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https://www.readbyqxmd.com/read/29112302/tmd1-domain-and-crac-motif-determine-the-association-and-disassociation-of-mxirt1-with-detergent-resistant-membranes
#1
Song Tan, Peng Zhang, Wei Xiao, Bing Feng, Lan-You Chen, Shuang Li, Peng Li, Wei-Zhong Zhao, Xiao-Ting Qi, Li-Ping Yin
Iron is essential for most living organisms. The iron-regulated transporter1 (IRT1) plays a major role in iron uptake in roots, and its trafficking from endoplasmic reticulum (ER) to plasma membrane (PM) is tightly coordinated with changes in iron environment. However, studies on IRT1 response are limited. Here, we report that Malus xiaojinesis IRT1 (MxIRT1) associates with detergent-resistant membranes (DRMs, a biochemical counterpart of PM microdomains), whereas the PM microdomains are known platforms for signal transduction in the PM...
November 7, 2017: Traffic
https://www.readbyqxmd.com/read/29111371/pharmacodynamics-in-alzheimer-s-disease-model-rats-of-a-bifunctional-peptide-with-the-potential-to-accelerate-the-degradation-and-reduce-the-toxicity-of-amyloid-%C3%AE-cu-fibrils
#2
Dan Wang, Qian Zhang, Xiaoyu Hu, Wei Wang, Xushan Zhu, Zhi Yuan
The accumulation of the extracellular β-amyloid (Aβ) aggregates with metal ions in conjunction with reactive oxygen species (ROS) is closely related to the pathogenesis of Alzheimer's disease (AD). Accounting on Cu ions chelating of our previously designed bifunctional peptide GGHRYYAAFFARR (GR) as well as Aβ-Cu fibrils (fAβ-Cu) dissociation potentials, we report herein an efficient route to synthetically minimize ROS toxicity and degrade fAβ-Cu. It is worth mentioning that GR combines the metal chelating agent GGH and β-sheet breaker RYYAAFFARR (RR)...
October 27, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29108762/alveolar-microlithiasis-and-its-distinctive-clinical-and-radiological-disassociation
#3
Laura Cuesta Lujano, Álvaro Gutiérrez Domingo, Luis Fernández Ollero
No abstract text is available yet for this article.
November 3, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29097744/alleviative-effects-of-fluoxetine-on-depressive-like-behaviors-by-epigenetic-regulation-of-bdnf-gene-transcription-in-mouse-model-of-post-stroke-depression
#4
Hui-Juan Jin, Lei Pei, Ya-Nan Li, Hui Zheng, Shuai Yang, Yan Wan, Ling Mao, Yuan-Peng Xia, Quan-Wei He, Man Li, Zhen-Yu Yue, Bo Hu
Fluoxetine, one of the selective serotonin reuptake inhibitor (SSRI) antidepressants, has been thought to be effective for treating post-stroke depression (PSD). Recent work has shown that fluoxetine may exert an antidepressive effect through increasing the level of brain-derived neurotrophic factor (BDNF), but the underlying mechanism still remains unclear. In the present study, we successfully established the PSD model using male C57BL/6 J mice by photothrombosis of the left anterior cortex combined with isolatied-housing conditions...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29091765/low-grade-astrocytoma-mutations-in-idh1-p53-and-atrx-cooperate-to-block-differentiation-of-human-neural-stem-cells-via-repression-of-sox2
#5
Aram S Modrek, Danielle Golub, Themasap Khan, Devin Bready, Jod Prado, Christopher Bowman, Jingjing Deng, Guoan Zhang, Pedro P Rocha, Ramya Raviram, Charalampos Lazaris, James M Stafford, Gary LeRoy, Michael Kader, Joravar Dhaliwal, N Sumru Bayin, Joshua D Frenster, Jonathan Serrano, Luis Chiriboga, Rabaa Baitalmal, Gouri Nanjangud, Andrew S Chi, John G Golfinos, Jing Wang, Matthias A Karajannis, Richard A Bonneau, Danny Reinberg, Aristotelis Tsirigos, David Zagzag, Matija Snuderl, Jane A Skok, Thomas A Neubert, Dimitris G Placantonakis
Low-grade astrocytomas (LGAs) carry neomorphic mutations in isocitrate dehydrogenase (IDH) concurrently with P53 and ATRX loss. To model LGA formation, we introduced R132H IDH1, P53 shRNA, and ATRX shRNA into human neural stem cells (NSCs). These oncogenic hits blocked NSC differentiation, increased invasiveness in vivo, and led to a DNA methylation and transcriptional profile resembling IDH1 mutant human LGAs. The differentiation block was caused by transcriptional silencing of the transcription factor SOX2 secondary to disassociation of its promoter from a putative enhancer...
October 31, 2017: Cell Reports
https://www.readbyqxmd.com/read/29061846/a-transcriptional-coregulator-spin-doc-attenuates-the-coactivator-activity-of-spindlin1
#6
Narkhyun Bae, Min Gao, Xu Li, Tolkappiyan Premkumar, Gianluca Sbardella, Junjie Chen, Mark T Bedford
Spindlin1 (SPIN1) is a transcriptional coactivator with critical functions in embryonic development and emerging roles in cancer. SPIN1 harbors three Tudor domains, two of which engage the tail of histone H3 by reading the H3-Lys-4 trimethylation (H3K4me3) and H3-Arg-8 asymmetric dimethylation (H3R8me2a) marks. To gain mechanistic insight into how SPIN1 functions as a transcriptional coactivator, here we purified its interacting proteins. We identified an uncharacterized protein (C11orf84), which we renamed SPIN1 docking protein (SPIN-DOC), that directly binds SPIN1 and strongly disrupts its histone methylation reading ability, causing it to disassociate from chromatin...
October 23, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29058592/ureteral-reconstruction-using-a-tapered-non-vascularized-bladder-graft-an-experimental-study-in-a-canine-animal-model
#7
Lujia Zou, Shanhua Mao, Shenghua Liu, Limin Zhang, Tian Yang, Yun Hu, Qiang Ding, Haowen Jiang
BACKGROUND: Reconstruction of ureteral defects and strictures remains problematic for urologists. We aimed to investigate the possibility of a tapered non-vascularized bladder graft as a novel substitute for ureteral reconstruction. METHODS: This experimental study was conducted on nine beagles. Under general anesthesia, a full-thickness graft with 5-6 cm in length was disassociated from the anterior upper wall of the bladder, and tapered into 1/3 to 1/2 thickness, remaining the urothelial surface...
October 23, 2017: BMC Urology
https://www.readbyqxmd.com/read/29050336/transcriptional-downregulation-of-microrna-19a-by-ros-production-and-nf-%C3%AE%C2%BAb-deactivation-governs-resistance-to-oxidative-stress-initiated-apoptosis
#8
Jun Hong, Ying Wang, Bang-Chuan Hu, Liang Xu, Jing-Quan Liu, Min-Hua Chen, Jin-Zhu Wang, Fang Han, Yang Zheng, Xu Chen, Qian Li, Xiang-Hong Yang, Ren-Hua Sun, Shi-Jing Mo
Cell apoptosis is one of the main pathological alterations during oxidative stress (OS) injury. Previously, we corroborated that nuclear factor-κB (NF-κB) transactivation confers apoptosis resistance against OS in mammalian cells, yet the underlying mechanisms remain enigmatic. Here we report that microRNA-19a (miR-19a) transcriptionally regulated by reactive oxygen species (ROS) production and NF-κB deactivation prevents OS-initiated cell apoptosis through cylindromatosis (CYLD) repression. CYLD contributes to OS-initiated cell apoptosis, for which NF-κB deactivation is essential...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29035037/controlling-superwettability-by-microstructure-and-surface-energy-manipulation-on-three-dimensional-substrates-for-versatile-gravity-driven-oil-water-separation
#9
Hao-Yang Mi, Xin Jing, Han-Xiong Huang, Lih-Sheng Turng
Superwettable materials have gained tremendous attention because of their special wetting abilities. The key to obtaining and tuning superwettability is to precisely control the interfacial microstructures and surface energies of materials. Herein, we propose a novel approach to controlling the superwettability of three-dimensional foams. The surface microstructure was manipulated by the layer-by-layer covalent grafting of multidimensional nanoparticles (e.g., silica, carbon nanotubes, and graphene oxide), and the surface energy was tailored by grafting chemicals with different functional groups...
October 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29024529/catalytic-conductive-bipolar-membrane-interfaces-via-layer-by-layer-deposition-for-the-design-of-membrane-integrated-artificial-photosynthesis-systems
#10
Michael B McDonald, Michael Freund, Paula T Hammond
In the presence of an electric field, bipolar membranes (BPMs) are capable of initiating water disassociation (WD) within the interfacial region, which can make water splitting for renewable energy in the presence of a pH gradient possible. In addition to WD catalytic efficiency, there is also need for electronic conductivity in this region for membrane-integrated artificial photosynthesis (AP) systems. Graphene oxide (GO) has been shown to catalyze WD and to be controllably reduced resulting in electronic conductivity...
October 10, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28980690/rational-design-of-food-grade-polyelectrolyte-complex-coacervate-for-encapsulation-and-enhanced-oral-delivery-of-oenothein-b
#11
Yaqi Lan, Li Wang, Sufang Cao, Yinger Zhong, Yunqi Li, Yong Cao, Lichao Zhao
Oenothein B (OeB), a dimeric macrocyclic ellagitannin isolated from eucalyptus leaves has been demonstrated as a promising natural bioactive compound for its remarkable antitumor, antioxidant, anti-inflammatory and immunomodulating effects. Unfortunately, early study indicates that OeB has quite low bioaccessibility for oral consumption due to their susceptibility to decomposition both in vitro and in vivo. Herein, we report the design and synthesis of food-grade polyelectrolyte complex coacervate using caseinophosphopeptides (CPPs) and chitosan (CS) to encapsulate OeB for enhanced protection through gastrointestinal (GI) tract...
October 5, 2017: Food & Function
https://www.readbyqxmd.com/read/28977870/c-terminal-kinesin-motor-kifc1-participates-in-facilitating-proper-cell-division-of-human-seminoma
#12
Yu-Xi Xiao, Hao-Qing Shen, Zhen-Yu She, Li Sheng, Qian-Qian Chen, Yu-Lan Chu, Fu-Qing Tan, Wan-Xi Yang
C-terminus kinesin motor KIFC1 is known for centrosome clustering in cancer cells with supernumerary centrosomes. KIFC1 crosslinks and glides on microtubules (MT) to assist normal bipolar spindle formation to avoid multi-polar cell division, which might be fatal. Testis cancer is the most common human cancer among young men. However, the gene expression profiles of testis cancer is still not complete and the expression of the C-terminus kinesin motor KIFC1 in testis cancer has not yet been examined. We found that KIFC1 is enriched in seminoma tissues in both mRNA level and protein level, and is specifically enriched in the cells that divide actively...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976432/the-efficiency-of-bone-marrow-aspiration-for-the-harvest-of-connective-tissue-progenitors-from-the-human-iliac-crest
#13
Thomas E Patterson, Cynthia Boehm, Chizu Nakamoto, Richard Rozic, Esteban Walker, Nicolas S Piuzzi, George F Muschler
BACKGROUND: The rational design and optimization of tissue engineering strategies for cell-based therapy requires a baseline understanding of the concentration and prevalence of osteogenic progenitor cell populations in the source tissues. The aim of this study was to (1) define the efficiency of, and variation among individuals in, bone marrow aspiration as a means of osteogenic connective tissue progenitor (CTP-O) harvest compared with harvest from iliac cancellous bone, and (2) determine the location of CTP-Os within native cancellous bone and their distribution between the marrow-space and trabecular-surface tissue compartments...
October 4, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28975452/mathematical-modeling-for-estrogenic-activity-prediction-of-17%C3%AE-estradiol-and-17%C3%AE-ethynylestradiol-mixtures-in-wastewater-treatment-plants-effluent
#14
Yien Fang Ting, Sarva Mangala Praveena, Ahmad Zaharin Aris, Sharifah Norkhadijah Syed Ismail, Irniza Rasdi
Steroid estrogens such as 17β-Estradiol (E2) and 17α-Ethynylestradiol (EE2) are highly potent estrogens that widely detected in environmental samples. Mathematical modelling such as concentration addition (CA) and estradiol equivalent concentration (EEQ) models are usually associated with measuring techniques to assess risk, predict the mixture response and evaluate the estrogenic activity of mixture. Wastewater has played a crucial role because wastewater treatment plant (WWTP) is the major sources of estrogenic activity in aquatic environment...
October 3, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28973306/structure-based-investigation-on-the-binding-and-activation-of-typical-pesticides-with-thyroid-receptor
#15
Dandan Xiang, Jian Han, Tingting Yao, Qiangwei Wang, Bingsheng Zhou, Abou Donia Mohamed, Guonian Zhu
A broad range of pesticides have been reported to interfere with the normal function of the thyroid endocrine system. However, the precise mechanism(s) of action has not yet been thoroughly elucidated. In the present study, 21 pesticides were assessed for their binding interactions and the potential to disrupt thyroid homeostasis. In the GH3 luciferase reporter gene assays, 5 of the pesticides tested had agonistic effects in the order of procymidone > imidacloprid > mancozeb > fluroxypyr > atrazine...
August 31, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28973029/seasonal-variation-in-the-utility-of-a-status-signaling-system-plumage-ornament-predicts-foraging-success-only-during-periods-of-high-competition
#16
Philip S Queller, Troy G Murphy
Status signals allow competitors to assess each other's resource holding potential and reduce the occurrence of physical fights. Because status signals function to mediate competition over resources, a change in the strength of competition may affect the utility of a status signaling system. Status signals alter competitor behavior during periods of high competition, and thus determine access to resources; however, when competition is reduced, we expect these signals to become disassociated from access to resources...
2017: PloS One
https://www.readbyqxmd.com/read/28955982/therapeutic-potential-of-gw501516-and-the-role-of-peroxisome-proliferator-activated-receptor-%C3%AE-%C3%AE-and-b-cell-lymphoma-6-in-inflammatory-signaling-in-human-pancreatic-cancer-cells
#17
Russell W Smith, Jeffrey D Coleman, Jerry T Thompson, John P Vanden Heuvel
Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is a member of the nuclear receptor superfamily and a ligand-activated transcription factor that is involved in the regulation of the inflammatory response via activation of anti-inflammatory target genes and ligand-induced disassociation with the transcriptional repressor B-cell lymphoma 6 (BCL6). Chronic pancreatitis is considered to be a significant etiological factor for pancreatic cancer development, and a better understanding of the underlying mechanisms of the transition between inflammation and carcinogenesis would help further elucidate chemopreventative options...
December 2016: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28930995/stereotactic-atlas-guided-laser-capture-microdissection-of-brain-regions-affected-by-traumatic-injury
#18
Harris A Weisz, Deborah R Boone, Stacy L Sell, Helen L Hellmich
The ability to isolate specific brain regions of interest can be impeded in tissue disassociation techniques that do not preserve their spatial distribution. Such techniques also potentially skew gene expression analysis because the process itself can alter expression patterns in individual cells. Here we describe a laser capture microdissection (LCM) method to selectively collect specific brain regions affected by traumatic brain injury (TBI) by using a modified Nissl (cresyl violet) staining protocol and the guidance of a rat brain atlas...
September 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28916647/the-effect-of-common-inversion-polymorphisms-in-2l-t-and-in-3r-mo-on-patterns-of-transcriptional-variation-in-drosophila-melanogaster
#19
Erik Lavington, Andrew D Kern
Chromosomal inversions are a ubiquitous feature of genetic variation. Theoretical models describe several mechanisms by which inversions can drive adaptation and be maintained as polymorphisms. While inversions have been shown previously to be under selection, or contain genetic variation under selection, the specific phenotypic consequences of inversions leading to their maintenance remain unclear. Here we use genomic sequence and expression data from the Drosophila Genetic Reference Panel (DGRP) to explore the effects of two cosmopolitan inversions, In(2L)t and In(3R)Mo, on patterns of transcriptional variation...
November 6, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28890335/the-er-localized-transmembrane-protein-epg-3-vmp1-regulates-serca-activity-to-control-er-isolation-membrane-contacts-for-autophagosome-formation
#20
Yan G Zhao, Yong Chen, Guangyan Miao, Hongyu Zhao, Wenyan Qu, Dongfang Li, Zheng Wang, Nan Liu, Lin Li, She Chen, Pingsheng Liu, Du Feng, Hong Zhang
During autophagosome formation in mammalian cells, isolation membranes (IMs; autophagosome precursors) dynamically contact the ER. Here, we demonstrated that the ER-localized metazoan-specific autophagy protein EPG-3/VMP1 controls ER-IM contacts. Loss of VMP1 causes stable association of IMs with the ER, thus blocking autophagosome formation. Interaction of WIPI2 with the ULK1/FIP200 complex and PI(3)P contributes to the formation of ER-IM contacts, and these interactions are enhanced by VMP1 depletion. VMP1 controls contact formation by promoting SERCA (sarco[endo]plasmic reticulum calcium ATPase) activity...
September 21, 2017: Molecular Cell
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