keyword
MENU ▼
Read by QxMD icon Read
search

trachoma

keyword
https://www.readbyqxmd.com/read/29164260/two-southeast-asian-countries-eliminate-trachoma
#1
M J Friedrich
No abstract text is available yet for this article.
November 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29158904/follow-up-and-report-on-active-trachoma-in-zabol-iran-prompted-by-sharifi-rad-and-fallah-s-observations-published-in-may-2016
#2
S-F Mohammadi, A Bazi-Shad, J Akbarizadeh, E Ashrafi, Z Moinfar, E Shirdel, M Nabavi, S Samiei, S Salehi-Rad, A W Solomon
No abstract text is available yet for this article.
November 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/29141720/prevalence-of-chlamydia-trachomatis-specific-antibodies-before-and-after-mass-drug-administration-for-trachoma-in-community-wide-surveys-of-four-communities-in-nepal
#3
Sarah E Gwyn, Lingwei Xiang, Ram Prasad Kandel, Deborah Dean, Manoj Gambhir, Diana L Martin
The target end date for the global elimination of trachoma as a public health problem is 2020. As countries begin the process for submitting their dossier for the validation of elimination of trachoma as a public health problem, strategies for post-validation surveillance must be considered. Seroprevalence of antibodies against antigens from the causative bacteria Chlamydia trachomatis (Ct) in young children has been shown to reflect trachomatous inflammation-follicular (TF) rates in both endemic and previously endemic settings...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29140407/targeted-treatment-of-yaws-with-household-contact-tracing-how-much-do-we-miss
#4
Louise Dyson, Michael Marks, Oliver M Crook, Oliver Sokana, Anthony W Solomon, Alex Bishop, David C W Mabey, T Déirdre Hollingsworth
Yaws is a disabling bacterial infection primarily found in warm and humid tropical areas. The World Health Organisation strategy mandates an initial round of total community treatment (TCT) with single-dose azithromycin followed either by further TCT or active case finding and treatment of cases and their contacts (the Morges strategy). We wish to investigate the effectiveness of the Morges strategy. We employ a stochastic household model to study the transmission of infection using data collected from a pre-TCT survey conducted in the Solomon Islands...
November 13, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29137663/patent-landscape-of-neglected-tropical-diseases-an-analysis-of-worldwide-patent-families
#5
Folahanmi Tomiwa Akinsolu, Vitor Nobre de Paiva, Samuel Santos Souza, Orsolya Varga
BACKGROUND: "Neglected Tropical Diseases" (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are "preventive chemotherapy and transmission control" (PCT), and "innovative and intensified disease management" (IDM). In the last 5 years, phenomenal progress has been achieved. However, it is crucial to intensify research effort into NTDs, because of the emerging drug resistance. According to the World Health Organization (WHO), the term NTDs covers 17 diseases, namely buruli ulcer, Chagas disease, dengue, dracunculiasis, echinococcosis, trematodiasis, human African trypanosomiasis, leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, rabies, schistosomiasis, soil-transmitted helminthes, taeniasis, trachoma, and yaws...
November 14, 2017: Globalization and Health
https://www.readbyqxmd.com/read/29125849/effect-of-water-sanitation-and-hygiene-interventions-on-active-trachoma-in-north-and-south-wollo-zones-of-amhara-region-ethiopia-a-quasi-experimental-study
#6
Beselam Tadesse, Alemayehu Worku, Abera Kumie, Solomon Abebe Yimer
BACKGROUND: Trachoma is chronic kerato conjunctivitis, which is caused by repeated infection with Chlamydia trachomatis bacterium. It is hyper endemic in many rural areas of Ethiopia. The objective of this study was to measure the effect of water, sanitation and hygiene interventions on active trachoma in selected woredas of North and South Wollo zones of Amhara Region, Ethiopia. METHODOLOGY: A community based quasi-experimental study was conducted from October 2014 to December 2015 among children aged 1-8 years at baseline and among one year older same children after intervention...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29118442/serology-reflects-a-decline-in-the-prevalence-of-trachoma-in-two-regions-of-the-gambia
#7
Stephanie J Migchelsen, Nuno Sepúlveda, Diana L Martin, Gretchen Cooley, Sarah Gwyn, Harry Pickering, Hassan Joof, Pateh Makalo, Robin Bailey, Sarah E Burr, David C W Mabey, Anthony W Solomon, Chrissy H Roberts
Trachoma is caused by Chlamydia trachomatis (Ct). It is targeted for global elimination as a public health problem. In 2014, a population-based cross-sectional study was performed in two previously trachoma-endemic areas of The Gambia. Participants of all ages from Lower River Region (LRR) (N = 1028) and Upper River Region (URR) (N = 840) underwent examination for trachoma and had blood collected for detection of antibodies against the Ct antigen Pgp3, by ELISA. Overall, 30 (1.6%) individuals had active trachoma; the prevalence in children aged 1-9 years was 3...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29070928/how-schools-can-help-to-build-healthy-productive-lives-free-of-trachoma
#8
Jaouad Hammou, Gardachew Tiruneh, Abebaw Kebede
No abstract text is available yet for this article.
2017: Community Eye Health
https://www.readbyqxmd.com/read/29056503/charles-dickens-trachoma-and-blindness-in-pre-victorian-england
#9
REVIEW
Curtis E Margo, Lynn E Harman
In the early 1820s a Yorkshire boarding school was devastated by an outbreak of blinding ophthalmia. The cause of the epidemic was - in all likelihood - trachoma, then known as Egyptian ophthalmia. The headmaster of the Yorkshire school, William Shaw, was sued for gross negligence by two families whose sons went blind during the outbreak. The epidemic and trial would play a role in creating one of literatures most notorious fictional characters. Eighteen years after the trial, Charles Dickens modeled the vile schoolmaster Wackford Squeers in Nicholas Nickleby after Shaw, whose reputation and career would later be ruined by his thinly disguised portrayal in the novel...
October 19, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29053275/thiazolino-2-pyridone-amide-isosteres-as-inhibitors-of-chlamydia-trachomatis-infectivity
#10
James A D Good, Martina Kulén, Jim Silver, K Syam Krishnan, Wael Bahnan, Carlos Núñez-Otero, Ingela Nilsson, Emma Wede, Esmee de Groot, Åsa Gylfe, Sven Bergström, Fredrik Almqvist
Chlamydia trachomatis is a global health burden due to its prevalence as a sexually transmitted disease and as the causative agent of the eye infection trachoma. We recently discovered 3-amido thiazolino 2-pyridones which attenuated C. trachomatis infectivity without affecting host cell or commensal bacteria viability. We present here the synthesis and evaluation of nonhydrolyzable amide isosteres based on this class, leading to highly potent 1,2,3-triazole based infectivity inhibitors (EC50 ≤ 20 nM).
November 3, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29045419/the-cost-of-mapping-trachoma-data-from-the-global-trachoma-mapping-project
#11
Guillaume Trotignon, Ellen Jones, Thomas Engels, Elena Schmidt, Deborah A McFarland, Colin K Macleod, Khaled Amer, Amadou A Bio, Ana Bakhtiari, Sarah Bovill, Amy H Doherty, Asad Aslam Khan, Mariamo Mbofana, Siobhain McCullagh, Tom Millar, Consity Mwale, Lisa A Rotondo, Angela Weaver, Rebecca Willis, Anthony W Solomon
BACKGROUND: The Global Trachoma Mapping Project (GTMP) was implemented with the aim of completing the baseline map of trachoma globally. Over 2.6 million people were examined in 1,546 districts across 29 countries between December 2012 and January 2016. The aim of the analysis was to estimate the unit cost and to identify the key cost drivers of trachoma prevalence surveys conducted as part of GTMP. METHODOLOGY AND PRINCIPAL FINDINGS: In-country and global support costs were obtained using GTMP financial records...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29016320/comparison-of-platforms-for-testing-antibody-responses-against-the-chlamydia-trachomatis-antigen-pgp3
#12
Sarah Gwyn, Gretchen Cooley, Brook Goodhew, Stephan Kohloff, Natalie Banniettis, Ryan Wiegand, Diana L Martin
Antibody responses to Chlamydia trachomatis (CT) antigens may be useful tools for surveillance of trachoma by estimating cumulative prevalence of infection within a population. Data were compared from three different platforms-multiplex bead array (MBA), enzyme-linked immunosorbent assay (ELISA), and lateral flow assay (LFA)-measuring antibody responses against the CT antigen protein plasmid gene product 3 (Pgp3). Sensitivity was defined as the proportion of specimens testing antibody positive from a set of dried blood spots from Tanzanian 1-9-year olds who were positive for CT nucleic acid of all nucleic acid amplification test (NAAT)-positive individuals (N = 103)...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28988540/the-burden-of-and-risk-factors-for-active-trachoma-in-the-north-and-south-wollo-zones-of-amhara-region-ethiopia-a-cross-sectional-study
#13
Beselam Tadesse, Alemayehu Worku, Abera Kumie, Solomon Abebe Yimer
BACKGROUND: Trachoma is a disease of the eye, caused by the bacteria Chlamydia trachomatis, which can lead to blindness if left untreated. Ethiopia is one of the most trachoma-affected countries in the world. The objective of this study was to determine the prevalence of and associated risk factors for active trachoma among children in selected woredas of North and South Wollo Zones in Amhara Region, Ethiopia. METHODS: This study was a community-based, cross-sectional study, which was conducted from October to December 2014 among children aged 1-8...
October 9, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28988539/prevalence-and-determinants-of-active-trachoma-among-preschool-aged-children-in-dembia-district-northwest-ethiopia
#14
Ayanaw Tsega Ferede, Abel Fekadu Dadi, Amare Tariku, Akilew Awoke Adane
BACKGROUND: Trachoma is an infectious eye disease caused by Chlamydia trachomatis, which is the leading infectious cause of blindness worldwide. In areas where trachoma is endemic, active trachoma is common among preschool-aged children, with varying magnitude. This study aimed to estimate the prevalence of active trachoma and associated risk factors among preschool-aged children in Dembia District, northwest Ethiopia. METHODS: A community-based cross-sectional survey was conducted among preschool-aged children of northwest Ethiopia...
October 9, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28973295/surveillance-surveys-for-reemergent-trachoma-in-formerly-endemic-districts-in-nepal-from-2-to-10-years-after-mass-drug-administration-cessation
#15
Sheila K West, Andrea I Zambrano, Shekhar Sharma, Sailesh K Mishra, Beatriz E Muñoz, Laura Dize, Kathryn Crowley, Charlotte A Gaydos, Lisa A Rotondo
Importance: To verify districts for elimination of blinding trachoma, the World Health Organization requires a population-based surveillance survey for follicular trachoma (TF) and trachomatous trichiasis (TT) 2 years after mass drug administration (MDA) activities have ceased. However, it is unknown if 2 years provides enough time to discover reemergence. Objective: To determine the prevalence of trachoma from surveys among 4 districts in Nepal (Dailekh, Dang, Surkhet, and Kanchanpur) that had surveillance intervals of 2, 4, 8, and 10 years, respectively, after cessation of MDA...
November 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28966918/immunofibrogenic-gene-expression-patterns-in-tanzanian-children-with-ocular-chlamydia-trachomatis-infection-active-trachoma-and-scarring-baseline-results-of-a-4-year-longitudinal-study
#16
Athumani M Ramadhani, Tamsyn Derrick, David Macleod, Patrick Massae, Tara Mtuy, David Jeffries, Chrissy H Roberts, Robin L Bailey, David C W Mabey, Martin J Holland, Matthew J Burton
Trachoma, caused by Chlamydia trachomatis, is the world's leading infectious cause of blindness and remains a significant public health problem. Much of trachomatous disease pathology is thought to be caused indirectly by host cellular and immune responses, however the immune response during active trachoma and how this initiates progressive scarring is not clearly understood. Defining protective vs. pathogenic immune response to C. trachomatis is important for vaccine design and evaluation. This study reports the baseline results of a longitudinal cohort of Tanzanian children, who were monitored for 4 years in order to determine the immunofibrogenic and infectious correlates of progressive scarring trachoma...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28937949/international-vision-care-issues-and-approaches
#17
Rohit C Khanna, Srinivas Marmamula, Gullapalli N Rao
Globally, 32.4 million individuals are blind and 191 million have moderate or severe visual impairment (MSVI); 80% of cases of blindness and MSVI are avoidable. However, great efforts are needed to tackle blindness and MSVI, as eye care in most places is delivered in isolation from and without significant integration with general health sectors. Success stories, including control of vitamin A deficiency, onchocerciasis, and trachoma, showed that global partnerships, multisectoral collaboration, public-private partnerships, corporate philanthropy, support from nongovernmental organizations-both local and international-and governments are responsible for the success of these programs...
September 15, 2017: Annual Review of Vision Science
https://www.readbyqxmd.com/read/28936049/prevalence-and-risk-factors-of-dry-eye-symptoms-in-a-saudi-arabian-population
#18
Abdulaziz A Alshamrani, Abdulwahab S Almousa, Abdulrahman A Almulhim, Abdullah A Alafaleq, Mohammed B Alosaimi, Abdulrahman M Alqahtani, Ammar M Almulhem, Mohammed A Alshamrani, Ahmad H Alhallafi, Ismail Z Alqahtani, Abdullah A Alshehri
BACKGROUND: The information about dry eye epidemiology in Saudi Arabia is few in literature. PURPOSE: To estimate the prevalence and identify determinants of dry eye symptoms (DES) in Al-Ahsa, Saudi Arabia. METHODS: Using a multi-stage proportionate sampling technique, Saudis of both genders from 6 urban and 4 rural Primary Health Care centers in Al-Ahsa were enrolled. They were interviewed to gather data on sociodemography, symptoms of dry eye, factors potentially related to dry eye, and chronic comorbidities...
April 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28932256/hamiltonian-analysis-of-subcritical-stochastic-epidemic-dynamics
#19
Lee Worden, Ira B Schwartz, Simone Bianco, Sarah F Ackley, Thomas M Lietman, Travis C Porco
We extend a technique of approximation of the long-term behavior of a supercritical stochastic epidemic model, using the WKB approximation and a Hamiltonian phase space, to the subcritical case. The limiting behavior of the model and approximation are qualitatively different in the subcritical case, requiring a novel analysis of the limiting behavior of the Hamiltonian system away from its deterministic subsystem. This yields a novel, general technique of approximation of the quasistationary distribution of stochastic epidemic and birth-death models and may lead to techniques for analysis of these models beyond the quasistationary distribution...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28926696/exposure-to-animal-feces-and-human-health-a-systematic-review-and-proposed-research-priorities
#20
Gauthami Penakalapati, Jenna Swarthout, Miranda J Delahoy, Lydia McAliley, Breanna Wodnik, Karen Levy, Matthew C Freeman
Humans can be exposed to pathogens from poorly managed animal feces, particularly in communities where animals live in close proximity to humans. This systematic review of peer-reviewed and gray literature examines the human health impacts of exposure to poorly managed animal feces transmitted via water, sanitation, and hygiene (WASH)-related pathways in low- and middle-income countries, where household livestock, small-scale animal operations, and free-roaming animals are common. We identify routes of contamination by animal feces, control measures to reduce human exposure, and propose research priorities for further inquiry...
October 17, 2017: Environmental Science & Technology
keyword
keyword
39928
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"