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Tms and mtbi

Alia L Yasen, David R Howell, Li-Shan Chou, Angela M Pazzaglia, Anita D Christie
PURPOSE: To prospectively examine the association between intracortical inhibition and functional recovery following mild traumatic brain injury (mTBI). METHODS: Twenty individuals with mTBI and twenty matched control participants were assessed using transcranial magnetic stimulation (TMS), the Attentional Network Test (ANT), and gait analysis. Hierarchical linear modeling was used to longitudinally examine potential differences between groups and relationships in the pattern of recovery in cortical silent period (CSP) duration, cognitive reaction time, and single and dual-task walking speeds across 5 testing time points...
January 24, 2017: Medicine and Science in Sports and Exercise
Trevor A Seeger, Adam Kirton, Michael J Esser, Clare Gallagher, Jeff Dunn, Ephrem Zewdie, Omar Damji, Patrick Ciechanski, Karen M Barlow
INTRODUCTION: Mild traumatic brain injury (mTBI) outcomes are variable, and 10-15% may suffer from prolonged symptoms beyond 3 months that impair the child's return to normal activities. Neurophysiological mechanisms of mTBI are incompletely understood, particularly in children, but alterations in cortical excitability have been proposed to underlie post-concussion syndrome. Improved understanding is required to advance interventions and improve outcomes. OBJECTIVE/HYPOTHESIS: To determine if cortical excitability is altered in children with mTBI, and its association with clinical symptoms...
March 2017: Brain Stimulation
Skadi Wilke, Jonathan List, Ralf Mekle, Robert Lindenberg, Martin Bukowski, Stefanie Ott, Florian Schubert, Bernd Ittermann, Agnes Flöel
BACKGROUND AND PURPOSE: In patients in the chronic phase after recurrent mild traumatic brain injury (mTBI), alterations in gamma-aminobutyric acid (GABA) concentration and receptor activity have been reported, possibly mediating subtle but persistent cognitive deficits and increased rate of dementia in older age. Here, we evaluated whether anodal transcranial direct current stimulation (atDCS) over the primary motor cortex reduces GABA concentration and GABAB receptor activity in patients with recurrent mTBI...
July 8, 2016: Journal of Neurotrauma
Geneviève Lefebvre, Sara Tremblay, Hugo Théoret
PRIMARY OBJECTIVE: The present paper systematically reviews studies using transcranial magnetic stimulation (TMS) over the primary motor cortex (M1) to assess cortical excitability, intra-cortical inhibition/facilitation and synaptic plasticity following mild traumatic brain injury (mTBI). METHODS: Articles using TMS over M1 in patients with mTBI or sport-related concussion indexed in PubMed and published between 1998 and September 2014 were included in the present review...
2015: Brain Injury: [BI]
Brendan P Major, Mark A Rogers, Alan J Pearce
Mild traumatic brain injury (mTBI) and sports concussion are a growing public health concern, with increasing demands for more rigorous methods to quantify changes in the brain post-injury. Electrophysiology, and in particular, transcranial magnetic stimulation (TMS), have been demonstrated to provide prognostic value in a range of neurological conditions; however, no review has quantified the efficacy of TMS in mTBI/concussion. In the present study, we present a systematic review and critical evaluation of the scientific literature from 1990 to 2014 that has used TMS to investigate corticomotor excitability responses at short-term (< 12 months), medium-term (1-5 years), and long-term (> 5 years) post-mTBI/concussion...
April 2015: Clinical and Experimental Pharmacology & Physiology
Amy A Herrold, Sandra L Kletzel, Brett C Harton, R Andrew Chambers, Neil Jordan, Theresa Louise-Bender Pape
Alcohol use disorder (AUD), mild traumatic brain injury (mTBI), and posttraumatic stress disorder (PTSD) commonly co-occur (AUD + mTBI + PTSD). These conditions have overlapping symptoms which are, in part, reflective of overlapping neuropathology. These conditions become problematic because their co-occurrence can exacerbate symptoms. Therefore, treatments must be developed that are inclusive to all three conditions. Repetitive transcranial magnetic stimulation (rTMS) is non-invasive and may be an ideal treatment for co-occurring AUD + mTBI + PTSD...
October 1, 2014: Neural Regeneration Research
Mark S George, Rema Raman, David M Benedek, Christopher G Pelic, Geoffrey G Grammer, Karen T Stokes, Matthew Schmidt, Chad Spiegel, Nancy Dealmeida, Kathryn L Beaver, Jeffrey J Borckardt, Xiaoying Sun, Sonia Jain, Murray B Stein
BACKGROUND: Suicide attempts and completed suicides are common, yet there are no proven acute medication or device treatments for treating a suicidal crisis. Repeated daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) for 4-6 weeks is a new FDA-approved treatment for acute depression. Some open-label rTMS studies have found rapid reductions in suicidality. DESIGN: This study tests whether a high dose of rTMS to suicidal inpatients is feasible and safe, and also whether this higher dosing might rapidly improve suicidal thinking...
May 2014: Brain Stimulation
Mohan Krishnan, Nichole Smith, Jacobus Donders
The Tower of London - Drexel University, Second Edition (TOL(DX)) was investigated in order to determine the efficacy of using this instrument in evaluating the impact of traumatic brain injury on cognitive functioning in adults. Performance on the TOL(DX) was compared among 56 individuals with complicated mild to severe traumatic brain injury ("sTBI"), 68 individuals with uncomplicated, mild traumatic brain injury ("mTBI"), and 124 demographically matched, healthy controls. Both TBI groups performed worse than controls on TOL(DX) measures of executive time (ET) and number of moves used (TMS), but only patients with sTBI were more likely to be impaired on TMS (i...
2012: Clinical Neuropsychologist
Shahid Bashir, Marine Vernet, Woo-Kyoung Yoo, Ilan Mizrahi, Hugo Theoret, Alvaro Pascual-Leone
PURPOSE: Even after a mild traumatic brain injury (TBI) symptoms may be long lasting and never resolve completely. The neurophysiologic substrate for such lasting deficits remains unclear. There is a lack of objective measures of early brain abnormalities following mild TBI, which could shed light on the genesis of these lasting impairments. METHODS: Here we report findings in a previously healthy man tested 2 and 6 weeks after a well-documented concussion. Findings were compared with 12 control subjects...
2012: Restorative Neurology and Neuroscience
J Tallus, P Lioumis, H Hämäläinen, S Kähkönen, O Tenovuo
OBJECTIVES: Mild traumatic brain injury (mTBI) is very common, and part of the patients experience persistent symptoms. These may be caused by diffuse neuronal damage and could therefore affect cortical excitability. The motor threshold (MT), measured by transcranial magnetic stimulation (TMS), is a measure of cortical excitability and cortico-spinal tract integrity. MATERIALS AND METHODS: We used navigated TMS (nTMS) and electromyography to determine subjects' left hemisphere MTs...
September 2012: Acta Neurologica Scandinavica
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