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https://www.readbyqxmd.com/read/27899394/stress-activated-kinase-mkk7-governs-epigenetics-of-cardiac-repolarization-for-arrhythmia-prevention
#1
Sanjoy K Chowdhury, Wei Liu, Min Zi, Yatong Li, Shunyao Wang, Hoyee Tsui, Sukhpal Prehar, Simon J Castro, Henggui Zhang, Yong Ji, Xiuqin Zhang, Rui-Ping Xiao, Rongli Zhang, Ming Lei, Lukas Cyganek, Kaomei Guan, Catherine B Millar, Xudong Liao, Mukesh K Jain, Mark R Boyett, Elizabeth J Cartwright, Holly A Shiels, Xin Wang
BACKGROUND: -Ventricular arrhythmia is a leading cause of cardiac mortality. Most antiarrhythmics present paradoxical pro-arrhythmic side effects, culminating in a greater risk of sudden death. METHODS: -We describe a new regulatory mechanism linking mitogen-activated kinase kinase-7 (MKK7) deficiency with increased arrhythmia vulnerability in hypertrophied and failing hearts using mouse models harbouring MKK7 knockout or overexpression. The human relevance of this arrhythmogenic mechanism is evaluated in human induced pluripotent stem cells-derived cardiomyocytes (iPSC-CMs)...
November 29, 2016: Circulation
https://www.readbyqxmd.com/read/27893218/measuring-response-styles-in-likert-items
#2
Ulf Böckenholt
The recently proposed class of item response tree models provides a flexible framework for modeling multiple response processes. This feature is particularly attractive for understanding how response styles may affect answers to attitudinal questions. Facilitating the disassociation of response styles and attitudinal traits, item response tree models can provide powerful process tests of how different response formats may affect the measurement of substantive traits. In an empirical study, 3 response formats were used to measure the 2-dimensional Personal Need for Structure traits...
November 28, 2016: Psychological Methods
https://www.readbyqxmd.com/read/27847360/parvovirus-capsid-structures-required-for-infection-mutations-controlling-receptor-recognition-and-protease-cleavages
#3
Heather M Callaway, Kurtis H Feng, Donald W Lee, Andrew B Allison, Melissa Pinard, Robert McKenna, Mavis Agbandje-McKenna, Susan Hafenstein, Colin R Parrish
: Parvovirus capsids are small but complex molecular machines responsible for undertaking many of the steps of cell infection, genome packing, and cell-to-cell as well as host-to-host transfer. The details of parvovirus infection of cells are still not fully understood, but the processes must involve small changes in the capsid structure that allow the endocytosed virus to escape from the endosome, pass through the cell cytoplasm, and deliver the ssDNA genome to the nucleus where viral replication occurs...
November 9, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27829411/-i-wish-someone-watched-me-interview-medical-student-insight-into-observation-and-feedback-as-a-method-for-teaching-communication-skills-during-the-clinical-years
#4
Heather Schopper, Marcy Rosenbaum, Rick Axelson
BACKGROUND: Experts suggest observation and feedback is a useful tool for teaching and evaluating medical student communication skills during the clinical years. Failing to do this effectively risks contributing to deterioration of students' communication skills during the very educational period in which they are most important. While educators have been queried about their thoughts on this issue, little is known about what this process is like for learners and if they feel they get educational value from being observed...
November 9, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27821763/design-of-a-molecular-support-for-cryo-em-structure-determination
#5
Thomas G Martin, Tanmay A M Bharat, Andreas C Joerger, Xiao-Chen Bai, Florian Praetorius, Alan R Fersht, Hendrik Dietz, Sjors H W Scheres
Despite the recent rapid progress in cryo-electron microscopy (cryo-EM), there still exist ample opportunities for improvement in sample preparation. Macromolecular complexes may disassociate or adopt nonrandom orientations against the extended air-water interface that exists for a short time before the sample is frozen. We designed a hollow support structure using 3D DNA origami to protect complexes from the detrimental effects of cryo-EM sample preparation. For a first proof-of-principle, we concentrated on the transcription factor p53, which binds to specific DNA sequences on double-stranded DNA...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27802571/aquerium-a-web-application-for-comparative-exploration-of-domain-based-protein-occurrences-on-the-taxonomically-clustered-genome-tree
#6
Ogun Adebali, Igor B Zhulin
Gene duplication and loss are major driving forces in evolution. While many important genomic resources provide information on gene presence, there is a lack of tools giving equal importance to presence and absence information as well as web platforms enabling easy visual comparison of multiple domain-based protein occurrences at once. Here, we present Aquerium, a platform for visualizing genomic presence and absence of biomolecules with a focus on protein domain architectures. The web server offers advanced domain organization querying against the database of pre-computed domains for ∼26,000 organisms and it can be utilized for identification of evolutionary events, such as fusion, disassociation, duplication, and shuffling of protein domains...
November 1, 2016: Proteins
https://www.readbyqxmd.com/read/27795702/motor-imagery-classification-using-mu-and-beta-rhythms-of-eeg-with-strong-uncorrelating-transform-based-complex-common-spatial-patterns
#7
Youngjoo Kim, Jiwoo Ryu, Ko Keun Kim, Clive C Took, Danilo P Mandic, Cheolsoo Park
Recent studies have demonstrated the disassociation between the mu and beta rhythms of electroencephalogram (EEG) during motor imagery tasks. The proposed algorithm in this paper uses a fully data-driven multivariate empirical mode decomposition (MEMD) in order to obtain the mu and beta rhythms from the nonlinear EEG signals. Then, the strong uncorrelating transform complex common spatial patterns (SUTCCSP) algorithm is applied to the rhythms so that the complex data, constructed with the mu and beta rhythms, becomes uncorrelated and its pseudocovariance provides supplementary power difference information between the two rhythms...
2016: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/27771715/er-stress-via-chop-pathway-is-involved-in-fk506-induced-apoptosis-in-rat-fibroblasts
#8
Jian Tang, Yingbin Ge, Lei Yang, Xinyu Xu, Tao Sui, Dawei Ge, Jun Que, Xiaojian Cao
BACKGROUND/AIMS: Hypertrophic scars (HS) formation results from reduced apoptosis and increased proliferation of fibroblasts. Therefore, apoptosis of fibroblasts is a key target for the development of novel therapeutic strategies for HS. Previous reports demonstrated that FK506 could attenuate scar formation in vivo and FK506 could also induce endoplasmic reticulum stress (ER stress). However, the effects of FK506 on ER stress-mediated apoptosis in fibroblasts remain unclear. METHODS: Rat skin fibroblasts were used in the study...
October 24, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27765863/characterization-of-11c-gsk1482160-for-targeting-the-p2x7-receptor-as-a-biomarker-for-neuroinflammation
#9
Paul R Territo, Jill A Meyer, Jonathan S Peters, Amanda A Riley, Brian P McCarthy, Mingzhang Gao, Min Wang, Mark A Green, Qi-Huang Zheng, Gary D Hutchins
BACKGROUND: The P2X7 receptor represents a novel molecular target for imaging neuroinflammation via PET. GSK1482160, a potent P2X7 receptor antagonist, has high receptor affinity, blood-brain barrier penetration, and has been recently radiolabel ((11)C-GSK1482160). Therefore, we report the initial physical and biological characterization of this novel ligand. METHODS: (11)C-GSK1482160 synthesis was according to published methods. Cell density studies were performed in human embryonic kidney cell lines expressing human P2X7 receptors (HEK293-hP2X7R) and analyzed by western blot analysis, immuno-fluorescence assay (IFA), and radiologic-immunohistochemistry (RIHC) using P2X7R polyclonal antibodies...
October 20, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27739609/disassociation-between-brain-activation-and-executive-function-in-fragile-x-premutation-females
#10
Annie L Shelton, Kim Cornish, Meaghan Clough, Sanuji Gajamange, Scott Kolbe, Joanne Fielding
Executive dysfunction has been demonstrated among premutation (PM) carriers (55-199 CGG repeats) of the Fragile X mental retardation 1 (FMR1) gene. Further, alterations to neural activation patterns have been reported during memory and comparison based functional magnetic resonance imaging (fMRI) tasks in these carriers. For the first time, the relationships between fMRI neural activation during an interleaved ocular motor prosaccade/antisaccade paradigm, and concurrent task performance (saccade measures of latency, accuracy and error rate) in PM females were examined...
October 14, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27733607/stimulation-of-ppc-affects-the-mapping-between-motion-and-force-signals-for-stiffness-perception-but-not-motion-control
#11
Raz Leib, Firas Mawase, Amir Karniel, Opher Donchin, John Rothwell, Ilana Nisky, Marco Davare
: How motion and sensory inputs are combined to assess an object's stiffness is still unknown. Here, we provide evidence for the existence of a stiffness estimator in the human posterior parietal cortex (PPC). We showed previously that delaying force feedback with respect to motion when interacting with an object caused participants to underestimate its stiffness. We found that applying theta-burst transcranial magnetic stimulation (TMS) over the PPC, but not the dorsal premotor cortex, enhances this effect without affecting movement control...
October 12, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27716985/d-tyrosine-affects-aggregation-behavior-of-pantoea-agglomerans
#12
Jing Yang, Jiajia Yu, Jing Jiang, Chen Liang, Yongjun Feng
D-amino acids have been proved to disassemble biofilms by disassociating the matrix. Pantoea agglomerans is characterized by the formation of another kind of multicellular structure called symplasmata, which also remains the ability to form biofilms. In this study, a rice diazotrophic endophyte P. agglomerans YS19 was selected as a model strain to explore the effects of D-amino acids on these two kinds of cell aggregate structures. It was discovered that D-tyrosine disassociates biofilm, yet promotes symplasmata formation...
September 22, 2016: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/27697301/-is-there-a-disassociation-of-ventilatory-and-electromyographic-thresholds-in-patients-with-heart-disease-during-a-graded-cycling-exercise
#13
P-M Leprêtre, M Ghannem, S Delanaud, T Porcher, A Barnabé, L Gaillard, N Jaunet, T Weissland
: Exercise prescription was generally based on the determination of ventilatory thresholds (VT1, VT2) during cardiopulmonary exercise testing (CPX). Changes in surface electromyographic activity (EMGth1, EMGth2) were also related to VT1 and VT2 in healthy subjects. OBJECTIVE: To observe the occurrence of EMGth1 and EMGth2 and whether these events accompany VT1 and VT2 during CPX in cardiac patients (CP). METHOD: Thirty-four CP (62.1±7.3years, 172...
September 30, 2016: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/27686203/-research-misconduct-knowledge-actions-and-attitudes-of-phd-candidates
#14
Bjørn Hofmann, Søren Holm
BACKGROUND Increasing attention is being paid to research misconduct in academic journals and in the media, but we know relatively little about its extent or attitudes to research misconduct, or how these are changing. This study therefore aims to investigate PhD candidates' knowledge, own actions and attitudes to specific forms of research misconduct.MATERIAL AND METHOD In autumn 2015, an anonymous questionnaire survey was distributed to all participants in the introductory course for PhD candidates at the Faculty of Medicine at the University of Oslo...
September 2016: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/27683058/near-membrane-electric-field-calcium-ion-dehydration
#15
James P Barger, Patrick F Dillon
The dehydration of ion-water complexes prior to ion channel transit has focused on channel protein-mediated dissociation of water. Ion dehydration by the membrane electric field has not previously been considered. Near membrane electric fields have previously been shown to cause the disassociation of non-covalently bound small molecule-small molecule, small molecule-protein, and protein-protein complexes. It is well known that cosmotropic, structure making ions such as calcium and sodium significantly bind multiple water ions in solution...
September 22, 2016: Cell Calcium
https://www.readbyqxmd.com/read/27679653/the-arabidopsis-cerk1-associated-kinase-pbl27-connects-chitin-perception-to-mapk-activation
#16
Kenta Yamada, Koji Yamaguchi, Tomomi Shirakawa, Hirofumi Nakagami, Akira Mine, Kazuya Ishikawa, Masayuki Fujiwara, Mari Narusaka, Yoshihiro Narusaka, Kazuya Ichimura, Yuka Kobayashi, Hidenori Matsui, Yuko Nomura, Mika Nomoto, Yasuomi Tada, Yoichiro Fukao, Tamo Fukamizo, Kenichi Tsuda, Ken Shirasu, Naoto Shibuya, Tsutomu Kawasaki
Perception of microbe-associated molecular patterns by host cell surface pattern recognition receptors (PRRs) triggers the intracellular activation of mitogen-activated protein kinase (MAPK) cascades. However, it is not known how PRRs transmit immune signals to MAPK cascades in plants. Here, we identify a complete phospho-signaling transduction pathway from PRR-mediated pathogen recognition to MAPK activation in plants. We found that the receptor-like cytoplasmic kinase PBL27 connects the chitin receptor complex CERK1-LYK5 and a MAPK cascade...
November 15, 2016: EMBO Journal
https://www.readbyqxmd.com/read/27661403/driving-under-the-influence-of-distraction-examining-dissociations-between-risk-perception-and-engagement-in-distracted-driving
#17
Michael A Rupp, Marc D Gentzler, Janan A Smither
Driving while distracted is a critical and unwavering problem in the United States leading to numerous injuries and fatalities each year. While increasing legislation and developing technological interventions strive to ensure we only focus on driving, individuals still drive distracted. We surveyed college-aged adults to examine the factors that influence both their risk perception of driving while distracted and how often they engage in distracting activities and situations while driving. We found a disassociation between individuals' perception of driving distraction risk and their engagement with the distraction...
September 20, 2016: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/27636127/dynamic-electrochemical-control-of-cell-capture-and-release-based-on-redox-controlled-host-guest-interactions
#18
Tao Gao, Liudi Li, Bei Wang, Jun Zhi, Yang Xiang, Genxi Li
Artificial control of cell adhesion on smart surface is an on-demand technique in areas ranging from tissue engineering, stem cell differentiation, to the design of cell-based diagnostic system. In this paper, we report an electrochemical system for dynamic control of cell catch-and-release, which is based on the redox-controlled host-guest interaction. Experimental results reveal that the interaction between guest molecule (ferrocene, Fc) and host molecule (β-cyclodextrin, β-CD) is highly sensitive to electrochemical stimulus...
October 18, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27624796/heterokairy-a-significant-form-of-developmental-plasticity
#19
REVIEW
S D Rundle, J I Spicer
There is a current surge of research interest in the potential role of developmental plasticity in adaptation and evolution. Here we make a case that some of this research effort should explore the adaptive significance of heterokairy, a specific type of plasticity that describes environmentally driven, altered timing of development within a species. This emphasis seems warranted given the pervasive occurrence of heterochrony, altered developmental timing between species, in evolution. We briefly review studies investigating heterochrony within an adaptive context across animal taxa, including examples that explore links between heterokairy and heterochrony...
September 2016: Biology Letters
https://www.readbyqxmd.com/read/27618665/structural-insights-into-the-association-of-hif1-with-histones-h2a-h2b-dimer-and-h3-h4-tetramer
#20
Mengying Zhang, Hejun Liu, Yongxiang Gao, Zhongliang Zhu, Zijun Chen, Peiyi Zheng, Lu Xue, Jixi Li, Maikun Teng, Liwen Niu
Histone chaperones are critical for guiding specific post-transcriptional modifications of histones, safeguarding the histone deposition (or disassociation) of nucleosome (dis)assembly, and regulating chromatin structures to change gene activities. HAT1-interacting factor 1 (Hif1) has been reported to be an H3-H4 chaperone and to be involved in telomeric silencing and nucleosome (dis)assembly. However, the structural basis for the interaction of Hif1 with histones remains unknown. Here, we report the complex structure of Hif1 binding to H2A-H2B for uncovering the chaperone specificities of Hif1 on binding to both the H2A-H2B dimer and the H3-H4 tetramer...
October 4, 2016: Structure
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