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https://www.readbyqxmd.com/read/28780923/assessment-of-cognitive-function-in-patients-with-metastatic-cancer-are-we-using-the-right-tools
#1
Geana Paula Kurita, Marlene Sandvad, Lena Lundorff, Cibele Andrucioli De Mattos-Pimenta, Jette Højsted, Per Sjøgren
OBJECTIVE: This study aimed at analyzing the validity and reliability of the continuous reaction time (CRT) test, the finger-tapping test (FTT), the Digit Span Test (DST), the Trail Making Test - part B (TMTB), and the Mini-Mental State Examination (MMSE) in patients with metastatic cancer. METHOD: Eighty adult patients and 81 healthy controls were assessed between July of 2010 and November of 2015. The neuropsychological tests were analyzed regarding construct/discriminant/criterion validity and reliability...
August 7, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28748260/clinical-predictors-for-reactive-tube-feeding-in-patients-with-advanced-oropharynx-cancer-receiving-radiotherapy%C3%A2-%C3%A2-%C3%A2-chemotherapy
#2
Belinda Vangelov, Robert I Smee
Enteral feeding is often required for nutrition support in head and neck cancer patients when oral intake is inadequate. When to initiate the insertion of a feeding tube continues to be a debated issue in our institution. We investigated the use of reactive feeding tubes (RFTs) in patients with advanced stage oropharynx cancer (OPC). Data were retrospectively collected on 131 patients who had radiotherapy (RT) ± chemotherapy from 2005 to 2015. Predictors for RFT insertion were investigated. Weight loss during RT was compared between those with RFT versus prophylactic tubes (PFTs) versus no tube, and survival outcomes evaluated...
July 26, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28740910/dosimetric-advantages-of-intensity-modulated-radiation-therapy-in-locally-advanced-lung-cancer
#3
John Boyle, Brad Ackerson, Lin Gu, Chris R Kelsey
PURPOSE: Radiation therapy plays an essential role in the treatment of locally advanced lung cancer, but it inevitably leads to incidental and unnecessary dose to critical organs, including the lung, heart, and esophagus. Numerous radiation dose-volumetric parameters have been associated with increased risk of morbidity and mortality. The purpose of the present study is to quantify differences in normal tissue radiation exposure with intensity modulated radiation therapy (IMRT) compared with 3-dimensional conformal radiation therapy (3D-CRT)...
January 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28719713/lymph-node-positive-cutaneous-nonmelanoma-skin-cancer-a-poor-prognosis-disease-in-need-of-treatment-intensification
#4
Lora S Wang, Elizabeth A Handorf, John A Ridge, Barbara A Burtness, Miriam N Lango, Ranee Mehra, Jeffrey C Liu, Thomas J Galloway
Locoregionally advanced nonmelanoma skin cancer (NMSC) has an aggressive clinical course characterized by high rates of treatment failure and poor survival compared with localized skin cancers. Our goal was to investigate multimodal therapy for lymph-node-positive NMSC. Data from patients with lymph-node-positive NMSC who underwent surgery and adjuvant therapy at a single tertiary center from 2002 to 2012 were retrospectively reviewed. Median follow-up was 1.8 years (range: 0.5 to 8.5). Overall survival (OS) and progression-free survival (PFS) were calculated using the Kaplan-Meier method...
July 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28716973/incremental-benefit-of-cardiac-resynchronisation-therapy-with-versus-without-a-defibrillator
#5
Pieter Martens, Frederik H Verbrugge, Petra Nijst, Matthias Dupont, Dieter Nuyens, Hugo Van Herendael, Maximo Rivero-Ayerza, Wilson H Tang, Wilfried Mullens
OBJECTIVE: To determine the incremental value of implantable cardioverter defibrillators (ICD) in contemporary optimally treated patients with heart failure (HF) undergoing cardiac resynchronisation therapy (CRT). METHODS: Consecutive patients with HF undergoing CRT-pacemaker (CRT-P) or CRT-defibrillator (CRT-D) implantation in a single tertiary care centre between October 2008 and August 2015 were retrospectively evaluated. For patients with a primary prevention indication of the CRT-D, no benefit of the ICD was defined as absence of appropriate therapy (device analysis) or lethal ventricular tachyarrhythmias (mode of death analysis) during follow-up...
July 17, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28701672/the-shortest-qrs-duration-of-an-electrocardiogram-might-be-an-optimal-electrocardiographic-predictor-for-response-to-cardiac-resynchronization-therapy
#6
Jan-Yow Chen, Kuo-Hung Lin, Kuan-Cheng Chang, Che-Yi Chou
QRS duration has been associated with the response to cardiac resynchronization therapy (CRT). However, the methods for defining QRS duration to predict the outcome of CRT have discrepancies in previous reports. The aim of this study was to determine an optimal measurement of QRS duration to predict the response to CRT.Sixty-one patients who received CRT were analyzed. All patients had class III-IV heart failure, left ventricular ejection fraction not more than 35%, and complete left bundle branch block. The shortest, longest, and average QRS durations from the 12 leads of each electrocardiogram (ECG) were measured...
August 3, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28666319/cause-of-death-analysis-in-patients-with-cardiac-resynchronization-therapy-with-or-without-a-defibrillator-a-systematic-review-and-proportional-meta-analysis
#7
Sérgio Barra, Rui Providência, Rudolf Duehmke, Serge Boveda, David Begley, Andrew Grace, Kumar Narayanan, Anthony Tang, Eloi Marijon, Sharad Agarwal
Aims: The additional benefit of a defibrillator in cardiac resynchronization therapy (CRT) patients is a matter of debate. Cause-of-death analysis in a CRT population has been recently proposed as a useful approach to gain insight into this problem. We performed a systematic review and meta-analysis looking at cause of death in studies involving CRT subjects with (CRT-D) or without (CRT-P) a defibrillator. Methods and results: Literature search performed from inception to 31 March 2016 for relevant studies...
June 28, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28662775/improved-survival-with-definitive-chemoradiation-compared-to-definitive-radiation-alone-in-squamous-cell-carcinoma-of-the-vulva-a-review-of-the-national-cancer-database
#8
Yuan James Rao, Re-I Chin, Caressa Hui, David G Mutch, Matthew A Powell, Julie K Schwarz, Perry W Grigsby, Stephanie Markovina
BACKGROUND: It is unclear whether definitive chemoradiation (CRT) results in improved overall survival compared to radiation therapy (RT) alone in patients with vulvar cancer who are not candidates for surgery. We compared these treatment strategies in the National Cancer Database (NCDB). METHODS: We identified 1352 patients with pathologically-confirmed squamous cell carcinoma of the vulva treated with definitive RT (n=353) or definitive CRT (n=999) between 2003 and 2014 in the NCDB...
June 27, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28648948/randomized-phase-ii-study-comparing-prophylactic-cranial-irradiation-alone-to-prophylactic-cranial-irradiation-and-consolidative-extra-cranial-irradiation-for-extensive-disease-small-cell-lung-cancer-ed-sclc-nrg-oncology-rtog-0937
#9
Elizabeth M Gore, Chen Hu, Alexander Y Sun, Daniel F Grimm, Suresh S Ramalingam, Neal E Dunlap, Kristin A Higgins, Maria Werner-Wasik, Aaron M Allen, Puneeth Iyengar, Gregory M M Videtic, Russell K Hales, Ronald C McGarry, James J Urbanic, Anthony T Pu, Candice A Johnstone, Volker W Stieber, Rebecca Paulus, Jeffrey D Bradley
INTRODUCTION: RTOG-0937 is a randomized phase-II trial evaluating 1-year OS with PCI or PCI plus consolidative radiation therapy (cRT) to intra-thoracic disease and extracranial metastases for ED-SCLC. METHODS: Patients with 1-4 extracranial metastases were eligible after CR or PR to chemotherapy. Randomization was to PCI or PCI+cRT to the thorax and metastases. Original stratification included PR vs CR after chemotherapy and 1 vs 2-4 metastases; age < 65 vs > 65 was added after an observed imbalance...
June 22, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28629896/randomized-phase-ii-study-of-preoperative-chemoradiotherapy-panitumumab-followed-by-consolidation-chemotherapy-in-potentially-operable-locally-advanced-stage-iiia-n2-non-small-cell-lung-cancer-nrg-oncology-rtog-0839
#10
Martin J Edelman, Chen Hu, Quynh-Thu Le, Jessica S Donington, Warren D D'Souza, Adam P Dicker, Billy W Loo, Elizabeth M Gore, Gregory M M Videtic, Nathaniel R Evans, Joseph W Leach, Maximilian Diehn, Steven J Feigenberg, Yuhchyau Chen, Rebecca Paulus, Jeffrey D Bradley
INTRODUCTION: Multimodality therapy has curative potential in locally advanced non-small cell lung cancer (LASCLC). Mediastinal nodal sterilization (MNS) after induction chemoradiotherapy (CRT) can serve as an intermediate marker for efficacy. NRG Oncology RTOG 0229 demonstrated the feasibility and efficacy of combining full dose radiation (61.2Gy) with chemotherapy followed by resection and chemotherapy. Based upon that experience and evidence that epidermal growth factor receptor (EGFR) antibodies are radiosensitizing, we explored adding panitumumab to CRT followed by resection and consolidation chemotherapy in LANSCLC with a primary endpoint of MNS...
June 16, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28626201/survival-and-heart-failure-hospitalization-in-patients-with-cardiac-resynchronization-therapy-with-or-without-a-defibrillator-for-primary-prevention-in-japan%C3%A3-analysis-of-the-japan-cardiac-device-treatment-registry-database
#11
Hisashi Yokoshiki, Akihiko Shimizu, Takeshi Mitsuhashi, Hiroshi Furushima, Yukio Sekiguchi, Tetsuyuki Manaka, Nobuhiro Nishii, Takeshi Ueyama, Norishige Morita, Hideo Okamura, Takashi Nitta, Kenzo Hirao, Ken Okumura
BACKGROUND: Randomized control trials comparing the effectiveness of cardiac resynchronization therapy devices, with (CRT-D) or without (CRT-P) a defibrillator, are scarce in heart failure patients with no prior sustained ventricular tachyarrhythmias.Methods and Results:The Japan Cardiac Device Treatment Registry (JCDTR) has data for 2714 CRT-D and 555 CRT-P recipients for primary prevention with an implantation date between January 2011 and August 2015. Of these patients, follow-up data were available for 717...
June 13, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28601912/effects-of-photodynamic-therapy-plus-intravitreal-aflibercept-with-subtenon-triamcinolone-injections-for-aflibercept-resistant-polypoidal-choroidal-vasculopathy
#12
Tsutomu Sakai, Noriko Kato, Masaomi Kubota, Hiroshi Tsuneoka
PURPOSE: To evaluate the outcome of triple therapy of photodynamic therapy combined with injections of intravitreal aflibercept (IVA) and subtenon triamcinolone acetonide for polypoidal choroidal vasculopathy (PCV) resistant to IVA. METHODS: A retrospective chart review at a single institution was conducted to identify patients with PCV resistant to treatment with IVA who were switched to treatment with triple therapy. In total, 13 eyes from 13 patients were included in the study...
August 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28558382/znf750-expression-as-a-novel-candidate-biomarker-of-chemoradiosensitivity-in-esophageal-squamous-cell-carcinoma
#13
Ryota Otsuka, Yasunori Akutsu, Haruhito Sakata, Naoyuki Hanari, Kentaro Murakami, Masayuki Kano, Masahiko Takahashi, Yasunori Matsumoto, Nobufumi Sekino, Masaya Yokoyama, Keiko Iida, Hisahiro Matsubara
OBJECTIVE: ZNF750, an epidermal differentiation regulator, has been suggested to act as a tumor suppressor of esophageal squamous cell carcinoma (ESCC). Although a correlation between the epidermal differentiation gene and resistance to chemoradiotherapy (CRT) has been posited, no data regarding the ZNF750 status in ESCC have been reported. The aim of the present study was to evaluate the relationship between ZNF750 expression and response to CRT in ESCC. METHODS: Eighty-seven patients who had been pathologically diagnosed with ESCC were evaluated in the present study...
May 31, 2017: Oncology
https://www.readbyqxmd.com/read/28451588/lead-extraction-of-cardiac-rhythm-devices-a-report-of-a-single-center-experience
#14
Ana Isabel Azevedo, João Primo, Helena Gonçalves, Marco Oliveira, Luís Adão, Elisabeth Santos, José Ribeiro, Marlene Fonseca, Adelaide V Dias, Luís Vouga, Vasco Gama Ribeiro
INTRODUCTION AND OBJECTIVES: The rate of implanted cardiac electronic devices is increasing as is the need to manage long-term complications. Lead removal is becoming an effective approach to treat such complications. We present our experience in lead removal using different approaches, analyzing the predictors of the use of mechanical extractors/surgical removal. METHODS: Retrospective analysis of lead extractions in a series of 76 consecutive patients (mean age 70...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28388657/clinical-decision-tool-for-crt-p-vs-crt-d-implantation-findings-from-prose-icd
#15
Victor Nauffal, Yiyi Zhang, Tanyanan Tanawuttiwat, Elena Blasco-Colmenares, John Rickard, Joseph E Marine, Barbara Butcher, Sanaz Norgard, Timm-Michael Dickfeld, Kenneth A Ellenbogen, Eliseo Guallar, Gordon F Tomaselli, Alan Cheng
BACKGROUND: Cardiac resynchronization therapy (CRT) devices reduce mortality through pacing-induced cardiac resynchronization and implantable cardioverter defibrillator (ICD) therapy for ventricular arrhythmias (VAs). Whether certain factors can predict if patients will benefit more from implantation of CRT pacemakers (CRT-P) or CRT defibrillators (CRT-D) remains unclear. METHODS AND RESULTS: We followed 305 primary prevention CRT-D recipients for the two primary outcomes of HF hospitalization and ICD therapy for VAs...
2017: PloS One
https://www.readbyqxmd.com/read/28359512/should-nonischemic-crt-candidates-receive-crt-p-or-crt-d
#16
EDITORIAL
Wayne C Levy
No abstract text is available yet for this article.
April 4, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28329322/utilization-and-in-hospital-complications-of-cardiac-resynchronization-therapy-trends-in-the-united-states-from-2003-to-2013
#17
Seyed Mohammadreza Hosseini, Kasra Moazzami, Guy Rozen, Jeena Vaid, Ahmed Saleh, E Kevin Heist, Mark Vangel, Jeremy N Ruskin
Aims: Cardiac resynchronization therapy (CRT) device implantation has been shown to reduce morbidity and mortality in selected patients with heart failure. We sought to investigate the utilization and in-hospital complications of cardiac resynchronization therapy defibrillator (CRT-D) and pacemaker (CRT-P) implantations in the United States from 2003 to 2013. Methods and results: Patients receiving CRT-D or CRT-P were identified in the National Inpatient Sample database (NIS), using the International Classification of Diseases-Ninth Revision-Clinical Modification procedure codes...
March 13, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28254126/economic-value-and-cost-effectiveness-of%C3%A2-cardiac-resynchronization-therapy-among-patients-with-mild-heart-failure-projections-from-the-reverse-long-term-follow-up
#18
Michael R Gold, Amie Padhiar, Stuart Mealing, Manpreet K Sidhu, Stelios I Tsintzos, William T Abraham
OBJECTIVES: This study investigated the cost effectiveness of early cardiac resynchronization therapy (CRT) implantation among patients with mild heart failure (HF). The differential cost effectiveness between CRT using a defibrillator (CRT-Ds) and CRT using a pacemaker (CRT-P) was also assessed. BACKGROUND: Cardiac resynchronization has been shown to be cost effective in New York Heart Association (NYHA) functional classes III/IV but is less studied in class II HF...
March 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28243333/chemoradiotherapy-versus-radiotherapy-alone-in-stage-ii-nasopharyngeal-carcinoma-a-systemic-review-and-meta-analysis-of-2138-patients
#19
Cheng Xu, Li-He Zhang, Yu-Pei Chen, Xu Liu, Guan-Qun Zhou, Ai-Hua Lin, Ying Sun, Jun Ma
Background: To explore the value of chemoradiotherapy (CRT) in stage II nasopharyngeal carcinoma (NPC) compared to radiotherapy (RT) alone which includes two-dimensional radiotherapy (2D-RT) and intensity-modulated radiotherapy (IMRT). Methods: All topic-related comparative articles were identified by a comprehensive search of public databases (MEDLINE, EMBASE, Cochrane Library and CBMdisc). The primary outcomes were overall survival (OS), loco-regional relapse-free survival (LRRFS) and distant metastasis-free survival (DMFS)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28204917/-ecg-score-to-predict-icd-therapies-in-patients-with-nonischemic-cardiomyopathy-and-primary-prophylactic-crt-d
#20
Martin Grett, Martin Christ, Jan-Peter Röing Gen Nölke, Hans-Joachim Trappe
BACKGROUND AND PROBLEM: Recently published results of the DANISH study raise concerns, if primary prophylactic ICD implantations in patients with nonischemic cardiomyopathy (NICM) and severe reduced left ventricular ejection fraction (LVEF) should be performed without further risk stratification. There was no significant difference in the overall mortality of patients with or without ICD and CRT defibrillator (CRT-D) or CRT pacemaker (CRT-P), respectively. Clinical risk scores to identify patients with ischemic cardiomyopathy (ICM) who benefit most from an ICD have been recommended...
February 15, 2017: Herzschrittmachertherapie & Elektrophysiologie
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