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https://www.readbyqxmd.com/read/29352514/an-integrative-review-exploring-the-physical-and-psychological-harm-inherent-in-using-restraint-in-mental-health-inpatient-settings
#1
Pauline Cusack, Frank Patrick Cusack, Sue McAndrew, Mick McKeown, Joy Duxbury
In Western society, policy and legislation seeks to minimize restrictive interventions, including physical restraint; yet research suggests the use of such practices continues to raise concerns. Whilst international agreement has sought to define physical restraint, diversity in the way in which countries use restraint remains disparate. Research to date has reported on statistics regarding restraint, how and why it is used, and staff and service user perspectives about its use. However, there is limited evidence directly exploring the physical and psychological harm restraint may cause to people being cared for within mental health inpatient settings...
January 19, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29348807/discovery-of-spiro-oxazolidinediones-as-selective-orally-bioavailable-inhibitors-of-p300-cbp-histone-acetyltransferases
#2
Michael R Michaelides, Arthur Kluge, Michael Patane, John H Van Drie, Ce Wang, T Matthew Hansen, Roberto M Risi, Robert Mantei, Carmen Hertel, Kannan Karukurichi, Alexandre Nesterov, David McElligott, Peter de Vries, J William Langston, Philip A Cole, Ronen Marmorstein, Hong Liu, Loren Lasko, Kenneth D Bromberg, Albert Lai, Edward A Kesicki
p300 and its paralog CBP can acetylate histones and other proteins and have been implicated in a number of diseases characterized by aberrant gene activation, such as cancer. A novel, highly selective, orally bioavailable histone acetyltransferase (HAT) domain inhibitor has been identified through virtual ligand screening and subsequent optimization of a unique hydantoin screening hit. Conformational restraint in the form of a spirocyclization followed by substitution with a urea led to a significant improvement in potency...
January 11, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29348729/panax-ginseng-exerts-antidepressant-like-effects-by-suppressing-neuroinflammatory-response-and-upregulating-nuclear-factor-erythroid-2-related-factor-2-signaling-in-the-amygdala
#3
Jong Hee Choi, Min Jung Lee, Minhee Jang, Hak-Jae Kim, Sanghyun Lee, Sang Won Lee, Young Ock Kim, Ik-Hyun Cho
Background: Depression is one of the most commonly diagnosed neuropsychiatric diseases, but the underlying mechanism and medicine are not well-known. Although Panax ginseng has been reported to exert protective effects in various neurological studies, little information is available regarding its antidepressant effects. Methods: Here, we examined the antidepressant effect and underlying mechanism of P. ginseng extract (PGE) in a chronic restraint stress (CRS)-induced depression model in mice...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29348467/efficacy-of-mek-inhibition-in-a-k-ras-driven-cholangiocarcinoma-preclinical-model
#4
Mingjie Dong, Xianqiong Liu, Katja Evert, Kirsten Utpatel, Michele Peters, Shanshan Zhang, Zhong Xu, Li Che, Antonio Cigliano, Silvia Ribback, Frank Dombrowski, Antonio Cossu, John Gordan, Diego F Calvisi, Matthias Evert, Yan Liu, Xin Chen
Intrahepatic cholangiocarcinoma (iCCA) is a deadly malignancy with limited treatment options. Gain-of-function mutations in K-Ras is a very frequent alteration, occurring in ~15 to 25% of human iCCA patients. Here, we established a new iCCA model by expressing activated forms of Notch1 (NICD) and K-Ras (K-RasV12D) in the mouse liver (K-Ras/NICD mice). Furthermore, we investigated the therapeutic potential of MEK inhibitors in vitro and in vivo using human CCA cell lines and K-Ras/NICD mice, respectively. Treatment with U0126, PD901, and Selumetinib MEK inhibitors triggered growth restraint in all CCA cell lines tested, with the most pronounced growth suppressive effects being observed in K-Ras mutant cells...
January 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29346751/the-brain-compass-a-perspective-on-how-self-motion-updates-the-head-direction-cell-attractor
#5
REVIEW
Jean Laurens, Dora E Angelaki
Head direction cells form an internal compass signaling head azimuth orientation even without visual landmarks. This property is generated by a neuronal ring attractor that is updated using rotation velocity cues. The properties and origin of this velocity drive remain, however, unknown. We propose a quantitative framework whereby this drive represents a multisensory self-motion estimate computed through an internal model that uses sensory prediction errors of vestibular, visual, and somatosensory cues to improve on-line motor drive...
January 17, 2018: Neuron
https://www.readbyqxmd.com/read/29341884/acute-stress-persistently-alters-locus-coeruleus-function-and-anxiety-like-behavior-in-adolescent-rats
#6
Olga Borodovitsyna, Matthew D Flamini, Daniel J Chandler
Stress is a physiological state characterized by altered neuroendocrine signaling, behavioral arousal, and anxiety. Chronic or traumatic stress may predispose individuals for multiple somatic and psychiatric illnesses. The locus coeruleus (LC) is a major node in the stress response that integrates input from multiple stress responsive neural circuits and releases norepinephrine throughout the central nervous system to promote vigilance and anxiety. Many mood disorders associated with prior stress are characterized by chronically altered noradrenergic signaling, yet the long-term impact of an acute stressor on LC function is not clear...
January 13, 2018: Neuroscience
https://www.readbyqxmd.com/read/29341236/induced-earthquakes-from-long-term-gas-extraction-in-groningen-the-netherlands-statistical-analysis-and-prognosis-for-acceptable-risk-regulation
#7
Charles Vlek
Recently, growing earthquake activity in the northeastern Netherlands has aroused considerable concern among the 600,000 provincial inhabitants. There, at 3 km deep, the rich Groningen gas field extends over 900 km2 and still contains about 600 of the original 2,800 billion cubic meters (bcm). Particularly after 2001, earthquakes have increased in number, magnitude (M, on the logarithmic Richter scale), and damage to numerous buildings. The man-made nature of extraction-induced earthquakes challenges static notions of risk, complicates formal risk assessment, and questions familiar conceptions of acceptable risk...
January 16, 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29340298/efficacy-and-safety-of-sedation-during-endoscopic-submucosal-dissection-of-gastric-cancers-using-a-comparative-trial-of-propofol-versus-midazolam
#8
Hitomi Kikuchi, Takuto Hikichi, Ko Watanabe, Jun Nakamura, Tadayuki Takagi, Rei Suzuki, Mitsuru Sugimoto, Yuichi Waragai, Naoki Konno, Hiroyuki Asama, Mika Takasumi, Yuki Sato, Katsutoshi Obara, Hiromasa Ohira
Background and study aims : Proper sedation is necessary for the safe and satisfactory completion of endoscopic submucosal dissection (ESD) for early gastric cancer. This study was conducted as a comparative trial of efficacy and safety, comparing propofol-based sedation and midazolam-based sedation during ESD of early gastric cancer patients. Patients and methods : This study examined 64 lesions in 58 patients treated using ESD with midazolam plus pentazocine between July 2013 and January 2014 (group M) and 237 lesions in 216 patients treated by ESD using propofol plus pentazocine between February 2014 and December 2015 (group P)...
January 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29337463/-virtual-reality-a-tool-that-can-be-used-in-outpatient-diabetes-services
#9
Sébastien Miserez, Léonie Chinet, Alberto Guardia, Fabienne Matthys, Isabelle Hagon-Traub
Health-related emerging technologies are growing fast. The use of virtual reality in diabetes outpatient care still remains unprecedented, notably in Switzerland. Thus, the Programme cantonal Diabète led a pilot study to assess the feasibility of an immersive application in such an outpatient setting. Results emphasize that this device is practicable and useful in diabetes care. Patients and their relatives overall appreciate the game, each of them for specific reasons: playful quality, opportunity to « learn differently » or to exchange about the subjective experience...
January 10, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29335153/-the-sitting-position-during-peripheral-venipunctures-in-young-children-a-practice-to-develop
#10
REVIEW
Anne Dario-Meyer, Sylvie Sangare, Anne Dumas Laussinotte
The children's nurse has several missions including that of caring for the child in a holistic approach, ensuring their physical safety and psychological security. When performing peripheral venipunctures in young children, caregivers must implement strategies to relieve pain and prevent psychological traumas which may generate stress for subsequent care procedures. In a paediatric unit, their observations and analysis have improved children's experience of this invasive procedure, with a need for less restraint...
January 2018: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/29335089/associations-between-clinical-indicators-of-quality-and-aged-care-residents
#11
Yun-Hee Jeon, Anne-Nicole Casey, Kha Vo, Kris Rogers, Belinda Poole, Judith Fethney
Objectives To ascertain Australian multistate prevalence and incidence of five commonly collected clinical indicators of aged-care home quality and to measure associations between these clinical indicators and levels of care needs and consumer and staff satisfaction.Methods A retrospective analysis of national audit data collected from 426 facilities between 2015 and 2016 was performed. Regression models were used to examine associations between five clinical indicators (falls, pressure injury, physical restraint, unplanned weight loss and polypharmacy) and level of care needs measured by the Aged Care Funding Instrument (ACFI) and consumer and care staff survey responses...
January 16, 2018: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29331659/mindfulness-related-differences-in-neural-response-to-own-infant-negative-versus-positive-emotion-contexts
#12
Heidemarie K Laurent, Dorianne Wright, Megan Finnegan
Mindfulness is thought to promote well-being by shaping the way people respond to challenging social-emotional situations. Current understanding of how this occurs at the neural level is based on studies of response to decontextualized emotion stimuli that may not adequately represent lived experiences. In this study, we tested relations between mothers' dispositional mindfulness and neural responses to their own infant in different emotion-eliciting contexts. Mothers (n = 25) engaged with their 3-month-old infants in videorecorded tasks designed to elicit negative (arm restraint) or positive (peekaboo) emotion...
January 5, 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29330534/when-increasing-population-density-can-promote-the-evolution-of-metabolic-cooperation
#13
Richard J Lindsay, Bogna J Pawlowska, Ivana Gudelj
Microbial cooperation drives ecological and epidemiological processes and is affected by the ecology and demography of populations. Population density influences the selection for cooperation, with spatial structure and the type of social dilemma, namely public-goods production or self-restraint, shaping the outcome. While existing theories predict that in spatially structured environments increasing population density can select either for or against cooperation, experimental studies with both public-goods production and self-restraint systems have only ever shown that increasing population density favours cheats...
January 12, 2018: ISME Journal
https://www.readbyqxmd.com/read/29329403/host-tree-selection-by-the-invasive-argentine-ant-hymenoptera-formicidae-in-relation-to-honeydew-producing-insects
#14
Yugo Seko, Daisuke Hayasaka, Atsushi Nishino, Taizo Uchida, Francisco Sánchez-Bayo, Takuo Sawahata
The Argentine ant, Linepithema humile (Mayr; Hymenoptera: Formicidae), is one of the world's most hazardous invasive species, and thus its eradication from Japan is important. Physical and chemical controls can be expensive and cause strong adverse effects on local terrestrial ecosystems regardless of their high efficacy. Here, presence/absence of host-tree selection by Argentine ants was investigated to understand the ant-honeydew-producing insects interactions in order to develop new cultural controls compatible with biodiversity conservation...
January 10, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29329258/association-between-haem-and-non-haem-iron-intake-and-serum-ferritin-in-healthy-young-women
#15
Isabel Young, Helen M Parker, Anna Rangan, Tania Prvan, Rebecca L Cook, Cheyne E Donges, Kate S Steinbeck, Nicholas J O'Dwyer, Hoi Lun Cheng, Janet L Franklin, Helen T O'Connor
Iron is an essential micronutrient for human health and inadequate intake may result in iron deficiency (ID) or iron deficiency anaemia (IDA). Unlike other recent studies investigating iron status in young women, this cross-sectional study analysed dietary intake and biochemical data from healthy young (18-35 years) women (n = 299) to determine the association between both haem iron (HI) and non-haem iron (NHI) intakes and serum ferritin (SF). Dietary restraint and possible inflammation secondary to obesity were also measured and accounted for, and energy intake was adjusted for using the residuals method...
January 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29328356/factor-structure-of-the-eating-disorder-examination-questionnaire-in-a-clinical-sample-of-adult-women-with-anorexia-nervosa
#16
Kathryn E Phillips, Karen M Jennings, Matthew Gregas
An exploratory factor analysis on the Eating Disorder Examination-Questionnaire (EDE-Q) is presented for a clinical sample of women with anorexia nervosa. THE EDE-Q was completed by 169 participants after admission to an inpatient unit for eating disorders. Results of the current study did not support the four-factor model presented by the EDE-Q. A new four-factor solution was obtained with two factors showing similarity to the Restraint and Eating Concern subscales of the original model. The Shape and Weight Concern items primarily loaded together on one factor, along with preoccupation with food and fear of losing control over eating, two Eating Concern items...
January 11, 2018: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29324309/the-promising-future-of-ventricular-restraint-therapy-for-the-management-of-end-stage-heart-failure
#17
REVIEW
Muhammad Naveed, Imran Shair Mohammad, Li Xue, Sara Khan, Wang Gang, Yanfang Cao, Yijie Cheng, Xingxing Cui, Chen DingDing, Yu Feng, Wang Zhijie, Zhou Xiaohui
Complicated pathophysiological syndrome associated with irregular functioning of the heart leading to insufficient blood supply to the organs is linked to congestive heart failure (CHF) which is the leading cause of death in developed countries. Numerous factors can add to heart failure (HF) pathogenesis, including myocardial infarction (MI), genetic factors, coronary artery disease (CAD), ischemia or hypertension. Presently, most of the therapies against CHF cause modest symptom relief but incapable of giving significant recovery for long-term survival outcomes...
January 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29323442/mental-health-inpatients-and-staff-members-suggestions-for-reducing-physical-restraint-a-qualitative-study
#18
Ceri Wilson, Lorna Rouse, Sarah Rae, Manaan Kar Ray
INTRODUCTION: Physical restraint has negative consequences for all involved and international calls for its reduction have emerged. Some restraint reduction interventions have been developed, but limited qualitative research explores suggestions on how to reduce physical restraint (and feasibility issues with implementation) from those directly involved. AIM: To explore mental health patients' and staff members' suggestions for reducing physical restraint. METHOD: Interviews were conducted with 13 inpatients and 22 staff members with experience of restraint on adult mental health inpatient wards in one UK National Health Service Trust...
January 11, 2018: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/29317595/hippocampal-metabolic-differences-implicate-distinctions-between-physical-and-psychological-stress-in-four-rat-models-of-depression
#19
Lanxiang Liu, Xinyu Zhou, Yuqing Zhang, Juncai Pu, Lining Yang, Shuai Yuan, Libo Zhao, Chanjun Zhou, Hanping Zhang, Peng Xie
Major depressive disorder (MDD) is a heterogeneous and multi-factorial disorder, and the underlying molecular mechanisms remain largely unknown. However, many studies have indicated that the molecular mechanisms underlying depression in response to different stress may differ. After screening, 28-30 rats were included in each model of depression (chronic unpredictable mild stress (CUMS); learned helplessness (LH); chronic restraint stress (CRS); or social defeat (SD)). Non-targeted gas chromatography-mass spectrometry was used to profile the metabolic changes in the hippocampus...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29317210/quality-indicators-in-the-treatment-of-patients-with-depression-bipolar-disorder-or-schizophrenia-consensus-study
#20
Miquel Bernardo, Consuelo de Dios, Víctor Pérez, Emilio Ignacio, Manuel Serrano, Eduard Vieta, José Joaquín Mira, Mercedes Guilabert, Miquel Roca
OBJECTIVE: To define a set of indicators for mental health care, monitoring quality assurance in schizophrenia, depression and bipolar disorders in Spain. MATERIAL AND METHOD: Qualitative research. Consensus-based study involving 6 psychiatrists on the steering committee and a panel of 43 psychiatrists working in several health services in Spain. An initial proposal of 44 indicators for depression, 42 for schizophrenia and 58 for bipolar disorder was elaborated after reviewing the literature...
January 6, 2018: Revista de Psiquiatrí́a y Salud Mental
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