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Tms and tbi

Hannah L Coyle, Jennie Ponsford, Kate E Hoy
The pathophysiology associated with mild traumatic brain injury (mTBI) includes neurometabolic and cytoskeletal changes that have been shown to impair structural and functional connectivity. Evidence that persistent neuropsychological impairments post injury are linked to structural and functional connectivity changes is increasing. However, to date the relationship between connectivity changes, heterogeneity of persistent symptoms and recovery post mTBI has been poorly characterised. Recent innovations in neuroimaging provide new ways of exploring connectivity changes post mTBI...
June 6, 2018: Neuroscience and Biobehavioral Reviews
Virginia Conde, Sara Hesby Andreasen, Tue Hvass Petersen, Karen Busted Larsen, Karine Madsen, Kasper Winther Andersen, Irina Akopian, Kristoffer Hougaard Madsen, Christian Pilebæk Hansen, Ingrid Poulsen, Lars Peter Kammersgaard, Hartwig Roman Siebner
INTRODUCTION: Traumatic brain injury (TBI) is considered one of the most pervasive causes of disability in people under the age of 45. TBI often results in disorders of consciousness, and clinical assessment of the state of consciousness in these patients is challenging due to the lack of behavioural responsiveness. Functional neuroimaging offers a means to assess these patients without the need for behavioural signs, indicating that brain connectivity plays a major role in consciousness emergence and maintenance...
June 14, 2017: BMJ Open
Xia Lu, Xinjie Bao, Jiantao Li, Guanghao Zhang, Jian Guan, Yunzhou Gao, Peilin Wu, Zhaohui Zhu, Xiaolin Huo, Renzhi Wang
Transcranial magnetic stimulation (TMS) is a method of noninvasive brain stimulation that causes neuromodulation by activating neurons or changing excitability in a certain brain area. Considering the known effects of TMS and the pathophysiology of traumatic brain injury (TBI), TMS was proposed to have potential for treating this condition. Moderate TBI was induced in adult male Sprague Dawley rats using Feeney's weight-dropping method. Injured rats were divided into a TMS group and a control group. Repetitive TMS (rTMS) was administered to rats in the TMS group from post-TBI day 2...
May 2017: Experimental and Therapeutic Medicine
Sean K Meehan, Jasmine L Mirdamadi, Douglas N Martini, Steven P Broglio
Adolescence and early adulthood is a critical period for neurophysiological development potentially characterized by an increased susceptibility to the long-term effects of traumatic brain injury. The current study investigated differences in motor cortical physiology and neuroplastic potential across a cohort of young adults with adolescent concussion history and those without. Transcranial magnetic stimulation (TMS) was used to assess motor evoked potential (MEP) amplitude, short-interval cortical inhibition (SICI) and intracortical facilitation (ICF) before and after intermittent theta burst stimulation (iTBS)...
2017: Frontiers in Human Neuroscience
Alia L Yasen, David R Howell, Li-Shan Chou, Angela M Pazzaglia, Anita D Christie
PURPOSE: To prospectively examine the association between intracortical inhibition and functional recovery following mild traumatic brain injury (mTBI). METHODS: Twenty individuals with mTBI and twenty matched control participants were assessed using transcranial magnetic stimulation (TMS), the Attentional Network Test (ANT), and gait analysis. Hierarchical linear modeling was used to longitudinally examine potential differences between groups and relationships in the pattern of recovery in cortical silent period (CSP) duration, cognitive reaction time, and single and dual-task walking speeds across 5 testing time points...
January 24, 2017: Medicine and Science in Sports and Exercise
Trevor A Seeger, Adam Kirton, Michael J Esser, Clare Gallagher, Jeff Dunn, Ephrem Zewdie, Omar Damji, Patrick Ciechanski, Karen M Barlow
INTRODUCTION: Mild traumatic brain injury (mTBI) outcomes are variable, and 10-15% may suffer from prolonged symptoms beyond 3 months that impair the child's return to normal activities. Neurophysiological mechanisms of mTBI are incompletely understood, particularly in children, but alterations in cortical excitability have been proposed to underlie post-concussion syndrome. Improved understanding is required to advance interventions and improve outcomes. OBJECTIVE/HYPOTHESIS: To determine if cortical excitability is altered in children with mTBI, and its association with clinical symptoms...
March 2017: Brain Stimulation
Jun Matsumoto-Miyazaki, Yoshitaka Asano, Shingo Yonezawa, Yuichi Nomura, Yuka Ikegame, Tatsuki Aki, Shunsuke Takenaka, Jun Shinoda
OBJECTIVE: To evaluate the immediate effect of acupuncture on cortico spinal tract (CST) activity in patients with chronic disorders of consciousness (DOC) after traumatic brain injury (TBI) by measuring motor-evoked potential (MEP) using transcranial magnetic stimulation (TMS). DESIGN: Changes in several variables in the acupuncture session were compared with those in the control session without acupuncture in the same patients. SETTING: Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Gifu, Japan...
November 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Skadi Wilke, Jonathan List, Ralf Mekle, Robert Lindenberg, Martin Bukowski, Stefanie Ott, Florian Schubert, Bernd Ittermann, Agnes Flöel
In patients in the chronic phase after recurrent mild traumatic brain injury (mTBI), alterations in gamma-aminobutyric acid (GABA) concentration and receptor activity have been reported, possibly mediating subtle but persistent cognitive deficits and increased rate of dementia in older age. We evaluated whether anodal transcranial direct current stimulation (atDCS) over the primary motor cortex reduces GABA concentration and GABAB receptor activity in patients with recurrent mTBI. Seventeen patients (mean age 25, two women) in the chronic phase after recurrent mTBI and 22 healthy control subjects (mean age 26, two women) were included...
January 15, 2017: Journal of Neurotrauma
Leila Chaieb, Andrea Antal, Florentin Masurat, Walter Paulus
Near-infrared light stimulation of the brain has been claimed to improve deficits caused by traumatic brain injury and stroke. Here, we exploit the effect of transcranial near-infrared stimulation (tNIRS) as a tool to modulate cortical excitability in the healthy human brain. tNIRS was applied at a wavelength of 810 nm for 10 min over the hand area of the primary motor cortex (M1). Both single-pulse and paired-pulse measures of transcranial magnetic stimulation (TMS) were used to assess levels of cortical excitability in the corticospinal pathway and intracortical circuits...
2015: Frontiers in Behavioral Neuroscience
Geneviève Lefebvre, Sara Tremblay, Hugo Théoret
PRIMARY OBJECTIVE: The present paper systematically reviews studies using transcranial magnetic stimulation (TMS) over the primary motor cortex (M1) to assess cortical excitability, intra-cortical inhibition/facilitation and synaptic plasticity following mild traumatic brain injury (mTBI). METHODS: Articles using TMS over M1 in patients with mTBI or sport-related concussion indexed in PubMed and published between 1998 and September 2014 were included in the present review...
2015: Brain Injury: [BI]
Stephen J Page, David A Cunningham, Ela Plow, Brittani Blazak
The goal of postacute neurorehabilitation is to maximize patient function, ideally by using surviving brain and central nervous system tissue when possible. However, the structures incorporated into neurorehabilitative approaches often differ from this target, which may explain why the efficacy of conventional clinical treatments targeting neurologic impairment varies widely. Noninvasive brain stimulation (eg, transcranial magnetic stimulation [TMS], transcranial direct current stimulation [tDCS]) offers the possibility of directly targeting brain structures to facilitate or inhibit their activity to steer neural plasticity in recovery and measure neuronal output and interactions for evaluating progress...
April 2015: Archives of Physical Medicine and Rehabilitation
Brendan P Major, Mark A Rogers, Alan J Pearce
Mild traumatic brain injury (mTBI) and sports concussion are a growing public health concern, with increasing demands for more rigorous methods to quantify changes in the brain post-injury. Electrophysiology, and in particular, transcranial magnetic stimulation (TMS), have been demonstrated to provide prognostic value in a range of neurological conditions; however, no review has quantified the efficacy of TMS in mTBI/concussion. In the present study, we present a systematic review and critical evaluation of the scientific literature from 1990 to 2014 that has used TMS to investigate corticomotor excitability responses at short-term (< 12 months), medium-term (1-5 years), and long-term (> 5 years) post-mTBI/concussion...
April 2015: Clinical and Experimental Pharmacology & Physiology
Shirley Fecteau, Maya Dickler, Raul Pelayo, Hatice Kumru, Monste Bernabeu, Eloy Opisso Salleras, José Maria Tormos, Alvaro Pascual-Leone
Studies indicate that motor functions in patients with traumatic brain injury (TBI) can be improved with action observation. It has been hypothesized that this clinical practice relies on modulation of motor cortical excitability elicited by passive action observation in patients with TBI, a phenomenon shown thus far only in normal controls. The purpose of this work was to test this hypothesis and characterize the modulation of motor cortex excitability during passive action observation in patients with subacute moderate to severe TBI...
July 2015: Neurorehabilitation and Neural Repair
Amy A Herrold, Sandra L Kletzel, Brett C Harton, R Andrew Chambers, Neil Jordan, Theresa Louise-Bender Pape
Alcohol use disorder (AUD), mild traumatic brain injury (mTBI), and posttraumatic stress disorder (PTSD) commonly co-occur (AUD + mTBI + PTSD). These conditions have overlapping symptoms which are, in part, reflective of overlapping neuropathology. These conditions become problematic because their co-occurrence can exacerbate symptoms. Therefore, treatments must be developed that are inclusive to all three conditions. Repetitive transcranial magnetic stimulation (rTMS) is non-invasive and may be an ideal treatment for co-occurring AUD + mTBI + PTSD...
October 1, 2014: Neural Regeneration Research
Marika Urbanski, Olivier A Coubard, Clémence Bourlon
Visual field defects (VFDs) are one of the most common consequences observed after brain injury, especially after a stroke in the posterior cerebral artery territory. Less frequently, tumors, traumatic brain injury, brain surgery or demyelination can also determine various visual disabilities, from a decrease in visual acuity to cerebral blindness. Visual field defects is a factor of bad functional prognosis as it compromises many daily life activities (e.g., obstacle avoidance, driving, and reading) and therefore the patient's quality of life...
2014: Frontiers in Integrative Neuroscience
Dylan M Nielson, Curtis A McKnight, Riddhi N Patel, Andrew J Kalnin, Walter J Mysiw
Transcranial magnetic stimulation has generated extensive interest within the traumatic brain injury (TBI) rehabilitation community, but little work has been done with repetitive protocols, which can produce prolonged changes in behavior. This is partly because of concerns about the safety of repetitive transcranial magnetic stimulation (rTMS) in subjects with TBI, particularly the risk of seizures. These risks can be minimized by careful selection of the rTMS protocol and exclusion criteria. In this article, we identify guidelines for safe use of rTMS in subjects with TBI based on a review of the literature and illustrate their application with a case study...
April 2015: Archives of Physical Medicine and Rehabilitation
Mark S George, Rema Raman, David M Benedek, Christopher G Pelic, Geoffrey G Grammer, Karen T Stokes, Matthew Schmidt, Chad Spiegel, Nancy Dealmeida, Kathryn L Beaver, Jeffrey J Borckardt, Xiaoying Sun, Sonia Jain, Murray B Stein
BACKGROUND: Suicide attempts and completed suicides are common, yet there are no proven acute medication or device treatments for treating a suicidal crisis. Repeated daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) for 4-6 weeks is a new FDA-approved treatment for acute depression. Some open-label rTMS studies have found rapid reductions in suicidality. DESIGN: This study tests whether a high dose of rTMS to suicidal inpatients is feasible and safe, and also whether this higher dosing might rapidly improve suicidal thinking...
May 2014: Brain Stimulation
Mauricio Fernando Villamar, Andrea Santos Portilla, Felipe Fregni, Ross Zafonte
OBJECTIVE: To review the use of noninvasive brain stimulation (NBS) as a therapeutic tool to enhance neuroplasticity following traumatic brain injury (TBI). MATERIALS AND METHODS: Based on a literature search, we describe the pathophysiological events following TBI and the rationale for the use of transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) in this setting. RESULTS: The pathophysiological mechanisms occurring after TBI vary across time and therefore require differential interventions...
July 2012: Neuromodulation: Journal of the International Neuromodulation Society
Mohan Krishnan, Nichole Smith, Jacobus Donders
The Tower of London - Drexel University, Second Edition (TOL(DX)) was investigated in order to determine the efficacy of using this instrument in evaluating the impact of traumatic brain injury on cognitive functioning in adults. Performance on the TOL(DX) was compared among 56 individuals with complicated mild to severe traumatic brain injury ("sTBI"), 68 individuals with uncomplicated, mild traumatic brain injury ("mTBI"), and 124 demographically matched, healthy controls. Both TBI groups performed worse than controls on TOL(DX) measures of executive time (ET) and number of moves used (TMS), but only patients with sTBI were more likely to be impaired on TMS (i...
2012: Clinical Neuropsychologist
Shahid Bashir, Marine Vernet, Woo-Kyoung Yoo, Ilan Mizrahi, Hugo Theoret, Alvaro Pascual-Leone
PURPOSE: Even after a mild traumatic brain injury (TBI) symptoms may be long lasting and never resolve completely. The neurophysiologic substrate for such lasting deficits remains unclear. There is a lack of objective measures of early brain abnormalities following mild TBI, which could shed light on the genesis of these lasting impairments. METHODS: Here we report findings in a previously healthy man tested 2 and 6 weeks after a well-documented concussion. Findings were compared with 12 control subjects...
2012: Restorative Neurology and Neuroscience
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