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Polyacrylate acid

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https://www.readbyqxmd.com/read/28821965/increased-endocytosis-of-magnetic-nanoparticles-into-cancerous-urothelial-cells-versus-normal-urothelial-cells
#1
Jasna Lojk, Vladimir Boštjan Bregar, Klemen Strojan, Samo Hudoklin, Peter Veranič, Mojca Pavlin, Mateja Erdani Kreft
The blood-urine barrier is the tightest and most impermeable barrier in the body and as such represents a problem for intravesical drug delivery applications. Differentiation-dependent low endocytotic rate of urothelial cells has already been noted; however, the differences in endocytosis of normal and cancer urothelial cells have not been exploited yet. Here we analysed the endocytosis of rhodamine B isothiocyanate-labelled polyacrylic acid-coated cobalt ferrite nanoparticles (NPs) in biomimetic urothelial in vitro models, i...
August 18, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28789518/theranostic-iron-oxide-gold-ion-nanoprobes-for-mr-imaging-and-noninvasive-rf-hyperthermia
#2
Sajid Fazal, Bindhu Paul-Prasanth, Shantikumar V Nair, Deepthy Menon
This work focuses on the development of a nanoparticulate system that can be used for magnetic resonance (MR) imaging and E-field noninvasive radiofrequency (RF) hyperthermia. For this purpose, an amine-functional gold ion complex (GIC), [Au(III)(diethylenetriamine)Cl]Cl2, which generates heat upon RF exposure, was conjugated to carboxyl-functional poly(acrylic acid)-capped iron-oxide nanoparticles (IO-PAA NPs) to form IO-GIC NPs of size ∼100 nm. The multimodal superparamagnetic IO-GIC NPs produced T2-contrast on MR imaging and unlike IO-PAA NPs generated heat on RF exposure...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28782022/high-thermal-conductivity-in-electrostatically-engineered-amorphous-polymers
#3
Apoorv Shanker, Chen Li, Gun-Ho Kim, David Gidley, Kevin P Pipe, Jinsang Kim
High thermal conductivity is critical for many applications of polymers (for example, packaging of light-emitting diodes), in which heat must be dissipated efficiently to maintain the functionality and reliability of a system. Whereas uniaxially extended chain morphology has been shown to significantly enhance thermal conductivity in individual polymer chains and fibers, bulk polymers with coiled and entangled chains have low thermal conductivities (0.1 to 0.4 W m(-1) K(-1)). We demonstrate that systematic ionization of a weak anionic polyelectrolyte, polyacrylic acid (PAA), resulting in extended and stiffened polymer chains with superior packing, can significantly enhance its thermal conductivity...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28773232/thermal-performance-study-of-composite-phase-change-material-with-polyacrylicand-conformal-coating
#4
Shin Yiing Kee, Yamuna Munusamy, Kok Seng Ong, Hendrik Simon Cornelis Metselaar, Swee Yong Chee, Koon Chun Lai
The composite PCM was prepared by blending polymethyl methacrylate (PMMA) and myristic acid (MA) in different weight percentages. The MA and PMMA were selected as PCM and supporting material, respectively. As liquid MA may leak out during the phase transition, this study proposes the use of two coatings, namely a polyacrylic coating and a conformal coating to overcome the leakage problem. Both coatings were studied in terms of the leakage test, chemical compatibility, thermal stability, morphology, and reliability...
July 28, 2017: Materials
https://www.readbyqxmd.com/read/28772731/effects-of-electrospun-carbon-nanofibers-interlayers-on-high-performance-lithium-sulfur-batteries
#5
Tianji Gao, TrungHieu Le, Ying Yang, Zhihao Yu, Zhenghong Huang, Feiyu Kang
Two different interlayers were introduced in lithium-sulfur batteries to improve the cycling stability with sulfur loading as high as 80% of total mass of cathode. Melamine was recommended as a nitrogen-rich (N-rich) amine component to synthesize a modified polyacrylic acid (MPAA). The electrospun MPAA was carbonized into N-rich carbon nanofibers, which were used as cathode interlayers, while carbon nanofibers from PAA without melamine was used as an anode interlayer. At the rate of 0.1 C, the initial discharge capacity with two interlayers was 983 mAh g(-1), and faded down to 651 mAh g(-1) after 100 cycles with the coulombic efficiency of 95...
March 31, 2017: Materials
https://www.readbyqxmd.com/read/28772386/influence-of-porous-spherical-shaped-hydroxyapatite-on-mechanical-strength-and-bioactive-function-of-conventional-glass-ionomer-cement
#6
Szu-Yu Chiu, Yukari Shinonaga, Yoko Abe, Kyoko Harada, Kenji Arita
Glass-ionomer-cement (GIC) is helpful in Minimal Intervention Dentistry because it releases fluoride ions and is highly biocompatible. The aim of this study is to investigate the mechanisms by which hydroxyapatite (HAp) improves the mechanical strength and bioactive functioning of GIC when these materials are combined to make apatite ionomer cement (AIC). A conventional GIC powder was mixed with porous, spherical-HAp particles (HApS), crystalline HAp (HAp200) or one of two types of cellulose. The micro-compressive strengths of the additive particles were measured, and various specimens were evaluated with regard to their compressive strengths (CS), fluoride release concentrations (fluoride electrode) and multi-element release concentrations...
January 3, 2017: Materials
https://www.readbyqxmd.com/read/28756320/surface-tailoring-of-polyacrylate-grafted-graphene-oxide-for-controlled-interactions-at-the-biointerface
#7
Giuseppe Consiglio, Patrizia Di Pietro, Luisa D'Urso, Giuseppe Forte, Giuseppe Grasso, Carmelo Sgarlata, Damien Cossement, Rony Snyders, Cristina Satriano
The actual surface termination and lateral size of a nanomaterial is crucial in its interaction with biomolecules at the aqueous interface. Graphene oxide (GO) nanosheets have been demonstrated as promising nanoplatform for both diagnostic and therapeutic applications. To this respect, 'smart' GO nanocarriers have been obtained by the surface functionalisation with polymers sensitive, e.g., to pH, as the polyacrylate (PAA) case. In this work, hybrid GO/PAA samples prepared respectively at low (GOPAAthin) or high (GOPAAthick) monomer grafting ratio, were scrutinised both theoretically, by molecular dynamic calculations, and experimentally by a multitechnique approach, including spectroscopic (UV-visible, fluorescence, Raman, Attenuated-total reflectance-Fourier transformed infrared and X-ray photoelectron spectroscopies), spectrometric (time-of-flight secondary ion and electrospray ionisation mass spectrometries) and microscopic (atomic force and confocal microscopies) methods...
July 21, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28729506/highly-elastic-binders-integrating-polyrotaxanes-for-silicon-microparticle-anodes-in-lithium-ion-batteries
#8
Sunghun Choi, Tae-Woo Kwon, Ali Coskun, Jang Wook Choi
Lithium-ion batteries with ever-increasing energy densities are needed for batteries for advanced devices and all-electric vehicles. Silicon has been highlighted as a promising anode material because of its superior specific capacity. During repeated charge-discharge cycles, silicon undergoes huge volume changes. This limits cycle life via particle pulverization and an unstable electrode-electrolyte interface, especially when the particle sizes are in the micrometer range. We show that the incorporation of 5 weight % polyrotaxane to conventional polyacrylic acid binder imparts extraordinary elasticity to the polymer network originating from the ring sliding motion of polyrotaxane...
July 21, 2017: Science
https://www.readbyqxmd.com/read/28722154/application-of-headspace-solid-phase-microextraction-followed-by-gas-chromatography-coupled-with-mass-spectrometry-spme-gc-ms-to-determine-esters-of-carboxylic-acids-and-other-volatile-compounds-in-d-maculatus-and-d-ater-lipids
#9
Magdalena Cerkowniak, Mieczysława I Boguś, Emilia Włóka, Piotr Stepnowski, Marek Gołębiowski
A constant problem in veterinary medicine, human healthcare, agriculture, forestry or horticulture is the large number of pests, and the lack of effective methods to combat them which cause no harm to the rest of the environment. It is recommended and desired to reduce the use of chemicals and increase the use of agents based on the knowledge acquired in the field of biology, chemistry, and agrochemicals. To learn the defense mechanisms of insects we should consider not only the site of their physiological ability to protect against external factors (cuticle), but also check the possibility of chemical protection, formed by all compounds on the surface and in the body of insects...
July 19, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28717995/ovomucin-nanoparticles-promising-carriers-for-mucosal-delivery-of-drugs-and-bioactive-compounds
#10
Ali Akbari, Jianping Wu
Ovomucin, with a similar structure to mucin and gelation ability at room temperature, is a potential mucosal carrier. To evaluate this potential, the mucoadhesive property of ovomucin was studied by the tensile strength and rheology methods, and compared with three known mucoadhesive polymers, chitosan, polyacrylic acid (PAA), and alginate. Ovomucin particles were basically spherical in shape with an average size of ~572, 235 and 54 nm prepared at pH 5, 6.5, and 9, respectively. The absolute value of the zeta potential increased from ~ -51 mV at pH 5 to ~ -59 and -91 mV at pH 6...
August 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28699536/supramolecular-self-assembled-nanogels-a-new-platform-for-anticancer-drug-delivery
#11
Jaleh Varshosaz, Somayeh Taymouri, Erfaneh Ghassami
Polymer micellar nanogels are a group of core-shell polymeric micelles with swelling properties in aqueous media. Nanogel systems have proven their potential in controlled, sustained and targetable drug delivery area with no immunological responses. This review includes a comprehensive wide range of self-assembly of polymeric nanogels as delivery systems for anticancer drugs. Nanogels are nanoparticulate drug delivery systems which are specially designed for enhanced target oriented and cellular uptake of drugs with emphasis on chemotherapeutic agents studied in this review...
July 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28687387/hybrid-hydrogels-with-high-strength-and-biocompatibility-for-bone-regeneration
#12
Yongjiang Zheng, Keqing Huang, Xinru You, Bingxue Huang, Jun Wu, Zhipeng Gu
The development of hydrogels for bone regeneration has highlighted the challenge that load-bearing hydrogels need to be biocompatible while achieving high strength. Several approaches have been reported to improve the toughness of hydrogels, but achieving high toughness and biocompatibility simultaneously remains a challenge. Here we report a polyacrylic acid/alginate/demineralized bone matrix (PAA/Alg/DBM) hybrid double network hydrogel, which was synthesized by a two-step sequential polymerization with embedded DBM, possessing both high strength and biocompatibility...
July 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28684364/polyarginine-nanocapsules-a-versatile-nanocarrier-with-potential-in-transmucosal-drug-delivery
#13
Ana Gonzalez-Paredes, Dolores Torres, María José Alonso
The objective of this work was to investigate the potential utility of nanocapsules composed of an oily core decorated with a single polyarginine (PARG), or double PARG/polyacrylic acid (PAA) layer as oral peptide delivery carrier. A step-by-step formulation optimization process was designed, which involved the study of the influence of the surfactants, oils and polymer shells (PARG of different molecular weight and PAA) on the nanocapsules physicochemical properties, peptide loading efficiency, stability in simulated intestinal fluids (SIF) and capacity to enhance the permeability of the intestinal epithelium...
July 3, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28670098/a-multifunctional-nanocrystalline-caf2-tm-yb-msio2-system-for-dual-triggered-and-optically-monitored-doxorubicin-delivery
#14
Yangyang Li, Yurong Zhou, Tongxu Gu, Gang Wang, Zhaohui Ren, Wenjian Weng, Xiang Li, Gaorong Han, Chuanbin Mao
Daunting challenges in investigating the controlled release of drugs in complicated intracellular microenvironments demand the development of stimuli-responsive drug delivery systems. Here, a nanoparticle system, CaF2:Tm,Yb@mSiO2, made of a mesoporous silica (mSiO2) nanosphere with CaF2:Tm,Yb upconversion nanoparticles (UCNPs) is developed, filling its mesopores and with its surface-modified with polyacrylic acid for binding the anticancer drug molecules (doxorubicin, DOX). The unique design of CaF2:Tm,Yb@mSiO2 enables us to trigger the drug release by two mechanisms...
December 2016: Particle & Particle Systems Characterization: Measurement and Description of Particle Properties and Behavior in Powders and Other Disperse Systems
https://www.readbyqxmd.com/read/28657546/sensitive-detection-of-dopamine-via-leucodopaminechrome-on-polyacrylic-acid-coated-ceria-nanorods
#15
Weiqin Sheng, Liang Zheng, Yan Liu, Xueqin Zhao, Jian Weng, Yang Zhang
The major hurdle in detection of dopamine (DA) by electro-analysis is the presence of physiological interferents with a similar oxidation potential of DA. The conventional method is to enlarge the difference of their oxidation potentials. Here, we report an unconventional method to detect DA via leucodopaminechrome on CeO2 nanorods. Leucodopaminechrome is produced from the cyclization of dopamine-quinone, a product of two-electron oxidation of DA. Thus, its concentration is proportional to the DA concentration...
June 28, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28654748/preparation-of-poly-styrene-b-poly-acrylic-acid-coupled-carbon-dots-and-their-applications
#16
Moon-Jin Cho, Soo-Young Park
Carbon dots (CDs) are covalently coupled to the poly(acrylic acid) (PAA) block of polystyrene-b-poly(acrylic acid) (PS-b-PAA). The produced amphiphilic PS-b-PAA-CD shows excellent solubility and micellar formation in selective solvents. Transmission electron microscopy study shows that the micelle of PS-b-PAA-CD in water (a PAA-selective solvent) has a strawberry-like shape with the CDs as patches on the PAA corona surface although that in toluene (a PS-selective solvent) has a reversed shape with the CDs in the core...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28637416/mixed-micelles-as-nano-polymer-therapeutics-of-docetaxel-increased-in-vitro-cytotoxicity-and-decreased-in-vivo-toxicity
#17
Arehalli S Manjappa, Popat S Kumbhar, Prajakta S Khopade, Ajit B Patil, John I Disouza
Docetaxel (DTX) has been used to treat several types of cancers, but it has provided pharmaceutical challenges due to its poor water solubility and toxicities associated with the co-solvents (tween-80 and ethanol). Nanopolymer therapeutics can be engineered to deliver anticancer agent specifically to cancer cells, thereby leaving normal healthy cells unaffected by toxic drugs such as DTX. The objective of the present study was to synthesize the polyacrylic acid (PAA)-DTX conjugate (PAADC) and preparation of nanopolymer therapeutics such as PAADC/DSPE-mPEG2000 mixed micelles (PAADC-DP MMs)...
June 21, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28618381/magnetic-recyclable-bismuth-oxyiodide-polyacrylic-anion-exchange-resin-composites-with-enhanced-photocatalytic-activity-under-visible-light
#18
Jingjing Zheng, Zhengbo Jiao
A series of magnetic recyclable bismuth oxyiodide (BiOI)/polyacrylic anion exchange resin (PAER) composites with visible light responses have been synthesized for the first time through a facile and low-cost method at normal temperature. The photocatalytic performances of BiOI/PAER composites were evaluated by photodegrading 1-amino-8-naphthol-3,6-disulfonic acid under visible light. It was found that 1-amino-8-naphthol-3,6-disulfonic acid (H-acid) removal rate reached to 90.1% (BiOI/PAER-2), which was higher than the pure BiOI (50...
May 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28597656/enhancing-mechanical-and-thermal-properties-of-epoxy-nanocomposites-via-alignment-of-magnetized-sic-whiskers
#19
James Townsend, Ruslan Burtovyy, Pavel Aprelev, Konstantin G Kornev, Igor Luzinov
This research is focused on the fabrication and properties of epoxy nanocomposites containing magnetized SiC whiskers (MSiCWs). To this end, we report an original strategy for fabrication of magnetically active SiCWs by decorating the whiskers with magnetic (iron oxide) nanoparticles via polymer-polymer (poly(acrylic acid)/poly(2-vinyl pyridine)) complexation. The obtained whiskers demonstrated a substantial magnetic response in the polymerizing epoxy resin, with application of only a 20 mT (200 G) magnetic field...
July 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28551427/amorphous-solid-dispersion-of-meloxicam-enhanced-oral-absorption-in-rats-with-impaired-gastric-motility
#20
Hiroki Suzuki, Keisuke Yakushiji, Saori Matsunaga, Yukinori Yamauchi, Yoshiki Seto, Hideyuki Sato, Satomi Onoue
Meloxicam (MEL) shows a slow onset of action in severe pain patients due to delayed gastric motility. This study aimed to develop an amorphous solid dispersion (ASD) of MEL to achieve rapid oral absorption in severe pain patients. ASD formulations of MEL with hydroxypropylmethylcellulose (ASD-MEL/HPMC) and polyacrylates and polymethacrylates (ASD-MEL/EUD) were prepared and physicochemically characterized. Oral absorption behavior of MEL samples was also clarified in both normal and propantheline (PPT)-pretreated rats with impaired gastric motility...
May 24, 2017: Journal of Pharmaceutical Sciences
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