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Corinne N Johnson, Gareth J Price, Corinne Faivre-Finn, Marianne C Aznar, Marcel van Herk
BACKGROUND: and Purpose: Image-guided radiotherapy (IGRT) is widely used but data directly relating setup errors to patient outcome is scarce. This study investigates the relationship between residual IGRT shifts and overall patient survival, and uses the observed relations to identify structures sensitive to radiation dose. MATERIALS AND METHODS: Residual shift data for 780 NSCLC patients was summarised for each patient over the course of treatment by determining the mean shifts, standard deviations and the vector shift in the direction of the heart...
June 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Anna Piekarska, Ewa K Berkan, Kamila M Wójcik
Non-invasive liver fibrosis assessment techniques are under development for evaluating the severity of liver disease and portal hypertension. The paper presents practical arrangements for the diagnosis and treatment of portal hypertension in patients with chronic liver disease, established in the Baveno VI Consensus Workshop for diagnosis and treatment of portal hypertension. Currently, the diagnostic standard of liver disease severity is transient elastography, which can identify patients with clinically significant portal hypertension (liver stiffness > 20 kPa)...
June 2018: Clinical and experimental hepatology
Ali Talib, Rogier de Ridder, Jan Willem Straathof, Nicole D Bouvy
Endoscopic removal of eroded Lap-Bands is a minimally invasive alternative to surgical removal that prerequires sufficient erosion through the gastric wall, that is, ≥180° of the gastro-oesophageal wall circumference. A 69-year-old woman presented with dysphagia due to a long-standing Lap-Band erosion, currently of a 60° circumference. Adhesions due to her extensive surgical history rendered surgical treatment undesirable, so a self-expanding stent was placed endoscopically to induce sufficient erosion for subsequent endoscopic removal...
June 13, 2018: BMJ Case Reports
Huaying Zhao, Changying Diao, Xiaohui Wang, Yilin Xie, Yaqing Liu, Xianzheng Gao, Jing Han, Shenglei Li
This study was aimed at exploring the effect of lncRNA BDNF-AS on cell proliferation, migration, invasion and epithelial-to-mesenchymal transition (EMT) of oesophageal cancer (EC) cells. The expression of BDNF-AS and miR-214 in tissue samples and cells was measured by qRT-PCR. The targeted relationship between BDNF-AS and miR-214 was analysed by dual-luciferase reporter assay. After cell transfection, the cell proliferation activity was assessed by MTS method, while the migrating and invading abilities were evaluated by transwell assay...
June 12, 2018: Journal of Cellular and Molecular Medicine
Katie E O' Sullivan, Adriana J Michielsen, Esther O' Regan, Mary C Cathcart, Gillian Moore, Eamon Breen, Ricardo Segurado, John V Reynolds, Joanne Lysaght, Jacintha O' Sullivan
Signal transducers and activator of transcription (STAT)-3 is activated in cancers, where it promotes growth, inflammation, angiogenesis, and inhibits apoptosis. Tissue microarrays were generated using tissues from 154 patients, with oesophageal adenocarcinoma (OAC) ( n = 116) or squamous cell carcinoma (SCC) ( n = 38) tumours. The tissues were stained for pSTAT3 and IL-6R using immunohistochemistry. The OE33 (OAC) and OE21 (SCC) cell lines were treated with the STAT3 inhibitor, STATTIC. The Univariate cox regression analysis revealed that a positive pSTAT3 in SCC was adversely associated with survival (Hazard ratio (HR) 6...
June 10, 2018: International Journal of Molecular Sciences
Fang Wang, Maeda Yasuko, Vladimir Zachar, Tahera Ansari, Jeppe Emmersen
This study explored the feasibility of constructing a tissue engineered muscle layer in the oesophagus using oesophageal acellular matrix (OAM) scaffolds and human aortic smooth muscle cells (hASMCs) or human adipose-derived stem cells (hASCs). The second objective was to investigate the effect of hypoxic preconditioning of seeding cells on cell viability and migration depth. Our results demonstrated that hASMCs and hASCs could attach and adhere to the decellularized OAM scaffold and survive and proliferate for at least 7 days depending on the growth conditions...
June 8, 2018: Biochemical and Biophysical Research Communications
Harry Kaltsidis, Wasat Mansoor, Jung-Hoon Park, Ho-Young Song, Derek William Edwards, Hans-Ulrich Laasch
Oesophageal stents are widely used for palliating dysphagia from malignant obstruction. They are also used with increasing frequency in the treatment of oesophageal perforation, as well as benign strictures from a variety of causes. Improved oncological treatments have led to prolonged survival of patients treated with palliative intent; as a consequence, stents need to function and last longer in order to avoid repeat procedures. There is also increasing need for meticulous procedure planning, careful selection of the device most appropriate for the individual patient and planned follow-up...
June 11, 2018: British Journal of Radiology
Rajeev Sathasivam, Gopinath Bussa, Yirupaiahgari Viswanath, Reece-Bolton Obuobi, Talvinder Gill, Anil Reddy, Venkat Shanmugam, Andy Gilliam, Prem Thambi
In laparoscopic 'paraoesophageal hernia' (POH) repair, non-absorbable suture materials have been used to close the crural defects. More recently, various types of prosthetic mesh have been utilized to repair the defect. We conducted a systematic review with meta-analysis of the recent and up to-date studies incorporating 942 POH repairs. We examined the rates of recurrence, reoperation, and complication rates alongside operative time of these two techniques in the management POH. Randomized controlled trials (RCT) and observational studies comparing mesh hiatal hernioplasty versus Suture cruroplasty for Paraoesophageal hernia were selected by searching Medline, Embase, and Cochrane Central database published between January 1995 and December 2016...
June 7, 2018: Asian Journal of Surgery
Edith Lahner, Marina Capasso, Marilia Carabotti, Bruno Annibale
BACKGROUND: Pernicious anaemia (PA) is associated with increased gastric cancer risk, but the evidence is conflicting regarding the associated risk of other cancers. AIM: To systematically determine the incidence rates of gastro-intestinal cancers other than gastric cancers (GI-other-than-GC) and non-gastrointestinal cancers (non-GIC) in PA adults, globally and per tumour site, and the risk associated with PA for GI-other than GC and non-GIC. METHODS: Studies of PA patients reporting the incidence of GI-other-than-GCs and non-GICs were identified with MEDLINE (PubMed)-EMBASE (from first date available to April 2017)...
May 24, 2018: Digestive and Liver Disease
Ryohei Ono, Hidemitsu Ogino, Jun Kawachi, Rai Shimoyama, Hiroyuki Kashiwagi, Naoko Isogai, Katsunori Miyake, Ryuta Fukai, Takaaki Murata, Yuto Igarashi, Nobuaki Shinozaki
INTRODUCTION: Small intestinal metastasis from oesophageal carcinoma is rare. We report a case of small intestinal metastases from oesophageal carcinoma presenting as a perforation and discuss the aetiology with other cases of small intestinal metastasis from oesophageal carcinoma reported in previous literature. PRESENTATION: An 86-year-old man presented with fever and coughing. He had choked while eating and had history of weight loss. He was diagnosed with aspiration pneumonia...
June 5, 2018: International Journal of Surgery Case Reports
Thuy-My N Nguyen, Richard Hummel, Tim Bright, Sarah K Thompson, Bjorn Tornqvist, David I Watson
BACKGROUND: Most oesophageal outcome research focuses on surgical treatment, despite most patients not undergoing surgery as they are unfit or have metastatic disease. Few studies have evaluated the patterns of care for all patients presenting with oesophageal cancer. METHODS: All patients with oesophageal cancer, and high-grade dysplasia (HGD), presented at the South Australian state-wide upper gastrointestinal cancer multidisciplinary team from 2012 to 2015 were reviewed to determine the patterns of presentation and treatment...
June 9, 2018: ANZ Journal of Surgery
Matteo Melloni, Veronica Lazzari, Emanuele Asti, Luigi Bonavina
Bile reflux into the gastric stump and then into the oesophagus is a common event after distal gastrectomy and Billroth II reconstruction. In addition to typical symptoms of nausea, epigastric pain and bile vomiting, acid reflux can also occur in patients with concomitant hiatus hernia and lower oesophageal sphincter incompetency. Diverting the bile away from the oesophagus by conversion into a Roux-en-Y anastomosis or by completion gastrectomy and Roux-en-Y esophagojejunostomy have so far represented the mainstay of treatment...
June 8, 2018: BMJ Case Reports
Ming Yu, Sean K Maden, Matthew Stachler, Andrew M Kaz, Jessica Ayers, Yuna Guo, Kelly T Carter, Amber Willbanks, Tai J Heinzerling, Rachele M O'Leary, Xinsen Xu, Adam Bass, Apoorva K Chandar, Amitabh Chak, Robin Elliott, Joseph E Willis, Sanford D Markowitz, William M Grady
OBJECTIVE: To identify and characterise DNA methylation subtypes in oesophageal adenocarcinoma (EAC) and its precursor Barrett's oesophagus (BE). DESIGN: We performed genome-wide DNA methylation profiling on samples of non-dysplastic BE from cancer-free patients (n=59), EAC (n=23), normal squamous oesophagus (n=33) and normal fundus (n=9), and identified methylation subtypes using a recursively partitioned mixture model. We assessed genomic alterations for 9 BE and 22 EAC samples with massively parallel sequencing of 243 EAC-associated genes, and we conducted integrative analyses with transcriptome data to identify epigenetically repressed genes...
June 8, 2018: Gut
Sudarshan R Jadcherla
No abstract text is available yet for this article.
June 8, 2018: Acta Paediatrica
Ricardo Küttner-Magalhães, Mário Dinis-Ribeiro, Marco J Bruno, Ricardo Marcos-Pinto, Carla Rolanda, Arjun D Koch
Introduction: Endoscopic mucosal resection and endoscopic submucosal dissection are demanding procedures. This study aims to establish face, content and expert validity of the live porcine model in performing endoscopic mucosal resection, endoscopic submucosal dissection, complication management and to assess it as a training tool. Material and methods: Tutors and trainees participating in live porcine model endoscopic mucosal resection and endoscopic submucosal dissection workshops filled out a questionnaire regarding the realism of the model compared to human setting and its role as a learning tool...
May 2018: United European Gastroenterology Journal
Margreet van Putten, Brian T Johnston, Liam J Murray, Anna T Gavin, Damian T McManus, Shivaram Bhat, Richard C Turkington, Helen G Coleman
Background: A systematic review suggests that 25% of oesophageal adenocarcinomas (OAC) are 'missed' at index endoscopy for Barrett's oesophagus (BO); however, this included few population-based studies and may be an overestimate. Objective: The objective of this article is to quantify the 'missed' rates of high-grade dysplasia (HGD) and OAC at index BO endoscopy. Methods: Patients from the Northern Ireland BO register diagnosed between 1993 and 2010 ( n  = 13,159) were linked to the Northern Ireland Cancer Registry to identify patients who developed OAC or HGD...
May 2018: United European Gastroenterology Journal
Elizabeth C Smyth, Russell D Petty
No abstract text is available yet for this article.
June 4, 2018: Lancet
Kohei Shitara, Mustafa Özgüroğlu, Yung-Jue Bang, Maria Di Bartolomeo, Mario Mandalà, Min-Hee Ryu, Lorenzo Fornaro, Tomasz Olesiński, Christian Caglevic, Hyun C Chung, Kei Muro, Eray Goekkurt, Wasat Mansoor, Raymond S McDermott, Einat Shacham-Shmueli, Xinqun Chen, Carlos Mayo, S Peter Kang, Atsushi Ohtsu, Charles S Fuchs
BACKGROUND: Patients with advanced gastric or gastro-oesophageal junction cancer that progresses on chemotherapy have poor outcomes. We compared pembrolizumab with paclitaxel in patients with advanced gastric or gastro-oesophageal junction cancer that progressed on first-line chemotherapy with a platinum and fluoropyrimidine. METHODS: This randomised, open-label, phase 3 study was done at 148 medical centres in 30 countries. Eligible patients were randomised (1:1) in blocks of four per stratum with an interactive voice-response and integrated web-response system to receive either pembrolizumab 200 mg every 3 weeks for up to 2 years or standard-dose paclitaxel...
June 4, 2018: Lancet
J R Conner, R Kirsch
No abstract text is available yet for this article.
June 2018: Alimentary Pharmacology & Therapeutics
R K Pai, A Bredenoord, B G Feagan, V Jairath
No abstract text is available yet for this article.
June 2018: Alimentary Pharmacology & Therapeutics
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