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https://www.readbyqxmd.com/read/29684818/glut1-protects-prostate-cancer-cells-from-glucose-deprivation-induced-oxidative-stress
#1
Pedro Gonzalez-Menendez, David Hevia, Rebeca Alonso-Arias, Alejandro Alvarez-Artime, Aida Rodriguez-Garcia, Sandrina Kinet, Ivan Gonzalez-Pola, Naomi Taylor, Juan C Mayo, Rosa M Sainz
Glucose, chief metabolic support for cancer cell survival and growth, is mainly imported into cells by facilitated glucose transporters (GLUTs). The increase in glucose uptake along with tumor progression is due to an increment of facilitative glucose transporters as GLUT1. GLUT1 prevents cell death of cancer cells caused by growth factors deprivation, but there is scarce information about its role on the damage caused by glucose deprivation, which usually occurs within the core of a growing tumor. In prostate cancer (PCa), GLUT1 is found in the most aggressive tumors, and it is regulated by androgens...
April 12, 2018: Redox Biology
https://www.readbyqxmd.com/read/29684626/multi-scale-structural-design-and-biomechanics-of-the-pistol-shrimp-snapper-claw
#2
Shahrouz Amini, Maryam Tadayon, J Q Isaiah Chua, Ali Miserez
The Arthropoda, the largest phylum of the Animal Kingdom, have successfully evolved to survive various ecological constraints under a wide range of environmental conditions. Central to this survival are the structural designs developed in their exoskeletons and their raptorial appendages for protection and hunting. One such example, the pistol shrimp, is a shallow-water crustacean that is well-known for its aggressive hunting behavior, using its snapper claw to trigger the nucleation of cavitation bubbles that strike targets...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29684339/sorafenib-induced-tumor-lysis-syndrome-in-a-patient-with-metastatic-hepatocellular-carcinoma
#3
Sardar Zakariya Imam, Mohammad Faizan Zahid, Muhammad Asad Maqbool
Tumor lysis syndrome is a potentially lethal complication of chemotherapy, usually associated with aggressive hematologic malignancies. We describe the case of a young patient with metastatic hepatocellular cancer who developed rapid and fatal tumor lysis syndrome following initiation of sorafenib therapy. Although rare with sorafenib therapy for hepatocellular carcinoma, tumor lysis syndrome is serious complication. Patients with a high burden of disease at therapy initiation should have their metabolic parameters measured prior to starting therapy and closely followed for the first 1-2 weeks while being treated...
April 17, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29684225/primary-intraocular-malignant-rhabdoid-tumor-without-extrascleral-compromise
#4
Eva Ayala Barroso, Alejandra Tapia Bahamondes, Juan Carlos Sánchez España, Llúcia Alós, Ramón Medel Jiménez
Primary intraocular malignant rhabdoid tumor is classified as a malignant extrarenal rhabdoid tumor. It is extremely rare, highly aggressive, and, so far, only one case (in a newborn) has been described in the medical literature. The authors report a second case of primary intraocular malignant rhabdoid tumor, this time without extrascleral involvement and in a teenager, and describe its histological, immunohistochemical, and radiological characteristics along with clinical correlations. [J Pediatr Ophthalmol...
April 23, 2018: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29683931/value-of-18f-fdg-pet-ct-imaging-in-the-staging-restaging-monitoring-of-response-to-therapy-and-surveillance-of-uterine-leiomyosarcomas
#5
Ophélie Bélissant, Laurence Champion, Hind Thevenet, Pierre Weinmann, Jean-Louis Alberini
OBJECTIVE: Leiomyosarcoma (LMS) is the most common subtype of uterine sarcomas. It is a rare and aggressive tumour. The aim of the present study was to assess the performance of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT imaging in four clinical settings: initial staging, restaging, monitoring of response to therapy and post-therapy surveillance of uterine LMS. PATIENTS AND METHODS: A bicentric retrospective study was carried out on a group of 21 patients with uterine LMS for whom a total of 52 PET/CT scans were available in initial staging (n=11), restaging (n=11), monitoring of response to therapy (n=17) and post-therapy surveillance (n=13)...
April 20, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29683892/implication-of-highly-cytotoxic-natural-killer-cells-for-esophageal-squamous-cell-carcinoma-treatment
#6
Kee Siang Lim, Kosaku Mimura, Ley-Fang Kua, Kensuke Shiraishi, Koji Kono
Esophageal squamous cell carcinoma (ESCC) is an aggressive upper gastrointestinal cancer and effective treatments are limited. Previous studies reported that natural killer (NK) cells expanded by coculturing with K562-mb15-41BBL feeder cells, a genetically modified K562 leukemia cell line that expresses membrane-bound interleukin (IL)-15 and 41BBL ligand, were highly proliferative and highly cytotoxic. Here, we investigated the potential of expanded NK cells for ESCC treatment. We analyzed both genetic and surface expression levels of NKG2D ligands (NKG2DLs) in ESCC using publicly available microarray data sets and ESCC cell lines...
April 20, 2018: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29683891/il-21-increases-the-reactivity-of-allogeneic-human-v%C3%AE-9v%C3%AE-2-t-cells-against-primary-glioblastoma-tumors
#7
Noémie Joalland, Cynthia Chauvin, Lisa Oliver, François M Vallette, Claire Pecqueur, Ulrich Jarry, Emmanuel Scotet
Glioblastoma multiforme (GBM) remains the most frequent and deadliest primary brain tumor in adults despite aggressive treatments, because of the persistence of infiltrative and resistant tumor cells. Nonalloreactive human Vγ9Vδ2 T lymphocytes, the major peripheral γδ T-cell subset in adults, represent attractive effectors for designing immunotherapeutic strategies to track and eliminate brain tumor cells, with limited side effects. We analyzed the effects of ex vivo sensitizations of Vγ9Vδ2 T cells by IL-21, a modulating cytokine, on their cytolytic reactivity...
April 20, 2018: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29683880/economic-analysis-of-neoadjuvant-chemotherapy-versus-primary-debulking-surgery-for-advanced-epithelial-ovarian-cancer-using-an-aggressive-surgical-paradigm
#8
Ashley L Cole, Emma L Barber, Anagha Gogate, Arthur-Quan Tran, Stephanie B Wheeler
OBJECTIVES: Neoadjuvant chemotherapy (NACT) versus primary debulking surgery (PDS) for advanced epithelial ovarian cancer (AEOC) remains controversial in the United States. Generalizability of existing trial results has been criticized because of less aggressive debulking procedures than commonly used in the United States. As a result, economic evaluations using input data from these trials may not accurately reflect costs and outcomes associated with more aggressive primary surgery. Using data from an ongoing trial performing aggressive debulking, we investigated the cost-effectiveness and cost-utility of NACT versus PDS for AEOC...
April 21, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29683815/salivary-secretory-carcinoma-with-a-novel-etv6-met-fusion-expanding-the-molecular-spectrum-of-a-recently-described-entity
#9
Lisa M Rooper, Theodoros Karantanos, Yi Ning, Justin A Bishop, Sarah W Gordon, Hyunseok Kang
Secretory carcinoma of the salivary glands, also known as mammary analogue secretory carcinoma, is a recently described tumor characterized by generally indolent clinical behavior and recurrent ETV6-NTRK3 fusions. However, a small subset of recent cases with high-grade histology, aggressive behavior, or alternate molecular findings are expanding the spectrum of this entity. In this case, a 59-year-old female presented with an infiltrative submandibular gland tumor that was originally classified as a high-grade acinic cell carcinoma, papillary-cystic variant...
April 20, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29683691/veterans-with-recent-substance-use-and-aggression-ptsd-substance-use-and-social-network-behaviors
#10
Minden B Sexton, Alan K Davis, Katherine R Buchholz, Jamie J Winters, Sheila A M Rauch, Maegan Yzquibell, Erin E Bonar, Steven Friday, Stephen T Chermack
OBJECTIVE: Violence is a salient concern among veterans, yet relationships between psychiatric comorbidity, social networks, and aggression are poorly understood. We examined associations between biopsychosocial factors (substance use, posttraumatic stress disorder [PTSD], and social network behaviors) with aggression. METHOD: We recruited veterans endorsing past-year aggression and substance use (N = 180) from Department of Veterans Affairs outpatient treatment clinics...
April 23, 2018: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29683291/daylight-pdt-for-field-cancerization-lessons-from-molecular-biology
#11
Max Rybarski, Lutz Schmitz, Ben Novak, Thomas Dirschka
Actinic keratoses (AKs) represent in-situ squamous cell carcinomas that potentially invade subepidermal structures and may metastasize. Until now, it is unpredictable to determine which AK lesions show this aggressive behaviour. As AKs usually occur in large sun exposed areas, field-directed treatments have become the standard treatment regimen. Among these, conventional photodynamic therapy (cPDT) with 5- aminolaevulinic acid (ALA) or methyl-aminolevulinate (MAL) using red light is particularly effective in the treatment of AKs, but acceptance of the therapy is impaired by severe pain during treatment...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29683097/dtcm-glutarimide-delays-growth-and-radiosensitizes-glioblastoma
#12
Gabriela Molinari Roberto, Helder Henrique Paiva, Lucas Eduardo Botelho de Souza, Julia Alejandra Pezuk, Gabriela Maciel Vieira, Harley Francisco de Oliveira, Kazuo Umezawa, Luiz Gonzaga Tone, Maria Sol Brassesco
BACKGROUND AND PURPOSE: Glioblastoma (GBM) is the most aggressive brain tumor. Even with the advent of temozolomide, patient survival remains poor, with expected median survival around 1 year from diagnosis. Consequently, the relentless search for new therapeutic strategies able to increase patient outcome persists. 3-[(dodecylthiocarbonyl) methyl] glutarimide (DTCM-g) is a new anti-inflammatory compound that already showed antitumor effects. MATERIAL AND METHODS: Clonogenic survival, proliferation, apoptosis, cell cycle progression and invasion capacity of pediatric and adult GBM cell lines (U87MG, U251MG, SF188 and KNS-42) were evaluated under treatment with DTCM-g...
April 22, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29683077/workplace-psychological-aggression-job-stress-and-vigor-a-test-of-longitudinal-effects
#13
Omer Farooq Malik, Aaron C H Schat, Asif Shahzad, Muhammad Mustafa Raziq, Rafia Faiz
The purpose of this research was to examine the relationships between supervisor- and customer-initiated psychological aggression and vigor across time, and to determine the mediating role of job stress in these relationships. We also investigated the potential for differential impacts of supervisor and customer aggression on our outcome variables. A two-wave longitudinal study was conducted with a time lag of 6 months. The study sample consisted of 215 branch office employees of five large commercial banks situated in Islamabad, Pakistan...
April 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29683076/lifetime-victimization-in-children-and-adolescents-with-adhd
#14
Jorge Aguado-Gracia, Pilar Mundo-Cid, Fernando Lopez-Seco, Silvia Acosta-García, María José Cortes-Ruiz, Elisabet Vilella, Adela Masana-Marín
The objective of this study is to describe the frequency and type of victimization in a Spanish child and adolescent clinical ADHD sample and to analyze the association between the types of victimization and the severity of the symptoms. The sample is composed of 106 outpatients in treatment for ADHD, according to Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) criteria. Symptom severity was measured by the Conners-3 scales. ADHD and comorbid diagnostics were evaluated with the Mini-Kid interview...
April 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29682976/disentangling-the-cycle-potential-mediators-and-moderators-in-the-intergenerational-transmission-of-parent-child-aggression
#15
Christina M Rodriguez, Paul J Silvia, Samantha Gonzalez, Maria-Ernestina Christl
Although a cycle of harsh and abusive parenting has been recognized for decades, this cycle is not inevitable. Indeed, the mechanisms underlying such patterns, and the resources parents may access to disrupt this cycle, require further study. Research investigating those processes has either relied on cross-sectional designs or largely assessed mediators or moderators at one time point. The current investigation of parent-child aggression (PCA) risk utilized a longitudinal design to consider possible mediators and moderators across three time points...
January 1, 2018: Child Maltreatment
https://www.readbyqxmd.com/read/29682886/a-common-regulatory-variant-in-slc35b4-influences-the-recurrence-and-survival-of-prostate-cancer
#16
Eric Y Huang, Yu-Jia Chang, Shu-Pin Huang, Victor C Lin, Chia-Cheng Yu, Chao-Yuan Huang, Hsin-Ling Yin, Ta-Yuan Chang, Te-Ling Lu, Bo-Ying Bao
Single nucleotide polymorphisms (SNPs) within the regulatory elements of a gene can alter gene expression, making these SNPs of prime importance for candidate gene association studies. We aimed to determine whether such regulatory variants are associated with clinical outcomes in three cohorts of patients with prostate cancer. We used RegulomeDB to identify potential regulatory variants based on in silico predictions and reviewed genome-wide experimental findings. Overall, 131 putative regulatory SNPs with the highest confidence score on predicted functionality were investigated in two independent localized prostate cancer cohorts totalling 458 patients who underwent radical prostatectomy...
April 23, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29682757/infrared-lasers-for-the-treatment-of-moderate-to-severe-periodontitis-an-american-academy-of-periodontology-best-evidence-review
#17
Leandro Chambrone, Umberto D Ramos, Mark A Reynolds
OBJECTIVE: This systematic review assesses the efficacy of infrared laser therapy used alone or as an adjunct to nonsurgical or surgical periodontal therapy, on clinical and patient-centered outcomes in patients with periodontitis. METHODS: Randomized clinical trials (RCTs) with a follow-up duration ≥ 3 months that evaluated root surface debridement (i.e., scaling and root debridement with or without surgical access) to laser therapy alone or laser therapy plus root surface debridement for the treatment of adult patients (≥18 years old) with moderate to severe aggressive or chronic periodontitis were considered eligible for inclusion...
April 22, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29682708/-early-diagnosis-and-treatment-of-anastomotic-leak-after-rectal-cancer-surgery
#18
Tinghan Yang, Ziqiang Wang
Anastomotic leakage is the most common major complication after mid-low rectal cancer surgery. Due to lack of knowledge regarding the virtual mechanisms of anastomotic leakage, not much can be done to prevent its development. The aim of the present review was to discuss the prevention, early diagnosis, and treatment of anastomotic leakage after rectal cancer surgery. For patients with risk factors, such as anastomotic site within 4 cm from anus, obese men, lack of blood supply of the anastomotic site, neoadjuvant chemo radiotherapy, or patients with severe co-morbidity, aggressive preventive strategy should be adopted...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29682673/sociability-in-fruit-flies-genetic-variation-heritability-and-plasticity
#19
Andrew M Scott, Ian Dworkin, Reuven Dukas
Sociability, defined as individuals' propensity to participate in non-aggressive activities with conspecifics, is a fundamental feature of behavior in many animals including humans. However, we still have a limited knowledge of the mechanisms and evolutionary biology of sociability. To enhance our understanding, we developed a new protocol to quantify sociability in fruit flies (Drosophila melanogaster). In a series of experiments with 59 F1 hybrids derived from inbred lines, we documented, first, significant genetic variation in sociability in both males and females, with broad-sense heritabilities of 0...
April 23, 2018: Behavior Genetics
https://www.readbyqxmd.com/read/29682632/an-alpine-ant-s-behavioural-polymorphism-monogyny-with-and-without-internest-aggression-in-tetramorium-alpestre
#20
Patrick Krapf, Lucia Russo, Wolfgang Arthofer, Markus Möst, Florian M Steiner, Birgit C Schlick-Steiner
Social structure influences animal societies on various levels (e.g., relatedness, behaviour). In ants, both the number of matings per queen and the number of queens per colony can vary strongly. While workers from both monogynous and polygynous colonies often fight fiercely, in supercolonies (an extreme form of polygyny comprising thousands of queens in spatially separated but interconnected nests), non-nestmates interact peacefully. Studies on social and behavioural polymorphism within ant species can help elucidate their influence on genetic diversity and behaviour and the factors triggering variation in social structure and behaviour...
2018: Ethology, Ecology & Evolution
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