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https://www.readbyqxmd.com/read/28817680/human-alpha-defensin-5-is-a-candidate-biomarker-to-delineate-inflammatory-bowel-disease
#1
Amanda D Williams, Olga Y Korolkova, Amos M Sakwe, Timothy M Geiger, Samuel D James, Roberta L Muldoon, Alan J Herline, J Shawn Goodwin, Michael G Izban, Mary K Washington, Duane T Smoot, Billy R Ballard, Maria Gazouli, Amosy E M'Koma
Inability to distinguish Crohn's colitis from ulcerative colitis leads to the diagnosis of indeterminate colitis. This greatly effects medical and surgical care of the patient because treatments for the two diseases vary. Approximately 30 percent of inflammatory bowel disease patients cannot be accurately diagnosed, increasing their risk of inappropriate treatment. We sought to determine whether transcriptomic patterns could be used to develop diagnostic biomarker(s) to delineate inflammatory bowel disease more accurately...
2017: PloS One
https://www.readbyqxmd.com/read/28816111/updated-2014-stopp-criteria-to-identify-potentially-inappropriate-prescribing-in-community-dwelling-in-elderly-patients%C3%A2
#2
María Luisa Nicieza-Garcia, Gloria Manso, Esther Salgueiro
OBJECTIVE: To analyze potentially inappropriate prescribing (PIP) using the 2014 version of STOPP criteria. MATERIALS AND METHODS: Prescriptions were analyzed by using invoicing data and electronic medical records. RESULTS: At least one STOPP criterion was observed in 9 out of every 10 patients. The most common STOPP criteria found were: "any drug prescribed without an evidence-based clinical indication" and "any drug prescribed beyond the recommended duration, where treatment duration is well defined"...
August 17, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28815546/clusters-of-week-specific-maternal-gestational-weight-gain-pattern-and-their-association-with-birthweight-an-observational-cohort-study
#3
Huan Liang, Chuanmin Yin, Xinran Dong, Ganesh Acharya, Xiaotian Li
INTRODUCTION: Gestational weight gain (GWG) varies widely among different populations, and an inappropriate GWG is associated with adverse pregnancy outcomes. We aimed to investigate week-specific serial changes in GWG in an urban Chinese population to derive clusters of GWG pattern and explore the impact of GWG patterns on birthweight. MATERIAL AND METHODS: This was an observational cohort study of 6130 women delivered at a university hospital in Shanghai, China...
August 16, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28814126/detection-of-ingested-nitromethane-and-reliable-creatinine-assessment-using-multiple-common-analytical-methods
#4
Christine M Murphy, John J Devlin, Michael C Beuhler, Paul Cheifetz, Susan Maynard, Michael D Schwartz, Sherri Kacinko
AIM: Nitromethane, found in fuels used for short distance racing, model cars, and model airplanes, produces a falsely elevated serum creatinine with standard creatinine analysis via the Jaffé method. Erroneous creatinine elevation often triggers extensive testing, leads to inaccurate diagnoses, and delayed or inappropriate medical interventions. Multiple reports in the literature identify "enzymatic assays" as an alternative method to detect the true value of creatinine, but this ambiguity does not help providers translate what type of enzymatic assay testing can be done in real time to determine if there is indeed false elevation...
August 17, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28812924/susceptibility-testing-and-reporting-of-new-antibiotics-with-a-focus-on-tedizolid-an-international-working-group-report
#5
Mark H Wilcox, Natalia Dmitrieva, Ana Cristina Gales, Irina Petukhova, Suleiman Al-Obeid, Flavia Rossi, Joseph M Blondeau
Inappropriate use and overuse of antibiotics are among the most important factors in resistance development, and effective antibiotic stewardship measures are needed to optimize outcomes. Selection of appropriate antimicrobials relies on accurate and timely antimicrobial susceptibility testing. However, the availability of clinical breakpoints and in vitro susceptibility testing often lags behind regulatory approval by several years for new antimicrobials. A Working Group of clinical/medical microbiologists from Brazil, Canada, Mexico, Saudi Arabia, Russia and the UK recently examined issues surrounding antimicrobial susceptibility testing for novel antibiotics...
August 16, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28811395/overview-and-reflections-of-a-new-experimental-community-pharmacy-internship-module-for-undergraduate-pharmacy-students-in-western-nepal
#6
Sangita Timsina, Bhuvan K C, Dristi Adhikari, Alian A Alrasheedy, Mohamed Izham Mohamed Ibrahim, Atisammodavardhana Kaundinnyayana
The community pharmacies in Nepal and other South Asian countries is in a mediocre state due to poor regulation and the pharmacies being run by people with short training on dispensing. This has led to inappropriate use of medicines. The problem due to poor regulation and mediocre state of community pharmacies in South Asia encompasses both academia and practice. In this paper, the two-week community pharmacy internship programme of the two pharmacy graduating students of Pokhara University (Nepalese public university) at Sankalpa Pharmacy, Pokhara, Nepal is illustrated...
August 16, 2017: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/28809591/reducing-inappropriate-non-steroidal-anti-inflammatory-prescription-in-primary-care-patients-with-chronic-kidney-disease
#7
David M Keohane, Thomas Dennehy, Kenneth P Keohane, Eamonn Shanahan
Purpose The purpose of this paper is to reduce inappropriate non-steroidal anti-inflammatory prescribing in primary care patients with chronic kidney disease (CKD). Once diagnosed, CKD management involves delaying progression to end stage renal failure and preventing complications. It is well established that non-steroidal anti-inflammatories have a negative effect on kidney function and consequently, all nephrology consensus groups suggest avoiding this drug class in CKD. Design/methodology/approach The sampling criteria included all practice patients with a known CKD risk factor...
August 14, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28808489/what-should-be-the-appropriate-minimal-duration-for-patient-examination-and-evaluation-in-pulmonary-outpatient-clinics
#8
Benan Musellim, Sermin Borekci, Gulfidan Uzan, Zafer Hasan Ali Sak, Secil Kepil Ozdemir, Goksel Altinisik, Sinem Agca Altunbey, Nazan Sen, Oguz Kilinc, Arzu Yorgancioglu
INTRODUCTION: Patient examinations performed in a limited time period may lead to impairment in patient and physician relationship, defective and erroneous diagnosis, inappropriate prescriptions, less common use of preventive medicine practices, poor patient satisfaction, and increased violent acts against health-care staff. OBJECTIVE: This study aimed to determine the appropriate minimal duration of patient examination in the pulmonary practice. METHODS: A total of 49 researchers from ten different study groups of the Turkish Thoracic Society participated in the study...
July 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28807511/prevalence-and-predictors-of-inappropriate-anticoagulation-in-patients-with-a-cha2ds2-vasc-score-of-0-and-atrial-fibrillation
#9
Sepehr Saberian, Auroa Badin, Vince Siebert, Ashish Roy, Sandeep Banga, Harshavardhan R Ghadiam, Rebecca R Wigant, Ashim Aggarwal, Timir S Baman
BACKGROUND: Previous studies have shown underutilization of anticoagulation therapy in patients with atrial fibrillation and a CHA2DS2-VASc score ≥2; however there exists little data regarding the inappropriate use of anticoagulation in patients with a CHA2DS2-VASc score of 0. We aimed to determine the true prevalence and predictors of inappropriate anticoagulation therapy in patients with atrial fibrillation and a CHA2DS2-VASc score of 0. METHODS: A retrospective chart review was performed on all patients with atrial fibrillation and a CHA2DS2-VASc score of 0 in our institution from January 2009 to January 2016...
August 2, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28804870/effect-of-the-tool-to-reduce-inappropriate-medications-on-medication-communication-and-deprescribing
#10
Terri R Fried, Kristina M Niehoff, Richard L Street, Peter A Charpentier, Nallakkandi Rajeevan, Perry L Miller, Mary K Goldstein, John R O'Leary, Brenda T Fenton
OBJECTIVES: To examine the effect of the Tool to Reduce Inappropriate Medications (TRIM), a web tool linking an electronic health record (EHR) to a clinical decision support system, on medication communication and prescribing. DESIGN: Randomized clinical trial. SETTING: Primary care clinics at a Veterans Affairs Medical Center. PARTICIPANTS: Veterans aged 65 and older prescribed seven or more medications randomized to receipt of TRIM or usual care (N = 128)...
August 14, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28804862/oncological-patients-in-the-intensive-care-unit-prognosis-decision-making-therapies-and-end-of-life-care
#11
Ewelina Biskup, Fengfeng Cai, Marcus Vetter, Stephan Marsch
The effectiveness of intensive care unit (ICU) care for cancer patients remains controversial. Advances in antitumour and supportive care led to major improvements in outcomes of oncological patients in the ICU. Improved cancer therapies and supportive management of organ dysfunctions have contributed to improved survival rates. As a consequence, the number of cancer patients requiring ICU admission is rising. Frequently, cancer patients have a poor performance status and are vulnerable. It is a heterogeneous population, where the nature and curability of the neoplasm and the severity of critical illness cause a plethora of issues about ICU admissions...
August 14, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28804393/ageism-among-physicians-nurses-and-social-workers-findings-from-a-qualitative-study
#12
Aya Ben-Harush, Sharon Shiovitz-Ezra, Israel Doron, Sara Alon, Arthur Leibovitz, Hava Golander, Yafa Haron, Liat Ayalon
This study investigated ageism among healthcare professionals in various therapeutic settings in Israel. Using a qualitative approach, the current study aimed to examine similarities and differences across healthcare disciplines. Three focus groups were conducted with physicians, nurses, and social workers. Data from each focus group were analyzed separately, and then commonalities and differences across the groups were evaluated. Three main themes relating to older adults emerged from the data. The first theme pertains to perceived difficulties that healthcare professionals experience in working with older adults and their family members; the second focuses on invisibility and discriminatory communication patterns; and the third theme relates to provision of inappropriate care to older adults...
March 2017: European Journal of Ageing
https://www.readbyqxmd.com/read/28802348/alarm-safety-and-alarm-fatigue
#13
REVIEW
Kendall R Johnson, James I Hagadorn, David W Sink
Clinical alarm systems have received significant attention in recent years following warnings from hospital accrediting and health care technology organizations regarding patient harm caused by unsafe practices. Alarm desensitization or fatigue from frequent, false, or unnecessary alarms, has led to serious events and even patient deaths. Other concerns include settings inappropriate to patient population or condition, inadequate staff training, and improper use or disabling. Research on human factors in alarm response and of functionality of medical devices will help clinicians develop appropriate policies, practices, and device settings for clinical alarms in neonatal intensive care units...
September 2017: Clinics in Perinatology
https://www.readbyqxmd.com/read/28799226/educational-intervention-on-medication-reviews-aiming-to-reduce-acute-healthcare-consumption-in-elderly-patients-with-potentially-inappropriate-medicines-a-pragmatic-open-label-cluster-randomized-controlled-trial-in-primary-care
#14
K Schmidt-Mende, M Andersen, B Wettermark, J Hasselström
PURPOSE: Potentially inappropriate medicines (PIMs) may cause 10% of unplanned admissions in elderly people. We performed an educational intervention in primary care to reduce acute health care consumption and PIMs through the promotion of medication reviews (MRs) in elderly patients. METHODS: This cluster-randomized controlled trial was conducted in the context of an official campaign promoting rational drug use in elderly people. Sixty-nine primary health care practices with 119,910 patients aged older than or equal to 65 were randomized, with 1 dropout in the intervention group...
August 11, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28793120/functional-health-literacy-and-adherence-to-the-medication-in-older-adults-integrative-review
#15
Nidia Farias Fernandes Martins, Daiane Porto Gautério Abreu, Bárbara Tarouco da Silva, Deisa Salyse Dos Reis Cabral Semedo, Marlene Teda Pelzer, Fabiana Souza Ienczak
Objective: to characterize the national and international scientific production on the relationship of Functional Health Literacy and the adherence to the medication in older adults. Method: integrative review of literature, searching the following online databases: Scientific Electronic Library Online (SCIELO); Latin American and Caribbean Health Sciences Literature (LILACS); Medical Literature Analysis and Retrieval System Online (MEDLINE); and Cumulative Index to Nursing & Allied Health Literature (CINAHL), in June 2016...
July 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28792170/consensus-on-basal-insulin-in-the-management-of-type-2-diabetes-which-when-and-how
#16
Samit Ghosal, Binayak Sinha, Anirban Majumder, Ashok Kumar Das, Awadhesh Kumar Singh, Biswajit Ghoshdastidar, Debasish Maji, Ghanshyam Goyal, Jagat Jyoti Mukherjee, Kalyan Kumar Gangopadhyay, Mathew John, Sanjay Chatterjee, Shalini Jaggi, Subir Ray, Sujoy Majumdar, Surendra Kumar Sharma
INTRODUCTION: Type 2 diabetes mellitus (T2DM) has attained epidemic proportions and continues to increase despite the availability of a number of oral antidiabetic medications and major advances made in insulin delivery since its discovery nearly a hundred years ago. One, amongst many other reasons responsible for the inability to achieve adequate glycaemic control in a substantial proportion of T2DM patients is the delayed initiation and inappropriate intensification of insulin treatment...
July 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28781135/five-year-epidemiology-of-liquefied-petroleum-gas-related-burns
#17
Ronghua Jin, Pan Wu, Jon Kee Ho, Xingang Wang, Chunmao Han
BACKGROUND: The incidence of liquefied petroleum gas (LPG)-related burns has increased over recent years, and it has become a serious public health issue in developing countries such as India and Turkey. This paper aims to investigate the epidemiological characteristics of LPG-related burns to provide assistance and suggestions for planning prevention strategies. METHODS: A 5-year retrospective study was conducted in patients with LPG-related burns admitted to the Department of Burns & Wound Care Center, Second Affiliated Hospital of Zhejiang University, College of Medicine, between 1st January 2011 and 31st December 2015...
August 3, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28780910/drug-related-problems-in-community-dwelling-primary-care-patients-screened-positive-for-dementia
#18
D Wucherer, J R Thyrian, T Eichler, J Hertel, I Kilimann, S Richter, B Michalowsky, I Zwingmann, A Dreier-Wolfgramm, C A Ritter, S Teipel, W Hoffmann
BACKGROUND: Older people have a higher risk of drug-related problems (DRPs). However, little is known about the prevalence of DRPs in community-dwelling people who screened positive for dementia. Our study aimed to determine (1) the prevalence and types of DRPs and (2) the socio-demographic and clinical variables associated with DRPs in people screened positive for dementia in primary care. METHODS: The Dementia: life- and person-centered help in Mecklenburg-Western Pomerania (DelpHi-MV) study is a general practitioner (GP)-based cluster-randomized controlled intervention study to implement and evaluate an innovative concept of collaborative dementia care management in the primary care setting in Germany...
August 7, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28780525/medical-students-perceptions-of-professional-misconduct-relationship-with-typology-and-year-of-programme
#19
Juliana Zulkifli, Brad Noel, Deirdre Bennett, Siun O'Flynn, Colm O'Tuathaigh
AIM: To examine the contribution of programme year and demographic factors to medical students' perceptions of evidence-based classification categories of professional misconduct. METHODS: Students at an Irish medical school were administered a cross-sectional survey comprising 31 vignettes of professional misconduct, which mapped onto a 12-category classification system. Students scored each item using a 5-point Likert scale, where 1 represents the least severe form of misconduct and 5 the most severe...
August 5, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28779826/polypharmacy-and-medication-management-in-older-adults
#20
REVIEW
Jennifer Kim, Abby Luck Parish
Polypharmacy in older adults is a global problem that has recently worsened. Approximately 30% of adults aged 65 years and older in developed countries take 5 or more medications. Although prescribed and over-the-counter medications may improve a wide range of health problems, they also may cause or contribute to harm, especially in older adults. Polypharmacy in older adults is associated with worsening of geriatric syndromes and adverse drug events. Given the risks and burdens of polypharmacy and potentially inappropriate medications, nurses must use patient-centered approaches and nonpharmacologic strategies to treat common symptoms and to optimize patient function and quality of life...
September 2017: Nursing Clinics of North America
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