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https://www.readbyqxmd.com/read/29762330/management-of-severe-cicatricial-entropion-with-labial-mucous-membrane-graft-in-cicatricial-ocular-surface-disorders
#1
Tammy H Osaki, Ana Estela Sant'Anna, Midori H Osaki, Don O Kikkawa, Cristina Yabumoto, Patrick Yang, Bobby S Korn
The management of cicatricial entropion represents a therapeutic challenge especially when the underlying causes are progressive cicatricial diseases that affect the ocular surface. The authors aimed to report long-term efficacy of labial mucous membrane graft to manage severe cicatricial entropion of the upper eyelid. This study is a retrospective chart review of patients who underwent tarsotomy associated with labial mucous membrane graft to treat severe cicatricial entropion of the upper eyelid. Surgeries were performed over a 16-year period...
May 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29743637/detection-of-chlamydiaceae-and-chlamydia-like-organisms-on-the-ocular-surface-of-children-and-adults-from-a-trachoma-endemic-region
#2
Ehsan Ghasemian, Aleksandra Inic-Kanada, Astrid Collingro, Florian Tagini, Elisabeth Stein, Hadeel Alchalabi, Nadine Schuerer, Darja Keše, Balgesa Elkheir Babiker, Nicole Borel, Gilbert Greub, Talin Barisani-Asenbauer
Trachoma, the leading infectious cause of blindness, is caused by Chlamydia trachomatis (Ct), a bacterium of the phylum Chlamydiae. Recent investigations revealed the existence of additional families within the phylum Chlamydiae, also termed Chlamydia-like organisms (CLOs). In this study, the frequency of Ct and CLOs was examined in the eyes of healthy Sudanese (control) participants and those with trachoma (case). We tested 96 children (54 cases and 42 controls) and 93 adults (51 cases and 42 controls) using broad-range Chlamydiae and Ct-specific (omcB) real-time PCR...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29741592/ocular-chlamydia-trachomatis-infection-under-the-safe-strategy-in-amhara-ethiopia-2011-2015
#3
Scott D Nash, Aisha E P Stewart, Mulat Zerihun, Eshetu Sata, Demelash Gessese, Berhanu Melaku, Tekola Endeshaw, Melsew Chanyalew, Ambahun Chernet, Belay Bayissasse, Jeanne Moncada, Thomas M Lietman, Paul M Emerson, Jonathan D King, Zerihun Tadesse, E Kelly Callahan
Background: WHO recommendations for starting and stopping mass antibiotic distributions are based on a clinical sign of trachoma, which is indirectly related to actual infection with the causative agent, Chlamydia trachomatis. Methods: This study aimed to understand the effect of SAFE (surgery, antibiotics, facial cleanliness, and environmental improvement) interventions on ocular chlamydia in Amhara, Ethiopia by describing the infection prevalence in a population-based sample of children ages 1-5 years...
May 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29692244/inhibition-of-chlamydia-trachomatis-growth-during-the-last-decade-a-mini-review
#4
Nawal Serradji, V U Thi Huyen, Hyunjoon Kim, Jayanth Panyam, Philippe Verbeke
Chlamydia trachomatis is responsible for the most frequent sexually transmitted bacterial infection in the world and for trachoma, the world's leading infectious cause of blindness. Genital chlamydial infection is very common among sexually active young people, and when untreated, leads to serious complications. No vaccine is available. Although Chlamydia resistance to antibiotics is rarely observed in vivo, studies showed that 10-20% of patients remain infected at the end of antibiotherapy, without being reinfected...
April 23, 2018: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29665861/trachoma-in-yunnan-province-of-southwestern-china-findings-from-trachoma-rapid-assessment
#5
Min Wu, Zhu Lin Hu, Dan He, Wen Rong Xu, Yan Li
BACKGROUND: To understand the situation of active trachoma among children aged 6 to 8 years old and scarring trachoma among those aged 15 and over in Yunnan Province, South-western China. METHODS: A rapid assessment of trachoma was conducted to determine the presence or absence of trachoma in Yunnan. Through risk assessment, 9 sites in 8 suspected trachoma epidemic counties were selected. Trachoma Rapid Assessment was conducted in these areas afterwards. Within each sites, 50 students from grade one in local primary school and adults aged 15 and above with suspected scarring trachoma were examined by survey teams...
April 17, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29617922/chlamydial-ompa-diversity-in-trachoma-hyperendemic-communities-treated-with-azithromycin
#6
Stephanie A Chin, Daniel P Morberg, Wondu Alemayehu, Muluken Melese, Takele Lakew, Michael C Chen, Zhaoxia Zhou, Thuy Doan, Vicky Cevallos, Thomas M Lietman, Jeremy D Keenan
Prior studies have theorized that low chlamydial genetic diversity following mass azithromycin treatments for trachoma may create a population bottleneck that prevents the return of infection, but little empiric evidence exists to support this hypothesis. In this study, a single mass azithromycin distribution was administered to 21 communities in the Gurage Zone of Ethiopia in 2003. All children aged 1-5 years had conjunctival swabs performed before treatment, and at 2 and 6 months following treatment. All swabs positive for Chlamydia trachomatis at 2 months underwent ompA typing, as did the same number of swabs per community from the pre-treatment and 6-month visits...
April 3, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29588922/clinical-signs-of-trachoma-are-prevalent-among-solomon-islanders-who-have-no-persistent-markers-of-prior-infection-with-chlamydia-trachomatis
#7
Robert Butcher, Oliver Sokana, Kelvin Jack, Leslie Sui, Charles Russell, Anna Last, Diana L Martin, Matthew J Burton, Anthony W Solomon, David C W Mabey, Chrissy H Roberts
Background: The low population-prevalence of trachomatous trichiasis and high prevalence of trachomatous inflammation-follicular (TF) provide contradictory estimates of the magnitude of the public health threat from trachoma in the Solomon Islands. Improved characterisation of the biology of trachoma in the region may support policy makers as they decide what interventions are required. Here, age-specific profiles of anti-Pgp3 antibodies and conjunctival scarring were examined to determine whether there is evidence of ongoing transmission and pathology from ocular Chlamydia trachomatis (Ct) infection...
2018: Wellcome Open Research
https://www.readbyqxmd.com/read/29563718/-chlamydia-trachomatis-antigen-positivity-in-patients-with-different-ocular-manifestations-over-8-years
#8
Nishat Hussain Ahmed, Anjana Sharma, Gita Satpathy, Jeewan Singh Titiyal, Radhika Tandon, Tushar Agarwal, M Vanathi, Namrata Sharma
Laboratory confirmation of chlamydial antigen in clinically suspected cases of chlamydial eye infections is important, as similar clinical picture can be presented by different infective or noninfective causes. We retrospectively analyzed the presence of Chlamydia trachomatis antigen in 690 clinically suspected patients over the last 8 years (2009-2016). The chlamydial antigen was detected using direct immunofluorescence assay. Overall, Chlamydia -specific antigen positivity was 45.5%. The highest positivity was seen in 2014 (68...
January 2018: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29561511/childhood-mortality-after-mass-distribution-of-azithromycin-a-secondary-analysis-of-the-pret-cluster-randomized-trial-in-niger
#9
Kieran S O'Brien, Sun Y Cotter, Abdou Amza, Boubacar Kadri, Beido Nassirou, Nicole E Stoller, Zhaoxia Zhou, Sheila K West, Robin L Bailey, Jeremy D Keenan, Travis C Porco, Thomas M Lietman
BACKGROUND: Mass distributions of azithromycin for trachoma have been associated with secondary benefits, including reductions in child mortality. METHODS: In the PRET cluster-randomized trial for trachoma in Niger, 24 communities were randomized to annual treatment of everyone and 24 communities were randomized to biannual treatment of children under 12 for 3 years (clinicaltrials.gov, NCT00792922). Treatment was a single dose of directly observed oral azithromycin (20mg/kg up to 1gm in adults)...
March 14, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29538594/anterior-tarsal-flap-rotation-combined-with-anterior-lamellar-reposition-in-the-repair-of-cicatricial-upper-eyelid-entropion
#10
Selam Yekta Sendul, Burcu Dirim, Cemile Ucgul Atılgan, Mehmet Demir, Ali Olgun, Semra Tiryaki Demir, Saniye Uke Uzun, Gurcan Dogukan Arsalan, Dilek Guven
PURPOSE: This study aimed to share the results of patients who underwent anterior tarsal flap rotation combined with anterior lamellar reposition because of cicatricial upper eyelid entropion, and to determine the effectiveness and reliability of this surgical technique. METHODS: Fifteen eyes of 11 patients (2 right eyes; 5 left eyes; and 4 bilateral eyes) on whom we performed anterior tarsal flap rotation surgery combined with anterior lamellar reposition because of cicatricial entropion were included in this study...
January 2018: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29523810/latent-class-modeling-to-compare-testing-platforms-for-detection-of-antibodies-against-the-chlamydia-trachomatis-antigen-pgp3
#11
Ryan E Wiegand, Gretchen Cooley, Brook Goodhew, Natalie Banniettis, Stephan Kohlhoff, Sarah Gwyn, Diana L Martin
Latent class modeling can be used to combine the results of multiple tests to compare the sensitivity and specificity of those tests in the absence of a gold standard. Seroepidemiology for chlamydia infection may be useful for determining the cumulative risk of infection within a population. Initial studies using the Chlamydia trachomatis immunodominant antigen Pgp3 have shown utility for seroepidemiology of sexually transmitted chlamydia and the eye disease trachoma. We present our latent class modeling results for comparison of antibody data obtained from three different Pgp3-based platforms - multiplex bead array, ELISA, and lateral flow assay...
March 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29513663/correction-prevalence-of-active-and-latent-yaws-in-the-solomon-islands-18-months-after-azithromycin-mass-drug-administration-for-trachoma
#12
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pntd.0004927.].
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29504955/meibography-of-eyes-with-sequelae-of-trachoma
#13
Abdulrahman AlDarrab, Yasser H Al-Faky, Ahmed Mousa, Adel H Alsuhaibani
PURPOSE: To study the effect of trachoma on meibomian glands using infrared meibography and to correlate the results with tear film parameters. METHODS: This is a prospective cohort study in which 86 eyes of healthy volunteers and 90 eyes with trachoma were included. Clinical assessment was performed including the following: slit-lamp examination looking for signs of sequelae of trachoma, tear breakup time (TBUT), superficial punctate keratopathy (SPK), Schirmer II test (with anesthesia), and meibum score...
April 2018: Cornea
https://www.readbyqxmd.com/read/29504385/diagnosis-of-a-neonatal-ophthalmic-discharge-ophthalmia-neonatorum-in-the-%C3%A2-molecular-age%C3%A2-investigation-for-a-correct-therapy
#14
P E Gallenga, M Del Boccio, C E Gallenga, G Neri, A Pennelli, E Toniato, L Lobefalo, M Maritati, P Perri, C Contini, G Del Boccio
An early double case of acute Ophthalmia neonatorum in 3-day-old twins is reported. Culture of eye swabs showed a wide bacterial polymorphism, in which common bacteria, such as Klebsiella pneumoniae, Streptococcus pneumoniae, Corynebacterium ulcerans and other Enterobacteriaceae, coexisted with atypical Mycoplasmataceae and Chlamydiaceae from resident cervical-vaginal maternal microbiota. The neonates were in an apparently healthy state, but showed red eyes with abundant greenish-yellow secretion, mild chemosis and lid edema...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29501689/evaluation-of-the-reproducibility-of-a-serological-test-for-antibodies-to-chlamydia-trachomatis-pgp3-a-potential-surveillance-tool-for-trachoma-programs
#15
Hemjot Kaur, Laura Dize, Beatriz Munoz, Charlotte Gaydos, Sheila K West
PURPOSE: Serological testing for antibodies to Chlamydia trachomatis pgp3 is being evaluated as a tool to use for trachoma surveillance. There are limited data on the reproducibility of the test results using a multiplex platform. METHODS: We tested the reproducibility of a serologic test for C. trachomatis pgp3 in 6 dried blood spots collected from a random sample of 45 children from a trachoma endemic area. The spots were tested on a multiplex bead array platform, using one bead set twice, using another bead set at the same time as the first, and using the same bead set twice on different days separated by several months...
April 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29501483/comparison-of-long-term-results-between-osteo-odonto-keratoprosthesis-and-tibial-bone-keratoprosthesis
#16
Victor Charoenrook, Ralph Michael, Maria Fideliz de la Paz, José Temprano, Rafael I Barraquer
PURPOSE: To compare the anatomical and the functional results between osteo-odonto-keratoprosthesis (OOKP) and keratoprosthesis using tibial bone autograft (Tibial bone KPro). METHODS: We reviewed the charts of 258 patients; 145 had OOKP whereas 113 had Tibial bone KPro implanted. Functional success was defined as best corrected visual acuity ≥0.05 on decimal scale and anatomical success as retention of the keratoprosthesis lamina. Kaplan-Meier survival curves were calculated for anatomical and functional survival as well as to estimate the probability of post-op complications...
April 2018: Ocular Surface
https://www.readbyqxmd.com/read/29482619/population-based-analysis-of-ocular-chlamydia-trachomatis-in-trachoma-endemic-west-african-communities-identifies-genomic-markers-of-disease-severity
#17
A R Last, H Pickering, C H Roberts, F Coll, J Phelan, S E Burr, E Cassama, M Nabicassa, H M B Seth-Smith, J Hadfield, L T Cutcliffe, I N Clarke, D C W Mabey, R L Bailey, T G Clark, N R Thomson, M J Holland
BACKGROUND: Chlamydia trachomatis (Ct) is the most common infectious cause of blindness and bacterial sexually transmitted infection worldwide. Ct strain-specific differences in clinical trachoma suggest that genetic polymorphisms in Ct may contribute to the observed variability in severity of clinical disease. METHODS: Using Ct whole genome sequences obtained directly from conjunctival swabs, we studied Ct genomic diversity and associations between Ct genetic polymorphisms with ocular localization and disease severity in a treatment-naïve trachoma-endemic population in Guinea-Bissau, West Africa...
February 26, 2018: Genome Medicine
https://www.readbyqxmd.com/read/29481558/coverage-social-mobilization-and-challenges-of-mass-zithromax-administration-campaign-in-south-and-south-east-zones-of-tigray-northern-ethiopia-a-cross-sectional-study
#18
Afework Mulugeta, Gebremedhin Berhe Gebregergs, Selamawit Asfaw, Dejen Yemane, Mengistu Mitiku, Beyene Meresa, Goitom Gigar, Amanuel Kidane
BACKGROUND: The antibiotic treatment of people with trachoma helps to prevent transmission the disease in a community. Currently, Zithromax is the drug recommended for mass drug administration (MDA). MDA should be carried out annually for three to five years in trachoma endemic areas. Coverage survey is essential to track progress towards program goals and to identify communities with poor coverage in order to permit timely and appropriate actions. We assessed mass Zithromax administration coverage, social mobilization and campaign challenges in south and southeast zones of Tigray, Ethiopia...
February 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29476106/longitudinal-change-in-the-serology-of-antibodies-to-chlamydia-trachomatis-pgp3-in-children-residing-in-a-trachoma-area
#19
Sheila K West, Beatriz Munoz, Hemjot Kaur, Laura Dize, Harran Mkocha, Charlotte A Gaydos, Thomas C Quinn
A serologic test for antibodies to chlamydial antigen pgp3 may be a useful tool for trachoma surveillance. However, little is known about the stability of antibody status over time, or factors associated with seroreversion/conversion. A cohort of 2,111 children ages 1-9 years in Tanzania were followed for one year in the absence of mass azithromycin. At baseline and follow-up, they were evaluated for trachoma, chlamydial infection, and antibodies to chlamydial antigen pgp3. At baseline, 31% of children were seropositive for pgp3 antibodies and 6...
February 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29467021/conjunctival-transcriptome-profiling-of-solomon-islanders-with-active-trachoma-in-the-absence-of-chlamydia-trachomatis-infection
#20
Hristina Vasileva, Robert Butcher, Harry Pickering, Oliver Sokana, Kelvin Jack, Anthony W Solomon, Martin J Holland, Chrissy H Roberts
BACKGROUND: Clinical signs of active (inflammatory) trachoma are found in many children in the Solomon Islands, but the majority of these individuals have no serological evidence of previous infection with Chlamydia trachomatis. In Temotu and Rennell and Bellona provinces, ocular infections with C. trachomatis were seldom detected among children with active trachoma; a similar lack of association was seen between active trachoma and other common bacterial and viral causes of follicular conjunctivitis...
February 21, 2018: Parasites & Vectors
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