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bladder tissue engineering

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https://www.readbyqxmd.com/read/28915233/the-utility-of-stem-cells-in-pediatric-urinary-bladder-regeneration
#1
REVIEW
Philip M Iannaccone, Vasil Galat, Matthew I Bury, Yongchao C Ma, Arun K Sharma
Pediatric patients with a neurogenic urinary bladder caused by developmental abnormalities including spina bifida exhibit chronic urological problems. Surgical management in the form of enterocystoplasty is used to enlarge the bladder but is associated with significant clinical complications. Thus, alternative methods to enterocystoplasty have been explored through the incorporation of stem cells with tissue engineering strategies. Within the context of this review, we will examine the use of bone marrow stem cells and induced pluripotent stem cells (iPSCs) as they relate to bladder regeneration at the anatomic and molecular levels...
September 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28888113/tissue-engineered-human-3d-model-of-bladder-cancer-for-invasion-study-and-drug-discovery
#2
Cassandra Ringuette Goulet, Geneviève Bernard, Stéphane Chabaud, Amélie Couture, Alexandre Langlois, Bertrand Neveu, Frédéric Pouliot, Stéphane Bolduc
The tumour microenvironment is critical to both the initiation and maintenance of tumorigenesis. Reconstitution of the microenvironment is a major challenge for in vitro cancer models. Indeed, conventional 2D culture systems cannot replicate the complexity, diversity and dynamic nature of the tumour microenvironment. In this study, we have developed a 3D endotheliazed vesical equivalent by using tissue engineering from primary human cells in which non-invasive or invasive bladder cancer (BCa) cell lines, cultured as compact spheroids, were incorporated...
August 29, 2017: Biomaterials
https://www.readbyqxmd.com/read/28811169/tissue-engineered-extracellular-matrices-ecms-in-urology-evolution-and-future-directions
#3
REVIEW
N F Davis, E M Cunnane, F J O'Brien, J J Mulvihill, M T Walsh
Autologous gastrointestinal tissue has remained the gold-standard reconstructive biomaterial in urology for >100 years. Mucus-secreting epithelium is associated with lifelong metabolic and neuromechanical complications when implanted into the urinary tract. Therefore, the availability of biocompatible tissue-engineered biomaterials such as extracellular matrix (ECM) scaffolds may provide an attractive alternative for urologists. ECMs are decellularised, biodegradable membranes that have shown promise for repairing defective urinary tract segments in vitro and in vivo by inducing a host-derived tissue remodelling response after implantation...
August 12, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28750602/mechanical-induction-of-bi-directional-orientation-of-primary-porcine-bladder-smooth-muscle-cells-in-tubular-fibrin-poly-vinylidene-fluoride-scaffolds-for-ureteral-and-urethral-repair-using-cyclic-and-focal-balloon-catheter-stimulation
#4
Volker Seifarth, Joachim O Grosse, Matthias Gossmann, Heinz Peter Janke, Patrick Arndt, Sabine Koch, Matthias Epple, Gerhard M Artmann, Aysegül Temiz Artmann
To restore damaged organ function or to investigate organ mechanisms, it is necessary to prepare replicates that follow the biological role model as faithfully as possible. The interdisciplinary field of tissue engineering has great potential in regenerative medicine and might overcome negative side effects in the replacement of damaged organs. In particular, tubular organ structures of the genitourinary tract, such as the ureter and urethra, are challenging because of their complexity and special milieu that gives rise to incrustation, inflammation and stricture formation...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28660185/dedifferentiated-chondrocytes-in-composite-microfibers-as-tool-for-cartilage-repair
#5
Marco Angelozzi, Letizia Penolazzi, Stefania Mazzitelli, Elisabetta Lambertini, Andrea Lolli, Roberta Piva, Claudio Nastruzzi
Tissue engineering (TE) approaches using biomaterials have gain important roles in the regeneration of cartilage. This paper describes the production by microfluidics of alginate-based microfibers containing both extracellular matrix (ECM)-derived biomaterials and chondrocytes. As ECM components gelatin or decellularized urinary bladder matrix (UBM) were investigated. The effectiveness of the composite microfibers has been tested to modulate the behavior and redifferentiation of dedifferentiated chondrocytes...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28631918/-using-of-cell-biocomposite-material-in-tissue-engineering-of-the-urinary-bladder
#6
P V Glybochko, Yu V Olefir, Yu G Alyaev, D V Butnaru, E A Bezrukov, A A Chaplenko, T M Zharikova
In a systematic review, to present an overview of the current situation in the field of tissue engineering of urinary bladder related to the use of cell lines pre-cultured on matrices. The selection of eligible publications was conducted according to the method described in the article Glybochko P.V. et al. "Tissue engineering of urinary bladder using acellular matrix." At the final stage, studies investigating the application of matrices with human and animal cell lines were analyzed. Contemporary approaches to using cell-based tissue engineering of the bladder were analyzed, including the formation of 3D structures from several types of cells, cell layers and genetic modification of injected cells...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28606777/the-clinical-outcomes-of-vaginoplasty-using-tissue-engineered-biomaterial-mesh-in-patients-with-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome
#7
Xiaoli Zhang, Zhongyu Liu, Yizhuo Yang, Yuanqing Yao, Ye Tao
OBJECTIVE: The aim of the study is to evaluate the clinical outcomes of vaginoplasty using tissue-engineered biomaterial mesh in the patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. PATIENTS AND METHODS: Patients with MRKH syndrome underwent the vaginoplasty using tissue-engineered biomaterial mesh between January 2006 and August 2014 in PLA general hospital. We analyzed the anatomic results and collected the standardized FSFI (Female Sexual Function Index) questionnaire from each patient...
June 10, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28578271/a-gold-nanoparticle-coated-porcine-cholecyst-derived-bioscaffold-for-cardiac-tissue-engineering
#8
Reshma S Nair, Jimna Mohamed Ameer, Malcolm R Alison, Thapasimuthu V Anilkumar
Extracellular matrices of xenogeneic origin have been extensively used for biomedical applications, despite the possibility of heterogeneity in structure. Surface modification of biologically derived biomaterials using nanoparticles is an emerging strategy for improving topographical homogeneity when employing these scaffolds for sophisticated tissue engineering applications. Recently, as a tissue engineering scaffold, cholecyst derived extracellular matrix (C-ECM) has been shown to have several advantages over extracellular matrices derived from other organs such as jejunum and urinary bladder...
September 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28532019/characterization-of-bladder-acellular-matrix-hydrogel-with-inherent-bioactive-factors
#9
Dan Jiang, Jianwen Huang, Huili Shao, Xuechao Hu, Lujie Song, Yaopeng Zhang
Bladder acellular matrix (BAM) hydrogel may have great potential in tissue engineering due to outstanding biocompatibility and the presence of inherent bioactive factors in BAM. In this study, we prepared the BAM hydrogel by the method of enzymatic solubilization with pepsin and characterize the microrheological properties of the BAM precursor solution. The structures of the BAM hydrogel were characterized by scanning electron microscope (SEM), Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28513058/pro-myogenic-and-low-oxygen-culture-increases-expression-of-contractile-smooth-muscle-markers-in-human-fibroblasts
#10
Matija Veber, David Dolivo, Marsha Rolle, Tanja Dominko
Smooth muscle cells are essential for tissue engineering strategies to fabricate organs such as blood vessels, esophagus, and bladder, and to create disease models of these systems. In order for such therapies and models to be feasible, smooth muscle cells must be sourced effectively to enable production of large numbers of functional cells. In vitro, smooth muscle cells divide slowly and demonstrate short proliferative lifespans compared to other types of cells including stem cells and fibroblasts, limiting the number of cells that can be derived from expansion in culture of a primary isolation...
May 17, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28453558/tumor-targeted-sn38-inhibits-growth-of-early-stage-non-small-cell-lung-cancer-nsclc-in-a-kras-p53-transgenic-mouse-model
#11
Alexander Y Deneka, Leora Haber, Meghan C Kopp, Anna V Gaponova, Anna S Nikonova, Erica A Golemis
Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide, with a 5-year survival of only ~16%. Potential strategies to address NSCLC mortality include improvements in early detection and prevention, and development of new therapies suitable for use in patients with early and late stage diagnoses. Controlling the growth of early stage tumors could yield significant clinical benefits for patients with comorbidities that make them poor candidates for surgery: however, many drugs that limit cancer growth are not useful in the setting of long-term use or in comorbid patients, because of associated toxicities...
2017: PloS One
https://www.readbyqxmd.com/read/28446009/applications-of-microfluidic-devices-for-urology
#12
REVIEW
Se Jik Han, Hun-Kuk Park, Kyung Sook Kim
Microfluidics is considered an important technology that is suitable for numerous biomedical applications, including cancer diagnosis, metastasis, drug delivery, and tissue engineering. Although microfluidics is still considered to be a new approach in urological research, several pioneering studies have been reported in recent years. In this paper, we reviewed urological research works using microfluidic devices. Microfluidic devices were used for the detection of prostate and bladder cancer and the characterization of cancer microenvironments...
April 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28415542/bladder-smooth-muscle-cells-on-electrospun-poly-%C3%AE%C2%B5-caprolactone-poly-l-lactic-acid-scaffold-promote-bladder-regeneration-in-a-canine-model
#13
Nasser Shakhssalim, Masoud Soleimani, Mohammad M Dehghan, Javad Rasouli, Masoud Taghizadeh-Jahed, Peyman M Torbati, Mohammad Naji
Engineering of urinary bladder has been the focus of numerous studies in recent decade. Novel biomaterials, innovative fabrication methods and various modification processes of scaffolds are the critical issues to find supportive matrices. Supportive characteristics of electrospun PCL/PLLA nano-scaffold for bladder augmentation in canine model and the role of bladder cells in regeneration process were appraised. Electrospun PCL/PLLA was fabricated by co-electrospinning of PCL and PLLA. Bladder cells were isolated and transduced with lentiviral particles encoding eGFP and JRed proteins...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28394530/-tissue-engineering-of-urinary-bladder-using-acellular-matrix
#14
P V Glybochko, Yu V Olefir, Yu G Alyaev, D V Butnaru, E A Bezrukov, A A Chaplenko, T M Zharikova
INTRODUCTION: Tissue engineering has become a new promising strategy for repairing damaged organs of the urinary system, including the bladder. The basic idea of tissue engineering is to integrate cellular technology and advanced bio-compatible materials to replace or repair tissues and organs. AIM: of the study is the objective reflection of the current trends and advances in tissue engineering of the bladder using acellular matrix through a systematic search of preclinical and clinical studies of interest...
April 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28322621/bladder-regeneration-using-multiple-acellular-scaffolds-with-growth-factors-in-a-bladder
#15
Luc A J Roelofs, Paul K J D de Jonge, Egbert Oosterwijk, Dorien M Tiemessen, Barbara B M Kortmann, Robert P E de Gier, Elly M M Versteeg, Willeke F Daamen, Toin H van Kuppevelt, Paul J Geutjes, Wout F J Feitz
INTRODUCTION: Tissue engineering may become an alternative to current bladder augmentation techniques. Large scaffolds are needed for clinically significant augmentation, but can result in fibrosis and graft shrinkage. The purpose of this study was to investigate the use of multiple scaffolds instead of one large scaffold, to enhance bladder tissue regeneration and bladder capacity. Second, acellular collagen, collagen-heparin, and collagen-heparin scaffolds with growth factors (GFs) were used and the biological activity of the different scaffolds was compared in a large animal model...
May 2, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28315439/interaction-of-chitin-chitosan-with-salivary-and-other-epithelial-cells-an-overview
#16
REVIEW
Sharvari Vijaykumar Patil, Lalitha S Y Nanduri
Chitin and its deacetylated form, chitosan, have been widely used for tissue engineering of both epithelial and mesenchymal tissues. Epithelial cells characterised by their sheet-like tight cellular arrangement and polarised nature, constitute a major component in various organs and play a variety of roles including protection, secretion and maintenance of tissue homeostasis. Regeneration of damaged epithelial tissues has been studied using biomaterials such as chitin, chitosan, hyaluronan, gelatin and alginate...
March 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28248041/-urinary-bladder-substitution-using-combined-membrane-based-on-secretions-of-human-mesenchymal-stem-cells-and-type-i-collagen
#17
V I Kirpatovckii, D M Kamalov, A Yu Efimenko, P I Makarevich, G D Sagaradze, O A Makarevich, P P Nimiritskii, E O Osidak, S P Domogatskii, V K Karpov, Z H A Akopyan, V A Tkachuk, A A Kamalov
AIM: Despite the widespread use of intestinal cystoplasty, urinary bladder substitution remains a challenging problem due to the complexity of operations and the potentially high risk of complications. A promising alternative may be bio-engineered collagen-based matrices containing stem cells or their secretions. MATERIAL AND METHODS: To evaluate the effectiveness of this bladder substitution modality, an experiment was conducted on 14 male rabbits. The animals underwent resection of urinary bladder, and the formed defect was substituted with a membrane of type I collagen (series 1, 5 rabbits) or a membrane of the same composition containing a conditioned medium with secretion of mesenchymal stem/stromal cells derived from human adipose tissue (series 2, 5 rabbits)...
December 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28229212/the-effect-of-a-cyclic-uniaxial-strain-on-urinary-bladder-cells
#18
Dorien Tiemessen, Paul de Jonge, Willeke Daamen, Wout Feitz, Paul Geutjes, Egbert Oosterwijk
PURPOSE: Pre-conditioning of a cell seeded construct may improve the functional outcome of a tissue engineered construct for augmentation cystoplasty. The precise effects of mechanical stimulation on urinary bladder cells in vitro are not clear. In this study we investigate the effect of a cyclic uniaxial strain culture on urinary bladder cells which were seeded on a type I collagen scaffold. METHODS: Isolated porcine smooth muscle cells or urothelial cells were seeded on a type I collagen scaffolds and cultured under static and dynamic conditions...
February 23, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28196288/clinical-adequacy-assessment-of-autocontours-for-prostate-imrt-with-meaningful-endpoints
#19
Hamidreza Nourzadeh, William T Watkins, Mahmoud Ahmed, Cheukkai Hui, David Schlesinger, Jeffrey V Siebers
PURPOSE: To determine if radiation treatment plans created based on autosegmented (AS) regions-of-interest (ROI)s are clinically equivalent to plans created based on manually segmented ROIs, where equivalence is evaluated using probabilistic dosimetric metrics and probabilistic biological endpoints for prostate IMRT. METHOD AND MATERIALS: Manually drawn contours and autosegmented ROIs were created for 167 CT image sets acquired from 19 prostate patients. Autosegmentation was performed utilizing Pinnacle's Smart Probabilistic Image Contouring Engine...
April 2017: Medical Physics
https://www.readbyqxmd.com/read/28162053/cell-and-growth-factor-loaded-keratin-hydrogels-for-treatment-of-volumetric-muscle-loss-in-a-mouse-model
#20
H B Baker, J A Passipieri, Mevan Siriwardane, Mary D Ellenburg, Manasi Vadhavkar, Christopher R Bergman, Justin M Saul, Seth Tomblyn, Luke Burnett, George J Christ
Wounds to the head, neck, and extremities have been estimated to account for ∼84% of reported combat injuries to military personnel. Volumetric muscle loss (VML), defined as skeletal muscle injuries in which tissue loss results in permanent functional impairment, is common among these injuries. The present standard of care entails the use of muscle flap transfers, which suffer from the need for additional surgery when using autografts or the risk of rejection when cadaveric grafts are used. Tissue engineering (TE) strategies for skeletal muscle repair have been investigated as a means to overcome current therapeutic limitations...
April 14, 2017: Tissue Engineering. Part A
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