keyword
MENU ▼
Read by QxMD icon Read
search

nebivolol

keyword
https://www.readbyqxmd.com/read/27925253/fast-and-sensitive-analysis-of-beta-blockers-by-ultra-highperformance-liquid-chromatography-coupled-with-ultrahigh-resolution-tof-mass-spectrometry
#1
Jana Tomková, Peter Ondra, Eva Kocianová, Jan Václavík
This paper presents a method for the determination of acebutolol, betaxolol, bisoprolol, metoprolol, nebivolol and sotalol in human serum by liquid-liquid extraction (LLE) and ultra-high-performance liquid chromatography coupled with ultra-high-resolution TOF mass spectrometry (UHPLC-UHR-TOF MS). After liquid-liquid extraction, beta blockers were separated on a reverse phase analytical column Acclaim RS 120 (100 × 2.1 mm, 2.2 µm). The total run time was 6 min for each sample. Linearity, limit of detection (LOD), limit of quantification (LOQ), matrix effects, specificity, precision, accuracy, recovery and sample stability were evaluated...
December 7, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27862262/different-effects-of-selective-%C3%AE-1-adrenoceptor-antagonists-nebivolol-or-atenolol-in-acetaminophen-induced-heptatotoxicity-of-rats
#2
Remon R Rofaeil, Maha Yehia Kamel, Walaa Yehia Abdelzaher
Acetaminophen (APAP) overdose is a common cause of acute liver failure and beta blockers are commonly used drugs in clinical practice. This study aims to evaluate the effect of two different beta blockers agents as nebivolol and atenolol against APAP-induced hepatotoxicity. Male wistar rats were treated with APAP (2 g/kg/day, p.o.) to induce hepatotoxicity. Our results showed that nebivolol and atenolol reduced heart rate and blood pressure. Nebivolol (5 mg/kg /day, p.o.) for 14 days has a hepatoprotective effect shown by significant decrease in hepatic injury parameters (serum AST and ALT) with significant suppression of hepatic malondialdehyde (MDA) and nitric oxide (NO) which were elevated with APAP administration...
November 14, 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27850589/951-role-of-nebivolol-therapy-in-patients-with-severe-acute-respiratory-distress-syndrome
#3
Samir Hegazy, Tamer Helmy, Mohammed Salah
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27809882/comparative-effects-of-nebivolol-and-carvedilol-on-left-ventricular-diastolic-function-in-older-heart-failure-patients-with-preserved-ejection-fraction-study-protocol-for-a-randomized-controlled-trial
#4
Kyungil Park, Tae-Ho Park
BACKGROUND: Heart failure (HF) is a common and disabling condition in older people. Randomized clinical trials and meta-analyses have clearly demonstrated that the long-term use of β-Blockers improves the outcome of patients with HF. However, limited data are available on the treatment of older HF patients with preserved ejection fraction (EF). No study has specifically compared the relative effectiveness of carvedilol and nebivolol in treating HF in older patients with preserved EF...
November 3, 2016: Trials
https://www.readbyqxmd.com/read/27809345/bioequivalence-study-between-a-fixed-dose-single-pill-formulation-of-nebivolol-plus-hydrochlorothiazide-and-separate-formulations-in-healthy-subjects-using-high-performance-liquid-chromatography-coupled-to-tandem-mass-spectrometry
#5
Celso Francisco Pimentel Vespasiano, Tiago Luders Laurito, Renan Donomae Iwamoto, Ronilson Agnaldo Moreno, Gustavo D Mendes, Gilberto De Nucci
Systemic arterial hypertension is a major risk factor for cerebrovascular disease. Therefore, an adequate control of blood pressure is of enormous importance. One of the many fixed-dose single-pill antihypertensive formulations available on the market is the combination of nebivolol and hydrochlorothiazide. The objective of this study was to develop two distinct high performance liquid chromatography coupled to tandem mass spectrometry methods to simultaneously quantify nebivolol and hydrochlorothiazide in human plasma...
November 3, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27771847/multicenter-randomized-double-blind-comparison-of-nebivolol-plus-hctz-and-irbesartan-plus-hctz-in-the-treatment-of-isolated-systolic-hypertension-in-elderly-patients-results-of-the-nehis-study
#6
Guido Grassi, Gino Seravalle, Gianmaria Brambilla, Raffaella Dell'Oro, Fosca Quarti Trevano, Francesco Fici, Luc van Bortel, Giuseppe Mancia
INTRODUCTION: The present study was aimed at comparing the antihypertensive efficacy, tolerability, and side effects profile of nebivolol/hydrochlorothiazide (NH) vs irbesartan/hydrochlorothiazide (IH) combination in elderly patients with isolated systolic hypertension (ISH). METHODS: 124 ISH patients aged 69.1 ± 5.1 years (mean ± SD) were enrolled by 13 general practitioners in Netherlands and Belgium and randomized in a double-blind fashion to receive either NH (5/12...
October 22, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27754291/br-08-3-management-of-dyslipidemia-in-hypertension
#7
V V Muthusamy
Cardiovascular disease burden is increasing all over the world. The diagnosis of hypertension is considered when a person has persistently elevated BP (Systolic BP more than 140 mmHg and/or Diastolic BP more than 90 mmHg). Dyslipidemia denotes abnormal levels of lipids in the blood (Total Cholesterol >200 mg%, Low density lipoprotein (LDL) >100 mg%, Triglycerides (TGL) >150 mg% and High density lipoprotein (HDL) <40 mg in men and < 50 mg in women. Hypertension and Dyslipidemia constitute the important components of metabolic syndrome as per the definition of NCEP Guidelines-Adult Treatment Panel III (ATP III)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27728376/a-comparative-study-of-nebivolol-and-s-atenolol-on-blood-pressure-and-heart-rate-on-essential-hypertensive-patients
#8
P K Agrawal, Vikash Kumar, A Kumar, S Prasad
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27716772/the-beta-1-receptor-blocker-nebivolol-elicits-dilation-of-cerebral-arteries-by-reducing-smooth-muscle-ca2-i
#9
Peter Cseplo, Zoltan Vamos, Ivan Ivic, Orsolya Torok, Attila Toth, Akos Koller
RATIONALE: Nebivolol is known to have beta-1 blocker activity, but it was also suggested that it elicits relaxation of the peripheral arteries in part via release of nitric oxide (NO). However, the effect of nebivolol on the vasomotor tone of cerebral arteries is still unclear. OBJECTIVE: To assess the effects of nebivolol on the diameter of isolated rat basilar arteries (BA) in control, in the presence of inhibitors of vasomotor signaling pathways of know action and hemolysed blood...
2016: PloS One
https://www.readbyqxmd.com/read/27703551/protective-effects-of-vasodilatory-%C3%AE-eta-blockers-carvedilol-and-nebivolol-against-glycerol-model-of-rhabdomyolysis-induced-acute-renal-failure-in-rats
#10
Ahmed Atwa, Rehab Hegazy, Nermeen Shaffie, Neamat Yassin, Sanaa Kenawy
BACKGROUND: Rhabdomyolysis (RM)-induced acute renal failure (ARF) accounts for about 10-40% of all cases of ARF. AIM: The present study investigated the possible protective effect of two nitric oxides (NO)-releasing third generation β-blockers, carvedilol (Carv) and nebivolol (Nebi), against RM-mimicking glycerol (Gly)-induced ARF in rats. MATERIAL AND METHODS: After 24 h dehydration, rats received a single dose of 50% Gly (8 ml/kg, im). They were treated with vehicle, Carv (2...
September 15, 2016: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27701056/nebivolol-suppresses-asymmetric-dimethylarginine-and-attenuates-cyclosporine-induced-nephrotoxicity-and-endothelial-dysfunction-in-rats
#11
Wafaa A Hewedy, Dalia K Mostafa
BACKGROUND: Cyclosporine A (CsA)-induced nephrotoxicity is a challenging problem complicating its chronic use in a large array of autoimmune diseases, as well as in organ transplantation. A considerable body of evidence points to the involvement of nitric oxide (NO) and its endogenous synthesis inhibitor, asymmetric dimethylarginine (ADMA), in CsA-induced renal and cardiovascular adverse effects. In this study, the potential of the third generation β-blocker, nebivolol, to modify the NO/ADMA system is hypothesized to play a role in protection against CsA-induced renal injury and endothelial dysfunction...
August 31, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27686325/nebivolol-ameliorates-cardiac-nlrp3-inflammasome-activation-in-a-juvenile-adolescent-animal-model-of-diet-induced-obesity
#12
Qihai Xie, Tong Wei, Chenglin Huang, Penghao Liu, Mengwei Sun, Weili Shen, Pingjin Gao
NLRP3 is involved in obesity-induced cardiac remodeling and dysfunction. In this study, we evaluated whether the cardiac protective effects of nebivolol relied on attenuating NLRP3 activation in a juvenile-adolescent animal model of diet-induced obesity. Weaning male Sprague-Dawley rats were fed with either a standard chow diet (ND) or a high-fat diet (HFD) for 8 weeks. The obese rats were subsequently subdivided into three groups: 1) HFD control group; 2) HFD with low-dose nebivolol (5 mg/kg/d); 3) HFD with high-dose nebivolol (10 mg/kg/d)...
September 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27677146/the-effects-of-nebivolol-valsartan-single-pill-combinations-in-reducing-blood-pressure-in-patients-with-stage-i-or-ii-hypertension
#13
M A Weber, G L Bakris, W B White, L Xie, D Bharucha, M Patel
No abstract text is available yet for this article.
July 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/27677141/additivity-of-nebivolol-valsartan-single-pill-combination-versus-other-single-pill-combinations-for-hypertension
#14
J Ishak, M Rael, H Punzi, A Gradman, M Patel, S Ali, W Ferguson, J Neutel
No abstract text is available yet for this article.
July 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/27668163/rhabdomyolysis-in-a-patient-taking-nebivolol
#15
Ye Jin Kim, Hae Ri Kim, Hong Jae Jeon, Hyun Jun Ju, Sarah Chung, Dae Eun Choi, Kang Wook Lee, Ki Ryang Na
β Blockers such as propranolol and labetalol are known to induce toxic myopathy because of their partial β2 adrenoceptor agonistic effect. Nebivolol has the highest β1 receptor affinity among β blockers, and it has never been reported to induce rhabdomyolysis until now. We report a patient who developed rhabdomyolysis after changing medication to nebivolol. A 75-year-old woman was admitted to our hospital because of generalized weakness originating 2 weeks before visiting. Approximately 1 month before her admission, her medication was changed from carvedilol 12...
September 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27663278/effect-of-nebivolol-treatment-during-pregnancy-on-the-intrauterine-fetal-growth-mortality-and-pup-postnatal-development-in-the-l-name-induced-hypertensive-rats
#16
Kassem Altoama, Mohamed Yassine Mallem, Chantal Thorin, Eric Betti, Jean-Claude Desfontis
The present study was carried out to evaluate the effect of nebivolol vs. bisoprolol treatment on the intrauterine fetal growth, mortality and postnatal development in N(ω)-Nitro-l-arginine methyl ester hydrochloride (l-NAME)-induced hypertensive rats. Hypertension was induced in normotensive pregnant Wistar rats by daily administration of l-NAME (100mg/kg/day, in the drinking water) for the period of pregnancy. After 9 days of l-NAME treatment, rats with systolic and diastolic blood pressure (SBP and DBP) more than 140/90mmHg were considered hypertensive...
September 20, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27643289/br-08-3-management-of-dyslipidemia-in-hypertension
#17
V V Muthusamy
Cardiovascular disease burden is increasing all over the world. The diagnosis of hypertension is considered when a person has persistently elevated BP (Systolic BP more than 140 mmHg and/or Diastolic BP more than 90 mmHg). Dyslipidemia denotes abnormal levels of lipids in the blood (Total Cholesterol >200 mg%, Low density lipoprotein (LDL) >100 mg%, Triglycerides (TGL) >150 mg% and High density lipoprotein (HDL) <40 mg in men and < 50 mg in women. Hypertension and Dyslipidemia constitute the important components of metabolic syndrome as per the definition of NCEP Guidelines-Adult Treatment Panel III (ATP III)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27623776/nebivolol-suppresses-cardiac-ryanodine-receptor-mediated-spontaneous-ca2-release-and-catecholaminergic-polymorphic-ventricular-tachycardia
#18
Zhen Tan, Zhichao Xiao, Jinhong Wei, Jingqun Zhang, Qiang Zhou, Chris D Smith, Alma Nani, Guogen Wu, Long-Sheng Song, Thomas G Back, Michael Fill, S R Wayne Wayne Chen
Beta-blockers are a standard treatment for heart failure and cardiac arrhythmias. There are about 30 commonly used beta-blockers representing a diverse class of drugs with different receptor affinities and pleiotropic properties. We reported that among 14 beta-blockers tested previously, only carvedilol effectively suppressed cardiac ryanodine receptor (RyR2) mediated spontaneous Ca(2+) waves during store Ca(2+) overload, also known as store-overload induced Ca(2+) release (SOICR). Given the critical role of SOICR in arrhythmogenesis, it is of importance to determine whether there are other beta-blockers that suppress SOICR...
September 13, 2016: Biochemical Journal
https://www.readbyqxmd.com/read/27620808/effects-of-long-term-active-immunization-with-the-second-extracellular-loop-of-human-%C3%AE-1-or-%C3%AE-3-adrenoceptors-in-thoracic-aorta-and-mesenteric-arteries-in-lewis-rats
#19
E Montaudon, L Dubreil, V Lalanne, B Jagu, G Toumaniantz, C Thorin, D Henrion, J-C Desfontis, L Martignat, M Y Mallem
OBJECTIVE: To evaluate whether active immunization producing β1- or β3-antibodies (β1-ABs and β3-ABs) detected in sera of patients with dilated cardiomyopathies has deleterious effects on vascular reactivity in Lewis rats thoracic aorta (TA) and small mesenteric arteries (SMA). DESIGN AND METHOD: Lewis rats were immunized for 6months with peptidic sequences corresponding to the second extracellular loop of β1- and β3-adrenoceptors (ARs). During the immunization, systolic blood pressure (SBP) was monitored using the tail cuff method...
September 9, 2016: Vascular Pharmacology
https://www.readbyqxmd.com/read/27598048/clinical-relevance-of-central-blood-pressure-a-critical-review
#20
Michael Kostapanos, Carmel M McEniery, Ian B Wilkinson
Vital organs are exposed to the central rather than the brachial blood pressure. To date, central blood pressure can be assessed noninvasively through the use of several devices. In this review, we critically discuss the clinical relevance of central blood pressure assessment. Considerable evidence suggests that central blood pressure is a better predictor of end-organ damage than brachial blood pressure. However, there is still uncertainty concerning the value of central pressure for predicting cardiovascular outcomes, as the existing studies are underpowered to address this issue...
September 6, 2016: VASA. Zeitschrift Für Gefässkrankheiten
keyword
keyword
39964
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"