keyword
https://read.qxmd.com/read/37680158/role-of-vitamin-d-in-management-of-diabetes-and-unresolved-cardiovascular-diseases
#21
JOURNAL ARTICLE
Prabhat Kumar Upadhyay, Navneet Thakur, Vishal Kumar Vishwakarma, Ritesh Kumar Srivastav, Tarique Mahmood Ansari
BACKGROUND: Vitamin D deficiency is becoming a widely recognized global health issue. Serum values of 25(OH) vitamin D (<20 ng/ml) are used to identify vitamin D deficiency. By prompting vascular endothelial cells to activate their nuclear receptor in cardio-myocytes, Vitamin D regulates obesity, Renin-angiotensin system (RAS), energy consumption, and pancreatic cell function. Vitamin D deficiency has been associated with diabetes, asthma, hyperlipidaemia, and pulmonary hypertension in humans...
September 1, 2023: Current Diabetes Reviews
https://read.qxmd.com/read/37664747/betulin-rich-hydroalcoholic-extract-of-daphne-oleoides-attenuates-bleomycin-induced-pulmonary-fibrosis-in-rat
#22
JOURNAL ARTICLE
Nazanin Danaei, Heibatollah Sadeghi, Arash Asfarm, Davoud Rostamzadeh, Esmaeel Panahi Kokhdan, Hossein Sadeghi, Negin Rahimi
BACKGROUND AND OBJECTIVE: Pulmonary fibrosis (PF) is a chronic and progressive respiratory disease representing the final stage of lung inflammatory disorders. Reactive oxygen species (ROS), an essential factor in the formation and progression of pulmonary fibrosis, are a significant adverse effect of Bleomycin (BLM). Antioxidant activities have been found in Daphne oleoides . In this study, we attempted to explore the function of hydroalcoholic extract of Daphne oleoides ( D. oleoides ) and Betulin in inhibiting bleomycin (BLM)-induced pulmonary fibrosis in rat"...
August 2023: Heliyon
https://read.qxmd.com/read/37605849/molecular-insights-using-spatial-transcriptomics-of-the-distal-lung-in-congenital-diaphragmatic-hernia
#23
JOURNAL ARTICLE
Krithika Lingappan, Oluyinka O Olutoye, Abiud Cantu, Manuel Eliezer Cantu Gutierrez, Nahir Cortes-Santiago, J D Hammond, Jamie Gilley, Joselyn Rojas Quintero, Hui Li, Francesca Polverino, Jason P Gleghorn, Sundeep G Keswani
Abnormal pulmonary vascular development and function in congenital diaphragmatic hernia (CDH) is a significant factor leading to pulmonary hypertension. The lung has marked cellular diversity that is differentially responsive to injury and therapeutic agents. Spatial transcriptomics provides unmatched capability of discerning the differences in the transcriptional signature of these distinct cell subpopulations in the lung with regional specificity. We hypothesized that the distal lung parenchyma (selected as a region of interest) would show a distinct transcriptomic profile in the CDH lung compared to control (normal lung)...
August 22, 2023: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://read.qxmd.com/read/37425312/association-of-amino-acids-and-parameters-of-bone-metabolism-with-endothelial-dysfunction-and-vasculopathic-changes-in-limited-systemic-sclerosis
#24
JOURNAL ARTICLE
Philipp Jud, Andreas Meinitzer, Heimo Strohmaier, Behrouz Arefnia, Gernot Wimmer, Barbara Obermayer-Pietsch, Vasile Foris, Gabor Kovacs, Balazs Odler, Florentine Moazedi-Fürst, Marianne Brodmann, Franz Hafner
OBJECTIVES: Pathways contributing to endothelial dysfunction in patients with limited cutaneous systemic sclerosis (lcSSc) are largely unknown. The aim of this study was to investigate potential associations of amino acids and parameters of bone metabolism with endothelial dysfunction and vasculopathy-related changes in patients with lcSSc and early-stage vasculopathy. METHODS: Amino acids, calciotropic parameters, including 25-hydroxyvitamin D and parathyroid hormone (PTH), and bone turnover parameters, including osteocalcin and N-terminal peptide of procollagen-3 (P3NP), were measured in 38 lcSSc patients and 38 controls...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37407930/vitamin-d-receptor-and-vitamin-d-binding-protein-gene-polymorphisms-in-patients-with-asthma-a-pilot-study
#25
JOURNAL ARTICLE
Bastyte Daina, Tamasauskiene Laura, Golubickaite Ieva, Ugenskiene Rasa, Sitkauskiene Brigita
BACKGROUND: The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D binding protein (VDBP). Polymorphisms in VDR or VDBP genes may affect vitamin D levels, influencing the pathogenesis of asthma and atopy. The aim of this study was to investigate the possible association of VDR and VDBP gene single-nucleotide polymorphisms (SNP), 25-hydroxyvitamin D (25(OH)D), blood eosinophils and total IgE level in subjects with asthma in comparison with healthy individuals...
July 5, 2023: BMC Pulmonary Medicine
https://read.qxmd.com/read/37304132/identification-of-potential-biomarkers-to-predict-organ-morbidity-in-covid-19-a-repository-based-proteomics-perspective
#26
JOURNAL ARTICLE
Sabyasachi Bandyopadhyay, Madhan Vishal Rajan, Punit Kaur, Gururao Hariprasad
SARS-CoV-2 causes substantial extrapulmonary manifestations in addition to pulmonary disease. Some of the major organs affected are cardiovascular, hematological and thrombotic, renal, neurological, and digestive systems. These types of muti-organ dysfunctions make it difficult and challenging for clinicians to manage and treat COVID-19 patients. The article focuses to identify potential protein biomarkers that can flag various organ systems affected in COVID-19. Publicly reposited high throughput proteomic data from human serum (HS), HEK293T/17 (HEK) and Vero E6 (VE) kidney cell culture were downloaded from ProteomeXchange consortium...
September 2023: Biochemistry and Biophysics Reports
https://read.qxmd.com/read/37276815/plasma-vitamin-d-levels-in-correlation-with-circulatory-proteins-could-be-a-potential-biomarker-tool-for-pulmonary-tuberculosis-and-treatment-monitoring
#27
JOURNAL ARTICLE
Kadar Moideen, Pavan Kumar Nathella, Seshacharyulu Madabushi, Rachel Mariam Renji, Padmanaban Srinivasan, Shaik Fayaz Ahamed, Hemalatha Rajkumar, Ramalingam Bethunaickan, Subash Babu
BACKGROUND: Tuberculosis (TB), a life-threatening immune challenging disease to the global human community has to be diagnosed earlier and eliminated in the upcoming era. Vitamin D, a fat-soluble micronutrient, mainly from epidermal cells of the skin and a few dietary sources, is associated with the immune system in various disease management. Therefore, a better understanding of vitamin D metabolism and immune function in tuberculosis should be studied for the consideration of biomarkers...
August 2023: Cytokine
https://read.qxmd.com/read/37186612/plasma-sterols-and-vitamin-d-are-correlates-and-predictors-of-ozone-induced-inflammation-in-the-lung-a-pilot-study
#28
JOURNAL ARTICLE
Alexia N Perryman, Hye-Young H Kim, Alexis Payton, Julia E Rager, Erin E McNell, Meghan E Rebuli, Heather Wells, Martha Almond, Jamie Antinori, Neil E Alexis, Ned A Porter, Ilona Jaspers
BACKGROUND: Ozone (O3) exposure causes respiratory effects including lung function decrements, increased lung permeability, and airway inflammation. Additionally, baseline metabolic state can predispose individuals to adverse health effects from O3. For this reason, we conducted an exploratory study to examine the effect of O3 exposure on derivatives of cholesterol biosynthesis: sterols, oxysterols, and secosteroid (25-hydroxyvitamin D) not only in the lung, but also in circulation. METHODS: We obtained plasma and induced sputum samples from non-asthmatic (n = 12) and asthmatic (n = 12) adult volunteers 6 hours following exposure to 0...
2023: PloS One
https://read.qxmd.com/read/37049536/immunomodulatory-properties-of-vitamin-d-in-the-intestinal-and-respiratory-systems
#29
REVIEW
Fatheia N Hamza, Sarah Daher, Hana M A Fakhoury, William B Grant, Peter R Kvietys, Khaled Al-Kattan
Vitamin D plays a crucial role in modulating the innate immune response by interacting with its intracellular receptor, VDR. In this review, we address vitamin D/VDR signaling and how it contributes to the regulation of intestinal and respiratory microbiota. We additionally review some components of the innate immune system, such as the barrier function of the pulmonary and intestinal epithelial membranes and secretion of mucus, with their respective modulation by vitamin D. We also explore the mechanisms by which this vitamin D/VDR signaling mounts an antimicrobial response through the transduction of microbial signals and the production of antimicrobial peptides that constitute one of the body's first lines of defense against pathogens...
March 30, 2023: Nutrients
https://read.qxmd.com/read/37030152/age-related-changes-in-vitamin-d-metabolism-and-vitamin-d-receptor-expression-in-equine-alveolar-macrophages-a-preliminary-study
#30
JOURNAL ARTICLE
L J Berghaus, J Cathcart, R D Berghaus, K A Hart
The vitamin D receptor (VDR)-vitamin D axis modulates pulmonary immunity in people but its role in equine immunity is unknown. Bacterial pneumonia causes high morbidity/mortality in foals and alveolar macrophages (AMφ) are important for pulmonary defenses. Age-related variations in vitamin D-mediated function of AMφ might contribute to the foal's susceptibility to pneumonia. Our aim was to assess the impact of age on equine vitamin D metabolism and VDR expression in AMφ. AMφ and plasma was collected from healthy foals (2, 4 and 8 weeks old) and adult horses (once)...
April 5, 2023: Veterinary Immunology and Immunopathology
https://read.qxmd.com/read/37008007/the-correlation-between-a-th1-th2-cytokines-imbalance-and-vitamin-d-level-in-patients-with-early-chronic-obstructive-pulmonary-disease-copd-based-on-screening-results
#31
JOURNAL ARTICLE
Wenhui Tang, Yan Rong, Hongmei Zhang, Zi'e Zhan, Long Yuan, Yan Ning, Wenji Lin
Objective: This study explored the correlation between a Th1/Th2 cytokines imbalance and 25-hydroxy-vitamin D (vit D) level in early chronic obstructive pulmonary disease (COPD), provided experimental rationales for the role of vit D in the prevention and control of COPD, and elucidated the potential anti-inflammatory mechanism involved. Methods: This study was based on the results of the "Screening and Early Diagnosis of COPD" public health project conducted through Shenzhen Municipal Qianhai Shekou Free Trade Zone Hospital...
2023: Frontiers in Physiology
https://read.qxmd.com/read/36999853/role-of-vitamin-d3-in-selected-pulmonary-diseases-with-particular-emphasis-on-lung-fibrosis
#32
REVIEW
Michał Chojnacki, Marta Kinga Lemieszek
INTRODUCTION AND OBJECTIVE: For many years vitamin D3 was known only as a regulator of the calcium-phosphate and water-electrolyte balances. Recent studies have paid special attention to other biological effects of calcitriol (the bioactive form of vitamin D3) with particular emphasis on its influence on immune function. Thus, any alterations, especially deficiencies, in the physiological level of calcitriol have serious health consequences. The aim of the study was to summarise the current state of knowledge concerning the role of vitamin D3 in selected pulmonary diseases...
March 31, 2023: Annals of Agricultural and Environmental Medicine: AAEM
https://read.qxmd.com/read/36966750/the-interplay-between-hypovitaminosis-d-and-the-immune-dysfunction-in-the-arteriovenous-thrombotic-complications-of-the-sever-coronavirus-disease-2019-covid-19-infection
#33
REVIEW
Haifa M AlNafea, Aida A Korish
Thromboembolic complications including cerebrovascular accidents, pulmonary embolism, myocardial infarction, deep vein thrombosis and disseminating intravascular coagulopathy are serious encounters in sever coronavirus disease 2019 (COVID-19) infected patients. This worsens the prognosis and may lead to death or life long morbidities. The laboratory finding of the disturbed haemostasias and the hyperinflammatory response are almost invariably present in COVID-19 patients. Multiple treatment modalities are utilized by the healthcare professionals to overcome the cytokine storm, oxidative stress, endothelial dysfunction, and coagulopathy in these patients...
April 1, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/36963882/systematic-review-and-meta-analysis-associations-of-vitamin-d-with-pulmonary-function-in-children-and-young-people-with-cystic-fibrosis
#34
JOURNAL ARTICLE
Raquel Revuelta Iniesta, Seren Cook, Gemma Oversby, Pelagia Koufaki, Marietta L Van der Linden, Dimitris Vlachopoulos, Craig A Williams, Don S Urquhart
BACKGROUND: Increasing evidence suggests that vitamin D is associated with pulmonary health, which may benefit children and young people diagnosed with Cystic Fibrosis (cypCF). Therefore, the aim of this systematic review was to evaluate primary research to establish associations between 25OHD and pulmonary health in cypCF. METHODS: Electronic databases were searched with keywords related to CF, vitamin D, children/young people and pulmonary function. Included studies were cypCF (aged ≤21 years) treated in a paediatric setting...
April 2023: Clinical Nutrition ESPEN
https://read.qxmd.com/read/36932016/safety-and-efficacy-of-a-new-supplementation-protocol-in-patients-with-cystic-fibrosis-and-vitamin-d-deficiency
#35
JOURNAL ARTICLE
Carmen Mangas-Sánchez, María Garriga-García, María Juliana Serrano-Nieto, Ruth Garcia-Romero, Marina Álvarez Beltrán, Elena Crehuá-Gaudiza, Saioa Vicente-Santamaría, Cecilia Martínez-Costa, Juan José Díaz-Martín, Carlos Bousoño-García, David González-Jiménez
OBJECTIVES: Based on the European and American Cystic Fibrosis (CF) consensus recommendations, an increase in vitamin D (VD) supplementation in patients with CF and insufficient or defficient levels was proposed. The objective of our study was to determine the safety and efficacy of this new protocol. MATERIAL AND METHODS: Multicentre nonrandomized uncontrolled experimental study. Patients with insufficient levels (<30 ng/mL) received increasing doses of VD (between 800 and 10 000 IU/day)...
March 15, 2023: Anales de pediatría
https://read.qxmd.com/read/36911094/bone-health-in-ambulatory-male-patients-with-chronic-obstructive-airway-disease-a-case-control-study-from-india
#36
JOURNAL ARTICLE
Mohammad Sadiq Jeeyavudeen, Samuel George Hansdek, Nihal Thomas, Thangakunam Balamugesh, Mahasampath Gowri, Thomas V Paul
OBJECTIVE: Chronic obstructive airway disease (COPD) is characterized by airflow limitation due to airway and/or alveolar abnormalities with significant extra-pulmonary manifestations. Bone health impairment is an extra-pulmonary complication of COPD which is less well studied in India. Moreover, it can contribute to significant morbidity and mortality. Hence, we aim to estimate the prevalence of osteoporosis and metabolic parameters of adverse bone health in patients with COPD. METHODS: In this case control study, male subjects aged 40-70 years with COPD attending the respiratory outpatient clinic in a tertiary care hospital were recruited over a period of 2 years and the control population were derived from the historical cohort who were apparently healthy with no obvious diseases...
March 2023: Aging medicine
https://read.qxmd.com/read/36904227/25-hydroxyvitamin-d-serum-concentration-and-covid-19-severity-and-outcome-a-retrospective-survey-in-a-romanian-hospital
#37
JOURNAL ARTICLE
Adriana Topan, Mihaela Lupse, Mihai Calin, Cristian Jianu, Daniel-Corneliu Leucuta, Violeta Briciu
Interest in the immunomodulatory function of vitamin D has grown since the COVID-19 pandemic started. Our study investigated the possible association between vitamin D deficiency and COVID-19 severity, intensive care needs, and mortality in patients hospitalized with COVID-19. A prospective cohort study was performed on 2342 COVID-19 hospitalized patients between April 2020 and May 2022 in a Romanian tertiary hospital for infectious diseases. A multivariate generalized linear model for binary data was fit with dependent variables: severe/critical form of COVID-19, intensive care need, and fatal outcome as a function of vitamin D deficiency, controlling for age, comorbidities, and vaccination status...
February 28, 2023: Nutrients
https://read.qxmd.com/read/36837547/oral-anticoagulation-in-patients-with-chronic-liver-disease
#38
REVIEW
Raluca S Costache, Andreea S Dragomirică, Bogdan E Gheorghe, Vasile D Balaban, Silviu M Stanciu, Mariana Jinga, Daniel O Costache
The administration of an anticoagulant in patients with liver disease (nonalcoholic steatohepatitis-NASH, nonalcoholic fatty liver disease-NAFLD, chronic hepatitis, or cirrhosis) who have an indication (atrial fibrillation, venous thrombosis, or pulmonary embolism) is challenging because there is an imbalance between thrombosis and bleeding. There is a need to focus our attention on preventing risk factors because diabetes, obesity, dyslipidemia, smoking, and sedentary behavior are risk factors for both NASH/NAFLD and AF, and these patients require anticoagulant treatment...
February 12, 2023: Medicina
https://read.qxmd.com/read/36761779/potential-targeted-therapy-based-on-deep-insight-into-the-relationship-between-the-pulmonary-microbiota-and-immune-regulation-in-lung-fibrosis
#39
REVIEW
Tao Zhang, Min Zhang, Liqing Yang, Lingyun Gao, Wei Sun
Pulmonary fibrosis is an irreversible disease, and its mechanism is unclear. The lung is a vital organ connecting the respiratory tract and the outside world. The changes in lung microbiota affect the progress of lung fibrosis. The latest research showed that lung microbiota differs in healthy people, including idiopathic pulmonary fibrosis (IPF) and acute exacerbation-idiopathic pulmonary fibrosis (AE-IPF). How to regulate the lung microbiota and whether the potential regulatory mechanism can become a necessary targeted treatment of IPF are unclear...
2023: Frontiers in Immunology
https://read.qxmd.com/read/36575358/a-novel-de-novo-frameshift-pathogenic-variant-in-the-fam111b-resulting-in-progressive-osseous-heteroplasia-phenotype
#40
JOURNAL ARTICLE
Anna Ryabets-Lienhard, Panadeekarn Panjawatanan, Kyle Vogt, Jianling Ji, Senta Georgia, Pisit Pitukcheewanont
INTRODUCTION: Progressive osseous heteroplasia (POH) is a rare, debilitating disorder characterized by heterotopic ossification in the skin and muscles, resulting in contractures of the joints and progressive loss of function. While 60-70% of the POH patients have paternally inherited, inactivating pathogenic variants in GNAS, the remaining 30-40% have no known etiology. FAM111B pathogenic variants, located on chromosome 11q12.1, cause POIKTMP (hereditary fibrosing poikiloderma with tendon contractures, myopathy, and pulmonary fibrosis), a very rare, autosomal-dominant disorder with high frequency of de novo missense pathogenic variants, which affects multiple tissues and organs, causing extensive fibrosis and muscle adiposis, though the exact mechanism is unknown...
December 27, 2022: Calcified Tissue International
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