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https://www.readbyqxmd.com/read/29682865/efficacy-of-forced-air-warming-for-preventing-perioperative-hypothermia-and-related-complications-in-patients-undergoing-laparoscopic-surgery-a-randomized-controlled-trial
#1
Shu-Fen Su, Hsiao-Chi Nieh
BACKGROUND: Perioperatively, unexpected hypothermia may cause adverse surgical outcomes. However, few studies have explored the efficacy of forced-air warming in patients undergoing laparoscopic surgery. AIM/OBJECTIVE: To determine the efficacy of forced-air warming for preventing perioperative hypothermia and complications in patients undergoing laparoscopic surgery. METHODS: A total of 127 participants undergoing laparoscopic thoracic or abdominal surgery were recruited between January and November 2015...
April 23, 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29681616/progress-in-preventive-therapy-for-cancer-a-reminiscence-and-personal-viewpoint
#2
REVIEW
Jack Cuzick
Prophylactic drug treatment with aspirin, statins and anti-hypertensive agents has had a major impact on the incidence of cardiovascular disease and is now well established. Progress in therapeutic cancer prevention has been much slower; only recently have effective agents been clearly established. Breast cancer has led the way and endocrine agents used to treat it-notably tamoxifen and the aromatase inhibitors-have now been shown to have a substantial preventive effect as well. However, these agents carry some toxicity and thus identifying high-risk women who are likely to benefit most is a key priority...
April 23, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29679768/comparison-of-proaqt-pulsioflex%C3%A2-and-oesophageal-doppler-for-intraoperative-haemodynamic-monitoring-during-intermediate-risk-abdominal-surgery
#3
Grégoire Weil, Cyrus Motamed, Alexandre Eghiaian, Xavier Monnet, Stéphanie Suria
OBJECTIVE: To compare cardiac index (CI) between Proaqt/PulsioFlex® and esophageal Doppler (OD) and the ability of the PulsioFlex® to track CI changes induced by fluid challenge and secondly to assess the impact of the time interval between two auto-calibrations of PulsioFlex® on the accuracy of the measured CI. METHODS: In a single hospital, 49 intermediate-risk oncologic abdominal surgery patients were included in an observational study. We measured the cardiac Index (CI) provided by OD and by the Proaqt/PulsioFlex® before and after internal calibration, which were performed randomly at specific intervals after the initial one (30, 60, 90 and 120min)...
April 18, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29679113/increased-evidence-for-the-prognostic-value-of-fdg-uptake-on-late-treatment-pet-in-non-tumour-affected-oesophagus-in-irradiated-patients-with-oesophageal-carcinoma
#4
Yimin Li, Frank Hofheinz, Christian Furth, Chen Lili, Wu Hua, Pirus Ghadjar, Sebastian Zschaeck
PURPOSE: 18 F-FDG uptake in irradiated non-tumour-affected oesophagus (NTO) on restaging PET is a potential surrogate for the measurement of radiation-induced inflammation. Radiation-induced inflammation itself has been shown to be of high prognostic relevance in patients undergoing preoperative radiochemotherapy (RCT) for locally advanced oesophageal cancer. We assessed the prognostic relevance of FDG uptake in the NTO in an independent cohort of patients treated with definitive RCT...
April 21, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29672466/a-comparative-study-of-quantitative-assessment-with-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-and-endoscopic-ultrasound-in-oesophageal-cancer
#5
Aditya Borakati, Abdul Razack, Chris Cawthorne, Rajarshi Roy, Sharjeel Usmani, Najeeb Ahmed
OBJECTIVES: This study aims to assess the correlation between PET/CT and endoscopic ultrasound (EUS) parameters in patients with oesophageal cancer. PATIENTS AND METHODS: All patients who had complete PET/CT and EUS staging performed for oesophageal cancer at our centre between 2010 and 2016 were included. Images were retrieved and analysed for a range of parameters including tumour length, volume and position relative to the aortic arch. RESULTS: Seventy patients were included in the main analysis...
April 18, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29669820/cancer-mortality-in-an-international-cohort-of-reinforced-plastics-workers-exposed-to-styrene-a-reanalysis
#6
Dana Loomis, Neela Guha, Manolis Kogevinas, Vincenzo Fontana, Valerio Gennaro, Henrik A Kolstad, Damien Martin McElvenny, Markku Sallmén, Rodolfo Saracci
OBJECTIVE: To investigate the carcinogenicity of styrene by reanalysing data from a previous international cohort study of workers in the reinforced plastics industry. METHODS: Mortality from cancers of prior interest was analysed with more detailed consideration of exposure-response relations and an updated classification of leukaemias and lymphomas in data from a previous international cohort study of 37 021 reinforced plastics workers exposed to airborne styrene...
April 17, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29666806/the-frontline-of-esophageal-cancer-treatment-questions-to-be-asked-and-answered
#7
REVIEW
Cheng-Che Tu, Po-Kuei Hsu
Achieving a good treatment for esophageal cancer is a great challenge. For early stage cancer, endoscopic treatment is considered the first line and a possible curative therapy. Chemotherapy, radiotherapy, and surgery are all used for the treatment of locally advanced esophageal cancer, administered either alone or combined. Some combinations have proven to be feasible, effective, and superior, such as neoadjuvant chemoradiation (CRT) plus surgery in the Chemoradiotherapy for Oesophageal Cancer Followed by Surgery Study (CROSS) trial...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666340/genetic-variants-of-foxp1-and-foxf1-are-associated-with-the-susceptibility-of-oesophageal-adenocarcinoma-in-chinese-population
#8
Jie Zhang, Jiebin Chen, Tianheng Ma, Huimin Guo, Bin Yang
This study aimed to investigate whether the genetic variants of CRTC1, BARX1, FOXP1 and FOXF1 are associated with the development of oesophageal adenocarcinoma (OA) in Chinese population. A total of 744 OA patients and 1138 controls were included in this study. Here we genotyped four SNPs, rs10419226 of CRTC1, rs11789015 of BARX1, rs2687201 of FOXP1 and rs3111601 of FOXF1. The chi-square test was used to compare the genotype and allele frequencies between the patients and controls. The student's t-test was used to compare FOXP1 expression in the tumour and the adjacent normal tissues...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29666202/nutritional-role-of-amniotic-fluid-clues-from-infants-with-congenital-obstruction-of-the-digestive-tract
#9
Nigel J Hall, Melanie Drewett, David Burge
AIMS: To investigate the role played by amniotic fluid in late fetal nutrition by analysis of infants born with digestive tract atresia. METHODS: Birth weight (BW), gestational age and gender of infants born with oesophageal (OA), duodenal (DA), jejunal (JA) and ileal atresia (IA) were recorded and BW Z-scores compared. Infants with incomplete obstruction (stenosis), chromosomal or syndromic conditions and multiple congenital malformations were excluded. Term infants admitted with suspected postnatal intestinal obstruction in whom no congenital malformation was found were used as a control group...
April 17, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29665323/introducing-a-novel-highly-prognostic-grading-scheme-based-on-tumour-budding-and-cell-nest-size-for-squamous-cell-carcinoma-of-the-uterine-cervix
#10
Moritz Jesinghaus, Johanna Strehl, Melanie Boxberg, Frido Brühl, Adrian Wenzel, Björn Konukiewitz, Anna M Schlitter, Katja Steiger, Arne Warth, Andreas Schnelzer, Marion Kiechle, Matthias W Beckmann, Aurelia Noske, Arndt Hartmann, Grit Mehlhorn, Martin C Koch, Wilko Weichert
A novel histopathological grading system based on tumour budding and cell nest size has recently been shown to outperform conventional (WHO-based) grading algorithms in several tumour entities such as lung, oral, and oesophageal squamous cell carcinoma (SCC) in terms of prognostic patient stratification. Here, we tested the prognostic value of this innovative grading approach in two completely independent cohorts of SCC of the uterine cervix. To improve morphology-based grading, we investigated tumour budding activity and cell nest size as well as several other histomorphological factors (e...
April 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29665158/peanut-gastro-intestinal-delivery-oral-immunotherapy-in-adolescents-results-of-the-build-up-phase-of-a-randomized-double-blind-placebo-controlled-trial-pita-study
#11
Jean-Luc Fauquert, Elodie Michaud, Bruno Pereira, Lise Bernard, Nelly Gourdon-Dubois, Paul-Olivier Rouzaire, Emmanuelle Rochette, Etienne Merlin, Bertrand Evrard
BACKGROUND: Oral immunotherapy to peanut is effective in desensitizing patients but has significant side effects including anaphylaxis and gastro-intestinal symptoms. In most protocols peanut is administered in a vehicle food. OBJECTIVE: In an exclusively adolescent population, we tested a new approach using sealed capsules of peanut (Gastro-Intestinal Delivery Oral Immunotherapy or GIDOIT) in order to bypass the upper gastro-intestinal tract. The primary aim was to assess the efficacy of the oral build-up phase of GIDOIT and the secondary aim to analyse its safety...
April 17, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29663014/prediction-and-diagnosis-of-interval-metastasis-after-neoadjuvant-chemoradiotherapy-for-oesophageal-cancer-using-18-f-fdg-pet-ct
#12
Lucas Goense, Jelle P Ruurda, Brett W Carter, Penny Fang, Linus Ho, Gert J Meijer, Richard van Hillegersberg, Wayne L Hofstetter, Steven H Lin
OBJECTIVE: During neoadjuvant chemoradiotherapy for oesophageal cancer, or in the interval prior to surgery, some patients develop systemic metastasis. This study aimed to evaluate the diagnostic performance of 18 F-FDG PET/CT for the detection of interval metastasis and to identify predictors of interval metastases in a large cohort of oesophageal cancer patients. METHODS: In total, 783 consecutive patients with potentially resectable oesophageal cancer who underwent chemoradiotherapy and pre- and post-treatment 18 F-FDG PET/CT between 2006 and 2015 were analyzed from a prospectively maintained database...
April 16, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29659787/large-dissecting-intramural-haematoma-of-the-oesophagus-and-stomach-and-major-gastro-oesophageal-bleeding-after-transoesophageal-echocardiography-during-transcatheter-aortic-valve-replacement-procedures
#13
Rebeca Mata Caballero, Juan Francisco Oteo Domínguez, Susana Mingo Santos, Arturo Garcia Touchard, Javier Goicolea Ruigómez
No abstract text is available yet for this article.
April 6, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29658114/proton-pump-inhibitor-use-and-cancer-mortality
#14
Siri A Tvingsholm, Christian Dehlendorff, Kell Østerlind, Søren Friis, Marja Jäättelä
Proton pump inhibitors (PPIs) are commonly used as a supplement to cancer therapy. Yet, their effect on cancer mortality is largely unknown. Using data from Danish nationwide registries and Cox models regressing of both propensity scores and drug use, we estimated hazard ratios with 95% confidence intervals (CIs) for cancer-specific and non-cancer death among PPI users (≥2 prescriptions within six months after diagnosis; n=36,066) compared with nonusers (<2 prescriptions, n=311,853) or users of histamine H2 -receptor antagonists (H2 RA; n=5,152)...
April 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29657612/deal-a-death-blow-hcc-in-cirrhotics-thrombotic-complications-their-frequency-characteristics-and-risk-factors
#15
Khalid Mahmood, Iftikhar Haider Naqvi, Aamer Mahmood, Syed Muhammad, Noor Muhammad
Introduction: The hepatocellular carcinoma (HCC), being the commonest primary cancer, holds the sixth slot in the list of common cancers worldwide. Thrombotic complications in the form of portal vein tumour thrombosis (PVTT) and bland portal vein thrombosis with HCC are common with a bad prognosis. Aim: The study aims to determine the demographic, clinical, and biochemical parameters of HCC patients. The study also compares the clinical and biochemical parameters among patients having HCC with and without thrombotic complication...
2018: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29650964/tspan15-interacts-with-btrc-to-promote-oesophageal-squamous-cell-carcinoma-metastasis-via-activating-nf-%C3%AE%C2%BAb-signaling
#16
Baozhu Zhang, Zhao Zhang, Lei Li, Yan-Ru Qin, Haibo Liu, Chen Jiang, Ting-Ting Zeng, Meng-Qing Li, Dan Xie, Yan Li, Xin-Yuan Guan, Ying-Hui Zhu
Beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC) is crucial for the degradation of IκBα. Our previous transcriptome sequencing analysis revealed that tetraspanin 15 (TSPAN15) was significantly upregulated in clinical oesophageal squamous cell carcinoma (OSCC) tissues. Here, we show that high TSPAN15 expression in OSCC tissues is significantly associated with lymph node and distant metastasis, advanced clinical stage, and poor prognosis. Elevated TSPAN15 expression is, in part, caused by the reduction of miR-339-5p...
April 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29650363/chemotherapy-versus-chemoradiotherapy-after-surgery-and-preoperative-chemotherapy-for-resectable-gastric-cancer-critics-an-international-open-label-randomised-phase-3-trial
#17
Annemieke Cats, Edwin P M Jansen, Nicole C T van Grieken, Karolina Sikorska, Pehr Lind, Marianne Nordsmark, Elma Meershoek-Klein Kranenbarg, Henk Boot, Anouk K Trip, H A Maurits Swellengrebel, Hanneke W M van Laarhoven, Hein Putter, Johanna W van Sandick, Mark I van Berge Henegouwen, Henk H Hartgrink, Harm van Tinteren, Cornelis J H van de Velde, Marcel Verheij
BACKGROUND: Both perioperative chemotherapy and postoperative chemoradiotherapy improve survival in patients with resectable gastric cancer from Europe and North America. To our knowledge, these treatment strategies have not been investigated in a head to head comparison. We aimed to compare perioperative chemotherapy with preoperative chemotherapy and postoperative chemoradiotherapy in patients with resectable gastric adenocarcinoma. METHODS: In this investigator-initiated, open-label, randomised phase 3 trial, we enrolled patients aged 18 years or older who had stage IB- IVA resectable gastric or gastro-oesophageal adenocarcinoma (as defined by the American Joint Committee on Cancer, sixth edition), with a WHO performance status of 0 or 1, and adequate cardiac, bone marrow, liver, and kidney function...
April 9, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29648673/structured-diagnostic-approach-and-risk-assessment-in-mucous-membrane-pemphigoid-with-oesophageal-involvement
#18
Sandrine Benoit, Michael Scheurlen, Matthias Goebeler, Johanna Stoevesandt
Oesophageal involvement in mucous membrane pemphigoid is considered rare, but it may be underdiagnosed. To assess the incidence of oesophageal involvement in a group of patients with newly diagnosed mucous membrane pemphigoid we retrospectively analysed the medical records of 30 consecutive patients with mucous membrane pemphigoid diagnosed between 2006 and 2016 at the Department of Dermatology, University Hospital Würzburg. Twenty-one patients (70%) reported symptoms indicative of oesophageal mucous membrane pemphigoid...
April 12, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29644977/emerging-optical-methods-for-endoscopic-surveillance-of-barrett-s-oesophagus
#19
REVIEW
Dale J Waterhouse, Catherine R M Fitzpatrick, Massimiliano di Pietro, Sarah E Bohndiek
Barrett's oesophagus is an acquired metaplastic condition that predisposes patients to the development of oesophageal adenocarcinoma, prompting the use of surveillance regimes to detect early malignancy for endoscopic therapy with curative intent. The currently accepted surveillance regime uses white light endoscopy together with random biopsies, but has poor sensitivity and discards information from numerous light-tissue interactions that could be exploited to probe structural, functional, and molecular changes in the tissue...
May 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29644765/correlation-between-novel-3d-high-resolution-manometry-esophagogastric-junction-metrics-and-ph-metry-in-reflux-disease-patients
#20
Y Xiao, Z Lin, Y Li, J E Pandolfino, M Chen, P J Kahrilas
BACKGROUND AND AIMS: We recently developed 2 novel 3D high-resolution manometry (HRM) metrics of esophagogastric junction (EGJ) contractility to differentiate the lower esophageal sphincter (LES) and crural diaphragm (CD) elements of EGJ pressure. This study aimed to compare these metrics to the EGJ-contractile integral (EGJ-CI) and to analyze their correlation with esophageal acid exposure time (AET) on pH-metry. METHODS: Thirty-one gastro-oesophageal reflux disease (GERD) patients and 20 control subjects underwent 24-hour pH-metry and HRM using a 3D-HRM catheter...
April 11, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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