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https://www.readbyqxmd.com/read/28043710/complication-and-surgical-site-infection-for-salvage-surgery-in-head-and-neck-cancer-after-chemoradiotherapy-and-bioradiotherapy
#1
Hidenori Suzuki, Nobuhiro Hanai, Daisuke Nishikawa, Yujiro Fukuda, Yasuhisa Hasegawa
OBJECTIVE: We aimed to investigate the complications, surgical site infection (SSI), and survival in salvage surgery without free-flap reconstruction for patients with head and neck squamous cell carcinoma who were treated by platinum-based chemoradiotherapy (Plat-CRT) or cetuximab-based bioradiotherapy (Cet-BRT). METHODS: Thirty-three patients treated by Plat-CRT and six treated by Cet-BRT had salvage surgery. We categorized postoperative complications according to the Clavien-Dindo classification and SSI according to the wound grading scale...
December 30, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28031276/patients-upgraded-to-cardiac-resynchronization-therapy-due-to-pacing-induced-cardiomyopathy-are-at-low-risk-of-life-threatening-ventricular-arrhythmias-a-long-term-cause-of-death-analysis
#2
Sergio Barra, Rudolf Duehmke, Rui Providencia, Eloi Marijon, Serge Boveda, Munmohan Virdee, Patrick Heck, Simon Fynn, David Begley, Andrew Grace, Sharad Agarwal
AIMS: Upgrade to cardiac resynchronization therapy (CRT) should be offered to patients who have developed pacing-induced cardiomyopathy with conventional right ventricular pacing. The extent to which these patients would also benefit from defibrillator back-up at the time of CRT upgrade is, however, unknown. METHODS AND RESULTS: Retrospective observational cohort study of 199 patients with pacing-induced cardiomyopathy and no history of sustained ventricular arrhythmia, including 104 upgraded to CRT-Pacemaker (CRT-P) and 95 upgraded to CRT-Defibrillator (CRT-D)...
December 28, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28011795/cardiac-resynchronization-therapy-crt-device-replacement-considerations-upgrade-or-downgrade-a-complex-decision-in-the-current-clinical-setting
#3
REVIEW
Eleni S Nakou, Emmanuel N Simantirakis, Eleftherios M Kallergis, Konstantinos S Nakos, Panos E Vardas
There are limited data about the management of patients presenting for elective generator replacements in the setting of previously implanted cardiac resynchronization therapy (CRT) devices that are nearing end-of-life. The individual patient's clinical status and concomitant morbidities may evolve so that considerations may include not only replacement of the pulse generator, but also potentially changing the type of device [e.g. downgrading CRT-defibrillator (CRT-D) to CRT-pacemaker (CRT-P) or ICD or upgrading of CRT-P to CRT-D]...
December 23, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28011494/mmri-at-3-0-t-as-an-evaluation-tool-of-therapeutic-response-to-neoadjuvant-crt-in-patients-with-advanced-stage-rectal-cancer
#4
Ulrike I Attenberger, Melissa M Ong, Nils Rathmann, Fabian Doyon, Peter Kienle, Ralf-Dieter Hofheinz, Lothar R Pilz, Dietmar J Dinter, Stefan O Schoenberg, Daniel Hausmann
AIM: To assess whether multiparametric MRI (mMRI) can serve as a tool for evaluating response to chemoradiation therapy (CRT) in advanced-stage rectal cancer. PATIENTS AND METHODS: Twenty-one patients underwent a mMRI protocol at 3T before and after CRT. Two experienced radiologists evaluated the MRI measurements and inter-reader correlation was assessed. Changes in functional parameters in relation to regression, as well as pT stage were analyzed. The perfusion parameters plasma flow (PF) and mean transit time (MTT) were calculated offline using the established UMM Perfusion tool...
January 2017: Anticancer Research
https://www.readbyqxmd.com/read/27925329/fragmented-qrs-is-a-novel-risk-factor-for-ventricular-arrhythmic-events-after-receiving-cardiac-resynchronization-therapy-in-non-ischemic-cardiomyopathy
#5
Miyako Igarashi, Hiroshi Tada, Hiro Yamasaki, Kenji Kuroki, Tomoko Ishizu, Yoshihiro Seo, Takeshi Machino, Nobuyuki Murakoshi, Yukio Sekiguchi, Yuichi Noguchi, Akihiko Nogami, Kazutaka Aonuma
INTRODUCTION: A fragmented QRS (fQRS) is reported to be associated with a poor prognosis or sudden cardiac death (SCD) in patients with Brugada syndrome or ischemic heart disease. However, no studies have clarified the impact of the presence of an fQRS on SCD or ventricular arrhythmic events in patients receiving cardiac resynchronization therapy (CRT). This study aimed to clarify this point in patients with non-ischemic cardiomyopathy. METHODS AND RESULTS: This study included 137 heart failure patients with non-ischemic cardiomyopathy who received CRT (NYHA functional class: II/III/IV = 25/84/28)...
December 7, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27920834/trends-and-determinant-factors-in-the-use-of-cardiac-resynchronization-therapy-devices-in-japan-analysis-of-the-japan-cardiac-device-treatment-registry-database
#6
Hisashi Yokoshiki, Akihiko Shimizu, Takeshi Mitsuhashi, Hiroshi Furushima, Yukio Sekiguchi, Tetsuyuki Manaka, Nobuhiro Nishii, Takeshi Ueyama, Norishige Morita, Takashi Nitta, Ken Okumura
BACKGROUND: The choice of cardiac resynchronization therapy device, with (CRT-D) or without (CRT-P) a defibrillator, in patients with heart failure largely depends on the physician׳s discretion, because it has not been established which subjects benefit most from a defibrillator. METHODS: We examined the annual trend of CRT device implantations between 2006 and 2014, and evaluated the factors related to the device selection (CRT-D or CRT-P) for primary prevention of sudden cardiac death in patients with heart failure by analyzing the Japan Cardiac Device Treatment Registry (JCDTR) database from January 2011 and August 2015 (CRT-D, n=2714; CRT-P, n=555)...
December 2016: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27903393/-a-multi-center-study-on-the-long-term-mortality-and-related-risk-factors-in-patients-with-chronic-heart-failure-receiving-resynchronization-therapy
#7
S Y Qi, D M Wang, H B Yu, C Ding, F L Tian, L S Ru, J Li, B Zhang, Y L Han
Objective: To analyze long-term mortality and patients characteristics of cardiac resynchronization therapy (CRT) for patients with chronic heart failure. Methods: In-patients with chronic heart failure who received CRT in the three medical centers(Bethune International Peace Hospital, General Hospital of Shenyang Military Command of Chinese People's Liberation Army, and 251 Hospital of People's Liberation Army)from March 2001 to June 2013 were included.Mortality and related causes, echocardiographic parameters were analyzed...
November 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27903247/preoperative-conventional-chemoradiotherapy-versus-short-course-radiotherapy-with-delayed-surgery-for-rectal-cancer-results-of-a-randomized-controlled-trial
#8
Tadas Latkauskas, Henrikas Pauzas, Laura Kairevice, Aleksandras Petrauskas, Zilvinas Saladzinskas, Rasa Janciauskiene, Jurate Gudaityte, Paulius Lizdenis, Saulius Svagzdys, Algimantas Tamelis, Dainius Pavalkis
BACKGROUND: There still is no evidence which neoadjuvant therapy regimen for stage II-III rectal cancer is superior. The aim of this study was to compare results achieved after long-course chemoradiotherapy (CRT) with short-term radiotherapy (RT) followed by delayed surgery. METHODS: A randomized trial was carried out between 2007-2013. One hundred fifty patients diagnosed with stage II-III rectal cancer were randomized into one of two neoadjuvant treatment arms: conventional chemoradiotherapy (CRT) and short-term radiotherapy (RT) followed by surgery after 6-8 weeks...
December 1, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27893199/prognostic-factors-in-stage-iii-non-small-cell-lung-cancer-patients
#9
Semiha Elmaci Urvay, Birsen Yucel, Eda Erdis, Nedim Turan
Aim: The objective of this study is to investigate prognostic factors affecting survival of patients undergoing concurrent or sequential chemoradiotherapy (CRT) for stage III non-small-cell lung cancer (NSCL). Methods and materials: We retrospectively reviewed the clinical records of 148 patients with advanced, inoperable stage III NSCLC, who were treated between 2007 and 2015. Results: The median survival was found to be 19 months and 3-year overall survival was 27%. Age (<65 vs ≥65 years, p=0.026), stage (IIIA vs IIIB, p=0...
1, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27886920/why-we-have-to-use-cardiac-resynchronization-therapy-pacemaker-more
#10
REVIEW
Jean-Claude Daubert, Raphaël Martins, Christophe Leclercq
Both cardiac resynchronization therapy with a pacemaker (CRT-P) and with a biventricular implantable cardioverter-defibrillator (CRT-D) are electrical treatment modalities validated for the management of chronic heart failure. There is no strong scientific evidence that a CRT-D must be offered to all candidates. Common sense should limit the prescription of these costly and complicated devices. The choice of CRT-P is currently acceptable. A direction to explore could be to downgrade from CRT-D to CRT-P at the time of battery depletion in patients with large reverse remodeling and no ventricular tachycardia and ventricular fibrillation detected...
January 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/27777791/intravitreal-conbercept-injection-with-and-without-grid-laser-photocoagulation-in-the-treatment-of-diffuse-diabetic-macular-edema-in-real-life-clinical-practice
#11
Yule Xu, Ao Rong, Yanlong Bi, Wei Xu
Purpose. To evaluate the efficacy of intravitreal conbercept (IVC) plus modified grid laser photocoagulation (MGP) versus IVC alone for treatment of diffuse diabetic macular edema (DDME). Methods. In this retrospective study, 51 DDME patients were treated with either IVC alone (IVC group) or IVC plus MGP (combined group) with 12 months of follow-up. The clinical records of those patients were reviewed. Results. 26 patients (31 eyes) received IVC alone and 25 patients (30 eyes) received combined therapy. At month 12, the mean best-corrected visual acuity (BCVA) letter score improvement was 9...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27756040/predictors-of-response-to-cardiac-resynchronization-therapy-a-systematic-review
#12
John Rickard, Henry Michtalik, Ritu Sharma, Zackary Berger, Emmanuel Iyoha, Ariel R Green, Nowreen Haq, Karen A Robinson
BACKGROUND: Multiple studies have sought to determine variables associated with improved "response" to cardiac resynchronization therapy(CRT). Such variables, however, are often derived from inadequately controlled, single center cohort studies calling external validity into question. We sought to determine predictors of response to CRT-D and CRT-P utilizing the methods of systematic review. METHODS: We searched MEDLINE, Embase®, and the Cochrane Central Register of Controlled Trials (CENTRAL) from January 1, 1995, as this is the date of first article reporting use of CRT through October 20, 2014...
September 25, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27733457/morbidity-and-mortality-with-cardiac-resynchronization-therapy-with-pacing-vs-with-defibrillation-in-octogenarian-patients-in-a-real-world-setting
#13
Avishag Laish-Farkash, Sharon Bruoha, Amos Katz, Ilan Goldenberg, Mahmoud Suleiman, Yoav Michowitz, Nir Shlomo, Michal Einhorn-Cohen, Vladimir Khalameizer
AIMS: Cardiac resynchronization therapy (CRT) with a defibrillator (CRT-D) has downsides of high cost and inappropriate shocks compared to CRT without a defibrillator (CRT-P). Recent data suggest that the survival benefit of implantable cardioverter defibrillator (ICD) therapy is attenuated in the older age group. We hypothesized that, among octogenarians eligible for cardiac resynchronization therapy, CRT-P confers similar morbidity and mortality benefits as CRT-D. METHODS AND RESULTS: We compared morbidity and mortality outcomes between consecutive octogenarian patients eligible for CRT therapy who underwent CRT-P implantation at Barzilai MC (n = 142) vs...
October 12, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27730803/radiation-therapy-for-gastric-mucosa-associated-lymphoid-tissue-lymphoma-dose-volumetric-analysis-and-its-clinical-implications
#14
Hyeon Woo Lim, Tae Hyun Kim, Il Ju Choi, Chan Gyoo Kim, Jong Yeul Lee, Soo Jeong Cho, Hyeon Seok Eom, Sung Ho Moon, Dae Yong Kim
PURPOSE: To assess the clinical outcomes of radiotherapy (RT) using two-dimensional (2D) and three-dimensional conformal RT (3D-CRT) for patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma to evaluate the effectiveness of involved field RT with moderate-dose and to evaluate the benefit of 3D-CRT comparing with 2D-RT. MATERIALS AND METHODS: Between July 2003 and March 2015, 33 patients with stage IE and IIE gastric MALT lymphoma received RT were analyzed...
September 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27645220/epicardial-crt-p-and-s-icd-implantation-in-a-young-patient-with-persistent-left-superior-vena-cava
#15
Julia W Erath, Abdul Sami Sirat, Mate Vamos, Stefan H Hohnloser
Persistent left superior vena cava is known to be a challenging anatomic abnormality for transvenous cardiac device implantation. In the a case of a young man presenting with dilative cardiomyopathy with severely impaired left ventricular ejection fraction (LVEF) and second-degree atrioventricular block (AV block), cardiac resynchronization therapy (CRT) with defibrillator (CRT-D) implantation was indicated. A transvenous approach was attempted, but placement of the right ventricular lead was not successful due to anatomic abnormalities...
December 2016: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/27632214/predictive-factors-for-functional-improvement-following-intravitreal-bevacizumab-injections-after-central-retinal-vein-occlusion
#16
Kai Januschowski, Nicolas Feltgen, Amelie Pielen, Bernhard Spitzer, Matus Rehak, Georg Spital, Spyridon Dimopoulos, Carsten H Meyer, Gesine B Szurman
PURPOSE: Vision loss in central retinal vein occlusion (CRVO) is mostly caused by macular edema (ME) and can be treated with intravitreal bevacizumab injections. The goal of this study was to identify predictive factors for improvement in visual acuity. METHODS: Three hundred and sixteen eyes of six centres having received intravitreal bevacizumab for ME due to CRVO were enrolled in this multicentre, retrospective, interventional case series. The follow-up time was 24 to 48 weeks...
September 8, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27531355/classification-of-diabetic-macular-oedema-using-ultra-widefield-angiography-and-implications-for-response-to-anti-vegf-therapy
#17
Kanmin Xue, Elizabeth Yang, N Victor Chong
AIMS: To characterise differential pathogeneses of diabetic macular oedema (DMO) using ultra-widefield fluorescein angiography (UWFA) and evaluate responses to anti-vascular endothelial growth factor (anti-VEGF) therapy. METHODS: Ninety-nine eyes (73 consecutive patients) with anti-VEGF naïve DMO underwent UWFA and optical coherence tomography, of which 60 with central retinal thickness (CRT) >400 μm received monthly intravitreal ranibizumab injections. Best-corrected visual acuity (BCVA) and CRT were measured at baseline and after three injections...
August 16, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27498203/pretreatment-factors-associated-with-functional-oral-intake-and-feeding-tube-use-at-1-and-6%C3%A2-months-post-radiotherapy-chemotherapy-for-head-and-neck-cancer
#18
Molly K Barnhart, Elizabeth C Ward, Bena Cartmill, Rachelle A Robinson, Virginia A Simms, Sophie J Chandler, Elea T Wurth, Robert I Smee
A proportion of patients with head and neck cancer (HNC) experience significant swallowing difficulty during and post-radiotherapy/chemoradiotherapy (RT/CRT). Identifying patients during the pretreatment period who are anticipated to have compromised oral intake would allow for early and accurate patient education, and prioritisation of their management. Ascertaining a clear set of pretreatment predictors from the literature is challenging due to heterogeneity in study designs and patient cohorts, with minimal prospective data available (especially at 1-month post-treatment)...
August 6, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27485565/use-of-a-novel-pacing-mode-to-achieve-biventricular-pacing-in-a-patient-with-recurrent-atrial-lead-dislodgement-after-crt-d-implantation
#19
Soumen Devidutta, Chennapragada Sridevi, Calambur Narasimhan
Cardiac resynchronization therapy device (CRT-P and CRT-D) implantation has increased tremendously with increasing operator experience, eligible patients and expansion of indications. Refinements in devices and algorithms now aid physicians to improve biventricular pacing and optimize CRT. We report a case in which an interesting device program was used to achieve biventricular pacing after repeated dislodgement of the atrial lead in a patient implanted with CRT-D.
January 2016: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/27475261/pacemaker-use-in-new-zealand-data-from-the-new-zealand-implanted-cardiac-device-registry-anzacs-qi-15
#20
P D Larsen, A J Kerr, M Hood, S A Harding, D Hooks, D Heaven, N A Lever, S Sinclair, D Boddington, E W Tang, J Swampillai, M K Stiles
BACKGROUND: The New Zealand Cardiac Implanted Device Registry (Device) has recently been developed under the auspices of the New Zealand Branch of the Cardiac Society of Australia and New Zealand. This study describes the initial Device registry cohort of patients receiving a new pacemaker, their indications for pacing and their perioperative complications. METHODS: The Device Registry was used to audit patients receiving a first pacemaker between 1(st) January 2014 and 1(st) June 2015...
July 19, 2016: Heart, Lung & Circulation
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