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https://www.readbyqxmd.com/read/29328976/pattern-of-programmed-cell-death-ligand-1-expression-and-cd8-positive-t-cell-infiltration-before-and-after-chemoradiotherapy-in-rectal-cancer
#1
Atsushi Ogura, Takashi Akiyoshi, Noriko Yamamoto, Hiroshi Kawachi, Yuichi Ishikawa, Seiichi Mori, Koji Oba, Masato Nagino, Yosuke Fukunaga, Masashi Ueno
BACKGROUND: The synergistic effect of combining immune checkpoint inhibitors with radiotherapy was reported recently, but there are few studies on programmed cell death-ligand 1 (PD-L1) expression in rectal cancer treated by preoperative chemoradiotherapy (CRT). The aim of the present study was to investigate the PD-L1 expression status before and after CRT and its association with clinicopathological characteristics and recurrence in rectal cancer. METHODS: Immunostainings of PD-L1 and CD8 were performed in 287 patients with rectal cancer treated by CRT...
January 9, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29297204/role-of-intravoxel-incoherent-motion-mri-in-early-assessment-of-the-response-of-esophageal-squamous-cell-carcinoma-to-chemoradiotherapy-a-pilot-study
#2
Huanhuan Zheng, Wei Ren, Xia Pan, Qinglei Zhang, Baorui Liu, Song Liu, Jian He, Zhengyang Zhou
BACKGROUND: Since definitive concurrent chemoradiotherapy (CRT) is standard therapy for inoperable esophageal squamous cell carcinoma (ESCC), early evaluation of treatment response is crucial for patients and would be useful in assessing response, especially in patients with severe side effects. PURPOSE: To explore the feasibility of intravoxel incoherent motion (IVIM) MRI in the early assessment of treatment response to CRT. STUDY TYPE: Prospective...
January 3, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29276960/relationship-between-bisphenol-a-exposure-and-attention-deficit-hyperactivity-disorder-a-case-control-study-for-primary-school-children-in-guangzhou-china
#3
Yanru Li, Haibin Zhang, Hongxuan Kuang, Ruifang Fan, Caihui Cha, Guanyong Li, Zhiwei Luo, Qihua Pang
Bisphenol A (BPA) is an endocrine-disrupting chemical. Studies have shown that the exposure to BPA is associated with attention-deficit/hyperactivity disorder (ADHD) during adolescent development. However the direct clinical evidence is limited. To investigate the possible association between environmental BPA exposure and the altered behavior of children, a case-control study was conducted with children aged 6-12 years in Guangzhou, China. Two hundred fifteen children diagnosed with ADHD and 253 healthy children from Guangzhou were recruited as the case and control groups, respectively...
December 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29274800/cardiac-resynchronization-therapy-device-implantation-in-a-patient-with-persistent-left-superior-vena-cava-without-communicating-innominate-vein-should-we-proceed-from-the-same-side-a-dilemma-revisited
#4
Debabrata Bera, Neeta Bachani, Prashant Pawar, Chetan Rathi, Vadivelu Ramalingam, Yash Lokhandwala
Persistent left superior vena cava (PLSVC) is an uncommon congenital anomaly. We report a case of implantation of cardiac resynchronization therapy - pacemaker (CRT-P) device in a 38-year-old lady with idiopathic dilated cardiomyopathy. After left axillary vein puncture, we faced an unexpected entry of left subclavian to PLSVC draining into the coronary sinus (CS). The target posterolateral vein which had been identified before seemed to have an acute angle at its entry into the CS. Hence, at this stage we were in a dilemma, whether to switch to the right side or to continue from the same side...
December 21, 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29241091/the-effectiveness-of-group-otago-exercise-program-on-physical-function-in-nursing-home-residents-older-than-65years-a-randomized-controlled-trial
#5
Mirjana Kocic, Zorica Stojanovic, Dejan Nikolic, Milica Lazovic, Rade Grbic, Lidija Dimitrijevic, Marina Milenkovic
AIM: To examine whether the 6-months group-based Otago exercise program is more effective than usual care on physical function and functional independence in nursing home residents older than 65 years. METHODS: An observer-blind randomized controlled study included 77 independently walking, cognitively unimpaired residents aged 78.4±7.6years, of which 66.2% were female. Physical function was assessed at baseline, after 3 and 6months of the Otago exercise program by three performance tests: Berg Balance Scale (BBS), Timed Up and Go (TUG) and Chair Rising Test (CRT), and functional independence by the motor Functional Independence Measure (mFIM)...
December 10, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29228437/shisha-smoking-impact-on-cognitive-functions-impairments-in-healthy-adults
#6
S A Meo, S Bashir, Z Almubarak, Y Alsubaie, H Almutawa
OBJECTIVE: Shisha smoking is becoming highly prevalent and is a predominant mode of tobacco use particularly amongst the young generation around the globe. This study aims to investigate whether or not shisha smoking impairs the cognitive functioning in adolescents. SUBJECTS AND METHODS: We recruited 65 (32 control subjects and 33 shisha smokers) apparently healthy male volunteers. The first group consisted of 33 volunteer male shisha smoker subjects with mean age 24...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29176837/factors-affecting-foveal-avascular-zone-in-healthy-eyes-an-examination-using-swept-source-optical-coherence-tomography-angiography
#7
Atsushi Fujiwara, Yuki Morizane, Mio Hosokawa, Shuhei Kimura, Yusuke Shiode, Masayuki Hirano, Shinichiro Doi, Shinji Toshima, Kosuke Takahashi, Mika Hosogi, Fumio Shiraga
OBJECTIVE: To examine factors affecting foveal avascular zone (FAZ) area in healthy eyes using swept-source optical coherence tomography angiography (OCTA). METHODS: This prospective, cross-sectional study included 144 eyes of 144 individuals (77 women, 67 men) with a best corrected visual acuity of at least 20/20 and no history of ocular disorders. The area of the superficial FAZ was assessed using OCTA. Age, gender, central retinal thickness (CRT), retinal vascular density, refractive error, and axial length were examined to determine associations with FAZ area...
2017: PloS One
https://www.readbyqxmd.com/read/29171319/cost-effectiveness-of-tyrx%C3%A2-absorbable-antibacterial-envelope-for-prevention-of-cardiovascular-implantable-electronic-device-infection
#8
Gemma Kay, Elizabeth L Eby, Benedict Brown, Julie Lyon, Simon Eggington, Gayathri Kumar, Elisabeth Fenwick, M Rizwan Sohail, David Jay Wright
AIMS: Infection is a major complication of cardiovascular implantable electronic device (CIED) therapy that usually requires device extraction and is associated with increased morbidity and mortality. The TYRX Antibacterial Envelope is a polypropylene mesh that stabilises the CIED and elutes minocycline and rifampin to reduce the risk of post-operative infection. METHODS: A decision tree was developed to assess the cost-effectiveness of TYRX versus standard of care (SOC) following implantation of four CIED device types...
November 24, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/29165286/chemoradiation-induced-alteration-of-programmed-death-ligand-1-and-cd8-tumor-infiltrating-lymphocytes-identified-patients-with-poor-prognosis-in-rectal-cancer-a%C3%A2-matched-comparison-analysis
#9
Yu Jin Lim, Jaemoon Koh, Sehui Kim, Sang-Rok Jeon, Eui Kyu Chie, Kyubo Kim, Gyeong Hoon Kang, Sae-Won Han, Tae-You Kim, Seung-Yong Jeong, Kyu Joo Park, Hong-Gyun Wu
PURPOSE: To evaluate chemoradiotherapy (CRT)-induced changes in the expression levels of programmed death-ligand 1 (PD-L1) and CD8+ tumor-infiltrating lymphocytes (TILs) and prognostic associations in rectal cancer. METHODS AND MATERIALS: We performed a paired analysis using pre-CRT biopsies and the corresponding post-CRT resected tissues of 123 rectal cancer patients undergoing preoperative CRT followed by surgery between 2005 and 2012. Immunohistochemistry of PD-L1 and CD8 was analyzed for the specimens...
December 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29161424/clinical-impact-of-implantable-cardioverter-defibrillator-in-primary-prevention-of-total-mortality-in-non-ischaemic-cardiomyopathy-results-from-a-meta-analysis-of-prospective-randomized-clinical-trials
#10
Jorge Romero, Juan Carlos Díaz, Michael Grushko, Renato Quispe, David Briceno, Ricardo Avendano, Anjani Golive, Ileana Pina, Andrea Natale, Mario J Garcia, Ulrich P Jorde, Luigi Di Biase
Aim: Primary prophylactic implantable cardioverter defibrillators (ICDs) have demonstrated a clear all-cause mortality benefit in patients with ischaemic cardiomyopathy, with less compelling evidence supporting its use in patients with non-ischaemic cardiomyopathy (NICM). We performed a meta-analysis of randomized controlled trials (RCTs) evaluating the role of ICD for reduction in total mortality in NICM patients. Methods and results: An electronic search on PubMed, the Cochrane Library, and EMBASE databases was performed to identify the RCTs evaluating the role of prophylactic ICD placement in NICM patients...
November 17, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29147004/dose-de-escalation-to-the-normal-larynx-using-conformal-radiotherapy-reduces-toxicity-while-maintaining-oncologic-outcome-for-t1-t2-glottic-cancer
#11
Jun Won Kim, Hyung Kwon Byeon, Hong-Shik Choi, Ik Jae Lee
We evaluated the efficacy of dose de-escalation to the normal larynx using conformal radiotherapy (CRT) for T1/T2 glottic cancer. For conventional RT (2DRT, n = 38), the laryngeal box received a median equivalent dose in 2 Gy fractions (EQD2) of 66 Gy. For CRT (n = 42; 3D-CRT, 20; intensity-modulated RT, 22), clinical target volume (CTV)1 (gross tumor with a 3-mm margin) and CTV2 (laryngeal box) received median EQD2s of 66.6 Gy and 52.2 Gy, respectively. With a 71-month median follow-up, five-year local control and overall survival rates for 2DRT vs...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138051/sarcopenia-in-peripheral-arterial-disease-prevalence-and-impact-on-functional-status
#12
Odessa Addison, Steven J Prior, Rishi Kundi, Monica C Serra, Leslie I Katzel, Andrew W Gardner, Alice S Ryan
OBJECTIVES: To determine the prevalence of sarcopenia in older men with peripheral arterial disease (PAD) and to compare to a subset of the group to age, race, sex, and body mass index (BMI)-matched non-PAD control counterparts. We also sought to compare the functional status of those with PAD with and without sarcopenia. DESIGN: Cohort study. SETTING: A Veterans Affairs medical center. PARTICIPANTS: Sedentary, community dwelling men age 50+ years with a confirmed diagnosis of PAD (N=108; 44% black; BMI 27...
November 11, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29103057/a-dosimetric-comparison-of-double-arc-volumetric-arc-therapy-step-shoot-intensity-modulated-radiotherapy-and-3d-crt-for-left-sided-breast-cancer-radiotherapy-after-breast-conserving-surgery
#13
Jun-Cong Mo, Jin Huang, Wen-Dong Gu, Min Gao, Zhong-Hua Ning, Jin-Ming Mu, Qi-Lin Li, Hong-Lei Pei
OBJECTIVE: To compare the dosimetric and efficiency differences for left-sided breast cancer radiotherapy after breast-conserving surgery among three different planning techniques: double-arc volumetric-modulate arc therapy (VMAT), step-shoot intensity-modulated radiotherapy (sIMRT) and three-dimensional conformal radiation therapy (3D-CRT). MATERIALS AND METHODS: A total of 17 female patients with left-sided breast cancer who underwent breast-conserving surgery were selected; the prescription doses were 50 Gy in 25 fractions...
October 23, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29077604/twelve-month-efficacy-of-intravitreal-bevacizumab-injection-for-chronic-atypical-or-recurrent-central-serous-chorioretinopathy
#14
Yoo-Ri Chung, Jong Wan Kim, Ji Hun Song, Aram Park, Min Ho Kim
PURPOSE: To evaluate intravitreal bevacizumab (IVB) injection efficacy for the treatment of chronic, atypical, or recurrent central serous chorioretinopathy (CSC). METHODS: Clinical data from 77 eyes of 71 patients with chronic, atypical, or recurrent CSC treated with IVB were retrospectively analyzed. After initial 6-weekly IVB administration until no subretinal fluid remained at the fovea, additional as-needed IVBs were administered, based on optical coherence tomography findings...
October 26, 2017: Retina
https://www.readbyqxmd.com/read/29050686/gender-differences-in-cardiac-resynchronization-therapy-device-choice-and-outcome-in-patients-%C3%A2-75-years-of-age-with-heart-failure
#15
Yanting Wang, Michael S Sharbaugh, Mohammad Bilal Munir, Evan C Adelstein, Norman C Wang, Andrew D Althouse, Samir Saba
Cardiac resynchronization therapy (CRT) is an established therapy for heart failure and can be delivered through a CRT pacemaker (CRT-P) or a CRT defibrillator (CRT-D). CRT-P devices are smaller and less expensive, have better battery longevity, and have been subject to fewer recalls and advisories but cannot deliver high-energy shocks to terminate potentially lethal ventricular arrhythmias. As published guidelines do not distinguish between CRT-P and CRT-D indications, we examined the practice of prescribing these devices in older women and men with heart failure...
September 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29045311/cardiac-resynchronization-therapy-outcomes-in-patients-with-chronic-heart-failure-cardiac-resynchronization-therapy-with-pacemaker-versus-cardiac-resynchronization-therapy-with-defibrillator
#16
Michael Drozd, John Gierula, Judith E Lowry, Maria F Paton, Eleanor Joy, Haqeel A Jamil, Richard M Cubbon, Mark T Kearney, David A Cairns, Klaus K Witte
AIMS: Cardiac resynchronization therapy (CRT) for chronic heart failure with left ventricular systolic dysfunction (LVSD) consistently improves survival against optimal medical therapy alone. Limited data exist comparing the outcomes between CRT with pacemaker (CRT-P) and with defibrillator (CRT-D). We aimed to investigate the long-term prognosis of patients who received CRT-P or CRT-D. METHODS AND RESULTS: Data were prospectively collected from consecutive patients with standard indications for CRT, who were implanted at a single large tertiary centre between 2008 and 2012...
December 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29021972/evaluating-factors-for-prophylactic-feeding-tube-placement-in-gastroesophageal-cancer-patients-undergoing-chemoradiotherapy
#17
Vivek Verma, Pamela K Allen, Steven H Lin
PURPOSE: Though better studied in head/neck cancers, there are currently no studies on timing of feeding tube (FT) placement in patients with gastroesophageal cancer. This study sought to discern characteristics of patients who used versus did not use a prophylactic FT (pFT), and also analyzed factors associated with placement of FTs during chemoradiotherapy (CRT). METHODS/MATERIALS: From 1998 to 2013, 1,329 patients underwent neoadjuvant CRT, of which 323 received an FT...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28993060/routine-bladder-cancer-treatment-dictates-divergence-from-trial-derived-regimens-results-of-treatment-at-44-radiotherapy-centers
#18
Anesa Ahamad, Alvaro Martinez, Sharon Salenius, Rudi Ross, Jason Efstathiou, Eduardo Fernandez
PURPOSE: To assess characteristics and outcome of patients treated with radiotherapy for muscle-invasive bladder cancer at 44 community-based radiotherapy centers and compare these to those on clinical trials. MATERIALS AND METHODS: We reviewed 155 patients who had been treated from 2010 to 2014. Overall survival and progression-free survival were estimated using the Kaplan-Meier method. Results were compared to a pooled analysis of 6 Radiation Therapy Oncology Group (RTOG) protocols...
October 6, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28958674/national-practice-patterns-and-outcomes-for-t4b-urothelial-cancer-of-the-bladder
#19
Waqar Haque, Vivek Verma, E Brian Butler, Bin S Teh
PURPOSE: Management of cT4b bladder cancer is poorly defined; national guidelines recommend chemotherapy (CT) alone or chemoradiation (CRT). Using a large, contemporary dataset, we evaluated national practice patterns as well as associated outcomes, especially with respect to radical cystectomy (RC) and CRT versus CT alone. METHODS: The National Cancer Data Base was queried (2004-2013) for patients diagnosed with cT4bN0-3M0 bladder cancer. Patients were divided into 5 treatment groups: CT alone, CRT, RC (with/without CT/radiotherapy [RT]), other treatment (subtherapeutic RT with/without CT), or no treatment...
September 6, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28862407/an-handbook-for-the-clinical-cardiologist-about-crt-icd-a-pratical-guide-about-how-to-survive-during-an-on-call-shift
#20
Fabiana Lucà, Emilia Biscottini, Laura Cipolletta, Marco Marini, Giorgio Caretta, Alberto Lavorgna, Fabio Vagnarelli, Stefania A DI Fusco, Vincenza Procaccini, Letizia Riva, Gabriele Vianello, Renata DE Maria, Achille Giardina, Michele M Gulizia
INTRODUCTION: Cardiac Resynchronization Therapies (CRTs) have been demonstrated to improve the clinical management and prognosis of selected patients with heart failure. EVIDENCE ACQUISITION: CRT devices include both CRT Pacemakers (CRT-P) and CRT defibrillators (CRT-D), with the latter being used to treat life-threatening ventricular arrhythmias. EVIDENCE SYNTHESIS: A significant advantage of CRTs is the ability to monitor several vital parameters which, thanks to advanced technology, may be remotely assessed...
August 31, 2017: Minerva Cardioangiologica
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