnell
OBJECTIVE: Patients who present to the emergency department (ED) for diabetes without hyperglycemic crisis are at risk of unnecessary hospitalizations and poor outcomes. To address this, the ED Diabetes Rapid-referral Program (EDRP) was designed to provide ED staff with direct booking into the diabetes center. The objective of this study was to determine the effects of the EDRP on hospitalization rate, ED utilization rate, glycemic control, and expenditures. METHODS: We conducted a single-center analysis of the EDRP cohort (n = 420) and compared 1-year outcomes to historic controls (n = 791)...
October 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27592119/diabetic-ketosis-during-hyperglycemic-crisis-is-associated-with-decreased-all-cause-mortality-in-patients-with-type-2-diabetes-mellitus
#2
Ivan Kruljac, Miroslav Ćaćić, Petra Ćaćić, Vedran Ostojić, Mario Štefanović, Aljoša Šikić, Milan Vrkljan
Patients with type 2 diabetes mellitus have impaired ketogenesis due to high serum insulin and low growth hormone levels. Evidence exists that ketone bodies might improve kidney and cardiac function. In theory, improved ketogenesis in diabetics may have positive effects. We aimed to assess the impact of diabetic ketosis on all-cause mortality in patients with type 2 diabetes mellitus presenting with hyperglycemic crisis. We analyzed 486 patients with diabetic ketosis and 486 age and sex-matched patients with non-ketotic hyperglycemia presenting to the emergency department...
September 3, 2016: Endocrine
https://www.readbyqxmd.com/read/27311001/effect-of-glycemic-control-on-the-risk-of-pancreatic-cancer-a-nationwide-cohort-study
#3
Kian-Ching Er, Chen-Yang Hsu, Yi-Kung Lee, Ming-Yuan Huang, Yung-Cheng Su
Although the relationship between diabetes and pancreatic cancer has been studied, the effects of glycemic control on pancreatic cancer have never been evaluated. This study investigates the relationship between glycemic control and pancreatic cancer.Data from 1 million National Health Insurance beneficiaries were screened. The study cohort consisted of 46,973 diabetic patients and 652,142 nondiabetic subjects. Of the patients with diabetes, 1114 who had been admitted for hyperglycemic crisis episodes were defined as having poorly controlled diabetes...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27295016/open-access-to-diabetes-center-from-the-emergency-department-reduces-hospitalizations-in-the-subsequent-year
#4
Nadine E Palermo, Katherine L Modzelewski, Alan P Farwell, Jennifer Fosbroke, Kalpana N Shankar, Sara M Alexanian, William E Baker, Donald C Simonson, Marie E McDonnell
OBJECTIVE: Patients who present to the Emergency Department (ED) for diabetes without hyperglycemic crisis are at risk of unnecessary hospitalizations and poor outcomes. To address this, the Emergency Department Diabetes Rapid-referral Program (EDRP) was designed to provide ED staff with direct booking into the diabetes center. The objective of this study was to determine the effect of the EDRP on hospitalization rate, ED utilization rate, glycemic control and expenditures. METHODS: We conducted a single-center analysis of the EDRP cohort (N=420) and compared one year outcomes to historical controls (N=791)...
June 13, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/26968185/expressive-aphasia-as-the-manifestation-of-hyperglycemic-crisis-in-type-2-diabetes
#5
Ji Hyun Lee, Ye An Kim, Joon Ho Moon, Se Hee Min, Young Shin Song, Sung Hee Choi
No abstract text is available yet for this article.
March 12, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/26862997/a-transient-metabolic-recovery-from-early-life-glucose-intolerance-in-cystic-fibrosis-ferrets-occurs-during-pancreatic-remodeling
#6
Yaling Yi, Xingshen Sun, Katherine Gibson-Corley, Weiliang Xie, Bo Liang, Nan He, Scott R Tyler, Aliye Uc, Louis H Philipson, Kai Wang, Manami Hara, Katie Larson Ode, Andrew W Norris, John F Engelhardt
Cystic fibrosis (CF)-related diabetes in humans is intimately related to exocrine pancreatic insufficiency, yet little is known about how these 2 disease processes simultaneously evolve in CF. In this context, we examined CF ferrets during the evolution of exocrine pancreatic disease. At 1 month of age, CF ferrets experienced a glycemic crisis with spontaneous diabetic-level hyperglycemia. This occurred during a spike in pancreatic inflammation that was preceded by pancreatic fibrosis and loss of β-cell mass...
May 2016: Endocrinology
https://www.readbyqxmd.com/read/26765434/bidirectional-relationship-between-diabetes-and-acute-pancreatitis-a-population-based-cohort-study-in-taiwan
#7
COMPARATIVE STUDY
Yi-Kung Lee, Ming-Yuan Huang, Chen-Yang Hsu, Yung-Cheng Su
The proposed bidirectional relationship between acute pancreatitis (AP) and diabetes has never been examined with the same source of data. Furthermore, the effects of disease severity on this relationship have not been fully evaluated. The present study employed the findings from a single database to measure the strength of the association between AP and diabetes.Findings from 1 million National Health Insurance beneficiaries were utilized. Two cohort studies with this database were selected to evaluate the linkage between diabetes and AP...
January 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26733088/pyruvate-dehydrogenase-activity-is-decreased-in-emergency-department-patients-with-diabetic-ketoacidosis
#8
Lars W Andersen, Katherine M Berg, Sophia Montissol, Christopher Sulmonte, Julia Balkema, Michael N Cocchi, Richard E Wolfe, Ashok Balasubramanyam, Xiaowen Liu, Michael W Donnino
OBJECTIVES: The pyruvate dehydrogenase complex (PDH) is an essential enzyme in aerobic metabolism. Ketones are known to inhibit PDH activity, but the extent of this inhibition is unknown in patients with diabetic ketoacidosis (DKA). METHODS: We enrolled adult patients presenting to the emergency department in hyperglycemic crisis. Patients were classified as DKA or hyperglycemia without ketoacidosis based on laboratory criteria. Healthy controls were also enrolled...
June 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/26466492/-perioperative-blood-glucose-control-in-patients-with-diabetic-mellitus
#9
Moritoki Egi
Current criteria used for the diagnosis of diabetic mellitus are (1) HbA(1c) level > 6.5% (National Glycohemoglobin Standardization Program certified methods), (2) fasting glucose concentration > 126 mg x dl(-1) (7.0 mmol x l(-1)), (3) 2-h plasma glucose concentration > 200 mg x dl(-1) (11.1 mmol x l(-1)) during an oral glucose tolerance test, or (4) classic symptoms of hyperglycemia or hyperglycemic crisis with a random plasma glucose concentration > 200 mg x dl(-1) (11.1 mmol x l(-1)). It is reported that 15-20% of perioperative patients were with the presence of diabetic mellitus...
September 2015: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/26319830/-antioxidant-dysfunctionality-of-high-density-lipoproteins-hdl-in-decompensated-diabetic-patients
#10
Fernanda Awad, Susana Contreras-Duarte, Patricia Molina, Verónica Quiñones, Valentina Serrano, Eduardo Abbott, Alberto Maiz, Dolores Busso, Attilio Rigotti
INTRODUCTION: high density lipoproteins (HDL) have important cardiovascular protective effects mediated by their role in reverse cholesterol transport as well as other functional activities, including significant anti-inflammatory and antioxidant properties. It has been shown that HDL anti-inflammatory and antioxidant functions are defective in metabolically stable diabetic patients; however they have not been evaluated during a hyperglycemic crisis. AIM: to determine the antioxidant activity of HDL during a severe diabetic decompensation and to analyze whether this function is restored after resolution of the acute event...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/26252486/trends-in-emergency-department-visit-rates-for-hypoglycemia-and-hyperglycemic-crisis-among-adults-with-diabetes-united-states-2006-2011
#11
Jing Wang, Linda S Geiss, Desmond E Williams, Edward W Gregg
BACKGROUND: Despite concerns about hypoglycemia events from overly aggressive glycemic reduction, population trends in hypoglycemia and hyperglycemic crisis incidence are unclear. To address this gap, we examined changes in emergency department (ED) visit rates for hypoglycemia and hyperglycemic crisis 2006-2011. METHODS: Using data from the Nationwide Emergency Department Sample, we estimated the number of ED visits for hypoglycemia and hyperglycemic crisis via ICD-9-CM among adults with diabetes...
2015: PloS One
https://www.readbyqxmd.com/read/26115971/subsequent-mortality-after-hyperglycemic-crisis-episode-in-the-non-elderly-a-national-population-based-cohort-study
#12
Yuan Kao, Chien-Chin Hsu, Shih-Feng Weng, Hung-Jung Lin, Jhi-Joung Wang, Shih-Bin Su, Chien-Cheng Huang, How-Ran Guo
Hyperglycemic crisis episodes (HCEs)-diabetic ketoacidosis and the hyperosmolar hyperglycemic state-are the most serious acute metabolic complications of diabetes. We aimed to investigate the subsequent mortality after HCE in the non-elderly diabetic which is still unclear. This retrospective national population-based cohort study reviewed, in Taiwan's National Health Insurance Research Database, data from 23,079 non-elder patients (≤65 years) with new-onset diabetes between 2000 and 2002: 7693 patients with HCE and 15,386 patients without HCE (1:2)...
January 2016: Endocrine
https://www.readbyqxmd.com/read/26017647/quality-of-life-of-adolescents-with-type-1-diabetes
#13
Luce Marina F C da Costa, Sandra E Vieira
INTRODUCTION: Diabetes mellitus is a highly prevalent chronic disease. Type 1 diabetes mellitus usually develops during infancy and adolescence and may affect the quality of life of adolescents. OBJECTIVE: To evaluate the quality of life of adolescents with type 1 diabetes mellitus in a metropolitan region of western central Brazil. METHODS: Adolescents aged 10-19 years who had been diagnosed with type 1 diabetes mellitus at least 1 year previously were included...
March 2015: Clinics
https://www.readbyqxmd.com/read/25665811/long-term-mortality-risk-after-hyperglycemic-crisis-episodes-in-geriatric-patients-with-diabetes-a-national-population-based-cohort-study
#14
Chien-Cheng Huang, Shih-Feng Weng, Kang-Ting Tsai, Ping-Jen Chen, Hung-Jung Lin, Jhi-Joung Wang, Shih-Bin Su, Willy Chou, How-Ran Guo, Chien-Chin Hsu
OBJECTIVE: Hyperglycemic crisis is one of the most serious diabetes-related complications. The increase in the prevalence of diabetes in the geriatric population leads to a large disease burden, but previous studies of geriatric hyperglycemic crisis were focused on acute hyperglycemic crisis episode (HCE). This study aimed to delineate the long-term mortality risk after HCE. RESEARCH DESIGN AND METHODS: This retrospective national population-based cohort study reviewed, in Taiwan's National Health Insurance Research Database, data from 13,551 geriatric patients with new-onset diabetes between 2000 and 2002, including 4,517 with HCE (case subjects) (ICD-9 code 250...
May 2015: Diabetes Care
https://www.readbyqxmd.com/read/25568871/editorial-on-the-original-article-entitled-changes-in-diabetes-related-complications-in-the-united-states-1990-2010-published-in-the-new-england-journal-of-medicine-on-april-17-2014
#15
Hala Ahmadieh
The paper entitled "Changes in diabetes-related complications in the United States, 1990-2010" published recently in the New England Journal of Medicine examined the spectrum of diabetes complications over the past 20 years based on a unique, nationally representative database in the Unites States. It was noted that although adults with diagnosis of diabetes have more than tripled between the years 1990 and 2010, the rates of all five major complications of diabetes have declined significantly with the greatest absolute declines being noted for acute myocardial infarction followed by stroke, lower-extremity amputation, end-stage renal disease and finally the death from hyperglycemic crisis...
December 2014: Annals of Translational Medicine
https://www.readbyqxmd.com/read/25497507/quetiapine-induced-hyperglycemic-crisis-and-severe-hyperlipidemia-a-case-report-and-review-of-the-literature
#16
Chris Y Wu, Shanti R Mitchell, Lisa S Seyfried
No abstract text is available yet for this article.
November 2014: Psychosomatics
https://www.readbyqxmd.com/read/25422765/clinical-characteristics-of-hyperglycemic-crises-in-patients-without-a-history-of-diabetes
#17
Willy Chou, Min-Hsien Chung, Hsien-Yi Wang, Jiann-Hwa Chen, Wei-Lung Chen, How-Ran Guo, Hung-Jung Lin, Shih-Bin Su, Chien-Cheng Huang, Chien-Chin Hsu
AIMS/INTRODUCTION: Hyperglycemic crises without a history of diabetes have not been well studied. We compared the clinical characteristics of patients with and without a history of diabetes, and evaluated the glycated hemoglobin levels. MATERIALS AND METHODS: Consecutive adult patients (aged >18 years) visiting the emergency department (ED) between January 2004 and December 2010 were enrolled if they met the criteria for a hyperglycemic crisis. Patients were separated into those without and those with a history of diabetes...
November 2014: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/25244282/hyperglycemic-crisis-precipitated-by-lassa-fever-in-a-patient-with-previously-undiagnosed-type-2-diabetes-mellitus
#18
A E Edo, E Okaka, I U Ezeani
Hyperglycemic crisis (HC) is an acute complication of diabetes mellitus (DM) that is commonly precipitated by infections and non-compliance with therapy. Viral precipitant of HC is uncommon. To report a rare case of HC unmasked by Lassa fever in a patient previously not known to have diabetes mellitus. A 54 year old lady presented with complaints of generalized body weakness, inability to pass stool, and fever. There was no abdominal pain, vomiting and nausea. There were no features of DM. She is not a known case of diabetes mellitus or hypertension...
September 2014: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/25061324/management-of-adult-diabetic-ketoacidosis
#19
REVIEW
Aidar R Gosmanov, Elvira O Gosmanova, Erika Dillard-Cannon
Diabetic ketoacidosis (DKA) is a rare yet potentially fatal hyperglycemic crisis that can occur in patients with both type 1 and 2 diabetes mellitus. Due to its increasing incidence and economic impact related to the treatment and associated morbidity, effective management and prevention is key. Elements of management include making the appropriate diagnosis using current laboratory tools and clinical criteria and coordinating fluid resuscitation, insulin therapy, and electrolyte replacement through feedback obtained from timely patient monitoring and knowledge of resolution criteria...
2014: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/25044235/the-association-of-oxidative-stress-and-pro-inflammatory-cytokines-in-diabetic-patients-with-hyperglycemic-crisis
#20
Juan Li, Minglian Huang, Xingping Shen
AIMS: To investigate the relationship between oxidative stress and serum levels of pro-inflammatory cytokines in diabetic patients with hyperglycemic crisis. METHODS: Seventy-three patients presenting to hospital with diabetic ketoacidosis or non-ketotic hyperglycemia were studied. Superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, total antioxidant capacity (TAC), 8-iso-prostaglandin F2α (8-iso-prostaglandinF2α, 8-iso-PGF2α), tumor necrosis factor receptor-I (TNF-RI), interleukin -1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were measured in all patients...
September 2014: Journal of Diabetes and its Complications
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