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https://www.readbyqxmd.com/read/28432477/usefulness-of-non-magnifying-narrow-band-imaging-in-evis-exera-iii-video-systems-and-high-definition-endoscopes-to-diagnose-dysplasia-in-barrett-s-esophagus-using-the-barrett-international-nbi-group-bing-classification
#1
Oscar Nogales, Arancha Caballero-Marcos, Ana Clemente-Sánchez, Javier García-Lledó, Leticia Pérez-Carazo, Beatriz Merino, Carlos Carbonell, María López-Ibáñez, Cecilia González-Asanza
BACKGROUND: Narrow band imaging (NBI) allows identification of abnormal areas of Barrett's esophagus (BE) and could facilitate targeted biopsies. AIMS: We evaluated the diagnostic accuracy for dysplasia prediction using non-magnifying NBI in Evis Exera III processors and high-definition endoscopes using the Barrett International NBI Group (BING) classification, as well as inter/intraobserver agreement for dysplasia prediction and mucosal/vascular patterns. METHODS: Eight observers (4 staff endoscopists and 4 trainee endoscopists) evaluated 100 images selected from an anonymized bank of 470 photographs using the BING classification...
April 21, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28431912/osteosarcopenic-obesity-prevalence-and-relation-with-frailty-and-physical-performance-in-middle-aged-and-older-women
#2
Claudia Szlejf, Lorena Parra-Rodríguez, Oscar Rosas-Carrasco
OBJECTIVES: The aims of this study were to determine the prevalence of osteosarcopenic obesity (OSO) and to investigate its association with frailty and physical performance in Mexican community-dwelling middle-aged and older women. DESIGN: Cross-sectional analysis of a prospective cohort. SETTING: The FraDySMex study, a 2-round evaluation of community-dwelling adults from 2 municipalities in Mexico City. PARTICIPANTS: Participants were 434 women aged 50 years or older, living in the designated area in Mexico City...
April 18, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28431891/-vulvovaginal-candidiasis-an-old-disease-with-new-challenges
#3
María Soledad Miró, Emilse Rodríguez, Cecilia Vigezzi, Paula Alejandra Icely, Marcelo Gonzaga de Freitas Araújo, Fernando Oscar Riera, Lara Vargas, Claudio Abiega, Juan Pablo Caeiro, Claudia Elena Sotomayor
Vulvovaginal candidiasis is an old disease that, even in a modern world, continues to have a high incidence. Despite the therapeutic advances, treatments are not always effective, and our understanding of the pathogenesis of this fungal infection is still incomplete. A discussion is presented in this article on the most significant developments related to the fungal virulence factors, the role of the immunological mechanisms involved in the vaginal protection, and the genetic alterations that confer susceptibility to the recurrent form of this mycosis...
April 18, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28430821/dietary-dha-epa-ratio-affected-tissue-fatty-acid-profiles-antioxidant-capacity-hematological-characteristics-and-expression-of-lipid-related-genes-but-not-growth-in-juvenile-black-seabream-acanthopagrus-schlegelii
#4
Min Jin, Óscar Monroig, You Lu, Ye Yuan, Yi Li, Liyun Ding, Douglas R Tocher, Qicun Zhou
An 8-week feeding trial was conducted to investigate the effects of dietary docosahexaenoic to eicosapentaenoic acid ratio (DHA/EPA) on growth performance, fatty acid profiles, antioxidant capacity, hematological characteristics and expression of some lipid metabolism related genes of juvenile black seabream (Acanthopagrus schlegelii) of initial weight 9.47 ± 0.03 g. Five isonitrogenous and isolipidic diets (45% crude protein and 14% crude lipid) were formulated to contain graded DHA/EPA ratios of 0.65, 1...
2017: PloS One
https://www.readbyqxmd.com/read/28430387/age-related-reduction-in-the-expression-of-foxo-transcription-factors-and-correlations-with-intervertebral-disc-degeneration
#5
Oscar Alvarez-Garcia, Tokio Matsuzaki, Merissa Olmer, Koichi Masuda, Martin K Lotz
Aging is a main risk factor for intervertebral disc (IVD) degeneration, the main cause of low back pain. FOXO transcription factors are important regulators of tissue homeostasis and longevity. Here, we determined the expression pattern of FOXO in healthy and degenerated human IVD and the associations with IVD degeneration during mouse aging. FOXO expression was assessed by immunohistochemistry in normal and degenerated human IVD samples and in cervical and lumbar IVD from 6, 12, 24, and 36-month-old C57BL/6J mice...
April 21, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28430191/activating-lattice-oxygen-redox-reactions-in-metal-oxides-to-catalyse-oxygen-evolution
#6
Alexis Grimaud, Oscar Diaz-Morales, Binghong Han, Wesley T Hong, Yueh-Lin Lee, Livia Giordano, Kelsey A Stoerzinger, Marc T M Koper, Yang Shao-Horn
Understanding how materials that catalyse the oxygen evolution reaction (OER) function is essential for the development of efficient energy-storage technologies. The traditional understanding of the OER mechanism on metal oxides involves four concerted proton-electron transfer steps on metal-ion centres at their surface and product oxygen molecules derived from water. Here, using in situ (18)O isotope labelling mass spectrometry, we provide direct experimental evidence that the O2 generated during the OER on some highly active oxides can come from lattice oxygen...
May 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28429866/successful-multiple-organ-donation-after-donor-brain-death-due-to-actinomyces-israelii-meningitis
#7
Leonel Lagunes, Oscar Len, Alberto Sandiumenge, Elena Martínez-Saez, Tomás Pumarola, Marta Bodro, Antonio Macías, Jose T Silva, F Xavier Nuvials, Ramon Charco, Francesc Moreso, Teresa Pont
The increasing gap between availability of solid organs for transplantation and the demand has led to the inclusion of donors which according to current guidelines may be discarded, some of them because of the possibility for transmission of infection to their recipients. We present the first report, to the best of our knowledge, of a case of a brain-dead donor with a localized and treated Actinomyces israelii central nervous system infection who, after a thorough evaluation, led to successful transplant procedures in four recipients...
April 21, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28429469/high-body-mass-and-kidney-dysfunction-relate-to-worse-nerve-function-even-in-adults-without-neuropathy
#8
Rens Hanewinckel, M Arfan Ikram, Oscar H Franco, Albert Hofman, Judith Drenthen, Pieter A van Doorn
Polyneuropathy is a prevalent and disabling disorder. Despite extensive evaluation, the cause often remains unknown. Factors that predispose for the development of polyneuropathy need to be identified. We investigated the effect of anthropometric and metabolic factors on peripheral nerve function in 908 participants of the population-based Rotterdam Study without any symptoms or signs of polyneuropathy. Participants underwent nerve conduction studies of the sural and peroneal nerve. Data on age, height, weight, waist circumference, diabetes, lipid levels, hypertension and kidney function were collected...
April 20, 2017: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/28429079/the-r2r3-myb-tt2b-and-the-bhlh-tt8-genes-are-the-major-regulators-of-proanthocyanidin-biosynthesis-in-the-leaves-of-lotus-species
#9
Francisco José Escaray, Valentina Passeri, Ana Perea-García, Cristian Javier Antonelli, Francesco Damiani, Oscar Adolfo Ruiz, Francesco Paolocci
By exploiting interspecific hybrids and their progeny, we identified key regulatory and transporter genes intimately related to proanthocyanidin biosynthesis in leaves of Lotus spp. Proanthocyanidins (PAs), known as condensed tannins, are polymeric flavonoids enriching forage legumes of key nutritional value to prevent bloating in ruminant animals. Unfortunately, major forage legumes such as alfalfa and clovers lack PAs in edible tissues. Therefore, engineering the PA trait in herbage of forage legumes is paramount to improve both ecological and economical sustainability of cattle production system...
April 20, 2017: Planta
https://www.readbyqxmd.com/read/28429020/catalysis-for-fuels-general-discussion
#10
Hans Niemantsverdriet, Pieter van Helden, Emiel Hensen, David Lennon, Katherine Holt, Graham Hutchings, Michael Bowker, Richard Catlow, Mzamo Shozi, Linda Jewell, Michael Claeys, James Hayward, Neil Coville, Nico Fischer, Alberto Roldan, Evjeniy Redekop, Thobani Gambu, Letisha Deeplal, Thabiso Perfect Oscar Mkhwanazi, Kees-Jan Weststrate, Detlef Bahnemann, Matthew Neurock, Hans Schulz, Ding Ma, Simon Kondrat, Paul Collier, Abhishek Kumar Gupta, Avelino Corma, Paul Akomeah, Enrique Iglesia, Eric van Steen, Nora de Leeuw, Moritz Wolf, Tracey van Heerden
No abstract text is available yet for this article.
April 21, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28427527/venous-thromboembolism-in-radiation-therapy-cancer-patients-findings-from-the-riete-registry
#11
REVIEW
Jean-Baptiste Guy, Laurent Bertoletti, Nicolas Magné, Chloé Rancoule, Isabelle Mahé, Carme Font, Oscar Sanz, José Manuel Martín-Antorán, Federica Pace, Jerónimo Ramón Vela, Manuel Monreal
BACKGROUND: Cancer patients are at high risk of venous thromboembolism, particularly during cancer treatment. Conversely to chemotherapy, data on the epidemiology and clinical features of venous thromboembolism during radiation therapy are scarce. There is lack of evidence on the influence of radiation therapy (RT) on outcome in cancer patients with acute venous thromboembolism (VTE). METHODS: We used the RIETE (Registro Informatizado de Enfermedad ThromboEmbolica) database to assess the clinical characteristics and outcome of prospectively-collected consecutive patients with cancer-associated thrombosis occurred during the course of radiation therapy for cancer...
May 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28427294/increased-phagocytic-nadph-oxidase-activity-associates-with-coronary-artery-calcification-in-asymptomatic-men
#12
Oscar Beloqui, María U Moreno, Gorka San José, Álvaro Pejenaute, Adriana Cortés, Manuel F Landecho, Javier Díez, Ana Fortuño, Guillermo Zalba
Vascular calcification is a common feature in atherosclerosis and associates with cardiovascular events. Oxidative stress may be involved in the pathogenesis of vascular calcification. Previous studies have shown that the phagocytic NADPH oxidase is associated with atherosclerosis. The objective of the present study was to investigate the association between phagocytic NADPH oxidase-mediated superoxide production and coronary artery calcium (CAC). NADPH oxidase-mediated superoxide production was determined by chemiluminescence and CAC by computed tomography in 159 asymptomatic men free of overt clinical atherosclerosis...
April 20, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28426835/outcomes-from-a-cohort-of-patients-with-acute-kidney-injury-subjected-to-continuous-venovenous-hemodiafiltration-the-role-of-negative-fluid-balance
#13
Thais Oliveira Claizoni Dos Santos, Marisa Aparecida de Souza Oliveira, Julio Cesar Martins Monte, Marcelo Costa Batista, Virgilio Gonçalves Pereira Junior, Bento Fortunato Cardoso Dos Santos, Oscar Fernando Pavão Santos, Marcelino de Souza Durão Junior
BACKGROUND: Several factors influence the outcomes in acute kidney injury (AKI), especially in intensive care unit (ICU) patients. In this scenario, continuous renal replacement therapies (CRRT) are used to control metabolic derangements and blood volume. Knowing this fact, it may be possible to change the course of the disease and decrease the high mortality rate observed. Thus, we aimed to evaluate the main risk factors for death in AKI patients needing CRRT. RESULTS: This was a prospective, observational cohort study of ICU patients (N = 183) with AKI who underwent continuous venovenous hemodiafiltration (CVVHDF) as their initial dialysis modality choice...
2017: PloS One
https://www.readbyqxmd.com/read/28426702/natalizumab-stabilizes-physical-cognitive-mri-and-oct-markers-of-disease-activity-a-prospective-non-randomized-pilot-study
#14
Garrick D Talmage, Oscar J M Coppes, Adil Javed, Jacqueline Bernard
Natalizumab is an effective therapy for multiple sclerosis (MS). Its effectiveness has been demonstrated in several clinical and imaging studies. The objective of this study was to further demonstrate the efficacy of natalizumab using a comprehensive battery of clinical and imaging markers in the same cohort of patients followed longitudinally, hence capturing the multi-faceted nature of the MS disease process. A prospective, open-label, pilot study of 20 MS patients treated with natalizumab was conducted. High resolution MRI, Symbol-Digit Modalities Test (SDMT), and Optical Coherence Tomography (OCT) scans were obtained at baseline, 48, and 96 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28425849/age-dependent-obesity-and-mitochondrial-dysfunction
#15
Qilong Oscar Yang Li, Ines Soro-Arnaiz, Julián Aragonés
Aging is associated with progressive visceral white adipose tissue (WAT) expansion both in human and mouse. Importantly, WAT enlargement is initiated early in life, suggesting that molecular mechanisms underlying age-dependent obesity are activated at early stages of lifetime. Our recent study found that age-dependent obesity was associated with a specific decline in mitochondrial complex IV activity, which leads to reduced fatty acid oxidation and subsequent adipocyte hypertrophy. At the molecular level, global mitochondrial complex IV inhibition was driven by hypoxia-inducible factor-1α (HIF1α)-mediated repression of some of its key subunits, including cytochrome c oxidase 5b (Cox5b)...
March 15, 2017: Adipocyte
https://www.readbyqxmd.com/read/28424281/distinct-roles-of-vaccinia-virus-nf-kb-inhibitor-proteins-a52-b15-and-k7-in-the-immune-response
#16
Mauro Di Pilato, Ernesto Mejías-Pérez, Carlos Oscar S Sorzano, Mariano Esteban
Poxviruses use a complex strategy to escape immune control, by expressing immunomodulatory proteins that could limit their use as vaccine vectors. To test the role of poxvirus NF-κB pathway inhibitors A52, B15 and K7 in immunity, we deleted their genes in a NYVAC vaccinia virus strain that expresses HIV-1 clade C antigens. After infection of mice, ablation of A52R, B15R and K7R increased dendritic cell, natural killer cell and neutrophil migration as well as chemokine/cytokine expression. Revertant viruses for these genes confirmed their role in inhibiting the innate immune system...
April 19, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28424211/connecting-tubule-glomerular-feedback-mediates-tubuloglomerular-feedback-resetting-post-unilateral-nephrectomy
#17
Sumit R Monu, Yilin Ren, J X Masjoan Juncos, Kristopher Kutskill, Hong Wang, Nitin Kumar, Edward L Peterson, Oscar A Carretero
Unilaterally nephrectomized rats (UNx) have higher glomerular capillary pressure (PGC) that can cause significant glomerular injury in the remnant kidney. PGC is controlled by the ratio of afferent (Af-Art) and efferent arteriole resistance. Af-Art resistance in turn is regulated by two intrinsic feedback mechanisms: 1) Tubuloglomerular feedback (TGF) that causes Af-Art constriction in response to increased NaCl in the macula densa and 2) connecting tubule glomerular feedback (CTGF) that causes Af-Art dilatation in response to an increase in NaCl transport in the connecting tubule via the epithelial sodium channel (ENaC)...
April 19, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28423845/appraising-healthcare-delivery-provision-a-framework-to-model-business-processes
#18
Daniela Luzi, Fabrizio Pecoraro, Oscar Tamburis
Children are dependent on a reliable healthcare system, especially for the delivery of care which crosses the primary/secondary care boundary. A methodology based on UML has been developed to capture and single out meaningful parts of the child healthcare pathways in order to facilitate comparison among 30 EU countries within the MOCHA project. A first application of this methodology has been reported considering asthma management as an example.
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423714/usefulness-of-the-mrp2-promoter-to-overcome-the-chemoresistance-of-gastrointestinal-and-liver-tumors-by-enhancing-the-expression-of-the-drug-transporter-oatp1b1
#19
Elisa Herraez, Laura Sanchez-Vicente, Rocio I R Macias, Oscar Briz, Jose J G Marin
Tumor response to chemotherapy is often limited by drug export through ABC proteins. To overcome this problem, here we have investigated the usefulness of inducing the expression of the multidrug uptake transporter OATP1B1 under the control of the MRP2 promoter (MRP2pr). Human hepatoma cells (Alexander) were transfected with MRP2pr fragments of different length fused to the firefly luciferase ORF in order to select the shortest fragment with the highest response to dexamethasone, which was subsequently used to generate the chimeric construct MRP2pr-OATP1B1-V5...
March 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423672/%C3%AE-2-3-sialyltransferase-type-i-regulates-migration-and-peritoneal-dissemination-of-ovarian-cancer-cells
#20
Kuo-Chang Wen, Pi-Lin Sung, Shie-Liang Hsieh, Yu-Ting Chou, Oscar Kuang-Sheng Lee, Cheng-Wen Wu, Peng-Hui Wang
Epithelial ovarian cancer (EOC) has the highest mortality rate among gynecologic cancers due to advanced stage presentation, peritoneal dissemination, and refractory ascites at diagnosis. We investigated the role of α2,3-sialyltransferase type I (ST3GalI) by analyzing human ovarian cancer datasets and human EOC tissue arrays. We found that high expression of ST3GalI was associated with advanced stage EOC. Transwell migration and cell invasion assays showed that high ST3GalI expression enhanced migration of EOC cells...
March 7, 2017: Oncotarget
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