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https://www.readbyqxmd.com/read/28641033/evaluation-of-planned-bicanalicular-nasolacrimal-tube-retention-in-treating-punctal-stenosis-or-occlusion-secondary-to-trachoma
#1
Rania A Ahmed, Ahmed M Kamal, Mohamed A Zayed
This article evaluates retaining bicanalicular silicone nasolacrimal tube in patients susceptible to restenosis after punctoplasty. Sixty-nine eyes (38 patients) suffering from epiphora due to stenosis or occlusion of both punctae were included in this prospective study. All had 3 snip punctoplasty and bicanalicular silicone nasolacrimal duct insertion. Cases associated with proximal canalicular stenosis or obstructions were excluded. Tolerance to tube presence until the time of loss or removal was evaluated using a score (0 to 2)...
June 22, 2017: Orbit
https://www.readbyqxmd.com/read/28621840/association-of-disease-specific-causes-of-visual-impairment-and-10-year-mortality-among-indigenous-australians-the-central-australian-ocular-health-study
#2
José Estevez, Georgia Kaidonis, Tim Henderson, Jamie E Craig, John Landers
IMPORTANCE: Visual impairment significantly impairs the length and quality of life but little is known of its impact in Indigenous Australians. BACKGROUND: To investigate the association of disease-specific causes of visual impairment with all-cause mortality. DESIGN: Retrospective cohort analysis. PARTICIPANTS: 1,347 Indigenous Australians aged over 40 years. METHODS: Participants visiting remote medical clinics underwent clinical examinations including visual acuity, subjective refraction and slit-lamp examination of the anterior and posterior segments...
June 16, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28614375/burden-of-trachoma-in-five-counties-of-eastern-equatoria-state-south-sudan-results-from-population-based-surveys
#3
Angelia M Sanders, Aisha E P Stewart, Samuel Makoy, Joy J Chebet, Peter Magok, Aja Kuol, Carla Blauvelt, Richard Lako, John Rumunu, E Kelly Callahan, Scott D Nash
BACKGROUND: In order to decrease the prevalence of trachoma within the country, the Republic of South Sudan has implemented components of the SAFE strategy in various counties since 2001. Five counties in Eastern Equatoria state were surveyed in order to monitor progress of programmatic interventions and determine if additional rounds of Mass Drug Administration with azithromycin were needed. METHODOLOGY/ PRINCIPAL FINDINGS: Five counties (Budi, Lafon, Kapoeta East, Kapoeta South and Kapoeta North) were surveyed from April to October 2015...
June 14, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28607177/burden-of-vision-loss-associated-with-eye-disease-in-china-1990-2020-findings-from-the-global-burden-of-disease-study-2015
#4
Bingsong Wang, Nathan Congdon, Rupert Bourne, Yichong Li, Kai Cao, Aiping Zhao, Mayinuer Yusufu, Wenlan Dong, Maigeng Zhou, Ningli Wang
AIMS: To assess the burden of vision loss due to eye disease in China between 1990 and 2015, and to predict the burden in 2020. METHODS: Data from the GBD 2015 (Global Burden of Diseases, Injuries, and Risk Factors Study 2015) were used. The main outcome measures were prevalence and years lived with disability (YLDs) for vision loss due to cataract, glaucoma, macular degeneration, other vision loss, refraction and accommodation disorders and trachoma. RESULTS: Prevalence for eye diseases increased steadily from 1990 to 2015, and will increase until 2020...
June 12, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28602619/the-impact-of-sanitation-on-infectious-disease-and-nutritional-status-a-systematic-review-and-meta-analysis
#5
REVIEW
Matthew C Freeman, Joshua V Garn, Gloria D Sclar, Sophie Boisson, Kate Medlicott, Kelly T Alexander, Gauthami Penakalapati, Darcy Anderson, Amrita G Mahtani, Jack E T Grimes, Eva A Rehfuess, Thomas F Clasen
BACKGROUND: Sanitation aims to sequester human feces and prevent exposure to fecal pathogens. More than 2.4 billion people worldwide lack access to improved sanitation facilities and almost one billion practice open defecation. We undertook systematic reviews and meta-analyses to compile the most recent evidence on the impact of sanitation on diarrhea, soil-transmitted helminth (STH) infections, trachoma, schistosomiasis, and nutritional status assessed using anthropometry. METHODS AND FINDINGS: We updated previously published reviews by following their search strategy and eligibility criteria...
May 31, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28598533/prevalence-of-trachomatous-trichiasis-in-australia-the-national-eye-health-survey
#6
Mohamed Dirani, Stuart Keel, Joshua Foreman, Peter van Wijngaarden, Hugh R Taylor
IMPORTANCE: Australia is the only developed country to still have pockets of endemic trachoma. The research provides up-to-date, population-based prevalence data of later complications of trachoma amongst a national sample of Indigenous adults. BACKGROUND: To report the prevalence of trachomatous trichiasis (TT) in Indigenous Australians aged 40 years and over. DESIGN: Population-based cross-sectional study PARTICIPANTS: A total of 1738 (41% male) Indigenous Australians aged 40 years or older, living among 30 randomly selected Australian sites, stratified by remoteness...
June 9, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28593198/biphasic-metabolism-and-host-interaction-of-a-chlamydial-symbiont
#7
Lena König, Alexander Siegl, Thomas Penz, Susanne Haider, Cecilia Wentrup, Julia Polzin, Evelyne Mann, Stephan Schmitz-Esser, Daryl Domman, Matthias Horn
Chlamydiae are obligate intracellular bacteria comprising well-known human pathogens and ubiquitous symbionts of protists, which are characterized by a unique developmental cycle. Here we comprehensively analyzed gene expression dynamics of Protochlamydia amoebophila during infection of its Acanthamoeba host by RNA sequencing. This revealed a highly dynamic transcriptional landscape, where major transcriptional shifts are conserved among chlamydial symbionts and pathogens. Our data served to propose a time-resolved model for type III protein secretion during the developmental cycle, and we provide evidence for a biphasic metabolism of P...
May 2017: MSystems
https://www.readbyqxmd.com/read/28584542/morocco-succeeds-to-eliminate-trachoma-as-a-public-health-problem-world-health-organization
#8
Saurabh RamBihariLal Shrivastava, Prateek Saurabh Shrivastava, Jegadeesh Ramasamy
No abstract text is available yet for this article.
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28562672/rapid-detection-and-strain-typing-of-chlamydia-trachomatis-using-a-highly-multiplexed-microfluidic-pcr-assay
#9
Rosemary S Turingan, Ludmila Kaplun, Greice Krautz-Peterson, Sarah Norsworthy, Anna Zolotova, Sandeep J Joseph, Timothy D Read, Deborah Dean, Eugene Tan, Richard F Selden
Nucleic acid amplification tests (NAATs) are recommended by the CDC for detection of Chlamydia trachomatis (Ct) urogenital infections. Current commercial NAATs require technical expertise and sophisticated laboratory infrastructure, are time-consuming and expensive, and do not differentiate the lymphogranuloma venereum (LGV) strains that require a longer duration of treatment than non-LGV strains. The multiplexed microfluidic PCR-based assay presented in this work simultaneously interrogates 13 loci to detect Ct and identify LGV and non-LGV strain-types...
2017: PloS One
https://www.readbyqxmd.com/read/28546072/dendrimer-conjugated-peptide-vaccine-enhances-clearance-of-chlamydia-trachomatis-genital-infection
#10
Ingrid S Ganda, Qian Zhong, Mirabela Hali, Ricardo L C Albuquerque, Francine F Padilha, Sandro R P da Rocha, Judith A Whittum-Hudson
Peptide-based vaccines have emerged in recent years as promising candidates in the prevention of infectious diseases. However, there are many challenges to maintaining in vivo peptide stability and enhancement of peptide immunogenicity to generate protective immunity which enhances clearance of infections. Here, a dendrimer-based carrier system is proposed for peptide-based vaccine delivery, and shows its anti-microbial feasibility in a mouse model of Chlamydia trachomatis. Chlamydiae are the most prevalent sexually transmitted bacteria worldwide, and also the causal agent of trachoma, the leading cause of preventable infectious blindness...
May 22, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28542225/the-impact-of-health-promotion-on-trachoma-knowledge-attitudes-and-practice-kap-of-staff-in-three-work-settings-in-remote-indigenous-communities-in-the-northern-territory
#11
Fiona D Lange, Kelly Jones, Rebecca Ritte, Haley E Brown, Hugh R Taylor
BACKGROUND: Globally, trachoma is the leading cause of infectious blindness and Australia is the only developed country with endemic trachoma. It is found in remote Indigenous communities burdened with poverty, overcrowding and poor hygiene. Lack of culturally appropriate health promotion, a small trachoma workforce and lack of awareness and support for trachoma elimination in general, were early barriers. METHODS: A cross-sectional pre-post study using a convenience sample, was conducted in clinics, schools and community work-settings from 63 of the 82 remote Aboriginal communities identified as being at risk of trachoma in the Northern Territory (NT)...
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28535271/measuring-trachomatous-inflammation-intense-ti-when-prevalence-is-low-provides-data-on-infection-with-chlamydia-trachomatis
#12
Andrea I Zambrano, Beatriz E Muñoz, Harran Mkocha, Laura Dize, Charlotte A Gaydos, Thomas Quinn, Sheila K West
Purpose: Clinical trachoma is the current measure of effectiveness of antibiotic and environmental improvements in trachoma endemic communities. Impact assessments measure only trachomatous inflammation-follicular (TF). Trachomatous inflammation-intense (TI) is not used for decisions on stopping mass drug administration (MDA) or achieving intervention goals. We tested the supposition that TI was not associated with Chlamydia trachomatis when disease prevalence is low. Methods: In 35 communities undergoing MDA as part of a larger project, 110 children ages 1 to 9 years were randomly selected in each community for surveys at baseline, 6, and 12 months...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28532208/the-burden-of-and-risk-factors-for-trachoma-in-selected-districts-of-zimbabwe-results-of-16-population-based-prevalence-surveys
#13
Isaac Phiri, Portia Manangazira, Colin K Macleod, Takafira Mduluza, Tinashe Dhobbie, Shorai Grace Chaora, Chriswell Chigwena, Joshua Katiyo, Rebecca Willis, Ana Bakhtiari, Peter Bare, Paul Courtright, Boniface Macheka, Nicholas Midzi, Anthony W Solomon
BACKGROUND: Trachoma, a leading cause of blindness, is targeted for global elimination as a public health problem by 2020. In order to contribute to this goal, countries should demonstrate reduction of disease prevalence below specified thresholds, after implementation of the SAFE strategy in areas with defined endemicity. Zimbabwe had not yet generated data on trachoma endemicity and no specific interventions against trachoma have yet been implemented. METHODS: Two trachoma mapping phases were successively implemented in Zimbabwe, with eight districts included in each phase, in September 2014 and October 2015...
May 22, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28487054/reduced-cost-chlamydia-trachomatis-specific-multiplex-real-time-pcr-diagnostic-assay-evaluated-for-ocular-swabs-and-use-by-trachoma-research-programmes
#14
Robert Butcher, Jo Houghton, Tamsyn Derrick, Athumani Ramadhani, Beatriz Herrera, Anna R Last, Patrick A Massae, Matthew J Burton, Martin J Holland, Chrissy H Roberts
INTRODUCTION: Trachoma, caused by the intracellular bacterium Chlamydia trachomatis (Ct), is the leading infectious cause of preventable blindness. Many commercial platforms are available that provide highly sensitive and specific detection of Ct DNA. However, the majority of these commercial platforms are inaccessible for population-level surveys in resource-limited settings typical to trachoma control programmes. We developed two low-cost quantitative PCR (qPCR) tests for Ct using readily available reagents on standard real-time thermocyclers...
May 6, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28479620/active-trachoma-and-community-use-of-sanitation-ethiopia
#15
William E Oswald, Aisha Ep Stewart, Michael R Kramer, Tekola Endeshaw, Mulat Zerihun, Berhanu Melak, Eshetu Sata, Demelash Gessese, Tesfaye Teferi, Zerihun Tadesse, Birhan Guadie, Jonathan D King, Paul M Emerson, Elizabeth K Callahan, Dana Flanders, Christine L Moe, Thomas F Clasen
OBJECTIVE: To investigate, in Amhara, Ethiopia, the association between prevalence of active trachoma among children aged 1-9 years and community sanitation usage. METHODS: Between 2011 and 2014, prevalence of trachoma and household pit latrine usage were measured in five population-based cross-sectional surveys. Data on observed indicators of latrine use were aggregated into a measure of community sanitation usage calculated as the proportion of households with a latrine in use...
April 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28472466/spatial-clustering-of-high-load-ocular-chlamydia-trachomatis-infection-in-trachoma-a-cross-sectional-population-based-study
#16
Anna Last, Sarah Burr, Neal Alexander, Emma Harding-Esch, Chrissy H Roberts, Meno Nabicassa, Eunice Teixeira da Silva Cassama, David Mabey, Martin Holland, Robin Bailey
Chlamydia trachomatis (Ct) is the most common cause of bacterial sexually transmitted infection and infectious cause of blindness (trachoma) worldwide. Understanding the spatial distribution of Ct infection may enable us to identify populations at risk and improve our understanding of Ct transmission. In this study, we sought to investigate the spatial distribution of Ct infection and the clinical features associated with high Ct load in trachoma-endemic communities on the Bijagós Archipelago (Guinea Bissau)...
July 31, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28441120/prevalence-of-trachoma-in-northern-benin-results-from-11-population-based-prevalence-surveys-covering-26-districts
#17
Amadou Alfa Bio, Pelagie M Boko, Yannelle A Dossou, Jean-Jacques Tougoue, Achille Kabore, Ignace Sounouvou, Jean-Eudes Biaou, Lionel Nizigama, Paul Courtright, Anthony W Solomon, Lisa Rotondo, Wilfrid Batcho, Dorothée Kinde-Gazard
AIMS: We sought to evaluate trachoma prevalence in all suspected-endemic areas of Benin. METHODS: We conducted population-based surveys covering 26 districts grouped into 11 evaluation units (EUs), using a two-stage, systematic and random, cluster sampling design powered at EU level. In each EU, 23 villages were systematically selected with population proportional to size; 30 households were selected from each village using compact segment sampling. In selected households, we examined all consenting residents aged one year or above for trichiasis, trachomatous inflammation - follicular (TF), and trachomatous inflammation - intense...
April 25, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28438414/predictors-of-trachomatous-trichiasis-surgery-outcome
#18
Esmael Habtamu, Tariku Wondie, Sintayehu Aweke, Zerihun Tadesse, Mulat Zerihun, Bizuayehu Gashaw, Guadie S Wondimagegn, Hiwot D Mengistie, Saul N Rajak, Kelly Callahan, Helen A Weiss, Matthew J Burton
PURPOSE: Unfavorable outcomes after trachomatous trichiasis (TT) surgery are undermining the global trachoma elimination effort. This analysis investigates predictors of postoperative TT (PTT), eyelid contour abnormalities (ECAs), and granuloma in the 2 most common TT surgery procedures: posterior lamellar tarsal rotation (PLTR) and bilamellar tarsal rotation (BLTR). DESIGN: Secondary data analysis from a randomized, controlled, single-masked clinical trial. PARTICIPANTS: A total of 1000 patients with TT, with lashes touching the eye or evidence of epilation, in association with tarsal conjunctival scarring...
April 21, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28426814/progress-and-projections-in-the-program-to-eliminate-trachoma
#19
Paul M Emerson, Pamela J Hooper, Virginia Sarah
No abstract text is available yet for this article.
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28396349/biochemical-and-genetic-analysis-of-the-chlamydia-groel-chaperonins
#20
Melissa Illingworth, Anna J Hooppaw, Lu Ruan, Derek J Fisher, Lingling Chen
Chaperonins are essential for cellular growth under normal and stressful conditions and consequently represent one of the most conserved and ancient protein classes. The paradigm Escherichia coli chaperonin, EcGroEL, and its cochaperonin, EcGroES, assist in the folding of proteins via an ATP-dependent mechanism. In addition to the presence of groEL and groES homologs, groEL paralogs are found in many bacteria, including pathogens, and have evolved poorly understood species-specific functions. Chlamydia spp...
June 15, 2017: Journal of Bacteriology
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