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https://www.readbyqxmd.com/read/29223560/the-relationship-between-intestinal-and-oral-mucosa-microcirculation-in-anaesthetized-horses
#1
Klaus Hopster, Stephan Neudeck, Liza Wittenberg-Voges, Sabine Br Kästner
OBJECTIVE: To compare alteration in intestinal blood flow in anaesthetized horses with changes in oral mucosa blood flow. STUDY DESIGN: Prospective, randomized clinical study. ANIMALS: Eight warmblood horses. METHODS: After induction with guaifenesin and ketamine, anaesthesia was maintained with isoflurane at 1.5 vol% in oxygen. The tissue blood flow was measured using laser Doppler flowmetry at the jejunum, colon, rectal mucosa, oesophageal mucosa and the oral mucosa...
August 18, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29222714/domperidone-prolongs-oral-to-duodenal-transit-time-in-video-capsule-endoscopy
#2
Michael Mcfarlane, B Liu, C Nwokolo
PURPOSE: Domperidone is thought to accelerate gastric emptying via D2 receptor antagonism at the gastro-oesophageal and gastro-duodenal junctions. Listed in the BNF as a prokinetic anti-emetic, it has been used in video capsule endoscopy (VCE) to accelerate capsule delivery to the small intestine. We audited VCEs performed at UHCW from 2011, when as standard practice, domperidone was given pre-VCE, to 2012, after its discontinuation due to doubts about its effectiveness. METHODS: Thirty-one patients received oral domperidone 20 mg pre-VCE...
December 8, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29222094/case-based-discussion-from-the-neonatal-intensive-care-unit-a-case-of-an-intentional-oesophageal-intubation
#3
Katharine Jamieson, Stephanie Boyd, Susern Tan, Davina Wong, Paul James, Andrew Durward, Andrew Nyman
Tracheal agenesis (TA) is a rare congenital defect consisting of complete or partial absence of the trachea below the larynx. Antenatal diagnosis is challenging, and most cases are detected in the postnatal period. Airway management of such cases, particularly in the absence of antenatal diagnosis, can be challenging. Various methods of management have been described but with limited success, and overall prognosis remains very poor. We present an unexpected case of TA, highlighting management issues and diagnostic methods...
December 8, 2017: Thorax
https://www.readbyqxmd.com/read/29221724/downregulation-of-klk13-promotes-the-invasiveness-and-metastasis-of-oesophageal-squamous-cell-carcinoma
#4
Qingfeng Lin, Weidong Mao, Qingquan Wu, Xiaoting He, Suqing Li, Yanxin Fan, Jie Chen, Tingting Feng, Xiufeng Cao
KLK13 downregulation occurs in tumour tissues in comparison with adjacent normal tissues from patients with oesophageal squamous cell carcinoma (OSCC). KLK13 mRNA levels were tested in OSCC tumour tissues and adjacent noncancerous tissues from 138 patients. In addition, the correlation between KLK13 mRNA levels and OSCC clinicopathologic features was analysed. KLK13 mRNA levels decreased notably in tumour tissues compared with those in adjacent noncancerous tissues. And decreased KLK13 mRNA levels indicated significant correlations with higher tumour grade, elevated TNM (UICC, 2009) stage classification, deeper infiltration and more lymph node metastases...
December 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29221569/functional-analysis-of-the-igf-system-in-milk
#5
REVIEW
Andreas Hoeflich, Zianka Meyer
The development of milk during evolution is considered a more recent step to provide the neonate with adequate amounts of energy, nutrients, and specific hormonal signals thereby, granting a fast and efficient rate of postnatal growth and development. Since the insulin- or the insulin-like growth factor (IGF) systems were evolved much earlier, it can be assumed that the functionality of the IGF-system has been integrated into the novel matrix milk containing casein and whey proteins from the beginnings. In fact, IGFs and IGF-binding proteins (IGFBPs) are abundantly present in milk, which is particularly true for fore-milk or colostrum and the potential effects of milk-borne IGF-compounds on the consuming organisms have in fact been addressed by several studies...
August 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29221258/neoadjuvant-dcf-vs-acf-for-resectable-oesophageal-squamous-cell-carcinoma
#6
EDITORIAL
Vasiliki Michalarea, Elizabeth C Smyth
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221240/composite-metrics-in-response-assessment-new-hope-in-oesophageal-cancer
#7
EDITORIAL
Janusz Włodarczyk, Jarosław Kużdżał
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221227/pet-guided-treatment-algorithms-in-oesophageal-cancer-the-promise-of-the-near-future
#8
EDITORIAL
Lioe-Fee de Geus-Oei, Marije Slingerland
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221150/comparison-of-gross-tumor-volume-of-primary-oesophageal-cancer-based-on-contrast-enhanced-three-dimensional-four-dimensional-and-cone-beam-computed-tomography
#9
Chao-Yue Hu, Jian-Bin Li, Jin-Zhi Wang, Wei Wang, Feng-Xiang Li, Yan-Luan Guo
Background: To explore motion information included in 3DCT, 4DCT and CBCT by comparing volumetric and positional differences of GTV. Results: Independent of tumor location, significant differences were observed among volumes [IGTV10 > (IGTVCBCT or IGTVMIP) > (GTV3D or GTV4D50)]. The underestimations or overestimations between IGTV10 and IGTVCBCT were larger than those between IGTV10 and IGTVMIP (p < 0.001-0.011; p < 0.001-0.023). For upper oesophageal tumors, GTV4D50/IGTVCBCT negatively correlated with motion vector (r = -0...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29218619/cervical-ultrasonography-has-no-additional-value-over-negative-18f-fdg-pet-ct-scans-for-diagnosing-cervical-lymph-node-metastases-in-patients-with-oesophageal-cancer
#10
Lucas Goense, Jihane Meziani, Peter S N van Rossum, Frank J Wessels, Marnix G E H Lam, Richard van Hillegersberg, Jelle P Ruurda
OBJECTIVES: To investigate the additional value of cervical ultrasonography over 18F-FDG PET/CT for diagnosing cervical lymph node metastases in patients with newly diagnosed oesophageal cancer. METHODS: Between January 2013 and January 2016, 163 patients with newly diagnosed oesophageal cancer underwent both cervical ultrasonography and 18F-FDG PET/CT at a tertiary referral centre in the Netherlands. Retrospective clinical data analysis was performed to assess the diagnostic value of cervical ultrasonography and 18F-FDG PET/CT for the detection of cervical lymph node metastases...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29217321/bronchoscopy-as-a-screening-tool-for-symptomatic-tracheomalacia-in-oesophageal-atresia
#11
Hemanshoo Thakkar, Manasvi Upadhyaya, Iain E Yardley
AIM: Oesophagealatresia/tracheo-oesophageal fistula (OA-TOF) is associated with tracheomalacia (TM). In our institution it is routine for OA-TOF patients to undergo dynamic flexible bronchoscopy (DFB) assessing both the site of the fistula and the presence or absence of TM. We aimed to determine the value of this investigation as a screening tool to predict subsequent symptomatic tracheomalacia in these patients. METHODS: All patients with OA-TOF who underwent DFB at the time of initial repair between June 2014 and November 2016 were included prospectively...
November 11, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29216650/-have-multimodal-and-perioperative-therapeutic-strategies-changed-the-survival-after-oncological-oesophageal-surgery-in-the-last-two-decades-a-retrospective-cohort-analysis-over-23-years
#12
Philipp Lingohr, Julia Zender, Cornelius van Beekum, Jonas Dohmen, Hanno Matthaei, Nico Schaefer, Jörg C Kalff, Tim Oliver Vilz
Background Esophageal malignoma is among the most frequent causes for cancer-related deaths. The only definite curative therapy is esophagectomy embedded in various multimodal treatment regimens. The aim of this study was to evaluate long-term development after esophageal surgery in the last two decades in order to observe possible trends and their influence on short, medium and long term survival. Patients and Methods Cases of 301 patients who underwent esophagectomy between 1989 and 2012 were analysed retrospectively...
December 7, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29216556/influence-of-water-activity-and-temperature-on-growth-and-fumonisin-production-by-fusarium-proliferatum-strains-on-irradiated-wheat-grains
#13
Eugenia Cendoya, María Del Pilar Monge, Stella Maris Chiacchiera, María Cecilia Farnochi, María Laura Ramirez
Wheat is the most important cereal consumed by the Argentine population. In previous studies performed in durum and common wheat grains in this country it has been observed fumonisin contamination as well as high incidence of Fusarium proliferatum. Fumonisins are toxic fungal metabolites, and consumption of fumonisin-contaminated maize has been epidemiologically associated with oesophageal cancer and neural tube defects in some human populations. Using irradiated wheat-grains, the effects of abiotic factors, temperature (15, 25, and 30°C) and water activity (aW; 0...
December 4, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29212807/the-independent-and-interactive-effects-of-incremental-heat-strain-orthostatic-stress-and-mild-hypohydration-on-cerebral-perfusion
#14
Rebekah A I Lucas, Luke C Wilson, Philip N Ainslie, Jui-Lin Fan, Kate N Thomas, James D Cotter
The purpose of this study was to identify the dose-dependent effects of heat strain and orthostasis (via lower-body negative pressure; LBNP), with and without mild hypohydration, on systemic function and cerebral perfusion. Eleven males (Mean ±SD: 27 ±7 y; body mass 77 ±6 kg), resting supine in a water-perfused suit, underwent progressive passive heating [0.5°C increments in core temperature (Tc, oesophageal to +2.0°C)] whilst euhydrated (EUH) or hypohydrated (HYPO, 1.5-2% body mass deficit). At each thermal state, mean cerebral artery blood velocity (MCAvmean, Transcranial Doppler), partial pressure of end-tidal carbon dioxide (PETCO2), heart rate (HR) and mean arterial blood pressure (MAP, photoplethysmography) were measured continuously during LBNP (0, -15, -30, -45 mm Hg)...
December 6, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29212656/the-relevance-and-implications-of-signet-ring-cell-adenocarcinoma-of-the-oesophagus
#15
REVIEW
Christopher William Bleaney, Mickhaiel Barrow, Stephen Hayes, Yeng Ang
AIM: To review the current understanding of signet-ring type oesophageal adenocarcinoma including evidence for prognosis. METHODS: We conducted a literature search of nine healthcare literature databases for articles detailing the biology and clinical outcomes of signet-ring cell adenocarcinoma of the oesophagus. The impact of signet-ring cell morphology was analysed and detailed in written text and tabular format. Current understanding of the biology of signet-ring cell adenocarcinoma of the oesophagus was summarised...
December 6, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29211685/optimisation-of-sampling-parameters-for-standardised-exhaled-breath-sampling
#16
Sophie L F Doran, Andrea Romano, George B Hanna
The lack of standardisation of breath sampling is a major contributing factor to the poor repeatability of results and hence represents a barrier to the adoption of breath tests in clinical practice. On-line and bag breath sampling have advantages but do not suit multicentre clinical studies whereas storage and robust transport are essential for the conduct of wide-scale studies. Several devices have been developed to control sampling parameters and to concentrate volatile organic compounds (VOCs) onto thermal desorption (TD) tubes and subsequently transport those tubes for laboratory analysis...
December 6, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29210016/amphibiophilus-mooiensis-n-sp-nematoda-amphibiophilidae-a-parasite-of-amietia-delalandii-dum%C3%A3-ril-bibron-amphibia-pyxicephalidae-from-south-africa
#17
Roman Svitin, Louis Du Preez
Four species of the genus Amphibiophilus Skrjabin, 1916 from pyxycephalid frogs in southern and central Africa are currently recognised as valid. Several specimens of Amphibiophilus were found in material from the common river frog, Amietia delalandii (Duméril & Bibron) (Amphibia: Pyxicephalidae), collected in Potchefstroom (North-West Province, South Africa). These specimens clearly differ from all previously known species by the shape of the distal end of the spicule, the shape of the gubernaculum and the structure of the synlophe...
December 5, 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/29209536/activating-her2-mutations-as-emerging-targets-in-multiple-solid-cancers
#18
REVIEW
Claire M Connell, Gary J Doherty
The epidermal growth factor receptor (EGFR) family of transmembrane receptor tyrosine kinases activates signalling pathways regulating cellular proliferation and survival. HER2 is a non-ligand-binding member of this family and exerts its activity through heterodimerisation with other EGFR family members. HER2 functional activation promotes oncogenesis, leading to the investigation of HER2-directed agents in cancers with HER2 alterations. This has been best characterised in the context of HER2 gene amplification in breast and gastro-oesophageal cancers, for which HER2-directed drugs form part of standard treatment regimens...
2017: ESMO Open
https://www.readbyqxmd.com/read/29209106/noncoding-rnas-as-drivers-of-the-phenotypic-plasticity-of-oesophageal-mucosa
#19
EDITORIAL
Matteo Fassan, Sonia Facchin, Giada Munari, Giuseppe Nicolò Fanelli, Greta Lorenzon, Edoardo Savarino
The histological commitment of the lower oesophageal mucosa largely depends on a complex molecular landscape. After extended inflammatory insult due to gastroesophageal reflux disease, squamous oesophageal mucosa may differentiate into columnar metaplastic mucosa. In this setting, the presence of intestinal metaplasia is considered the starting point of Barrett's carcinogenetic cascade. Aside from secondary prevention strategies for Barrett's mucosa (BM) patients, there are multiple endoscopic ablative therapies available for BM eradication and for the replacement of metaplastic epithelia with a neosquamous mucosa...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29208442/defining-a-global-research-and-policy-agenda-for-betel-quid-and-areca-nut
#20
REVIEW
Hedieh Mehrtash, Kalina Duncan, Mark Parascandola, Annette David, Ellen R Gritz, Prakash C Gupta, Ravi Mehrotra, Amer Siddiq Amer Nordin, Paul C Pearlman, Saman Warnakulasuriya, Chi-Pang Wen, Rosnah Binti Zain, Edward L Trimble
Betel quid and areca nut are known risk factors for many oral and oesophageal cancers, and their use is highly prevalent in the Asia-Pacific region. Additionally, betel quid and areca nut are associated with health effects on the cardiovascular, nervous, gastrointestinal, metabolic, respiratory, and reproductive systems. Unlike tobacco, for which the WHO Framework Convention on Tobacco Control provides evidence-based policies for reducing tobacco use, no global policy exists for the control of betel quid and areca nut use...
December 2017: Lancet Oncology
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