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https://www.readbyqxmd.com/read/28749590/the-marulu-strategy-2008-2012-overcoming-fetal-alcohol-spectrum-disorder-fasd-in-the-fitzroy-valley
#1
James P Fitzpatrick, June Oscar, Maureen Carter, Elizabeth J Elliott, Jane Latimer, Edie Wright, John Boulton
OBJECTIVE: Aboriginal leaders concerned about high rates of Fetal Alcohol Spectrum Disorder (FASD) in the Fitzroy Valley, remote north-western Australia, introduced restrictions on access to take-away full-strength alcohol. Following this, Aboriginal leaders engaged strategic partners in a broader strategy to address FASD in the region. The aim of this study was to develop and implement a community-led, researcher-supported, FASD strategy. METHODS: A review of literature focusing on community-led FASD strategies identified key components that informed the Marulu FASD strategy...
July 27, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28749548/c-myc-positive-relapsed-and-refractory-diffuse-large-b-cell-lymphoma-impact-of-additional-hits-and-outcomes-with-subsequent-therapy
#2
Narendranath Epperla, Kami J Maddocks, Mohammed Salhab, Julio C Chavez, Nishitha Reddy, Reem Karmali, Elvira Umyarova, Veronika Bachanova, Cristiana Costa, Martha Glenn, Oscar Calzada, Ana C Xavier, Zheng Zhou, Nasheed M Hossain, Francisco J Hernandez-Ilizaliturri, Zeina Al-Mansour, Stefan K Barta, Saurabh Chhabra, Frederick Lansigan, Amitkumar Mehta, Michael V Jaglal, Andrew Evans, Christopher R Flowers, Jonathon B Cohen, Timothy S Fenske, Mehdi Hamadani, Luciano J Costa
BACKGROUND: The impact of MYC proto-oncogene, basic helix-loop-helix (MYC) translocations (with or without additional rearrangements involving the B-cell lymphoma 2 [BCL2] or BCL6 genes) on the response to salvage therapy and survival in patients with diffuse large B-cell lymphoma (DLBCL) who experience primary treatment failure is not well defined. METHODS: This was a multicenter, retrospective study of the impact of MYC, BCL2, and BCL6 rearrangements in patients with DLBCL who failed to achieve complete remission or relapsed within 6 months after they completed upfront chemoimmunotherapy...
July 27, 2017: Cancer
https://www.readbyqxmd.com/read/28749526/adaptation-to-the-spanish-population-of-the-substance-use-risk-profile-scale-surps-and-psychometric-properties
#3
Fermín Fernández-Calderón, Carmen Díaz-Batanero, Antonio J Rojas-Tejada, Natalie Castellanos-Ryan, Óscar M Lozano-Rojas
The identification of different personality risk profiles for substance misuse is useful in preventing substance-related problems. This study aims to test the psychometric properties of a new version of the Substance Use Risk Profile Scale (SURPS) for Spanish college students. Cross-sectional study with 455 undergraduate students from four Spanish universities. A new version of the SURPS, adapted to the Spanish population, was administered with the Beck Hopelessness Scale, the UPPS-P Impulsive Behavior Scale, the State-Trait Anxiety Inventory (STAI) and the Alcohol Use Disorders Identification Test (AUDIT)...
July 14, 2017: Adicciones
https://www.readbyqxmd.com/read/28749525/perceived-barriers-to-implementing-screening-and-brief-intervention-for-alcohol-consumption-by-adolescents-in-hospital-emergency-department-in-spain
#4
María Falcón, Javier Navarro-Zaragoza, Rosa María García-Rodríguez, Daniel Nova-López, María Dulce González-Navarro, María Mercadal, Oscar García-Algar, Aurelio Luna Ruiz-Cabello
BACKGROUND: Screening for alcohol consumption in adolescents is widely justified in the health care field because of the particular vulnerability of this population, which starts drinking alcohol at a very early age and frequently consumes high levels of the same. Hospital emergency departments (ED) could be a good venue to manage early detection and carry out brief intervention (BI) programmes. OBJECTIVES: The aim of this study was to identify perceived barriers for medical staff of three hospitals in Spain to successfully implement a protocol for alcohol detection and BI for minors in the ED...
July 14, 2017: Adicciones
https://www.readbyqxmd.com/read/28749523/questionnaire-of-core-beliefs-related-to-drug-use-and-craving-for-assessment-of-relapse-risk
#5
José Miguel Martínez-González, Raquel Vilar López, Oscar Lozano-Rojas, Antonio Verdejo-García
This study was aimed at designing a questionnaire for the assessment of addiction-related core beliefs and craving. The sample comprised 215 patients (85.8% males and 14.2% females) in treatment for dependence to alcohol (40%), cocaine (36.3%) and cannabis (23.7%). Descriptive statistics were used to characterize the sample. Variance, regression and factorial analyses were conducted to study the questionnaire structure and its relation with variables such as abstinence and craving. Items about drug-related beliefs yielded a four-factor structure: what patient think that they could not do without drug use, lack of withdrawal, conditions required to use drugs again, and use of drugs as the only way to feel good...
July 12, 2017: Adicciones
https://www.readbyqxmd.com/read/28747752/erratum-large-scale-analyses-of-common-and-rare-variants-identify-12-new-loci-associated-with-atrial-fibrillation
#6
Ingrid E Christophersen, Michiel Rienstra, Carolina Roselli, Xiaoyan Yin, Bastiaan Geelhoed, John Barnard, Honghuang Lin, Dan E Arking, Albert V Smith, Christine M Albert, Mark Chaffin, Nathan R Tucker, Molong Li, Derek Klarin, Nathan A Bihlmeyer, Siew-Kee Low, Peter E Weeke, Martina Müller-Nurasyid, J Gustav Smith, Jennifer A Brody, Maartje N Niemeijer, Marcus Dörr, Stella Trompet, Jennifer Huffman, Stefan Gustafsson, Claudia Schurmann, Marcus E Kleber, Leo-Pekka Lyytikäinen, Ilkka Seppälä, Rainer Malik, Andrea R V R Horimoto, Marco Perez, Juha Sinisalo, Stefanie Aeschbacher, Sébastien Thériault, Jie Yao, Farid Radmanesh, Stefan Weiss, Alexander Teumer, Seung Hoan Choi, Lu-Chen Weng, Sebastian Clauss, Rajat Deo, Daniel J Rader, Svati H Shah, Albert Sun, Jemma C Hopewell, Stephanie Debette, Ganesh Chauhan, Qiong Yang, Bradford B Worrall, Guillaume Paré, Yoichiro Kamatani, Yanick P Hagemeijer, Niek Verweij, Joylene E Siland, Michiaki Kubo, Jonathan D Smith, David R Van Wagoner, Joshua C Bis, Siegfried Perz, Bruce M Psaty, Paul M Ridker, Jared W Magnani, Tamara B Harris, Lenore J Launer, M Benjamin Shoemaker, Sandosh Padmanabhan, Jeffrey Haessler, Traci M Bartz, Melanie Waldenberger, Peter Lichtner, Marina Arendt, Jose E Krieger, Mika Kähönen, Lorenz Risch, Alfredo J Mansur, Annette Peters, Blair H Smith, Lars Lind, Stuart A Scott, Yingchang Lu, Erwin B Bottinger, Jussi Hernesniemi, Cecilia M Lindgren, Jorge A Wong, Jie Huang, Markku Eskola, Andrew P Morris, Ian Ford, Alex P Reiner, Graciela Delgado, Lin Y Chen, Yii-Der Ida Chen, Roopinder K Sandhu, Man Li, Eric Boerwinkle, Lewin Eisele, Lars Lannfelt, Natalia Rost, Christopher D Anderson, Kent D Taylor, Archie Campbell, Patrik K Magnusson, David Porteous, Lynne J Hocking, Efthymia Vlachopoulou, Nancy L Pedersen, Kjell Nikus, Marju Orho-Melander, Anders Hamsten, Jan Heeringa, Joshua C Denny, Jennifer Kriebel, Dawood Darbar, Christopher Newton-Cheh, Christian Shaffer, Peter W Macfarlane, Stefanie Heilmann-Heimbach, Peter Almgren, Paul L Huang, Nona Sotoodehnia, Elsayed Z Soliman, Andre G Uitterlinden, Albert Hofman, Oscar H Franco, Uwe Völker, Karl-Heinz Jöckel, Moritz F Sinner, Henry J Lin, Xiuqing Guo, Martin Dichgans, Erik Ingelsson, Charles Kooperberg, Olle Melander, Ruth J F Loos, Jari Laurikka, David Conen, Jonathan Rosand, Pim van der Harst, Marja-Liisa Lokki, Sekar Kathiresan, Alexandre Pereira, J Wouter Jukema, Caroline Hayward, Jerome I Rotter, Winfried März, Terho Lehtimäki, Bruno H Stricker, Mina K Chung, Stephan B Felix, Vilmundur Gudnason, Alvaro Alonso, Dan M Roden, Stefan Kääb, Daniel I Chasman, Susan R Heckbert, Emelia J Benjamin, Toshihiro Tanaka, Kathryn L Lunetta, Steven A Lubitz, Patrick T Ellinor
No abstract text is available yet for this article.
July 27, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28747386/the-association-of-autoimmune-thyroid-disease-aitd-with-psoriatic-disease-a-prospective-cohort-study-systematic-review-and-meta-analysis
#7
Samer R Khan, Arjola Bano, Marlies Wakkee, Tim Korevaar, Oscar Franco, Tamar Nijsten, Robin P Peeters, L Chaker
Objective Autoimmune thyroid disease (AITD) and psoriatic disease share auto-immunological components. Few studies have investigated the link between both, yielding inconclusive results. Design We assessed the association of AITD with psoriatic disease in a prospective cohort study, and performed a systematic review and meta-analysis. Methods 8,214 participants of the Rotterdam Study (RS) with thyroid peroxidase antibodies (TPO-Abs), thyroid stimulating hormone (TSH) and/or free thyroxine (FT4) measurements and information on psoriatic disease were included...
July 26, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28746941/occurrence-of-cranial-neoplasms-in-pediatric-patients-with-noonan-syndrome-receiving-growth-hormone-is-screening-with-brain-mri-prior-to-initiation-of-growth-hormone-indicated
#8
Kanthi Bangalore Krishna, Pedro Pagan, Oscar Escobar, Jadranka Popovic
Noonan syndrome (NS) is associated with short stature. Growth hormone treatment has been FDA approved for use in these patients. Children with NS are at a higher risk of developing benign and malignant proliferative disorders, primary brain tumors being one of them. Since growth hormone therapy can worsen the tumor burden, screening with a brain MRI prior to growth hormone initiation in NS patients is strongly recommended. Here we present two NS patients who developed different primary brain tumors while being on growth hormone therapy...
July 26, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28746746/outcomes-of-patients-with-metastatic-phaeochromocytoma-and-paraganglioma-a-systematic-review-and-meta-analysis
#9
Oksana Hamidi, William F Young, Lucinda Gruber, John Smestad, Qi Yan, Oscar J Ponce, Larry Prokop, M Hassan Murad, Irina Bancos
OBJECTIVE: The outcomes of patients with metastatic phaeochromocytoma (PHEO) and paraganglioma (PGL) are unclear. We performed a systematic review and meta-analysis of baseline characteristics and mortality rates of patients with metastatic PHEO and PGL (PPGL). DESIGN: Ovid Medline In-Process & Other Non-Indexed Citations, Ovid MEDLINE, Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, Scopus, Web of Science, and references of key articles were searched from inception to 2016...
July 26, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28746709/association-of-coronary-artery-calcium-score-vs-age-with-cardiovascular-risk-in-older-adults-an-analysis-of-pooled-population-based-studies
#10
Yuichiro Yano, Christopher J O'Donnell, Lewis Kuller, Maryam Kavousi, Raimund Erbel, Hongyan Ning, Ralph D'Agostino, Anne B Newman, Khurram Nasir, Albert Hofman, Nils Lehmann, Klodian Dhana, Ron Blankstein, Udo Hoffmann, Stefan Möhlenkamp, Joseph M Massaro, Amir-Abbas Mahabadi, Joao A C Lima, M Arfan Ikram, Karl-Heinz Jöckel, Oscar H Franco, Kiang Liu, Donald Lloyd-Jones, Philip Greenland
Importance: Besides age, other discriminators of atherosclerotic cardiovascular disease (ASCVD) risk are needed in older adults. Objectives: To examine the predictive ability of coronary artery calcium (CAC) score vs age for incident ASCVD and how risk prediction changes by adding CAC score and removing only age from prediction models. Design, Setting, and Participants: We conducted an analysis of pooled US population-based studies, including the Framingham Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Cardiovascular Health Study...
July 26, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28745241/the-role-of-innate-immune-system-receptors-in-epilepsy-research
#11
Oscar Arias-Carrion
Epilepsy is one of the most complex neurological disorders whose study requires a broad knowledge of neurology and neuroscience. It comprises a diverse group of neurological disorders that share the central feature of spontaneous recurrent seizures, and are often accompanied by cognitive deficits and mood disorder. This condition is one of the most common neurological disorders. Until recently, alterations of neuronal activities had been the focus of epilepsy research. This neurocentric emphasis did not address issues that arise in more complex models of epileptogenesis...
July 25, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28744991/utility-of-high-density-multielectrode-mapping-during-ablation-of-scar-related-ventricular-tachycardia
#12
Óscar Cano, Diego Plaza, Assumpció Saurí, Joaquín Osca, Pau Alonso, Ana Andrés, María-José Sancho-Tello, Luis Martínez-Dolz
INTRODUCTION: Multielectrode mapping catheters (MEMC) allow the performance of high resolution and density maps but the utility of these catheters in ventricular tachycardia (VT) ablation procedures has not been yet widely described. We sought to evaluate the utility of a MEMC during scar-related VT ablation procedures. METHODS: 85 consecutive scar-related VT ablation procedures were performed in 81 patients. In the first 26 procedures, a standard 3.5 mm tip linear catheter was employed for endocardial/epicardial mapping (control group)...
July 26, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28744124/fast-degrading-pla-ormoglass-fibrous-composite-scaffold-leads-to-a-calcium-rich-angiogenic-environment
#13
Nadège Sachot, Agata Roguska, Josep Anton Planell, Malgorzata Lewandowska, Elisabeth Engel, Oscar Castaño
The success of scaffold implantation in acellular tissue engineering approaches relies on the ability of the material to interact properly with the biological environment. This behavior mainly depends on the design of the graft surface and, more precisely, on its capacity to biodegrade in a well-defined manner (nature of ions released, surface-to-volume ratio, dissolution profile of this release, rate of material resorption, and preservation of mechanical properties). The assessment of the biological behavior of temporary templates is therefore very important in tissue engineering, especially for composites, which usually exhibit complicated degradation behavior...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28743283/spatial-population-dynamics-and-temporal-analysis-of-the-distribution-of-lutzomyia-longipalpis-lutz-neiva-1912-diptera-psychodidae-phlebotominae-in-the-city-of-clorinda-formosa-argentina
#14
Andrea Gómez-Bravo, Alba German, Marcelo Abril, Marcelo Scavuzzo, Oscar D Salomón
BACKGROUND: Lutzomyia longipalpis, the vector for the causal agent of visceral leishmaniasis (VL), has extended its distribution in the southern cone in the Americas. The first urban record of Lu. longipalpis in Argentina was from the City of Clorinda in 2004. The aim of this study was to analyse the monthly distribution and abundance of Lu. longipalpis and to evaluate its association with environmental and climatic variables in Clorinda City, Province of Formosa. METHODS: Phlebotominae sampling was performed using CDC light mini-traps that were placed in different sites of the city between January 2012 and December 2013...
July 25, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28742857/dna-immunisation-with-dengue-virus-e-protein-domains-i-ii-but-not-domain-iii-enhances-zika-west-nile-and-yellow-fever-virus-infection
#15
Jose L Slon Campos, Monica Poggianella, Sara Marchese, Monica Mossenta, Jyoti Rana, Francesca Arnoldi, Marco Bestagno, Oscar R Burrone
Dengue virus (DENV), the causative agent of dengue disease, is among the most important mosquito-borne pathogens worldwide. DENV is composed of four closely related serotypes and belongs to the Flaviviridae family alongside other important arthropod-borne viral pathogens such as Zika virus (ZIKV), West Nile virus (WNV) and Yellow Fever virus (YFV). After infection, the antibody response is mostly directed to the viral E glycoprotein which is composed of three structural domains named DI, DII and DIII that share variable degrees of homology among different viruses...
2017: PloS One
https://www.readbyqxmd.com/read/28739370/molecular-systematics-species-delimitation-and-diversification-patterns-of-the-phyllodactylus-lanei-complex-gekkota-phyllodactylidae-in-mexico
#16
Tonatiuh Ramírez-Reyes, Daniel Piñero, Oscar Flores-Villela, Ella Vázquez-Domínguez
The description of cryptic gecko species worldwide has revealed both that many putative species are, in fact, conformed by a complex of morphologically conserved species that are genetically distinct and highly divergent, and that gecko species diversity could be underestimated. The taxonomy and species delimitation of geckos belonging to the genus Phyllodactylus is still controversial, 16 of which are distributed in Mexico and 13 are endemic. Although the large morphological variation shown by the Phyllodactylus species from Mexico has been amply documented, little is known about their genetic diversity and evolutionary relationships, and much less regarding cryptic speciation...
July 21, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28738504/prevention-of-melanin-formation-during-aryl-alcohol-oxidase-production-under-growth-limited-conditions-using-an-aspergillus-nidulans-cell-factory
#17
Oscar Pardo-Planas, Rolf A Prade, Michael Müller, Hasan K Atiyeh, Mark R Wilkins
An Aspergillus nidulans cell factory was genetically engineered to produce an aryl alcohol oxidase (AAO). The cell factory initiated production of melanin when growth-limited conditions were established using stationary plates and shaken flasks. This phenomenon was more pronounced when the strain was cultured in a trickle bed reactor (TBR). This study investigated different approaches to reduce melanin formation in fungal mycelia and liquid medium in order to increase the enzyme production yield. Removal of copper from the medium recipe reduced melanin formation in agar cultures and increased enzyme activities by 48% in agitated liquid cultures...
July 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28737563/reverse-distal-transverse-palmar-arch-in-distal-digital-replantation
#18
Ching-Yueh Wei, Oscar Orozco, Gustavo Vinagre, Mark Shafarenko
BACKGROUND: Refinements in microsurgery have made distal finger replantation an established technique with high success rates and good functional and aesthetic outcomes. However, it still represents a technically demanding procedure due to the small vessel caliber and frequent lack of vessel length, requiring the use of interpositional venous grafts in some instances. We describe a new technique for anastomosis in fingertip replantation, whereby the need for venous grafts is eliminated...
July 22, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28736063/bladder-cancer-present-and-future
#19
REVIEW
Roberto Hugo Martinez Rodriguez, Oscar Buisan Rueda, Luis Ibarz
Bladder cancer has a high incidence and involves high associated morbidity and mortality. Since its initial clinical suspicion, early diagnostic confirmation and multimodal treatment involve different medical specialties. For this reason, we consider it important to spread the current consensus for its management. Recent advances in immunology and Chemotherapy make it necessary to expose and reflect on future perspectives.
July 20, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28736061/short-term-reconsultation-hospitalisation-and-death-rates-after-discharge-from-the-emergency-department-in-patients-with-acute-heart-failure-and-analysis-of-the-associated-factors-the-altur-ica-study
#20
Òscar Miró, Víctor Gil, Francisco Javier Martín-Sánchez, Pablo Herrero, Javier Jacob, Carolina Sánchez, Carolina Xipell, Sira Aguiló, Pere Llorens
BACKGROUND AND OBJECTIVES: The aim of this study was to define the following in patients with acute heart failure (AHF) discharged directly from accident and emergency (A&E): rates of reconsultation to A&E and hospitalisation for AHF, and all-cause death at 30 days, rate of combined event at 7 days and the factors associated with these rates. PATIENTS AND METHOD: The study included patients consecutively diagnosed with AHF during 2 months in 27 Spanish A&E departments who were discharged from A&E without hospitalisation...
July 20, 2017: Medicina Clínica
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