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Pulmonary function and vitamin D

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https://www.readbyqxmd.com/read/28508087/the-vitamin-d-for-enhancing-the-immune-system-in-cystic-fibrosis-disc-trial-rationale-and-design-of-a-multi-center-double-blind-placebo-controlled-trial-of-high-dose-bolus-administration-of-vitamin-d3-during-acute-pulmonary-exacerbation-of-cystic-fibrosis
#1
Vin Tangpricha, Ellen M Smith, Jose Binongo, Suzanne E Judd, Thomas R Ziegler, Seth Walker, Rabindra Tirouvanziam, Susu M Zughaier, Moon Jeong Lee, Supavit Chesdachai, Wendy A Hermes, James F Chmiel, Amit Gaggar, Ruth E Grossmann, Patricia M Joseph, Jessica A Alvarez
Vitamin D deficiency is highly prevalent in children and adults with cystic fibrosis (CF). Recent studies have found an association between vitamin D status and risk of pulmonary exacerbations in children and adults with CF. The ongoing Vitamin D for enhancing the Immune System in Cystic fibrosis (DISC) study is a multi-center, double-blind, randomized, placebo-controlled trial that will test the hypothesis of whether high dose vitamin D given as a single oral bolus of 250,000 IU to adults with CF during a pulmonary exacerbation followed by a maintenance dose of vitamin D will improve time to next pulmonary exacerbation and re-hospitalization, improve survival and lung function compared to placebo and reduce the rates of pulmonary exacerbation,...
June 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/28495620/vitamin-c-to-decrease-the-effects-of-smoking-in-pregnancy-on-infant-lung-function-vcsip-rationale-design-and-methods-of-a-randomized-controlled-trial-of-vitamin-c-supplementation-in-pregnancy-for-the-primary-prevention-of-effects-of-in-utero-tobacco-smoke-exposure
#2
Cindy T McEvoy, Kristin F Milner, Ashley J Scherman, Diane G Schilling, Christina J Tiller, Brittany Vuylsteke, Lyndsey E Shorey-Kendrick, Eliot R Spindel, Robert Schuff, Julie Mitchell, Dawn Peters, Jill Metz, David Haas, Keith Jackson, Robert S Tepper, Cynthia D Morris
Despite strong anti-smoking efforts, at least 12% of American women cannot quit smoking when pregnant resulting in >450,000 smoke-exposed infants born yearly. Smoking during pregnancy is the largest preventable cause of childhood respiratory illness including wheezing and asthma. Recent studies have shown a protective effect of vitamin C supplementation on the lung function of offspring exposed to in utero smoke in a non-human primate model and an initial human trial. Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) is a randomized, double-blind, placebo-controlled trial to evaluate pulmonary function at 3months of age in infants delivered to pregnant smokers randomized to 500mg/day of vitamin C versus placebo during pregnancy...
May 8, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28422514/vitamin-c-prevents-offspring-dna-methylation-changes-associated-with-maternal-smoking-in-pregnancy
#3
Lyndsey E Shorey-Kendrick, Cindy T McEvoy, Betsy Ferguson, Julja Burchard, Byung S Park, Lina Gao, Brittany H Vuylsteke, Kristin F Milner, Cynthia D Morris, Eliot R Spindel
BACKGROUND: Infants whose mothers smoked during pregnancy demonstrate lifelong decreases in pulmonary function. DNA methylation changes associated with maternal smoking during pregnancy have been described in placenta and cord blood at delivery, in fetal lung, and in buccal epithelium and blood during childhood. We recently demonstrated in a randomized clinical trial (NCT00632476) that vitamin C supplementation to pregnant smokers can lessen the impact of maternal smoking on offspring pulmonary function and decrease the incidence of wheeze at one year of age...
April 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28377173/effect-of-alfacalcidol-on-the-pulmonary-function-of-adult-asthmatic-patients-a-randomized-trial
#4
Amani M Ali, Samah Selim, Maggie M Abbassi, Nirmeen A Sabry
BACKGROUND: Despite the use of alfacalcidol in the management of corticosteroid-induced osteoporosis, it has never been considered an adjunct treatment for asthma management. It can target vitamin D deficiency, a possible risk factor for asthma, and, hence, improve pulmonary function of patients with asthma. OBJECTIVE: To explore the effect of alfacalcidol administration on pulmonary function and study the pattern of vitamin D deficiency in adults with asthma in Egypt...
May 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28365177/high-dose-vitamin-d-after-lung-transplantation-a-randomized-trial
#5
Robin Vos, David Ruttens, Stijn E Verleden, Elly Vandermeulen, Hannelore Bellon, Anke Van Herck, Annelore Sacreas, Tobias Heigl, Veronique Schaevers, Dirk E Van Raemdonck, Eric K Verbeken, Arne P Neyrinck, Lieven J Dupont, Jonas Yserbyt, Bart M Vanaudenaerde, Geert M Verleden
BACKGROUND: Vitamin D may have innate immunomodulatory functions with potentially beneficial therapeutic effects in lung transplant recipients. METHODS: This was a single-center, double blind, randomized, placebo-controlled, prevention trial of once-monthly oral vitamin D (cholecalciferol; 100,000 IU, n = 44) vs placebo (n = 43) during 2 years in adult lung transplant recipients enrolled from October 2010 to August 2013. Primary outcome was prevalence of chronic lung allograft dysfunction (CLAD) 3 years after transplantation...
March 8, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28340855/no-mediating-effects-of-glycemic-control-and-inflammation-on-the-association-between-vitamin-d-and-lung-function-in-the-general-population
#6
Anne Kaul, Sven Gläser, Anke Hannemann, Beate Stubbe, Stefan B Felix, Matthias Nauck, Ralf Ewert, Nele Friedrich
BACKGROUND: Vitamin D deficiency is discussed to be associated with lung health. While former studies focused on subjects suffering from pulmonary diseases, we aimed to investigate the association of 25-hydroxy vitamin D [25(OH)D] with lung function in the general population and examined whether mediating effects of inflammation, glycemic control or renal function exist. METHODS: 1404 participants from the Study of Health in Pomerania with pulmonary function testing assessed by expiratory volume in 1 s (FEV1), forced vital capacity (FVC), total lung capacity and Krogh index were used...
April 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28320552/association-between-severe-vitamin-d-deficiency-lung-function-and-asthma-control
#7
Seda Beyhan-Sagmen, Ozgur Baykan, Baran Balcan, Berrin Ceyhan
INTRODUCTION: To examine the relationship between severe vitamin D deficiency, asthma control, and pulmonary function in Turkish adults with asthma. METHODS: One hundred six asthmatic patients underwent pulmonary function tests skin prick test, peripheral blood eosinophil counts, IgE, body mass index and vitamin D levels were determined. Patients were divided into 2 subgroups according to vitamin D levels (vitamin D level<10ng/ml and vitamin D level≥10 ng/ml)...
March 17, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28231689/are-children-with-asthma-in-south-korea-also-associated-with-vitamin-d-deficiency
#8
Yu-Ri Kim, Sung Chul Seo, Young Yoo, Ji Tae Choung
Recently, epidemiologic studies have shown that the lack of serum vitamin D levels may be associated with high asthma prevalence, but its effect is still controversial, depending on season, area, and food consumption. We aimed to examine the association of serum vitamin D levels with the prevalence of pediatric asthma in Korea. A total of 80 children (50 asthmatic children and 30 healthy controls) aged 6-14 years were participated in this study. Serum vitamin D levels were measured and compared between the two groups...
2017: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/28144749/amount-of-smoking-pulmonary-function-and-bone-mineral-density-in-middle-aged-korean-men-knhanes-2008-2011
#9
Ji Hyun Lee, A Ram Hong, Jung Hee Kim, Kyoung Min Kim, Bo Kyung Koo, Chan Soo Shin, Sang Wan Kim
Smoking induces bone loss; however, data on the relationship between smoking history and bone mineral density (BMD) are lacking. Age and pulmonary function can affect BMD. We investigated the relationships among pack-years (PYs) of smoking, pulmonary function, and BMD in middle-aged Korean men (50-64 years old). This cross-sectional study used data from the Korean National Health and Nutrition Examination Survey, 2008-2011. All participants underwent BMD measurements using dual energy X-ray absorptiometry and pulmonary function tests using standardized spirometry...
January 31, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28141562/association-of-serum-vitamin-d-levels-with-level-of-control-of-childhood-asthma
#10
T K Kavitha, Nandita Gupta, Sushil K Kabra, Rakesh Lodha
OBJECTIVE: To study the association between serum vitamin D levels and levels of asthma control in children aged 5-15 years. METHODS: Children with physician-diagnosed asthma who were under follow-up for at least 6 months were enrolled. Participants were categorized into three asthma control groups as per standard guidelines, and their serum 25-hydroxy vitamin D levels and pulmonary function tests were compared. Results: Out of 105 children with asthma enrolled in the study, 50 (47...
January 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/27999642/benefits-from-the-correction-of-vitamin-d-deficiency-in-patients-with-pulmonary-hypertension
#11
Ahmad Mirdamadi, Pouya Moshkdar
BACKGROUND: Vitamin D (Vit D) is linked to various conditions including musculoskeletal, metabolic and cardiopulmonary diseases. However, it is not clear whether correction of vit D deficiency exerts any beneficial effect in patients with pulmonary hypertension. METHODS: This study was a prospective uncontrolled longitudinal study. Patients with pulmonary hypertension and vit D deficiency were enrolled into this study. All patients in addition to standard treatment for pulmonary hypertension received cholecalciferol at a dose of 50,000 IU weekly plus calcicare (at a dose of 200 mg magnesium + 8 mg zinc + 400 IU vit D) daily for 3 months...
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/27898998/nutritional-supplementation-for-hip-fracture-aftercare-in-older-people
#12
REVIEW
Alison Avenell, Toby O Smith, James P Curtain, Jenson Cs Mak, Phyo K Myint
BACKGROUND: Older people with hip fractures are often malnourished at the time of fracture, and subsequently have poor food intake. This is an update of a Cochrane review first published in 2000, and previously updated in 2010. OBJECTIVES: To review the effects (benefits and harms) of nutritional interventions in older people recovering from hip fracture. SEARCH METHODS: We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register, CENTRAL, MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, Embase, CAB Abstracts, CINAHL, trial registers and reference lists...
November 30, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27870560/effect-of-prenatal-versus-postnatal-vitamin-d-deficiency-on-pulmonary-structure-and-function-in-mice
#13
Ammar Saadoon, Namasivayam Ambalavanan, Kurt Zinn, Ambika P Ashraf, Mark MacEwen, Teodora Nicola, Michelle V Fanucchi, William T Harris
Epidemiologic studies have linked gestational vitamin D deficiency to respiratory diseases, although mechanisms have not been defined. We hypothesized that antenatal vitamin D deficiency would impair airway development and alveolarization in a mouse model. We studied the effect of antenatal vitamin D deficiency by inducing it in pregnant mice and then compared lung development and function in their offspring to littermate controls. Postnatal vitamin D deficiency and sufficiency models from each group were also studied...
March 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27858878/association-between-pulmonary-fibrosis-and-osteoporosis-in-the-elderly-people-a-case-control-study
#14
Zhong Xie, Yanhong He, Yongqiang Sun, Zhanzhan Lin, Mingzhi Yang, Qian Liu, Sihai Liu
In this case-control study, we evaluated the association between osteoporosis and pulmonary fibrosis in the elderly. Participants were divided into a test group and a control group depending on bone mineral density and grid pattern changes of pulmonary fibrosis. We measured general conditions, related risk factors, serum biochemical index, grid pattern changes of double lungs, pulmonary function, arterial oxygen pressure (PO2), and bone mineral density of participates, and investigated the data through statistical analysis on SPSS 17...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27818797/serum-magnesium-and-vitamin-d-levels-as-indicators-of-asthma-severity
#15
Mohammed Nadeem Shaikh, Brahma Reddy Malapati, Ruchi Gokani, Bhavita Patel, Mitul Chatriwala
Background. Serum magnesium levels affect the concentration of circulating vitamin D in blood and subsequently it affects the immunity; thus it plays significant role in the pathogenesis of asthma. Asthma, in adults, is less studied and hypomagnesemia along with vitamin D deficiency and insufficiency is common in asthmatic individuals, which causes frequent asthma attacks, respiratory infections, severe exacerbations, and poor response to bronchodilators. Objective. To detect the magnitude of vitamin D insufficiency and deficiency and serum magnesium levels among asthmatic patients and to correlate them with the severity of asthma...
2016: Pulmonary Medicine
https://www.readbyqxmd.com/read/27795667/chronic-ethanol-exposure-effects-on-vitamin-d-levels-among-subjects-with-alcohol-use-disorder
#16
Olalekan Ogunsakin, Tete Hottor, Ashish Mehta, Maureen Lichtveld, Michael McCaskill
Vitamin D has been previously recognized to play important roles in human immune system and function. In the pulmonary system, vitamin D regulates the function of antimicrobial peptides, especially cathelicidin/LL-37. Human cathelicidin/LL-37 is a bactericidal, bacteriostatic, and antiviral endogenous peptide with protective immune functions. Chronic exposure to excessive alcohol has the potential to reduce levels of vitamin D (inactive vitamin D [25(OH)D3] and active vitamin D [1, 25(OH)2D3]) and leads to downregulation of cathelicidin/LL-37...
2016: Environmental Health Insights
https://www.readbyqxmd.com/read/27785354/the-frequency-distribution-of-vitamin-d-receptor-fok-i-gene-polymorphism-among-ugandan-pulmonary-tb-patients
#17
Ester L Acen, William Worodria, Peter Mulamba, Andrew Kambugu, Joseph Erume
Background:Mycobacterium tuberculosis (TB) is still a major problem globally and especially in Africa. Vitamin D deficiency has been linked to TB in the past and studies have found vitamin D deficiency to be common among Ugandan TB patients. The functional activity of vitamin D is dependent on the genotype of the vitamin D receptor (VDR) polymorphic genes. Recent findings have indicated that VDR polymorphisms may cause increased resistance or susceptibility to TB. The vitamin D ligand and its receptor play a pivotal role in innate immunity by eliciting antimicrobial activity, which is important in prevention of TB...
2016: F1000Research
https://www.readbyqxmd.com/read/27737326/effects-of-vitamin-d-supplementation-on-pulmonary-function-in-postmenopausal-women-following-an-aquatic-exercise-program
#18
Rodrigo Nolasco, Linda D F Moreira, Danilo S Bocalini, Fernanda C A O Fronza, Rosangela Villa Marin, Marise Lazaretti-Castro
Objective: This study sought to investigate the effects of vitamin D supplementation and aquatic exercise on pulmonary function in postmenopausal women. Materials and methods: This prospective and controlled study included 104 women (62 ± 6.5 years) divided into three groups: a control group lacking vitamin D and calcium supplementation which remained sedentary (CG; n = 17); a control group receiving vitamin D and calcium supplementation which remained sedentary (CDG, n = 33); and a group that completed aquatic exercises three times a week and received vitamin D and calcium supplementation (DTG, n = 54)...
January 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27699476/the-association-between-bone-mineral-density-and-airflow-limitation-in-a-cohort-of-fit-elderly-women
#19
Caterina Trevisan, A Vianello, N Veronese, S Carraro, S Pizzato, P Lucato, G Girotti, C Rinaldo, A Coin, E Manzato, G Sergi
PURPOSE: As studies examining the association between bone mineral density (BMD) and airflow limitation (AL) have produced conflicting results, the current one set out to analyze if and to what degree there are any correlations between these variables in a population of fit elderly women. METHODS: One hundred and twenty-one non-smoking, fit and healthy women (age ≥ 65 years) underwent anthropometric assessment, laboratory testing (serum 25-hydroxy vitamin D, parathormone, and cytokine levels), pulmonary function testing (PFT), and dual-energy X-ray absorptiometry to evaluate BMD values of the lumbar and femoral regions...
December 2016: Lung
https://www.readbyqxmd.com/read/27622174/osteoporosis-associated-with-chronic-obstructive-pulmonary-disease
#20
REVIEW
Ryo Okazaki, Reiko Watanabe, Daisuke Inoue
Recent epidemiological studies have revealed that osteoporosis is closely associated with common chronic diseases including diabetes, hypertension, chronic kidney disorders, and chronic obstructive pulmonary disease (COPD). COPD is a chronic inflammatory airway disease but now well known to be associated with various systemic comorbidities including osteoporosis. Osteoporosis and osteoporotic fractures are extremely common in COPD patients, which have significant impacts on their quality of life (QOL), activities of daily life (ADL), respiratory function, and possibly their prognosis...
August 2016: Journal of Bone Metabolism
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