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https://www.readbyqxmd.com/read/28231648/evaluation-of-infection-after-anterior-cruciate-ligament-reconstruction-during-a-short-period
#1
Hee-June Kim, Hyun-Joo Lee, Jong-Chul Lee, Seung-Gi Min, Hee-Soo Kyung
Purpose: We encountered 7 cases (7.1%) of infection (5 deep and 2 superficial) in 98 cases of anterior cruciate ligament (ACL) reconstruction using hamstring autografts in a 17-month period. The aim of this study was to analyze the causes of infection and to introduce our treatment strategy. Materials and Methods: We investigated the shelf-life of the fixation implants, the order of surgery, previous knee surgery, infectious pathogen, treatment of infection, and results of treatment...
March 1, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/28231634/from-endogenous-to-exogenous-pattern-formation-invasive-plant-species-changes-the-spatial-distribution-of-a-native-ant
#2
Kevin Li, Yifan He, Susanna K Campbell, A Shawn Colborn, Eliot L Jackson, Austin Martin, Ivan V Monagan, Theresa Wei Ying Ong, Ivette Perfecto
Invasive species are a significant threat to global biodiversity, but our understanding of how invasive species impact native communities across space and time remains limited. Based on observations in an old field in Southeast Michigan spanning 35 years, our study documents significant impacts of habitat change, likely driven by the invasion of the shrub, Elaeagnus umbellata, on the nest distribution patterns and population demographics of a native ant species, Formica obscuripes. Landcover change in aerial photos indicates that E...
February 23, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28231622/gingival-crevicular-fluid-levels-of-monocyte-chemoattractant-protein-mcp-1-in-patients-with-aggressive-periodontitis
#3
Sadiye Gunpinar, Nilgun Ozlem Alptekin, Niyazi Dundar
OBJECTIVES: The purpose of this study was to investigate the gingival crevicular fluid (GCF) levels of Monocyte Chemoattractant Protein (MCP)-1 in aggressive periodontitis (AgP) and whether GCF MCP-1 levels differ among localized (L) AgP and generalized (G) AgP. MATERIAL AND METHODS: A total of 160 subjects including, 80 AgP and 80 age and gender matched periodontally healthy (H) controls were recruited in this cross-sectional study (NCT02927704). GCF samples were collected from 160 patients including 50 LAgP, 30 GAgP and 80 H...
February 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28231576/molecular-markers-involved-in-tumorigenesis-of-thyroid-carcinoma-focus-on-aggressive-histotypes
#4
Gustavo C Penna, Fernanda Vaisman, Mario Vaisman, Manuel Sobrinho-Simões, Paula Soares
Thyroid cancer derived from follicular cells (TCDFC) comprises well-differentiated (papillary and follicular) carcinoma, poorly differentiated carcinoma, and anaplastic carcinoma. Papillary thyroid carcinoma is the most common endocrine cancer, and its incidence is steadily increasing. Lethality and aggressiveness of TCDFC is inversely correlated with differentiation degree. In this review, an emphasis has been put on molecular markers involved in tumorigenesis of thyroid carcinoma with a focus on aggressive histotypes and the role of such biomarkers in predicting thyroid cancer outcome...
February 24, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28231544/ginsenoside-rg3-promotes-cytotoxicity-of-paclitaxel-through-inhibiting-nf-%C3%AE%C2%BAb-signaling-and-regulating-bax-bcl-2-expression-on-triple-negative-breast-cancer
#5
Zuguo Yuan, Hao Jiang, Xinhai Zhu, Xinge Liu, Jinhui Li
Taxane-based chemotherapy regimen is the most effective therapeutic strategy for triple-negative breast cancer (TNBC) which is an aggressive subtype of breast cancer with high rate of recurrence and distant metastasis. Ginsenoside Rg3 is isolated from Panax ginseng with anti-cancer activity against carcinomas. We aim to evaluate the chemosensitizing effects of Ginsenoside Rg3 on TNBC cells and xenograft and explore the underlying mechanism. Human triple-negative breast cancer lines MDA-MB-231, MDA-MB-453 and BT-549 were used...
February 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28231541/endogenous-microrna-424-predicts-clinical-outcome-and-its-inhibition-acts-as-cancer-suppressor-in-human-non-small-cell-lung-cancer
#6
Yu Wang, Zhenyang Lv, Junfeng Fu, Ze Wang, Zhe Fan, Ting Lei
PURPOSE: We examined the expression, clinical correlation and functional mechanisms of endogenous microRNA-424 (miR-424) in human non-small cell lung cancer (NSCLC). METHODS: Expression pattern of endogenous miR-424 was examined by qRT-PCR in clinical samples obtained from 233 NSCLC patients. Correlations between differential miR-424 expression level (low vs. high) and NSCLC patients' clinicopathological parameters or survival were statistically examined. In in vitro NSCLC H596 and SW900 cells, miR-424 was either upregulated or downregulation by lentiviral transduction...
February 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28230919/maxillary-ameloblastoma-factors-associated-with-risk-of-recurrence
#7
Rong Yang, Zheqi Liu, Canbang Peng, Wei Cao, Tong Ji
BACKGROUND: Maxillary ameloblastomas are rare and associated with an aggressive course because of the anatomic composition of the maxilla and adjacent structures. The risk factors associated with recurrence were analyzed in this retrospective study. METHODS: Cases of maxillary ameloblastoma reported in a tertiary hospital from 2005 to 2015 were analyzed to identify clinicopathological and radiological factors associated with recurrence using univariate and multivariate Cox regression analyses...
February 23, 2017: Head & Neck
https://www.readbyqxmd.com/read/28230898/manifestations-and-medicolegal-significance-of-loeys-dietz-syndrome
#8
Roger W Byard
Loeys-Dietz syndrome is a recently described autosomal dominant disorder with underlying vasculopathy characterized by aortic and other vascular aneurysmal dissection/rupture. A 61-year-old man is reported who died suddenly and unexpectedly and at autopsy was found to have a ruptured abdominal aortic aneurysm. Additional findings included dolichostenomelia, high-arched palate, and pectus excavatum. There was a strong family history of Loeys-Dietz syndrome, although the decedent had never been tested. Death was, therefore, due to a ruptured abdominal aortic aneurysm in a case of probable Loeys-Dietz syndrome...
February 23, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28230800/mutilating-procedures-management-practices-and-housing-conditions-that-may-affect-the-welfare-of-farm-animals-implications-for-welfare-research
#9
Rebecca E Nordquist, Franz Josef van der Staay, Frank J C M van Eerdenburg, Francisca C Velkers, Lisa Fijn, Saskia S Arndt
A number of mutilating procedures, such as dehorning in cattle and goats and beak trimming in laying hens, are common in farm animal husbandry systems in an attempt to prevent or solve problems, such as injuries from horns or feather pecking. These procedures and other practices, such as early maternal separation, overcrowding, and barren housing conditions, raise concerns about animal welfare. Efforts to ensure or improve animal welfare involve adapting the animal to its environment, i.e., by selective breeding (e...
February 21, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/28230778/caffeic-acid-expands-anti-tumor-effect-of-metformin-in-human-metastatic-cervical-carcinoma-htb-34-cells-implications-of-ampk-activation-and-impairment-of-fatty-acids-de-novo-biosynthesis
#10
Malgorzata Tyszka-Czochara, Pawel Konieczny, Marcin Majka
The efficacy of cancer treatments is often limited and associated with substantial toxicity. Appropriate combination of drug targeting specific mechanisms may regulate metabolism of tumor cells to reduce cancer cell growth and to improve survival. Therefore, we investigated the effects of anti-diabetic drug Metformin (Met) and a natural compound caffeic acid (trans-3,4-dihydroxycinnamic acid, CA) alone and in combination to treat an aggressive metastatic human cervical HTB-34 (ATCC CRL-1550) cancer cell line...
February 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28230773/programmed-death-ligand-1-pd-l1-tumor-expression-is-associated-with-a-better-prognosis-and-diabetic-disease-in-triple-negative-breast-cancer-patients
#11
Gerardo Botti, Francesca Collina, Giosuè Scognamiglio, Federica Rao, Valentina Peluso, Rossella De Cecio, Michela Piezzo, Gabriella Landi, Michelino De Laurentiis, Monica Cantile, Maurizio Di Bonito
Triple Negative Breast Cancers (TNBC) subtype is an aggressive disease with poor clinical outcome. The only treatment available is surgery followed by chemotherapy or radiotherapy. Programmed death-ligand 1 (PD-L1) is a trans-membrane protein expressed on a wide variety of cells including immune cells, epithelial and vascular endothelial cells. Recently, PD-1/PD-L1 pathway signaling was described as an adaptive immune resistance mechanism enacted by the tumor cells to evade the immune response. Its presence on tumor cell membranes, acquired for this reason, through time, is an important prognostic value...
February 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28230749/design-of-drug-delivery-systems-containing-artemisinin-and-its-derivatives
#12
REVIEW
Blessing Atim Aderibigbe
Artemisinin and its derivatives have been reported to be experimentally effective for the treatment of highly aggressive cancers without developing drug resistance, they are useful for the treatment of malaria, other protozoal infections and they exhibit antiviral activity. However, they are limited pharmacologically by their poor bioavailability, short half-life in vivo, poor water solubility and long term usage results in toxicity. They are also expensive for the treatment of malaria when compared to other antimalarials...
February 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28230593/hemangiopericytoma-arose-from-the-site-of-meningioma-resection
#13
Xiang Wang, Xiejun Zhang, Qian Zhou, Xiuming Zhou, Lei Chen, Guodong Huang, Weiping Li
Intracranial hemangiopericytoma (HPC) is a rare tumor and accounts for 0.4% of all primary central nervous system tumors. However, it has aggressive behavior in growth and infiltration. The importance of diagnosis and treatment between HPC and meningioma cannot be overemphasized. It is rare that HPC arises from the site of benign meningioma resection. And it would be benefitted to take HPC into account when coming across a patient with meningioma "recurrence."
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28230587/everting-fracture-of-entire-frontal-bone-management-and-importance-of-preliminary-reconstruction
#14
Ken R Winston, Kathryn Beauchamp, Yasuaki Harasaki
A 34-year-old woman with severe craniofacial trauma, which included eversion of the entire frontal bone, survived with high-quality functional and cosmetic results as a consequence of efficient and aggressive action by emergency technicians and physicians. Early preliminary steps of craniofacial reconstruction provided a structural foundation that facilitated this outcome.
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28230564/attention-deficit-hyperactivity-disorder-aggression-and-illicit-stimulant-use-is-this-self-medication
#15
Annie P Odell, Grace L Reynolds, Dennis G Fisher, Loucine M Huckabay, William C Pedersen, Pamela Xandre, Milica Miočević
This study compares adults with and without attention deficit hyperactivity disorder (ADHD) on measures of direct and displaced aggression and illicit drug use. Three hundred ninety-six adults were administered the Wender Utah Rating Scale, the Risk Behavior Assessment, the Aggression Questionnaire (AQ), and the Displaced Aggression Questionnaire (DAQ). Those with ADHD were higher on all scales of the AQ and DAQ, were younger at first use of amphetamines, and were more likely to have ever used crack and amphetamines...
February 22, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28230236/a-proposal-of-post-operative-nomogram-for-overall-survival-in-patients-with-renal-cell-carcinoma-and-venous-tumor-thrombus
#16
Liangyou Gu, Zihuan Wang, Luyao Chen, Xin Ma, Hongzhao Li, Wenyuan Nie, Cheng Peng, Xintao Li, Yu Gao, Xu Zhang
OBJECTIVE: To identify the predictors of overall survival (OS) and create a post-operative prognostic model for patients with renal cell carcinoma (RCC) and venous tumor thrombus (VTT). PATIENTS AND METHODS: The study cohort included patients with RCC and VTT that underwent full surgical resection between 2006 and 2016. Univariate and multivariate analyses were used to determine the prognostic factors of OS. A nomogram was developed and internally calibrated by bootstrap resampling method...
February 23, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28229836/-fibrinolytics-in-the-treatment-of-complicated-pleural-effusions
#17
Ana Coelho, Margarida Coelho, Joana Pereira, Vasco Lavrador, Lurdes Morais, Fátima Carvalho
INTRODUCTION: The treatment of complicated pleural parapneumonic effusions with intrapleural instillation of fibrinolytics, has shown similar results as surgical treatment. The present study aimed to evaluate the results of the use of intrapleural instillation of fibrinolytics in the treatment of complicated pleural parapneumonic effusions, in patients followed in our hospital. MATERIAL AND METHODS: A retrospective review of all the patients (aged between one month and 18 years) diagnosed with complicated parapneumonic effusions, which had chest drain insertion with intrapleural instillation of fibrinolytic, between January 2005 and December 2013, was undertaken...
November 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28229621/caveolin-1-expression-favors-tumor-growth-and-is-associated-with-poor-survival-in-primary-lung-adenocarcinomas
#18
Eleonora Duregon, Rebecca Senetta, Luca Bertero, Benedetta Bussolati, Laura Annaratone, Alessandra Pittaro, Mauro Papotti, Caterina Marchiò, Paola Cassoni
Despite the consolidated clinico-pathological correlates of Caveolin 1 expression in non-small cell lung cancer, the available data on the role of Caveolin 1 in relation to proliferation, migration, and metastasis in lung adenocarcinoma cells is still scant. Here, we aimed to confirm whether Caveolin 1 may act as a promoter of cell growth in human lung adenocarcinoma using in vitro and in vivo models, supported by a survival analysis of Caveolin 1 expression in a series of 116 primary lung adenocarcinomas. The silencing of endogenous Caveolin 1 expression in H522 lung adenocarcinoma cells through stable shRNA transfection significantly inhibited cellular proliferation in vitro and in vivo, in a lung adenocarcinoma xenograft mouse model...
February 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28229434/preclinical-pharmacokinetics-and-pharmacodynamics-of-pinometostat-epz-5676-a-first-in-class-small-molecule-s-adenosyl-methionine-competitive-inhibitor-of-dot1l
#19
Nigel J Waters
Acute leukemias bearing mixed lineage leukemia (MLL) rearrangements are aggressive diseases characterized by a poor overall prognosis despite multi-agent chemotherapy. Aberrant fusion proteins involving the MLL histone methyltransferase (HMT) lead to recruitment of DOT1L, to a multi-protein complex resulting in aberrant methylation of histone H3 lysine 79 at MLL target genes, and ultimately enhanced expression of critical genes for hematopoietic differentiation, including HOXA9 and MEIS1, and as such defines the established mechanism for leukemogenesis in MLL-rearrangement (MLL-r) leukemias...
February 22, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28229364/molecular-subtyping-in-diffuse-large-b-cell-lymphoma-closer-to-an-approach-of-precision-therapy
#20
REVIEW
Reem Karmali, Leo I Gordon
It has become clear that there is immense biological heterogeneity in diffuse large B cell lymphoma (DLBCL). Developing technology has allowed better characterization of patient subsets at a molecular level, allowing for a link of phenotype and clinical outcomes to oncogenic mechanisms and biologic signatures. Cell of origin and double hit status are able to identify aggressive subsets, with molecular profiling allowing for a clearer understanding of biologic pathways that contribute to cellular resistance to conventional treatment in these subsets...
February 2017: Current Treatment Options in Oncology
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