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https://www.readbyqxmd.com/read/29913243/spinal-inhibition-of-p2xr-or-p38-signaling-disrupts-hyperalgesic-priming-in-male-but-not-female-mice
#1
Candler Paige, Gayathri Batchalli Maruthy, Galo Mejia, Gregory Dussor, Theodore Price
Recent studies have demonstrated sexual dimorphisms in the mechanisms contributing to the development of chronic pain. Here we tested the hypothesis that microglia might preferentially regulate hyperalgesic priming in male mice. We based this hypothesis on evidence that microglia preferentially contribute to neuropathic pain in male mice via ionotropic purinergic receptor (P2XR) or p38 mitogen activated protein kinase (p38) signaling. Mice given a single priming injection of the soluble human interleukin-6 receptor (IL-6r) and then a second injection of prostaglandin E2 (PGE2 ), which unmasks hyperalgesic priming, show a significant increase in levels of activated microglia at 3h following the PGE2 injection in both male and female mice...
June 15, 2018: Neuroscience
https://www.readbyqxmd.com/read/29912934/multigenerational-effects-of-bisphenol-a-or-ethinyl-estradiol-exposure-on-f2-california-mice-peromyscus-californicus-pup-vocalizations
#2
Sarah A Johnson, Michelle J Farrington, Claire R Murphy, Paul D Caldo, Leif A McAllister, Sarabjit Kaur, Catherine Chun, Madison T Ortega, Brittney L Marshall, Frauke Hoffmann, Mark R Ellersieck, A Katrin Schenk, Cheryl S Rosenfeld
Rodent pups use vocalizations to communicate with one or both parents in biparental species, such as California mice (Peromyscus californicus). Previous studies have shown California mice developmentally exposed to endocrine disrupting chemicals, bisphenol A (BPA) or ethinyl estradiol (EE), demonstrate later compromised parental behaviors. Reductions in F1 parental behaviors might also be due to decreased emissions of F2 pup vocalizations. Thus, vocalizations of F2 male and female California mice pups born to F1 parents developmentally exposed to BPA, EE, or controls were examined...
2018: PloS One
https://www.readbyqxmd.com/read/29911877/developing-a-direct-rating-behavior-scale-for-depression-in-middle-school-students
#3
Stephen P Kilgus, Michael P Van Wie, James S Sinclair, T Chris Riley-Tillman, Keith C Herman
Research has supported the applied use of Direct Behavior Rating Single-Item Scale (DBR-SIS) targets of "academic engagement" and "disruptive behavior" for a range of purposes, including universal screening and progress monitoring. Though useful in evaluating social behavior and externalizing problems, these targets have limited utility in evaluating emotional behavior and internalizing problems. Thus, the primary purpose of this study was to support the initial development and validation of a novel DBR-SIS target of "unhappy," which was intended to tap into the specific construct of depression...
June 18, 2018: School Psychology Quarterly
https://www.readbyqxmd.com/read/29910711/functional-consequences-of-the-postnatal-switch-from-neonatal-to-mutant-adult-glycine-receptor-%C3%AE-1-subunits-in-the-shaky-mouse-model-of-startle-disease
#4
Natascha Schaefer, Fang Zheng, Johannes van Brederode, Alexandra Berger, Sophie Leacock, Hiromi Hirata, Christopher J Paige, Robert J Harvey, Christian Alzheimer, Carmen Villmann
Mutations in GlyR α1 or β subunit genes in humans and rodents lead to severe startle disease characterized by rigidity, massive stiffness and excessive startle responses upon unexpected tactile or acoustic stimuli. The recently characterized startle disease mouse mutant shaky carries a missense mutation (Q177K) in the β8-β9 loop within the large extracellular N-terminal domain of the GlyR α1 subunit. This results in a disrupted hydrogen bond network around K177 and faster GlyR decay times. Symptoms in mice start at postnatal day 14 and increase until premature death of homozygous shaky mice around 4-6 weeks after birth...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29910689/health-risks-associated-with-genetic-alterations-in-internal-clock-system-by-external-factors
#5
REVIEW
Suliman Khan, Ghulam Nabi, Lunguang Yao, Rabeea Siddique, Wasim Sajjad, Sunjeet Kumar, Pengfei Duan, Hongwei Hou
The circadian system maintains the main aspects of physiological and behavioral processes. Both circadian rhythm and sleep impact an organism's health through interaction with environmental factors. Variations in external factors influence the functionality of clock genes and disrupt 24-hour rhythmic cycle. The disrupted circadian rhythm and disregulated sleep affect an organism's health, thereby causing several disorders including cancer, depression and cardiac disorders. Considering the role of clock genes and environmental factors, extensive investigation is required focusing on pathways involved in development of life-threatening disorders...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29909821/design-strategies-to-improve-healthcare-worker-safety-in-biocontainment-units-learning-from-ebola-preparedness
#6
Jennifer R DuBose, Zorana Matić, Maria Fernanda Wong Sala, Joel M Mumma, Colleen S Kraft, Lisa M Casanova, Kimberly Erukunuakpor, Francis T Durso, Victoria L Walsh, Puja Shah, Craig M Zimring, Jesse T Jacob
OBJECTIVE: To identify ways that the built environment may support or disrupt safe doffing of personal protective equipment (PPE) in biocontainment units (BCU). DESIGN: We observed interactions between healthcare workers (HCWs) and the built environment during 41 simulated PPE donning and doffing exercises. SETTING: The BCUs of 4 Ebola treatment facilities and 1 high-fidelity BCU mockup.ParticipantsA total of 64 HCWs (41 doffing HCWs and 15 trained observers) participated in this study...
June 18, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29909300/parsing-cyclothymic-disorder-and-other-specified-bipolar-spectrum-disorders-in-youth
#7
Anna Van Meter, Benjamin I Goldstein, Tina R Goldstein, Shirley Yen, Heather Hower, Michael Strober, John A Merranko, Mary Kay Gill, Rasim S Diler, David Axelson, Neal D Ryan, Martin B Keller, Boris Birmaher
OBJECTIVE: Most studies of pediatric bipolar disorder (BP) combine youth who have manic symptoms, but do not meet criteria for BP I/II, into one "not otherwise specified" (NOS) group. Consequently, little is known about how youth with cyclothymic disorder (CycD) differ from youth with BP NOS. The objective of this study was to determine whether youth with a research diagnosis of CycD (RDCyc) differ from youth with operationalized BP NOS. METHOD: Participants from the Course and Outcome of Bipolar Youth study were evaluated to determine whether they met RDCyc criteria...
June 7, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29909181/stress-related-deficits-of-older-adults-spatial-working-memory-an-eeg-investigation-of-occipital-alpha-and-frontal-midline-theta-activities
#8
Amanda C Marshall, Nicholas Cooper, Livia Rosu, Steffan Kennett
Studies highlight cumulative life stress as a significant predictor of accelerated cognitive aging. This study paired electrophysiological with behavioral measures to explore how cumulative stress affects attentional and maintenance processes underpinning working memory retention. We collected electroencephalographic recordings from 60 individuals (30 older, 30 younger) reporting high or low levels of cumulative stress during the performance of a spatial Sternberg task. We measured mid-occipital alpha (8-12 Hz) and frontal-midline theta (4-6 Hz) as indicators of attentional and maintenance processes...
May 29, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29908235/the-effect-of-antibiotics-on-social-aversion-following-early-life-inflammation
#9
Amanda C Kentner, Urma Khan, M MacRae, Scot E Dowd, Siyang Yan
Epidemiological evidence suggests that exposure to infection during early development increases the risk for neurodevelopmental disorders associated with symptoms such as a decreased desire to engage in social interactions. This disruption in social behavior can be modelled in animals by administering bacterial mimetics such as liposaccharide (LPS). However, when evaluating social interactions in the laboratory, attention is rarely directed on the reciprocal relationship as a whole, which is important as peers may drive social withdrawal...
June 13, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29907878/ketamine-administration-during-a-critical-period-after-forced-ethanol-abstinence-inhibits-the-development-of-time-dependent-affective-disturbances
#10
Oliver Vranjkovic, Garrett Winkler, Danny G Winder
Forced abstinence from chronic two bottle-choice ethanol drinking produces the development of negative affective states in female C57BL/6J mice. We previously reported that this disrupted behavior is acutely reversed by administration of ketamine 30 min-prior to testing. Here we assessed whether ketamine can be used as an inoculant against the development of abstinence- dependent affective disturbances. In parallel, we examined the impact of ketamine administration on long-term potentiation (LTP) in the bed nucleus of the stria terminalis (BNST), a region implicated in affective disturbances...
May 24, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29907639/t-type-calcium-channels-in-the-orbitofrontal-cortex-mediate-sensory-integration-as-measured-using-a-spontaneous-oddity-task-in-rats
#11
Wendie N Marks, Madeline E Parker, Nadine K Zabder, Quentin Greba, Terrance P Snutch, John G Howland
The roles of low-voltage-activated (T-type) calcium channels in brain diseases have been studied extensively. Less is known regarding the involvement of T-type channels in cognition and behavior. Sensory integration (SI) is a cognitive process whereby the brain uses unimodal or multimodal sensory features to create a comprehensive representation of the environment. The multisensory object oddity (MSO) task assesses SI using combinations of sensory features of objects, either in the same or different sensory modalities...
July 2018: Learning & Memory
https://www.readbyqxmd.com/read/29903616/mechanisms-of-vagal-plasticity-influencing-feeding-behavior
#12
REVIEW
Guillaume de Lartigue, Chelsea Xu
Sensory neurons of the vagus nerve receive many different peripheral signals that can change rapidly and frequently throughout the day. The ability of these neurons to convey the vast array of nuanced information to the brain requires neuronal adaptability. In this review we discuss evidence for neural plasticity in vagal afferent neurons as a mechanism for conveying nuanced information to the brain important for the control of feeding behavior. We provide evidence that synaptic plasticity, changes in membrane conductance, and neuropeptide specification are mechanisms that allow flexibility in response to metabolic cues that can be disrupted by chronic intake of energy dense diets...
August 15, 2018: Brain Research
https://www.readbyqxmd.com/read/29902773/a-biophysical-insight-into-the-formation-of-aggregates-upon-trifluoroethanol-induced-structural-and-conformational-changes-in-garlic-cystatin
#13
Mohd Faizan Siddiqui, Bilqees Bano
Intrinsic and extrinsic factors are responsible for the transition of soluble proteins into aggregated form. Trifluoroethanol is among such potent extrinsic factor which facilitates the formation of aggregated structure. It disrupts the interactive forces and destabilizes the native structure of the protein. The present study investigates the effect of trifluoroethanol (TFE) on garlic cystatin. Garlic cystatin was incubated with increasing concentration of TFE (0-90% v/v) for 4 h. Incubation of GPC with TFE induces structural changes thereby resulting in the formation of aggregates...
June 6, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29902739/responding-to-disruptive-behaviors-in-nursing-a-longitudinal-quasi-experimental-investigation-of-training-for-nursing-students
#14
Ericka Sanner-Stiehr
OBJECTIVES: The objective of this study was to determine the impact of a cognitive rehearsal intervention on nursing students' self-efficacy to respond effectively to disruptive behaviors. DESIGN: This quantitative study was part of a longitudinal, quasi-experimental program of research. SETTING: Interventions were conducted on site at facilities provided by participating pre-licensure nursing programs. PARTICIPANTS: A total of 129 nursing students enrolled in their final academic year in three traditional format, pre-licensure nursing programs in the Midwestern United States were recruited to participate in this study...
June 5, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29901645/minor-physical-anomalies-in-adolescents-at-risk-for-substance-use-and-early-sex
#15
Meng-Che Tsai, Chih-Ting Lee, I-Ning Tsai, Shu-Ting Gan, Yi-Lin Liang, Sheng-Hsiang Lin
Minor physical anomalies (MPAs) are associated with disruptions of fetal development. We propose that the same genetic compositions that contribute to the presence of MPAs, also predispose individuals to health-compromising behaviors, thus considering MPAs as particular endophenotypes.We developed a screening questionnaire for problematic conduct, substance abuse, and early sexual practice. A total of 108 adolescents (55 males, 50.9%) aged 11 to 19 years were recruited and further divided into case and control groups according to their answers to the questions of health behaviors mentioned above...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29898698/validity-and-reliability-of-the-kiddie-schedule-for-affective-disorders-and-schizophrenia-present-and-lifetime-version-dsm-5-k-sads-pl-5-spanish-version
#16
Francisco R de la Peña, Lino R Villavicencio, Juan D Palacio, Fernando J Félix, Marcela Larraguibel, Laura Viola, Silvia Ortiz, Marcos Rosetti, Andrea Abadi, Cecilia Montiel, Pablo A Mayer, Sofía Fernández, Aurora Jaimes, Miriam Feria, Liz Sosa, Andrés Rodríguez, Patricia Zavaleta, Daniela Uribe, Frinne Galicia, Diana Botero, Santiago Estrada, Arturo F Berber, Macarena Pi-Davanzo, Consuelo Aldunate, Gabriela Gómez, Ivannah Campodónico, Paula Tripicchio, Ignacio Gath, Manuel Hernández, Lino Palacios, Rosa E Ulloa
BACKGROUND: There are various language adaptations of the Schedule for Affective Disorders and Schizophrenia for School Age Children Present and Lifetime Version (K-SADS-PL). In order to comply with the changes in DSM classification, the Spanish edition of the interview was in need of update and evaluation. METHODS: K-SADS-PL was adapted to correspond to DSM-5 categories. All clinicians received training, and a 90% agreement was reached. Patients and their parents or guardians were interviewed and videotaped, and the videos were exchanged between raters...
June 14, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29898210/metabolic-effects-of-antipsychotics-on-adiposity-and-insulin-sensitivity-in-youths-a-randomized-clinical-trial
#17
Ginger E Nicol, Michael D Yingling, Karen S Flavin, Julia A Schweiger, Bruce W Patterson, Kenneth B Schechtman, John W Newcomer
Importance: Antipsychotic medications are commonly used to treat nonpsychotic disruptive behavioral disorders in youths. Objective: To characterize the metabolic effects of first exposure to antipsychotics in youths using criterion standard assessments of body composition and insulin sensitivity. Design, Setting, and Participants: This randomized clinical trial recruited antipsychotic-naive youths aged 6 to 18 years in the St Louis, Missouri, metropolitan area who were diagnosed with 1 or more psychiatric disorders and clinically significant aggression and in whom antipsychotic treatment was considered...
June 13, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29897486/a-clear-difference-emerges-in-hormone-patterns-following-a-standard-midday-meal-in-young-women-who-regularly-eat-or-skip-breakfast
#18
Shavawn M Forester, Adrianne M Widaman, Sridevi Krishnan, Megan G Witbracht, William F Horn, Kevin D Laugero, Nancy L Keim
Background: Multiple hormones are involved in the regulation of food intake and glucose metabolism. Past intervention studies showed a benefit of eating breakfast on satiety, but this was possibly confounded by the disruption of habitual meal patterns. Objective: The objective of this study was to compare hormonal responses, including insulin, leptin, glucagon-like peptide-1, ghrelin, peptide YY (PYY3-36), and cholecystokinin (CCK), between habitual breakfast eaters (Br-Es) and habitual skippers (Br-Ss) to a standard midday meal...
April 20, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29897446/the-influence-of-visual-vestibular-and-hindlimb-proprioceptive-ablations-on-landing-preparation-in-cane-toads
#19
S M Cox, L J Ekstrom, G B Gillis
Coordinated landing from a jump requires preparation, which must include appropriate positioning and configuration of the landing limbs and body to be successful. While well studied in mammals, our lab has been using the cane toad (Rhinella marinus) as a model for understanding the biomechanics of controlled landing in anurans, animals that use jumping or bounding as their dominant mode of locomotion. In this paper, we report new results from experiments designed to explore how different modes of sensory feedback contribute to previously identified features of coordinated landing in toads...
June 12, 2018: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/29897332/orbital-frontal-cortex-updates-state-induced-value-change-for-decision-making
#20
Emily T Baltz, Ege A Yalcinbas, Rafael Renteria, Christina M Gremel
Recent hypotheses have posited that orbital frontal cortex (OFC) is important for using inferred consequences to guide behavior. Less clear is OFC's contribution to goal-directed or model-based behavior, where the decision to act is controlled by previous experience with the consequence or outcome. Investigating OFC's role in learning about changed outcomes separate from decision-making is not trivial and often the two are confounded. Here we adapted an incentive learning task to mice, where we investigated processes controlling experience-based outcome updating independent from inferred action control...
June 13, 2018: ELife
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