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Quintin Sheridan, Seungmin Oh, Oscar Morales-Collazo, Edward W Castner, Joan Frances Brennecke, Edward J Maginn
A combination of X-ray scattering experiments and molecular dynamics simulations were conducted to investigate the structure of ionic liquids (ILs) which chemically bind CO2. The structure functions were measured and computed for four different ILs consisting of two different phosphonium cations, triethyloctylphosphonium ([P2228](+)) and trihexyltetradecylphosphonium ([P66614](+)), paired with two different aprotic heterocyclic anions which chemically react with CO2, 2-cyanopyrrolide and 1,2,4-triazolide. Simulations were able to reproduce to a reasonable degree the experimental structure functions, and by deconstructing the simulated structure functions, further information on the liquid structure was obtained...
October 26, 2016: Journal of Physical Chemistry. B
Sheila Cardeña-Núñez, Luis Óscar Sánchez-Guardado, Rubén Corral-San-Miguel, Lucía Rodríguez-Gallardo, Faustino Marín, Luis Puelles, Pilar Aroca, Matías Hidalgo-Sánchez
The vertebrate inner ear is a complex three-dimensional sensorial structure with auditory and vestibular functions. The molecular patterning of the developing otic epithelium creates various positional identities, consequently leading to the stereotyped specification of each neurosensory and non-sensory element of the membranous labyrinth. The Iroquois (Iro/Irx) genes, clustered in two groups (A: Irx1, Irx2, and Irx4; and B: Irx3, Irx5, and Irx6), encode for transcriptional factors involved directly in numerous patterning processes of embryonic tissues in many phyla...
October 25, 2016: Brain Structure & Function
Oscar Marín
There is a growing understanding that pathological genetic variation and environmental insults during sensitive periods in brain development have long-term consequences on brain function, which range from learning disabilities to complex psychiatric disorders such as schizophrenia. Furthermore, recent experiments in animal models suggest that therapeutic interventions during sensitive periods, typically before the onset of clear neurological and behavioral symptoms, might prevent or ameliorate the development of specific pathologies...
October 26, 2016: Nature Medicine
Sergio Agudelo, Oscar Gamboa, Fabio Rodríguez, Sandra Cala, Nathalie Gualdrón, Evelyn Obando, María Lucía Padrón
BACKGROUND: Human lactancy is a simple and cost-effective strategy that influences infant and maternal mortality rates. Skin-to-skin contact (SSC) is an immediate postpartum period strategy that has proven to benefit the initiation and continuation of human lactation and to decrease hospitalization during the first week of life. This study aims to determine the effect of SSC initiation at birth (immediate versus early) in healthy, full-term newborns treated at the Universidad de La Sabana Clinic on the duration of exclusive human lactation...
October 26, 2016: Trials
Ewa Kasprzycka, Victor A Trush, Vladimir M Amirkhanov, Lucjan Jerzykiewicz, Oscar L Malta, Janina Legendziewicz, Paula Gawryszewska
A series of stable lanthanide complexes Na[Ln(L)4] (Ln = La3+, Eu3+, Gd3+, Tb3+, L = [L1]-, [L2]-), with dimethyl(4-methylphenylsulfonyl)amidophosphate (HL1) and dimethyl 2-naphthylsulfonylamidophosphate (HL2), here denoted as 1Ln, 2Ln, as well as sodium salts, NaL, denoted as 1Na, 2Na were synthesized. The compounds were characterized by single-crystal X-ray diffraction, IR, absorption and emission spectroscopies at 293 and 77 K. In contrast to the usual and well known dominant role of the ligand triplet state in intramolecular energy transfer processes in Ln complexes, in this particular new class of Ln compounds with sulphonylamidophosphate ligands we discuss, for the first time, the strong experimental and detailed theoretical evidences that suggest a dominant role played by the ligand first excited singlet state...
October 25, 2016: Chemistry: a European Journal
Oscar A Debats, Ansje S Fortuin, Hanneke J M Meijer, Thomas Hambrock, Geert J S Litjens, Jelle O Barentsz, Henkjan J Huisman
OBJECTIVES: The key to MR lymphography is suppression of T2* MR signal in normal lymph nodes, while retaining high signal in metastatic nodes. Our objective is to quantitatively compare the ability of ferumoxtran-10 and ferumoxytol to suppress the MR signal in normal pelvic lymph nodes. METHODS: In 2010, a set of consecutive patients who underwent intravenous MR Lymphography (MRL) were included. Signal suppression in normal lymph nodes in T2*-weighted images due to uptake of USPIO (Ultra-Small Superparamagnetic Particles of Iron Oxide) was quantified...
2016: PeerJ
José Javier Jareño-Esteban, M Ángeles Muñoz-Lucas, Óscar Gómez-Martín, Sergio Utrilla-Trigo, Carlos Gutiérrez-Ortega, Antonio Aguilar-Ros, Luis Collado-Yurrita, Luis Miguel Callol-Sánchez
INTRODUCTION: A major risk factor for chronic obstructive pulmonary disease (COPD) is tobacco smoke, which generates oxidative stress in airways, resulting in the production of volatile organic compounds (VOC). The purpose of this study was to identify VOCs in exhaled breath and to determine their possible use as disease biomarkers. METHOD: Exhaled breath from 100 healthy volunteers, divided into 3groups (never smokers, former smokers and active smokers) and exhaled breath from 57 COPD patients were analyzed...
October 22, 2016: Archivos de Bronconeumología
Massimo Arcerito, Eric Changchien, Oscar Bernal, Adam Konkoly-Thege, John Moon
Laparoscopic inguinal hernia repair has been shown to have multiple advantages compared with open repair such as less postoperative pain and earlier resume of daily activities with a comparable recurrence rate. We speculate robotic inguinal hernia repair may yield equivalent benefits, while providing the surgeon added dexterity. One hundred consecutive robotic inguinal hernia repairs with mesh were performed with a mean age of 56 years (25-96). Fifty-six unilateral hernias and 22 bilateral hernias were repaired amongst 62 males and 16 females...
October 2016: American Surgeon
Simona Sobrero, Eva Pagano, Elisa Piovano, Lorenzo Bono, Manuela Ceccarelli, Anna Ferrero, Chiara Macchi, Marinella Mistrangelo, Silvia Patriarca, Elisa Tripodi, Roberto Zanetti, Oscar Bertetto, Giovannino Ciccone, Paolo Zola
BACKGROUND: In the northwestern Italian region of Piedmont, current statistics on hospitalizations show that surgical treatment for ovarian cancer (OC) is taking place in many small hospitals, as opposed to a more centralized approach. A population-based clinical audit was promoted to investigate whether OC is being managed according to clinical guidelines, identify determinants of lack of adherence to guidelines, and evaluate the association between adherence to guidelines and survival...
November 2016: International Journal of Gynecological Cancer
Antonio J Salazar, Javier A Romero, Oscar A Bernal, Angela P Moreno, Sofía C Velasco, Xavier A Díaz
Objective. The aim of this study was to evaluate and compare the clinical performance of different alternatives to implement low-cost screening telemammography. We compared computed radiography, film printed images, and digitized films produced with a specialized film digitizer and a digital camera. Material and Methods. The ethics committee of our institution approved this study. We assessed the equivalence of the clinical performance of observers for cancer detection. The factorial design included 70 screening patients, four technological alternatives, and cases interpreted by seven radiologists, for a total of 1,960 observations...
2016: International Journal of Telemedicine and Applications
Oscar H Del Brutto, Robertino M Mera, Mauricio Zambrano, Victor J Del Brutto
BACKGROUND: There is no information on stroke incidence in rural areas of Latin America, where living conditions and cardiovascular risk factors are different from urban centers. AIM: Using a population-based prospective cohort study design, we aimed to assess risk factors influencing stroke incidence in community-dwelling adults living in rural Ecuador. METHODS: First-ever strokes occurring from 1 June 2012 to 31 May 2016, in Atahualpa residents aged ≥40 years, were identified from yearly door-to-door surveys and other overlapping sources...
October 24, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
Ardashel Latsuzbaia, Vincent W V Jaddoe, Albert Hofman, Oscar H Franco, Janine F Felix
Lipid concentrations are heritable traits. Recently, the number of known genetic loci associated with lipid levels in adults increased from 95 to 157. The effects of these 157 loci have not been tested in children. Considering that lipid levels track from childhood to adulthood, we studied whether these variants already affect lipid concentrations in a large group of 2645 children with a median age of 6.0 years (95% range 5.7-7.3) from the population-based Generation R Study. 28 single nucleotide polymorphisms (SNPs) associated with triglycerides (TG), 39 SNPs associated with total cholesterol (TC), 28 SNPs associated with low density lipoprotein cholesterol (LDL-C), and 56 SNPs associated with high density lipoprotein cholesterol (HDL-C) were analyzed individually and combined into genetic risk scores...
October 24, 2016: Journal of Lipid Research
Yücel Korkusuz, Oscar Maximilian Mader, Wolfgang Kromen, Christian Happel, Shadi Ahmad, Daniel Gröner, Mithat Koca, Alexander Mader, Frank Grünwald, Hüdayi Korkusuz
OBJECTIVE: To evaluate if internally cooled microwave ablation (cMWA) is a safe and effective method for treatment of benign and malign thyroid nodules. METHODS: 9 patients with 11 symptomatic cold benign thyroid nodules and 1 recurrent thyroid carcinoma ranging in volume from 9.1 to 197ml (mean size 52± 57ml) were treated with cMWA. The mean age of the patients was 59 years. Pain during the treatment was measured on a 10-point scale. Side effects revealed by ultrasound or patients' complaints were documented...
November 2016: European Journal of Radiology
Pierre Russo, John C Magee, Robert A Anders, Kevin E Bove, Catherine Chung, Oscar W Cummings, Milton J Finegold, Laura S Finn, Grace E Kim, Mark A Lovell, Margret S Magid, Hector Melin-Aldana, Sarangarajan Ranganathan, Bahig M Shehata, Larry L Wang, Frances V White, Zhen Chen, Catherine Spino
The liver biopsy guides diagnostic investigation and therapy in infants with undiagnosed cholestasis. Histologic features in the liver may also have prognostic value in the patient with biliary atresia (BA). We assessed the relative value of histologic features in 227 liver needle biopsies in discriminating between BA and other cholestatic disorders in infants enrolled in a prospective Childhood Liver Disease Research Network (ChiLDReN) cohort study by correlating histology with clinical findings in infants with and without BA...
October 21, 2016: American Journal of Surgical Pathology
Oscar Patterson-Lomba, Muntaser Safan, Sherry Towers, Jay Taylor
Urban areas, with large and dense populations, offer conditions that favor the emergence and spread of certain infectious diseases. One common feature of urban populations is the existence of large socioeconomic inequalities which are often mirrored by disparities in access to healthcare. Recent empirical evidence suggests that higher levels of socioeconomic inequalities are associated with worsened public health outcomes, including higher rates of sexually transmitted diseases (STD's) and lower life expectancy...
October 1, 2016: Mathematical Biosciences and Engineering: MBE
Oscar H Del Brutto, Robertino M Mera
Epilepsy is a major health issue in rural areas of developing countries. However, heterogeneity of epilepsy prevalence in different studies precludes assessment of the magnitude of the problem. Using similar protocols, two population-based surveys were conducted 12 years apart (2003 and 2015) in a rural Ecuadorian village (Atahualpa). The only difference was a higher people compliance with interviewers during the second survey. Epilepsy prevalence in the 2003 survey was 13.5 per 1,000 (18/1,332) in villagers aged ≥20 years...
October 24, 2016: Epilepsia
Jason M Law, Sebastian C Stark, Ke Liu, Norah E Liang, Mahmud M Hussain, Matthias Leiendecker, Daisuke Ito, Oscar Verho, Andrew M Stern, Stephen E Johnston, Yan-Ling Zhang, Gavin P Dunn, Alykhan F Shamji, Stuart L Schreiber
Evidence suggests that specific mutations of isocitrate dehydrogenases 1 and 2 (IDH1/2) are critical for the initiation and maintenance of certain tumor types and that inhibiting these mutant enzymes with small molecules may be therapeutically beneficial. In order to discover mutant allele-selective IDH1 inhibitors with chemical features distinct from existing probes, we screened a collection of small molecules derived from diversity-oriented synthesis. The assay identified compounds that inhibit the IDH1-R132H mutant allele commonly found in glioma...
October 13, 2016: ACS Medicinal Chemistry Letters
Oscar J Ingham, Ronald M Paranal, William B Smith, Randolph A Escobar, Han Yueh, Tracy Snyder, John A Porco, James E Bradner, Aaron B Beeler
A novel, isoform-selective inhibitor of histone deacetylase 8 (HDAC8) has been discovered by the repurposing of a diverse compound collection. Medicinal chemistry optimization led to the identification of a highly potent (0.8 nM) and selective inhibitor of HDAC8.
October 13, 2016: ACS Medicinal Chemistry Letters
Sergio E Galindo, Pablo Toharia, Oscar D Robles, Luis Pastor
After decades of independent morphological and functional brain research, a key point in neuroscience nowadays is to understand the combined relationships between the structure of the brain and its components and their dynamics on multiple scales, ranging from circuits of neurons at micro or mesoscale to brain regions at macroscale. With such a goal in mind, there is a vast amount of research focusing on modeling and simulating activity within neuronal structures, and these simulations generate large and complex datasets which have to be analyzed in order to gain the desired insight...
2016: Frontiers in Neuroinformatics
Oscar Heredia Díaz, José Luis Aldaba Meza, Baltazar M Baltazar, Germán Bojórquez Bojórquez, Luciano Castro Espinoza, José Luis Corrales Madrid, Juan Manuel de la Fuente Martínez, Héctor Abel Durán Pompa, José Alonso Escobedo, Armando Espinoza Banda, José Antonio Garzón Tiznado, Juvencio González García, José Luis Guzmán Rodríguez, Jesús Ignacio Madueño Martínez, José Luis Martínez Carrillo, Chen Meng, Francisco Javier Quiñones Pando, Enrique Rosales Robles, Ignacio Ruiz Hernández, José Elías Treviño Ramírez, Hugo Raúl Uribe Montes, Francisco Zavala García
Environmental risk assessment (ERA) of genetically modified (GM) crops is a process to evaluate whether the biotechnology trait(s) in a GM crop may result in increased pest potential or harm to the environment. In this analysis, two GM insect-resistant (IR) herbicide-tolerant maize hybrids (MON-89Ø34-3 × MON-88Ø17-3 and MON-89Ø34-3 × MON-ØØ6Ø3-6) and one herbicide-tolerant GM hybrid (MON-ØØ6Ø3-6) were compared with conventional maize hybrids of similar genetic backgrounds. Two sets of studies, Experimental Phase and Pilot Phase, were conducted across five ecological regions (ecoregions) in Mexico during 2009-2013, and data were subject to meta-analysis...
October 22, 2016: Transgenic Research
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