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Pulmonary function and vitamin D

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https://www.readbyqxmd.com/read/27898998/nutritional-supplementation-for-hip-fracture-aftercare-in-older-people
#1
REVIEW
Alison Avenell, Toby O Smith, James P Curtain, Jenson Cs Mak, Phyo K Myint
BACKGROUND: Older people with hip fractures are often malnourished at the time of fracture, and subsequently have poor food intake. This is an update of a Cochrane review first published in 2000, and previously updated in 2010. OBJECTIVES: To review the effects (benefits and harms) of nutritional interventions in older people recovering from hip fracture. SEARCH METHODS: We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register, CENTRAL, MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, Embase, CAB Abstracts, CINAHL, trial registers and reference lists...
November 30, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27870560/effect-of-prenatal-versus-postnatal-vitamin-d-deficiency-on-pulmonary-structure-and-function-in-mice
#2
Ammar Saadoon, Namasivayam Ambalavanan, Kurt Zinn, Ambika P Ashraf, Mark MacEwen, Teodora Nicola, Michelle V Fanucchi, William T Harris
Epidemiologic studies have linked gestational vitamin D deficiency to respiratory diseases, although mechanisms have not been defined. We hypothesized that antenatal vitamin D deficiency would impair airway development and alveolarization in a mouse model. We studied the effect of antenatal vitamin D deficiency by inducing vitamin D deficiency in pregnant mice and then compared lung development and function in their offspring to littermate controls. Postnatal vitamin D deficiency and sufficiency models from each group were also studied...
November 21, 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27858878/association-between-pulmonary-fibrosis-and-osteoporosis-in-the-elderly-people-a-case-control-study
#3
Zhong Xie, Yanhong He, Yongqiang Sun, Zhanzhan Lin, Mingzhi Yang, Qian Liu, Sihai Liu
In this case-control study, we evaluated the association between osteoporosis and pulmonary fibrosis in the elderly. Participants were divided into a test group and a control group depending on bone mineral density and grid pattern changes of pulmonary fibrosis. We measured general conditions, related risk factors, serum biochemical index, grid pattern changes of double lungs, pulmonary function, arterial oxygen pressure (PO2), and bone mineral density of participates, and investigated the data through statistical analysis on SPSS 17...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27818797/serum-magnesium-and-vitamin-d-levels-as-indicators-of-asthma-severity
#4
Mohammed Nadeem Shaikh, Brahma Reddy Malapati, Ruchi Gokani, Bhavita Patel, Mitul Chatriwala
Background. Serum magnesium levels affect the concentration of circulating vitamin D in blood and subsequently it affects the immunity; thus it plays significant role in the pathogenesis of asthma. Asthma, in adults, is less studied and hypomagnesemia along with vitamin D deficiency and insufficiency is common in asthmatic individuals, which causes frequent asthma attacks, respiratory infections, severe exacerbations, and poor response to bronchodilators. Objective. To detect the magnitude of vitamin D insufficiency and deficiency and serum magnesium levels among asthmatic patients and to correlate them with the severity of asthma...
2016: Pulmonary Medicine
https://www.readbyqxmd.com/read/27795667/chronic-ethanol-exposure-effects-on-vitamin-d-levels-among-subjects-with-alcohol-use-disorder
#5
Olalekan Ogunsakin, Tete Hottor, Ashish Mehta, Maureen Lichtveld, Michael McCaskill
Vitamin D has been previously recognized to play important roles in human immune system and function. In the pulmonary system, vitamin D regulates the function of antimicrobial peptides, especially cathelicidin/LL-37. Human cathelicidin/LL-37 is a bactericidal, bacteriostatic, and antiviral endogenous peptide with protective immune functions. Chronic exposure to excessive alcohol has the potential to reduce levels of vitamin D (inactive vitamin D [25(OH)D3] and active vitamin D [1, 25(OH)2D3]) and leads to downregulation of cathelicidin/LL-37...
2016: Environmental Health Insights
https://www.readbyqxmd.com/read/27785354/the-frequency-distribution-of-vitamin-d-receptor-fok-i-gene-polymorphism-among-ugandan-pulmonary-tb-patients
#6
Ester L Acen, William Worodria, Peter Mulamba, Andrew Kambugu, Joseph Erume
Background:Mycobacterium tuberculosis (TB) is still a major problem globally and especially in Africa. Vitamin D deficiency has been linked to TB in the past and studies have found vitamin D deficiency to be common among Ugandan TB patients. The functional activity of vitamin D is dependent on the genotype of the vitamin D receptor (VDR) polymorphic genes. Recent findings have indicated that VDR polymorphisms may cause increased resistance or susceptibility to TB. The vitamin D ligand and its receptor play a pivotal role in innate immunity by eliciting antimicrobial activity, which is important in prevention of TB...
2016: F1000Research
https://www.readbyqxmd.com/read/27737326/effects-of-vitamin-d-supplementation-on-pulmonary-function-in-postmenopausal-women-following-an-aquatic-exercise-program
#7
Rodrigo Nolasco, Linda D F Moreira, Danilo S Bocalini, Fernanda C A O Fronza, Rosangela Villa Marin, Marise Lazaretti-Castro
Objective: This study sought to investigate the effects of vitamin D supplementation and aquatic exercise on pulmonary function in postmenopausal women. Materials and methods: This prospective and controlled study included 104 women (62 ± 6.5 years) divided into three groups: a control group lacking vitamin D and calcium supplementation which remained sedentary (CG; n = 17); a control group receiving vitamin D and calcium supplementation which remained sedentary (CDG, n = 33); and a group that completed aquatic exercises three times a week and received vitamin D and calcium supplementation (DTG, n = 54)...
October 10, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27699476/the-association-between-bone-mineral-density-and-airflow-limitation-in-a-cohort-of-fit-elderly-women
#8
Caterina Trevisan, A Vianello, N Veronese, S Carraro, S Pizzato, P Lucato, G Girotti, C Rinaldo, A Coin, E Manzato, G Sergi
PURPOSE: As studies examining the association between bone mineral density (BMD) and airflow limitation (AL) have produced conflicting results, the current one set out to analyze if and to what degree there are any correlations between these variables in a population of fit elderly women. METHODS: One hundred and twenty-one non-smoking, fit and healthy women (age ≥ 65 years) underwent anthropometric assessment, laboratory testing (serum 25-hydroxy vitamin D, parathormone, and cytokine levels), pulmonary function testing (PFT), and dual-energy X-ray absorptiometry to evaluate BMD values of the lumbar and femoral regions...
October 3, 2016: Lung
https://www.readbyqxmd.com/read/27622174/osteoporosis-associated-with-chronic-obstructive-pulmonary-disease
#9
REVIEW
Ryo Okazaki, Reiko Watanabe, Daisuke Inoue
Recent epidemiological studies have revealed that osteoporosis is closely associated with common chronic diseases including diabetes, hypertension, chronic kidney disorders, and chronic obstructive pulmonary disease (COPD). COPD is a chronic inflammatory airway disease but now well known to be associated with various systemic comorbidities including osteoporosis. Osteoporosis and osteoporotic fractures are extremely common in COPD patients, which have significant impacts on their quality of life (QOL), activities of daily life (ADL), respiratory function, and possibly their prognosis...
August 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27595605/vitamin-d-receptor-gene-associations-with-pulmonary-tuberculosis-in-a-tibetan-chinese-population
#10
Qunying Hu, Zhengshuai Chen, Guinian Liang, Fangping Mo, Hengxun Zhang, Shilin Xu, Yuhe Wang, Longli Kang, Tianbo Jin
BACKGROUND: The vitamin D receptor (VDR) mediates the immunological function of vitamin D3, which activates macrophages, and vitamin D deficiency has been linked to tuberculosis risk. Single nucleotide polymorphisms (SNPs) in VDR may influence the function of vitamin D and susceptibility to tuberculosis. METHODS: This study included 217 patients with pulmonary tuberculosis (PTB) and 383 healthy subjects in a Tibetan Chinese population living in and near Xi'an. Association analyses of SNPs in VDR were performed with the SPSS 17...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27489466/the-effect-of-vitamin-d-on-lower-respiratory-tract-infections-in-children
#11
Tuğba Şişmanlar, Ayşe Tana Aslan, Özlem Gülbahar, Seçil Özkan
AIM: Lower respiratory tract infections including mainly pneumonia represent an important public health problem leading to high mortality and mobidity rates in children aged below five years in developing countries including our country. Vitamin D deficiency has been associated with increased risk of rickets/osteomalacia, various cancers, autoimmune diseases, hyperproliferative skin diseases, cardiovascular system diseases and infectious diseases. Vitamin D has an important role in cellular and humoral immunity and pulmonary functions...
June 2016: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/27477800/low-grade-disease-activity-in-early-life-precedes-childhood-asthma-and-allergy
#12
Bo Lund Krogsgaard Chawes
Asthma and allergies are today the most common chronic diseases in children and the leading causes of school absences, chronic medication usage, emergency department visits and hospitalizations, which affect all members of the family and represent a significant societal and scientific challenge. These highly prevalent disorders are thought to originate from immune distortion in early childhood, but the etiology and heterogeneity of the disease mechanisms are not understood, which hampers preventive initiatives and makes treatment inadequate...
August 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27477034/the-relationship-between-serum-levels-of-vitamin-d-with-asthma-and-its-symptom-severity-a-case-control-study
#13
Rasoul Nasiri Kalmarzi, A Zamani, A Fathallahpour, E Ghaderi, Ramesh Rahehagh, W Kooti
BACKGROUND: Asthma is a heterogeneous disease characterised by chronic inflammatory airways, and is affected by several immunological factors. One of the most discussed and researched hypotheses is the relationship between vitamin D serum levels with asthma. This study aimed to investigate the relationship between vitamin D serum levels with asthma and pulmonary functions in children in Kurdistan province, Iran. MATERIALS AND METHODS: In this case-control study, 120 children ranging from 6 to 18 years were referred in summer for investigation...
July 28, 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27449998/effect-of-1-25-dihydroxyvitamin-d3-on-the-expression-of-mannose-receptor-dc-sign-and-autophagy-genes-in-pulmonary-tuberculosis
#14
K Afsal, P Selvaraj
1,25-dihydroxyvitamin D3 [1,25(OH)2D3] is a powerful immuno-modulator, which enhances expression of antimicrobial peptides and induces autophagy in monocytes/macrophages. Since 1,25(OH)2D3 increases the phagocytic potential of monocytes/macrophages, we have explored the effect of 1,25(OH)2D3 on the expression of receptors such as mannose receptor (CD206) and DC-SIGN (CD209) as well as autophagy genes such as ATG5 and Beclin-1 (BECN1) in monocytes/macrophages of healthy controls (HCs) and pulmonary tuberculosis (PTB) patients with and without cavitary disease...
July 2016: Tuberculosis
https://www.readbyqxmd.com/read/27424501/the-immunobiological-and-clinical-role-of-vitamin-d-in-obstructive-lung-diseases
#15
Paolo Solidoro, Michela Bellocchia, Fabrizio Facchini
Vitamin D is a fat-soluble vitamin, which is obtained by conversion of 7-dehydrocholesterol in the skin by UV ray and by diet. Its role on bone mineralization has been known for over two hundred years, while its non-skeletal effects have been acknowledged only in the last few years. The discovery of important vitamin D properties on the innate and adaptive immune system created a lot of interest in a potential role of vitamin D on diseases characterized by heightened inflammation and oxidative response, and impaired antimicrobial response, such as asthma and chronic obstructive pulmonary disease (COPD)...
June 2016: Minerva Medica
https://www.readbyqxmd.com/read/27308869/the-immunobiological-and-clinical-role-of-vitamin-d-in-obstructive-lung-diseases
#16
Paolo Solidoro, Michela Bellocchia, Fabrizio Facchini
Vitamin D is a fat-soluble vitamin, which is obtained by conversion of 7-dehydrocholesterol in the skin by UV ray and by diet. Its role on bone mineralization has been known for over two hundred years, while its non-skeletal effects have been acknowledged only in the last few years. The discovery of important vitamin D properties on the innate and adaptive immune system created a lot of interest in a potential role of vitamin D on diseases characterized by heightened inflammation and oxidative response, and impaired antimicrobial response, such as asthma and chronic obstructive pulmonary disease (COPD)...
June 15, 2016: Minerva Medica
https://www.readbyqxmd.com/read/27273785/vitamin-d-and-pulmonary-function-in-obese-asthmatic-children
#17
Laura A Lautenbacher, Sunit P Jariwala, Morri E Markowitz, Deepa Rastogi
OBJECTIVE: Asthma-related morbidity is higher among children with vitamin D deficiency and obesity, morbidities that frequently co-exist among minority children. However, the effect of co-existent obesity and vitamin D deficiency on pulmonary function is poorly understood. METHODS: We compared percent-predicted values of pulmonary function across vitamin D categories among 72 obese and 71 normal-weight Hispanic and African-American children with asthma recruited at an urban children's hospital...
December 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27143867/evidence-of-functional-declining-and-global-comorbidity-measured-at-baseline-proved-to-be-the-strongest-predictors-for-long-term-death-in-elderly-community-residents-aged-85-years-a-5-year-follow-up-evaluation-the-octabaix-study
#18
Francesc Formiga, Assumpta Ferrer, Gloria Padros, Abelardo Montero, Carme Gimenez-Argente, Xavier Corbella
OBJECTIVE: To investigate the predictive value of functional impairment, chronic conditions, and laboratory biomarkers of aging for predicting 5-year mortality in the elderly aged 85 years. METHODS: Predictive value for mortality of different geriatric assessments carried out during the OCTABAIX study was evaluated after 5 years of follow-up in 328 subjects aged 85 years. Measurements included assessment of functional status comorbidity, along with laboratory tests on vitamin D, cholesterol, CD4/CD8 ratio, hemoglobin, and serum thyrotropin...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27125745/function-and-change-with-aging-of-%C3%AE-klotho-in-the-kidney
#19
K Akasaka-Manya, H Manya, T Endo
The α-Klotho mouse is an animal model that prematurely shows phenotypes resembling human aging, such as osteoporosis, arteriosclerosis, pulmonary emphysema, and kidney damage. Interestingly, these abnormalities are triggered by a deficiency of a single protein, α-Klotho. The kidney is an organ that highly expresses α-Klotho, suggesting that α-Klotho is important for kidney function. Recent studies suggest that α-Klotho is associated with phosphate, vitamin D, and calcium homeostasis. The calcium imbalance in α-Klotho mice may induce calpain overactivation, leading to cell death and tissue destruction...
2016: Vitamins and Hormones
https://www.readbyqxmd.com/read/27121020/identification-of-vitamin-d-sensitive-pathways-during-lung-development
#20
Ling Chen, Richard Wilson, Ellen Bennett, Graeme R Zosky
BACKGROUND: We have previously shown that vitamin D deficiency has a detrimental impact on lung development. In this study, we aimed to identify the mechanisms linking vitamin D with lung development using a mouse model of dietary manipulation. METHODS: Female offspring were euthanized at different time-points; embryonic day (E)14.5, E17.5 or postnatal day (P)7. Lung tissue was collected for mass spectrometry-based proteomic analysis. Label-free quantitation was used to identify the differentially expressed proteins and ELISA confirmed the expression of selected proteins...
2016: Respiratory Research
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