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https://www.readbyqxmd.com/read/28103243/the-socioeconomic-benefit-to-individuals-of-achieving-the-2020-targets-for-five-preventive-chemotherapy-neglected-tropical-diseases
#1
William K Redekop, Edeltraud J Lenk, Marianne Luyendijk, Christopher Fitzpatrick, Louis Niessen, Wilma A Stolk, Fabrizio Tediosi, Adriana J Rijnsburger, Roel Bakker, Jan A C Hontelez, Jan H Richardus, Julie Jacobson, Sake J de Vlas, Johan L Severens
BACKGROUND: Lymphatic filariasis (LF), onchocerciasis, schistosomiasis, soil-transmitted helminths (STH) and trachoma represent the five most prevalent neglected tropical diseases (NTDs). They can be controlled or eliminated by means of safe and cost-effective interventions delivered through programs of Mass Drug Administration (MDA)-also named Preventive Chemotherapy (PCT). The WHO defined targets for NTD control/elimination by 2020, reinforced by the 2012 London Declaration, which, if achieved, would result in dramatic health gains...
January 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28100460/making-a-song-and-dance-about-trachoma
#2
Richard Hurley
No abstract text is available yet for this article.
January 18, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28099433/defining-seropositivity-thresholds-for-use-in-trachoma-elimination-studies
#3
Stephanie J Migchelsen, Diana L Martin, Khamphoua Southisombath, Patrick Turyaguma, Anne Heggen, Peter Paul Rubangakene, Hassan Joof, Pateh Makalo, Gretchen Cooley, Sarah Gwyn, Anthony W Solomon, Martin J Holland, Paul Courtright, Rebecca Willis, Neal D E Alexander, David C W Mabey, Chrissy H Roberts
BACKGROUND: Efforts are underway to eliminate trachoma as a public health problem by 2020. Programmatic guidelines are based on clinical signs that correlate poorly with Chlamydia trachomatis (Ct) infection in post-treatment and low-endemicity settings. Age-specific seroprevalence of anti Ct Pgp3 antibodies has been proposed as an alternative indicator of the need for intervention. To standardise the use of these tools, it is necessary to develop an analytical approach that performs reproducibly both within and between studies...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28089329/in-morocco-the-elimination-of-trachoma-as-a-public-health-problem-becomes-a-reality
#4
Jaouad Hammou, Houda El Ajaroumi, Hassan Hasbi, Ahmed Nakhlaoui, Abderrahim Hmadna, Abderahmane El Maaroufi
No abstract text is available yet for this article.
January 11, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28065724/epidemiology-of-dry-eye-disease-in-africa-the-sparse-information-gaps-and-opportunities
#5
REVIEW
A E Osae, U Gehlsen, J Horstmann, S Siebelmann, M E Stern, D B Kumah, P Steven
Dry eye disease (DED) is an increasingly significant clinical problem in developing countries and/or emerging economies. Existing studies on DED conducted in these areas have largely reported on associations between DED and infectious disease (trachoma) and malnutrition (hypovitaminosis A), but current trends of industrialization, urbanization, and modernization in these areas could result in a shift to other forms of DED. Herein, we review the epidemiology of DED in these geographic areas, highlighting potential causes and risk factors of DED while presenting information on diagnostic tools and algorithms and insight into some treatment modalities of DED that could prove useful to clinicians and investigators in these regions...
January 5, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28054225/spectrum-and-burden-of-neglected-tropical-diseases-observed-in-an-infectious-and-tropical-diseases-unit-in-florence-italy-2000-2015
#6
Lorenzo Zammarchi, Iacopo Vellere, Leonardo Stella, Filippo Bartalesi, Marianne Strohmeyer, Alessandro Bartoloni
Neglected tropical diseases (NTDs) are a diverse group of acute and chronic conditions with distinct characteristics that thrive mainly among the poorest populations, almost exclusively in tropical countries. To evaluate the relevance and impact of NTDs in a temperate area, the number and features of patients diagnosed with NTDs at the Infectious and Tropical Diseases Unit (ITDU), Azienda Ospedaliero-Universitaria Careggi, Florence, Italy between 2000 and 2015 were retrospectively reviewed. Overall 289 NTD cases were diagnosed in 283 subjects accounting for 2...
January 4, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28052070/identifying-patient-perceived-barriers-to-trichiasis-surgery-in-kongwa-district-tanzania
#7
Ryan J Bickley, Harran Mkocha, Beatriz Munoz, Sheila West
BACKGROUND: Trachomatous trichiasis (TT), inturned eyelashes from repeated infection with Chlamydia trachomatis, is the leading infectious cause of blindness in the world. Though surgery will correct entropion caused by trachoma, uptake of TT surgery remains low. In this case-control study, we identify barriers that prevent TT patients from receiving sight-saving surgery. METHODOLOGY/PRINCIPAL FINDINGS: Participants were selected from a database of TT cases who did (acceptors) and did not (non-acceptors) have surgery as of August 2015...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28030602/structural-and-biochemical-characterization-of-chlamydia-trachomatis-dsba-reveals-a-cysteine-rich-and-weakly-oxidising-oxidoreductase
#8
Signe Christensen, Morten K Grøftehauge, Karl Byriel, Wilhelmina M Huston, Emily Furlong, Begoña Heras, Jennifer L Martin, Róisín M McMahon
The Gram negative bacteria Chlamydia trachomatis is an obligate intracellular human pathogen that can cause pelvic inflammatory disease, infertility and blinding trachoma. C. trachomatis encodes a homolog of the dithiol oxidoreductase DsbA. Bacterial DsbA proteins introduce disulfide bonds to folding proteins providing structural bracing for secreted virulence factors, consequently these proteins are potential targets for antimicrobial drugs. Despite sharing functional and structural characteristics, the DsbA enzymes studied to date vary widely in their redox character...
2016: PloS One
https://www.readbyqxmd.com/read/28030282/the-global-trachoma-mapping-project-a-catalyst-for-progress-against-neglected-tropical-diseases
#9
Dirk Engels
No abstract text is available yet for this article.
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27993657/genome-analysis-of-chlamydia-trachomatis-for-functional-characterization-of-hypothetical-proteins-to-discover-novel-drug-targets
#10
Ahmad Abu Turab Naqvi, Safikur Rahman, Rubi, Firdaus Zeya, Kundan Kumar, Hani Choudhary, Mohammad Sarwar Jamal, Jihoe Kim, Md Imtaiyaz Hassan
C. trachomatis is a Gram-negative bacterium that causes trachoma and sexually transmitted disease (STD) Chlamydia in humans. Chlamydial genital infections are the most frequent among all communicable diseases. The D/UW-3/Cx strain of C. trachomatis contains 935 genes and three pseudogenes. Out of these genes, 887 genes code for proteins while six for rRNA, 37 tRNA, and three genes translate into other RNAs. The proteome of C. trachomatis made of 887 proteins contains 269 Hypothetical proteins (HPs) that are subjected to functional characterization...
December 16, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27956455/a-cluster-randomized-trial-to-assess-the-efficacy-of-targeting-trachoma-treatment-to-children
#11
Abdou Amza, Boubacar Kadri, Beido Nassirou, Sun Y Cotter, Nicole E Stoller, Zhaoxia Zhou, Robin L Bailey, David C Mabey, Travis C Porco, Jeremy D Keenan, Bruce D Gaynor, Sheila K West, Thomas M Lietman
BACKGROUND: The World Health Organizationʼns recommendeds annual treatment of the entire trachoma-endemic communities, although children typically have a higher load, longer duration, and greater likelihood of infection. METHODS: Forty-eight communities in Matameye, Niger were randomized to annual oral azithromycin treatment of the entire community or biannual treatment of children aged 0-12 years only. Both children and adults were monitored for ocular chlamydial infection by PCR...
December 12, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27939803/history-of-trachoma
#12
L Salazar-Quiñones, M Nieves-Moreno, A Asorey-García, D Díaz-Valle, E Santos-Bueso, J García Sanchez
No abstract text is available yet for this article.
December 8, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27937043/mapping-trachoma-in-the-solomon-islands-results-of-three-baseline-population-based-prevalence-surveys-conducted-with-the-global-trachoma-mapping-project
#13
Oliver Sokana, Colin Macleod, Kelvin Jack, Robert Butcher, Michael Marks, Rebecca Willis, Brian K Chu, Claude Posala, Anthony W Solomon
PURPOSE: We sought to complete the baseline trachoma map of the Solomon Islands by establishing prevalences of active trachoma and trichiasis in the provinces of Choiseul, Western, Rennell-Bellona, and Temotu. METHODS: Using the standardized methodology developed for the Global Trachoma Mapping Project, we conducted cross-sectional community-based surveys from September to November 2013. Choiseul and Western provinces were each mapped as separate evaluation units (EUs); Rennell-Bellona and Temotu were combined to form a third EU...
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27918573/benchmarking-the-cost-per-person-of-mass-treatment-for-selected-neglected-tropical-diseases-an-approach-based-on-literature-review-and-meta-regression-with-web-based-software-application
#14
Christopher Fitzpatrick, Fiona M Fleming, Matthew Madin-Warburton, Timm Schneider, Filip Meheus, Kingsley Asiedu, Anthony W Solomon, Antonio Montresor, Gautam Biswas
BACKGROUND: Advocacy around mass treatment for the elimination of selected Neglected Tropical Diseases (NTDs) has typically put the cost per person treated at less than US$ 0.50. Whilst useful for advocacy, the focus on a single number misrepresents the complexity of delivering "free" donated medicines to about a billion people across the world. We perform a literature review and meta-regression of the cost per person per round of mass treatment against NTDs. We develop a web-based software application (https://healthy...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27918248/prevalence-of-trachoma-in-benishangul-gumuz-region-ethiopia-results-of-seven-population-based-surveys-from-the-global-trachoma-mapping-project
#15
Yilikal Adamu, Colin Macleod, Liknaw Adamu, Wirtu Fikru, Beyene Kidu, Aida Abashawl, Michael Dejene, Brian K Chu, Rebecca M Flueckiger, Rebecca Willis, Alexandre L Pavluck, Anthony W Solomon
PURPOSE: Trachoma is a major cause of blindness in Ethiopia, and targeted for elimination as a public health problem by the year 2020. Prevalence data are needed to plan interventions. We set out to estimate the prevalence of trachoma in each evaluation unit of grouped districts ("woredas") in Benishangul Gumuz region, Ethiopia. METHODS: We conducted seven cross-sectional community-based surveys, covering 20 woredas, between December 2013 and January 2014, as part of the Global Trachoma Mapping Project (GTMP)...
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27918232/the-prevalence-of-trachoma-in-tigray-region-northern-ethiopia-results-of-11-population-based-prevalence-surveys-completed-as-part-of-the-global-trachoma-mapping-project
#16
Sadik Taju Sherief, Colin Macleod, Goitum Gigar, Hagos Godefay, Atakelit Abraha, Michael Dejene, Amir B Kello, Aberash Belete, Yitbarek Assefa, Rebecca Willis, Brian K Chu, Anthony W Solomon
PURPOSE: We aimed to estimate the prevalence of trachoma in each district ("woreda") of Tigray Region, Ethiopia. METHODS: We conducted 11 cross-sectional community-based surveys in evaluation units covering 34 rural woredas from January to March 2013 using the standardized methodology developed for the Global Trachoma Mapping Project. RESULTS: Teams visited 8034 households in 275 villages. A total of 28,581 consenting individuals were examined, 16,163 (56...
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27918229/prevalence-of-and-risk-factors-for-trachoma-in-southern-nations-nationalities-and-peoples-region-ethiopia-results-of-40-population-based-prevalence-surveys-carried-out-with-the-global-trachoma-mapping-project
#17
Tesfaye Haileselassie Adera, Colin Macleod, Misganu Endriyas, Michael Dejene, Rebecca Willis, Brian K Chu, Yohannes Letamo, Tebeje Misganaw, Tamiru Mesele, Emebet Mekonnen, Alemayehu Sisay, Yeneneh Mulugeta, Wondu Alemayehu, Khumbo Kalua, Tezera Kifle Destu, Yilikal Adamu, Jennifer L Smith, Abu Beyene, Addisu Tadesse, Anthony W Solomon
PURPOSE: We sought to estimate the prevalence of trachoma at sufficiently fine resolution to allow elimination interventions to begin, where required, in the Southern Nations, Nationalities, and Peoples' Region (SNNPR) of Ethiopia. METHODS: We carried out cross-sectional population-based surveys in 14 rural zones. A 2-stage cluster randomized sampling technique was used. A total of 40 evaluation units (EUs) covering 110 districts ("woredas") were surveyed from February 2013 to May 2014 as part of the Global Trachoma Mapping Project (GTMP), using the standardized GTMP training package and methodology...
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27918227/mapping-trachoma-in-kaduna-state-nigeria-results-of-23-local-government-area-level-population-based-prevalence-surveys
#18
Nasiru Muhammad, Caleb Mpyet, Mohammed Dantani Adamu, Adamani William, Murtala Muhammad Umar, Musa Goyol, Habila Muazu, Uwaezuoke Onyebuchi, Sunday Isiyaku, Rebecca M Flueckiger, Brian K Chu, Rebecca Willis, Alexandre L Pavluck, Abdullahi Alhassan, Nicholas Olobio, Bruce A Gordon, Anthony W Solomon
INTRODUCTION: To prepare for global elimination of trachoma by 2020, the World Health Organization (WHO) recommends mapping of trachoma at district-level to enable planning of elimination activities in affected populations. The aim of our study was to provide data on trachoma for each local government area (LGA) of Kaduna State, Nigeria, as such data were previously unavailable. METHOD: As part of the Global Trachoma Mapping Project (GTMP), a population-based cross-sectional trachoma survey was conducted in each of the 23 LGAs of Kaduna State, between May and June 2013...
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27918223/prevalence-of-trachoma-in-niger-state-north-central-nigeria-results-of-25-population-based-prevalence-surveys-carried-out-with-the-global-trachoma-mapping-project
#19
Mohammed Dantani Adamu, Caleb Mpyet, Nasiru Muhammad, Murtala Muhammad Umar, Habila Muazu, Francisca Olamiju, Sunday Isiyaku, Uwazoeke Onyebuchi, Usman Abubakar Bosso, Adamani William, Benjamin C Nwobi, Rebecca Willis, Rebecca Mann Flueckiger, Alexandre Pavluck, Brian K Chu, Nicholas Olobio, Anthony W Solomon
PURPOSE: To determine the prevalence of trachoma in each of the 25 local government areas (LGAs) of Niger State, Nigeria. METHODS: A population-based cross-sectional survey was conducted in each Niger State LGA between March and April 2014, as part of the Global Trachoma Mapping Project (GTMP). GTMP protocols were used in planning and conduct of the surveys. Using probability proportional to size, 25 clusters were selected; in each of these clusters, 25 households were enrolled for the survey...
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27918222/prevalence-of-trachoma-in-gambella-region-ethiopia-results-of-three-population-based-prevalence-surveys-conducted-with-the-global-trachoma-mapping-project
#20
Aida Abashawl, Colin Macleod, John Riang, Ferede Mossisa, Michael Dejene, Rebecca Willis, Rebecca M Flueckiger, Alexandre L Pavluck, Addisu Tadesse, Tesfaye Haileselassie Adera, Anthony W Solomon
PURPOSE: In Ethiopia, trachoma is a major public health problem, accounting for 11.5% of all cases of blindness. In Gambella, one of the country's most remote regions, the 2005-2006 National Survey of Blindness, Low Vision and Trachoma estimated a region-level prevalence of active trachoma of 19.1% in those aged 1-9 years. Detailed district or sub-regional level estimates are required to implement interventions. METHODS: Population-based prevalence surveys were carried out following a 2-stage cluster random sampling methodology and Global Trachoma Mapping Project protocols...
2016: Ophthalmic Epidemiology
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