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https://www.readbyqxmd.com/read/29166635/the-protean-neuropsychiatric-and-vestibuloauditory-manifestations-of-neurosarcoidosis
#1
Jacqueline J Greene, Ilka C Naumann, Janet M Poulik, Kevin T Nella, Lindsay Weberling, Jeffrey P Harris, Akihiro J Matsuoka
BACKGROUND: A rare subset of sarcoidosis, neurosarcoidosis, is reported to occur in 5-7% of sarcoid patients and can manifest in a variety of ways. The most common are facial paralysis and optic neuritis, less commonly causing cochleovestibulopathy, blindness, anosmia, and other cranial nerve (CN) palsies. The sensory deficit may be severe and psychiatric symptoms may result from the effects of the disease or steroid treatment. Although MRI-compatible cochlear implants are now available, concerns about the feasibility of recoverable hearing with cochlear implantation in these patients as well as the practical difficulty of disease monitoring due to implant artifact must be considered...
November 23, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/29166551/evaluation-of-markers-out-of-the-steroid-profile-for-the-screening-of-testosterone-misuse-part-ii-intramuscular-administration
#2
Aristotelis Kotronoulas, Àlex Gomez-Gómez, Andreu Fabregat, Jordi Segura, Sheng Yang, Yanyi Xing, Wu Moutian, Josep Marcos, Jesús Joglar, Rosa Ventura, Oscar J Pozo
In the fight against doping, the introduction of alternative markers to the steroid profile can be considered as an effective approach to improve the screening capabilities for the detection of testosterone (T) misuse. The aim of this study was to evaluate the potential of several T metabolites (cysteinyl conjugated and glucuronoconjugated resistant to enzymatic hydrolysis) to detect both the transdermal and the intramuscular administration of T. In a first part of the study, we studied the potential of these metabolites for the detection of T transdermal administration...
November 22, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29166278/interactions-between-plant-derived-oestrogenic-substances-and-the-mycoestrogen-zearalenone-in-a-bioassay-with-mcf-7-cells
#3
Sabine Hessenberger, K Botzi, C Degrassi, P Kovalsky, C Schwab, D Schatzmayr, G Schatzmayr, J Fink-Gremmels
Human and animal diets may contain several non-steroidal oestrogenic compounds which originate either from plants (phytoestrogens) or from fungi that infect plants (mycoestrogens such as zearalenone (ZEN)). Phytoestrogens may compete with ZEN in binding to the oestrogen receptor β and thereby may counteract the oestrogenic activity of ZEN. Using a modified version of the E-screen assay, plant-derived oestrogenic substances were tested for their proliferative or anti-proliferative effect on oestrogen-dependent MCF-7 cells...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29165715/virus-induced-silencing-of-key-genes-leads-to-differential-impact-on-withanolide-biosynthesis-in-medicinal-plant-withania-somnifera
#4
Aditya Vikram Agarwal, Deeksha Singh, Yogeshwar Vikram Dhar, Rahul Michael, Parul Gupta, Deepak Chandra, Prabodh Kumar Trivedi
Withanolides are a collection of naturally occurring, pharmacologically active, secondary metabolites synthesised in medicinally important plant, Withania somnifera. These bioactive molecules are C28-steroidal lactone triterpenoids and their synthesis is proposed to take place via the mevalonate (MVA) and 2-C-methyl-D-erythritol-4-phosphate (MEP) pathways through the sterol pathway using 24-methylene cholesterol as substrate flux. Although the phytochemical profiles as well as pharmaceutical activities of Withania extracts have been well studied, limited genomic information and difficult genetic transformation have been major bottleneck towards understanding the participation of specific genes in withanolide biosynthesis...
November 20, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29165666/differences-in-outcomes-over-time-with-exclusive-enteral-nutrition-compared-to-steroids-in-children-with-mild-to-moderate-crohn-s-disease-results-from-the-growth-cd-study
#5
Noa Cohen-Dolev, Malgorata Sladek, Seamus Hussey, Dan Turner, Gabor Veres, Sibylle Koletzko, Javier Martin de Carpi, Annamaria Staiano, Ron Shaoul, Paolo Lionetti, Jorge Amil Dias, Anders Paerregaard, Federica Nuti, Tamar Pfeffer Gik, Tomer Ziv-Baran, Sivan Ben Avraham Shulman, Chen Sarbagili Shabat, Rotem Sigall Boneh, Richard K Russell, Arie Levine
Background: Exclusive enteral nutrition (EEN) and corticosteroids (CS) both induce similar rates of remission in mild to moderate pediatric Crohn's disease (CD), but differ with regard to mucosal healing. Our goal was to evaluate if EEN at diagnosis was superior to CS for improving long term outcomes. Methods: We prospectively followed newly diagnosed children <17 years with mild to moderate disease at baseline for two years in the GROWTH CD study. Patients were evaluated at baseline and at 8, 12, 78, and 104 weeks...
November 18, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29165577/quantitative-mri-brain-in-congenital-adrenal-hyperplasia-in-vivo-assessment-of-the-cognitive-and-structural-impact-of-steroid-hormones
#6
Emma A Webb, Lucy Elliott, Dominic Carlin, Martin Wilson, Kirsty Hall, Jennifer Netherton, Julie Reed, Tim G Barrett, Vijay Salwani, Jon D Clayden, Wiebke Arlt, Nils Krone, Andrew C Peet, Amanda G Wood
Context: Brain white matter hyper-intensities are seen on routine clinical imaging in 46% of adults with congenital adrenal hyperplasia (CAH). The extent and functional relevance of these abnormalities have not been studied using quantitative MRI analysis. Objective: To examine white matter microstructure, neural volumes and CNS metabolites in CAH due to 21-hydroxylase deficiency (21OHD) and to determine whether identified abnormalities are associated with cognition, glucocorticoid and androgen exposure...
November 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29165006/effect-of-non-steroidal-anti-inflammatory-drugs-on-postoperative-respiratory-and-heart-rate-in-cats-subjected-to-ovariohysterectomy
#7
Odd V Höglund, Barbara Dyall, Victoria Gräsman, Anna Edner, Ulf Olsson, Katja Höglund
Objectives The use of physiological parameters such as respiratory rate and heart rate to assess pain has long been discussed. The aim of the study was to compare postoperative respiratory rate and heart rate in cats subjected to flank ovariohysterectomy treated with a preoperative non-steroidal anti-inflammatory drug (NSAID) or no NSAID, and determine whether these parameters are suitable for postoperative pain assessment in cats. We hypothesised that cats without an NSAID would experience more postoperative pain, which may increase heart rate and respiratory rate...
November 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29164955/micellar-solubilization-of-poorly-water-soluble-drugs-effect-of-surfactant-and-solubilizate-molecular-structure
#8
Zahari Vinarov, V Katev, D Radeva, S Tcholakova, N D Denkov
OBJECTIVE: The current study aims to clarify the role of surfactant and drug molecular structures on drug solubility in micellar surfactant solutions. SIGNIFICANCE: (1) Rationale for surfactant selection is provided; (2) The large data set can be used for validation of the drug solubility parameters used in oral absorption models. METHODS: Equilibrium solubility of 2 hydrophobic drugs and one model hydrophobic steroid in micellar solutions of 19 surfactants was measured by HPLC...
November 22, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29164377/systemic-and-local-effects-of-vaginal-dehydroepiandrosterone-dhea-ncctg-n10c1-alliance
#9
Debra L Barton, Lynne T Shuster, Travis Dockter, Pamela J Atherton, Jacqueline Thielen, Stephen N Birrell, Richa Sood, Patricia Griffin, Shelby A Terstriep, Bassam Mattar, Jacqueline M Lafky, Charles L Loprinzi
BACKGROUND: Dehydroepiandrosterone (DHEA) is helpful for treating vaginal symptoms. This secondary analysis evaluated the impact of vaginal DHEA on hormone concentrations, bone turnover, and vaginal cytology in women with a cancer history. METHODS: Postmenopausal women, diagnosed with breast or gynecologic cancer, were eligible if they reported at least moderate vaginal symptoms. Participants could be on tamoxifen or aromatase inhibitors (AIs). Women were randomized to 3...
November 21, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29164214/withapubesides-a-d-natural-inducible-nitric-oxide-synthase-inos-inhibitors-from-physalis-pubescens
#10
Gui-Yang Xia, Tie Yao, Bing-Yang Zhang, Yang Li, Ning Kang, Shi-Jie Cao, Li-Qin Ding, Li-Xia Chen, Feng Qiu
Four new steroid glycosides, withapubesides A-D (1-4), were isolated from the stems of Physalis pubescens L. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1 and 2 were deduced by single-crystal X-ray diffraction and ECD data analysis, respectively. Compound 3 has shown significant inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages with an IC50 value of 12.8 μM and moderate cytostatic activity against human carcinoma cells (786-O, C4-2B, 22Rvl, A375 and A375S2) with IC50 values in the range of 3...
November 22, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29164025/a-clinical-practice-guideline-for-the-management-of-patients-with-acute-spinal-cord-injury-recommendations-on-the-use-of-methylprednisolone-sodium-succinate
#11
Michael G Fehlings, Jefferson R Wilson, Lindsay A Tetreault, Bizhan Aarabi, Paul Anderson, Paul M Arnold, Darrel S Brodke, Anthony S Burns, Kazuhiro Chiba, Joseph R Dettori, Julio C Furlan, Gregory Hawryluk, Langston T Holly, Susan Howley, Tara Jeji, Sukhvinder Kalsi-Ryan, Mark Kotter, Shekar Kurpad, Brian K Kwon, Ralph J Marino, Allan R Martin, Eric Massicotte, Geno Merli, James W Middleton, Hiroaki Nakashima, Narihito Nagoshi, Katherine Palmieri, Andrea C Skelly, Anoushka Singh, Eve C Tsai, Alexander Vaccaro, Albert Yee, James S Harrop
Introduction: The objective of this guideline is to outline the appropriate use of methylprednisolone sodium succinate (MPSS) in patients with acute spinal cord injury (SCI). Methods: A systematic review of the literature was conducted to address key questions related to the use of MPSS in acute SCI. A multidisciplinary Guideline Development Group used this information, in combination with their clinical expertise, to develop recommendations for the use of MPSS...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29163463/selective-glucocorticoid-receptor-properties-of-gsk866-analogs-with-cysteine-reactive-warheads
#12
Chandra S Chirumamilla, Ajay Palagani, Balu Kamaraj, Ken Declerck, Marinus W C Verbeek, Ryabtsova Oksana, Karolien De Bosscher, Nadia Bougarne, Bart Ruttens, Kris Gevaert, René Houtman, Winnok H De Vos, Jurgen Joossens, Pieter Van Der Veken, Koen Augustyns, Xaveer Van Ostade, Annemie Bogaerts, Hans De Winter, Wim Vanden Berghe
Synthetic glucocorticoids (GC) are the mainstay therapy for treatment of acute and chronic inflammatory disorders. Due to the high adverse effects associated with long-term use, GC pharmacology has focused since the nineties on more selective GC ligand-binding strategies, classified as selective glucocorticoid receptor (GR) agonists (SEGRAs) or selective glucocorticoid receptor modulators (SEGRMs). In the current study, GSK866 analogs with electrophilic covalent-binding warheads were developed with potential SEGRA properties to improve their clinical safety profile for long-lasting topical skin disease applications...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163355/regulation-of-gonadotropin-releasing-hormone-1-5-signaling-genes-by-estradiol-is-age-dependent
#13
Bradly M Bauman, Weiling Yin, Andrea C Gore, T John Wu
Gonadotropin-releasing hormone (GnRH) is a key regulatory molecule of the hypothalamus-pituitary (PIT)-gonadal (HPG) axis that ultimately leads to the downstream release of estradiol (E2) and progesterone (P). These gonadal steroids feed back to the hypothalamus and PIT to regulate reproductive function and behavior. While GnRH is thought to be the master regulator of reproduction, its metabolic product GnRH-(1-5) is also biologically active. Thimet oligopeptidase 1 (also known as EP24.15) cleaves GnRH to form GnRH-(1-5)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29163153/ketogal-a-derivative-ketorolac-molecule-with-minor-ulcerogenic-and-renal-toxicity
#14
Roberto Russo, Carmen De Caro, Bice Avallone, Salvatore Magliocca, Maria Nieddu, Gianpiero Boatto, Roberta Troiano, Rosario Cuomo, Carla Cirillo, Carmen Avagliano, Claudia Cristiano, Giovanna La Rana, Giovanni Sarnelli, Antonio Calignano, Maria G Rimoli
Ketorolac is a powerful non-steroidal anti-inflammatory drug (NSAID), with a great analgesic activity, present on the Italian market since 1991. Despite the excellent therapeutic activity, the chronic use of ketorolac has long been limited owing to the high incidence of gastrointestinal and kidney side events. In our previous study, we demonstrated that ketorolac-galactose conjugate (ketogal), synthesized and tested in a single-dose study, was able to reduce ulcerogenicity, while preserving the high pharmacological efficacy of its parent drug...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29162660/survival-in-very-preterm-infants-an-international-comparison-of-10-national-neonatal-networks
#15
Kjell Helenius, Gunnar Sjörs, Prakesh S Shah, Neena Modi, Brian Reichman, Naho Morisaki, Satoshi Kusuda, Kei Lui, Brian A Darlow, Dirk Bassler, Stellan Håkansson, Mark Adams, Maximo Vento, Franca Rusconi, Tetsuya Isayama, Shoo K Lee, Liisa Lehtonen
OBJECTIVES: To compare survival rates and age at death among very preterm infants in 10 national and regional neonatal networks. METHODS: A cohort study of very preterm infants, born between 24 and 29 weeks' gestation and weighing <1500 g, admitted to participating neonatal units between 2007 and 2013 in the International Network for Evaluating Outcomes of Neonates. Survival was compared by using standardized ratios (SRs) comparing survival in each network to the survival estimate of the whole population...
November 21, 2017: Pediatrics
https://www.readbyqxmd.com/read/29162649/effects-of-sympathectomy-on-ovarian-follicular-development-and-steroid-secretion
#16
Maritza Paola Garrido, Daniela Fernandois, Mauricio Venegas, Alfonso Paredes
Recently, the influence of adrenergic activity over ovarian function, and thus fertility, has begun to gain importance. Previous studies have shown that adrenergic activity through norepinephrine (NE) participates in the control of follicular development and steroidal secretion from the ovary, among other functions. To examine this phenomenon, the denervation of the gonad has been widely used to observe changes in the ovary's performance. Nevertheless, the effect of the absence of adrenergic nerves in the ovary has only been studied in short times periods...
November 21, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29162647/a-unifying-biology-of-sex-steroid-induced-apoptosis-in-prostate-and-breast-cancers
#17
Philipp Y Maximov, Balkees Abderrahman, Ramona F Curpan, Yousef A Hawsawi, Ping Fan, V Craig Jordan
Prostate and breast cancer are the two cancers with the highest incidence in men and women, respectively. Here we focus on the known biology of acquired resistance to antihormone therapy of prostate and breast cancer and compare laboratory and clinical similarities in the evolution of the disease. Laboratory studies and clinical observations in prostate and breast cancer demonstrate that cell selection pathways occur during acquired resistance to antihormonal therapy. Following sex steroid deprivation, both prostate and breast cancer models show an initial increased acquired sensitivity to the growth potential of sex steroids...
November 21, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29162621/needle-use-declarations-at-the-olympic-games-rio-2016
#18
Molly Allen, Mark Campbell Stuart, Hannah Gribble, Richard Budgett, Andrew Pipe
AIM: We report on the results of the 'IOC Needle Policy' applied during the course of the Games of the XXXI Summer Olympiad in Rio de Janeiro, Brazil. The policy was intended to empower physicians to ensure appropriate clinical use of needles within team medical environments, enhance the safety of those responsible for housekeeping services and others in the Olympic environment, and permit documentation of such procedures as an adjunct to the doping control programme. Any needle use required the submission of an 'Injection Declaration Form' to IOC medical officials...
November 21, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29162577/cohort-profile-the-mayo-clinic-cohort-study-of-oophorectomy-and-aging-2-moa-2-in-olmsted-county-minnesota-usa
#19
Walter A Rocca, Liliana Gazzuola Rocca, Carin Y Smith, Brandon R Grossardt, Stephanie S Faubion, Lynne T Shuster, Elizabeth A Stewart, Michelle M Mielke, Kejal Kantarci, Virginia M Miller
PURPOSE: This cohort study was established to investigate the effects of unilateral and bilateral oophorectomy on the ageing processes in women. PARTICIPANTS: We used the records-linkage system of the Rochester Epidemiology Project (REP, http://www.rochesterproject.org) to identify 570 women who underwent unilateral oophorectomy and 1653 women who underwent bilateral oophorectomy in Olmsted County, Minnesota from 1988 through 2007 (20 years). Each woman was matched by age (±1 year) to a population-based referent woman who had not undergone any oophorectomy (570 referent women) or bilateral oophorectomy (1653 referent women)...
November 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/29162485/expression-and-regulation-of-cyp17a1-and-3%C3%AE-hydroxysteroid-dehydrogenase-in-cells-of-the-nervous-system-potential-effects-of-vitamin-d-on-brain-steroidogenesis
#20
Ida Emanuelsson, Mokhtar Almokhtar, Kjell Wikvall, Alfhild Grönbladh, Erik Nylander, Anne-Lie Svensson, Åsa Fex Svenningsen, Maria Norlin
Steroids are reported to have diverse functions in the nervous system. Enzymatic production of steroid hormones has been reported in different cell types, including astrocytes and neurons. However, the information on some of the steroidogenic enzymes involved is insufficient in many respects. Contradictory results have been reported concerning the relative importance of different cell types in the nervous system for expression of CYP17A1 and 3β-hydroxysteroid dehydrogenase (3β-HSD). 3β-HSD is important in all basic steroidogenic pathways and CYP17A1 is required to form sex hormones...
November 18, 2017: Neurochemistry International
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